Faculty Profiles - SUGAYA AKIKO

Papers - SUGAYA AKIKO

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思春期から青年期の難聴者が持つ代償・補償スキルと知識に関する一考察

中川敦子, 片岡祐子, 田中里実, 細川夏実, 菅谷明子, 假谷伸

Audiology Japan 64 ( 5 ) 389 - 389 2021.9

Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss. Reviewed

Yuko Kataoka, Yukihide Maeda, Akiko Sugaya, Ryotaro Omichi, Shin Kariya

Acta medica Okayama 75 ( 4 ) 511 - 516 2021.8

Language：English Publishing type：Research paper (scientific journal)

WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.

DOI： 10.18926/AMO/62404

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Immediate changes in transcription factors and synaptic transmission in the cochlea following acoustic trauma: A gene transcriptome study. Reviewed International journal

Yukihide Maeda, Shin Kariya, Kensuke Uraguchi, Junko Takahara, Shohei Fujimoto, Akiko Sugaya, Kazunori Nishizaki

Neuroscience research 165 6 - 13 2021.4

Language：English Publishing type：Research paper (scientific journal)

Pathologic mechanisms in cochleae immediately following the onset of noise-induced hearing loss (NIHL) remain unclear. In this study, mice were exposed to 120 dB of octave band noise for 2 h to induce NIHL. Three hours after noise exposure, expression levels of the whole mouse genome in cochleae were analyzed by RNA-seq and DNA microarray. Differentially expressed genes (DEGs) exhibiting >2-fold upregulation or downregulation in noise-exposed cochleae compared to controls without noise exposure were identified. RNA-seq and microarray analyses identified 273 DEGs regulated at 3 h post-noise (51 upregulated and 222 downregulated). Bioinformatic analysis revealed that these DEGs were associated with the functional gene pathway "neuroactive ligand-receptor interaction" and included 28 genes encoding receptors for neurotransmitters such as gamma-aminobutyric acid and glutamate. Other DEGs included 25 genes encoding transcription factors. Downregulation of 4 neurotransmitter receptors (Gabra3, Gabra5, Gabrb1, Grm1) and upregulations of 5 transcription factors (Atf3, Dbp, Helt, Maff, Nr1d1) were validated by RT-PCR. The differentially regulated transcription factor Atf3 immunolocalized to supporting cells and hair cells in the organ of Corti at 12-h post-noise. The present data serve as a basis for further studies aimed at developing medical treatments for acute sensorineural hearing loss.

DOI： 10.1016/j.neures.2020.05.001

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Fertility Preservation Therapy Provided for Childhood, Adolescent, and Young Adult Cancer Patients —Current Status and Efforts to Improvement—,小児，思春期・若年がん患者に対する妊孕性温存療法―現状と改善の取り組み―

Akisada, N., Makino, T., Sugaya, A., Kataoka, Y., Ando, M., Monden, N., Nakatsuka, M.

Practica Oto-Rhino-Laryngologica 114 ( 12 ) 2021

Prevalence and risk factors for delayed-onset hearing loss in early childhood: A population-based observational study in Okayama Prefecture, Japan. Reviewed International journal

Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Akiko Shigehara, Shin Kariya, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 138 110298 - 110298 2020.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: The aim of this study was to retrospectively document prevalence rates of delayed-onset hearing loss (DOHL) under 7 years old after passing the newborn hearing screening (NHS) program using its database in Okayama Prefecture, as well as records from Okayama Kanariya Gakuen (OKG, Auditory Center for Hearing Impaired Children, Okayama Prefecture, Japan). We explored the percentage of children with DOHL among all children who underwent the NHS and surveyed risk factors abstracted from their clinical records. METHODS: We collected data of 1171 children, who first visited OKG from April 2006 to March 2018. DOHL children were defined as bilaterally hearing-impaired children who were diagnosed under 7 years old after passing the NHS at birth. Based on the medical records, we investigated age at diagnosis, hearing levels, and risk factors. As population-based data of 168,104 children, the percentage of DOHL subjects was retrospectively calculated among the total number of children who underwent the NHS in Okayama Prefecture from April 2005 to March 2017. RESULTS: During the period, we identified 96 children with bilateral DOHL, of which 34 children had failed the NHS unilaterally and 62 had passed the NHS bilaterally. Among all children who underwent the NHS in Okayama Prefecture, the prevalence rate of DOHL in unilaterally referred infants was 5.2%, and 0.037% in bilaterally passed children. The prevalence of bilateral DOHL was 0.057% overall. Unilaterally referred children with DOHL were diagnosed at an average of 13.9 months, while bilaterally passed children with DOHL were diagnosed at an average of 42.3 months. Approximately 59.4% of children with DOHL had risk factors, among which family history of hearing loss was the most frequent. CONCLUSION: We propose the first English report of DOHL prevalence in the prefecture population in Japann, which is among the largest community-based population ever reported. The NHS is not a perfect strategy to detect all early-childhood hearing loss; therefore, careful assessment of hearing throughout childhood is recommended, especially in children with risk factors of hearing loss. Further interventional strategies must be established, such as regular hearing screening in high-risk children and assessments of hearing and speech/language development in public communities and nursery schools.

DOI： 10.1016/j.ijporl.2020.110298

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Progression of hearing loss and choice of hearing aids by patients in their 60s, 70s, and 80s and older: experience in the Japanese super-aged era. Reviewed

Maeda Y, Kariya S, Fujimoto S, Sugaya A, Kataoka Y, Nakagawa A, Tanaka S, Hosokawa N, Nishizaki K.

Acta Otolaryngol 139 1077 - 1082 2019.9

Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. Reviewed

Sugaya A, Fukushima K, Takao S, Kasai N, Maeda Y, Fujiyoshi A, Kataoka Y, Kariya S, Nishizaki K.

Int J Pediatr Otorhinolaryngol 126 109619 - 109619 2019.8

Targeted PCR Array Analysis of Genes in Innate Immunity and Glucocorticoid Signaling Pathways in Mice Cochleae Following Acoustic Trauma. Reviewed International journal

Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Yohei Noda, Akiko Sugaya, Shohei Fujimoto, Kazunori Nishizaki

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 39 ( 7 ) e593 - e600 2018

Language：English Publishing type：Research paper (scientific journal)

AIM: To comprehensively analyze cochlear gene expressions related to innate immunity and glucocorticoid signaling at onset of acute noise-induced hearing loss (NIHL). BACKGROUND: Recent studies suggested innate immunity is involved in the cochlear pathology of NIHL. Glucocorticoids may modulate immune actions in cochleae. METHODS: Mice were exposed to 120 dB-octave band noise for 2 hours. Twelve hours later, a targeted PCR array analyzed cochlear expressions of 84 key genes in inflammation and immune pathways and 84 genes in the glucocorticoid signaling pathway. Real-time RT-PCR was used to analyze expression of two immune-related genes, Ccl12 and Glycam1, in noise-exposed cochleae with or without dexamethasone. RESULT: In inflammatory and immune gene pathways, 31.0% (26/84 genes) were significantly upregulated (>2-fold change) or downregulated (<0.5-fold change) (p < 0.05) in noise-exposed cochleae compared with controls. Sixteen of these differentially expressed genes (DEGs) encoded chemokines. DEGs included Ccl12, Ccl2, Ccl4, Ccl7, Cxcl1, Cxcl10, and Ptgs2 (upregulated genes), and Ccr7, Cxcr2, Kng1, Ltb, and Tnfsf14 (downregulated genes). In the glucocorticoid signaling pathway, 92.9% (78/84 genes) were unchanged in noise-exposed cochleae without dexamethasone administration. Cochlear expressions of Ccl12 and Glycam1 were significantly upregulated by noise and downregulated by dexamethasone. CONCLUSION: The targeted PCR array demonstrated that several dozen genes involved in innate immunity are actively regulated in cochleae with NIHL. The glucocorticoid signaling pathway was not endogenously regulated at 12 hours post-noise trauma. Systemic dexamethasone downregulated Ccl12 and Glycam1, which are upregulated in noise-exposed cochleae. These data may provide a basis for genomic medicine treatment of acute sensorineural hearing loss.

DOI： 10.1097/MAO.0000000000001874

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WFS1 mutation screening in a large series of Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis. Reviewed International journal

Masafumi Kobayashi, Maiko Miyagawa, Shin-Ya Nishio, Hideaki Moteki, Taro Fujikawa, Kenji Ohyama, Hirofumi Sakaguchi, Ikuyo Miyanohara, Akiko Sugaya, Yasushi Naito, Shin-Ya Morita, Yukihiko Kanda, Masahiro Takahashi, Kotaro Ishikawa, Yuki Nagano, Tetsuya Tono, Chie Oshikawa, Chiharu Kihara, Haruo Takahashi, Yoshihiro Noguchi, Shin-Ichi Usami

PloS one 13 ( 3 ) e0193359 2018

Language：English Publishing type：Research paper (scientific journal)

A heterozygous mutation in the Wolfram syndrome type 1 gene (WFS1) causes autosomal dominant nonsyndromic hereditary hearing loss, DFNA6/14/38, or Wolfram-like syndrome. To date, more than 40 different mutations have been reported to be responsible for DFNA6/14/38. In the present study, WFS1 variants were screened in a large series of Japanese hearing loss (HL) patients to clarify the prevalence and clinical characteristics of DFNA6/14/38 and Wolfram-like syndrome. Massively parallel DNA sequencing of 68 target genes was performed in 2,549 unrelated Japanese HL patients to identify genomic variations responsible for HL. The detailed clinical features in patients with WFS1 variants were collected from medical charts and analyzed. We successfully identified 13 WFS1 variants in 19 probands: eight of the 13 variants were previously reported mutations, including three mutations (p.A684V, p.K836N, and p.E864K) known to cause Wolfram-like syndrome, and five were novel mutations. Variants were detected in 15 probands (2.5%) in 602 families with presumably autosomal dominant or mitochondrial HL, and in four probands (0.7%) in 559 sporadic cases; however, no variants were detected in the other 1,388 probands with autosomal recessive or unknown family history. Among the 30 individuals possessing variants, marked variations were observed in the onset of HL as well as in the presence of progressive HL and tinnitus. Vestibular symptoms, which had been rarely reported, were present in 7 out of 30 (23%) of the affected individuals. The most prevalent audiometric configuration was low-frequency type; however, some individuals had high-frequency HL. Haplotype analysis in three mutations (p.A716T, p.K836T, and p.E864K) suggested that the mutations occurred at these mutation hot spots. The present study provided new insights into the audiovestibular phenotypes in patients with WFS1 mutations.

DOI： 10.1371/journal.pone.0193359

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Relationship between pure-tone audiogram findings and speech perception among older Japanese persons. Reviewed International journal

Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

Acta oto-laryngologica 138 ( 2 ) 140 - 144 2018

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. METHODS: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson's correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. RESULTS: SP correlated well (r = -0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = -0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). CONCLUSION: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

DOI： 10.1080/00016489.2017.1378435

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次世代シークエンサー(NGS)を併用した難聴遺伝子検査が有用であった3症例

菅谷明子, 片岡祐子, 前田幸英, 假谷伸, 大道亮太郎, 峠和美, 佐藤吏江, 西崎和則

日本遺伝カウンセリング学会誌 38 ( 2 ) 120 - 120 2017.5

中耳炎により外科的処置を要した小児人工内耳装用例の検討

片岡祐子, 假谷伸, 菅谷明子, 大道亮太郎, 福島邦博, 西崎和則

小児耳鼻咽喉科 38 ( 2 ) 153 - 153 2017.5

新生児聴覚スクリーニング実施における費用対効果の検討

片岡祐子, 菅谷明子, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 4 ) 588 - 588 2017.4

Cochlear Transcriptome Following Acoustic Trauma and Dexamethasone Administration Identified by a Combination of RNA-seq and DNA Microarray. Reviewed International journal

Yukihide Maeda, Ryotaro Omichi, Akiko Sugaya, Shin Kariya, Kazunori Nishizaki

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 38 ( 7 ) 1032 - 1042 2017

Language：English Publishing type：Research paper (scientific journal)

AIM: To elucidate molecular mechanisms of noise-induced hearing loss (NIHL) and glucocorticoid therapy in the cochlea. BACKGROUND: Glucocorticoids are used to treat many forms of acute sensorineural hearing loss, but their molecular action in the cochlea remains poorly understood. METHODS: Dexamethasone was administered intraperitoneally immediately following acoustic overstimulation at 120 dB SPL for 2 hours to mice. The whole cochlear transcriptome was analyzed 12 and 24 hours following noise trauma and dexamethasone administration by both next-generation sequencing (RNA-seq) and DNA microarray. Differentially expressed genes (DEGs) with more than 2-fold changes after noise trauma and dexamethasone administration were identified. The functions of these DEGs were analyzed by David Bioinformatics Resources and a literature search. RESULTS: Twelve hours after acoustic overstimulation, immune-related gene pathways such as "chemokine signaling activity," "cytokine-cytokine receptor interaction," and "cell adhesion molecules (CAMs) in the immune system" were significantly changed compared with the baseline level without noise. These DEGs were involved in immune and defense responses in the cochlea. Dexamethasone was administered to this NIHL model, and it modulated gene pathways of "cytokine-cytokine receptor interaction" and "cell adhesion molecules (CAMs) in the immune system" at 12 hours, compared with saline-injected control. Dexamethasone-dependent DEGs were also involved in immune and defense responses. A literature search showed that 10 other genes associated with hearing functions were regulated by dexamethasone both at 12 and 24 hours post-administration. CONCLUSION: Dexamethasone modulates the immune reaction in the traumatized cochlea following acoustic overstimulation. Dexamethasone may also regulate cochlear functions other than immunity.

DOI： 10.1097/MAO.0000000000001373

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Genetic counseling of a hearing-impaired patient with multiple genetic mutations Reviewed

Yuko Kataoka, Akiko Sugaya, Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Kunihiro Fukushima, Kazunori Nishizaki

Journal of Otolaryngology of Japan 120 ( 2 ) 131 - 136 2017

Reversal of the inner magnet of a cochlear implant after magnet resonance imaging Reviewed

Yuko Kataoka, Tomoyuki Naito, Shin Kariya, Akiko Sugaya, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

Journal of Otolaryngology of Japan 120 ( 5 ) 727 - 732 2017

Pediatric central auditory processing disorder showing elevated threshold on pure tone audiogram Reviewed

Yukihide Maeda, Atsuko Nakagawa, Rie Nagayasu, Akiko Sugaya, Ryotaro Omichi, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

AURIS NASUS LARYNX 43 ( 5 ) 570 - 574 2016.10

Subjective hearing-related quality-of-life is a major factor in the decision to continue using hearing aids among older persons Reviewed

Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

ACTA OTO-LARYNGOLOGICA 136 ( 9 ) 919 - 922 2016.9

MRI検査後に人工内耳インプラントのマグネットの反転を来たした2例

内藤智之, 片岡祐子, 假谷伸, 菅谷明子, 大道亮太郎, 前田幸英, 西崎和則

Otology Japan 26 ( 4 ) 570 - 570 2016.9

急性感音難聴モデルマウスへのステロイド投与後の内耳遺伝子発現 RNA-seqとDNAマイクロアレイを用いた解析

前田幸英, 大道亮太郎, 菅谷明子, 片岡祐子, 假谷伸, 西崎和則

Otology Japan 26 ( 4 ) 489 - 489 2016.9

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Papers - SUGAYA AKIKO