研究者詳細 - 神農　泰生

論文 - 神農　泰生

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臼歯直接修復用コンポジットレジンの物性に関する検討

神農泰生, 糸田俊之, 田代陽子, 吉光景子, 吉山昌宏

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 102 - 102 2006年10月

ワンボトルワンステップ接着システムの採取後の放置時間が歯質接着性に及ぼす影響

山田敦子, 高畑安光, 吉光景子, 田中久美子, 野本正盛, 田代陽子, 大前正範, 土居潤一, 神農泰生, 糸田俊之, 吉山昌宏

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 72 - 72 2006年10月

Dentin Regeneration by Direct Pulp Capping Using a Bioabsorbable Material

ITOTA Toshiyuki, TASHIRO Yoko, TAKAGI Ryo, YAMAJI Kozo, SHINNO Yasuo, IZAWA Shunji, OMAE Masanori, YOSHIYAMA Masahiro

Journal of oral tissue engineering 4 ( 1 ) 17 - 24 2006年9月

記述言語：英語出版者・発行元：日本再生歯科医学会

The aim of this study was to investigate the effect of bioabsorbable material on the direct pulp capping to know whether this material has a function in dentin regeneration by bioabsorption. Class V cavities with the exposed pulp area were prepared on the buccal surface of first molars in young beagle dogs. All cavities were conditioned with a self-etching primer (Clearfil SE Primer). In the cavities of right side (experimental group), the exposed pulp was covered with a bioabsorbable sheet (Kurabio AG), and then the cavities were coated with an adhesive agent (Clearfil SE Bond) and resorted with a resin composite. The left side cavities (control group) were applied the adhesive agent without the bioabsorbable sheet and restored with a resin composite. On three and six months after surgery, the teeth were extracted, immersion-fixed and decalcified. Afterward, the teeth were frozen-sectioned, stained with hematoxylin and eosin and observed using a light microscopy. In the experimental group, a large amount of the tertiary dentin was formed into the prepared cavity. On the other hand, the tertiary dentin was almost not formed into the cavity in the control group. The significantly tertiary dentin formation was recognized into the prepared cavity when the exposed pulp area had been covered by a bioabsorbable material. This result suggested that the space making by a bioabsorbable material could produce the derivation of pulp tissue and then dentin regeneration into the prepared cavity.

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新規カルボン酸系およびホスホン酸系接着性モノマーを配合した接着システムの接着耐久性

大前正範, 田中久美子, 山田敦子, 高橋圭, 神農泰生, 糸田俊之, 吉山昌弘

日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY 49 20 - 20 2006年4月

Bone formatin induced by recombinant human BMP-2 combined with bioabsorbable material at subperiosteal sites.

Yamaji K, Nishitani Y, Izawa S, Shinno Y, Omae M, Yoshiyama M

J Oral Tissue Engin 4 ( 2 ) 101 - 105 2006年

記述言語：英語出版者・発行元：日本再生歯科医学会

The purpose of this study was to evaluate the effect of bone formation induced by recombinant human BMP-2 (rhBMP-2) combined with bioabsorbable material Kurabio^®AG (AG) at palatal subperiosteal sites in Wistar rats. AG was freeze-dried alginated gel dressing.<BR>Experimental sites were divided into three groups according to the implans : BMP group (rhBMP-2 combined with AG), AG group (AG alone) and Control group.<BR>In every group, infected region or atypical cell proliferation was not observed, and new bone formation was observed at 6 weeks after implantation. Thickness of new bone (TNB) of BMP group was significantly higher than that of AG and Control groups. There was no significant difference in TNB between AG and Control groups.<BR>These results suggest that rhBMP-2 combined with AG have the ability to promote bone formation, although AG alone do not have any effect on bone formation.

DOI： 10.11223/jarde.4.101

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Dentin regeneration by direct pulp capping using a bioabsorbable materials.

Itota T, Tashiro Y, Takagi R, Yamaji K, Shinno Y, Izawa S, Omae M, Yoshiyama M

J Oral Tissue Engin 49 210 - 210 2006年

3.生体吸収性創傷被覆材を用いた象牙質・歯髄複合体の再生(一般口演,第3回日本再生歯科医学会学術大会および総会)

糸田俊之, 田代陽子, 高木了, 山路公造, 神農泰生, 吉山昌宏

日本再生歯科医学会誌 3 ( 1 ) 65 - 65 2005年12月

Fine Deletional Mapping of Chromosome 4q22-35 Region in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

Shinno Yasuo, Gunduz Mehmet, Gunduz Esra, Jia Li-qun, Shimizu Kenji, Yoshiyama Masahiro, Imura Masayuki, Nagai Noriyuki

Journal of hard tissue biology 14 ( 2 ) 326 - 327 2005年10月

記述言語：英語出版者・発行元：硬組織再生生物学会

We analyzed loss of heterozygosity in detail of the long arm of chromosome 4 in 40 oral cancer by using 16 microsatellite markers based on the recent data from human genome sequence and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers D4S2623 and D4S1644 with an allelic deletion of 44% and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5Mbp around the marker, D4S2623. Caspase 6 is just localized 280kb distant from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggest caspase 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

DOI： 10.2485/jhtb.14.326

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その他リンク： http://search.jamas.or.jp/link/ui/2007049583

Identification of Caspase-6 as A Candidate Tumor Suppressor Gene at 4q25 in Oral Cancer(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

Shinno Yasuo, Gunduz Mehmet, Gunduz Esra, Shimizu Kenji, Yoshiyama Masahiro, Yasuoka Akira, Nagai Noriyuki

Journal of hard tissue biology 14 ( 2 ) 328 - 329 2005年10月

記述言語：英語出版者・発行元：硬組織再生生物学会

We recently reported the frequent deletion of chromosome 4q25 region in oral squamous cell carcinoma and discussed the Caspase-6 as a possible tumor suppressor gene in this region due to its near location to this hot spot. We this time examined the role of Caspase-6 in oral cancers. mRNA expression level, protein localization and gene mutation of Caspase-6 were analyzed. Reverse-transcription-PCR analysis demonstrated decreased expression in 40% and equal expression in 30% of Caspase-6 mRNA of primary tumors as compared with that matched normal samples. cDNA sequencing analysis of Caspase-6 did not reveal any somatic mutation. Caspase-6 protein localization was in similar proportion with its mRNA expression. Failure of Caspase-6 response in tumor samples as compared to normal samples could suggest Caspase-6 as a candidate tumor suppressor gene in a subset of oral cancer.

DOI： 10.2485/jhtb.14.328

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その他リンク： http://search.jamas.or.jp/link/ui/2007049584

Fine deletional mapping of chromosome 4q22-35 region in oral cancer

Y Shinno, E Gunduz, M Gunduz, H Nagatsuka, H Tsujigiwa, B Cengiz, YJ Lee, R Tamamura, M Ouchida, K Fukushima, K Shimizu, N Nagai

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 16 ( 1 ) 93 - 98 2005年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PROFESSOR D A SPANDIDOS

We analyzed the loss of heterozygosity of the long arm of chromosome 4 in 40 oral cancers, using 16 microsatellite markers based on data from the human genome sequence, and defined the deletional mapping of the region with putative tumor suppressor genes. Our data revealed two distinct commonly deleted regions around the markers, D4S2623 and D4S1644, with an allelic deletion of 44 and 39%, respectively. Additional mapping and use of the markers near one of these hot spots narrowed down the minimally deleted region about 1.5 Mbp around the marker, D4S2623. Caspase 6 is localized 280 kb from the marker, D4S2623. Fine mapping of this region with possible tumor suppressor gene suggests caspasc 6 as a putative tumor suppressor gene. Further molecular analysis of caspase 6 should be performed to clarify its role in oral carcinogenesis.

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口腔扁平上皮癌におけるCaspase-6の発現

神農泰生, 長塚仁, Gunduz Mehmet, Rodriguez Andrea, Han Phuu, 片瀬直樹, 岡内美佳, 永井教之

日本病理学会会誌 94 ( 1 ) 205 - 205 2005年3月

Multiple osteolytic lesions of the jaws

Han P P, Nagatsuka H, Tsujigiwa H, Gunduz M, Shinno Y, Rodriguez A P, Riveria R S, Nagai N

Oral Medicine & Pathology 2005年

Basaloid squamous cell carcinoma of the tongue in a Japanese male patient: A case report

Yasuo Shinno, Hitoshi Nagatsuka, Chong-Huat Siar, Hidetsugu Tsujigiwa, Ryo Tamamura, Mehmet Gunduz, You-Jin Lee, Akira Sasaki, Noriyuki Nagai

Oral Oncology Extra 41 ( 4 ) 65 - 69 2005年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

Basaloid squamous cell carcinoma (BSCC) is a virulent variant of squamous cell carcinoma. We present a case of BSCC affecting the tongue of a 57-year old Japanese male. Microscopically, BSCC was diagnosed on the basis of presence of basaloid carcinomatous component in intimate contact with smaller areas of conventional squamous cell carcinoma. Immunohistochemistry demonstrated positive staining of tumor epithelium for pan-keratin marker MNF116, CK8, CK17, CK19 and CEA, weak immunoreactivity for CK14, EMA and S-100 protein and negative staining for CK1 and alpha-smooth muscle actin. The principal differential diagnoses considered were adenoid cystic carcinoma, adenosquamous carcinoma and polymorphous low-grade adenocarcinoma. © 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ooe.2004.12.002

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Distribution of calbindin D-28k in odontoblasts after cavity preparation in human teeth.

Tashiro Y, Itota T, Takagi R, Shinno Y, Yoshiyama M

Journal of Oral Tissue Engineering 2005年

Epigenetic and Genetic Modifications of BRG1Gene Promotes Oral Cancer Development

Esra Gunduz, Mehmet Gunduz, 長塚仁, 辻極秀次, 神農泰生, 中野敬介, 永井教之

Journal of oral biosciences 46 ( 5 ) 421 - 421 2004年9月

Loss of Heterozygosity Analysis of Chromosomal 2q22-37 Region in Oral Cancers(Asian Science Seminar/III-2, The 3^<rd> Asian Science Seminar)

Cengiz Beyhan, Gunduz Mehmet, Nagatsuka Hitoshi, Gunduz Esra, Tsujigiwa Hidetsugu, Shinno Yasuo, Tamamura Ryo, Nagai Noriyuki

Journal of hard tissue biology 13 ( 2 ) 99 - 99 2004年9月

口腔扁平上皮癌における癌抑制遺伝子候補としてのCaspase-6の検討

神農泰生, 長塚仁, Gunduz Esra, Gunduz Mehmet, 辻極秀次, 玉村亮, 清水憲二, 永井教之

Journal of Oral Biosciences 46 ( 5 ) 422 - 422 2004年9月

7.エナメル上皮腫におけるAmelogenin遺伝子(AMELX,AMELY)発現の解析(第12回硬組織生物学会学術大会)

プーハン, 辻極秀次, 長塚仁, 大井田新一郎, エスラグンデゥズ, 玉村亮, 神農泰生, アンドレアロドリゲス, 永井敏之

Journal of hard tissue biology 12 ( 3 ) 93 - 93 2004年3月

口腔扁平上皮癌における癌抑制遺伝子候補の研究(その2) 癌抑制遺伝子候補としてのCaspase-6の検討.

神農泰生, GunduzMehmet, 長塚仁, GunduzEsra, 辻極秀次, 清水憲二, 永井教之

Journal of Hard Tissue Biology. 12 ( 3 ) 82 - 87 2004年

記述言語：日本語出版者・発行元：硬組織再生生物学会

前報より、4q25(D4S2623)において、高頻度のLOHが認められ、この領域にCaspase-6遺伝子が存在していることが確認された。Caspase-6遺伝子はアポトーシスに関連する遺伝子であり、癌抑制遺伝子として機能する可能性が十分に考えられる。そこで我々は、Caspase-6 mRNAの発現量を正常組織、腫瘍組織で比較し、解析した。40%の症例で、腫瘍組織におけるCaspase-6 mRNA発現量の低下が認められた。同様に30%の症例で変化が見られなかった。同時に、Caspase-6遺伝子における変異の解析を行った。Caspase-6 cDNA塩基配列解析の結果、いかなる変異も認められなかった。以上より、少なくとも一部の口腔扁平上皮癌の癌化のメカニズムにはCaspase-6遺伝子が関与していると考えられ、癌抑制遺伝子候補である可能性が示唆された。

DOI： 10.2485/jhtb.12.82

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その他リンク： http://search.jamas.or.jp/link/ui/2004215644

ヒト歯胚と歯原性腫瘍基底膜におけるIV型コラーゲンα鎖の局在に関する免疫組織化学的研究.

藤井英貴, 長塚仁, You-Jin Lee, 神農泰生, 玉村亮, Jing Xiao, 内藤一郎, 佐渡義一, 中川敏浩, 永井教之

J Hard Tissue Biol 13 ( 3 ) 111 - 115 2004年

記述言語：日本語出版者・発行元：硬組織再生生物学会

Type IV collagen, the major component of basement membrane (BM), demonstrates a stage- and position-specific distribution of its isoforms during tooth development. To determine its localization in BM of malignant odontogenic neoplasms, immunohistochemistry using six anti-alpha(IV) chain-specific monoclonal antibodies was performed. Results disclosed that BM demonstrated an irregular alpha(IV) chain profile in tooth germ as compared to benign odontogenic neoplasms. No alpha3(IV) chains were detected. Expression of alpha1(IV)/alpha2(IV) and alpha4(IV), alpha5(IV)/alpha6(IV) chains was ameloblastic fibro-odontosarcoma, but not the inductive hard tissues. Ameloblastic carcinoma showed specific alpha1 (IV)/alpha2(IV) chain loss, while primary intraosseous carcinoma demonstrated a discontinuous alpha1 (IV)/alpha2(IV) and alpha5(IV)/alpha6(IV) staining pattern. The present results suggest that modification and remodeling of BM collagen IV alpha chains occur during malignant odontogenic neoplasms' progression.

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論文 - 神農 泰生

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論文 - 神農　泰生