記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer Science and Business Media LLC  

Abstract

Tongue pressure (TP) decreases significantly after esophagectomy in esophageal cancer patients (ECPs). Meanwhile, 2 weeks of gum-chewing training (GCT) significantly increased TP in healthy university students. We examined whether perioperative GCT would decrease the proportion of patients exhibiting a decline in TP at 2 weeks postoperatively, and prevent postoperative complications, in thoracic ECPs (TECPs). This was a single-center interventional study, and nonrandomized study with a historical control group (HCG). TECPs who underwent first-stage radical esophagectomy were recruited. Thirty-two patients of 40 in the gum-chewing group (GCG) were completed perioperative GCT in 3 times daily. Propensity score matching was performed with covariates related to TP including preoperative age, sex, body mass index, and the repetitive saliva swallowing test result, and yielded a matched cohort of 25 case pairs. Eleven GCG patients [44.0%] exhibited significantly lower TP at 2 weeks postoperatively than before esophagectomy was significantly fewer than that of 19 patients [76.0%] in the HCG. The median number of fever days (> 38 °C) in the 2 weeks after esophagectomy in the GCG was significantly fewer than those in the HCG. Perioperative GCT may prevent postoperative TP decline and postoperative dysphagia-related complications after esophagectomy.

DOI： 10.1038/s41598-024-74090-4

PubMed

researchmap

その他リンク： https://www.nature.com/articles/s41598-024-74090-4

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Antimicrobial photodynamic therapy (PDT) is a treatment that is gaining popularity in modern clinical medicine. However, little is known about the effect of PDT alone on reducing oral halitosis and the duration of the effect. This trial examined the effect of PDT on the tongue dorsum on reducing oral halitosis and the duration of the effect. This study was approved by the Ethics Committee of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, and Okayama University Hospital (CRB20-015), and it was registered in the Japan Registry of Clinical Trials (jRCTs061200060). Twenty-two participants were randomly assigned to two groups: an intervention group and control group. PDT was performed in the intervention group using red laser emission and methylene blue gel on the middle and posterior area of the tongue dorsum. The concentration of volatile sulfur compounds, bacterial count on the tongue dorsum, probing pocket depth, bleeding on probing, and simplified oral debris index score were determined before and 1 week after PDT. The Mann-Whitney U test was used to assess the significance of the differences in each parameter between the two groups. We found that the hydrogen sulfide concentration and bacterial count on the tongue dorsum were decreased in the intervention group, but there was no statistically significant difference between the two groups. These results indicated that performing only PDT on the tongue dorsum may not contribute to reducing halitosis.

DOI： 10.3390/healthcare12100980

PubMed

researchmap

記述言語：日本語   出版者・発行元：(公財)8020推進財団  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES: To survey oral status in detail and clarify the factors associated with nutritional status as evaluated by the Mini Nutritional Assessment. BACKGROUND: Malnutrition is common in older adults and increases the risk of frailty, sarcopenia, and mortality. However, few longitudinal studies have been performed to investigate the causal effect of oral status on malnutrition in detail, and the information reported in those longitudinal studies has been limited to dentition status and swallowing ability. MATERIALS AND METHODS: The participants in this prospective cohort study were patients who visited the Preventive Dentistry Clinic at Okayama University Hospital from November 2017 to January 2021. The number of teeth, periodontal condition, oral function (oral diadochokinesis, masticatory ability, number of bacteria in tongue coating, occlusal force, oral moisture, tongue pressure, swallowing function), nutritional status, the number of comorbidities, and mental health status were examined. These variables were analysed using structural equation modelling (SEM). RESULTS: The final analysis included 141 participants (40 males and 101 females; mean age, 73.5 ± 6.3 years; follow-up rate: 79.7%). The results of the SEM revealed that oral status (number of teeth present and swallowing function) was positively associated with nutritional status 2 years later. In addition, age was negatively associated with oral status. CONCLUSION: In community-dwelling older adult dental patients (age ≥60 years), oral function at baseline was associated with nutritional status two years later.

DOI： 10.1111/ger.12718

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: The purpose of the present research was to identify nutrients related to sleep bruxism and to establish a hypothesis regarding the relationship between sleep bruxism and nutrients. METHODS: We recruited 143 Japanese university students in 2021 and assigned them to sleep bruxism (n = 58) and non-sleep bruxism groups (n = 85), using an identical single-channel wearable electromyography device. To investigate nutrient intakes, participants answered a food frequency questionnaire based on food groups. We assessed differences in nutrient intakes between the sleep bruxism and non-sleep bruxism groups. RESULTS: Logistic regression modeling showed that sleep bruxism tended to be associated with dietary fiber (odds ratio, 0.91; 95% confidence interval, 0.83-1.00; p = 0.059). In addition, a subgroup analysis selecting students in the top and bottom quartiles of dietary fiber intake showed that students with sleep bruxism had a significantly lower dietary fiber intake (10.4 ± 4.6 g) than those without sleep bruxism (13.4 ± 6.1 g; p = 0.022). CONCLUSION: The present research showed that dietary fiber intake may be related to sleep bruxism. Therefore, we hypothesized that dietary fiber would improve sleep bruxism in young adults.

DOI： 10.3390/jcm12072623

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Positive psychological well-being has a favorable impact on survival rates in both healthy and unhealthy populations. Oral health is also associated with psychological well-being, is multidimensional in nature, and includes physical, psychological, emotional, and social domains that are integral to overall health and well-being. This study aimed to identify the associations between individual and environmental characteristics, oral condition and nutritional status in relation to subjective well-being among older adults using the Wilson and Cleary conceptual model. The participants were older adults (age ≥ 60 years) attending a university hospital. Subjective well-being was assessed using the World Health Organization-5 Well-Being Index, oral condition was assessed based on the number of bacteria in the tongue coating, oral wettability, tongue pressure, occlusal force, oral diadochokinesis, and masticatory ability, and subjective swallowing function was assessed using the Eating Assessment Tool, number of remaining teeth, and number of functional teeth. In addition, factors related to well-being, including social networks, life-space mobility, nutritional status, smoking history, drinking history, and medical history were assessed. In the analysis, structural equation modeling was used to investigate the association between oral condition and subjective well-being. Confirmatory factor analysis revealed oral condition as a latent variable, including tongue pressure, oral diadochokinesis /pa/, /ta/, /ka/, occlusal force, masticatory ability, subjective swallowing function, and number of functional teeth. Structural Equation Modeling revealed that oral condition was positively correlated with nutritional status, and nutritional status was positively correlated with the World Health Organization-5 Well-Being Index. These findings suggest that oral condition may influence subjective well-being via nutritional status or social environmental factors.

DOI： 10.1371/journal.pone.0295078

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVES: To clarify the associations among oral status, nutritional status and physical status in Japanese independent older adults. BACKGROUND: It is important to focus on factors affecting physical status associated with life dysfunction, long-term care and mortality. However, there are very few reports of the associations among oral status, nutritional status and physical status. MATERIALS AND METHODS: Patients who visited the Preventive Dentistry Clinic at Okayama University Hospital from November 2017 to January 2019 participated in this cross-sectional study. Number of teeth, periodontal condition and oral function were recorded. Bacteria counts in tongue dorsum, oral wettability, tongue pressure, tongue and lip movement function [oral diadochokinesis (ODK)], masticatory ability, bite force and swallowing function were measured. Nutritional status was assessed by the Mini Nutritional Assessment. Physical frailty status and Elderly Status Assessment Set were also evaluated. These variables were analysed by structural equation modelling (SEM). RESULTS: Data from 203 patients were analysed (63 males and 140 females). Patients ranged in age from 60 to 93 years. The final model of the path diagram was completed by SEM. ODK was positively associated with nutritional status, and nutritional status was negatively associated with frailty. Age was associated with ODK, nutritional status and frailty. CONCLUSION: Based on the associations among age, ODK, nutritional status and frailty, maintaining tongue movement function may contribute to good nutritional status and physical status in Japanese independent older adults.

DOI： 10.1111/ger.12593

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Oral health behaviors, risk aversion, and the health belief model are associated with health behaviors. However, there have been few studies that investigated the association between these factors and the willingness to undergo regular dental check-ups. The purpose of this cross-sectional study was to investigate the associations between the willingness of Japanese university students to undergo regular dental check-ups and oral health behaviors, the health belief model, and absolute risk aversion. An analysis was conducted with the cooperation of questionnaire respondents (n = 748) who underwent dental check-ups at Okayama University. The students answered questionnaires on oral health behaviors, the health belief model, absolute risk aversion, and willingness to undergo regular dental check-ups. The logistic regression analysis showed significant positive associations (p < 0.05) between oral health behaviors (use of the inter-dental brush and the dental floss) and the health belief model with the willingness to undergo regular dental check-ups. However, there was no significant association with absolute risk aversion (p > 0.05). These results suggest that willingness to undergo regular dental check-ups was associated with oral health behaviors and the health belief model, but not with absolute risk aversion.

DOI： 10.3390/ijerph192113920

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Self-rated oral health (SROH) is a valid, comprehensive indicator of oral health status. The purpose of this cross-sectional study was to analyze how oral health behaviors and clinical oral status were associated with SROH and how they had changed over the course of nine years in Japanese university students. Data were obtained from 17,996 students who underwent oral examinations and completed self-questionnaires from 2011 to 2019. Oral status was assessed using the decayed and filled teeth scores, bleeding on probing (BOP), probing pocket depth, the Oral Hygiene Index-Simplified (OHI-S), oral health behaviors, and related factors. SROH improved from 2011 to 2019. The logistic regression model showed that university students who were female and had a high daily frequency of tooth brushing, no BOP, no decayed teeth, no filled teeth, and a low OHI-S score and were significantly more likely to report very good, good, or fair SROH. An interaction effect was observed between survey year and regular dental check-ups (year × regular dental check-ups). The improvement trend in SROH might be associated with changes in oral health behaviors and oral health status.

DOI： 10.3390/ijerph192013580

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02171&link_issn=&doc_id=20221028310001&doc_link_id=10.11259%2Fjsg.37.2_64&url=https%3A%2F%2Fdoi.org%2F10.11259%2Fjsg.37.2_64&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）  

In modern society, evaluation and management of psychological stress may be important for the prevention of periodontal disease. The purpose of this study was to examine the relationship between psychological stress (vitality and mental activity) evaluated by Mind Monitoring System (MIMOSYS) and periodontal status. Forty students of Okayama University underwent the oral examination and self-reported questionnaire on the first day (baseline) and the 14th day (follow-up). Voice recording was performed every day with the MIMOSYS app during the whole study period. The participants completed the Patient Health Questionnaire (PHQ)-9 and Beck Depression Inventory (BDI) at baseline and at follow-up. Spearman's rank correlation coefficient was used to determine the significance of correlations among variables. The PHQ-9 and BDI scores were negatively correlated with vitality in the morning. Change in vitality in the morning was significantly correlated with changes in periodontal inflammation. Mental activity was significantly correlated with change in mean probing pocket depth. This result shows that measurement of psychological stress using a voice-based tool to assess mental health may contribute to the early detection of periodontal disease.

DOI： 10.3390/ijerph19159489

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1111/jre.12979

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/microorganisms10051000

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph19042490

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph19031145

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

INTRODUCTION: The aim of the present study was to characterize the profile and diversity of the oral microbiome of a periodontally non-severe group with ≥20 teeth in comparison with a severe periodontitis group of elderly Japanese people. METHODS: A total of 50 patients who had ≥20 teeth and aged ≥60 years were recruited, and 34 participants (13 non-severe participants) were analyzed. After oral rinse (saliva after rinsing) sample collection, the V3-V4 regions of the 16S rRNA gene were sequenced to investigate microbiome composition, alpha diversity (Shannon index, Simpson index, richness, and evenness), and beta diversity using principal coordinate analysis (PCoA) based on weighted and unweighted UniFrac distances. A linear discriminant analysis effect size was calculated to identify bacterial species in the periodontally non-severe group. RESULTS: The periodontally non-severe group showed lower alpha diversity than that of the severe periodontitis group (p <0.05); however, the beta diversities were not significantly different. A higher relative abundance of four bacterial species (Prevotella nanceiensis, Gemella sanguinis, Fusobacterium periodonticum, and Haemophilus parainfluenzae) was observed in the non-severe group than that in the severe periodontitis group. CONCLUSION: The oral microbiome in elderly Japanese people with ≥20 teeth and a non-severe periodontal condition was characterized by low alpha diversity and the presence of four bacterial species.

DOI： 10.3389/fcimb.2022.957890

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph18189548

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph18158010

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph18126430

Scopus

PubMed

researchmap

担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

DOI： 10.1111/jcpe.13432

Scopus

PubMed

researchmap

その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jcpe.13432

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1080/00016357.2020.1795249

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s40520-020-01547-7

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI AG  

DOI： 10.3390/ijerph18010324

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Although some studies showed that lifestyle was associated with oral health behavior, few studies investigated the association between household type and oral health behavior. The aim of this prospective cohort study was to investigate the association between household type, oral health behavior, and periodontal status among Japanese university students. Data were obtained from 377 students who received oral examinations and self-questionnaires in 2016 and 2019. We assessed periodontal status using the percentage of bleeding on probing (%BOP), probing pocket depth, oral hygiene status, oral health behaviors, and related factors. We used structural equation modeling to determine the association between household type, oral health behaviors, gingivitis, and periodontitis. At follow-up, 252 students did not live with their families. The mean ± standard deviation of %BOP was 35.5 ± 24.7 at baseline and 32.1 ± 25.3 at follow-up. In the final model, students living with their families were significantly more likely to receive regular dental checkup than those living alone. Regular checkup affected the decrease in calculus. The decrease in calculus affected the decrease in %BOP over 3 years. Living with family was directly associated with regular dental checkups and indirectly contributed to gingival status among Japanese university students.

DOI： 10.3390/ijerph18010324

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：MDPI AG  

DOI： 10.3390/ijerph17228623

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The long-term effects of secondhand smoke (SHS) on dental caries among Japanese young adults remain unclear. The purpose of this cross-sectional study was to evaluate whether household exposure to SHS is associated with dental caries in permanent dentition among Japanese young adults. The study sample included 1905 first-year university students (age range: 18-19 years) who answered a questionnaire and participated in oral examinations. The degree of household exposure to SHS was categorized into four levels according to the SHS duration: no experience (-), past, current SHS < 10 years, and current SHS ≥ 10 years. Dental caries are expressed as the total number of decayed, missing, and filled teeth (DMFT) score. The relationships between SHS and dental caries were determined by logistic regression analysis. DMFT scores (median (25th percentile, 75th percentile)) were significantly higher in the current SHS ≥ 10 years (median: 1.0 (0.0, 3.0)) than in the SHS-(median: 0.0 (0.0, 2.0)); p = 0.001). DMFT ≥ 1 was significantly associated with SHS ≥ 10 years (adjusted odds ratio: 1.50, 95% confidence interval: 1.20-1.87, p < 0.001). Long-term exposure to SHS (≥10 years) was associated with dental caries in permanent dentition among Japanese young adults.

DOI： 10.3390/ijerph17228623

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00440&link_issn=&doc_id=20201110210001&doc_link_id=%2Fdk1dehea%2F2020%2F007004%2F001%2F0190-0195%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2020%2F007004%2F001%2F0190-0195%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00440&link_issn=&doc_id=20201110210004&doc_link_id=%2Fdk1dehea%2F2020%2F007004%2F004%2F0215-0221%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2020%2F007004%2F004%2F0215-0221%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Spandidos Publications  

Salivary peroxidase and myeloperoxidase are known to display antibacterial activity against oral microbes, and previous indications have pointed to the possibility that horseradish peroxidase (HRP) adsorbs onto the membrane of the major oral streptococci, Streptococcus mutans and Streptococcus sanguinis (S. sanguinis). However, the mechanism of interaction between HRP and the bacterial cell wall component is unclear. Dental plaques containing salivary glycoproteins and extracellular microbial products are visualized with 'dental plaque disclosing agent', and are controlled within dental therapy. However, current 'dental plaque disclosing agents' are difficult to evaluate with just dental plaques, since they stain and disclose not only dental plaques but also pellicle formed with salivary glycoproteins on a tooth surface. In this present study, we have demonstrated that HRP interacted with the cell wall component of the major gram-positive bacterial peptidoglycan, but not the major cell wall component of gram-negative bacteria lipopolysaccharide. Furthermore, we observed that the adsorbed HRP labeled with fluorescence was detected on the major oral gram-positive strains S. sanguinis and Streptococcus salivarius (S. salivarius), but not on a gram-negative strain, Escherichia coli (E. coli). Furthermore, we have demonstrated that the combination of HRP and chromogenic substrate clearly disclosed the dental plaques and the biofilm developed by S. sanguinis, S. salivarius and the major gram-postive bacteria Lactobacillus casei on tooth surfaces, and slightly disclosed the biofilm by E. coli. The combination of HRP and chromogenic substrate did not stain either the dental pellicle with the salivary glycoprotein mucin, or naked tooth surfaces. These results have suggested the possibility that the adsorption activity of HRP not only contributes to the evaluation of dental plaque, but that enzymatic activity of HRP may also contribute to improve dental hygiene.

DOI： 10.3892/etm.2020.9016

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Salivary peroxidase and myeloperoxidase are known to display antibacterial activity against oral microbes, and previous indications have pointed to the possibility that horseradish peroxidase (HRP) adsorbs onto the membrane of the major oral streptococci, Streptococcus mutans and Streptococcus sanguinis (S. sanguinis). However, the mechanism of interaction between HRP and the bacterial cell wall component is unclear. Dental plaques containing salivary glycoproteins and extracellular microbial products are visualized with 'dental plaque disclosing agent', and are controlled within dental therapy. However, current 'dental plaque disclosing agents' are difficult to evaluate with just dental plaques, since they stain and disclose not only dental plaques but also pellicle formed with salivary glycoproteins on a tooth surface. In this present study, we have demonstrated that HRP interacted with the cell wall component of the major gram-positive bacterial peptidoglycan, but not the major cell wall component of gram-negative bacteria lipopolysaccharide. Furthermore, we observed that the adsorbed HRP labeled with fluorescence was detected on the major oral gram-positive strains S. sanguinis and Streptococcus salivarius (S. salivarius), but not on a gram-negative strain, Escherichia coli (E. coli). Furthermore, we have demonstrated that the combination of HRP and chromogenic substrate clearly disclosed the dental plaques and the biofilm developed by S. sanguinis, S. salivarius and the major gram-postive bacteria Lactobacillus casei on tooth surfaces, and slightly disclosed the biofilm by E. coli. The combination of HRP and chromogenic substrate did not stain either the dental pellicle with the salivary glycoprotein mucin, or naked tooth surfaces. These results have suggested the possibility that the adsorption activity of HRP not only contributes to the evaluation of dental plaque, but that enzymatic activity of HRP may also contribute to improve dental hygiene.

DOI： 10.3892/etm.2020.9016

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00440&link_issn=&doc_id=20200818320003&doc_link_id=%2Fdk1dehea%2F2020%2F007003%2F003%2F0144-0151%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2020%2F007003%2F003%2F0144-0151%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph17103713

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(公社)日本産業衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The purpose of this cross-sectional study was to investigate the association between sleep quality and duration, and periodontal disease among a group of young Japanese university students. First-year students (n = 1934) at Okayama University who voluntarily underwent oral health examinations were included in the analysis. Sleep quality and duration were assessed by the Japanese version of the Pittsburgh Sleep Quality Index. Dentists examined Oral Hygiene Index-Simplified (OHI-S), probing pocket depth (PPD), and percentage of sites with bleeding on probing (BOP). Periodontal disease was defined as presence of PPD ≥ 4 mm and BOP ≥ 30%. Overall, 283 (14.6%) students had periodontal disease. Poor sleep quality was observed among 372 (19.2%) students. Mean (± standard deviation) sleep duration was 7.1 ± 1.1 (hours/night). In the logistic regression analysis, periodontal disease was significantly associated with OHI-S (odds ratio [OR]: 2.30, 95% confident interval [CI]: 1.83-2.90; p < 0.001), but not sleep quality (OR: 1.09, 95% CI: 0.79-1.53; p = 0.577) or sleep duration (OR: 0.98, CI: 0.87-1.10; p = 0.717). In conclusion, sleep quality and duration were not associated with periodontal disease among this group of young Japanese university students.

DOI： 10.3390/ijerph17093034

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.sleep.2019.09.003

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph17051764

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

PURPOSE: The purpose of this intervention study was to investigate whether intensive health guidance focusing on eating quickly can prevent metabolic syndrome (MetS) more effectively than standard routine guidance in Japanese citizens living in rural areas. METHODS: This controlled, non-randomized, intervention study analyzed 141 participants with MetS at baseline. Participants in the intervention group received health guidance focusing on eating quickly and standard health guidance about MetS in accordance with the guidelines of the Ministry of Health, Labour and Welfare in Japan, whereas participants in the control group received only standard health guidance about MetS. The primary study outcome was the prevalence of MetS at a 1-year follow-up. RESULTS: At 1-year follow-up, the prevalence of MetS in the intervention group was significantly lower than that in the control group (p = 0.003). The decreases in body weight, body mass index, waist circumference and triglycerides from baseline to 1 year were significantly greater in the intervention group than in the control group (p < 0.05). CONCLUSION: Intensive health guidance focusing on eating quickly is more effective for improving MetS than standard Japanese health guidance alone. LEVEL OF EVIDENCE: Level II, Evidence obtained from well-designed controlled trials without randomization. TRIAL REGISTRY NAME, REGISTRATION IDENTIFICATION NUMBER, AND URL FOR THE REGISTRY: UMIN, UMIN000030600, http://www.umin.ac.jp/ctr/index-j.htm.

DOI： 10.1007/s40519-018-0522-1

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1038/s41598-020-58396-7

Scopus

PubMed

researchmap

掲載種別：研究論文（学術雑誌）   出版者・発行元：Anticancer Research USA Inc.  

DOI： 10.21873/invivo.11752

Scopus

PubMed

researchmap

掲載種別：研究論文（学術雑誌）   出版者・発行元：Anticancer Research USA Inc.  

DOI： 10.21873/invivo.11815

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1371/journal.pone.0236259

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND/AIM: miRNA molecules have been attracting attention as genetic modifiers between organs. We examined the relationship between serum miRNA and targeted liver mRNA profiles in a periodontitis rat model, and the influence of periodontitis on the liver. MATERIALS AND METHODS: Male Wistar rats (n=16, 8 weeks old) were randomly divided into two groups (8 rats each): control and periodontitis (ligature placement for 4 weeks). Serum miRNA and liver mRNA profiles were compared. RESULTS: Periodontal destruction and hepatocyte apoptosis were induced in the periodontitis group. Microarray analysis indicated that 52 serum miRNAs and 33 liver mRNAs were expressed with a >1.5-fold change (FC) and a >2.0-FC (p<0.05), respectively, between the two groups. From the miRNA target genes, 12 genes equivalented to liver mRNAs with a >2.0-FC, among which, Hyou1, Chac1, and Bloc1s3 have apoptotic functions in our model. miRNAs upstream of these 3 mRNAs are miR-3591, miR-181a-2-3p and miR-6321. CONCLUSION: miR-3591, miR-181a-2-3p and miR-6321 induced hepatocyte apoptosis in our periodontitis rat model.

DOI： 10.21873/invivo.11752

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND/AIM: The purpose of this study was to determine the anti-aging effects of coffee intake on oxidative stress in rat periodontal tissue and alveolar bone loss. MATERIALS AND METHODS: Male Fischer 344 rats (8 weeks old) were randomized to four groups; the baseline group immediately sacrificed, the control group fed with normal powdered food for 8 weeks, and the experimental groups fed with powdered food containing 0.62% or 1.36% coffee components for 8 weeks. RESULTS: Alveolar bone loss and gingival level of 8-hydroxydeoxyguanosine were significantly lower in the 1.36% coffee group than in the control group. Nuclear factor erythroid 2-related factor 2 translocation to the nucleus was significantly higher in the 1.36% coffee group than in the control group. CONCLUSION: Continuous intake of 1.36% coffee could prevent age-related oxidative stress in the periodontal tissue and alveolar bone loss, possibly by up-regulating the Nrf2 signaling pathway.

DOI： 10.21873/invivo.11815

PubMed

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s11136-019-02251-4

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph16214252

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph16193540

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph16173070

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10388-019-00668-x

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: Acetaldehyde, associated with consumption of alcoholic beverages, is known to be a carcinogen and to be related to the tongue dorsum. The aim of this study was to investigate the relationship between acetaldehyde concentration in mouth air and bacterial characteristics on the tongue dorsum. METHODOLOGY: Thirty-nine healthy volunteers participated in the study. Acetaldehyde concentrations in mouth air were evaluated by a high-sensitivity semiconductor gas sensor. A 16S rRNA gene sequencing technique was used to compare microbiomes between two groups, focusing on the six samples with the highest acetaldehyde concentrations (HG) and the six samples with lowest acetaldehyde concentrations (LG). RESULTS: Acetaldehyde concentration increased in correlation with the increase in bacterial count (p=0.048). The number of species observed in the oral microbiome of the HG was higher than that in the oral microbiome of the LG (p=0.011). The relative abundances of Gemella sanguinis, Veillonella parvula and Neisseria flavescens in the oral microbiome of the HG were higher than those in the oral microbiome of the LG (p<0.05). CONCLUSION: Acetaldehyde concentration in mouth air was associated with bacterial count, diversity of microbiome, and relative abundance of G. sanguinis, V. parvula, and N. flavescens.

DOI： 10.1590/1678-7757-2018-0635

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1590/1678-7757-2018-0635

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.archoralbio.2019.03.009

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00440&link_issn=&doc_id=20190521100005&doc_link_id=%2Fdk1dehea%2F2019%2F006902%2F005%2F0098-0105%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2019%2F006902%2F005%2F0098-0105%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2334/josnusd.18-0038

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The purpose of this cross-sectional pilot study was to find salivary microRNAs (miRNAs) reflecting periodontal condition in chronic periodontitis. One hundred and twenty chronic periodontitis patients (mean age, 68.4 years) participated in the study, from whom unstimulated whole saliva was collected. A multiphase study was conducted to explore salivary miRNAs as biomarkers of periodontitis. At first, a polymerase chain reaction (PCR) array was performed to compare salivary miRNAs profiles in no and mild (no/mild) and severe periodontitis patients. Next, the relative expression of salivary miRNAs on individual samples was assessed by real-time reverse transcription-PCR. The numbers (%) of patients were 26 (21.6%, no/mild), 58 (48.3%, moderate) and 36 (30.0%, severe), respectively. Among 84 miRNAs, only the relative expression of hsa-miR-381-3p in the severe periodontitis group was significantly higher than that of the no/mild periodontitis group (p < 0.05). Among the 120 patients, there was also a significant correlation between the relative expression of hsa-miR-381-3p and the mean probing pocket depth (PPD) (r = 0.181, p < 0.05). Salivary hsa-miR-381-3p was correlated with periodontitis condition in chronic periodontitis patients.

DOI： 10.3390/molecules24061034

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/molecules24061034

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph16050690

Scopus

PubMed

researchmap

掲載種別：研究論文（学術雑誌）  

DOI： 10.21873/invivo.11457

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.18332/tid/111538

Web of Science

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND/AIM: The aim of this retrospective cohort study was to investigate the association between renal dysfunction (RD) and the development of oral mucositis (OM) in patients undergoing concurrent chemoradiotherapy (CCRT) for pharyngeal cancer including radiation to the oral cavity. PATIENTS AND METHODS: Of 130 patients diagnosed as having pharyngeal cancer who received CCRT at the Okayama University Hospital Head and Neck Cancer Center, 44 were finally selected. RESULTS: During the observation period, 24 (54.5%) patients experienced severe OM (grade 3). The Cox proportional hazards regression model demonstrated that RD (hazard ratio(HR)=2.45, 95% confidence interval(CI)=1.067-6.116, p=0.035) and nasopharynx/oropharynx as center of the irradiated area (HR=2.56, 95% CI=1.072-5.604, p=0.034) were significantly associated with the incidence of severe OM (grade 3). CONCLUSION: In patients with pharyngeal cancer treated with CCRT including radiation to the oral cavity, RD at baseline can be a risk factor for developing severe OM.

DOI： 10.21873/invivo.11457

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Using a controlled pre/post study design, we investigated the effects of professional mechanical cleaning of the oral cavity with benzethonium chloride, interdental brushes, and hydrogen peroxide on the number of oral bacteria and postoperative complications among esophageal cancer patients in an intensive care unit. Before surgery, 44 patients with esophageal cancer were recruited at Okayama Hospital from January through August 2015. The control group (n = 23) received routine oral hygiene care in the intensive care unit. The intervention group (n = 21) received intensive interdental cleaning with benzethonium chloride solution and tongue cleaning with hydrogen peroxide. The number of oral bacteria on the tongue surface and plaque index were significantly lower in the intervention group than in the control group on postoperative days 1 and 2 (P < 0.05). Additionally, the number of days with elevated fever during a 1-week period was significantly lower in the intervention group than in the control group (P = 0.037). As compared with routine oral hygiene, a new oral hygiene regimen comprising benzethonium chloride, interdental brushes, and hydrogen peroxide significantly reduced the number of oral bacteria and days with elevated fever in patients with esophageal cancer.

DOI： 10.2334/josnusd.17-0381

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/ijerph15122630

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1002/JPER.17-0567

Web of Science

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

BACKGROUND: Commensal flora are involved in the appropriate development of the mature immune system. However, it is unclear how commensal flora contribute to immune responses against periodontal pathogens, including the response to lipopolysaccharide (LPS). The purpose of this study was to evaluate the expression of immune responses after topical application of LPS in germ-free (GF) and specific-pathogen-free (SPF) mice. METHODS: GF and SPF mice at 8 weeks of age were randomly divided into four groups each: a baseline group (n = 4/group) and three experimental groups (n = 6/group). Experimental groups received topical application of Porphyromonas gingivalis LPS (10 μg/μL) into the palatal gingival sulcus. Sampling was performed before LPS application (baseline) and at 3, 24, or 72 hours after LPS application. The numbers of neutrophils, CD4+ , and CD8+ T cells in periodontal tissue were evaluated by immunohistochemistry. Expression of genes encoding cytokines, chemokines, and a transcription factor was determined by real-time PCR. RESULTS: SPF mice, but not GF mice, showed an increased number of CD4+ T cells in the periodontal tissue at 3 hours after LPS application, compared with the number at baseline (p < 0.05). Gene expressions of tumor necrosis factor-α (Tnf-α) and forkhead box protein p3 (Foxp3) was also significantly higher in the SPF mice than in the GF mice at 3 hours after LPS application (p < 0.05). The number of neutrophils peaked at 24 hours in both GF and SPF mice. CONCLUSIONS: LPS-exposed SPF mice exhibited increases in the number of CD4+ T cells and in Tnf-α and Foxp3 gene expression in periodontal tissue compared with LPS-exposed GF mice.

DOI： 10.1002/JPER.17-0567

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Severe oral mucositis occurs frequently in patients receiving hematopoietic stem cell transplantation (HCT). Oral mucosal bacteria can be associated with progression of oral mucositis, and systemic infection may occur via ulcerative oral mucositis. However, little information is available regarding the oral microbiota after HCT. Here, PCR-denaturing gradient gel electrophoresis (DGGE) was performed to characterize the oral mucosal microbiota, which can be affected by antibiotics, before and after HCT. Sixty reduced-intensity HCT patients were enrolled. Three patients with the least antibiotic use (quinolone prophylaxis and/or β-lactam monotherapy group) and three patients with the most antibiotic use (β-lactam-glycopeptide combination therapy group) were selected. Bacterial DNA samples obtained from the oral mucosa before and after HCT were subjected to PCR-DGGE. The trajectory of oral mucositis was evaluated. The oral mucosal microbiota in the β-lactam-glycopeptide combination therapy group was different from that in the quinolone prophylaxis and/or β-lactam monotherapy group, and Staphylococcus spp. and Enterococcus spp. were identified. Lautropia mirabilis was dominant in one patient. Ulcerative oral mucositis was observed only in the β-lactam-glycopeptide combination therapy group. In conclusion, especially with the use of strong antibiotics, such as glycopeptides, the oral mucosal microbiota differed completely from that under normal conditions and consisted of Staphylococcus spp., Enterococcus spp., and unexpectedly L. mirabilis. The normal oral microbiota consists not only of bacteria, but these unexpected bacteria could be involved in the pathophysiology as well as systemic infection via oral mucositis. Our results can be used as the basis for future studies in larger patient populations.

DOI： 10.1007/s12223-018-0596-1

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2334/josnusd.17-0381

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Recent studies suggest that the commensal microbiota affects not only host energy metabolism and development of immunity but also bone remodeling by positive regulation of osteoclast activity. However, the mechanism of regulation of bone cells by the commensal microbiota has not been elucidated. In this study, 8-week-old specific pathogen-free (SPF) and germ-free (GF) mice were compared in terms of alveolar bones and primary osteoblasts isolated from calvarias. Micro-CT analysis showed that SPF mice had larger body size associated with lower bone mineral density and bone volume fraction in alveolar bones compared with GF mice. Greater numbers of osteoclasts in alveolar bone and higher serum levels of tartrate-resistant acid phosphatase 5b were observed in SPF mice. Tissue extracts from SPF alveolar bone showed higher levels of cathepsin K, indicating higher osteoclast activity. SPF alveolar extracts also showed elevated levels of γ-carboxylated glutamic acid⁻osteocalcin as a marker of mature osteoblasts compared with GF mice. Polymerase chain reaction (PCR) array analysis of RNA directly isolated from alveolar bone showed that in SPF mice, expression of mRNA of osteocalcin, which also acts as an inhibitor of bone mineralization, was strongly enhanced compared with GF mice. Cultured calvarial osteoblasts from SPF mice showed reduced mineralization but significantly enhanced expression of mRNAs of osteocalcin, alkaline phosphatase, insulin-like growth factor-I/II, and decreased ratio of osteoprotegerin/receptor activator of nuclear factor-kappa B ligand compared with GF mice. Furthermore, PCR array analyses of transcription factors in cultured calvarial osteoblasts showed strongly upregulated expression of Forkhead box g1. In contrast, Gata-binding protein 3 was strongly downregulated in SPF osteoblasts. These results suggest that the commensal microbiota prevents excessive mineralization possibly by stimulating osteocalcin expression in osteoblasts, and enhances both osteoblast and osteoclast activity by regulating specific transcription factors.

DOI： 10.3390/molecules23071517

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer International Publishing  

DOI： 10.1007/s40519-018-0522-1

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.archoralbio.2018.02.021

Web of Science

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/molecules23071517

Web of Science

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: This study was conducted to investigate whether the masseter muscle activity shows any specific pattern in relation to the severity of periodontitis. DESIGN: Sixteen subjects with no or mild periodontitis (NMP group) and 15 subjects with moderate or severe periodontitis (MSP group) were enrolled. Plasma IgG antibody titer was examined using Porphyromonas gingivalis as a bacterial antigen. Surface electromyography (EMG) of the masseter muscles was continuously recorded using an ambulatory surface EMG recording device while patients were awake and asleep. Masseter muscle activity was analyzed using intensities of 5%-10% maximal voluntary clenching (MVC), 10%-20% MVC, and >20% MVC. Furthermore, EMG levels of 20% MVC were adopted as the threshold for analysis of phasic, tonic, and mixed EMG activities. The cumulative duration of masseter muscle activity and bruxism episodes was calculated as duration per hour. RESULTS: There was no significant difference in plasma IgG antibody titers against P. gingivalis between the NMP and MSP groups (p = 0.423). During waking hours, the duration of masseter muscle activity with an intensity of >20% MVC was significantly longer in the MSP group than in the NMP group (p = 0.037). During sleeping hours, the duration of masseter muscle activity at all MVC intensities was significantly longer in the MSP group than in the NMP group (all p < 0.05). Additionally, the duration of phasic and mixed episodes was significantly longer in the MSP group than those in the NMP group while both awake and asleep (all p < 0.05). CONCLUSIONS: The results of this study suggested that masseter muscle activity might be related to the severity of periodontitis.

DOI： 10.1016/j.archoralbio.2018.02.021

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier Ltd  

DOI： 10.1016/j.archoralbio.2017.12.007

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: Increasing age is a potential risk factor for periodontal tissue breakdown, which may be affected by commensal flora. The aim of this study evaluated age-related changes in CD4+ T cells, C-C chemokine ligand 5 (CCL5), interleukin (IL)-17A, and receptor activator of nuclear factor-kappa B ligand (RANKL) expression using germ-free (GF) and conventionally reared (SPF) mice. DESIGN: GF and SPF mice at 8 (n = 6/group) and 22 weeks old (n = 6/group) were used. Immunohistochemical analyses were performed to determine the effects of aging on protein expression in periodontal tissues. Age-related changes in alveolar bone were quantified using micro-CT analysis. RESULTS: SPF mice, but not GF mice, showed an age-related increase in alveolar bone loss (P < 0.01). SPF mice at 22 weeks of age increased expression of CD4+ T cells, CCL5, IL-17A, and RANKL compared to those at 8 weeks of age in connective tissue and alveolar bone surface (P < 0.01). Furthermore, there was increased CD4+ T cells, which were co-expressed with IL-17A and RANKL in SPF mice at 22 weeks of age. On the other hand, the GF mice did not show any significant differences in CD4+ T cells, CCL5, IL-17A and RANKL expression between the two age groups. CONCLUSIONS: SPF mice induced an age-related increase in CD4+ T cells co- expressed with IL-17A and RANKL, with occurring alveolar bone loss. In contrast, GF mice did not show age-related changes in CD4+ T cell migration and cytokine expression.

DOI： 10.1016/j.archoralbio.2017.12.007

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

OBJECTIVE: The purpose of this study was to investigate the preventive effects of topical application of green tea catechins on tongue oxidative stress induced by 5-fluorouracil (5-FU) administration in rats. DESIGN: Male Wistar rats (n=28, 8 weeks old) were divided into four groups of seven rats each: a negative control group (saline administration and application of ointment without green tea catechins), a positive control group (5-FU administration and application of ointment without green tea catechins), and two experimental groups (5-FU administration and application of ointment containing 0.1% or 0.5% green tea catechins). Topical application of each ointment to the ventral surface of the tongue was performed once a day for 5days. The level of 8-hydroxydeoxyguanosine (8-OHdG) was determined to evaluate oxidative stress. Fluorescence staining was also performed to confirm nuclear factor erythroid 2-related factor 2 (Nrf2) translocation to the nucleus. RESULTS: After the experimental period, the ratios of 8-OHdG-positive cells in the ventral tongue tissue were higher in the positive control group than in the negative control group (P<0.05). On the other hand, those in the 0.5% green tea catechin group, but not in the 0.1% green tea catechin group, were lower than the positive control group (P<0.05). In addition, Nrf2 translocation to the nucleus was greater in the 0.5% green tea catechin group than in the positive control group (P<0.05). CONCLUSIONS: Topical application of ointment containing 0.5% green tea catechins could prevent tongue oxidative stress in 5-FU administered rats, via up-regulation of the Nrf2 signaling pathway.

DOI： 10.1016/j.archoralbio.2017.06.025

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

AIM: The purpose of this study was to investigate the effects of non-surgical periodontal treatment on hemoglobinA1c (HbA1c) levels, oxidative stress balance and quality of life (QOL) in patients with type 2 diabetes mellitus (T2DM) compared to no periodontal treatment (simple oral hygiene instructions only). METHODS: The design was a 6-month, single-masked, single center, randomized clinical trial. Patients had both T2DM and chronic periodontitis. Forty participants were enrolled between April 2014 and March 2016 at the Nephrology, Diabetology and Endocrinology Department of Okayama University Hospital. The periodontal treatment group (n = 20) received non-surgical periodontal therapy, including scaling and root planing plus oral hygiene instructions, and consecutive supportive periodontal therapy at 3 and 6 months. The control group (n = 17) received only oral hygiene instructions without treatment during the experimental period. The primary study outcome was the change in HbA1c levels from baseline to 3 months. Secondary outcomes included changes in oxidative stress balance (Oxidative-INDEX), the Diabetes Therapy-Related QOL and clinical periodontal parameters from baseline to 3 months and baseline to 6 months. RESULTS: Changes in HbA1c in the periodontal treatment group were not significantly different with those in the control group at 3 and 6 months. Systemic oxidative stress balance and QOL significantly improved in the periodontal treatment group compared to the control group at 3 months. In the subgroup analysis (moderately poor control of diabetes), the decrease in HbA1c levels in the periodontal treatment group was greater than that in the control group at 3 months but not significant. CONCLUSIONS: In T2DM patients, non-surgical periodontal treatment improved systemic oxidative stress balance and QOL, but did not decrease HbA1c levels at 3 months follow-up. TRIAL REGISTRATION: Current Controlled Trials UMIN-ICDR UMIN 000013278 (Registered April 1, 2014).

DOI： 10.1371/journal.pone.0188171

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(公財)上原記念生命科学財団  

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

When plasma ROM level in periodontitis patients was low, increases in plasma ROM level were associated with those in CAL during the maintenance phase of treatment.

DOI： 10.1155/2014/489292

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina?) to the gingival surface on gingival collagen degradation in rats. Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina? (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months. In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p &lt; 0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p &lt; 0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months. These findings indicate that Tomarina? might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model.

DOI： 10.1016/j.archoralbio.2013.09.008

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2012&ichushi_jid=J00440&link_issn=&doc_id=20120809250005&doc_link_id=%2Fdk1dehea%2F2012%2F006204%2F005%2F0384-0390%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2012%2F006204%2F005%2F0384-0390%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

掲載種別：論文集(書籍)内論文  

Scopus

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

adding green tea catechins to a dentifrice may contribute to prevention of periodontal inflammation by decreasing gingival oxidative stress and expression of pro-inflammatory cytokines.

DOI： 10.1016/j.archoralbio.2010.08.015

PubMed

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Systemic low-grade inflammation after experimental periodontitis was associated with increased gene expression for hepatic levels of TNF-alpha and CRP and adipose tissue levels of IL-6 and CRP in the obese-rat model.

DOI： 10.1902/jop.2009.090574

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The combination of obesity and its associated risk factors, such as insulin resistance and inflammation, results in the development of atherosclerosis. However, the effects of periodontitis on atherosclerosis in an obese body remain unclear. The aim of the study was to investigate the effects of ligature-induced periodontitis in Zucker fatty rats on initiation of atherosclerosis by evaluating aortic insulin resistance. Zucker fatty rats (n=24) were divided into two groups. In the periodontitis group, periodontitis was ligature-induced for 4 weeks, whereas the control group was left unligated. After the 4-week experimental period, descending aorta was used for measuring the levels of lipid deposits, immunohistochemical analysis, and evaluation of gene expression. Levels of serum C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and insulin were also measured. Rats in the periodontitis group had significantly enhanced lipid deposits in the aorta, but not in the control group. Expression of suppressor of cytokine signaling 3, vascular cell adhesion molecule 1, reactive oxygen species, nitrotyrosine, and endothelin-1 in the periodontitis group was more intense than that in the control group. Significantly decreased levels of phosphatidylinositol 3-kinase (Pi3k) catalytic beta-polypeptide (Pi3kcb), Pi3kp85, and insulin receptor substrate 1 and 2 were observed in the periodontitis group. Levels of serum CRP and TNF-alpha were significantly increased in the periodontitis group. Under insulin-stimulated conditions, aorta in the periodontitis group altered the Akt phosphorylation. Periodontitis in obesity induced the initial stage of atherosclerosis and disturbed aortic insulin signaling.

DOI： 10.1038/labinvest.2009.141

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：1  

DOI： 10.3109/00016350903291913

Scopus

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Imbalance of circulating oxidative/anti-oxidative status may be involved in vacuolisation and apoptosis of submandibular glands in the rat periodontitis model.

DOI： 10.1016/j.archoralbio.2009.11.013

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Consuming a cocoa-enriched diet could diminish periodontitis-induced oxidative stress, which, in turn, might suppress the progression of periodontitis.

DOI： 10.1902/jop.2009.090270

PubMed

researchmap

記述言語：日本語   出版者・発行元：(公社)日本矯正歯科学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

These results suggest that vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress.

DOI： 10.1016/j.archoralbio.2009.02.006

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

These results suggest that the self-reported questions are useful for screening of periodontitis in 50- to 59-yr-old Japanese workers.

DOI： 10.1539/joh.L8108

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Toothbrushing promoted healing of periodontal lesions, decreased serum lipopolysaccharide concentration and suppressed liver injury in a rat periodontitis model.

DOI： 10.1080/00016350902794818

PubMed

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Increased levels of oxidative stress due to excessive production of reactive oxygen species are involved in the pathogenesis of periodontitis. Studies suggest a negative association between plasma vitamin C level and the severity of periodontitis. We hypothesized that increases in plasma vitamin C levels after vitamin C intake might clinically reduce gingival oxidative stress in a rat periodontitis model. A ligature was placed around rat mandibular molars for 4 weeks to induce periodontitis, and the rats were then given drinking water with or without 1 g/L vitamin C for 2 weeks after the ligature was removed. The periodontitis-induced rats showed a 149% increase in 8-hydroxydeoxyguanosine level and a 40% decrease in reduced:oxidized glutathione ratio in gingival tissue. Vitamin C intake induced a 175% increase in plasma vitamin C level, resulting in an improvement in the gingival 8-hydroxydeoxyguanosine level (decreased) and in the reduced:oxidized glutathione ratio (increased). Furthermore, in ligature-induced periodontitis lesions, gene expression encoding inflammation, including interleukin-1 alpha and interleukin-1 beta, was more than twofold down-regulated by vitamin C intake. The results suggest that systemic administration of vitamin C could be clinically beneficial in improving periodontitis-induced oxidative stress by down-regulating inflammatory gene expression.

DOI： 10.1016/j.freeradbiomed.2008.09.040

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   掲載種別：研究論文（学術雑誌）  

In the rat model, ligature-induced periodontitis increased plasma lipid peroxide, decreased the hepatic GSH/GSSG ratio and augmented ethanol-induced lipid peroxidation in the liver.

DOI： 10.1016/j.archoralbio.2008.05.015

PubMed

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

記述言語：日本語   出版者・発行元：特定非営利活動法人 日本歯周病学会  

DOI： 10.14833/amjsp.2008s.0.95.0

CiNii Article

researchmap

記述言語：日本語   出版者・発行元：特定非営利活動法人 日本歯周病学会  

DOI： 10.14833/amjsp.2008s.0.52.0

CiNii Article

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：特定非営利活動法人 日本歯周病学会  

DOI： 10.14833/amjsp.2007f.0.130.0

CiNii Article

researchmap

記述言語：日本語   出版者・発行元：特定非営利活動法人 日本歯周病学会  

DOI： 10.14833/amjsp.2007s.0.106.0

CiNii Article

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

出版者・発行元：特定非営利活動法人 日本歯周病学会  

DOI： 10.14833/amjsp.2006f.0.115.0

CiNii Article

researchmap

出版者・発行元：特定非営利活動法人 日本歯周病学会  

DOI： 10.14833/amjsp.2006f.0.44.0

CiNii Article

researchmap

掲載種別：研究論文（学術雑誌）  

Scopus

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：医歯薬出版(株)  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

記述言語：日本語   出版者・発行元：(公社)日本歯科医師会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J01095&link_issn=&doc_id=20020402050042&doc_link_id=%2Fcp9perlo%2F2002%2F0044s2%2F042%2F0095-0095%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp9perlo%2F2002%2F0044s2%2F042%2F0095-0095%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J01095&link_issn=&doc_id=20010927130084&doc_link_id=%2Fcp9perlo%2F2001%2F0043s2%2F084%2F0145-0145%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp9perlo%2F2001%2F0043s2%2F084%2F0145-0145%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2001&ichushi_jid=J01095&link_issn=&doc_id=20010927130106&doc_link_id=%2Fcp9perlo%2F2001%2F0043s2%2F106%2F0168-0168%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp9perlo%2F2001%2F0043s2%2F106%2F0168-0168%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

総ページ数：ix, 260p   記述言語：日本語

CiNii Books

researchmap

総ページ数：ix, 260p   記述言語：日本語

CiNii Books

researchmap

researchmap

総ページ数：xii, 370 p.   記述言語：英語

CiNii Books

researchmap

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本未病学会  

researchmap

記述言語：英語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年医学会  

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年医学会  

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本疫学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年歯科医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本老年医学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本摂食嚥下リハビリテーション学会  

researchmap

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2022&ichushi_jid=J03152&link_issn=&doc_id=20220610060001&doc_link_id=%2Fcb5dvsph%2F2022%2F002601%2F001%2F0003-0009%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcb5dvsph%2F2022%2F002601%2F001%2F0003-0009%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：日本語   出版者・発行元：(一社)日本疫学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(公社)日本歯科医師会  

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語  

DOI： 10.3390/ijerph17093034

Scopus

PubMed

researchmap

J-GLOBAL

researchmap

J-GLOBAL

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：岡山歯学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00440&link_issn=&doc_id=20181113220005&doc_link_id=%2Fdk1dehea%2F2018%2F006804%2F005%2F0231-0237%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2018%2F006804%2F005%2F0231-0237%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語   出版者・発行元：Elsevier Ltd  

DOI： 10.1016/j.archoralbio.2018.02.021

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語   出版者・発行元：Springer Netherlands  

DOI： 10.1007/s12223-018-0596-1

Scopus

PubMed

researchmap

記述言語：英語   出版者・発行元：Elsevier Ltd  

DOI： 10.1016/j.archoralbio.2017.12.007

Scopus

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

DOI： 10.5834/jdh.68.1_9

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00440&link_issn=&doc_id=20180207240002&doc_link_id=%2Fdk1dehea%2F2018%2F006801%2F002%2F0009-0014%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdk1dehea%2F2018%2F006801%2F002%2F0009-0014%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

記述言語：英語  

DOI： 10.1177/1359105316668668

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1371/journal.pone.0188171

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語  

DOI： 10.1016/j.archoralbio.2017.06.025

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語  

DOI： 10.1016/j.archoralbio.2017.05.004

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本歯科衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語  

DOI： 10.1371/journal.pone.0179298

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3390/ijms18061263

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan-Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C-reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19-9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000-1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15-5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

DOI： 10.3892/mco.2017.1220

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語  

DOI： 10.3390/nu9010064

Web of Science

Scopus

PubMed

researchmap

DOI： 10.5834/jdh.67.1_11

researchmap

記述言語：英語  

DOI： 10.1155/2017/9547956

Web of Science

Scopus

PubMed

researchmap

DOI： 10.5834/jdh.67.1_29

researchmap

記述言語：英語  

DOI： 10.1186/s12903-016-0322-9

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3390/ijms17111907

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3892/or.2016.5021

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1111/jcpe.12536

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：日本口臭学会  

researchmap

記述言語：英語  

DOI： 10.1093/ajh/hpv117

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3390/nu8030114

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1093/ajh/hpv117

Web of Science

PubMed

researchmap

記述言語：日本語   出版者・発行元：(公社)日本化学療法学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本感染症学会  

researchmap

researchmap

J-GLOBAL

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語  

DOI： 10.3390/ijms160921294

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1111/jre.12233

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3390/ijerph120809119

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1902/jop.2015.150006

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3109/00016357.2014.968870

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.2188/jea.JE20140180

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(NPO)日本歯周病学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：日本語   出版者・発行元：(一社)日本口腔衛生学会  

researchmap

記述言語：英語  

DOI： 10.1111/jre.12183

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1590/1678-775720140223

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.1111/jcpe.12476

Scopus

PubMed

researchmap

researchmap

記述言語：日本語   出版者・発行元：厚生労働統計協会  

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2015373805

記述言語：日本語   出版者・発行元：日本口臭学会  

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2015287943

記述言語：日本語   出版者・発行元：有限責任中間法人日本口腔衛生学会  

生活習慣病予防はわが国喫緊の課題である.生活習慣病スクリーニングを受ける機会の提供,生活習慣病に関する情報提供,および,医療機関への適切な受診勧奨等が生活習慣病予防のために重要である.本研究では,これらを実施する場の一つとして歯科を捉え,その可能性を検討することを目的とした.簡易な血液検査による生活習慣病スクリーニングを歯周病メインテナンス期患者に行い,分析した.2014年1月から7月に岡山大学病院予防歯科外来を受診した歯周病メインテナンス期患者63名(男性22名,女性41名,平均年齢65.9±6.7歳)を対象に,自己記入式質問紙調査と指尖血の採取を行い,肝疾患,高脂血症(脂質異常症),腎疾患,痛風,糖尿病前症,および糖尿病の疑いの有無を判定した.過去1年間の医療機関受診歴を53名(84.1%)が有していた.過去1年間に肝疾患,高脂血症,腎疾患,痛風,および糖尿病の診断のある者は,それぞれ3名,14名,2名,1名,3名おり,各々の分析から除外された.血液検査の結果,肝疾患,高脂血症,腎疾患,痛風,糖尿病前症,および糖尿病の疑いは,それぞれ対象者の16.7%,34.7%,16.4%,1.6%,46.7%,および6.7%に認められた.医療機関受診歴を有する者の多さに関わらず,生活習慣病予防が必要と思われる者の割合は十分多かった.歯科の場において,簡易な生活習慣病スクリーニングを行い,医療機関への受診勧奨等を行う流れを作ることで,国民の生活習慣病予防の一端を担えるかもしれない.

DOI： 10.5834/jdh.65.4_354

CiNii Article

CiNii Books

researchmap

その他リンク： http://search.jamas.or.jp/link/ui/2015395384

記述言語：英語  

DOI： 10.3390/antiox4030513

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(株)ヒョーロン・パブリッシャーズ  

researchmap

記述言語：英語  

DOI： 10.2169/internalmedicine.54.4889

Web of Science

Scopus

PubMed

researchmap

J-GLOBAL

researchmap

記述言語：英語  

DOI： 10.3390/nu6125756

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語  

DOI： 10.1002/oby.20842

Web of Science

Scopus

PubMed

researchmap

記述言語：英語  

DOI： 10.3390/nu6104476

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：日本公衆衛生学会  

researchmap

記述言語：英語  

DOI： 10.1186/1476-511X-13-144

Web of Science

Scopus

PubMed

researchmap

記述言語：日本語   出版者・発行元：(一社)歯科基礎医学会  

researchmap

記述言語：英語  

DOI： 10.1111/jcpe.12273

Web of Science

Scopus

PubMed

researchmap