Faculty Profiles - FUJII Nobuharu

MISC - FUJII Nobuharu

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Single-Cell DNA Sequencing Reveals Cell-Level Genetic Evolutionary Processes and Clonal Structure in B-Cell Lymphomas

Hiroyuki Murakami, Ryota Chijimatsu, Hideki Ujiie, Yusuke Naoi, Kazutaka Sunami, Kazuhiko Yamamoto, Soichiro Fujii, Tomofumi Yano, Keisuke Seike, Hideaki Fujiwara, Noboru Asada, Nobuharu Fujii, Ken-ichi Matsuoka, Tomohiro Urata, Kazuhiro Ikeuchi, Hiroki Kobayashi, Yasuharu Sato, Shuta Tomida, Yoshinobu Maeda, Daisuke Ennishi

BLOOD 144 1368 - 1369 2024.11

Dynamic Shifts in Inflammation and Fibrotic Remodeling in Post-HSCT Bronchiolitis Obliterans: A Spatial Transcriptomics Study

Akira Yamamoto, Nobuharu Fujii, Keisuke Seike, Seiichiro Sugimoto, Yusuke Naoi, Yui Kambara, Kanako Fujiwara, Toshiki Terao, Tadashi Oyama, Mari Kunihiro, Takumi Kondo, Hiroki Kobayashi, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Keiko Fujii, Shinichi Toyooka, Yoshinobu Maeda

Blood 2024.11

Language：English

<jats:sec>
<jats:title/>
<jats:p>Bronchiolitis obliterans (BO) is a severe complication following hematopoietic stem cell transplantation (HSCT), significantly impacting patients' prognosis and quality of life. Despite its clinical importance, the underlying pathophysiological mechanisms remain poorly understood.</jats:p>
<jats:p>We analyzed lung specimens from three patients who developed BO post-HSCT and subsequently underwent lung transplantation. All patients had acute lymphoblastic leukemia as their primary disease and developed BO 1-2 years after HSCT. Healthy lung regions from two cancer patients served as controls. Using NanoString GeoMx Digital Spatial Profiling, we performed transcriptional profiling with the Human Whole Transcriptome Atlas on 94 regions of interest (ROIs). BO lesions were classified based on our previously established staging system (Kuroi T et al. Int J Hematol. 2021) and analyzed for both inner and outer bronchiolar regions.</jats:p>
<jats:p>Linear mixed model analysis identified significant differential gene expression between BO and control groups. GO enrichment analysis highlighted biological processes such as phagocytosis, positive regulation of leukocyte activation, and cell activation, indicating a close association with immune cells, particularly macrophages, which are known to obstruct bronchioles in BO. Processes such as regulation of cell-cell adhesion and post-Golgi vesicle-mediated transport were also enriched, suggesting involvement in extracellular matrix remodeling and fibroblast activation. GSEA further identified significant processes, including inflammatory response, defense response, positive regulation of response to stimulus, and vesicle-mediated transport. These results suggest an interplay between immune response and tissue remodeling. Notably, changes in the expression of genes such as HES1, IGF2BP2, PTPRF, and ITGB2, which are involved in cell adhesion and cytoskeletal reorganization, were closely associated with fibroblast activation and macrophage infiltration. These findings parallel the fibrosis process observed in BO following lung transplantation, where macrophage infiltration and myofibroblast activation are critical. Given these insights, our focus shifted to the dynamics of macrophages and myofibroblasts, aiming to understand their roles in the progression from inflammation to tissue remodeling.</jats:p>
<jats:p>CD68, a pan-macrophage marker, showed higher expression in Early and Middle-outside stages (Inflammatory Phase) of BO, but significantly decreased in Middle-inside and Late stages (Remodeling Phase) as the disease progressed. Unsupervised clustering analysis revealed distinct gene expression profiles between these phases, suggesting a temporal shift in disease mechanisms as BO progresses from inner bronchioles outwards. Correlation analysis revealed significant associations between CD68 and JAK1/STAT1 expression, as well as genes associated with myofibroblast activity and extracellular matrix remodeling (e.g., ACTA2, TGFB1). These findings suggest a coordinated process of inflammation and remodeling in BO, potentially involving the JAK-STAT pathway.</jats:p>
<jats:p>Linear mixed model analysis revealed distinct gene expression patterns between Inflammatory and Remodeling Phases, characterized by inflammatory/proliferation-related genes (e.g., CXCL6, HLA-family) and tissue remodeling/protein synthesis and genes (e.g., ITGB1, RPL and RPS families), respectively. This transition aligns with changes in macrophage-related gene expression. Pathway analysis revealed enrichment of translation, ribosomal activity, and metabolic processes in the Remodeling Phase, indicating a dynamic shift in biological activities as BO progresses.</jats:p>
<jats:p>In conclusion, this study reveals a transition in BO pathology from inflammation to remodeling, with macrophages playing a central role. The coordinated changes in gene expression provide a comprehensive picture of BO progression. These insights into post-HSCT BO pathophysiology highlight potential therapeutic targets in macrophage function and tissue remodeling pathways, suggesting possibilities for stage-specific interventions in BO treatment.</jats:p>
</jats:sec>

DOI： 10.1182/blood-2024-202251

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ネララビン関連重症神経障害単一施設での同種造血幹細胞移植にまつわる4症例

藤原加奈子, 藤原英晃, 久保田紗矢, 上田弥生, 林野健太, 近藤歌穂, 松原千哲, 寺尾俊紀, 木村真衣子, 清家圭介, 淺田騰, 西森久和, 藤井敬子, 藤井伸治, 松岡賢市, 前田嘉信

日本血液学会学術集会 85回 1268 - 1268 2023.10

ベネトクラクス,アザシチジンを含む化学療法後に初回同種造血幹移植を施行した急性骨髄性白血病の治療成績

松原千哲, 藤原英晃, 林野健太, 近藤歌穂, 藤原加奈子, 寺尾俊紀, 植田裕子, 松村彰文, 大山矩史, 鴨井千尋, 村上裕之, 守山喬史, 近藤匠, 清家圭介, 淺田騰, 遠西大輔, 西森久和, 藤井敬子, 藤井伸治, 松岡賢市, 前田嘉信

日本血液学会学術集会 85回 1250 - 1250 2023.10

臍帯血移植後にHTLV-1感染T細胞の多クローン性増殖を伴って発症した肺合併症に対し抗CCR4抗体が著効した1例

松原千哲, 松岡賢市, 近藤歌穂, 藤原加奈子, 寺尾俊紀, 植田裕子, 松村彰文, 守山喬史, 村上裕之, 近藤匠, 清家圭介, 藤原英晃, 淺田騰, 遠西大輔, 西森久和, 藤井敬子, 藤井伸治, 前田嘉信

臨床血液 64 ( 6 ) 563 - 563 2023.6

臍帯血移植後にHTLV-1感染T細胞の多クローン性増殖を伴って発症した肺合併症に対しCCR4抗体が著効した一例

松原千哲, 松岡賢市, 近藤歌穂, 藤原加奈子, 寺尾俊紀, 植田裕子, 松村彰文, 守山喬史, 村上裕之, 近藤匠, 清家圭介, 藤原英晃, 淺田騰, 遠西大輔, 西森久和, 藤井敬子, 藤井伸治, 中島誠, 中島誠, 内丸薫, 前田嘉信

日本血液学会学術集会抄録(Web) 85th 656 - 656 2023

Tisagenlecleucelのためのリンパ球採取-末梢血CD3⁺数と採取効率による処理量決定とロングアフェレーシスでの工夫-

藤井敬子, 阿部将也, 住居優一, 谷勝真, 浦田知宏, 高木尚江, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 北村亘, 清家圭介, 大塚文男, 藤井伸治, 藤井敬子, 阿部将也, 住居優一, 谷勝真, 浦田知宏, 高木尚江, 北村亘, 清家圭介, 大塚文男, 藤井伸治

日本輸血細胞治療学会誌 69 ( 2 ) 2023

Clinical significance of gynecological examinations in LTFU

鴨井千尋, 鴨井千尋, 藤井伸治, 藤井伸治, 松岡敬典, 藤原英晃, 淺田騰, 遠西大輔, 西森久和, 藤井敬子, 藤井敬子, 松岡賢市, 前田嘉信

日本造血・免疫細胞療法学会総会プログラム・抄録集 44th 2022

Analysis of cryopreserved unrelated donor bone marrow transplantation under the COVID-19 pandemic

松村彰文, 藤原英晃, 植田裕子, 守山喬史, 村上裕之, 住井優一, 浦田知宏, 木村真衣子, 近藤匠, 浅田騰, 遠西大輔, 西森久和, 松岡賢市, 藤井敬子, 藤井伸治, 鴨井千尋, 前田嘉信

日本造血・免疫細胞療法学会総会プログラム・抄録集 44th 2022

Modification of post-transplant cyclophosphamide and tacrolimus in haploidentical transplantation

寺尾俊紀, 松岡賢市, 近藤匠, 高須賀裕樹, 鴨井千尋, 植田裕子, 松村彰文, 松原千哲, 近藤歌穂, 藤原英晃, 淺田騰, 遠西大輔, 西森久和, 藤井敬子, 藤井伸治, 前田嘉信

日本造血・免疫細胞療法学会総会プログラム・抄録集 45th 2022

Influence of oral microbiota on graft-versus-host disease and its role as a therapeutic target

神原由依, 藤原英晃, 山本晃, 國廣まり, 大山矩史, 近藤匠, 淺田騰, 遠西大輔, 西森久和, 藤井伸治, 藤井敬子, 松岡賢市, 前田嘉信, 前田嘉信

日本造血・免疫細胞療法学会総会プログラム・抄録集 45th 2022

Gilteritinib maintenance therapy post-SCT improves the prognosis of patients with R/R FLT3mut AML

寺尾俊紀, 松岡賢市, 植田裕子, 松村彰文, 松原千哲, 近藤歌穂, 近藤匠, 藤原英晃, 淺田騰, 遠西大輔, 西森久和, 藤井敬子, 藤井伸治, 前田嘉信

日本造血・免疫細胞療法学会総会プログラム・抄録集 45th 2022

Open-label, randomized study to calcium drink for prevention of citrate toxicity of PBSC donor

藤井敬子, 藤井敬子, 藤井伸治, 藤井伸治, 三橋利晴, 住居優一, 住居優一, 谷勝真, 谷勝真, 浦田知宏, 浦田知宏, 木村真衣子, 木村真衣子, 近藤匠, 藤原英晃, 淺田騰, 遠西大輔, 西森久和, 松岡賢市, 大塚文男, 前田嘉信

日本造血・免疫細胞療法学会総会プログラム・抄録集 45th 2022

Prognostic impact of Day 30 WT1 after PTCY-haplo in myeloid neoplasm: A multi-center study from OHSG

北村亘, 藤井伸治, 藤井伸治, 名和由一郎, 杉浦弘幸, 藤下惠悟, 吉岡尚徳, 藤原悠紀, 大山矩史, 村上裕之, 高須賀裕樹, 池内一廣, 池川俊太郎, 池川俊太郎, 藤原英晃, 淺田騰, 遠西大輔, 遠西大輔, 西森久和, 藤井敬子, 松岡賢市, 木口亨, 今井利, 平松靖史, 前田嘉信

日本血液学会学術集会抄録(Web) 83rd 2021

EBV viremia with NK/T cells as well as B cells after hematopoietic stem cell transplantation

大山矩史, 西森久和, 村上裕之, 高須賀裕樹, 北村亘, 藤原英晃, 淺田騰, 藤井敬子, 藤井伸治, 遠西大輔, 松岡賢市, 前田嘉信

日本血液学会学術集会抄録(Web) 83rd 2021

移植後シクロホスファミドを用いた血縁者間HLA半合致移植後に最重症遅発性肝類洞閉塞症候群を合併した非定型慢性骨髄性白血病

北村亘, 藤井伸治, 藤井伸治, 大西秀樹, 高須賀裕樹, 大山矩史, 村上裕之, 木村真衣子, 近藤匠, 松田真幸, 池川俊太郎, 池川俊太郎, 藤原英晃, 淺田騰, 遠西大輔, 遠西大輔, 西森久和, 藤井敬子, 藤井敬子, 松岡賢市, 木口亨, 柳井広之, 吉野正, 前田嘉信

臨床血液 62 ( 6 ) 654 - 655 2021

Marfan症候群に先天性第XI因子欠乏症とvon Willebrand病(VWD)を合併した患者の心臓弁膜症手術の周術期管理

大山矩史, 淺田騰, 末澤孝徳, 新谷憲治, 廣田真規, 池内一廣, 北村亘, 高須賀裕樹, 藤原英晃, 遠西大輔, 西森久和, 藤井伸治, 松岡賢市, 笠原真悟, 前田嘉信

臨床血液 62 ( 6 ) 663 - 663 2021

Efficacy of HLA virtual cross-matched platelet transfusions for platelet transfusion refractoriness in hematopoietic stem cell transplantation (vol 60, pg 473, 2020)

Keisuke Seike, Nobuharu Fujii, Naomi Asano, Shigenori Ohkuma, Yasushi Hirata, Keiko Fujii, Yasuhisa Sando, Makoto Nakamura, Kazunori Naito, Yusuke Meguri, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken-ichi Matsuoka, Kazuo Tsubaki, Fumio Otsuka, Yoshinobu Maeda

TRANSFUSION 60 ( 11 ) 2765 - 2765 2020.11

同種骨髄移植が有用であった大脳型に進展した副腎白質ジストロフィーの1例

表芳夫, 佐藤恒太, 浦田知宏, 藤井伸治, 下澤伸行, 山下徹, 武本麻美, 菱川望, 太田康之, 阿部康二

臨床神経学 60 ( Suppl. ) S416 - S416 2020.11

原発性マクログロブリン血症から形質転換したGerminal Center B-cellタイプのびまん性大細胞型B細胞リンパ腫の症例

小林宏紀, 淺田騰, 遠西大輔, 阿部将也, 池田知佳, 坂本美彩, 江草侑厘安, 廻勇輔, 西森久和, 藤井伸治, 松岡賢市, 佐藤康晴, 吉野正, 前田嘉信

日本リンパ網内系学会会誌 60 82 - 82 2020.7

繰り返しセルブロック標本を作製することにより原発性滲出性リンパ腫様リンパ腫と診断した1例

長谷井稜子, 佐住洋祐, 徳増一樹, 長谷川功, 萩谷英大, 藤井伸治, 花山宜久, 大塚文男

日本病院総合診療医学会雑誌 16 ( 臨増1 ) 166 - 166 2020.2

造血幹細胞運搬条件設定に関する取り組み

浅野尚美, 小郷博昭, 池田亮, 閘結稀, 高木尚江, 清家圭介, 三道康永, 中村真, 藤井敬子, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 66 ( 1 ) 78 - 78 2020.2

肝膿瘍を合併した急性骨髄性白血病の造血幹細胞移植時に顆粒球輸注が有効であった1例

谷岡桃子, 福見拓也, 神原由依, 池内一廣, 小林宏紀, 廻勇輔, 淺田騰, 遠西大輔, 西森久和, 藤井伸治, 松岡賢市, 前田嘉信

臨床血液 61 ( 10 ) 1529 - 1529 2020

Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood

Seitaro Terakura, Tetsuya Nishida, Masashi Sawa, Tomonori Kato, Kotaro Miyao, Yukiyasu Ozawa, Tatsunori Goto, Akio Kohno, Kazutaka Ozeki, Yasushi Onishi, Noriko Fukuhara, Nobuharu Fujii, Hisayuki Yokoyama, Masanobu Kasai, Hiroatsu Iida, Nobuhiro Kanemura, Tomoyuki Endo, Hiroatsu Ago, Makoto Onizuka, Satoshi Iyama, Yuichiro Nawa, Mika Nakamae, Yasuyuki Nagata, Shingo Kurahashi, Yasuo Tomiya, Atsumi Yanagisawa, Ritsuro Suzuki, Yachiyo Kuwatsuka, Yoshiko Atsuta, Koichi Miyamura, Makoto Murata

BLOOD 134 2019.11

急性骨髄性白血病に対する臍帯血移植後に発症しバンコマイシン髄注と顆粒球輸注が有効であったEnterococcus faecium髄膜炎の1例

上田弥生, 水原健太郎, 松岡賢市, 阿部将也, 浦田知宏, 神原由依, 住居優一, 藤原悠紀, 佐伯恭昌, 廻勇輔, 淺田騰, 遠西大輔, 西森久和, 藤井伸治, 前田嘉信

臨床血液 60 ( 5 ) 508 - 508 2019.5

二度の同種造血幹細胞移植に続く脳死肺移植後に骨髄異形成症候群を発症し臍帯血移植を施行した1例

伊藤啓, 藤原悠紀, 住居優一, 阿部将也, 水原健太郎, 浦田知宏, 佐伯恭昌, 廻勇輔, 淺田騰, 遠西大輔, 西森久和, 松岡賢市, 藤井伸治, 前田嘉信

臨床血液 60 ( 5 ) 511 - 511 2019.5

Cyclophosphamide(CY)が奏効した難治性TAFRO症候群の一例

浦田知宏, 遠西大輔, 水原健太郎, 阿部将也, 住居優一, 藤原悠紀, 佐伯恭昌, 廻勇輔, 淺田騰, 西森久和, 藤井伸治, 藤井敬子, 佐藤康晴, 松岡賢市, 吉野正, 前田嘉信

日本リンパ網内系学会会誌 59 141 - 141 2019.5

EBV陽性びまん性大細胞型B細胞リンパ腫に対する化学療法施行後に血管免疫芽球性T細胞リンパ腫を発症した1例

渡邊真衣, 水原健太郎, 遠西大輔, 阿部将也, 住居優一, 浦田知宏, 藤原悠紀, 佐伯恭昌, 廻勇輔, 淺田騰, 西森久和, 松岡賢市, 藤井伸治, 吉野正, 前田嘉信

日本リンパ網内系学会会誌 59 153 - 153 2019.5

自家と同種におけるCD34陽性細胞回収率の違いからみた処理量決定末梢血幹細胞採取を効率よく終わらせるために

藤井敬子, 藤井伸治, 清家圭介, 三道康永, 中村真, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 高木尚江, 大塚文男

日本輸血細胞治療学会誌 65 ( 2 ) 349 - 349 2019.4

消化管出血(静脈瘤破裂を除く)の予後不良症例の検討急性消化管GVHDにおいて回腸末端の内視鏡所見は予後・重症度・治療反応性と関連するか?

杉原雄策, 平岡佐規子, 安富絵里子, 岡昌平, 山崎泰史, 井口俊博, 衣笠秀明, 高原政宏, 原田馨太, 藤井伸治, 田中健大, 岡田裕之

日本消化管学会雑誌 3 ( Suppl. ) 161 - 161 2019.2

アルブミン製剤の輸血部管理による使用目的の把握について

小郷博昭, 浅野尚美, 池田亮, 閘結稀, 清家圭介, 三道康永, 中村真, 高木尚江, 藤井敬子, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 64 ( 6 ) 834 - 835 2018.12

Efficacy of HLA-Matched PLT Transfusions for Platelet Transfusion Refractoriness in HSCT Patients

Keisuke Seike, Nobuharu Fujii, Keiko Fujii, Yasuhisa Sando, Makoto Nakamura, Kyosuke Saeki, Yusuke Meguri, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken-Ichi Matsuoka, Yoshinobu Maeda

BLOOD 132 2018.11

PD-1阻害薬使用後の自家造血幹細胞移植におけるサイトカイン放出症候群の病態解析(Mechanistic analysis of cytokine release syndrome after autologous HSCT following PD-1 blockade)

碓井喜明, 松岡賢市, 廻勇輔, 岩本美紀, 三道康永, 坂本真衣子, 藤原悠紀, 近藤匠, 谷勝真, 佐伯恭昌, 岡本幸代, 淺田騰, 西森久和, 藤井伸治, 近藤英生, 前田嘉信

臨床血液 59 ( 9 ) 1542 - 1542 2018.9

造血幹細胞移植における患者指定適合血小板輸血の有効性についての検討(Efficacy of HLA-matched PLT transfusion for platelet transfusion refractoriness in HSCT patients)

清家圭介, 藤井伸治, 藤井敬子, 三道康永, 中村真, 佐伯恭昌, 廻勇輔, 淺田騰, 遠西大輔, 西森久和, 松岡賢市, 前田嘉信

臨床血液 59 ( 9 ) 1541 - 1541 2018.9

Marginal zone B cell lymphoma治療後に、複視を契機にneurolymphomatosisとして再発したと考えられる1例

松田真幸, 坂本真衣子, 碓井喜明, 藤原悠紀, 近藤匠, 谷勝真, 佐伯恭昌, 廻勇輔, 岡本幸代, 西森久和, 近藤英生, 藤井伸治, 松岡賢市, 前田嘉信, 吉野正

臨床血液 59 ( 5 ) 632 - 632 2018.5

乳房腫脹を契機に診断されたperipheral T-cell lymphoma、with T follicular helper phenotypeの1例

碓井喜明, 松岡賢市, 近藤匠, 坂本真衣子, 谷勝真, 藤原悠紀, 佐伯恭昌, 廻勇輔, 淺田騰, 岡本幸代, 西森久和, 近藤英生, 藤井伸治, 吉野正, 前田嘉信

臨床血液 59 ( 5 ) 633 - 633 2018.5

同種末梢血幹細胞移植後3年で抗リン脂質抗体症候群を発症した1例

近藤匠, 碓井喜明, 松岡賢市, 坂本真衣子, 谷勝真, 藤原悠紀, 佐伯恭昌, 廻勇輔, 岡本幸代, 西森久和, 近藤英生, 藤井伸治, 前田嘉信

臨床血液 59 ( 5 ) 642 - 642 2018.5

急性消化管GVHDの診断における上部消化管内視鏡検査と大腸内視鏡検査の比較

杉原雄策, 平岡佐規子, 加藤諒, 高嶋志保, 山崎泰史, 井口俊博, 高原政宏, 原田馨太, 藤井伸治, 田中健大, 岡田裕之

Gastroenterological Endoscopy 60 ( Suppl.1 ) 772 - 772 2018.4

Granulocyte Transfusions for Neutropenic Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Shuntaro Ikegawa, Nobuharu Fujii, Keiko Fujii, Yusuke Meguri, Kyosuke Saeki, Noboru Asada, Hisakazu Nishimori, Ken-ichi Matsuoka, Yoshinobu Maeda

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 24 ( 3 ) S326 - S326 2018.3

Granulocyte Transfusions for Neutropenic Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Shuntaro Ikegawa, Nobuharu Fujii, Keiko Fujii, Yusuke Meguri, Kyosuke Saeki, Noboru Asada, Hisakazu Nishimori, Ken-ichi Matsuoka, Yoshinobu Maeda

BLOOD 130 2017.12

大腸内視鏡を用いた急性GVHDの診断における「回腸末端の絨毛の萎縮」の臨床的意義後方視的多施設共同研究

杉原雄策, 平岡佐規子, 高嶋志保, 竹井大介, 井口俊博, 高原政宏, 森藤由紀, 高橋索真, 桑木健志, 原田馨太, 藤井伸治, 田中健大, 岡田裕之

Gastroenterological Endoscopy 59 ( Suppl.2 ) 2238 - 2238 2017.9

極めて大量のフェントラミン持続静注を要した終末期悪性褐色細胞腫の一例

灘隆宏, 木村耕介, 花山宜久, 藤井伸治, 近藤英生, 大塚文男

日本病院総合診療医学会雑誌 13 ( 1 ) 119 - 119 2017.7

赤血球プライム下の骨髄濃縮小児科、低体重児における骨髄処理

藤井敬子, 中村真, 谷勝真, 佐伯恭昌, 高木尚江, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 今田昌秀, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 63 ( 3 ) 424 - 424 2017.6

健常人ドナー末梢血幹細胞採取時のクエン酸中毒発現、電解質異常についての解析

中村真, 藤井敬子, 佐伯恭昌, 谷勝真, 黒井大雅, 高木尚江, 猪股知子, 池川俊太郎, 杉浦弘幸, 池田直人, 浅野豪, 吉田将平, 西森久和, 松岡賢市, 近藤英生, 前田嘉信, 藤井伸治, 谷本光音

臨床血液 58 ( 5 ) 553 - 553 2017.5

成長ホルモン治療中に多血症およびMDSを合併した一例

当真貴志雄, 越智可奈子, 細谷武史, 藤澤諭, 西山悠紀, 原孝行, 稲垣兼一, 和田淳, 藤井伸治, 大塚文男

日本内分泌学会雑誌 93 ( 1 ) 316 - 316 2017.4

Impact of Incomplete Blood Count Recovery Prior to Allogeneic Hematopoietic Stem Cell Transplantation on Engraftment and Early Infection in Patients with Acute Myeloid Leukemia

Takeru Asano, Shuntaro Ikegawa, Tomoko Inomata, Naoto Ikeda, Hiroyuki Sugiura, Taiga Kuroi, Shohei Yoshida, Hisakazu Nishimori, Ken-ichi Matsuoka, Nobuharu Fujii, Eisei Kondo, Yoshinobu Maeda, Mitsune Tanimoto

BLOOD 128 ( 22 ) 2016.12

Intrabone Transplantation of a Single Cord Blood Unit Using Non-Irradiated Reduced-Intensity Conditioning

Makoto Murata, Yoshinobu Maeda, Masayoshi Masuko, Yasushi Onishi, Tomoyuki Endo, Seitaro Terakura, Yuichi Ishikawa, Chisako Iriyama, Yoko Ushijima, Tatsunori Goto, Nobuharu Fujii, Mitsune Tanimoto, Hironori Kobayashi, Yasuhiko Shibasaki, Noriko Fukuhara, Yoshihiro Inamoto, Ritsuro Suzuki, Tadashi Matsushita, Yoshihisa Kodera, Hitoshi Kiyoi, Tomoki Naoe, Tetsuya Nishida

BLOOD 128 ( 22 ) 2016.12

Successful Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Mild Renal Dysfunction Calculated By Creatinin Clearance

Shuntaro Ikegawa, Tomoko Inomata, Naoto Ikeda, Hiroyuki Sugiura, Taiga Kuroi, Takeru Asano, Shohei Yoshida, Hisakazu Nishimori, Ken-ichi Matsuoka, Nobuharu Fujii, Eisei Kondo, Yoshinobu Maeda, Mitsune Tanimoto

BLOOD 128 ( 22 ) 2016.12

シミュレーションを用いた輸血当直業務トレーニング

浅野尚美, 小郷博昭, 池田亮, 閘結稀, 高木尚江, 中村真, 谷勝真, 佐伯恭昌, 藤井敬子, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 62 ( 6 ) 756 - 757 2016.12

Spectra Optiaを用いた骨髄濃縮小児科、低体重児における骨髄処理

藤井敬子, 中村真, 谷勝真, 佐伯恭昌, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 今田昌秀, 高木尚江, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 62 ( 6 ) 754 - 754 2016.12

Terminal Ileum Imaging With Colonoscopy Is Marker for Evaluation of Acute Graft-Versus-Host Disease Severity After Allogeneic Bone Marrow Transplantation

Yuusaku Sugihara, Sakiko Hiraoka, Shiho Takashima, Daisuke Takei, Toshihiro Inokuchi, Asuka Nakarai, Masahiro Takahara, Kenji Kuwaki, Keita Harada, Nobuharu Fujii, Takehiro Tanaka, Hiroyuki Okada

GASTROINTESTINAL ENDOSCOPY 83 ( 5 ) AB325 - AB325 2016.5

リンパ節、肺・心嚢への進展を伴った皮膚原発ALK陰性ALCLの1例

為房宏輔, 猪股知子, 松岡賢市, 吉田将平, 西森久和, 近藤英生, 藤井伸治, 前田嘉信, 谷本光音

臨床血液 57 ( 5 ) 663 - 663 2016.5

同種骨髄移植後にBKウイルス性出血性膀胱炎に罹患し、両側腎瘻・膀胱瘻造設術を要した骨髄異形成症候群の1症例

鴨井千尋, 三道康永, 藤井伸治, 吉田将平, 西森久和, 松岡賢市, 近藤英生, 前田嘉信, 谷本光音, 児島宏典, 森聰博, 藤尾圭, 堀川雄平, 松本裕子, 和田耕一郎, 那須保友

臨床血液 57 ( 5 ) 669 - 669 2016.5

Analysis of Prognostic Factors of Hematopoietic Stem Cell Transplantation Patients Admitted to ICU

Malcoto Nakamura, Nobuharu Fujii, Kazuyoshi Shimizu, Hisakazu Nishimori, Ken-ichi Matsuoka, Eisei Kondo, Yoshinobu Maeda, Hiroshi Morimatsu, Mitsune Tanimoto

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 22 ( 3 ) S293 - S293 2016.3

Magnifying Endoscopic Features of Follicular Lymphoma Involving the Stomach: A Report of Two Cases

Masaya Iwamuro, Katsuyoshi Takata, Seiji Kawano, Nobuharu Fujii, Yoshiro Kawahara, Tadashi Yoshino, Hiroyuki Okada

CASE REPORTS IN GASTROINTESTINAL MEDICINE 2016 1 - 6 2016

Language：English Publisher：HINDAWI LTD

A 70-year-old woman presented with follicular lymphoma involving the stomach, duodenum, jejunum, bone, and lymph nodes. Esophagogastroduodenoscopy revealed multiple depressed lesions in the stomach. Examination with magnifying endoscopy showed branched abnormal vessels along with gastric pits, which were irregularly shaped but were preserved. The second case was a 45-year-old man diagnosed with stage II 1 follicular lymphoma with duodenal, ileal, and colorectal involvement, as well as lymphadenopathy of the mesenteric lymph nodes. Esophagogastroduodenoscopy performed six years after the diagnosis revealed multiple erosions in the gastric body and angle. Magnifying endoscopic observation with narrow-band imaging showed that the gastric pits were only partially preserved and were destroyed in most of the stomach. Branched abnormal vessels were also seen. Pathological features were consistent with follicular lymphoma in both cases. The structural differences reported between the two cases appear to reflect distinct pathologies. Disappearance of gastric pits in the latter case seems to result from loss of epithelial cells, probably due to chronic inflammation. In both cases, branched abnormal vasculature was observed. These two cases suggest that magnified observations of abnormal branched microvasculature may facilitate endoscopic detection and recognition of the extent of gastric involvement in patients with follicular lymphoma.

DOI： 10.1155/2016/2082698

Web of Science

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Terminal ileum imaging with colonoscopy to evaluate acute graft-versus-host disease severity after allogeneic bone marrow transplantation

Yuusaku Sugihara, Sakiko Hiraoka, Shiho Takashima, Daisuke Takei, Inokuchi Toshihiro, Asuka Nakarai, Masahiro Takahara, Keita Harada, Hiroyuki Okada, Nobuharu Fujii

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 30 172 - 172 2015.12

輸血当直における各業務過程の所要時間Turn-around Time(TAT)についての検討

小郷博昭, 浅野尚美, 池田亮, 閘結稀, 石川立則, 吉岡尚徳, 小林優人, 高木尚江, 藤井敬子, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 61 ( 6 ) 590 - 590 2015.12

末梢血幹細胞採取時の健常人ドナーにおけるクエン酸中毒発現、電解質異常についての解析

藤井敬子, 石川立則, 吉岡尚徳, 廻勇輔, 藤原英晃, 小林優人, 高木尚江, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 61 ( 6 ) 593 - 593 2015.12

慢性活動性EBウイルス感染症に対して同種移植を行った5例

三道康永, 藤原英晃, 西森久和, 松岡賢市, 近藤英生, 藤井伸治, 前田嘉信, 谷本光音

日本リンパ網内系学会会誌 55 107 - 107 2015.6

イマチニブ療法に対して難治性であったRosai-Dorfman病の2症例症例報告と文献考察(Two cases of Rosai-Dorfman Disease refractory to Imatinib therapy: Case report and review of literature)

谷勝真, 藤井伸治, 石川立則, 山本宣和, 塩手康弘, 佐伯恭昌, 清家圭介, 三道康永, 中村真, 藤原英晃, 西森久和, 松岡賢市, 近藤英生, 前田嘉信, 谷本光音, 高田尚良, 吉野正

日本リンパ網内系学会会誌 55 97 - 97 2015.6

限局期CD5陽性びまん性大細胞型B細胞リンパ腫の治療成績についての検討

中村真, 藤原英晃, 清家圭介, 三道康永, 石川立則, 西森和久, 松岡賢市, 近藤英生, 藤井伸治, 前田嘉信, 谷本光音

日本リンパ網内系学会会誌 55 101 - 101 2015.6

皮膚病変を契機にtrisomy 8を含む複雑核型染色体異常を伴うMDSが判明し、VP-16が奏効したSweet病の1例

藤原暖, 土井裕子, 加持達弥, 濱田利久, 岩月啓氏, 三道康永, 佐伯恭昌, 藤井伸治, 川上佳夫

西日本皮膚科 77 ( 3 ) 305 - 305 2015.6

ADVIA2120を用いたRDWおよびHDWによる大球性貧血疾患の鑑別

今田昌秀, 日野佳弥, 青江伯規, 高橋孝英, 狩山由貴, 榊原佳奈枝, 渡部俊幸, 藤井伸治, 谷本光音

日本検査血液学会雑誌 16 ( 学術集会 ) S165 - S165 2015.6

当院において集中治療を要した造血幹細胞移植症例についての検討

中村真, 藤井伸治, 清家圭介, 三道康永, 石川立則, 藤原英晃, 西森和久, 松岡賢市, 近藤英生, 前田嘉信, 谷本光音

臨床血液 56 ( 5 ) 539 - 539 2015.5

CNS浸潤伴う治療抵抗性ALK陽性ALCLに対しCrizotinibを使用した1例

濱崎豊, 石川立則, 近藤英生, 吉野正, 長谷川詠子, 瀬崎伸夫, 藤原英晃, 西森久和, 松岡賢市, 藤井伸治, 前田嘉信, 谷本光音

臨床血液 56 ( 5 ) 527 - 528 2015.5

自家末梢血造血幹細胞移植の前処置において、抗がん剤投与量はBMIに応じて増減すべきか

谷勝真, 藤原英晃, 西森久和, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 谷本光音, 廻勇輔, 小林優人, 藤井敬子

臨床血液 56 ( 5 ) 537 - 537 2015.5

造血幹細胞移植後thrombotic microangiopathyに対するrecombinant thrombomodulin投与とその意義

藤原英晃, 前田嘉信, 三道康永, 中村真, 谷勝真, 石川隆則, 西森久和, 松岡賢市, 藤井伸治, 近藤英生, 谷本光音

臨床血液 56 ( 5 ) 534 - 534 2015.5

同種造血幹細胞移植とGranulicatella adiacens敗血症

三道康永, 松岡賢市, 谷勝真, 能勢資子, 藤原英晃, 西森久和, 近藤英生, 藤井伸治, 前田嘉信, 谷本光音

臨床血液 56 ( 5 ) 538 - 538 2015.5

難治性Sweet病を合併したMDSに対して同種造血幹細胞移植を施行した1例

本倉恵美, 三道康永, 佐伯恭昌, 藤井伸治, 藤原英晃, 西森久和, 松岡賢市, 近藤英生, 前田嘉信, 谷本光音, 廻勇輔, 小林優人, 藤井敬子, 藤原暖, 土井裕子, 加持達弥, 岩月啓氏

臨床血液 56 ( 5 ) 538 - 538 2015.5

血液疾患患者におけるHLA適合血小板輸血後の有効性評価

藤井伸治, 小郷博昭, 小林優人, 藤井敬子, 近藤英生, 浅野尚美, 池田亮, 山川美和, 高木尚江, 平田康司

日本輸血細胞治療学会誌 61 ( 2 ) 258 - 258 2015.4

Anti-IL-12/23 p40 Antibody Attenuates Chronic Graft Versus Host Disease Via Suppression of IFN-gamma/IL-17-Producing Cells

Taiga Kuroi, Sachiyo Okamoto, Kyosuke Saeki, Yujin Kobayashi, Hisakazu Nishimori, Hideaki Fujiwara, Ken-ichi Matsuoka, Nobuharu Fujii, Eisei Kondo, Mitsune Tanimoto, Yoshinobu Maeda

BLOOD 124 ( 21 ) 2014.12

Use of Recombinant Thrombomodulin for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation Ameliorate Disease Severity

Hideaki Fujiwara, Yoshinobu Maeda, Yasuhisa Sando, Makoto Nakamura, Katsuma Tani, Takanori Ishikawa, Hisakazu Nishimori, Ken-ichi Matsuoka, Nobuharu Fujii, Eisei Kondo, Mitsune Tanimoto

BLOOD 124 ( 21 ) 2014.12

治療抵抗性DLBCLの自己末梢血幹細胞移植併用大量化学療法(HDT/ASCT)後の再発に対しHLA半合致同種造血幹細胞移植(haploHSCT)を行い完全寛解となった一例

塩手康弘, 近藤英生, 石川立則, 佐伯恭昌, 谷勝真, 山本宜和, 松岡賢市, 西森久和, 藤井伸治, 前田嘉信, 谷本光音, 吉野正

日本リンパ網内系学会会誌 54 122 - 122 2014.6

皮膚γδT細胞リンパ腫に対し臍帯血移植を施行した一例

佐伯恭昌, 石川立則, 谷勝真, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 谷本光音

日本リンパ網内系学会会誌 54 121 - 121 2014.6

当院における70歳以上の高齢血液疾患患者に対する同種造血幹細胞移植

近藤正太郎, 前田嘉信, 松岡賢市, 品川克至, 藤井敬子, 藤井伸治, 近藤英生, 谷本光音

日本老年医学会雑誌 51 ( 3 ) 293 - 293 2014.5

マウス慢性GVHDモデルにおけるPD-1経路の重要性

藤原英晃, 前田嘉信, 西之原正昭, 岡本幸代, 西森久和, 松岡賢市, 藤井伸治, 近藤英生, 品川克至, 谷本光音

日本造血細胞移植学会総会プログラム・抄録集 36th 2014

健常人ドナー末梢血幹細胞採取時における副作用、電解質異常について

藤井敬子, 淺田騰, 藤原英晃, 山川美和, 熊本貴子, 狩山由貴, 池田亮, 浅野尚美, 小郷博昭, 藤井伸治, 岩月啓氏

日本輸血細胞治療学会誌 59 ( 6 ) 865 - 865 2013.12

多発転移に伴い血小板減少をきたした頭部血管肉腫の1例

瀧口徹也, 山崎修, 牧野麻貴, 佐伯泰昌, 藤井伸治, 岩月啓氏

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 29回 128 - 128 2013.8

MTX中止直後に一過性の白血球増多を認め、その後自然退縮したMTX-LPDの一例

近藤英生, 葛島清隆, 市村浩一, 前田嘉信, 藤井伸治, 松岡賢市, 品川克至, 長谷川詠子, 黒井大雅, 佐伯恭昌, 浅野豪, 高田尚良, 佐藤康晴, 吉野正, 谷本光音

日本リンパ網内系学会会誌 53 133 - 133 2013.4

Mediastinal gray zone lymphomaに対しRituximab併用DA-EPOCH療法を施行した3症例

吉岡尚徳, 佐伯恭昌, 浅野豪, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 品川克至, 吉野正, 谷本光音

日本内科学会雑誌 102 ( Suppl. ) 187 - 187 2013.2

Contribution of the PD-1-PD-L Pathway to Chronic Graft-Versus-Host Disease

Hideaki Fujiwara, Koichiro Kobayashi, Hisakazu Nishimori, Masaaki Nishinohara, Sachiyo Okamoto, Ken-ichi Matsuoka, Eisei Kondo, Nobuharu Fujii, Katsuji Shinagawa, Mitsune Tanimoto, Yoshinobu Maeda

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19 ( 2 ) S324 - S325 2013.2

新しい全自動型血液成分分離装置Spectra Optiaを用いた末梢血幹細胞採取Cobe Spectraと比較して

藤井敬子, 淺田騰, 西森久和, 山川美和, 森繰代, 狩山由貴, 池田亮, 浅野尚美, 小郷博昭, 藤井伸治, 岩月啓氏

日本輸血細胞治療学会誌 59 ( 1 ) 91 - 91 2013.2

当院同種造血幹細胞移植症例におけるDisease risk indexの有用性の検討

浅野豪, 近藤英生, 佐伯恭昌, 長谷川詠子, 黒井大雅, 西森久和, 松岡賢市, 浅田騰, 藤井敬子, 藤井伸治, 藤井伸治, 前田嘉信, 品川克至, 谷本光音

日本造血細胞移植学会総会プログラム・抄録集 35th 2013

非血縁者間骨髄移植後再発に対してドナーリンパ球輸注療法が著効したGATA2変異を有するMonoMac症候群の1例

増成太郎, 枝廣暁, 大倉浩子, 鈴木優子, 長澤紗詠子, 木村耕介, 木口亨, 瀬崎伸夫, 石井啓太, 吉岡尚徳, 西森久和, 新谷大悟, 藤井伸治, 前田嘉信, 品川克至, 村松秀城, 小島勢二, 新谷憲治

日本造血細胞移植学会総会プログラム・抄録集 35th 2013

Erdheim-Chester病が強く疑われた下垂体機能低下症の一例

三好智子, 大塚文男, 稲垣兼一, 田中康司, 越智可奈子, 藤井一恭, 藤井伸治, 当真貴志雄, 中村絵里, 塚本尚子, 武田昌也, 三村由香里, 小倉俊郎, 景山甚郷, 槇野博史

日本内分泌学会雑誌 88 ( 3 ) 1017 - 1017 2012.12

Mediastinal gray zone lymphomaに対しRituximab併用DA-EPOCH療法を施行した3症例

佐伯恭昌, 吉岡尚徳, 淺野豪, 黒井大雅, 長谷川詠子, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 品川克至, 吉野正, 谷本光音

日本癌治療学会誌 47 ( 3 ) 2508 - 2508 2012.10

骨髄内骨髄移植はidiopathic pneumonia syndromeの発症を予防する

山筋好子, 西森久和, 杉山暖子, 小林孝一郎, 門久幸代, 近藤英生, 藤井伸治, 品川克至, 谷本光音, 前田嘉信, 金蔵拓郎

西日本皮膚科 74 ( 4 ) 455 - 456 2012.8

縦隔原発悪性リンパ腫に対しRituximab併用DA-EPOCH療法を施行した2症例

吉岡尚徳, 藤原英晃, 淺野豪, 廻勇輔, 黒井大雅, 長谷川詠子, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 品川克至, 吉野正, 谷本光音

日本リンパ網内系学会会誌 52 124 - 124 2012.5

日本輸血・細胞治療学会による細胞療法の体制に関する全国調査

藤井敬子, 西森久和, 藤井伸治, 池田亮, 浅野尚美, 小郷博昭, 岩月啓氏, 池田和眞, 田中朝志, 佐川公矯, 大戸斉, 高橋孝喜

日本輸血細胞治療学会誌 57 ( 6 ) 511 - 512 2011.12

輸血検査の検体間違いに関するインシデントの検討

浅野尚美, 池田亮, 小郷博昭, 山口麻由美, 西森久和, 藤井敬子, 藤井伸治, 池田和眞, 岩月啓氏

日本輸血細胞治療学会誌 57 ( 6 ) 507 - 507 2011.12

Prevention of Idiopathic Pneumonia Syndrome by Intra-Bone Marrow Injection of Donor Cells

Yoshiko Yamasuji, Hisakazu Nishimori, Haruko Sugiyama, Koichiro Kobayashi, Sachiyo Okamoto, Eisei Kondo, Nobuharu Fujii, Katsuji Shinagawa, Takuro Kanekura, Mitsune Tanimoto, Yoshinobu Maeda

BLOOD 118 ( 21 ) 830 - 830 2011.11

同種造血細胞移植後の閉塞性細気管支炎岡山BMTグループ3施設での経験

藤井伸治, 中瀬浩一, 朝倉昇司, 原嘉孝, 松岡賢市, 近藤英生, 前田嘉信, 名和由一郎, 角南一貴, 品川克至, 池田和眞, 原雅道, 谷本光音

臨床血液 52 ( 9 ) 1108 - 1108 2011.9

中枢神経系悪性リンパ腫に対する自己末梢血幹細胞移植併用大量化学療法

近藤英生, 市川智継, 前田嘉信, 黒川和彦, 青山一利, 吉田将平, 原嘉孝, 新谷大悟, 西森久和, 藤井敬子, 藤井伸治, 品川克至, 谷本光音

臨床血液 52 ( 9 ) 1127 - 1127 2011.9

同種末梢血幹細胞採取における至適タイミングの検討

藤井敬子, 西森久和, 藤井伸治, 池田和真, 谷本光音

臨床血液 52 ( 9 ) 1174 - 1174 2011.9

中枢神経系悪性リンパ腫に対する自己末梢血幹細胞移植併用大量化学療法

近藤英生, 前田嘉信, 青山一利, 吉田将平, 原嘉孝, 廻勇輔, 新谷大悟, 品川克至, 西森久和, 藤井敬子, 藤井伸治, 黒住和彦, 市川智継, 谷本光音

日本リンパ網内系学会会誌 51 98 - 98 2011.6

悪性リンパ腫に対する臍帯血移植23例の検討

西之原正昭, 藤原英晃, 廻勇輔, 吉岡尚徳, 新谷大悟, 近藤英正, 藤井伸治, 前田嘉信, 品川克至, 谷本光音

日本リンパ網内系学会会誌 51 83 - 83 2011.6

BRONCHIOLITIS OBLITERANS SYNDROME AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: ANALYSIS OF SINGLE CENTER EXPERIENCE

N. Fujii, Y. Hara, N. Nishinohara, E. Kondo, Y. Maeda, K. Shinagawa, M. Tanimoto

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 17 ( 2 ) S243 - S243 2011.2

早期から末梢血に異常細胞が出現したIVLの一例

杉山暖子, 前田嘉信, 小林孝一郎, 田淵貴大, 西森久和, 山筋好子, 松岡賢市, 藤井伸治, 品川克至, 石丸文彦, 池田和真, 谷本光音

臨床血液 47 ( 9 ) 1128 - 1128 2006.9

Diffuse large B-cell lymphoma(DLBCL)に対するCHOPとR-CHOPの多施設共同後方視的比較検討

名和由一郎, 松尾恵太郎, 角南一貴, 砥谷和人, 滝本秀隆, 西森久和, 平松靖史, 木口亨, 矢野朋文, 山根弘路, 多林孝之, 藤井総一郎, 宮田明, 竹内誠, 牧田雅典, 瀬崎伸夫, 山筋好子, 杉山暖子, 田淵貴大, 片岡到, 藤井伸治, 前田嘉信, 品川克至, 石丸文彦, 池田和真, 原雅道, 谷本光音, 西日本血液腫瘍研究グループ

臨床血液 47 ( 9 ) 1005 - 1005 2006.9

再発・治療抵抗性非ホジキンリンパ腫に対するIDEA療法の有効性と安全性の検討

西森久和, 藤井伸治, 松尾恵太郎, 小林孝一郎, 杉山暖子, 田淵貴大, 山筋好子, 久保西四郎, 難波寛子, 松岡賢市, 片山義雄, 前田嘉信, 品川克至, 石丸文彦, 池田和真, 谷本光音

臨床血液 47 ( 9 ) 1134 - 1134 2006.9

発熱で発症し診断に苦慮したIVLの一例

杉山暖子, 前田嘉信, 田淵貴大, 西森久和, 山筋好子, 藤井伸治, 品川克至, 石丸文彦, 池田和真, 谷本光音

日本リンパ網内系学会会誌 46 76 - 76 2006.6

進行期低悪性度リンパ腫に対する骨髄非破壊的同種造血幹細胞移植

久保西四郎, 田淵貴大, 山筋好子, 杉山暖子, 西森久和, 藤井伸治, 前田嘉信, 品川克至, 石丸文彦, 池田和真, 谷本光音

日本リンパ網内系学会会誌 46 100 - 100 2006.6

Hodgkin/Reed-Sternberg様細胞を散在性に認めるLymphoplasmacytic lymphomaの一例

小山幹子, 品川克至, 青山一利, 増成太郎, 近藤英生, 藤井伸治, 豊嶋崇徳, 石丸文彦, 池田和真, 谷本光音, 佐藤由美子, 市村浩一, 吉野正

日本リンパ網内系学会会誌 44 129 - 129 2004.6

8.自己末梢血幹細胞至適採取時期決定における末梢血CIC countの有効性に関する検討(一般演題)(日本アフェレシス学会第22回関西地方会抄録)

吉田親正, 池田和真, 小塚輝彦, 久保西四郎, 小出典男, 豊嶋崇徳, 藤井伸治, 品川克至, 石丸文彦, 谷本光音

日本アフェレシス学会雑誌 23 ( 2 ) 207 - 207 2004

Peripheral blood circulating immature cell counts predict CD34+cell yields in granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cell collection in healthy donors.

K Ikeda, T Kozuka, T Teshima, C Yoshida, S Kubonishi, K Sunami, K Matsuo, K Masuda, N Fujii, K Takenaka, K Shinagawa, F Ishimaru, N Koide, M Harada, M Tanimoto

BLOOD 102 ( 11 ) 414B - 414B 2003.11

Multilineage involvement in hypereosinophilic syndrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8

N Fujii, K Ikeda, N Takahashi, K Kojima, Y Kobayashi, A Ashiba, K Takenaka, S Fukuda, K Shinagawa, F Ishimaru, K Niiya, Miura, I, M Tanimoto, M Harada

BRITISH JOURNAL OF HAEMATOLOGY 119 ( 3 ) 716 - 719 2002.12

Language：English Publisher：BLACKWELL PUBLISHING LTD

We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.

DOI： 10.1046/j.1365-2141.2002.03922.x

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Allografting of peripheral blood stem cell mobilized from a donor developing herpes zoster virus infection [5]

Toshi Imai, Yoshinobu Maeda, Nobuharu Fujii, Katsuto Takenaka, Katsuji Shinagawa, Fumihito Ishimaru, Kazuma Ikeda, Kenji Niiya, Mine Harada

American Journal of Hematology 71 ( 2 ) 140 - 141 2002.10

Differentiation of monoblastic cell line UG3 into leukemic dendritic cells

N Fujii, T Ikeda, K Ikeda, A Hiraki, K Kawakami, K Masuda, Y Maeda, K Hatake, K Motoyoshi, M Harada, M Tanimoto

INTERNATIONAL JOURNAL OF ONCOLOGY 21 ( 3 ) 617 - 620 2002.9

Language：English Publisher：PROFESSOR D A SPANDIDOS

Dendritic cells (DCs) are known to be generated from leukemic clone from patients with acute and chronic leukemia when cultured in the presence of combination of granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha) and interleukin-4. However, there have been few reports that showed DCs could be effectively differentiated from human leukemia cell lines. In this study, we have shown that a human monoblastic cell line, UG3, was inducible to differentiate into DCs in the presence of GM-CSF and TNF-alpha along monocyte-macrophage lineage. These DCs, consistently displayed dendritic morphology, phenotypes and allogeneic T-cell stimulating capacity. UG3 cells thus may represent a suitable model to further elucidate characteristics of DC differentiation.

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Successful Treatment of Progressive NK Cell Lymphoma with Allogeneic Peripheral Stem Cell Transplantation Followed by Early Cyclosporine Tapering and Donor Leukocyte Infusions

MAKITA Masanori, MAEDA Yoshinobu, TAKENAKA Katsuto, SHINAGAWA Katsuji, SUNAMI Kazutaka, HIRAMATSU Yasushi, FUJII Nobuharu, ISHIMARU Fumihiko, IKEDA Kazuma, NIIYA Kenji, YOSHINO Tadashi, HARADA Mine

Int J Hematol 76 ( 1 ) 94 - 97 2002.7

Expression of minor histocompatibility antigen, HA-1, in solid tumor cells

N Fujii, A Hiraki, K Ikeda, Y Ohmura, Nozaki, I, K Shinagawa, F Ishimaru, K Kiura, N Shimizu, M Tanimoto, M Harada

TRANSPLANTATION 73 ( 7 ) 1137 - 1141 2002.4

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

Background. Minor histocompatibility antigen (mHag) induces and mounts graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Among several mHags, HA-1 is one that acts alone and is the most studied. It is suggested that HA-1 may be one of the immunodominant antigens inducing not only graft-versus-host disease but also graft-versus-malignancy effects. There are some reports that mHag HA-1-specific cytotoxic T lymphocytes generated from an HA-1-negative donor can lyse HA-1-positive leukemic cells. However, the tissue distribution of HA-1 has been described as restricted to the cells of the hematopoietic lineage.
Methods. We examined the HA-1 expression in peripheral blood mononuclear cells (PBMNC), leukemia/lymphoma cell lines, solid tumor cell lines, and paired samples of tumor and normal tissues from individual cancer patients by quantitative reverse-transcription polymerase chain reaction.
Results. We found that mRNA of HA-1 is expressed in all leukemia/lymphoma cell lines and PBMNC. Most of the leukemia/lymphoma cell lines have the same levels of HA-1 expression as a leukemia/lymphoma cell line, Raji. The expression levels of human PBMNC were 14- to 19-fold higher than those of Raji. Among 32 solid tumor cell lines, 7 showed >50% expression levels compared with Raji.
Conclusions. HA-1 expression in the mRNA level is higher in cells of hematopoietic origin, but this tissue distribution is not strictly restricted. Some solid tumor cells and tissues express HA-1 gene equal to hematopoietic cells.

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Differentiation of monoblastic cell line UG3 into leukemic dendritic cells.

Fujii N, Ikeda T, Ikeda K, Hiraki A, Kawakami K, Masuda K, Maeda Y, Hatake K, Motoyoshi K, Harada M, Tanimoto M.

Int J Oncol. 21 ( 3 ) 617 2002

Expression of minor histocompatibility antigen, HA-1, in solid tumor cells. International journal

Nobuharu Fujii, Akio Hiraki, Kazuma Ikeda, Yasushi Ohmura, Isao Nozaki, Katsuji Shinagawa, Fumihiko Ishimaru, Katsuyuki Kiura, Nobuyoshi Shimizu, Mitsune Tanimoto, Mine Harada

Transplantation 73 ( 7 ) 1137 - 41 2002

Language：English

BACKGROUND: Minor histocompatibility antigen (mHag) induces and mounts graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Among several mHags, HA-1 is one that acts alone and is the most studied. It is suggested that HA-1 may be one of the immunodominant antigens inducing not only graft-versus-host disease but also graft-versus-malignancy effects. There are some reports that mHag HA-1-specific cytotoxic T lymphocytes generated from an HA-1-negative donor can lyse HA-1-positive leukemic cells. However, the tissue distribution of HA-1 has been described as restricted to the cells of the hematopoietic lineage. METHODS: We examined the HA-1 expression in peripheral blood mononuclear cells (PBMNC), leukemia/lymphoma cell lines, solid tumor cell lines, and paired samples of tumor and normal tissues from individual cancer patients by quantitative reverse-transcription polymerase chain reaction. RESULTS: We found that mRNA of HA-1 is expressed in all leukemia/lymphoma cell lines and PBMNC. Most of the leukemia/lymphoma cell lines have the same levels of HA-1 expression as a leukemia/lymphoma cell line, Raji. The expression levels of human PBMNC were 14- to 19-fold higher than those of Raji. Among 32 solid tumor cell lines, 7 showed >50% expression levels compared with Raji. CONCLUSIONS: HA-1 expression in the mRNA level is higher in cells of hematopoietic origin, but this tissue distribution is not strictly restricted. Some solid tumor cells and tissues express HA-1 gene equal to hematopoietic cells.

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Multilineage involvement on hypereosinophilic symdrome terminating in granulocytic sarcoma and leukaemic transformation with trisomy 8.

Br J Haematol. 119 ( 3 ) 716 2002

GM-CSF and TNF-alpha induce monoblastic line UG3 to differentiate into dendritic cells.

K Masuda, N Fujii, K Ikeda, A Hiraki, T Ikeda, K Kawakami, M Harada, M Tanimoto

BLOOD 98 ( 11 ) 228A - 229A 2001.11

High-dose chemotherapy with hematopoietic stem cell transplantation is effective for nasal and nasal-type CD56(+) natural killer cell lymphomas

K Takenaka, K Shinagawa, Y Maeda, M Makita, T Kozuka, A Ashiba, K Yamamoto, N Fujii, Y Nawa, Y Hiramatsu, K Sunami, F Ishimaru, T Yoshimo, K Kiura, M Harada

LEUKEMIA & LYMPHOMA 42 ( 6 ) 1297 - 1303 2001.11

Language：English Publisher：TAYLOR & FRANCIS LTD

CD56(+) natural killer (NK) cell lymphomas occur frequently in the nasal and nasopharyngeal regions and carry a poor prognosis. We have studied seven cases with NK-cell lymphomas. These lymphomas showed the following immunophenotype: CD56(+), CD2(+), sCD3(-) and Epstein-Barr virus-encoded small RNAs (EBERs)(+). Six patients had localized (stage I or II) disease involving the nasopharyngeal region, while one had stage III disease. One patient with stage I disease achieved a complete remission (CR) after treatment with involved-field irradiation, but subsequently relapsed and died. The remaining six patients received combination chemotherapy as primary treatment: five patients with localized stage I or II disease and one patient with advanced stage III disease. Responses to initial chemotherapy were generally poor. These six patients received a variety of salvage chemotherapy regimens, but never achieved a CR. Subsequently, four of six patients showed a highly aggressive clinical course and died of disseminated disease within 1 year from the diagnosis. Three of six patients received high-dose chemotherapy supported by syngeneic, autologous or allogeneic peripheral blood stem cell transplantation. Two of the three transplant patients achieved a CR and are now surviving in continuous CR. Our clinical experience suggests that myeloablative high-dose chemotherapy and bone marrow rescue by hematopoietic stem cell transplantation may be an effective salvage treatment modality for refractory NK-cell lymphomas and could be considered as a part of the initial therapy for these patients.

DOI： 10.1080/10428190127500

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Hepatic graft-versus-host disease presenting as an acute hepatitis after allogeneic peripheral blood stem cell transplantation

N Fujii, K Takenaka, K Shinagawa, K Ikeda, Y Maeda, K Sunami, Y Hiramatsu, K Matsuo, F Ishimaru, K Niiya, T Yoshino, N Hirabayashi, M Harada

BONE MARROW TRANSPLANTATION 27 ( 9 ) 1007 - 1010 2001.5

Language：English Publisher：NATURE PUBLISHING GROUP

Hepatic graft-versus-host disease (GVHD) generally presents as cholestatic jaundice, and increased serum alkaline phosphatase (ALP) is followed by hyperbilirubinemia and clinical jaundice. Currently accepted standards for evaluating the clinical severity of GVHD are based not on serum aminotransferase levels but on the serum bilirubin level. We describe a 17-year-old Japanese female who had increased aminotransferases without cholestasis on day 23 after allogeneic peripheral blood stem cell transplantation (allo-PBSCT), Liver biopsy revealed lymphocytic infiltration of the portal tracts and pericentral necrosis of the lobuli, The limiting plates were not clearly defined due to cellular infiltrates. There was periductal lymphocytic infiltration and vacuolization of the biliary epithelial cells with exocytosis, compatible with GVHD of cholangiohepatitic type. These findings indicate that acute hepatic GVHD may present as acute hepatitis and this should be included in the differential diagnosis for patients with increased aminotransferases after allogeneic stem cell transplantation.

DOI： 10.1038/sj.bmt.1702997

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Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma

K Matsuo, K Takenaka, H Shimomura, N Fujii, K Shinagawa, K Kiura, M Harada

LEUKEMIA & LYMPHOMA 41 ( 1-2 ) 191 - 195 2001.3

Language：English Publisher：HARWOOD ACAD PUBL GMBH

We report a chronic hepatitis B virus (HBV) carrier with non-Hodgkin lymphoma (NHL) who developed HBV hepatitis following conventional dose chemotherapy and was successfully treated with lamivudine and glycyrrhizin. A 55 year-old male patient with primary testicular NHL (diffuse large B-cell type) relapsed. During the salvage chemotherapy, the patient showed elevated serum levels of transaminase and HBV-DNA due to HBV reactivation. Treatment with lamivudine. an antiviral nucleoside analog, was started at a dose of 100mg/day. Shortly after the treatment the HBV-DNA level was suppressed, and sustained elevation of transaminase levels were normalized after additional treatment with glycyrrhizin. This experience suggests that lamivudine combined with glycyrrhizin may be effective:e for controlling HBV replication and treating chemotherapy-induced HBV hepatitis in chronic HBV carriers with NHL.

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Hepatic graft-versus-host disease presenting as acute hepatitis after allogeneic peripheral blood stem cell transplantation

FUJII N

Bone Marrow Transplant 27 ( 9 ) 1007 - 1010 2001

G-CSF投与健常人ドナーからの末梢血幹細胞採取の経験(一般演題,日本アフェレシス学会第19回関西地方会抄録)

今井利, 小塚輝彦, 山本和彦, 藤井伸治, 前田嘉信, 中克斗, 品川克至, 池田和真, 原田実根, 角南一貴

日本アフェレシス学会雑誌 20 ( 1 ) 118 - 118 2001

Successful engraftment of allogeneic peripheral blood stem cell transplant after nonmyeloablative preparative regimen with cytarabine and cyclophosphamide: Report of 2 cases

N Fujii, Y Maeda, K Takenaka, K Shinagawa, T Imai, T Kozuka, K Ikeda, K Sunami, Y Hiramatsu, F Ishimaru, K Niiya, M Harada

INTERNATIONAL JOURNAL OF HEMATOLOGY 72 ( 4 ) 499 - 503 2000.12

Language：English Publisher：CARDEN JENNINGS PUBL CO LTD

We report our experience with allogeneic peripheral blood stem cell transplantation (allo-PBSCT) following a nonmyeloablative conditioning regimen consisting of cytarabine (8 g/m(2)) and cyclophosphamide (120 mg/kg) in the treatment of 2 patients aged 50 and 55 years with refractory chronic myelomonocytic leukemia and chronic myeloid leukemia in accelerated phase, respectively. Our nonmyeloablative regimen was well tolerated by older patients at high risk of regimen-related toxicity by the conventional conditioning regimen but was immunosuppressive enough to achieve mixed chimerism. After allo-PBSCT, we monitored chimerism in these patients by fluorescence in situ hybridization using X- and Y-specific probes and polymerase chain reaction-based analysis of a variable number of tandem repeats. We found that full chimerism and graft-versus-leukemia (GVL) effects could be induced in these patients by donor lymphocyte infusions and withdrawal of post transplantation immunosuppressive therapy. Our observations suggest that a nonmyeloablative conditioning regimen can establish mixed chimerism and that donor lymphocyte infusion may induce GVL effects in older patients at high risk of regimen-related toxicity. Int J Hematol. 2000;72:499-503. (C)2000 The Japanese Society of Hematology.

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Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection

N Fujii, K Takenaka, A Hiraki, Y Maeda, K Ikeda, K Shinagawa, A Ashiba, M Munemasa, K Sunami, Y Hiramatsu, F Ishimaru, K Niiya, T Yoshino, M Harada

BONE MARROW TRANSPLANTATION 26 ( 7 ) 805 - 808 2000.10

Language：English Publisher：NATURE PUBLISHING GROUP

The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT), On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

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Allogeneic peripheral blood stem cell transplantation for the treatment of chronic active Epstein-Barr virus infection

N Fujii, K Takenaka, A Hiraki, Y Maeda, K Ikeda, K Shinagawa, A Ashiba, M Munemasa, K Sunami, Y Hiramatsu, F Ishimaru, K Niiya, T Yoshino, M Harada

BONE MARROW TRANSPLANTATION 26 ( 7 ) 805 - 808 2000.10

Language：English Publisher：NATURE PUBLISHING GROUP

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Allogeneic Peripheral Blood Stem Cell Transplantation in 23 Adult Patients With Hematologic Malignancies: A Single-Center Experience

TAKENAKA Katsuto, SHINAGAWA Katsuji, SUNAMI Kazutaka, FUJII Nobuharu, HIRAMATSU Yasushi, MAEDA Yoshinobu, NAWA Yuichiro, KATAYAMA Yoshio, TESHIMA Takanori, ISHIMARU Fumihiko, KIURA Katsuyuki, IKEDA Kazuma, HARADA Mine

Int J Hematol 72 ( 3 ) 362 - 370 2000.10

A CASE OF ANAPHYLAXIS AFTER PLATELET CONCENTRATE TRANSFUSION WITH ANTI-IGAM (1) AND C9 ANTIBODIES

46 ( 3 ) 324 - 329 2000

Successful engraftment of allogeneic peripheral blood stem cell transplant after nonmyeloablative preparative regimen

Int J Hematol 72 ( 4 ) 499 2000

Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia

H Nakayama, F Ishimaru, N Avitahl, N Sezaki, N Fujii, K Nakase, Y Ninomiya, A Harashima, J Minowada, J Tsuchiyama, K Imajoh, T Tsubota, S Fukuda, T Sezaki, K Kojima, M Hara, H Takimoto, S Yorimitsu, Takahashi, I, A Miyata, S Taniguchi, Y Tokunaga, H Gondo, Y Niho, S Nakao, T Kyo, H Dohy, N Kamada, M Harada

CANCER RESEARCH 59 ( 16 ) 3931 - 3934 1999.8

Language：English Publisher：AMER ASSOC CANCER RESEARCH

Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor gene in mice. This prompted us to investigate whether mutations in Ikaros play a role in human hematological malignancies. Reverse transcription-PCR was used to determine the relative expression Levels of Ikaros isoforms in a panel of human leukemia/lymphoma cell lines and human bone marrow samples from patients with hematological malignancies. Among the cell lines examined, only BV-173, which was derived from a chronic myelogenous Leukemia (CML) patient in lymphoid blast crisis, overexpressed the dominant-negative isoform, Ik-6. In 9 of 17 samples of patients in blast crisis of CML, Ikaros activity had been reduced either by drastically reducing mRNA expression (4 of 17) or by overexpressing the dominant-negative isoform Ik-6 (5 of 17). Significantly, expression of Ikaros isoforms seemed normal in chronic phase CML patients and patients with other hematological malignancies. In some cases, overexpression of the dominant-negative Ik-6 protein was confirmed by Western blot analysis, and Southern blot analysis indicated that decreases in Ikaros activity correlated with a mutation in the Ikaros Locus. In summary, these findings suggest that a reduction of Ikaros activity may be an important step in the development of blast crisis in CML and provide further evidence that mutations that alter Ikaros expression may contribute to human hematological malignancies.

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Molecular characterization of total kininogen deficiency in Japanese patients

F Ishimaru, H Dansako, K Nakase, N Fujii, N Sezaki, H Nakayama, N Fujii, Y Komiyama, K Iijima, K Takenaka, T Teshima, K Shinagawa, K Ikeda, K Niiya, M Harada

INTERNATIONAL JOURNAL OF HEMATOLOGY 69 ( 2 ) 126 - 128 1999.2

Language：English Publisher：CARDEN JENNINGS PUBL CO LTD

Kininogens are multifunctional plasma glycoproteins. There are two forms of human kininogen: low molecular weight kininogen (LK) and high molecular weight kininogen (HK). Both are derived from the same gene by alternative splicing. Same patients with kininogen deficiency have been reported to be deficient only in HK while others are deficient in both HK and LK (total kininogen deficiency). We analyzed three Japanese patients with total kininogen deficiency by the Csp45I digestion study of exon 5 as previously reported in Williams trait and found that two had the same point mutation of C to T at base 22 of exon 5, resulting in a transition of CGA (Arg) codon to TGA (Stop) codon. This is the first report of molecular characterization of total kininogen deficiency in the Japanese population. (C) 1999 The Japanese Society of Hematology.

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