Language：Japanese   Publisher：(一社)日本医療薬学会  

病棟薬剤師による外国籍患者への外国語対応について、問題点を抽出するため当院薬剤部におけるアンケート調査を実施した。さらに、言語能力に影響を受けないタブレット端末を用いた症状モニタリングツールを開発し、その有用性について検討した。病棟担当薬剤師23名を対象とした。外国語での対応について、「抵抗がある」、「やや抵抗がある」と答えた薬剤師はそれぞれ57%、26%であった。実際に薬剤師が対応した業務は「持参薬の確認」、「服薬状況の確認」および「薬剤に関する情報提供」は100%であり、「症状・副作用の確認」は93.3%であった。ロールプレイによる症状モニタリングツールの有用性の評価では、薬剤師が患者役から聴取できた症状の項目数はツール使用群では平均して3.8±1.5点であり、ツール未使用群の2.3±1.5点と比較して有意に高かった。

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J03520&link_issn=&doc_id=20190910250003&doc_link_id=10.5649%2Fjjphcs.45.513&url=https%3A%2F%2Fdoi.org%2F10.5649%2Fjjphcs.45.513&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(一社)日本医療薬学会  

添付文書に「自動車運転等の禁止等」の記載のある医薬品に対象を絞った服薬指導用紙作成時間の短縮および処方継続性が考慮された薬剤師補助用紙を作成することを目的として、服薬指導用紙作成ツールを構築し、その有用性評価を試みた。調査期間中に外来指導対象となった患者はのべ236名であり、ツール使用前後でそれぞれ118名であった。また、処方せん1枚に対する服薬指導用紙作成に要する平均時間は従来法で107.7±55秒、現行法で38.4±23秒であり、現行法のほうが服薬指導用紙作成に要する時間を有意に短縮できた。有用性に関して、「継続性確認部分」では見やすさの改善度指数が、「服薬指導用紙」では文言の分かりやすさの改善度指数が高かった。また、自由記述回答に注目すると、外来指導全体に対する総合評価では、満足度の低いグループで「どの患者に対しても同じような指導になっている」といった意見が挙げられた。

researchmap

Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J03520&link_issn=&doc_id=20190816300006&doc_link_id=%2Fdb5pharm%2F2019%2F004508%2F006%2F0470-0478%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdb5pharm%2F2019%2F004508%2F006%2F0470-0478%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：English   Publishing type：Research paper (scientific journal)  

In previous studies, we detected the photoinitiators 1-hydroxycyclohexyl phenyl ketone (1-HCHPK) and 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MTMP) in an intravenous injection solution. Importantly, 1-HCHPK and MTMP have been demonstrated to be cytotoxic to normal human peripheral blood (PB) mononuclear cells (MNC). Cell death (apoptosis) pathways can be classified into two modes, caspase-dependent and -independent pathways. However, it is unclear whether methyl 2-benzoylbenzoate (MBB) induces the caspase-dependent and/or -independent pathway in normal human PBMNC. In the present in vitro study, we examined the levels of MBB in a solution from an intravenous fluid bag and the cytotoxicity of MBB towards normal human PBMNC via the caspase-8-, caspase-9-, or apoptosis-inducing factor (AIF)-mediated apoptosis pathways. We found that extracts from the injection solution had been contaminated with approximately 80 μM of the photoinitiator MBB. In addition, MBB induced apoptosis in the high concentration range in normal human PBMNC in vitro. Moreover, we found that MBB-induced apoptosis occurs via the caspase-9 pathway, but not the AIF pathway. In conclusion, we suggest that MBB has cytotoxic effects on normal human PBMNC in vitro, which are mediated via the caspase-dependent pathway.

DOI： 10.1007/s11356-016-6332-y

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

A recent in vitro study reported that the photoinitiator 2-isopropylthioxanthone (2-ITX) is an endocrine-disrupting compound (EDC). However, it is not clear whether other photoinitiators such as 1-hydroxycyclohexyl phenyl ketone (1-HCHPK) and 2-methyl-4'-(methylthio)-2-morpholinopropiophenone (MTMP) produce endocrine-disrupting effects. The purpose of this study was thus to assess the association between estrogenic activity and exposure to photoinitiators. For estimation of the proliferative effect of the photoinitiators, the E-screen assay was used. Six photoinitiators, 2,2-dimethoxy-2-phenylacetophenone (2,2-DMPAP), 2-ethylhexyl 4-(dimethylamino)benzoate (2-EHDAB), 1-HCHPK, 2-ITX, methyl-2-benzoylbenzoate (MBB), and MTMP, significantly increased number of MCF-7 cells, an estrogen-sensitive human breast cancer cell line. In addition, pretreatment with estrogen receptor (ER) antagonists such as clomiphene, tamoxifen, or fulvestrant, significantly reversed the proliferative effect of each photoinitiator. Data demonstrated that the six photoinitiators produced endocrine-disrupting effects and that these photoinitiators interacted with ER as agonists. Evidence indicates that the six photoinitiators demonstrated estrogenic activity via ER as agonists.

DOI： 10.1080/15287394.2015.1094431

PubMed

researchmap

Language：English   Publishing type：Research paper (scientific journal)  

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib, a molecular-targeted drug, is a multi-target oral anti-neoplastic drug that is used as a first-line treatment for patients with advanced Human HCC. An increase in the expression of the cyclooxygenase-2 (COX-2) protein and sequential production of prostaglandin (PG) E2 were previously shown to significantly enhance carcinogenesis. Although the synergistic and/or additive effects of various COX inhibitors have been demonstrated in HCC, those of a combination of sorafenib and COX inhibitors remain unclear. The aim of the present study was to examine the antitumor effects of a combination of sorafenib and COX inhibitors on HCC HepG2 cells. Various COX inhibitors suppressed HepG2 cell survival, and exhibited a combined effect with sorafenib. However, COX-2 selectivity had little relevance. The co-administration of COX inhibitors and sorafenib increased the frequency of apoptosis. Moreover, the combination of sorafenib and diclofenac significantly increased Bax protein expression levels. The results of the present study indicate that COX inhibitors can be administered in combination with sorafenib for HCC therapy.

PubMed

researchmap

researchmap

Language：Japanese   Publisher：(一社)日本栄養治療学会  

researchmap

Language：Japanese   Publisher：(一社)日本栄養治療学会  

researchmap

Language：Japanese   Publisher：(一社)日本栄養治療学会  

researchmap

Language：Japanese   Publisher：(公社)日本薬学会  

researchmap

Language：Japanese   Publisher：(一社)日本毒性学会  

researchmap

Event date： 2023.6

Language：Japanese  

researchmap

Event date： 2015.3

Language：Japanese  

researchmap

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

researchmap

Language：Japanese   Presentation type：Symposium, workshop panel (nominated)  

researchmap

researchmap