Faculty Profiles - TAKAKI Akinobu

Papers - TAKAKI Akinobu

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The relationship between the PD-L1 expression of surgically resected and fine-needle aspiration specimens for patients with pancreatic cancer. Reviewed

Matsumoto K, Ohara T, Fujisawa M, Takaki A, Takahara M, Tanaka N, Kato H, Horiguchi S, Yoshida R, Umeda Y, Fushimi S, Yagi T, Matsukawa A, Okada H

Journal of gastroenterology 54 ( 11 ) 1019 - 1028 2019.11

膵癌におけるFNA検体と切除検体とのPD-L1発現の検討 Reviewed

松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博, 岡田裕之

日本消化器病学会雑誌 116 ( 臨増大会 ) A826 - A826 2019.11

膵癌におけるFNA検体と切除検体とのPD-L1発現の検討

松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博, 岡田裕之

日本消化器病学会雑誌 116 ( 臨増大会 ) A826 - A826 2019.11

DAA治療後のSVR後発癌についての検討

和田望, 大山淳史, 足立卓哉, 坂田雅浩, 安中哲也, 大西秀樹, 白羽英則, 高木章乃夫, 岡田裕之

肝臓 60 ( Suppl.3 ) A847 - A847 2019.11

原発性硬化性胆管炎(PSC)予後予測因子の検討

大山淳史, 高木章乃夫, 足立卓哉, 和田望, 坂田雅浩, 安中哲也, 大西秀樹, 白羽英則, 岡田裕之

日本消化器病学会雑誌 116 ( 臨増大会 ) A849 - A849 2019.11

レンバチニブで長期効果見込める肝細胞癌症例の特徴

足立卓哉, 能祖一裕, 大山淳史, 和田望, 坂田雅浩, 安中哲也, 大西秀樹, 白羽英則, 高木章乃夫, 狩山和也, 岡田裕之

日本消化器病学会雑誌 116 ( 臨増大会 ) A781 - A781 2019.11

慢性炎症・癌ハイリスク状態対応の最前線肝癌根治的ラジオ波後予後不良に関連する再発例での血清酸化ストレスマーカーの評価

室泰子, 高木章乃夫, 中村進一郎, 大西秀樹, 岡田裕之

日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集 112回・123回 68 - 68 2019.11

肝性浮腫に対するトルバプタン効果に寄与する血管内皮機能の検討

足立卓哉, 高木章乃夫, 佐藤秀一, 大山淳史, 和田望, 坂田雅浩, 安中哲也, 大西秀樹, 白羽英則, 岡田裕之

肝臓 60 ( Suppl.3 ) A853 - A853 2019.11

高齢者におけるDAA治療の現状

和田望, 大山淳史, 足立卓哉, 坂田雅浩, 安中哲也, 大西秀樹, 池田房雄, 白羽英則, 高木章乃夫, 岡田裕之

肝臓 60 ( Suppl.2 ) A657 - A657 2019.10

The Efficacy and Safety of Steroids for Preventing Postembolization Syndrome after Transcatheter Arterial Chemoembolization of Hepatocellular Carcinoma. Reviewed

Kuwaki K, Nouso K, Miyashita M, Makino Y, Hagihara H, Moriya A, Adachi T, Wada N, Yasunaka Y, Yasunaka T, Takeuchi Y, Onishi H, Nakamura S, Ikeda F, Shiraha H, Takaki A, Okada H

Acta medica Okayama 73 ( 4 ) 333 - 339 2019.8

Language：English Publishing type：Research paper (scientific journal)

Steroids are often administered at the time of transcatheter arterial chemoembolization (TACE), a standard treatment of hepatocellular carcinoma (HCC), with the expectation of preventing postembolization syndrome. Here we investigated the precise effects of steroids on TACE. We prospectively enrolled 144 HCC patients from 10 hospitals who underwent TACE. Three hospitals used steroids (steroid group, n=77) and the rest did not routinely use steroids (control group, n=67). The occurrence of adverse events and the algetic degree at 1-5 days post-treatment were compared between the groups. Fever (grades 0-2) after TACE was significantly less in the steroid group (56/21/0) compared to the control group (35/29/3, p=0.005, Cochran-Armitage test for trend). The suppressive effect of steroids against fever was prominent in females (p=0.001). Vomiting (G0/G1/ G2-) was also less frequent in the steroid group (70/5/2) versus the control group (53/10/3), but not significantly (p=0.106). The algetic degree and the grade of hematological adverse events, including hyperglycemia, did not differ between the groups. We conclude that the administration of steroids was useful for the prevention of adverse events after TACE in patients with HCC.

DOI： 10.18926/AMO/56935

PubMed

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Monitoring serum proangiogenic cytokines from hepatocellular carcinoma patients treated with sorafenib. Reviewed International journal

Adachi T, Nouso K, Miyahara K, Oyama A, Wada N, Dohi C, Takeuchi Y, Yasunaka T, Onishi H, Ikeda F, Nakamura S, Shiraha H, Takaki A, Takabatake H, Fujioka SI, Kobashi H, Takuma Y, Iwadou S, Uematsu S, Takaguchi K, Hagihara H, Okada H, Okayama Liver, Cancer Group

Journal of gastroenterology and hepatology 34 ( 6 ) 1081 - 1087 2019.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIM: Several factors, including proangiogenic cytokines, have been reported as predictive markers for the treatment effect of sorafenib in patients with hepatocellular carcinoma (HCC); however, most of them were determined based on one-time measurements before treatment. METHODS: We consecutively recruited 80 advanced HCC patients who were treated with sorafenib prospectively. Serum levels of eight proangiogenic cytokines and the appearance of adverse events were monitored periodically, and their correlations with the prognoses of the patients were evaluated. RESULTS: Among six significant risk factors for overall survival in univariate analyses, high angiopoietin-2 (hazard ratio, 2.06), high hepatocyte growth factor (hazard ratio, 2.08), and poor performance status before the treatment (hazard ratio, 2.48) were determined as independent risk factors. In addition, high angiopoietin-2 at the time of progressive disease was a marker of short post-progression survival (hazard ratio, 4.27). However, there was no significant variable that predicted short progression-free survival except the presence of hepatitis B virus surface antigen. CONCLUSIONS: Predictions of overall survival and post-progression survival were possible by periodically measuring serum proangiogenic cytokines, especially angiopoietin-2, in patients with HCC treated with sorafenib.

DOI： 10.1111/jgh.14535

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肝疾患の診断と治療生体肝移植後経過より再考する肝硬変合併肺病変の評価

大山淳史, 高木章乃夫, 安中哲也, 足立卓哉, 和田望, 坂田雅浩, 大西秀樹, 白羽英則, 吉田龍一, 楳田祐三, 中村一文, 八木孝仁, 岡田裕之

日本消化器病学会四国支部例会プログラム・抄録集 111回 47 - 47 2019.6

THE RELATIONSHIP BETWEEN THE PD-L1 EXPRESSION OF SURGICAL RESECTED AND FINE-NEEDLE ASPIRATION SPECIMENS FOR PATIENTS WITH PANCREATIC CANCER Reviewed

Matsumoto Kazuyuki, Ohara Toshiaki, Fujisawa Masayoshi, Takaki Akinobu, Takahara Masahiro, Kato Hironari, Horiguchi Shigeru, Matsukawa Akihiro, Okada Hiroyuki

GASTROENTEROLOGY 156 ( 6 ) S758 2019.5

Paradoxical Roles of Oxidative Stress Response in the Digestive System before and after Carcinogenesis. Reviewed International journal

Takaki A, Kawano S, Uchida D, Takahara M, Hiraoka S, Okada H

Cancers 11 ( 2 ) 2019.2

Language：English Publishing type：Research paper (scientific journal)

Oxidative stress is recognized as a cancer-initiating stress response in the digestive system. It is produced through mitochondrial respiration and induces DNA damage, resulting in cancer cell transformation. However, recent findings indicate that oxidative stress is also a necessary anticancer response for destroying cancer cells. The oxidative stress response has also been reported to be an important step in increasing the anticancer response of newly developed molecular targeted agents. Oxidative stress might therefore be a cancer-initiating response that should be downregulated in the precancerous stage in patients at risk of cancer but an anticancer cell response that should not be downregulated in the postcancerous stage when cancer cells are still present. Many commercial antioxidant agents are marketed as "cancer-eliminating agents" or as products to improve one's health, so cancer patients often take these antioxidant agents. However, care should be taken to avoid harming the anticancerous oxidative stress response. In this review, we will highlight the paradoxical effects of oxidative stress and antioxidant agents in the digestive system before and after carcinogenesis.

DOI： 10.3390/cancers11020213

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Predictive Factors for Successful Vaccination Against Hepatitis B Surface Antigen in Patients Who Have Undergone Orthotopic Liver Transplantation. Reviewed

Ikeda A, Takaki A, Yasunaka T, Oyama A, Adachi T, Wada N, Onishi H, Ikeda F, Shiraha H, Yoshida K, Kuise T, Nobuoka D, Yoshida R, Umeda Y, Yagi T, Fujiwara T, Okada H

Acta medica Okayama 73 ( 1 ) 41 - 50 2019.2

Language：English Publishing type：Research paper (scientific journal)

Post-orthotopic liver transplantation (OLT) hepatitis B recurrence is well-controlled with a nucleos(t)ide analogue and hepatitis B immunoglobulin (HBIG) combination, but the high cost and the potential risk of unknown infection associated with HBIG remain unresolved issues. Low-cost recombinant hepatitis B virus (HBV) vaccine administration is a potential solution to these problems. We retrospectively analyzed the rate and predictive factors of HBV vaccine success in 49 post-OLT patients: liver cirrhosis-type B (LC-B), n=28 patients; acute liver failure-type B (ALF-B), n=8; and non-HBV-related end-stage liver disease (non-B ESLD) who received a liver from anti-hepatitis B core antibody-positive donors, n=13. A positive anti-hepatitis B surface antibody response was achieved in 29% (8/28) of the LC-B group, 88% (7/8) of the ALF-B group, and 44% (4/9) of the adult non-B ESLD group. All four non-B ESLD infants showed vaccine success. The predictive factors for a good response in LC-B were young age, marital donor, and high donor age. ALF-B and non-B ESLD infants are thus good vaccination candidates. LC-B patients with marital donors are also good candidates, perhaps because the donated liver maintains an efficient immune memory to HBV, as the donors had already been infected in adulthood and showed adequate anti-HBV immune responses.

DOI： 10.18926/AMO/56457

PubMed

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Analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan. Reviewed

Aiso M, Takikawa H, Tsuji K, Kagawa T, Watanabe M, Tanaka A, Sato K, Sakisaka S, Hiasa Y, Takei Y, Ohira H, Ayada M, Hashimoto E, Kaneko S, Ueno Y, Ohmoto K, Takaki A, Torimura T, Matsuzaki Y, Tajiri K, Yoneda M, Ito T, Kato N, Ikejima K, Mochida S, Yasuda H, Sakamoto N

Hepatology research : the official journal of the Japan Society of Hepatology 49 ( 1 ) 105 - 110 2019.1

[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B]. Reviewed

Makita T, Kanzaki H, Onishi H, Ikeda A, Takaki A, Wada N, Takeuchi Y, Yasunaka T, Ikeda F, Shiraha H, Tanaka Y, Nishihara S, Murakawa K, Kitamura Y, Okada H, Sendo T

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 139 ( 4 ) 641 - 645 2019

Publishing type：Research paper (scientific journal)

We herein present the case of a 66-year-old Japanese man with Fanconi's syndrome. He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles. Renal dysfunction, hypophosphatemia, and increased levels of bone alkaline phosphatase were found by a hematology test after admission for treatment of HCC. Radiography and 99m Tc-labeled hydroxymethylene diphosphonate (HMDP) scintigraphy revealed multiple insuficiency fractures in the ribs, knees, ankles, and heels. After switching from ADV to tenofovir disoproxil fumarate (TDF) and treatment with calcitriol and sodium dihydrogenphosphate, the patient's serum phosphate levels slightly increased and renal dysfunction did not improve, but after six months his clinical symptoms disappeared. To detect and prevent adverse effects from ADV, physicians and pharmacists should carefully monitor renal function and serum phosphate levels in patients with hepatitis B virus (HBV) treated for a long time with ADV.

DOI： 10.1248/yakushi.18-00170

Scopus

PubMed

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Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-productive lamina propria CD4+ T cells through AMPK activation Reviewed International journal

Takahara M, Takaki A, Hiraoka S, Adachi T, Shimomura Y, Matsushita H, Nguyen T, Koike K, Ikeda A, Takashima S, Yamasaki Y, Inokuchi T, Kinugasa H, Sugihara Y, Harada K, Eikawa S, Morita H, Udono H, Okada H

Scientific Reports 9 ( 1 ) 11934 - 11934 2019

Language：English Publishing type：Research paper (scientific journal)

The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4+T cell activation in vitro and on the inflammatory responses in T cell transfer mouse models of inflammatory bowel disease (IBD). We examined the favorable effects of BBR in vitro, using lamina propria (LP) CD4+ T cells in T cell transfer IBD models in which SCID mice had been injected with CD4+CD45RBhigh T cells. BBR suppressed the frequency of IFN-γ- and Il-17A-producing LP CD4+ T cells. This effect was found to be regulated by AMPK activation possibly induced by oxidative phosphorylation inhibition. We then examined the effects of BBR on the same IBD models in vivo. BBR-fed mice showed AMPK activation in the LPCD4+ T cells and an improvement of colitis. Our study newly showed that the BBR-induced AMPK activation of mucosal CD4+ T cells resulted in an improvement of IBD and underscored the importance of AMPK activity in colonic inflammation.

DOI： 10.1038/s41598-019-48331-w

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Acquired partial lipoatrophy as graft-versus-host disease and treatment with metreleptin: two case reports. Reviewed

Shibata Y, Nakatsuka A, Eguchi J, Miyamoto S, Masuda Y, Awazawa M, Takaki A, Yoshida R, Yagi T, Wada J

Journal of medical case reports 12 ( 1 ) 368 2018.12

岡山県地域肝炎対策サポーター育成後の活動実態調査肝炎医療コーディネーター活動と部署異動

難波志穂子, 池田房雄, 秋山文男, 石原光将, 下村泰之, 山崎典子, 犬山奈穂美, 小山道弘, 亀川勝典, 大久保進之介, 長谷川祐子, 岩井賢司, 三喜明子, 三浦留美, 矢野香苗, 藤井洋輔, 大山淳史, 足立卓哉, 和田望, 安中幸, 安中哲也, 大西秀樹, 白羽英則, 高木章乃夫, 山野井尚美, 岡田裕之

肝臓 59 ( 11 ) 625 - 632 2018.11

Language：Japanese Publisher：(一社)日本肝臓学会

岡山県では2011年より肝疾患に関わる部署の初任者を対象に肝炎医療研修会を実施し、受講者を地域肝炎対策サポーターと認定してきたが、厚生労働省の示す肝炎医療コーディネーターの役割を果たしているか不明であった。今回、認定者全員に調査票を郵送して、認定から現在までの肝炎に関する活動状況を調査した。地域肝炎対策サポーター298人中146人から回答を得た。回答者の56%が肝疾患関連部署に引き続き勤務し、3割が厚生労働省の示す肝炎医療コーディネーターの役割に合致することを確認した。回答者の24%は他部署へ異動していたが、その56%が日常業務と別に肝炎医療コーディネーター活動を行っており、部署の異動は非専門診療科に肝炎医療コーディネーター活動のできる人材を拡げる良い機会と考えられる。肝炎医療コーディネーターは医療圏の間で偏在を認めなかった。(著者抄録)

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Papers - TAKAKI Akinobu