Updated on 2026/08/22

写真a

 
Kageyama Lisa
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • PhD ( 2025.3   Tohoku University )

Research Interests

  • 分光分析

  • 液–液相分離

Research History

  • Okayama University   学術研究院医歯薬学域

    2026.4

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  • Tohoku University   Graduate School of Pharmaceutical Sciences

    2025.4 - 2026.3

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Professional Memberships

 

Papers

  • Liquid–liquid phase separation-assisted Raman microscopy for sensitive and label-free analysis of enzymatic reactions and protein–small molecule interactions Reviewed

    Lisa Kageyama, Shinya Tahara, Reona Tobita, Shinji Kajimoto, Takakazu Nakabayashi

    The Analyst   2026

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/D5AN00973A

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  • Raman quantitative analysis of methionine oxidation and its promotion effect on dissolution of phase-separated liquid droplets of Pbp1 Reviewed

    Lisa Kageyama, Shinya Tahara, Kohei Yokosawa, Mana Kamijo, Shinji Kajimoto, Takakazu Nakabayashi

    Chemical Physics Letters   856   141671 - 141671   2024.12

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.cplett.2024.141671

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  • Establishment of a Method for the Introduction of Poorly Water-Soluble Drugs in Cells and Evaluation of Intracellular Concentration Distribution Using Resonance Raman Imaging Reviewed

    Keisuke Koga, Shinji Kajimoto, Yuta Yoshizaki, Hiroaki Takahashi, Lisa Kageyama, Tomohiro Konno, Takakazu Nakabayashi

    The Journal of Physical Chemistry B   128 ( 6 )   1350 - 1359   2024.1

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    Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acs.jpcb.3c06601

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  • Highly sensitive Raman measurements of protein aqueous solutions using liquid–liquid phase separation Reviewed

    Reona Tobita, Lisa Kageyama, Ayaka Saito, Shinya Tahara, Shinji Kajimoto, Takakazu Nakabayashi

    Chemical Communications   60 ( 66 )   8732 - 8735   2024

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry (RSC)  

    A highly sensitive method is proposed for obtaining the Raman spectra of low-concentration proteins and nucleic acids in an aqueous solution using liquid–liquid phase separation.

    DOI： 10.1039/d4cc03035d

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  • Supersulphides provide airway protection in viral and chronic lung diseases Reviewed

    Tetsuro Matsunaga, Hirohito Sano, Katsuya Takita, Masanobu Morita, Shun Yamanaka, Tomohiro Ichikawa, Tadahisa Numakura, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Sunghyeon Yoon, Naoya Fujino, Yorihiko Kyogoku, Yusaku Sasaki, Akira Koarai, Tsutomu Tamada, Atsuhiko Toyama, Takakazu Nakabayashi, Lisa Kageyama, Shigeru Kyuwa, Kenji Inaba, Satoshi Watanabe, Péter Nagy, Tomohiro Sawa, Hiroyuki Oshiumi, Masakazu Ichinose, Mitsuhiro Yamada, Hisatoshi Sugiura, Fan-Yan Wei, Hozumi Motohashi, Takaaki Akaike

    Nature Communications   14 ( 1 )   2023.7

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here, we identify protective functions of supersulphides in viral airway infections (influenza and COVID-19), in aged lungs and in chronic lung diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF). We develop a method for breath supersulphur-omics and demonstrate that levels of exhaled supersulphides increase in people with COVID-19 infection and in a hamster model of SARS-CoV-2 infection. Lung damage and subsequent lethality that result from oxidative stress and inflammation in mouse models of COPD, IPF, and ageing were mitigated by endogenous supersulphides production by CARS2/CPERS or exogenous administration of the supersulphide donor glutathione trisulphide. We revealed a protective role of supersulphides in airways with various viral or chronic insults and demonstrated the potential of targeting supersulphides in lung disease.

    DOI： 10.1038/s41467-023-40182-4

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    Other Link： https://www.nature.com/articles/s41467-023-40182-4

  • Potential role of serotonin as a biological reductant associated with copper transportation Reviewed

    Kaede Saito, Kasumi Watanabe, Risa Yanaoka, Lisa Kageyama, Takashi Miura

    Journal of Inorganic Biochemistry   199   110770 - 110770   2019.10

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    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jinorgbio.2019.110770

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Books

  • 量子化学計算・ラマン分光法を用いた硫黄化合物の構造解析の動向

    影山 莉沙, 中林 孝和

    2021.10 

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  • 量子化学でひもとく超硫黄分子の構造と反応性

    影山莉沙, 中林孝和

    2021.8 

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Presentations

  • 液－液相分離現象を利用した高感度ラマン測定法の開発と生体分子構造の定量解析 Invited

    影山莉沙

    日本薬学会東北支部若手セミナー  2026.1.17 

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  • 液滴濃縮による新規高感度ラマン測定法の提案

    影山莉沙

    新興硫黄生物学が拓く生命原理変革（硫黄生物学） 第 5 回領域会議  2026.1.14 

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  • 液-液相分離を用いた生体分子の高感度ラマン観測法の開発とタンパク質の超硫黄化のその場検出

    影山莉沙

    新興硫黄生物学が拓く生命原理変革（硫黄生物学） 第 5 回領域会議  2026.1.13 

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  • High-sensitivity Raman spectroscopy by droplet concentration: Application to detection of biomolecules at the μM level and visualization of reactions

    2025.9 

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  • ラマン顕微鏡を用いた超硫黄化タンパク質の非破壊的測定法の確立および構造-機能相関の解明

    影山莉沙, 田原進也, 梶本真司, 中林孝和

    2023.3 

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  • Raman analyses of supersulfides and S8 in vitro and in human living cells

    影山莉沙, 梶本真司, 田原進也, 中林孝和

    第60回日本生物物理学会  2022.9 

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  • Theoretical study on the structure and reactivity of persulfides :importance in biology

    影山莉沙, 中林孝和

    化学系協会東北支部大会  2021.10.3 

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  • 量子化学計算を用いたパースルフィドの構造解析と反応性の検討

    影山莉沙, 中林孝和

    第15回分子科学討論会  2021.9.19 

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Awards

  • BCSJ award

    2025.9   分子科学   第19回分子科学会討論会 口頭発表

    影山莉沙

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  • 優秀講演賞

    2025.9   分子科学会   第19回分子科学会討論会 口頭発表

    影山莉沙

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Research Projects

  • ラマン・ブリリアン顕微鏡による細胞老化における水分動態と形態機能変化の統合的解析

    Grant number：25K23577  2025.07 - 2027.03

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

    影山 莉沙

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    Grant amount：\2730000 （ Direct expense: \2100000 、 Indirect expense：\630000 ）

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  • ラマンブリルアンイメージを用いた老化細胞核内の水密度の解析

    2025.04 - 2026.03

    東北大学  スタートアップ研究費（TUMUG 支援プログラム） 

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    Authorship：Principal investigator 

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