Updated on 2022/10/01

写真a

 
OYAMA Takanori
 
Organization
Okayama University Hospital Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • 博士(医学) ( 2007.9   岡山大学 )

Research Areas

  • Life Science / General surgery and pediatric surgery

Research History

  • Okayama University Hospital   Pediatric surgery   Assistant Professor

    2022.4

      More details

Professional Memberships

▼display all

 

Papers

  • Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression. International journal

    Terutaka Tanimoto, Hiroshi Tazawa, Takeshi Ieda, Hiroshi Nouso, Morimichi Tani, Takanori Oyama, Yasuo Urata, Shunsuke Kagawa, Takuo Noda, Toshiyoshi Fujiwara

    Molecular therapy oncolytics   18   14 - 23   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Neuroblastoma (NB) is a primary malignant tumor of the peripheral sympathetic nervous system. High-risk NB is characterized by MYCN amplification and human telomerase reverse transcriptase (hTERT) rearrangement, contributing to hTERT activation and a poor outcome. For targeting hTERT-activated tumors, we developed two oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in which the hTERT promoter drives expression of the viral E1 gene for tumor-specific virus replication. In this study, we demonstrate the therapeutic potential of the hTERT-driven oncolytic adenoviruses OBP-301 and OBP-702 using four human MYCN-amplified NB cell lines (IMR-32, CHP-134, NB-1, LA-N-5) exhibiting high hTERT expression. OBP-301 and OBP-702 exhibited a strong antitumor effect in association with autophagy in NB cells. Virus-mediated activation of E2F1 protein suppressed MYCN expression. OBP-301 and OBP-702 significantly suppressed the growth of subcutaneous CHP-134 tumors. Thus, these hTERT-driven oncolytic adenoviruses are promising antitumor agents for eliminating MYCN-amplified NB cells via E2F1-mediated suppression of MYCN protein.

    DOI: 10.1016/j.omto.2020.05.015

    PubMed

    researchmap

  • Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature. International journal

    Takanori Oyama, Takuo Noda, Kana Washio, Akira Shimada

    Medicine   99 ( 38 )   e22297   2020.9

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    RATIONALE: Growing teratoma syndrome is defined as an increase in tumor size during or after systemic chemotherapy for germ cell tumors. These cases involve normal tumor maker levels and histological features of only mature teratoma. We report a rare case of an ovarian immature teratoma in a Japanese child that was diagnosed as growing teratoma syndrome. PATIENT CONCERNS: A 12-year-old girl presented a painful abdominal mass. She underwent left salpingo-oophorectomy for grade 1 immature teratoma in the left ovary. She did not undergo additional chemotherapy or radiotherapy. Four months later, she presented with grade 3 immature teratoma disseminated into the abdomen and pelvis. Chemotherapy resulted in the tumor maker levels returning to their normal ranges, although the tumors had grown slightly. DIAGNOSIS: The specimens resected by laparotomy after the chemotherapy consisted of mature tissue predominantly, although primitive neuroepithelium was observed in a small part of the specimen. The pathological diagnosis was grade 1 immature teratoma, notwithstanding the clinical diagnosis was growing teratoma syndrome based on the clinical features and pathogenesis. INTERVENTIONS: Laparotomy was performed at 7 months after the first operation, with resection of various tumors as well as the rectum, sigmoid colon, residual left fallopian duct, and a small part of the ileum and omentum. Some small tumors at the parietal peritoneum were ablated, although many tiny tumors around the uterus were left untreated. OUTCOMES: The patient has been free from recurrence for 5 years. LESSONS: Growing teratoma syndrome can develop in children, and their tumor size is comparable to that in adolescents and adults. Furthermore, development of growing teratoma syndrome from a primary germ cell tumor is presumably faster in children than in adolescents and adults. Complete resection of all growing teratoma tissue is recommended, although fertility-sparing surgery should be considered when possible.

    DOI: 10.1097/MD.0000000000022297

    PubMed

    researchmap

  • Standard protocol devised by the Japanese Pediatric Impedance Working Group for combined multichannel intraluminal impedance-pH measurements in children.

    Suguru Fukahori, Hisayoshi Kawahara, Takanori Oyama, Takeshi Saito, Ryuichi Shimono, Aya Tanaka, Takuo Noda, Reiko Hatori, Junko Fujino, Minoru Yagi

    Surgery today   50 ( 7 )   664 - 671   2020.7

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    Multichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the standard protocol of MII-pH. The standard protocol included standardization of the indication, methodology, and interpretation of MII-pH in Japanese children. The criteria for abnormal GER by MII-pH were defined using the Reflux Index and number of total reflux episodes independently in children aged < 1 year and those aged ≥ 1 year. Moreover, a significant relationship between GER and symptoms was identified using the symptom index and symptom association probability approach. We conclude that the current version of the protocol for MII-pH is tentative because it is not based on data from Japanese children. Further studies are needed to render this protocol clinically beneficial and expand its use in Japan.

    DOI: 10.1007/s00595-019-01833-6

    PubMed

    researchmap

  • Correction to: Standard protocol devised by the Japanese Pediatric Impedance Working Group for combined multichannel intraluminal impedance-pH measurements in children.

    Suguru Fukahori, Hisayoshi Kawahara, Takanori Oyama, Takeshi Saito, Ryuichi Shimono, Aya Tanaka, Takuo Noda, Reiko Hatori, Junko Fujino, Minoru Yagi

    Surgery today   50 ( 7 )   672 - 672   2020.7

     More details

    Language:English  

    The authors would like to add the following sentence in Acknowledgements in the original publication of this paper.

    DOI: 10.1007/s00595-019-01892-9

    PubMed

    researchmap

  • 小児脳室腹腔シャント術における腹腔鏡の手技 自験例の検討

    尾山 貴徳, 野田 卓男, 谷本 光隆, 亀田 雅博, 小野 成紀

    日本内視鏡外科学会雑誌   25 ( 4 )   332 - 338   2020.7

     More details

    Language:Japanese   Publisher:(一社)日本内視鏡外科学会  

    <文献概要>腹腔鏡補助下脳室腹腔シャント術は成人では広まりつつあるが,小児の報告は未だ少ない.当科で施行した5例の手術手技の要点を報告する.まず,体格の小さい小児の周囲に多数の人員・機材を配置するため,互いに干渉しないよう注意が必要であった.初回手術では2ポート,再建時など腹腔内の癒着がある場合は単孔式3ポートとした.新生児ではスコープ・鉗子ともに臍部ではなく側腹部から挿入した.皮下を通したパッサーは,直接腹腔内へ挿入した.シャントチューブは屈曲しないように鉗子で誘導し,シャントの開通も腹腔鏡で確認した.手術合併症は認めなかった.手技の定型化により,成人と同様な有用性が示されることが期待される.

    researchmap

  • 多脾症候群に合併した胃軸捻転症に対して、腹腔鏡下胃固定術および脾臓摘出術を施行した1例

    納所 洋, 野田 卓男, 谷 守通, 尾山 貴徳, 谷本 光隆, 宮田 将徳

    日本小児外科学会雑誌   55 ( 6 )   1076 - 1080   2019.10

     More details

    Language:Japanese   Publisher:(一社)日本小児外科学会  

    症例は13歳女児。先天性心疾患および多脾症候群のため、小児科で加療されていた。12歳時、検査入院中に、血性嘔吐が出現し当科を受診した。胃軸捻転症および遊走脾と診断した。経鼻胃管による減圧で症状が消失し経過観察としたが、その後短期間で複数回の捻転が生じたため、腹腔鏡下胃固定術および脾臓摘出術を行った。術中観察では逆位の胃および複数の脾臓を認めた。後腹膜に固定された一部の脾臓を温存し、残る遊走脾を切除後、胃と腹壁を固定した。また、無回転型腸回転異常症を認めたため、予防的虫垂切除を行った。術後経過は良好で症状再発なく3年が経過している。多脾症候群には多様な心血管奇形や腹腔内臓器奇形を合併することが多い。胆道閉鎖症や腸回転異常症の合併が報告されているが、胃軸捻転症は極めて稀である。個々の症例において臨床像が異なるため、治療方針については十分な検討を要する。(著者抄録)

    researchmap

    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J01113&link_issn=&doc_id=20191105140035&doc_link_id=%2Fes5shoge%2F2019%2F005506%2F008%2F1076-1080%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fes5shoge%2F2019%2F005506%2F008%2F1076-1080%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

▼display all

MISC

▼display all

Presentations

▼display all

Research Projects

  • 小児外科学

    1999

    その他の研究制度 

      More details

    Grant type:Competitive

    researchmap

  • Pediatric Surgery

    1999

    The Other Research Programs 

      More details

    Grant type:Competitive

    researchmap