Faculty Profiles - ITO Takehiko

MISC - ITO Takehiko

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Analysis of Aldehydes in Biological Samples

HORIKE T, ITO T, USAMI M, Wang, DH, YAMAMOTO H, KIRA S

産業衛生学雑誌 = Journal of occupational health 43 686 - 686 2001.3

Effect of m-xylene exposure on GABA A receptors

ITO T

産業衛生学雑誌 = Journal of occupational health 43 556 - 556 2001.3

4.m-キシレン曝露の脳内GABA受容体に及ぼす影響(第28回有機溶剤中毒研究会)

伊藤武彦, 中山祥嗣, 瀧川智子, 吉良尚平

産業衛生学雑誌 43 ( 6 ) 227 - 227 2001

Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats

Toshihito Suzuki, Toshihito Suzuki, Shuzo Abe, Mika Yamaguchi, Atsuomi Baba, Takafumi Hori, Hiroyasu Shiraishi, Takehiko Ito

Synapse 38 167 - 176 2000.10

The acute effects of systemic administration of the anti-obesity agent sibutramine on extracellular dopamine (DA) in the nucleus accumbens of freely moving rats were studied using in vivo microdialysis and compared with the actions of phentermine and d-amphetamine at doses 1x and 3x their respective 2 h ED50 values to reduce food intake in rats. At the lower dose, sibutramine did not elevate extracellular DA concentrations; however, at the higher dose (6.0 mg kg-1, i.p.) it caused a modest and prolonged increase in extraneuronal DA. A maximal rise was observed at 60 min post-sibutramine treatment (+231% compared to controls) with DA levels remaining elevated for up to 160 min post treatment. In contrast, phentermine and d-amphetamine significantly enhanced DA efflux at both the lower and higher doses. These elevations of DA levels were significantly greater than that seen with the corresponding dose of sibutramine over 0-80 min post treatment. Maximal rises in DA levels resulting from the higher dose of each drug were +733% (phentermine, 3.9 mg kg-1, i.p.) and +603% (d-amphetamine, 1.5 mg kg-1, i.p.) compared to controls 40 min post treatment. The highest doses of phentermine and d-amphetamine increased rat locomotor activity up to 100 min and 160 min post treatment, respectively, whereas the equivalent sibutramine dose had no effect. These findings therefore suggest that dopaminergic reward mechanisms are not involved in the reduction of food intake by sibutramine. Furthermore, they are consistent with the view that sibutramine lacks abuse potential. (C) 2000 Wiley-Liss, Inc.

DOI： 10.1002/1098-2396(200011)38:2<167::AID-SYN8>3.0.CO;2-W

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Alteration in GABA receptors following xylene exposure to rats and distribution of xylene in their body

ITO T

産業衛生学雑誌 = Journal of occupational health 42 343 - 343 2000.3

4. 有機溶剤乱用のモデル動物作成(第45回労働衛生史研究会)

伊藤武彦, 関明彦, 秀衡隆志, 中山祥嗣, 堀家徳士, 王達紘, 吉良尚平

産業衛生学雑誌 42 ( 1 ) 31 - 31 2000

Measurement of a time-weighted average level (TWA) of benzo (a) pyrene in sea water by blue rayon hanging

NAKAYAMA Shoji, TAKIGAWA Tomoko, NOGAMI Yusaku, ITO Takehiko, HAYATSU Hikoya, KIRA Shohei

日本環境変異原学会大会プログラム・要旨集 ( 29 ) 87 - 87 2000

Effects of acute and chronic phencyclidine administration on the expression of subunit mRNA for NMDA and GABA_A receptors in rat brain

ABE Shuzo, SUZUKI Toshihito, BABA Atsuomi, KURITA Hirofumi, SHIRAISHI Hiroyasu, ITO Takehiko

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 19 ( 6 ) 374 - 374 1999.12

Effect of repeated administration of cocaine on a level of NMDA receptor subunit mRNA in rat brain

SUZUKI Toshihito, ABE Shuzo, YAMAGUCHI Mika, BABA Atsuomi, SHIRAISHI Hiroyasu, ITO Takehiko

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 19 ( 6 ) 383 - 383 1999.12

Time-dependent changes in a level of GABA_A receptor subunit mRNA following cocaine administration

YAMAGUCHI Mika, SUZUKI Toshihito, ABE Shuzo, BABA Atsuomi, SHIRAISHI Hiroyasu, ITO Takehiko

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 19 ( 6 ) 424 - 424 1999.12

各種統計データを生かした小地区分析事業－公衆衛生学的地区調査－

中林圭一, 吉田秋子, 吉良尚平, 今井香織, 伊藤武彦, 関明彦

平成10年度産学連携研究（岡山県保健福祉部保健福祉課；小地区分析検討事業）「各種統計データを生かした小地区分析事業－公衆衛生学的地区調査－」研究報告書 1999

青少年の薬物乱用防止に関する政策と教育－日米比較研究－

伊藤武彦

1997年度（後期）松下国際財団研究助成報告書 1999

Effects of cocaine on the binding sites and subunits mRNA of GABA_A-benzodiazepine (BZD) receptor complexes in rat brain

YAMAGUCHI Mika, SUZUKI Toshihito, ABE Shuzo, BABA Atsuomi, SHIRAISHI Hiroyasu, ITO Takehiko, OKADO Nobuo

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 18 ( 6 ) 387 - 387 1998.12

Differential expression of GABA_A/benzodiazepine receptor subunit mRNA and ligand binding sites in rat brain following phencyclidine administration : An autoradiographic analysis

ABE Shuzo, SUZUKI Toshihito, BABA Atsuomi, KURITA Hirofumi, SHIRAISHI Hiroyasu, ITO Takehiko, OKADO Nobuo

日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology 18 ( 6 ) 311 - 311 1998.12

Changes in Specific Amino Acid Residues and Na^+,K^+ -ATPase Activity in Cell Membranes of Rat Cerebral Cortex by Low Dose X-Irradiation : Changes in Specific Amino Acid Residues and Na^+,K^+ -ATPase Activity in Cell Membranes of Rat Cerebral Cortex by Low Dose X-Irradiation

YAMAOKA Kiyonori, EDAMATSU Rei, ITOH Takehiko, MORI Akitane

Journal of radiation research 35 ( 4 ) 257 - 257 1994

9.Tremor rat脳におけるNa, K-ATPase活性ならびに膜流動性の変化について

伊藤武彦, 片山泰人, 枝松礼, 油布克巳, 森昭胤

日本疾患モデル学会記録 9 ( 0 ) 49 - 49 1993

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