Updated on 2025/02/19

写真a

 
Omokawa Marina
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • Doctor of Pharmacy ( 2024.3   Kyoto Pharmaceutical University )

Education

  • Kyoto Pharmaceutical University   大学院薬学研究科   薬学専攻博士課程

    2020.4 - 2024.3

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  • Kyoto Pharmaceutical University   薬学部   薬学科

    2014.4 - 2020.3

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Research History

  • Kanazawa University   疾患モデル総合センター 疾患解析プローブ・ケミカル分野

    2024.4

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  • Okayama University   学術研究院医歯薬学域 産学官連携センター

    2024.4

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Professional Memberships

 

Papers

  • Theranostics using 89Zr/177Lu-labeled antibody targeting erythropoietin-producing hepatocellular A2 (EphA2)

    Tadashi Watabe, Takumi Iwasawa, Hiroyuki Kimura, Yoshifumi Shirakami, Sadahiro Naka, Kazuko Kaneda, Takanori Kobayashi, Marina Omokawa, Yusuke Yagi, Noriyuki Tomiyama, Kazunori Kato

    European Journal of Nuclear Medicine and Molecular Imaging   2025.2

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    Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Purpose

    Erythropoietin-producing hepatocellular A2 (EphA2) is abundantly expressed in various types of cancers. This study aimed to assess the therapeutic effect of 177Lu-labeled EphA2 antibody in combination with PET imaging using 89Zr-labeled antibody.

    Methods

    An EphA2 monoclonal antibody (mAb) (clone 230-1) was labeled with 89Zr and 177Lu using DFO and NOTA chelators, respectively. HT-1080 (EphA2-expressing human fibrosarcoma) xenograft mice were intravenously administered [89Zr]Zr-EphA2 mAb (n = 6) for PET scanning, and [177Lu]Lu-EphA2 mAb (n = 12) to evaluate the biodistribution and specificity of uptake in HT-1080 xenografts in a blocking study. The antitumor effect was evaluated by administering 10 (n = 9) or 3MBq (n = 9) of [177Lu]Lu-EphA2 mAb, non-radiolabeled EphA2 mAb (n = 6), [177Lu]LuCl3 solution (10MBq, n = 6), or saline solution (control, n = 4) to HT-1080 xenograft mice. Body weight monitoring and preliminary blood tests were performed to evaluate toxicity. Immunohistochemical staining for EphA2 was performed using HT-1080 xenografts.

    Results

    On [89Zr]Zr-EphA2 mAb PET, a markedly high accumulation was observed in the tumor xenograft 1 day after administration (SUVmax, 11.8 ± 4.98), which increased on day 5 (SUVmax, 20.1 ± 6.42). [177Lu]Lu-EphA2 mAb exhibited excellent uptake and retention in HT-1080 xenografts (49.4 ± 10.8%IA/g at 24 h and 101.8 ± 26.3%IA/g at 72 h after administration). Normal organs did not show high physiological uptake, except for the blood (16.9 ± 0.43%IA/g at 24 h and 16.1 ± 4.9%IA/g at 72 h). The blocking study demonstrated a significant reduction of tumor uptake 24 h after administration (47.2 ± 8.22 vs. 10.7 ± 0.52%IA/g, P = 0.02). Substantial tumor growth inhibition, and complete remission without severe toxicity (6 of 18 mice), was observed in HT-1080 xenograft mice after [177Lu]Lu-EphA2 mAb (3 and 10 MBq) administration. The non-radiolabeled EphA2 mAb showed a minor treatment effect compared with [177Lu]Lu-EphA2 mAb. Immunohistochemical staining revealed high EphA2 expression in the HT-1080 xenografts.

    Conclusion

    [89Zr]Zr-/[177Lu]Lu-EphA2 mAb demonstrated high retention in tumors, and [177Lu]Lu-EphA2 mAb exhibited marked tumor shrinkage. EphA2 is a promising theranostics target for potential application in various types of cancer.

    DOI： 10.1007/s00259-025-07139-9

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    Other Link： https://link.springer.com/article/10.1007/s00259-025-07139-9/fulltext.html

  • Production and synthesis of a novel 191Pt-labeled platinum complex and evaluation of its biodistribution in healthy mice Reviewed

    Marina Omokawa, Hiroyuki Kimura, Yuichi Hatsukawa, Hidekazu Kawashima, Kazuaki Tsukada, Yusuke Yagi, Yuki Naito, Hiroyuki Yasui

    Bioorganic & Medicinal Chemistry   97   117557   2024.1

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.bmc.2023.117557

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  • Synthesis and Biological Evaluation of a Novel Sugar-Conjugated Platinum(II) Complex Having a Tumor-Targeting Effect Reviewed

    Marina Omokawa, Hiroyuki Kimura, Kenji Arimitsu, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Yuki Naito, Hiroyuki Yasui

    ACS Omega   9 ( 1 )   879 - 886   2023.12

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    DOI： 10.1021/acsomega.3c06922

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MISC

  • Synthesis and biological evaluation of a novel sugar-conjugated platinum complex having a tumor-targeting effect and 191Pt labeled complex

    面川真里奈, 木村寛之, 木村寛之, 初川雄一, 河嶋秀和, 塚田和明, 屋木裕亮, 内藤行喜, 安井裕之

    日本薬学会年会要旨集(Web)   144th   2024

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  • Evaluation of biodistribution of a novel sugar-conjugated platinum complex and its complex labeled with 191Pt in mice

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    日本薬学会年会要旨集(Web)   143rd   2023

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  • Development of antitumor agent using glucose-conjugated novel platinum complexes

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    日本薬学会年会要旨集(Web)   142nd   2022

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  • Synthesis of a glucose-conjugated novel platinum complex labeled with 191Pt and evaluation of its drug characteristics

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    アイソトープ・放射線研究発表会(Web)   59th   2022

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  • Synthesis of cancer theranostic probe by sugar-linked platinum complex

    OMOKAWA Marina, ARIMITSU Kenji, YAGI Yusuke, NAITO Yuki, YASUI Hiroyuki, KIMURA Hiroyuki

    金属の関与する生体関連反応シンポジウム講演要旨集   29th   2019

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Presentations

  • Synthesis and Evaluation of CYP11B2 selective PAY derivatives for Primary Aldosteronism Imaging

    Yagi Y, Kimura H, Fuseda R, Murakami T, Omokawa M, Kise S, Sone M, Saji H

    European Association of Nuclear Medicine, 37rd Annual EANM Congress  2024.10 

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    Event date： 2024.10.19 - 2024.10.23

    Language：English   Presentation type：Oral presentation (general)  

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  • Creation and biological evaluation of a novel sugar-platinum complex for cancer therapy

    The 33rd Symposium on Role of Metals in Biological Reactions, Biology and Medicine (SRM2024)  2024.6.7 

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    Event date： 2024.6.7 - 2024.6.8

    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Development of SPECT imaging probe with 111In-labeled anti-erythropoietinproducing hepatocellular A2 receptor antibody

    Hiroyuki Kimura, Marina Omokawa, Satoko Kise, Takumi Iwasawa, Kazunori Kato

    The 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences (CJKSRS2024)  2024.9 

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    Language：English   Presentation type：Poster presentation  

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  • Development of a novel sugar-conjugated platinum(II) complex having tumor growth inhibitory effect and a its 191Pt labeled complex for evaluation of its biodistribution

    Marina Omokawa, Hiroyuki Kimura, Yuichi Hatsukawa, Hidekazu Kawashima, Kazuaki tsukada, Yusuke Yagi, Yuki Naito, Hiroyuki Yasui

    The 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences (CJKSRS2024)  2024.9 

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    Language：English   Presentation type：Poster presentation  

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  • Application of radiopharmaceuticals using EphA2-targeted antibodies for diagnosis of pancreatic cancer

    Ryo Kunito, Hiroyuki Kimura, Marina Omokawa, Satoko Kise, Takumi Iwasawa, Kazunori Kato, Asuka Mizutani, Keiichi Kawai

    The 12th China-Japan-Korea Symposium on Radiopharmaceutical Sciences (CJKSRS2024)  2024.9 

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    Language：English   Presentation type：Poster presentation  

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  • 抗腫瘍効果を有する新規糖連結白金錯体と191Pt標識体の合成および生物学的評価

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 塚田和明, 屋木祐亮, 内藤行喜, 安井裕之

    日本薬学会第144年会  2024.3 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • Evaluation of biodistribution of a novel sugar-conjugated platinum complex labeled with 191Pt in mice

    Marina Omokawa, Hiroyuki Kimura, Yuichi Hatsukawa, Hidekazu Kawashima, Hiroyuki Yasui

    The 25th International Symposium of Radiopharmaceutical Sciences  2023.5 

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    Language：English   Presentation type：Poster presentation  

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  • 新規糖連結白金錯体と191Pt標識体のマウスにおける体内分布評価

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    日本薬学会第143年会  2023.3 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Synthesis and evaluation of a novel sugar conjugated platinum complex labeled with 191Pt

    Marina Omokawa, Hiroyuki Kimura, Yuichi Hatsukawa, Hidekazu Kawashima, Hiroyuki Yasui

    The 65th Radiobioassay & Radiochemical Measurements Conference  2022.11 

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    Language：English   Presentation type：Poster presentation  

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  • 191Pt標識白金錯体の合成とマウスにおける体内分布評価

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    第21回放射性医薬品・画像診断薬研究会  2022.9 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 新規糖連結白金錯体の191Pt標識体の合成と薬剤特性の評価

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    第59回 アイソトープ・放射線研究発表会  2022.7 

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    Language：Japanese   Presentation type：Oral presentation (general)  

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  • 新規糖連結白金錯体を用いたがん治療薬の開発

    面川真里奈, 木村寛之, 初川雄一, 河嶋秀和, 安井裕之

    日本薬学会第142年会  2022.3 

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    Language：Japanese   Presentation type：Poster presentation  

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  • Development of glucose-conjugated novel platinum complex having an antitumor activity

    Marina Omokawa, Hiroyuki Kimura, Kenji Arimitsu, Hiroyuki Yasui

    13th AFMC International Medicinal Chemistry Symposium  2021.11 

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    Language：English   Presentation type：Oral presentation (general)  

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  • 新規糖連結型配位子の白金錯体によるがん治療薬の開発

    面川真里奈, 木村寛之, 有光健治, 安井裕之

    第70回 日本薬学会関西支部大会  2020.10 

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    Presentation type：Oral presentation (general)  

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  • Synthesis of cancer theranostic probe by sugar-linked platinum complex

    Marina Omokawa, Kenji Arimitsu, Yusuke Yagi, Yuki Naito, Hiroyuki Yasui, Hiroyuki Kimura

    第29回金属の関与する生体関連反応シンポジウム  2019.5 

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    Language：English  

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Awards

  • 日本薬学会第 144 年会 学生優秀発表賞（口頭発表の部）

    2024.3  

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  • The 25th International Symposium of Radiopharmaceutical Sciences Student Travel Award

    2023.5  

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  • 日本薬学会第 143 年会 学生優秀発表賞（ポスター発表の部）

    2023.3  

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Research Projects

  • α線によるがん治療を目指した白金錯体結合型抗体薬剤の開発

    2025.04 - 2028.03

    公益財団法人放射線影響協会  令和6年度放射線影響研究奨励助成 

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    Authorship：Principal investigator 

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