Updated on 2025/05/01

写真a

 
KAMIOKA Hiroshi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
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Degree

  • 歯学博士 ( 徳島大学 )

Research Interests

  • メカニカルストレス

  • 歯の移動と骨改造

  • Tooth movement and bone remodeling

Research Areas

  • Life Science / Social dentistry

Education

  • The University of Tokushima    

    - 1993

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  • The University of Tokushima   歯学研究科   歯科矯正学

    - 1993

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    Country: Japan

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  • The University of Tokushima    

    - 1989

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  • The University of Tokushima   歯学部  

    - 1989

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    Country: Japan

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Research History

  • 岡山大学病院 教育(歯科)担当副病院長

    2023.4 - 2025.3

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  • 岡山大学 学術研究院 医歯薬学域 教授

    2021.4

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  • 広島大学歯学部   非常勤講師

    2021.4

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  • 岡山大学病院 教育・研究(歯科)担当副病院長

    2021.4 - 2023.3

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  • Dokkyo Medical University   口腔外科学講座

    2019.4

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Professional Memberships

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Committee Memberships

  • 中・四国矯正歯科学会   会長  

    2024.1   

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  • 日本矯正歯科学会   奨励論文賞選考委員会 委員長  

    2024.1   

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  • 日本矯正歯科学会   卒後教育委員会 委員長  

    2024.1   

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  • 日本骨形態計測学会   監事  

    2023.7   

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  • 東京歯科大学研究プロジェクト ウェルビーイングプロジェクト   外部評価委員会 委員長  

    2023.4   

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Papers

  • Clinical Prediction Models for Upper Airway Volume Based on Soft Palate and Airway Lumen Dimensions in Adults With Varying Vertical Skeletal Patterns

    Janvier Habumugisha, Sumire Ida, Masahiro Nakamura, Kana Kono, Kenta Uchida, Takumi Moriya, Megumi Konko, Satoru Hayano, Takashi Izawa, Hiroshi Kamioka

    International Dental Journal   2024.10

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.identj.2024.09.023

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  • 多様な顕微鏡を用いた,骨細胞ネットワーク形成におけるコラーゲン細線維集束の重要性の解明

    橋本 真奈, 高橋 春香, 田畑 香織, 長岡 紀幸, 原 徹, 飯村 忠浩, 上岡 寛

    日本骨形態計測学会雑誌   34 ( 2 )   68 - 69   2024.11

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    Language:Japanese   Publisher:日本骨形態計測学会  

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  • The cell membrane as biofunctional material for accelerated bone repair. Reviewed International journal

    Emi Hatano, Nahid Akhter, Risa Anada, Mitsuaki Ono, Toshitaka Oohashi, Takuo Kuboki, Hiroshi Kamioka, Masahiro Okada, Takuya Matsumoto, Emilio Satoshi Hara

    Acta biomaterialia   2024.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    The cell (plasma) membrane is enriched with numerous receptors, ligands, enzymes, and phospholipids that play important roles in cell-cell and cell-extracellular matrix interactions governing, for instance, tissue development and repair. We previously showed that plasma membrane nanofragments (PMNFs) act as nucleation sites for bone formation in vivo, and induce in vitro mineralization within 1 day. In this study, we optimized the methods for generating, isolating, and applying PMNFs as a cell-free therapeutic to expedite bone defect repair. The PMNFs were isolated from different mouse cell lines (chondrocytes, osteoblasts, and fibroblasts), pre-conditioned, lyophilized, and subsequently transplanted into 2 mm critical-sized calvarial defects in mice (n = 75). The PMNFs from chondrocytes, following a 3-day pre-incubation, significantly accelerated bone repair within 2 weeks, through a coordinated attraction of macrophages, endothelial cells, and osteoblasts to the healing site. In vitro experiments confirmed that PMNFs enhanced cell adhesion. Comparison of the PMNF efficacy with phosphatidylserine, amorphous calcium phosphate (ACP), and living cells confirmed the unique ability of PMNFs to promote accelerated bone repair. Importantly, PMNFs promoted nearly complete integration of the regenerated bone with native tissue after 6 weeks (% non-integrated bone area = 15.02), contrasting with the partial integration (% non-integrated bone area = 56.10; p < 0.01, Student's test) with transplantation of ACP. Vickers microhardness tests demonstrated that the regenerated bone after 6 weeks (30.10 ± 1.75) exhibited hardness similar to native bone (31.07 ± 2.46). In conclusion, this is the first study to demonstrate that cell membrane can be a promising cell-free material with multifaceted biofunctional properties that promote accelerated bone repair. STATEMENT OF SIGNIFICANCE.

    DOI: 10.1016/j.actbio.2024.07.037

    PubMed

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  • Filamin A mediates embryonical palatal fusion by linking mechanotransduction with β-Catenin/Smad2 Reviewed

    Ziyi Wang, Satoru Hayano, Yao Weng, Xindi Mu, Mitsuaki Ono, Jeremie Oliver Piña, Rena N. D'Souza, Takashi Yamashiro, Toshitaka Oohashi, Hiroshi Kamioka

    2024.2

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    Authorship:Last author   Publisher:Cold Spring Harbor Laboratory  

    To decipher potential mechanisms underlying cleft palate (CP), we used advanced bioinformatic integrated with literature mining and genome-wide association study (GWAS). Re-analysis of RNA-seq data (GSE45568, GSE185279) combined with literature mining highlighted the roles of Filamin A (Flna) and Epithelial-Mesenchymal Transition (EMT) in palatal development. Immunofluorescence of in vivo palatal shelves showed increased Flna in medial edge epithelial (MEE) cells and EMT cells located in an epithelial triangle. Inhibition of TGF-β or RhoA and mechanical stimuli impacted Flna expression in ex vivo cultured palatal shelves. Re-analysis of scRNA-seq data (GSE155928) highlighted a correlation between Flna and Ctnnb1 in EMT cells. Flna knockdown affected β-catenin/Smad2 expression in cultured palatal shelves and HaCaT cells. Epithelium-specific knockout of Flna delayed palatal fusion in female mice but not males. Mendelian randomization analysis suggested that parental habitual physical activity (HPA) was causally associated with lower risk of CP in their offspring. Together, these findings suggested that parental HPA could benefit their offspring's palatal development through Flna by linking mechanotransduction with the Wnt/TGF-β/Smad signaling pathways during palatal fusion.

    DOI: 10.1101/2024.02.16.580664

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  • Comprehensive clinical evaluation of indirect and direct bonding techniques in orthodontic treatment: a single-centre, open-label, quasi-randomized controlled clinical trial Reviewed

    Kana Kono, Takashi Murakami, Saori Tanizaki, Noriaki Kawanabe, Atsuro Fujisawa, Masahiro Nakamura, Mitsuhiro Hoshijima, Takashi Izawa, Hiroshi Kamioka

    2024

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    Authorship:Last author, Corresponding author  

    DOI: 10.1093/ejo/cjae036

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Books

  • 歯科矯正学

    後藤, 滋巳, 齋藤, 功, 西井, 康, 槇, 宏太郎, 森山, 啓司, 山城, 隆, 新井, 一仁(3章 I)

    医歯薬出版  2024.9  ( ISBN:9784263456859

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    Total pages:xx, 456p   Language:Japanese

    CiNii Books

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  • 歯科矯正学

    全国歯科衛生士教育協議会, 新井, 一仁(5章4−6,7章4)

    医歯薬出版  2024.1  ( ISBN:9784263426364

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    Total pages:xvi, 230p   Language:Japanese

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  • 歯科矯正用アンカースクリューを用いた矯正歯科治療アトラス

    上岡寛, 中村政裕, 原規子, 片岡伴記, 川邉紀章, 石本和也, 出射明美( Role: Joint author)

    2019.11 

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  • 歯科矯正学

    飯田, 順一郎, 葛西, 一貴, 後藤, 滋巳, 末石, 研二, 槇, 宏太郎, 山城, 隆(歯学)( Role: Joint author ,  三章 成長発育 成長発育概論)

    医歯薬出版  2019.1  ( ISBN:9784263458327

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    Total pages:xviii, 436p   Language:Japanese

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  • 骨・臓器ネットワークとオステオサイト

    石原嘉人, 上岡 寛(骨細胞の単離と生骨中骨細胞のバイオイメージングを用いた解析)

    メディカルレビュー社  2016.2 

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MISC

  • 下顎歯列弓幅径が過大な骨格性下顎前突症に対し上顎正中三分割術により上顎骨の拡大を施行した一例

    穴田 理嵯, 早野 暁, 西山 明慶, 植田 紘貴, 伊原木 聰一郎, 上岡 寛

    日本矯正歯科学会大会プログラム・抄録集   83回   259 - 259   2024.10

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    Language:Japanese   Publisher:(公社)日本矯正歯科学会  

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  • 術前後にナゾメーターで鼻咽腔閉鎖機能を評価し上顎骨延長術により反対咬合の改善を行った口蓋裂症例の一例

    植田 紘貴, 岡 直毅, 中西 泰之, 有村 友紀, 飯田 征二, 上岡 寛

    日本顎変形症学会雑誌   34 ( 2 )   137 - 137   2024.5

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    Language:Japanese   Publisher:(NPO)日本顎変形症学会  

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  • 4切歯を含む上顎歯槽骨切り術によって歯列不正を改善した2症例

    中辻 和樹, 天野 克比古, 谷本 裕子, 河野 加奈, 有村 友紀, 永田 裕樹, 加藤 壮真, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   34 ( 2 )   191 - 191   2024.5

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    Language:Japanese   Publisher:(NPO)日本顎変形症学会  

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  • 当科における口唇口蓋裂症例に対する上顎骨骨延長術の応用

    有村 友紀, 天野 克比古, 中辻 和樹, 永田 裕樹, 加藤 壮真, 植田 紘貴, 上岡 寛, 飯田 征二

    日本顎変形症学会雑誌   34 ( 2 )   136 - 136   2024.5

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    Language:Japanese   Publisher:(NPO)日本顎変形症学会  

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  • 下顎頭の運動制限を伴う顔面非対称症例でLe Fort I骨切術と下顎枝垂直骨切術を行い運動制限が改善した一例

    竹本 史子, 植田 紘貴, 西山 明慶, 伊原木 聰一郎, 上岡 寛

    日本顎変形症学会雑誌   34 ( 2 )   177 - 177   2024.5

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    Language:Japanese   Publisher:(NPO)日本顎変形症学会  

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Presentations

  • 学童期以降の集学的治療を受けなかった左側唇顎口蓋裂成人症例に対し外科的矯正治療を行った一例

    大久保 香織[田畑], 中村 政裕, 岡本 成美, 有村 友紀, 飯田 征二, 上岡 寛

    日本口蓋裂学会雑誌  2022.4  (一社)日本口蓋裂学会

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    Event date: 2022.4

    Language:Japanese  

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  • 著しい偏位を伴った切歯骨に対し骨切り術と術後の緩徐な前方への延長により整復を図った両側唇顎口蓋裂症例

    有村 友紀, 植村 亜由美, 薬師寺 翔太, 岡本 成美, 兵藤 藍子, 三上 彩可, 竹本 史子, 早野 暁, 上岡 寛, 飯田 征二

    日本口蓋裂学会雑誌  2022.4  (一社)日本口蓋裂学会

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    Event date: 2022.4

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  • 鼻部と口蓋の一体的な光学印象を活用したPNAM作製の試みについて

    辻 重智, 植田 紘貴, 中村 政裕, 上岡 寛

    日本口蓋裂学会雑誌  2022.4  (一社)日本口蓋裂学会

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    Event date: 2022.4

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  • フッ化ナトリウムによるCCNファミリー遺伝子制御を介した歯肉線維化抑制作用の検討

    水川 朋美, 西田 崇, 明石 翔, 大杉 綾花, 大森 一弘, 中山 真彰, 高柴 正悟, 上岡 寛, 滝川 正春, 久保田 聡

    岡山歯学会雑誌  2021.12  岡山歯学会

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    Event date: 2021.12

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  • フッ化ナトリウムによるCCNファミリー遺伝子制御を介した歯肉線維化抑制作用の検討

    水川朋美、西田 崇、明石 翔、大杉綾花、大森一弘、中山真彰、高柴正悟、上岡 寛、滝川正春、久保田聡

    第42回岡山歯学会  2021.11.28  岡山歯学会

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    Event date: 2021.11.28

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:岡山市   Country:Japan  

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Awards

  • 学術大会優秀発表賞 (1件)

    2021.11   日本矯正歯科学会  

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  • 優秀ポスター賞(一般)

    2021.10   第77回日本顕微鏡学会学術講演会  

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  • 日本矯正歯科学会 学術大会優秀発表賞 (1件)

    2019.11  

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  • 学術大会優秀発表賞(5件)

    2018.11   日本矯正歯科学会  

    上岡 寛

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  • 優秀ポスター賞

    2018.7   日本骨代謝学会  

    上岡 寛

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Research Projects

  • Development of biodevices for mechanical stimulation of cells in living bone and comprehensive analysis of their mechanotransduction mechanism

    Grant number:23KK0163  2023.09 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (International Collaborative Research)

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    Grant amount:\21060000 ( Direct expense: \16200000 、 Indirect expense:\4860000 )

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  • Elucidation of early bone tissue architecture by in vivo volumetric image analysis-from both sides of cells and bone matrix

    Grant number:23H03114  2023.04 - 2027.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    上岡 寛, 原 徹, 中條 真奈, 伊豆 弥生

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    Grant amount:\18720000 ( Direct expense: \14400000 、 Indirect expense:\4320000 )

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  • Elucidation of early bone tissue construction through biological volume image analysis - from both cell and bone matrix perspectives -

    Grant number:23K27804  2023.04 - 2027.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    上岡 寛, 原 徹, 中條 真奈, 伊豆 弥生, 王 紫儀

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    Grant amount:\18720000 ( Direct expense: \14400000 、 Indirect expense:\4320000 )

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  • Challenge to elucidate the mechanism of cleft palate development from gene expression analysis linked to spatial information

    Grant number:22K19624  2022.06 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    上岡 寛, 早野 暁, 大野 充昭

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    Grant amount:\6500000 ( Direct expense: \5000000 、 Indirect expense:\1500000 )

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  • Systemic understanding about epigenetic regulatory mechanism focused on bone remodeling

    Grant number:22H03297  2022.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    井澤 俊, 加治屋 幹人, 早野 暁, 上岡 寛

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    Grant amount:\17160000 ( Direct expense: \13200000 、 Indirect expense:\3960000 )

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Class subject in charge

  • Research Presentation in Oral Health and Development (2024academic year) special  - その他

  • Training for dental visiting care (2024academic year) special  - その他

  • Practical dental care (2024academic year) Third semester  - 水7

  • Practical dental care (2024academic year) Third semester  - 水7

  • Clinical training:Early orthodontic treatment (2024academic year) special  - その他

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Social Activities

  • 歯学部リカレント教育「デジタル歯科医療の展望」

    Role(s):Lecturer

    岡山大学歯学部  2022.11.4

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    Type:Lecture

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  • メカニカルストレス応答について 大学院セミナー

    Role(s):Lecturer

    東京歯科大学口腔科学研究センター  2022.9.16

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    Type:Lecture

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  • 日本骨代謝学会「骨サミット2022」「骨質New Era」の座談会出演

    Role(s):Panelist

    日本骨代謝学会  2022.3.1

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    Type:Promotional material

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  • 岡山大学病院 口唇裂・口蓋裂総合治療センターでの活動報告

    Role(s):Lecturer, Advisor

    栃木県障害者歯科医療従事者研修事業  2022.2.3

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    Type:Lecture

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  • 第15回秋季セミナー 地域医療における矯正歯科医の役割と 各大学における研究と臨床の特色について

    Role(s):Lecturer

    東北矯正歯科学会  2021.11.23

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    Type:Lecture

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Academic Activities

  • 第2回せとうち臨床遺伝研究会 主催

    Role(s):Planning, management, etc.

    2022.2.25

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  • Bone-Bio-Engineering Kick-off Symposium

    Role(s):Planning, management, etc.

    STINT-JSPS Bilateral Joint Research Project Okayama University (Japan), Linköping University (Sweden)  2020.9.30

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    Type:Competition, symposium, etc. 

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  • 第40回日本骨形態計測学会 主催

    Role(s):Planning, management, etc.

    2020.6.18 - 2020.6.20

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  • 第61回中・四国矯正歯科学会 主催

    Role(s):Planning, management, etc.

    2018.7.7

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