2021/11/01 更新

写真a

イガワ タクロウ
井川 卓朗
IGAWA Takuro
所属
医歯薬学域 助教
職名
助教
外部リンク

学位

  • 博士(医学) ( 2016年3月   岡山大学大学院 )

研究キーワード

  • 人体病理学

研究分野

  • ライフサイエンス / 人体病理学

学歴

  • 岡山大学大学院   医歯薬学総合研究科  

    - 2016年3月

      詳細を見る

  • 岡山大学   Medical School   Faculty of Medicine

    - 2013年3月

      詳細を見る

経歴

  • 岡山大学大学院医歯薬学総合研究科   病理学(腫瘍病理)   助教

    2017年4月 - 現在

      詳細を見る

所属学協会

  • 日本病理学会

    2015年4月 - 現在

      詳細を見る

 

論文

  • 形質細胞型特発性多中心性キャッスルマン病およびIgG4関連疾患における肺病変の臨床組織学的検討

    西村 碧フィリーズ, 井川 卓朗, 西村 義人, 吉野 正, 佐藤 康晴

    日本リンパ網内系学会会誌   61   101 - 101   2021年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • Invasion of small cell lung cancer into the limbic system from leptomeningeal metastases. 国際誌

    Hisao Higo, Takuro Igawa, Katsuhiro Matsuoka, Hiromichi Kawaji, Noriyuki Suzaki, Takuya Nagata, Masako Nagayama, Masaomi Marukawa

    Respiratory medicine case reports   33   101417 - 101417   2021年

     詳細を見る

    記述言語:英語  

    The diagnosis of leptomeningeal metastases is sometimes difficult when the cytology of cerebrospinal fluid is negative. We report a rare case of leptomeningeal metastases that required differentiation from paraneoplastic limbic encephalitis. A 67-year-old man with extensive-stage small cell lung cancer was admitted for a sudden decrease in the level of consciousness. He suffered memory disturbances that began the day before admission. Diffusion-weighted and fluid-attenuated inversion recovery images of brain magnetic resonance imaging (MRI) showed bilateral symmetric areas of hyperintensity in the hippocampus, amygdala, insular cortex, and medial temporal lobe; contrast enhancement was positive. Cytology of the cerebrospinal fluid (CSF) was negative. Anti-N-methyl-d-aspartate receptor antibody and herpes simplex virus DNA were not detected in the CSF. Paraneoplastic Limbic encephalitis was suspected due to his symptoms and brain MRI scan. The patient developed generalized seizures after admission. High-dose methylprednisolone and intravenous immune globulin were administered, but his condition did not improve. Uncontrollable seizures persisted and he died in the hospital at day 13. Autopsy revealed leptomeningeal metastasis and invasion of cancer cells into the limbic system. Contrast-enhanced MRI should be performed even if limbic encephalitis is suspected, and leptomeningeal metastases should be suspected if the lesions are enhanced.

    DOI: 10.1016/j.rmcr.2021.101417

    PubMed

    researchmap

  • Pulmonary Manifestations of Plasma Cell Type Idiopathic Multicentric Castleman Disease: A Clinicopathological Study in Comparison with IgG4-Related Disease. 国際誌

    Midori Filiz Nishimura, Takuro Igawa, Yuka Gion, Sakura Tomita, Dai Inoue, Akira Izumozaki, Yoshifumi Ubara, Yoshito Nishimura, Tadashi Yoshino, Yasuharu Sato

    Journal of personalized medicine   10 ( 4 )   2020年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Plasma cell type idiopathic multicentric Castleman disease (PC-iMCD) occasionally manifests as parenchymal lung disease. This study aimed to elucidate the detailed clinicopathological features of lung lesions in PC-iMCD and compare the findings with those in immunoglobulin (Ig) G4-related disease (IgG4-RD), the most difficult differential diagnosis of PC-iMCD. We analyzed the clinicopathological findings and immunohistochemical expression patterns of interleukin-6 (IL-6) and Igs in lung specimens from 16 patients with PC-iMCD and 7 patients with IgG4-RD. Histologically, pulmonary PC-iMCD could not be differentiated from IgG4-RD based on lesion distribution patterns, the number of lymphoid follicles and obliterative vasculitis, or fibrosis types. The eosinophil count was higher in the IgG4-RD group than in the PC-iMCD group (p = 0.004). The IgG4/IgG-positive cell ratio was significantly higher in the IgG4-RD group (p < 0.001). The IgA-positive cell count and IL-6 expression intensity were higher in the PC-iMCD group than in the IgG4-RD group (p < 0.001). Based on these findings, we proposed a new diagnostic approach to differentiate lung lesions of PC-iMCD and IgG4-RD. Our approach can be utilized to stratify patients with suspected lung-dominant PC-iMCD to identify candidates for strong immunosuppressive treatment, including IL-6 blockade, at an early stage.

    DOI: 10.3390/jpm10040269

    PubMed

    researchmap

  • Deletion of BART miRNA-encoding cluster in Epstein-Barr virus DNA in classic Hodgkin lymphoma. 国際誌

    Akihiro Kawatsuki, Takuro Igawa, Tomohiro Urata, Takehiro Tanaka, Yasuharu Sato, Tadashi Yoshino

    Pathology international   70 ( 12 )   1032 - 1033   2020年12月

     詳細を見る

    記述言語:英語  

    DOI: 10.1111/pin.13022

    PubMed

    researchmap

  • Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review.

    Hiroki Kobayashi, Noboru Asada, Takuro Igawa, Masaya Abe, Yusuke Meguri, Daisuke Ennishi, Hisakazu Nishimori, Nobuharu Fujii, Ken-Ichi Matsuoka, Tadashi Yoshino, Yoshinobu Maeda

    Internal medicine (Tokyo, Japan)   59 ( 21 )   2757 - 2761   2020年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Breast involvement of Adult T-cell leukemia-lymphoma (ATLL) is extremely rare, and the data on the characteristics are limited. We herein describe a 49-year-old woman who presented with skin involvement of ATLL. Positron emission tomography/computed tomography showed bilateral breast lesions. Although the patient once achieved a complete metabolic response, a relapse of her ATLL occurred. The patient received subsequent allogeneic hematopoietic stem cell transplantation (HSCT). To our knowledge, only four cases of ATLL with breast involvement have previously been reported, and the prognoses have generally been poor. Breast lesions of ATLL have aggressive features, and intensive systemic chemotherapy and HSCT are required to improve survival.

    DOI: 10.2169/internalmedicine.5077-20

    PubMed

    researchmap

  • Luminal preloading with hydrogen-rich saline ameliorates ischemia-reperfusion injury following intestinal transplantation in rats. 国際誌

    Hirotsugu Yamamoto, Toshiyuki Aokage, Takuro Igawa, Takahiro Hirayama, Mizuki Seya, Michiko Ishikawa-Aoyama, Tsuyoshi Nojima, Atsunori Nakao, Hiromichi Naito

    Pediatric transplantation   24 ( 7 )   e13848   2020年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Prolonged intestinal cold storage causes considerable mucosal breakdown, which could bolster bacterial translocation and cause life-threatening infection for the transplant recipient. The intestine has an intraluminal compartment, which could be a target for intervention, but has not yet been fully investigated. Hydrogen gas exerts organ protection and has used been recently in several clinical and basic research studies on topics including intestinal transplantation. In this study, we aimed to investigate the cytoprotective efficacy of intraluminally administered hydrogen-rich saline on cold IR injury in intestinal transplantation. Isogeneic intestinal transplantation with 6 hours of cold ischemia was performed on Lewis rats. Hydrogen-rich saline (H2 concentration at 5 ppm) or normal saline was intraluminally introduced immediately before preservation. Graft intestine was excised 3 hours after reperfusion and analyzed. Histopathological analysis of control grafts revealed blunting of the villi and erosion. These mucosal changes were notably attenuated by intraluminal hydrogen. Intestinal mucosa damage caused by IR injury led to considerable deterioration of gut barrier function 3 h post-reperfusion. However, this decline in permeability was critically prevented by hydrogen treatment. IR-induced upregulation of proinflammatory cytokine mRNAs such as IL-6 was mitigated by hydrogen treatment. Western blot revealed that hydrogen treatment regulated loss of the transmembrane protein ZO-1. Hydrogen-rich saline intraluminally administered in the graft intestine modulated IR injury to transplanted intestine in rats. Successful abrogation of intestinal IR injury with a novel strategy using intraluminal hydrogen may be easily clinically applicable and will compellingly improve patient care after transplantation.

    DOI: 10.1111/petr.13848

    PubMed

    researchmap

  • Clinicopathological significance of CD79a expression in classic Hodgkin lymphoma.

    Akio Sakatani, Takuro Igawa, Takeshi Okatani, Megumu Fujihara, Hideki Asaoku, Yasuharu Sato, Tadashi Yoshino

    Journal of clinical and experimental hematopathology : JCEH   60 ( 3 )   78 - 86   2020年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Classic Hodgkin lymphoma (CHL) is a lymphoid neoplasia characterized by the presence of large tumor cells, referred to as Hodgkin and Reed-Sternberg (HRS) cells, originating from B-cells in an inflammatory background. As the clinical significance of B-cell markers has yet to be fully elucidated, this study aimed to clarify the clinicopathological significance of CD79a in 55 patients with CHL. They were immunohistochemically divided into two groups, comprising of 20 CD79a-positive and 35 CD79a-negative patients. There was no significant correlation between CD79a and CD20 expression (rs = 0.125, P = 0.362). CD79a-positive patients were significantly older at onset (P = 0.011). There was no significant correlation between CD79a-positivity and clinical stage (P = 0.203), mediastinal involvement (P = 0.399), extranodal involvement (P = 0.749), or laboratory findings, including serum levels of lactate dehydrogenase (P = 1) and soluble interleukin-2 receptor (P = 0.251). There were significant differences in overall survival (OS) (P = 0.005) and progression-free survival (PFS) (P = 0.007) between CD79a-positive and CD79a-negative patients (5-year OS: 64.6% and 90.5%; 5-year PFS: 44.0% and 76.6%, respectively). Five patients in whom the majority (> 80%) of HRS cells expressed CD79a consisted of 4 males and 1 female aged between 52 and 81 years; 4 of them were in a limited clinical stage. We concluded that CD79a-positive CHL may have unique clinicopathological features.

    DOI: 10.3960/jslrt.20010

    PubMed

    researchmap

  • Hemosiderin deposition in lymph nodes of patients with plasma cell-type Castleman disease.

    Yanyan Han, Takuro Igawa, Kyohei Ogino, Asami Nishikori, Yuka Gion, Tadashi Yoshino, Yasuharu Sato

    Journal of clinical and experimental hematopathology : JCEH   60 ( 1 )   1 - 6   2020年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Plasma cell-type Castleman disease (PCD) is a rare idiopathic atypical lymphoproliferative disorder. It is difficult to differentiate between PCD and IgG4-related disease (IgG4-RD) based on histology alone. As PCD often presents with abundant hemosiderin deposition, lymph node lesions obtained from 22 PCD patients and 12 IgG4-RD patients were analyzed using Prussian blue staining to clarify whether hemosiderin deposition is effective in distinguishing between these two diseases. The analysis disclosed that hemosiderin was more densely deposited in PCD than in IgG4-RD. The median number of Prussian blue-positive cells ± standard deviation (SD) in PCD and IgG4-RD cases was 13 ± 36 cells/3HPFs and 4 ± 8 cells/3HPFs (P = 0.034), respectively. In addition, we analyzed the relationship between hemosiderin deposition and levels of serum interleukin (IL)-6, serum C-reactive protein (CRP), and anemia-related biomarkers. We found that hemosiderin deposition was significantly correlated with the level of serum CRP (P = 0.045); however, no significant correlation was observed between hemosiderin deposition and serum IL-6 levels (P = 0.204). A non-significant positive correlation was observed between hemosiderin deposition and serum hemoglobin levels (P=0.09). Furthermore, no significant correlation was observed between hemosiderin deposition and serum iron levels (P = 0.799). In conclusion, hemosiderin deposition characteristically observed in PCD may be related to the inflammatory aggressiveness of the disease and could be used for its differential diagnosis.

    DOI: 10.3960/jslrt.19037

    PubMed

    researchmap

  • 形質細胞型キャッスルマン病とIgG4関連疾患の肺病変の鑑別におけるIL-6免疫染色の有用性

    西村 碧フィリーズ, 井川 卓朗, 吉野 正, 佐藤 康晴

    日本病理学会会誌   109 ( 1 )   479 - 480   2020年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • Triple-negative pleomorphic lobular carcinoma and expression of androgen receptor: Personal case series and review of the literature. 国際誌

    Kohei Taniguchi, Shinichi Takada, Masako Omori, Takuro Igawa, Midori Filiz Nishimura, Toshiaki Morito, Kouichi Ichimura, Tadashi Yoshino

    PloS one   15 ( 7 )   e0235790   2020年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pleomorphic lobular carcinoma (PLC) is a histological variant of invasive lobular carcinoma (ILC) and is associated with worse prognosis than classical ILC. It exhibits a greater degree of cellular atypia and pleomorphism and is occasionally accompanied with apocrine morphology. We investigated the immunohistochemical characteristics of samples from 31 Japanese patients with PLC to elucidate the clinicopathological characteristics of PLC including androgen receptor (AR) immunoreactivity. The surrogate molecular subtypes were luminal A-like, luminal B-like, luminal B-like/HER2, HER2-type, and triple-negative in 5, 4, 3, 5, and 14 cases, respectively. AR was positive in 92.8% (13/14) of the triple-negative PLC cases and 100% (10/10) of the non-triple-negative PLC cases. Disease-specific survival was worse in patients with histological grade 3 PLCs than in those with histological grade 2 PLCs (p = 0.007). However, there was no significant difference in the progression-free survival between the two groups (p = 0.152). No other clinicopathological characteristics were associated with prognosis. These results reveal that PLC exhibits various surrogate molecular subtypes and that the triple-negative subtype frequently expresses AR. The observed molecular apocrine differentiation implicates that triple-negative PLC can be categorized into the luminal AR subtype. Furthermore, AR-targeted therapy might be useful for patients with triple-negative PLC.

    DOI: 10.1371/journal.pone.0235790

    PubMed

    researchmap

  • Hepatic Campylobacter jejuni infection in patients with Castleman-Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome). 国際誌

    Chihiro Kageyama, Takuro Igawa, Yuka Gion, Noriko Iwaki, Tetsuya Tabata, Takehiro Tanaka, Eisei Kondo, Hajime Sakai, Koichi Tsuneyama, Kazuhiro Nomoto, Hiroko Noguchi, Tadashi Yoshino, Kenji Yokota, Yasuharu Sato

    Pathology international   69 ( 10 )   572 - 579   2019年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Castleman-Kojima disease, also known as idiopathic multicentric Castleman disease with TAFRO syndrome (iMCD-TAFRO), is a recently recognized systemic inflammatory disorder with a characteristic series of clinical symptoms, including thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Patients with iMCD-TAFRO often develop severe abdominal pain, elevated alkaline phosphatase levels, and systemic inflammation, but the etiological factors are unknown. To investigate the potential role of bacterial infection in the pathogenesis of iMCD-TAFRO, we performed polymerase chain reaction (PCR) for the bacterial 16S rRNA gene with DNA extracted from liver specimens of three patients with iMCD-TAFRO, four patients with amyotrophic lateral sclerosis, and seven patients with inflammatory conditions. Sequencing of the PCR product showed 99% DNA sequence identity with Campylobacter jejuni in all three patients with iMCD-TAFRO and in two patients with inflammatory conditions. Immunohistochemical and electron microscopy analyses could not identify C. jejuni in patients with iMCD-TAFRO. The findings indicated that C. jejuni infection is not the pathological cause of iMCD-TAFRO; however, this ubiquitous bacterium may play a role in uncontrolled systemic hypercytokinemia, possibly through the development of cross-reactive autoantibodies.

    DOI: 10.1111/pin.12856

    PubMed

    researchmap

  • Small intestinal intussusception in an adult. 国際誌

    Kenji Takada, Nobukazu Fujimoto, Taichi Ozeki, Jun Nishimura, Yosuke Miyamoto, Michiko Asano, Yasuko Fuchimoto, Sae Wada, Shinji Ozaki, Takuro Igawa, Hiroshi Sonobe, Takumi Kishimoto

    Journal of clinical pathology   72 ( 7 )   510 - 510   2019年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/jclinpath-2017-204973

    PubMed

    researchmap

  • IgG4関連疾患との鑑別に苦慮したhyper-IL-6 syndrome

    寺尾 俊紀, 山本 和彦, 池内 一廣, 若林 宏, 井川 卓朗, 井上 大, 小田 和歌子, 大山 矩史, 鴨井 千尋, 住居 優一, 白石 雄太郎, 山本 宜和, 新谷 大悟, 塩手 康弘, 佐藤 康晴, 吉野 正, 今城 健二

    臨床血液   60 ( 5 )   392 - 397   2019年

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本血液学会-東京事務局  

    発熱、頸部リンパ節腫脹で受診した69歳男性。IgG、IgG4は著明に上昇し、CTで全身リンパ節腫脹、両側涙腺顎下腺腫大、膵体尾部腫大を認め、MRIで膵のソーセージ様腫大を呈し、IgG4関連疾患(IgG4-RD)の臨床所見に合致していた。リンパ節生検では、IgG4/IgG陽性細胞比は40%を超えていたが、拡張した濾胞間領域にIL-6陽性形質細胞の浸潤を認め、組織学的にidiopathic multicentric Castleman disease(iMCD)を含むhyper-IL-6 syndromeの像であった。初期治療であるPSLの内服にて症状は軽快し、低用量で長期寛解を維持している。IgG4-RDとiMCDを含むhyper-IL-6 syndromeとの鑑別が困難であった例を経験し、その骨髄所見も含め、文献的考察を加え報告する。(著者抄録)

    DOI: 10.11406/rinketsu.60.392

    PubMed

    researchmap

    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J01540&link_issn=&doc_id=20190614340007&doc_link_id=130007659581&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007659581&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

  • The efficacy and safety of anti-interleukin-6 receptor monoclonal blockade in a renal transplant patient with Castleman disease: early post-transplant outcome. 国際誌

    Masatoshi Matsunami, Yoshifumi Ubara, Keiichi Sumida, Yoichi Oshima, Masahiko Oguro, Kazuya Kinoshita, Kiho Tanaka, Yuki Nakamura, Keiichi Kinowaki, Kenichi Ohashi, Takeshi Fujii, Takuro Igawa, Yasuharu Sato, Yasuo Ishii

    BMC nephrology   19 ( 1 )   263 - 263   2018年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disease characterized by systemic inflammatory reactions associated with the dysregulated production of interleukin-6 (IL-6). In patients with MCD, renal involvement is uncommon, with only one report published regarding kidney transplantation (KTx) to treat end-stage renal disease (ESRD) secondary to MCD. Recent clinical observations have shown that IL-6 production is implicated in allograft rejection, while IL-6 receptor blockade (with tocilizumab [TCZ]) reduces alloantibody generation and thereby improves graft survival; however, the efficacy and safety of TCZ in MCD patients undergoing KTx is still unknown. CASE PRESENTATION: Herein, we describe the case of a 50-year-old man with MCD who received living-donor KTx for ESRD. Post-operative immunosuppression consisted of a triple-drug regimen (tacrolimus, mycophenolate mofetil and methylprednisolone) with TCZ that was administered intravenously every 2 weeks. At 17 months post-transplantation, the patient remains asymptomatic, and the allograft pathology has shown no evidence of rejection and no development of de novo donor-specific antibody (DSA). CONCLUSIONS: To our knowledge, this is the second reported case of an MCD patient with ESRD who underwent successful KTx. TCZ safely supported the patient during the perioperative period, and this drug may be useful for blocking the generation of donor-specific antibodies and reducing the risk of rejection episodes. KTx in combination with TCZ is thus considered a viable treatment option for ESRD due to MCD.

    DOI: 10.1186/s12882-018-1065-4

    PubMed

    researchmap

  • TAFRO Syndrome. 国際誌

    Takuro Igawa, Yasuharu Sato

    Hematology/oncology clinics of North America   32 ( 1 )   107 - 118   2018年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    TAFRO syndrome is a newly recognized variant of idiopathic multicentric Castleman disease (iMCD) that involves a constellation of syndromes: thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), and organomegaly (O). Thrombocytopenia and severe anasarca accompanied by relatively low serum immunoglobulin levels are characteristic clinical findings of TAFRO syndrome that are not present in iMCD-not otherwise specified (iMCD-NOS). Lymph node biopsy is recommended to exclude other diseases and to diagnose TAFRO syndrome, which reveals characteristic histopathological findings similar to hyaline vascular-type CD. TAFRO syndrome follows a more aggressive course, compared with iMCD-NOS, and there is no standard treatment.

    DOI: 10.1016/j.hoc.2017.09.009

    PubMed

    researchmap

  • A possible new morphological variant of mantle cell lymphoma with plasma-cell type Castleman disease-like features. 国際誌

    Takuro Igawa, Rika Omote, Hiaki Sato, Kohei Taniguchi, Katsuya Miyatani, Tadashi Yoshino, Yasuharu Sato

    Pathology, research and practice   213 ( 11 )   1378 - 1383   2017年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by overexpression of cyclin D1 resulting from t(11;14)(q13;q32) translocation. Herein, we report 3 cases of MCL with features of plasma cell-type Castleman disease (CD). The 3 patients were all men, ranging from 51 to 74 years in age, and they all presented with systemic lymphadenopathy with anemia, hypoalbuminemia, elevated serum levels of C-reactive protein, and polyclonal hypergammaglobulinemia. Lymph node biopsy specimens of the 3 cases showed histological features of plasma cell-type CD, including atrophic germinal centers and interfollicular plasmacytosis, with no light chain restriction. However, flow cytometric analysis demonstrated an abnormal B-cell population with CD5 expression, and further analysis using cyclin D1 immunostaining highlighted a neoplastic component that was restricted to the mantle zone. These neoplastic cells were immunohistochemically positive for CD20, CD5, and SOX11, and negative for CD3, CD10, and HHV8. The Ki67 index was low. All patients were finally diagnosed with MCL. This rare type of MCL can be misdiagnosed clinically and histologically as CD. Therefore, it is important to recognize this rare type of MCL, and careful examination is required using both histological and flow cytometric analyses.

    DOI: 10.1016/j.prp.2017.09.015

    PubMed

    researchmap

  • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue with plasma cell differentiation: Periodic acid-schiff reaction-positive Dutcher body is a diagnostic clue to distinguish it from plasmacytoma. 国際誌

    Atsuko Nasu, Takuro Igawa, Hiaki Sato, Hiroyuki Yanai, Tadashi Yoshino, Yasuharu Sato

    Diagnostic cytopathology   45 ( 6 )   547 - 551   2017年6月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We herein report a case of primary parotid extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with Dutcher bodies. An 82-year-old man presented with a 4 cm × 2.5 cm mass in the left parotid region. Positron emission tomography/computed tomography (PET/CT) showed localized abnormal fluorodeoxyglucose (FDG) uptake in the left parotid gland and lymph nodes of the left cervical region. Fine needle aspiration (FNA) cytology of the left parotid gland showed lymphoplasmacytoid cells with periodic acid-Schiff (PAS)-positive Dutcher bodies. A subsequent excisional biopsy showed sheets of small- to medium-sized neoplastic B cells with abundant IgM in the cytoplasm as detected by immunohistochemistry. A diagnosis of stage II MALT lymphoma was made, but the patient did not receive therapeutic intervention. As previously reported, Dutcher bodies are mainly observed in B-cell neoplasms with IgM production. Because these characteristic intranuclear inclusions can be easily observed by PAS staining, the presence of PAS reaction-positive Dutcher bodies in FNA cytology can serve as a clue to differentially diagnose MALT lymphoma from plasmacytoma. Diagn. Cytopathol. 2017;45:547-551. © 2017 Wiley Periodicals, Inc.

    DOI: 10.1002/dc.23691

    PubMed

    researchmap

  • Immunohistochemical analysis of IgA expression differentiates IgG4-related disease from plasma cell-type Castleman disease.

    Akihiro Manabe, Takuro Igawa, Mai Takeuchi, Yuka Gion, Tadashi Yoshino, Yasuharu Sato

    Medical molecular morphology   50 ( 1 )   34 - 41   2017年3月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Plasma cell-type Castleman disease (PCD) is often encountered when differentiating IgG4-related disease (IgG4-RD). Given that serum IgA is often elevated in Castleman disease, we investigated whether IgA expression levels in histological specimens can be used to differentiate between the two diseases. Lymph node lesions obtained from 12 IgG4-RD and 11 PCD patients were analysed by immunohistochemistry with anti-IgG, -IgG4, and -IgA antibodies. In addition to all 12 cases of IgG4-RD, 8/11 cases (72.7 %) of PCD also met the diagnostic criteria of IgG4-RD (serum IgG4 ≥135 mg/dl and IgG4/IgG-positive cells ≥40 %). IgA-positive cells were sparsely and densely distributed in IgG4-RD and PCD cases, respectively. The median number of IgA-positive cells ± SD in all 12 cases of IgG4-RD was 31 ± 37 cells per three high-powered fields (3HPFs) (range 4-118 cells/3HPFs). In contrast, the median number of IgA-positive cells, which was significantly higher in all 11 cases of PCD, was 303 ± 238 cells/3HPFs (range 74-737 cells/3HPFs) (P < 0.001). In conclusion, our findings indicate that in cases where serum analysis-based data are unavailable, anti-IgA immunostaining can be used for differential diagnosis of IgG4-RD.

    DOI: 10.1007/s00795-016-0145-4

    PubMed

    researchmap

  • IgG4-producing lymphoma arising in a patient with IgG4-related disease.

    Takuro Igawa, Toshiaki Hayashi, Kazuya Ishiguro, Yumiko Maruyama, Mai Takeuchi, Katsuyoshi Takata, Tadashi Yoshino, Yasuharu Sato

    Medical molecular morphology   49 ( 4 )   243 - 249   2016年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We herein report a case in which an IgG4-producing lymphoma arose in a patient with a previous diagnosis consistent with an IgG4-related disease. A 43-year-old man presented with enlarged cervical lymph nodes and was treated with steroids and radiation for what was initially assumed to be Kimura's disease, although the lesions were later histologically re-diagnosed as IgG4-related lymphadenopathy. Fourteen years later, when the patient was 58-years-old, he presented with retroperitoneal fibrosis and swollen lymph nodes. The suspicious lesions were not histologically examined as the patient did not give consent. However, the serum IgG4 concentration was high (1400 mg/dL) and he was clinically diagnosed with systemic IgG4-related disease. Although steroid administration reduced the size of the lesions, tapering the dose finally resulted in systemic, prominently enlarged lymph nodes. Analysis of the biopsy specimen revealed that these multiple lymph node lesions were marginal zone B cell lymphomas that themselves expressed IgG4. Complete remission was achieved after a total of six courses of chemotherapy including rituximab. This case suggests that the infiltrating IgG4-expressing cells observed in IgG4-related disease can clonally expand to malignant lymphomas.

    PubMed

    researchmap

  • Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient. 国際誌

    Takuro Igawa, Yasuharu Sato, Hotaka Kawai, Eisei Kondo, Mai Takeuchi, Tomoko Miyata-Takata, Katsuyoshi Takata, Tadashi Yoshino

    Diagnostic pathology   10   183 - 183   2015年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Plasmablastic lymphoma (PBL) is an aggressive lymphoma commonly associated with human immunodeficiency virus (HIV) infection. Herein we describe a rare case of PBL that spontaneously regressed. An 80-year-old man was referred to our hospital owing to an exophytic gingival tumor in the right maxillary second molar region. He had no significant past medical history, and a screening test for HIV was negative. Imaging showed that the tumor measured 26 × 23 × 16 mm and was confined in the alveolar bone. The tumor was histologically comprised of highly proliferative immunoblastic cells positive for CD138 and Epstein-Barr virus (EBV)-encoded RNA. Monoclonal IgH chain gene rearrangement was detected via polymerase chain reaction. After biopsy and diagnosis of PBL, the tumor began to decrease in size and had apparently disappeared at the time of surgery. There was no histological evidence of a residual lesion in the surgical specimen. In conclusion, a minority of immunosenescence-associated PBLs in the elderly should be recognized as a unique clinicopathological entity distinct from common aggressive PBL.

    DOI: 10.1186/s13000-015-0421-y

    PubMed

    researchmap

  • Severe liver injury associated with simeprevir plus pegylated interferon/ribavirin therapy in a patient with treatment-naïve genotype 1b hepatitis C virus: a case report.

    Takuro Igawa, Soichiro Fushimi, Ryuichi Matsuo, Fusao Ikeda, Kazuhiro Nouso, Tadashi Yoshino, Harushige Nakatsukasa

    Clinical journal of gastroenterology   7 ( 5 )   465 - 70   2014年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A second-generation direct-acting antiviral agent, simeprevir, now provides a new treatment option for hepatitis C virus (HCV) infection with good safety profile in combination with pegylated interferon and ribavirin. We herein report a rare case of severe liver injury under simeprevir plus pegylated interferon/ribavirin therapy. We initiated this therapy in a 65-year-old male with treatment-naïve genotype 1b HCV. On day 28, the patient's HCV-RNA was successfully eliminated, and his liver function was fully restored. However, on day 49, the serum alanine aminotransferase level was elevated at 700 IU/L. The HCV-RNA titer was still undetectable and the involvement of other possible viruses was negligible. A liver biopsy performed on day 60 showed an acute hepatitis pattern. The discontinuation of therapy alone successfully improved his liver damage on day 84. No other treatments such as steroids were required. According to the diagnostic criteria for drug-induced liver injury in Japan (DDW-J2004), the liver injury observed in this case can be associated with the administration of simeprevir plus pegylated interferon/ribavirin therapy. In conclusion, simeprevir plus pegylated interferon/ribavirin should be used with caution, as these agents may cause unreported serious adverse events including severe liver injury, despite their clinical safety profile.

    DOI: 10.1007/s12328-014-0527-x

    PubMed

    researchmap

  • De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression. 国際誌

    Takuro Igawa, Yasuharu Sato, Katsuyoshi Takata, Noriko Iwaki, Takehiro Tanaka, Naoko Asano, Yoshinobu Maeda, Yorihisa Orita, Naoya Nakamura, Shigeo Nakamura, Tadashi Yoshino

    Diagnostic pathology   8   81 - 81   2013年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    UNLABELLED: D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1382856320966453.

    DOI: 10.1186/1746-1596-8-81

    PubMed

    researchmap

  • Minimally invasive procedure for accurate diagnosis of mucosa-associated lymphoid tissue lymphoma of the head and neck. 国際誌

    Yorihisa Orita, Yasuharu Sato, Eisei Kondo, Hisashi Ishihara, Haruka Hirai, Hiroyuki Hanakawa, Tomoo Onoda, Takuro Igawa, Ryusuke Saito, Kazunori Nishizaki, Tadashi Yoshino

    Japanese journal of clinical oncology   42 ( 4 )   325 - 30   2012年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Sonography-guided cutting needle biopsy for the diagnosis of malignant lymphoma has recently come into wide use. However, surgery is sometimes unavoidable for the diagnosis of malignant lymphoma, particularly for low-grade malignant lymphoma such as extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, because cutting needle biopsy offers limited diagnostic accuracy for low-grade malignant lymphoma. Of course, unnecessary invasive procedures like open biopsy should be avoided wherever possible, given the cosmetic problems and burden on the patient. We tried to diagnose malignant lymphoma using the combination of cutting needle biopsy, flow cytometry and polymerase chain reaction to identify monoclonal rearrangement of immunoglobulin heavy chain genes. We have used this method in two cases in whom malignant lymphoma was suspected in the head and neck region, allowing diagnosis of mucosa-associated lymphoid tissue lymphoma in both cases. One case involved a 23-year-old woman with mucosa-associated lymphoid tissue lymphoma in the parotid glands, and the other involved a 77-year-old man with mucosa-associated lymphoid tissue lymphoma in the thyroid. The combination of cutting needle biopsy, flow cytometry and immunoglobulin heavy chain gene rearrangement testing might offer a useful alternative to open biopsy for the diagnosis of mucosa-associated lymphoid tissue lymphoma. We recommend this procedure, particularly for young women or patients with poor performance status in whom malignant lymphoma is suspected.

    DOI: 10.1093/jjco/hys011

    PubMed

    researchmap

  • Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma. 国際誌

    Takuro Igawa, Yasuharu Sato, Katsuyoshi Takata, Soichiro Fushimi, Maiko Tamura, Naoya Nakamura, Yoshinobu Maeda, Yorihisa Orita, Mitsune Tanimoto, Tadashi Yoshino

    Cancer science   102 ( 11 )   2103 - 7   2011年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The D cyclins are important cell cycle regulatory proteins involved in the pathogenesis of some lymphomas. Cyclin D1 overexpression is a hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 have not been shown to be closely associated with any particular subtype of lymphoma. In the present study, we found that cyclin D2 was specifically overexpressed in the proliferation centers (PC) of all cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) examined (19/19). To examine the molecular mechanisms underlying this overexpression, we immunohistochemically examined the expression of nuclear factor (NF)-κB, p15, p16, p18, and p27 in the PC of six patients. Five cases showed upregulation of NF-κB expression, which is known to directly induce cyclin D2 by binding to the promoter region of CCND2. All six PC examined demonstrated downregulation of p27 expression. In contrast, upregulation of p15 expression was detected in five of six PC examined. This discrepancy suggests that unknown cell cycle regulatory mechanisms involving NF-κB-related pathways are also involved, because NF-κB upregulates cyclin D2 not only directly, but also indirectly through c-Myc, which is believed to downregulate both p27 and p15. In conclusion, cyclin D2 is overexpressed in the PC of CLL/SLL and this overexpression is due, in part, to the upregulation of NF-κB-related pathways.

    DOI: 10.1111/j.1349-7006.2011.02046.x

    PubMed

    researchmap

▼全件表示

MISC

  • B細胞性リンパ腫におけるIRTA-1発現の検討

    田端 哲也, 井川 卓朗, 田中 健大, 佐藤 康晴, 吉野 正

    日本病理学会会誌   110 ( 1 )   359 - 359   2021年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • TAFRO症候群患者における肝臓のCampylobacter jejuni感染症(Hepatic Campylobacter jejuni infection in patients with TAFRO syndrome)

    井川 卓朗, 佐藤 康晴, 吉野 正

    日本病理学会会誌   109 ( 1 )   480 - 480   2020年3月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • 古典的ホジキンリンパ腫におけるEBV DNAコード化microRNA BART12の欠失(Deletion of EBV DNA encoding microRNA BART12 in classic Hodgkin lymphoma)

    川月 章弘, 井川 卓朗, 田端 哲也, 田中 健大, 吉野 正

    日本病理学会会誌   109 ( 1 )   503 - 503   2020年3月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • 形質細胞型キャッスルマン病とIgG4関連疾患の肺病変の鑑別におけるIL-6免疫染色の有用性

    西村 碧フィリーズ, 井川 卓朗, 吉野 正, 佐藤 康晴

    日本病理学会会誌   109 ( 1 )   479 - 480   2020年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • 自然消退を来したplasmablastic lymphomaの二例

    池田 知佳, 井川 卓朗, 吉野 正, 佐藤 康晴

    日本病理学会会誌   109 ( 1 )   404 - 404   2020年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • リンパ節生検捺印細胞診が診断の契機となった未分化大細胞型リンパ腫の一例

    宍戸 優, 藤田 健太, 原田 侑香里, 松田 正浩, 永喜多 敬奈, 神農 陽子, 谷口 香, 井川 卓朗, 吉野 正

    岡山県臨床細胞学会誌   38   22 - 26   2019年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:岡山県臨床細胞学会  

    背景:左腋窩リンパ節生検において、捺印細胞診が診断の契機となったALK(Anaplastic lymphoma kinase)陽性ALCL(Anaplastic large cell lymphoma)の一例を経験したので報告する。症例:40代、女性。近医にて、発熱および左腋窩リンパ節腫大で経過観察していたが、痛みが出現し、当院血液内科に紹介された。血液検査で可溶性IL-2レセプターが6,764U/mLと高値であり、リンパ節生検が施行された。組織像ではリンパ節の構造は破壊され、中型主体のリンパ腫様細胞が出現し、一部で大型異型細胞が見られた。免疫染色の結果よりT-cell lymphomaが疑われた。リンパ節生検時に作製した捺印細胞診標本では、馬蹄形核やドーナッツ状細胞など多形性に富んだ大型異型細胞が少数孤立散在性に観察された。いわゆるhallmark cellと考えられ、ALCLを疑う所見であった。これを受けて組織標本にて追加免疫染色を施行したところ、CD30、ALK、TIA/GranzymeBが広く陽性を呈した。フローサイトメトリー(以下FCM)および染色体G-band検査の結果と総合し、ALK陽性ALCLと診断された。まとめ:本症例では、組織標本ではALCLに特徴的な異型細胞が少数で観察しづらかったが、捺印細胞診では個々の細胞を詳細に観察することができ、少数であってもhallmark cellと考えられる異型細胞が確認できた。それによりALCLを疑い、FCMや免疫染色などの追加検索に繋がり、診断確定への一助となった。細胞診断を併用することの有用性が改めて認識できた一例であった。(著者抄録)

    researchmap

  • 特徴的な組織像を呈したPeripheral T-cell lymphoma with T-follicular helper phenotypeの一例

    西村 碧フィリーズ, 井川 卓朗, 田端 哲也, 田中 健大, 佐藤 康晴, 吉野 正

    日本リンパ網内系学会会誌   59   132 - 132   2019年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • 腎生検にて診断に至った血管内リンパ腫症例(Intravascular lymphoma proven by renal needle biopsy)

    葛目 亜弓, 新谷 大悟, 白石 雄太郎, 花山 宜久, 築地 友紘, 井川 卓朗, 柴田 嶺, 大山 矩史, 鴨井 千尋, 住居 優一, 山本 宜和, 山本 和彦, 近藤 英生, 今城 健二, 吉野 正

    臨床血液   59 ( 9 )   1786 - 1786   2018年9月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本血液学会-東京事務局  

    researchmap

  • 小児に発症したprimary cutaneous CD4+ small/medium T-cell lymphoproliferative disorderの一例

    西田 賢司, 佐藤 康晴, 藤木 俊寛, 前田 進太郎, 田端 哲也, 井川 卓朗, 田中 健大, 吉野 正

    日本リンパ網内系学会会誌   58   120 - 120   2018年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • TAFRO症候群を伴う特発性多中心性キャッスルマン病患者の3症例における肝臓Campylobacter jejuni感染症(Hepatic Campylobacter jejuni infection present in three idiopathic multicentric Castleman disease patients with TAFRO syndrome)

    井川 卓朗, 影山 千紘, 横田 憲治, 吉野 正, 佐藤 康晴

    日本リンパ網内系学会会誌   58   122 - 122   2018年5月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • Plasma-Cell Type Castleman DiseaseにおけるIL-6発現の検討

    杉 貴臣, 川本 雅也, 井川 卓朗, 佐藤 康晴, 吉野 正

    日本病理学会会誌   107 ( 1 )   527 - 527   2018年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • AZA加療中の潰瘍性大腸炎患者に発症したEBV-associated B-cell lymphoproliferative disordersの1例

    表 梨華, 田中 健大, 井川 卓朗, 佐藤 康晴, 吉野 正

    日本病理学会会誌   107 ( 1 )   439 - 439   2018年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • 【節外性リンパ腫診療の進歩】消化管MALTリンパ腫の特性

    井川 卓朗, 岡崎 倫子, 吉野 正

    血液内科   76 ( 3 )   346 - 351   2018年3月

     詳細を見る

    記述言語:日本語   出版者・発行元:(有)科学評論社  

    researchmap

  • IgG4関連疾患におけるランゲルハンス細胞様樹状細胞による抗原提示の可能性

    竹内 真衣, 祇園 由佳, 林 詠子, 井川 卓朗, 佐藤 康晴, 吉野 正

    日本リンパ網内系学会会誌   57   89 - 89   2017年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • IgA免疫染色によるIgG4関連疾患と形質細胞型キャッスルマン病の鑑別(IgA immunostaining differentiates IgG4-related disease from plasma cell-type Castleman disease)

    井川 卓朗, 佐藤 康晴, 吉野 正

    日本リンパ網内系学会会誌   57   109 - 109   2017年5月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • IgG4関連疾患におけるランゲルハンス細胞様樹状細胞による抗原提示の可能性

    竹内 真衣, 祇園 由佳, 林 詠子, 井川 卓朗, 佐藤 康晴, 吉野 正

    日本リンパ網内系学会会誌   57   110 - 110   2017年5月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • 免疫染色によるIgAの発現検索はIgG4関連疾患と形質細胞型キャッスルマン病の鑑別を可能にする(IgA immunostaining differentiates IgG4-related disease from plasma cell-type Castleman disease)

    井川 卓朗, 佐藤 康晴, 吉野 正

    日本病理学会会誌   106 ( 1 )   354 - 354   2017年3月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • P-CABを用いたH.pyloriの1次除菌療法は本当に除菌率を改善できるか? 従来型PPIやパック製剤を用いた除菌率との比較から見えてくるもの

    平松 万尚, 松尾 恵輔, 春田 祐郎, 松尾 晃樹, 松尾 泰治, 宮川 美子, 小松 万寿美, 大西 信彦, 表 静馬, 井川 卓朗, 砂田 光俊

    広島医学   69 ( 11 )   762 - 763   2016年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:広島医学会  

    researchmap

  • ワーファリンとグルコサミン含有健康食品の相互作用で出血をきたした一例

    松尾 恵輔, 春田 祐郎, 松尾 晃樹, 平松 万尚, 宮川 美子, 松尾 泰治, 小松 万寿美, 大西 信彦, 表 静馬, 井川 卓朗, 清家 圭介, 尾畑 昇悟

    広島医学   69 ( 11 )   760 - 760   2016年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:広島医学会  

    researchmap

  • 当院への腎疾患紹介患者の経過と地域での取り組み

    松尾 晃樹, 松尾 恵輔, 春田 祐郎, 平松 万尚, 松尾 泰治, 宮川 美子, 小松 万寿美, 大西 信彦, 表 静馬, 井川 卓朗, 清家 圭介

    広島医学   69 ( 11 )   760 - 761   2016年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:広島医学会  

    researchmap

  • IgG4関連疾患患者から生じたIgG4産生リンパ腫(IgG4-producing lymphoma arising in a patient with IgG4-related disease)

    井川 卓朗, 佐藤 康晴, 高田 尚良, 吉野 正

    日本病理学会会誌   105 ( 1 )   496 - 496   2016年4月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • IgG4関連リンパ節症におけるマスト細胞のIgE発現とその意義

    西田 賢司, 竹内 真衣, 片岡 竜貴, 井川 卓朗, 吉野 正, 佐藤 康晴

    日本病理学会会誌   105 ( 1 )   393 - 393   2016年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • 健康食品「クランベリー・ジュース」による高齢者の尿路結石溶解(その2)

    松尾 恵輔, 春田 祐郎, 松尾 晃樹, 宮川 美子, 平松 万尚, 小松 万寿美, 黒井 大雅, 大西 信彦, 表 静馬, 井川 卓朗

    広島医学   68 ( 8 )   459 - 459   2015年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:広島医学会  

    researchmap

  • 喀痰細胞よりEGFR変異(エクソン19欠失)を認め、ゲフィチニブ単独投与にて著効を示したStage IV PS3肺癌患者の1症例

    春田 祐郎, 松尾 恵輔, 松尾 晃樹, 宮川 美子, 平松 万尚, 小松 万寿美, 黒井 大雅, 大西 信彦, 表 静馬, 井川 卓朗

    広島医学   68 ( 8 )   460 - 461   2015年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:広島医学会  

    researchmap

  • 尾三地区でも発見されるCrowned dens syndromeの2例

    平松 万尚, 松尾 恵輔, 春田 祐郎, 松尾 晃樹, 宮川 美子, 小松 万寿美, 黒井 大雅, 大西 信彦, 表 静馬, 井川 卓朗, 久田 彰史, 砂田 光俊

    広島医学   68 ( 8 )   456 - 456   2015年8月

     詳細を見る

    記述言語:日本語   出版者・発行元:広島医学会  

    researchmap

  • 未治療で自然消褪をきたした右上顎歯肉plasmablastic lymphomaの一例

    井川 卓朗, 佐藤 康晴, 高田 尚良, 吉野 正

    日本リンパ網内系学会会誌   55   110 - 110   2015年6月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    researchmap

  • 新生CD5陽性のびまん性大細胞型B細胞性リンパ腫はサイクリンD2に対して高い特異性を示す(De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2)

    井川 卓朗, 佐藤 康晴, 高田 尚良, 吉野 正

    日本病理学会会誌   104 ( 1 )   494 - 494   2015年3月

     詳細を見る

    記述言語:英語   出版者・発行元:(一社)日本病理学会  

    researchmap

  • 【低悪性度B細胞リンパ腫の研究と診療-Update in 2012-】慢性リンパ性白血病/小細胞性リンパ腫(CLL/SLL)とcyclin D2

    佐藤 康晴, 井川 卓朗, 吉野 正

    血液内科   65 ( 1 )   27 - 32   2012年7月

     詳細を見る

    記述言語:日本語   出版者・発行元:(有)科学評論社  

    researchmap

▼全件表示

 

担当授業科目

  • 病理学Ⅱ (2021年度) 特別  - その他

  • 病理学Ⅱ実習 (2021年度) 特別  - その他

  • 病理学(腫瘍病理)I(演習・実習) (2021年度) 特別  - その他

  • 病理学(腫瘍病理)I(講義・演習) (2021年度) 特別  - その他

  • 病理学(腫瘍病理)II(演習・実習) (2021年度) 特別  - その他

  • 病理学(腫瘍病理)II(講義・演習) (2021年度) 特別  - その他

  • 病理病態学 (2021年度) 集中  - その他

  • 病理学Ⅱ (2020年度) 特別  - その他

  • 病理学Ⅱ実習 (2020年度) 特別  - その他

  • 病理学(腫瘍病理)I(演習・実習) (2020年度) 特別  - その他

  • 病理学(腫瘍病理)I(講義・演習) (2020年度) 特別  - その他

  • 病理学(腫瘍病理)II(演習・実習) (2020年度) 特別  - その他

  • 病理学(腫瘍病理)II(講義・演習) (2020年度) 特別  - その他

  • 病理病態学 (2020年度) 集中  - その他

▼全件表示