研究者詳細 - 横井　彩

論文 - 横井　彩

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Relationship Between Renal Dysfunction and Oral Mucositis in Patients Undergoing Concurrent Chemoradiotherapy for Pharyngeal Cancer: A Retrospective Cohort Study 査読

HIROFUMI MIZUNO, HISATAKA MIYAI, AYA YOKOI, TERUMASA KOBAYASHI, CHIAKI INABU, TAKAYUKI MARUYAMA, DAISUKE EKUNI, NOBUYOSHI MIZUKAWA, SHIN KARIYA, KAZUNORI NISHIZAKI, YOSHIHIRO KIMATA, MANABU MORITA

In Vivo 33 ( 1 ) 183 - 189 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Anticancer Research USA Inc.

Background/Aim: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. Patients and Methods: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. Results: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). Conclusion: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.

DOI： 10.21873/invivo.11457

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New oral hygiene care regimen reduces postoperative oral bacteria count and number of days with elevated fever in ICU patients with esophageal cancer. 査読

Hirofumi Mizuno, Shinsuke Mizutani, Daisuke Ekuni, Ayano Tabata-Taniguchi, Takayuki Maruyama, Aya Yokoi, Chie Omori, Kazuyoshi Shimizu, Hiroshi Morimatsu, Yasuhiro Shirakawa, Manabu Morita

Journal of oral science 60 ( 4 ) 536 - 543 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Using a controlled pre/post study design, we investigated the effects of professional mechanical cleaning of the oral cavity with benzethonium chloride, interdental brushes, and hydrogen peroxide on the number of oral bacteria and postoperative complications among esophageal cancer patients in an intensive care unit. Before surgery, 44 patients with esophageal cancer were recruited at Okayama Hospital from January through August 2015. The control group (n = 23) received routine oral hygiene care in the intensive care unit. The intervention group (n = 21) received intensive interdental cleaning with benzethonium chloride solution and tongue cleaning with hydrogen peroxide. The number of oral bacteria on the tongue surface and plaque index were significantly lower in the intervention group than in the control group on postoperative days 1 and 2 (P < 0.05). Additionally, the number of days with elevated fever during a 1-week period was significantly lower in the intervention group than in the control group (P = 0.037). As compared with routine oral hygiene, a new oral hygiene regimen comprising benzethonium chloride, interdental brushes, and hydrogen peroxide significantly reduced the number of oral bacteria and days with elevated fever in patients with esophageal cancer.

DOI： 10.2334/josnusd.17-0381

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Does Instruction of Oral Health Behavior for Workers Improve Work Performance?-Quasi-Randomized Trial. 査読国際誌

Naoki Toyama, Ayano Taniguchi-Tabata, Nanami Sawada, Yoshio Sugiura, Daiki Fukuhara, Yoko Uchida, Hisataka Miyai, Aya Yokoi, Shinsuke Mizutani, Daisuke Ekuni, Manabu Morita

International journal of environmental research and public health 15 ( 12 ) 2018年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Oral disease can cause economic loss due to impaired work performance. Therefore, improvement of oral health status and prevention of oral disease is essential among workers. The purpose of this study was to investigate whether oral health-related behavioral modification intervention influences work performance or improves oral health behavior and oral health status among Japanese workers. We quasi-randomly separated participants into the intervention group or the control group at baseline. The intervention group received intensive oral health instruction at baseline and a self-assessment every three months. Both groups received oral examinations and answered the self-questionnaire at baseline and at one-year follow-up. At follow-up, the prevalence of subjects who use fluoride toothpastes and interdental brushes/dental floss were significantly higher in the intervention group than in the control group. Three variables (tooth brushing in workplace, using fluoride toothpaste, and experience of receiving tooth brushing instruction in a dental clinic) showed significant improvement only in the intervention group. On the other hand, work performance and oral status did not significantly change in either group. Our intensive oral health-related behavioral modification intervention improved oral health behavior, but neither work performance nor oral status, among Japanese workers.

DOI： 10.3390/ijerph15122630

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化学放射線療法中の口腔粘膜炎管理を行った症例査読

益成美保, 水野裕文, 丸山貴之, 横井彩, 小林暉政, 佐々木禎子, 志茂加代子, 三浦留美, 水川展吉, 江國大輔, 森田学

口腔衛生学会雑誌 68 ( 4 ) 231 - 237 2018年10月

記述言語：日本語出版者・発行元：(一社)日本口腔衛生学会

頭頸部がんに対する化学放射線療法(CRT)の有害事象である口腔粘膜炎による疼痛は、患者のQOLを低下させ、がん治療の完遂を困難にする。今回、われわれは術後CRTを受けている患者に対して口腔管理を行い、口腔粘膜炎および疼痛を制御した結果、がん治療の完遂に貢献できた症例を報告する。患者は67歳、男性である。右側舌がん(T2N2bM0)に対して舌可動部半側切除術、右側頸部郭清術、遊離前外側大腿皮弁による再建術を施行した。術後の病理組織検査より切除断端陽性、頸部リンパ節の節外浸潤を認めたため、術後CRT(抗がん剤:シスプラチン、5-フルオロウラシル;2クール、強度変調放射線治療60Gy)を行うこととなった。CRT前から、口腔管理および衛生実地指導を継続して行った。CRT開始時はプラークの除去を中心とした口腔管理を行った。22Gy照射時点で口腔粘膜炎(Grade2)が発症したものの、その後軽度疼痛を認める程度で経過していた。42Gy照射時点で口腔粘膜炎の悪化(Grade3)および自発痛・接触痛を認めたため、治療完遂まで毎日、歯科衛生士がプラークの除去に加え、口腔粘膜保護を目的とした口腔管理を行った。その結果、56Gy照射時点で口腔粘膜炎は改善傾向を示し(Grade2)、疼痛も緩和され、CRT完遂に至った。術後CRT開始直後から口腔粘膜炎の状態に応じた口腔管理を行うことで、疼痛の制御が成功し、CRTの完遂に貢献できたと考えられる。(著者抄録)

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職域における早食い、口腔内状態およびメタボリックシンドローム発症との関連査読

横井彩, 江國大輔, 米田俊樹, 森田学

口腔衛生学会雑誌 68 ( 1 ) 9 - 14 2018年1月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本口腔衛生学会

メタボリックシンドローム(Metabolic Syndrome:MetS)のリスク因子として早食いが挙げられる。また近年、MetsSは歯の喪失やう蝕など口腔内状態との関連も注目されている。しかし、MetS、早食いおよび口腔内状態を総合的に検討した報告は少ない。そこで、本縦断研究は、職域における早食いおよび口腔内状態とMetS発症との関連について検討することを目的とした。対象者は、某事業所における平成24・27年度定期健診をどちらも受診した従業員のうち、平成24年度MetSに該当しなかった男性114名(36〜63歳)を分析対象者とした。診査項目は、身長、体重、腹囲、血圧、空腹時血糖値、中性脂肪、HDLコレステロール値、口腔内状態、生活習慣(早食いの有無、食・運動・飲酒・喫煙習慣)とした。平成27年度健診結果から、MetS発症群と非発症群に分け、早食いの習慣および口腔内状態との関連を分析した。統計分析にはχ2検定、Fisherの直接法およびMann-Whitney U検定を用いた。3年後にMetSを発症した者(16名)は、全員早食いの自覚があった。また、MetS発症において、早食いと腹囲異常による相加効果がみられた。結論として、早食いで腹囲異常のある者はMetS発症のリスクが高いことがわかった。一方で、口腔内状態との直接的な関連はみられなかった。(著者抄録)

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Validity of a New Kit Measuring Salivary Lactate Dehydrogenase Level for Screening Gingivitis. 査読国際誌

Daisuke Ekuni, Mayu Yamane-Takeuchi, Kota Kataoka, Aya Yokoi, Ayano Taniguchi-Tabata, Hirofumi Mizuno, Hisataka Miyai, Yoko Uchida, Daiki Fukuhara, Yoshio Sugiura, Takaaki Tomofuji, Manabu Morita

Disease markers 2017 9547956 - 9547956 2017年

記述言語：英語掲載種別：研究論文（学術雑誌）

Aim. The aim of this study was to determine the usefulness of a new kit that can evaluate salivary lactate dehydrogenase (LD) level in real time for screening gingivitis. Materials and Methods. The study included 70 systemic healthy volunteers [29 males and 41 females; mean age ± SD: 24.1 ± 2.6 years]. Resting saliva was collected from each participant and LD level was evaluated in real time using the kit (a color-changing sheet with an integer scale ranging from 1 to 10). A dentist measured probing pocket depth, clinical attachment level, and the proportion of sites with bleeding on probing (% BOP) at six sites on all teeth. Gingivitis was diagnosed when the BOP value was ≥20%. Results. Salivary LD level was positively correlated with mean % BOP (odds ratio: 1.47, 95% confidence interval: 1.132-1.916, and P < 0.001) in a logistic regression model. The sensitivity and specificity of the kit were 0.89 and 0.98, respectively, at a cut-off value of 8.0 for LD level. Conclusions. The new kit for measurement of salivary LD level may be a useful tool to screen for gingivitis in young adults, which contributes to early detection of future periodontitis.

DOI： 10.1155/2017/9547956

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Relationship between acetaldehyde concentration in mouth air and tongue coating volume 査読

Aya YOKOI, Takayuki MARUYAMA, Reiko YAMANAKA, Daisuke EKUNI, Takaaki TOMOFUJI, Haruhiko KASHIWAZAKI, Yutaka YAMAZAKI, Manabu MORITA

Journal of Applied Oral Science 23 ( 1 ) 64 - 70 2015年2月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：FapUNIFESP (SciELO)

Objective: Acetaldehyde is the first metabolite of ethanol and is produced in the epithelium by mucosal ALDH, while higher levels are derived from microbial oxidation of ethanol by oral microflora such as Candida species. However, it is uncertain whether acetaldehyde concentration in human breath is related to oral condition or local production of acetaldehyde by oral microflora. The aim of this pilot study was to investigate the relationship between physiological acetaldehyde concentration and oral condition in healthy volunteers. Material and Methods: Sixty-five volunteers (51 males and 14 females, aged from 20 to 87 years old) participated in the present study. Acetaldehyde concentration in mouth air was measured using a portable monitor. Oral examination, detection of oral Candida species and assessment of alcohol sensitivity were performed. Results: Acetaldehyde concentration [median (25%, 75%)] in mouth air was 170.7 (73.5, 306.3) ppb. Acetaldehyde concentration in participants with a tongue coating status score of 3 was significantly higher than in those with a score of 1 (p<0.017). After removing tongue coating, acetaldehyde concentration decreased significantly (p<0.05). Acetaldehyde concentration was not correlated with other clinical parameters, presence of Candida species, smoking status or alcohol sensitivity. Conclusion: Physiological acetaldehyde concentration in mouth air was associated with tongue coating volume.

DOI： 10.1590/1678-775720140223

Web of Science

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Relationship between serum albumin concentration and periodontal condition in patients with head and neck cancer. 査読国際誌

Takayuki Maruyama, Reiko Yamanaka, Aya Yokoi, Daisuke Ekuni, Takaaki Tomofuji, Nobuyoshi Mizukawa, Tomoo Onoda, Motoharu Eguchi, Manabu Morita

Journal of periodontology 83 ( 9 ) 1110 - 5 2012年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Serum albumin concentration is known to be an independent predictor of survival in head and neck cancer. The previous studies suggested relationships between serum albumin concentration and oral health status in populations without serious systemic disorders. However, these relationships remain unclear in patients with head and neck cancer. The purpose of this study is to investigate the relationship between serum albumin concentration and oral health status in patients with head and neck cancer. METHODS: Fifty individuals diagnosed with primary head and neck cancer, 25 individuals with normal serum albumin concentration (≥3.85 g/dL), and 25 age- and sex-matched individuals with lower serum albumin concentration (<3.85 g/dL) were analyzed. General status, including cancer stage, body mass index, drinking and smoking habits, and biochemical serum markers, were evaluated. Oral health status, including periodontal condition and occlusion tooth pairs, were also evaluated. RESULTS: Mean clinical attachment level (CAL) and C-reactive protein in the lower serum albumin concentration group were greater than those in the normal serum albumin concentration group (P = 0.009 and P = 0.002, respectively). However, there were no significant differences in any other oral and/or serum parameters between the two serum albumin groups. A logistic regression model showed that mean CAL was significantly associated with high or low levels of serum albumin concentration (odds ratio = 9.752; 95% confidence interval = 1.702 to 55.861; P = 0.011). CONCLUSIONS: This study suggests an association between periodontal disease and serum albumin concentration in patients with head and neck cancer. Longitudinal studies are necessary to examine the causal relationship between serum albumin concentration and periodontal condition.

DOI： 10.1902/jop.2011.110536

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小学生における視力と口唇閉鎖力の関係(Relationship between Visual Acuity and Labial Closure Force in Japanese Elementary School Children) 査読

山中玲子, アクター・ラヘナ, 古田美智子, 江國大輔, 江崎光恵, 山本龍生, 岡崎好秀, 丸山貴之, 横井彩, 森田学

口腔衛生学会雑誌 61 ( 3 ) 288 - 294 2011年7月

記述言語：英語出版者・発行元：(一社)日本口腔衛生学会

口唇閉鎖力は、主に口輪筋の機能を反映している。口輪筋は発音や咀嚼などさまざまな口腔機能に関連している。口唇閉鎖力は咀嚼能力や不正咬合に関連がある。一方、裸眼視力1.0未満(<20/20)の小学生は、日本においてこの20年間増え続けている。小学生の視力低下を予防することは、重要な課題である。視力は眼輪筋の強さに関連する可能性がある。眼輪筋は口輪筋とともに顔面筋の一つであり、両者ともに顔面神経の支配を受けており、頬筋などを介して機械的にもつながっており、協調して運動する。口輪筋の強さは、眼輪筋の強さを反映していると推測される。本研究では、口唇閉鎖力が視力に関連しているという仮説を立て、小学生の視力と口唇閉鎖力の関連性を横断的に検討することを目的とした。対象は岡山市内の7歳から12歳までの小学生396名(男子197名、女子199名)とした。口腔内状態と視力は、定期健康診断の結果を用いた。口唇閉鎖力は、LIP DE CUM/LDC-110(コスモ計器、東京)を用いて測定した。典型的な不正咬合を有する16名を除外し、高視力群(≧20/20)264名と低視力群(<20/20)116名に分けた。統計分析には、Mann-Whitney U検定、χ2検定、ロジスティック回帰分析を用いた。高視力群では、口唇閉鎖力(p=0.024)と男子の割合(p=0.045)が有意に高く、年齢(p=0.001)とヘルマンの歯齢(p=0.002)が有意に低かった。性別、年齢、ヘルマンの歯齢で調整しても、低視力群では口唇閉鎖力が有意に低かった(OR 1.65、95% CI 1.04-2.64、p=0.004)。小学生において、視力と口唇閉鎖力には関連があることが示唆された。(著者抄録)

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造血器腫瘍を中心とした血液疾患患者における歯周病の重症度とPorphyromonas gingivalisに対する血清IgG抗体価との関連性に関する研究査読

曽我賢彦, 岩本義博, 谷本一郎, 浅田薫, 横井彩, 目黒道生, 工藤値英子, 吉澤さゆり, 山部こころ, 外山裕, 園井教裕, 岩田宏隆, 岡田祐佳, 冨山高史, 新井英雄, 西村英紀, 高柴正悟

日本歯科保存学雑誌 49 ( 6 ) 731 - 738 2006年12月

記述言語：日本語出版者・発行元：(NPO)日本歯科保存学会

血液疾患患者122名を対象に、歯周病原性細菌として代表的なP.gingivalisに対する血清IgG抗体価と歯周病の程度との間に関連がみられるか検討した。結果、多様な血液像(白血球減少など)を呈する血液疾患患者においても健常者と同様に歯周病の程度が重いほどIgG抗体価は高値であった。

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