Faculty Profiles - MORITA Hiroshi

Papers - MORITA Hiroshi

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カテーテルアブレーション後,右室内にExit Blockを生じた不整脈源性右室異形成症の1例

草野研吾, 森田宏, 江森哲郎, 垣下幹夫, 物部秀明, 藤本良久, 伴場主一, 谷山真規子, 中山和昭, 松原広己, 山成洋, 大江透

臨床心臓電気生理 23 113 - 120 2000.5

Language：Japanese Publisher：臨床心臓電気生理研究会

46歳女.以前より不整脈源性右室異形成症としてfollowされており,昼食後に突然動悸が出現した.心室頻拍(VT)は190/分で,電気生理学的検査では,右室のbaseから心尖部の下壁の広い範囲に,心電図上のイプシロン波に一致する大きなdelayed potential(DP)を伴う異常電位が認められた.このDPの認められる部位からのペーシングによって全てVTとほぼ同波形のQRS波形が得られた.VTに対するアブレーションは回路のexit siteに近いと考えられたmid free wallの通電によって行い,以後誘発不能となった.その後,DPの記録される部位からペーシングを行ったところ,ペーシングによってDPは捕捉されたが,体表面心電図のQRS波とは解離を示した

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Involvement of Ca^<2+> in Antiarrhythmic Effect of Ischemic Preconditioning in Isolated Rat Heart

HONG Kui, FUKUSHIMA-KUSANO Kengo, MORITA Hiroshi, FUJIMOTO Yoshihisa, NAKAMURA Kazufumi, YAMANARI Hiroshi, OHE Tohru

The Journal of Physiological Sciences 50 ( 2 ) 207 - 213 2000.4

Language：English Publisher：PHYSIOLOGICAL SOCIETY OF JAPAN

We investigated the relationship between the effects of ischemic preconditioning (IPC) and Ca²⁺ preconditioning (CPC) on reperfusion-induced arrhythmias. In the control group (noPC), Langendorff-perfused rat hearts were subjected to 5-min zero-flow global ischemia (I) followed by 15-min reperfusion (I/R). In ischemic preconditioning groups (IPC), the hearts were subjected to three cycles of 3-min global ischemia and 5-min reperfusion. In the CPC group, the hearts were exposed to three cycles of 3-min perfusion of higher Ca²⁺ (2.3 mmol/l Ca²⁺) followed by 5-min perfusion of normal 1.3 mmol/l Ca²⁺, and the hearts were then subjected to I/R. Verapamil was administered in several hearts of the IPC group (VR+IPC). Ventricular arrhythmias upon reperfusion were less frequently seen in the IPC and CPC groups than in the noPC and VR+IPC groups. IPC and CPC could attenuate conduction delay and enhance shortening of the monophasic action potential duration during ischemia. The ventricular fibrillation threshold measured at 1-min reperfusion was significantly higher in the IPC and CPC groups than in the noPC and VR+IPC groups. Verapamil completely abolished the salutary effects of IPC. These results demonstrate that Ca²⁺ plays an important role in the antiarrhythmic effect of IPC during reperfusion.<br>

DOI： 10.2170/jjphysiol.50.207

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Other Link： https://jlc.jst.go.jp/DN/JALC/00089129272?from=CiNii

無症候性Brugada型心電図波形を呈する症例についての検討

大田恵子, 竹中志保, 永瀬聡, 森田宏, 草野研吾, 松原広己, 山成洋, 大江透

日本内科学会雑誌 89 ( 臨増 ) 126 - 126 2000.2

Successful catheter ablation in a patient with polymorphic ventricular tachycardia

Kengo Fukushima Kusano, Mika Yamamoto, Tetsuro Emori, Hiroshi Morita, Tohru Ohe

Journal of Cardiovascular Electrophysiology 11 ( 6 ) 682 - 685 2000

Language：English Publishing type：Research paper (scientific journal) Publisher：Futura Publishing Company Inc.

We describe a patient with polymorphic ventricular tachycardia (PVT)/ventricular fibrillation (VF) without organic heart disease who was cured by radiofrequency catheter ablation. The patient was a 65-year-old woman with a 10-year history of recurrent syncope. There was no evidence of organic heart disease, and the QT interval during sinus rhythm was borderline normal (corrected QT interval = 0.45 sec(1/2)). ECG recording during syncope showed PVT. On one occasion, PVT degenerated into VF. This PVT was always induced by a premature ventricular complex (PVC) originating from the right ventricular (RV) outflow tract. Rapid pacing (220 beats/min) at the site of PVC origin reproduced polymorphic change of the QRS wave on surface ECG that was similar to PVT. This suggests that the PVT originated from a single focus in the RV outflow tract. Catheter ablation was performed at the site of PVC origin. During 18-month follow-up, PVT/VF was not documented.

DOI： 10.1111/j.1540-8167.2000.tb00031.x

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Attenuation of conduction delay by ischemic preconditioning reduces ischemia-induced ventricular arrhythmias.

Hong Kui, Kusano Kengo Fukushima, Morita Hiroshi, Fujimoto Yoshihisa, Wang Xian, Yamanari Hiroshi, Ohe Tohru

Acta Medica Okayama 53 ( 5 ) 233 - 238 1999.10

類似したwide QRS tachycardia波形を認めた特殊な頻拍の2症例

森田宏, 福島研吾[草野], 藤本良久, 垣下幹夫, 江森哲朗, 山成洋, 大江透

心電図 19 ( 5 ) 610 - 610 1999.8

心室再分極過程alternans現象に及ぼすNicorandilの影響動物実験及び臨床例からの検討

藤本良久, 草野研吾, 森田宏, 垣下幹夫, 山成洋, 大江透

心電図 19 ( 5 ) 529 - 529 1999.8

Evaluation of Autonomic Nervous Activity in Patients With Congenital Long QT Syndrome by an Analysis of RR Variability

MORITA Hiroshi, YAMANARI Hiroshi, OHE Tohru

Circulation Journal 60 ( 10 ) 742 - 748 1996.9

Language：English Publisher：Japanese Circulation Society

Congenital long QT syndrome (LQTS) is a rare hereditary disease characterized by a prolonged QT interval and lethal ventricular tachycardia (Torsades de Pointes: TdP). The pathogenesis of LQTS and the induction of TdP have been thought to be closely related to autonomic nervous abnormalities. We examined autonomic activity in 13 LQTS patients by analyzing heart rate variability from 24 h Holter ambulatory electrocardiographic recordings without medications. In a frequency-analysis of RR variability, we calculated the power in the low-frequency domain (LF) and the high-frequency domain (HF) over 24 h. The ratio of LF to HF (an index of sympathetic nervous activity) was lower in LQTS patients than in controls, whereas HF (an index of parasympathetic nervous activity) was higher. Moreover, LQTS patients with TdP had lower abnormal sympathetic nervous activity than those without TdP. The index of autonomic nervous activity obtained using this method could be useful for evaluating the severity in LQTS. (Jpn Circ J 1996; 60: 742 - 748)

DOI： 10.1253/jcj.60.742

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Other Link： http://search.jamas.or.jp/link/ui/1997084639

Early Afterdepolarization Abolished by Potassium Channel Opener in a Patient with Idiopathic Long QT Syndrome

TETSUYA SATO, YOSHIKI HATA, MIKA YAMAMOTO, HIROSHI MORITA, KOZO MIZUO, HIROSHI YAMANARI, DAIJI SAITO, TOHRU OHE

Journal of Cardiovascular Electrophysiology 6 ( 4 ) 279 - 282 1995

Language：English Publishing type：Research paper (scientific journal)

Abolished Early Afterdepolarization by Nicorandil. We describe a 17‐year‐old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased KAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener. Copyright © 1995, Wiley Blackwell. All rights reserved

DOI： 10.1111/j.1540-8167.1995.tb00400.x

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