研究者詳細 - 藤井　伸治

論文 - 藤井　伸治

分割表示 165 件中 101 - 120 件目／全件表示 >>

Neurolymphomatosis in the Cauda Equina Diagnosed by an Open Biopsy.

Sasaki R, Ohta Y, Yamada Y, Tadokoro K, Takahashi Y, Sato K, Shang J, Takemoto M, Hishikawa N, Yamashita T, Yasuhara T, Date I, Ikegawa S, Fujii N, Abe K

Intern Med 57 ( 23 ) 3463 - 3465 2018年

健常人ドナーにおけるクエン酸中毒 CMNCモードとMNCモードで違いがあるのか

藤井敬子, 清家圭介, 三道康永, 中村真, 高木尚江, 閘結稀, 池田亮, 浅野尚美, 小郷博昭, 藤井伸治, 大塚文男

日本輸血細胞治療学会誌 63 ( 6 ) 823 - 823 2017年12月

A nationwide survey of hypoplastic myelodysplastic syndrome (a multicenter retrospective study) 査読

Kobayashi T, Nannya Y, Ichikawa M, Oritani K, Kanakura Y, Tomita A, Kiyoi H, Kobune M, Kato J, Kawabata H, Shindo M, Torimoto Y, Yonemura Y, Hanaoka N, Nakakuma H, Hasegawa D, Manabe A, Fujishima N, Fujii N, Tanimoto M, Morita Y, Matsuda A, Fujieda A, Katayama N, Ohashi H, Nagai H, Terada Y, Hino M, Sato K, Obara N, Chiba S, Usuki K, Ohta M, Imataki O, Uemura M, Takaku T, Komatsu N, Kitanaka A, Shimoda K, Watanabe K, Tohyama K, Takaori-Kondo A, Harigae H, Arai S, Miyazaki Y, Ozawa K, Kurokawa M

Am J Hematol. 2017年9月

Successful use of etoposide for pyoderma gangrenosum associated with myelodysplastic syndrome and trisomy 8: cytokine profiles during treatment 査読

Dan Fujiwara, Toshihisa Hamada, Osamu Yamasaki, Yasuhisa Sando, Kyosuke Saeki, Nobuharu Fujii, Yoshio Kawakami, Keiji Iwatsuki

EUROPEAN JOURNAL OF DERMATOLOGY 27 ( 5 ) 525 - 527 2017年9月

Predictors of vasovagal reactions during preoperative autologous blood donation 査読

Hisakazu Nishimori*,Nobuharu Fujii*,Keiko Fujii*,Tohru Ikeda,Naomi Asano,Hiroaki Ogo,Miwa Yamakawa,Naoe Takagi,Fumio Otsuka*,Kazuma Ikeda

International Journal of Hematology, Nippon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, Acta Haematologica Japonica 105 ( 6 ) 812 - 818 2017年6月

Graft-versus-leukemia effect with a WT1-specific T-cell response induced by azacitidine and donor lymphocyte infusions after allogeneic hematopoietic stem cell transplantation 査読国際誌

Tatsunori Ishikawa,Nobuharu Fujii*,Masahide Imada,Michinori Aoe,Yusuke Meguri*,Tomoko Inomata,Hiromi Nakashima,Keiko Fujii*,Shohei Yoshida,Hisakazu Nishimori*,Ken Ichi Matsuoka *,Eisei Kondo*,Yoshinobu Maeda*,Mitsune Tanimoto*

Cytotherapy 19 ( 4 ) 514 - 520 2017年4月

Phase II study of intrabone single unit cord blood transplantation for hematological malignancies 査読

Makoto Murata,Yoshinobu Maeda*,Masayoshi Masuko,Yasushi Onishi,Tomoyuki Endo,Seitaro Terakura,Yuichi Ishikawa,Chisako Iriyama,Yoko Ushijima,Tatsunori Goto,Nobuharu Fujii*,Mitsune Tanimoto,Hironori Kobayashi,Yasuhiko Shibasaki,Noriko Fukuhara,Yoshihiro Inamoto,Ritsuro Suzuki,Yoshihisa Kodera,Tadashi Matsushita,Hitoshi Kiyoi,Tomoki Naoe,Tetsuya Nishida

Cancer Science, Japanese Journal of Cancer Research, Gann, The Japanese Journal of Cancer Research 202 - 16 2017年1月

Ruxolitinib treatment for GvHD in patients with myelofibrosis 査読

Y. Mori ,K. Ikeda,T. Inomata ,G. Yoshimoto,N. Fujii*,H. Ago,T. Teshima

Bone Marrow Transplantation 51 ( 12 ) 1584 - 1587 2016年12月

Treatment of thrombotic microangiopathy after hematopoietic stem cell transplantation with recombinant human soluble thrombomodulin. 査読国際誌

Transfusion 56 ( 4 ) 886 - 92 2016年4月

Vigorous inflammatory responses in noninfectious pulmonary complication induced by donor lymphocyte infusion 査読国際誌

Miyuki Nishie,Nobuharu Fujii*,Yusuke Mimura,Takeru Asano*,Yuka Mimura-Kimura,Keisuke Aoe,Michinori Aoe,Hiromi Nakashima,Hideaki Fujiwara,Hisakazu Nishimori*,Ken Ichi Matsuoka*,Eisei Kondo*,Yoshinobu Maeda*,Mitsune Tanimoto*

Transfusion 56 ( 1 ) 231 - 236 2016年1月

Magnifying Endoscopic Observation of Duodenal Involvement of Follicular Lymphoma before and after Chemotherapy 査読

(Iwamuro M, Okada H, Takata K,) Fujii N, (Kawano S, Kawahara Y, Yoshino T and Yamamoto K)

Intern Med 54 ( 14 ) 1741 - 1745 2015年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japanese Society of Internal Medicine

A 60-year-old Japanese man was diagnosed with systemic follicular lymphoma with duodenal, jejunal, and ileal involvement. The duodenal lesion showed typical endoscopic features with multiple whitish granules. Chemotherapy with bendamustine and rituximab was administered, and complete remission was confirmed by CT scanning and positron emission tomography scanning. Although the duodenal granular lesions did not completely disappear, magnifying observation for the remaining lesions showed no evidence of residual lymphoma. Complete remission was pathologically confirmed by biopsy examinations. This case suggests the usefulness of magnifying observation in evaluating the effects of treatment for duodenal follicular lymphoma lesions.<br>

DOI： 10.2169/internalmedicine.54.4390

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その他リンク： http://search.jamas.or.jp/link/ui/2016310064

Anti-IL-12/23 p40 Antibody Attenuates Experimental Chronic Graft-versus-Host Disease via Suppression of IFN-g/IL-17 Producing Cells. 査読国際誌

Okamoto S, Fujiwara H, Nishimori H, Matsuoka K, Fujii N, Kondo E, (Tanaka T, Yoshimura A), Tanimoto M, Maeda Y.

J Immunol 194 ( 3 ) 1357 - 1363 2015年2月

多発転移に伴い血小板減少を合併した頭部血管肉腫の1例査読

(瀧口徹也, 山崎修, 牧野麻貴,) 佐伯恭昌, 藤井伸治, (濱田和俊, 岩月啓氏)

Skin Cancer 29 ( 3 ) 323 - 327 2015年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本皮膚悪性腫瘍学会

35歳、男性。2012年3月より前頭部に紅斑が出現し、その後結節病変が徐々に隆起し周囲に紫斑が拡大した。近医での生検にて血管肉腫と診断され、5月に当院紹介受診。前頭部に暗紫色の嚢腫状結節を認め、周囲に出血斑を伴っていた。6月より電子線照射とweeklyパクリタキセル療法4コース、monthlyパクリタキセル療法3コース施行。2013年1月に血小板14000/μLと急激な減少のため、入院した。抗血小板抗体陰性、PA-IgG陽性、ヘリコバクター・ピロリIgG陽性。DICの所見は認めなかった。骨髄生検では巨核球十分、腫瘍の浸潤も認めなかった。ITPが疑われ、血小板輸血を施行し、免疫グロブリン大量療法とプレドニゾロン(PSL)を開始した。入院後のCT、MRIで両側耳下腺、胸椎、右寛骨、肺転移を認め、緩和目的に骨転移に対してX線治療した。その後、血小板は上昇したためPSLを漸減し、3月よりweeklyドセタキセル療法を開始した。しかし転移は徐々に進行し、血小板は再度減少した。10月肺転移による呼吸不全のため永眠された。臨床経過からは血小板減少は転移の進行による腫瘍内での血小板消費と考えた。(著者抄録)

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J02197&link_issn=&doc_id=20150316140017&doc_link_id=10.5227%2Fskincancer.29.323&url=https%3A%2F%2Fdoi.org%2F10.5227%2Fskincancer.29.323&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Primary Duodenal Follicular Lymphoma Treated With Rituximab Monotherapy and Followed-up for 15 Years 査読

Seki A, Iwamuro M, Yoshioka M, Fujii N, Okada H, Nose S, Takata K, Yoshino T, Yamamoto K

Acta Med Okayama 69 ( 5 ) 2015年1月

With regard to our manuscripts on the commercial saliva substitute, Oralbalance(R)--its formula has been changed 査読国際誌

(Sugiura Y., Soga Y., Tanimoto I., Kokeguchi S., Morishige-Nishide S., Itami-Kono K., Takahashi K.), Fujii N., Ishimaru F., Tanimoto M., (Yamabe K., Tsutani S., Nishimura F., Takashiba S)

Support Care Cancer 22 ( 12 ) 3121 - 3122 2014年12月

PD-1 pathway in host tissues ameliorates Th17/Th1 mediated experimental chronic graft-versus-host disease 査読

Fujiwara H, Maeda Y, Kobayashi K, Nishimori H, Matsuoka K, Fujii N, Kondo E, (Tanaka T, Chen L, Azuma M, Yagita H), Tanimoto M.

J Immunol 193 ( 5 ) 2565 - 2573 2014年9月

Programmed death-1 pathway in host tissues ameliorates Th17/Th1-mediated experimental chronic graft-versus-host disease 査読

Hideaki Fujiwara, Yoshinobu Maeda, Koichiro Kobayashi, Hisakazu Nishimori, Ken-Ichi Matsuoka, Nobuharu Fujii, Eisei Kondo, Takehiro Tanaka, Lieping Chen, Miyuki Azuma, Hideo Yagita, Mitsune Tanimoto

Journal of Immunology 193 ( 5 ) 2565 - 2573 2014年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Association of Immunologists

Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity after allogeneic hematopoietic cell transplantation, but its pathogenesis remains unclear. We investigated the role of the programmed death-1 (PD-1) pathway in chronic GVHD using a well-defined mouse model of B10.D2 (H-2d) donor to BALB/c (H-2d) recipients. PD-1 expression on allogeneic donor T cells was upregulated continuously in chronic GVHD development, whereas PD-L1 expression in host tissues was transiently upregulated and declined to basal levels in the late posttransplant period. Blockade of the PD-1 pathway by anti-PD-1, anti-PDL1, or anti-PD-L2 mAbs exacerbated clinical and pathologic chronic GVHD. Chimeric mice revealed that PD-L1 expression in host tissues suppressed expansion of IL-17+IFN-γ+T cells, and that PD-L1 expression on hematopoietic cells plays a role in the development of regulatory T cells only during the early transplantation period but does not affect the severity of chronic GVHD. Administration of the synthetic retinoid Am80 overcame the IL-17+IFN-γ+T cell expansion caused by PD-L1 deficiency, resulting in reduced chronic GVHD damage in PD-L1-/-recipients. Stimulation of the PD-1 pathway also alleviated chronic GVHD. These results suggest that the PD-1 pathway contributes to the suppression of Th17/Th1-mediated chronic GVHD and may represent a new target for the prevention or treatment of chronic GVHD.Copyright

DOI： 10.4049/jimmunol.1400954

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非血縁者間同種骨髄移植後にドナー由来の抗Jraが検出された慢性骨髄性白血病の1例査読

池田亮、小郷博昭、浅野尚美、浅田騰、藤井敬子、藤井伸治

Japanese Journal of Transfusion and Cell Therapy 60 ( 3 ) 483 - 487 2014年7月

Low-grade B-cell lymphoma presenting primarily in the bone marrow. 査読

(Iwatani K, Takata K, Sato Y, Miyata-Takata T, Iwaki N, Cui W, Sawada-Kitamura S, Sonobe H, Tamura M, Saito K, Miyatani K, Yamasaki R, Yamadori I), Fujii N, (Terasaki Y),?Maeda Y,?Tanimoto M, (Nakamura N, Yoshino T).

Hum Pathol 45 ( 7 ) 1379 - 1387 2014年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with lymphoplasmacytic lymphoma (LPL), 3 with chronic lymphocytic leukemia/small lymphocytic lymphoma, 2 with follicular lymphoma (FL), and 4 with low-grade B-cell lymphoma not otherwise specified (LGBCL-NOS). The median age was 69.5 years (range, 42-89 years), and a slight male predominance was noted (9 men and 5 women, 1.8: 1). Immunohistochemically, all cases were positive for CD20. One case was positive for CD138. Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization. The myeloid differentiation primary response gene (88) leucine to proline mutation was observed in 3 of 5 LPL, 1 of 2 FL, and 2 of 4 LGBCL-NOS patients. Paraproteinemia was observed in 10 patients; IgM and IgG paraproteinemia were observed in 6 and 3 patients, respectively. In this patient series, 3 patients had died at a median follow-up of 36.5 months; the cause of death of 1 LPL patient was malignant lymphoma itself. Thus, low-grade B-cell lymphoma presenting primarily in the bone marrow has various subtypes, and approximately one-third of the patients had LGBCL-NOS. The immunophenotypic features and myeloid differentiation primary response gene (88) leucine to proline mutation data of LGBCL-NOS suggested that some cases present with characteristics similar to those of LPL or marginal zone lymphoma.

DOI： 10.1016/j.humpath.2014.02.010

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Primary cutaneous γδT-cell lymphomaに対し、臍帯血移植を施行した1例査読

佐伯恭昌, 石川立則, 谷勝真, 山本宜和, 塩手康弘, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 品川克至, 谷本光音

臨床血液 55 ( 5 ) 587 - 587 2014年5月

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