Language：English   Publishing type：Research paper (scientific journal)  

OBJECTIVE: Near-infrared photoimmunotherapy (NIR-PIT) has been approved by the Japanese national health insurance for approximately five years, and clinical experience has steadily accumulated. However, reports analyzing treatment outcomes and pain-related factors remain limited. This study aimed to identify predictors of therapeutic response and pain following NIR-PIT. METHODS: This retrospective cohort study included 25 patients who underwent NIR-PIT for head and neck cancer between January 2021 and June 2025. Lesion diameter and thickness were evaluated in relation to complete response (CR), and the frequency and predictors of post-treatment pain were assessed. RESULTS: Among 22 evaluable patients, eight achieved CR. Lesions with a shorter longest diameter and thinner thickness were significantly associated with higher CR rates (p = 0.011 and p = 0.024). Moderate-to-severe pain (Numerical Rating Scale ≥4) occurred in 18 of 48 treatment cycles (37.5%) but was significantly less frequent in patients with a history of reconstructive surgery (p = 0.017). CONCLUSIONS: NIR-PIT demonstrated particularly favorable efficacy for short, thin lesions, suggesting that early introduction of treatment may be associated with improved therapeutic outcomes. A history of reconstructive surgery was associated with reduced post-treatment pain, highlighting the importance of individualized treatment and pain management strategies in head and neck cancer patients undergoing NIR-PIT.

DOI： 10.1016/j.amjoto.2026.104848

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PURPOSE: Near-infrared photoimmunotherapy has been approved in Japan for unresectable locally advanced or recurrent head and neck cancer. While this therapy theoretically induces selective necrosis of epidermal growth factor receptor-expressing tumor cells following administration of cetuximab sarotalocan sodium and irradiation with 690-nm light, residual disease is not uncommon in clinical practice. The mechanisms underlying such persistence remain poorly understood. METHODS: We examined two patients with head and neck squamous cell carcinoma who underwent salvage resection due to residual disease after four cycles of near-infrared photoimmunotherapy. Resected specimens were subjected to histopathological evaluation, including immunohistochemistry for epidermal growth factor receptor, cluster of differentiation 8, programmed cell death protein 1, and forkhead box P3 proteins. RESULTS: In both cases, residual tumor cells were predominantly localized in the superficial mucosal layers, while deeper layers were replaced by fibrosis. All residual tumors retained expression of epidermal growth factor receptor. Lymphocytic infiltration was sparse, with scattered cluster of differentiation 8-positive cells but few programmed cell death protein 1-positive or forkhead box P3-positive lymphocytes. These findings suggest that the tumor microenvironment surrounding residual tumors may have been unfavorable for the induction of robust antitumor immune responses. CONCLUSION: Residual tumors after near-infrared photoimmunotherapy can occur despite adequate laser irradiation and epidermal growth factor receptor expression. Our observations imply that insufficient immune activation within the tumor microenvironment may contribute to treatment resistance. Further characterization of the post-photoimmunotherapy tumor microenvironment will be essential to better understand treatment mechanisms and to optimize therapeutic efficacy.

DOI： 10.1016/j.pdpdt.2026.105422

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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

Near-infrared photoimmunotherapy (NIR-PIT) is a novel therapeutic approach that targets epidermal growth factor receptor (EGFR). In NIR-PIT, administration of cetuximab sarotalocan sodium is followed by laser irradiation of the affected area, which theoretically should induce tumor cell death. However, residual tumors are occasionally observed. This study investigated factors that influence the therapeutic efficacy of NIR-PIT in cases of recurrence of cancer at the base of the tongue. Six patients undergoing 11 treatment cycles were analyzed, focusing on the puncture interval of cylindrical diffusers and the expression of EGFR in tumors. The results demonstrated that a puncture interval of ≤12 mm significantly enhanced therapeutic efficacy, with one case achieving complete response. EGFR expression was positive in all cases and expression score showed no significant change between before and after treatment. These findings suggest that puncture interval plays a critical role in therapeutic outcomes, whereas EGFR expression may not directly influence treatment efficacy.

DOI： 10.1016/j.pdpdt.2025.104719

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OBJECTIVES: Although several studies have reported the benefits of intratympanic steroid injection (ISI) in the treatment of idiopathic sudden sensorineural hearing loss (SSHL), its effectiveness remains controversial. The purpose of this study was to evaluate the efficacy of ISI as a salvage therapy for SSHL and identify factors associated with treatment outcomes. METHODS: We retrospectively reviewed the medical records of 119 patients who received systemic steroids for the treatment of SSHL at our hospital between 2014 and 2023. Of the 76 patients who were not complete recovery after systemic administration, 56 were treated using ISI as a salvage therapy. RESULTS: Among the 76 patients who were not complete recovery after systemic administration, a short period between onset and systemic steroid administration (<4 days) showed favorable treatment effects (p = 0.020). We focused on the 56 patients treated using salvage ISI therapy to evaluate the prognostic factors affecting the efficacy of ISI therapy. The mean hearing loss values were 84.1 dB at the initial visit, 70.7 dB on completion of systemic steroid administration, and 61.8 dB at the final evaluation after ISI. In the univariate analysis, patients who received ISI <23 days after SSHL onset, those who had a hearing loss of ≥60 dB at the initial visit, and those who presented with vertigo at the initial presentation had better hearing recovery with ISI than those who did not (p < 0.01, p = 0.021, and p = 0.052, respectively). Multivariate analysis revealed that a period of <23 days from onset to salvage therapy was independently associated with favorable ISI effects (p = 0.032). CONCLUSIONS: In patients with SSHL, the introduction of salvage ISI therapy <23 days after onset contributes to good hearing recovery. In addition, salvage ISI therapy might be an optional treatment for patients whose hearing loss is ≥60 dB at the initial visit or who present with vertigo at the initial examination.

DOI： 10.1016/j.anl.2025.03.006

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DOI： 10.1016/j.anl.2025.04.001

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BACKGROUND: In parotid tumors, preoperative differential diagnosis between pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) remains challenging. OBJECTIVES: The present study aimed to evaluate the clinical characteristics of CXPA and PA and to identify factors associated with the differential diagnosis of these conditions. MATERIAL AND METHODS: We reviewed the medical records of 6 CXPA and 127 PA patients treated surgically at our institution between 2008 and 2024. RESULT: Univariate analysis revealed significant differences in spontaneous pain (p = .044), facial nerve palsy (p = .045), and subjective enlargement (p < .01) between the CXPA and PA patients. Magnetic resonance imaging (MRI) revealed that the proportions of masses with ill-defined margins, localization in the deep lobe, and low apparent diffusion coefficient (ADC) were significantly higher in patients with CXPA than in those with PA (p < .01, p = .048, and p < .01, respectively). Multivariate analysis identified that spontaneous pain and masses with ill-defined margins were associated with CXPA (p = .047 and p = .013, respectively). CONCLUSION: Spontaneous pain and masses with ill-defined margins could be suggestive of CXPA rather than PA. Low ADC levels indicate the possibility of CXPA.

DOI： 10.1080/00016489.2025.2480687

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OBJECTIVE: An optimal surgical approach for intermediate-risk papillary thyroid cancer (PTC) has not yet been established. The surgical procedure should be determined based on treatment outcomes and postoperative complications. This study aimed to evaluate appropriate surgical strategies for patients with intermediate-risk PTC by comparing treatment outcomes and postoperative complications following total thyroidectomy and lobectomy. METHODS: This retrospective analysis was conducted on 123 patients with intermediate-risk PTC treated in our department between January 2008 and December 2022. The risk of PTC was classified according to the 2024 Guidelines for the Clinical Treatment of Thyroid Nodules from the Japan Association of Endocrine Surgery. RESULTS: Of the 123 patients, 27 underwent total thyroidectomy, and 96 underwent lobectomy. No significant differences were observed between the two surgical groups in terms of survival or recurrence rates. None of the patients showed bilateral recurrent laryngeal nerve (RLN) palsy postoperatively. Postoperative unilateral RLN palsy occurrence differed significantly between the total thyroidectomy and lobectomy groups, with five cases in each (5.2 and 18.5 %, respectively; p = 0.04). Permanent hypoparathyroidism was observed in two patients (7.4 %) in the total thyroidectomy group. Postoperative hypothyroidism developed in 42 (43.8 %) lobectomy cases, with 32 requiring the administration of levothyroxine therapy. A significant association was observed between preoperative thyroid-stimulating hormone (TSH) levels (≥2.0 μIU/mL) and postoperative hypothyroidism (p < 0.001). CONCLUSION: No significant difference in treatment outcomes was observed between patients with intermediate-risk PTC who underwent total thyroidectomy and those who underwent lobectomy. In cases with preoperative TSH levels ≥2.0 μIU/mL, total thyroidectomy may be a more suitable approach, given the increased likelihood of requiring postoperative levothyroxine administration following lobectomy.

DOI： 10.1016/j.anl.2024.12.005

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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No previous study has published magnetic resonance imaging (MRI) findings for a subglottic pleomorphic adenoma. Here, we describe the case of a 62-year-old man with a subglottic pleomorphic adenoma. Endoscopic findings revealed a smooth-surfaced tumor arising from the subglottic posterior wall. MRI revealed the lesion as an isointense region on T1-weighted images, which was homogeneously enhanced. This lesion showed a heterogeneously hyperintense region on T2-weighted images. Diffusion-weighted imaging (DWI) showed slightly high intensity in the same area, with a normal or only slightly high apparent diffusion coefficient (ADC). Laryngomicrosurgery was performed for transoral excision of the subglottic tumor, resulting in a postsurgical diagnosis of pleomorphic adenoma.

DOI： 10.18926/AMO/67549

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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This report describes a case of an electric toothbrush head being retained between the floor of the mouth and the submandibular gland following a fall. Computed tomography imaging is recommended in cases of oral cavity damage to assess tissue damage and ascertain the position of the foreign body concerning blood vessels.

DOI： 10.1002/ccr3.8987

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Aims: Among primary thyroid lymphomas (PTLs), diffuse large B-cell lymphoma (DLBCL) has a poorer prognosis than other indolent lymphomas such as mucosa-associated lymphoid tissue (MALT) or follicular lymphoma (FL). However, the clinical differences between DLBCL and indolent lymphoma remain unclear. Therefore, this retrospective study on PTL was aimed at investigating the clinical differences between DLBCL and indolent lymphomas and identifying the factors differentiating DLBCL from indolent lymphomas. Materials and Methods: Medical records of 28 patients diagnosed with PTL and treated at our institution between 2005 and 2022 were retrospectively analyzed. Data on the following clinical variables were extracted: sex, age, symptoms (pain and dysphagia), ultrasonographic appearance patterns, the presence of airway stenosis on computed tomography and laryngeal endoscopy, blood test results, disease stage, and pathological diagnosis. Results: In all, 13 patients were histologically diagnosed with DLBCL, 12 with MALT lymphoma, and 3 with FL. Significant differences in disease-specific survival rates were evident between the DLBCL and indolent lymphoma groups (68.2 vs 100%, P = .043). High lactate dehydrogenase levels (>230 U/mL) and airway stenosis were observed only in patients with DLBCL. Multivariate analysis identified that the presence of a linear echoic strand pattern and the absence of an echoic nodular pattern on ultrasound were independently associated with DLBCL (P = .0497 and .012, respectively). Conclusion: DLBCL can cause airway stenosis. The linear echogenic strand pattern and the absence of a nodular pattern should be recognized as predictive factors of DLBCL.

DOI： 10.1177/01455613231218130

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In Japan, near-infrared photoimmunotherapy (NIR-PIT) was introduced in 2021 as a treatment option for unresectable recurrent head and neck cancer. The treatment targets the epidermal growth factor receptor (EGFR), which is overexpressed in 80-90 % of head and neck squamous cell carcinoma (HNSCC). NIR-PIT should theoretically show therapeutic efficacy if EGFR is expressed, even in nonsquamous cell carcinomas (non-SCC). To the best of our knowledge, there are no case reports of NIR-PIT for non-SCC. We performed NIR-PIT in a patient with non-SCC of the head and neck region. After performing two NIR-PIT treatments, small free clusters of residual tumor cells were observed. Immunostaining in this specimen revealed EGFR expression in residual tumor cells. The residual tumor cells had been irradiated sufficiently to achieve necrosis. It is suggested that not only laser irradiation and expression of EGFR but also other factors are involved in the efficacy of this treatment. Further investigation for these other factors is warranted.

DOI： 10.1016/j.anl.2023.09.006

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DOI： 10.5631/jibirin.116.881

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DOI： 10.5631/jibirin.116.573

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We describe the case of a 51-year-old woman with immunoglobulin G4-related disease (IgG4-RD) diagnosed using lip biopsy. She reported having bilateral submandibular nodules for a month. Magnetic resonance imaging showed diffuse swelling in the bilateral submandibular glands (SMGs), suggesting inflammatory changes. Laboratory data revealed an elevated level of serum IgG4. Fine needle aspiration cytology of the SMG showed a considerable number of lymphocytes with degeneration but did not demonstrate specific findings for a definitive diagnosis of IgG4-RD. Lip biopsy was performed, and a biopsy specimen from the labial salivary gland showed abundant lymphoplasmacytic infiltration with a large number of IgG4-positive cells. The patient was diagnosed with IgG4-RD based on histological and laboratory findings. Findings of further examinations revealed that the patient had autoimmune pancreatitis, confirming our diagnosis. Four months after prednisolone administration, improvement of the submandibular and pancreatic lesions was observed. One year after the initial presentation, the serum IgG4 level was normalized. In cases of IgG4-RD with salivary gland involvement, lip biopsy might be one of the options for the histological diagnosis of IgG4-RD.

DOI： 10.1177/0145561320971932

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Methotrexate-associated lymphoproliferative disorders (MTX-LPD) frequently involve the extranodal organs throughout the body. Among the extranodal occurrences of MTX-LPD, pulmonary involvement is most frequent. In contrast, there are only a few reports of MTX-LPD in the nasal cavity or paranasal sinuses. Moreover, there are no previous reports of MTX-LPD mimicking granulomatosis with polyangiitis (GPA) in imaging examinations. We describe a case of a 53-year-old woman with MTX-LPD mimicking GPA in the nasal cavity and lungs. She complained of left nasal obstruction and discharge, general fatigue, and continual fever for 2 months. The patient had been diagnosed with rheumatoid arthritis and received methotrexate (MTX) for over 10 years. Contrast-enhanced computed tomography revealed unenhanced masses in the nasal cavity and multiple masses with cavitary changes in the bilateral lungs, suggesting GPA. However, histological examination of the nasal lesion and a history of MTX treatment indicated a diffuse large B-cell lymphoma type MTX-LPD. Two weeks after MTX withdrawal, prominent improvements in both lesions were observed. Complete regression of the nasal lesion was observed 3 months after discontinuation of MTX. Thus, MTX-LPD may mimic GPA in imaging examinations.

DOI： 10.1177/0145561320970685

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DOI： 10.1097/MAO.0000000000003220

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OBJECTIVES: Sialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses. METHODS: Medical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue. RESULTS: Eight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39-74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence. CONCLUSION: Laryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses.

DOI： 10.1016/j.anl.2020.07.017

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Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p = .026) and laryngeal dysfunction free rate (p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.

DOI： 10.1080/00016489.2020.1767303

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Igaku-Shoin Ltd  

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.113.285

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Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

DOI： 10.1080/00016489.2019.1633019

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BACKGROUND: Traumatic tympanic membrane perforation (TTMP) is usually managed conservatively because most close spontaneously within a few months. Nevertheless, spontaneous closure of TTMP during long-term observation has not been well described in the literature. OBJECTIVES: The present study investigated factors associated with spontaneous closure of TTMP, and the characteristics of cases exhibiting spontaneous closure following long-term observation. MATERIALS AND METHODS: The medical records of 40 patients with TTMP who visited the authors' hospital were retrospectively reviewed. RESULTS: Spontaneous closure was observed in 27 (67.5%) patients. The healing period was <2 weeks in 6 cases, <4 weeks in 9, <3 months in 5, <6 months in 3, and ≥6 months in 4. All four cases in which spontaneous closure took ≥6 months exhibited a sign of spontaneous closure at 6 months following injury. Perforation in contact with the malleus was associated with a lower frequency of spontaneous closure. CONCLUSIONS AND SIGNIFICANCE: In TTMP, surgery should be considered in patients who exhibit perforation in contact with the malleus. However, it has also been suggested that long-term observation may be a viable treatment option when a sign of spontaneous closure is observed within 6 months following injury.

DOI： 10.1080/00016489.2019.1592225

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Igaku-Shoin Ltd  

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BACKGROUND: Regarding prognostic factors of acute rhinosinusitis (ARS) with orbital complications, there are few studies including adult cases. OBJECTIVES: The present study aims to delineate prognostic factors of ARS with orbital complications. MATERIAL AND METHODS: We conducted a retrospective analysis of medical records of 21 patients (6 pediatric and 15 adult patients) with ARS with orbital complications. The duration of recovery was defined as the time from initial diagnosis to complete resolution of local findings and all symptoms. Orbital complications due to postoperative cysts or mycosis were excluded. RESULTS: Twenty-one patients comprised 11 males and 10 females. Chandler's classification showed group I in 4, group II in 8, and group III in 9. None of six pediatric patients required any surgical intervention, whereas five adult patients (23.8%) underwent surgical intervention. The average period of recovery was 8.1 days. In univariate analysis, the duration of recovery was significantly longer among adult cases (p < .01) and cases with Chandler's groups II-III (p = .019). In multivariate analysis, adult patients had a significantly longer duration of recovery than pediatric patients (p = .027). CONCLUSION AND SIGNIFICANCE: The present study suggested that ARS with orbital complications may have prolonged clinical course in adults.

DOI： 10.1080/00016489.2018.1539516

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BACKGROUND: Baker's rhinitis is a kind of occupational allergic rhinitis mainly caused by intranasal exposure to wheat and/or rye flour in bakery workers. Continuous exposure to flour may induce the onset of asthma in these patients. METHOD: We experienced a case of 34-year-old male with baker's rhinitis without asthma, and investigated responses of IgE and peripheral blood mononuclear cells (PBMCs) to flour extracts used in the bakery in practice. RESULT: In the immunoblotting, the patient's IgE reacted with 18 and 30kDa molecules in the extracts of 6 flours used in the bakery. The patient's PBMC produced a substantial amount of IL-5 and IL-13 in response to these flour extracts. CONCLUSION: It is suggested that water/salt soluble components of wheat flour selectively induce type 2 cytokines production in baker's rhinitis.

DOI： 10.15036/arerugi.68.35

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J00009&link_issn=&doc_id=20190208340007&doc_link_id=1390845713054037760&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390845713054037760&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.112.99

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OBJECTIVES: We reviewed surgical results of canal wall-down tympanoplasty (CWDT) with soft posterior meatal wall reconstruction (SWR) for acquired cholesteatoma (AC), and identified factors associated with surgical outcomes. METHODS: Results from 119 ears with AC (pars flaccida, n = 99; pars tensa, n = 20) that underwent CWDT with SWR were retrospectively reviewed. We defined postoperative balloon-like retraction (PBR) with web formation, which needed reoperation to clean accumulated cerumen, as postoperative deep retraction pocket (PDRP). RESULTS: Residual cholesteatoma was found in 11 ears (9.2%). Seven residual cholesteatomas were treated with outpatient operation. Seven ears (5.9%) showed PDRP. A transcanal approach was applied to all PDRPs. Postoperative mastoid reaeration was observed in 57 ears (47.9%). No factors significantly associated with residual cholesteatoma or PDRP were identified. The frequency of postoperative mastoid reaeration was significantly higher among cases with young age (<50 years), stage I cholesteatoma, or type I ossiculoplasty. CONCLUSION: CWDT with SWR showed low rates of residual cholesteatoma or postoperative deep retraction pocket (PDRP). Most residual cholesteatomas and PDRPs could be dealt with using a minimally invasive procedure. Young age, stage I cholesteatoma, and type I ossiculoplasty were associated with postoperative mastoid reaeration. This procedure seems fully feasible for surgical treatment of AC.

DOI： 10.1080/00016489.2018.1439593

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OBJECTIVES: Croup, or laryngotracheobronchitis, is a common disease in childhood. On the other hand, to our knowledge, there are only 14 cases in six English literatures describing adult croup (AC). The clinical features of AC have not been well known. METHODS: We conducted a retrospective analysis of medical records of 18 patients with AC during the period from 2008 to 2016. RESULTS: None of the 18 patients required an urgent airway intervention. Univariate analysis indicated that the duration of symptoms was significantly longer in patients with cough (p < .01) and younger patients (age < 60, p = .037). The duration of subglottic edema was significantly longer in female (p = .035), patients with high levels of CRP (≥1 mg/dL, p = .049), and patients with cough symptom (p = .035). CONCLUSIONS: Female, young age (<60 years), the symptom of cough, and high levels of CRP should be recognized as signs of prolonged AC. It is important to confirm the diagnosis of AC by laryngoscopic examination, which also help to avoid airway intervention.

DOI： 10.1080/00016489.2017.1422140

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Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：Society of Practical Otolaryngology  

DOI： 10.5631/jibirin.111.743

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Language：Chinese   Publishing type：Research paper (scientific journal)   Publisher：Igaku-Shoin Ltd  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

43歳男性。口腔出血、呼吸苦を主訴に近医を受診、右扁桃周囲炎が疑われ当科へ紹介となった。臨床経過および頸部造影CT所見より、本症例は両側口蓋扁桃周囲膿瘍に伴う扁桃出血(STH:Spontaneous Tonsillar Hemorrhage)と診断され、治療は右口蓋扁桃の出血は既に自然止血していたため止血処置が不要であり、扁桃周囲膿瘍に対してだけ切開排膿を行った。開放膿からはα-Streptococcusが検出され、排膿術後はセフォゾプランとヒドロコルチゾンコハク酸エステルナトリウムの投与が行われた。その結果、症状、局所所見の改善が認められた。

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12歳男児。鼻閉を主訴に近医を受診し、急性副鼻腔炎の診断でクラリスロマイシンを処方され、内服終了2日後より頭痛が出現した。セフジトレンピボキシル(CDTR-PI)、クラブラン酸カリウム・アモキシシリン水和物(CVA/AMPC)を処方されたが頭痛は増悪し、40度台の発熱、開口障害が出現した。初診時は開口1.5横指で、右蝶形骨洞自然口付近の膿性鼻汁を認めた。造影CT所見で右側頭下窩から副咽頭間隙にかかる炎症の進展を認め、側頭下窩の膿瘍形成が疑われた。血液検査では炎症反応が認められた。以上より、側頭下窩に波及した右蝶形骨洞炎と診断し、ドレナージ目的に内視鏡下鼻内副鼻腔手術を行った。洞内から多量の白色膿汁が流出し、膿汁からはHaemophilus influenza BLNARが検出された。CDTR-PI、CVA/AMPCは無効であったため、術当日よりカルバペネム系抗菌薬、CLDMを併用投与し、開口障害は消失した。術後7ヵ月時点で蝶形骨洞炎の再燃は認めない。

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：(公社)日本小児科学会  

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Language：Japanese   Publisher：(公社)日本小児科学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：日本耳鼻咽喉科免疫アレルギー感染症学会  

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J-GLOBAL

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Language：Japanese   Publisher：(株)医学書院  

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Language：Japanese   Publisher：(一社)日本内分泌外科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J07222&link_issn=&doc_id=20241106290013&doc_link_id=10.11226%2Fojjaes.41.3_210&url=https%3A%2F%2Fdoi.org%2F10.11226%2Fojjaes.41.3_210&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(株)羊土社  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J02661&link_issn=&doc_id=20240712380009&doc_link_id=10.14821%2Fstomatopharyngology.37-134&url=https%3A%2F%2Fdoi.org%2F10.14821%2Fstomatopharyngology.37-134&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Language：Japanese   Publisher：(公社)日本小児科学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

症例は63歳女性で、左水様性鼻汁、頭痛、発熱を主訴に、前医にて細菌性髄膜炎を伴う髄液鼻漏として抗菌薬投与が行われた。治療により髄膜炎は軽快したが、髄液鼻漏は腰椎ドレーン留置後も軽減せず、当院紹介となった。前医で施行された脳槽シンチグラムの再検および受診時CT・MRI所見から斜台部からの髄液鼻漏と診断し、内視鏡下に骨病変部の切除と有茎鼻中隔粘膜弁を用いて硬膜の修復を行った。病理組織学的に斜台部の骨欠損部に存在した腫瘤性組織に悪性所見はみられず、特発性髄液鼻漏と診断した。術後2年3ヵ月の時点で鼻中隔粘膜弁は安定しており、髄液鼻漏の再発は認めなかった。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00580&link_issn=&doc_id=20230907280008&doc_link_id=10.5631%2Fjibirin.116.881&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.116.881&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：(株)医学書院  

67歳男。4年前から右鼻腔入口部の腫瘤を自覚し、腫瘤が増大したため近医皮膚科を受診し、広基性の皮膚結節を指摘され、精査加療目的で当科に紹介された。CT検査で右鼻前庭部に内部がほぼ均一で中間的な軟部濃度を呈する長径2cm程度の腫瘤影を認めた。MRIで同部位に18×14×12mmのT1強調像で筋と等信号、T2強調像で高信号を呈する境界明瞭な腫瘤影を認めた。病変の局在と画像所見から鼻前庭嚢胞を疑った。手術治療を希望したため腫瘤摘出術を施行し、摘出標本の病理組織所見から静脈奇形と診断された。

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

症例は77歳男性で、左鼻出血、鼻根部痛を主訴に当科を受診した。CTで鼻中隔上方に腫脹を認め、MRIではT2強調像および拡散強調像で鼻中隔に腫瘤状の高信号域がみられた。鼻中隔粘膜下組織の炎症や腫瘍性病変を疑い、局所麻酔下に生検を実施し、その後の精査で鼻中隔に限局する再発性多発軟骨炎の診断に至った。病変が鼻中隔に限局し、自覚症状が消失していたことから、経過観察したところ、鼻中隔の腫脹は生検後3週間で消失し、その後は5年間にわたり症状の再燃は認めていない。

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00580&link_issn=&doc_id=20230612150011&doc_link_id=10.5631%2Fjibirin.116.573&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.116.573&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(株)医学書院  

症例は64歳女性で、鼻中隔由来の腺様嚢胞癌に対する重粒子線治療の既往が有った。治療後10年9ヵ月経過して鼻中隔に隆起性病変が出現し、生検で腺様嚢胞癌の再発を示唆する所見を認めた。MRIにて鼻中隔に限局する直径1.5cmの結節様構造が存在し造影効果を認め、PET/CTにて遠隔転移所見は認めなかったため、腺様嚢胞癌の局所再発と診断した。全身麻酔下、内視鏡下に電気メスを用いて鼻中隔腫瘍性病変、両側鼻中隔粘膜、鼻中隔軟骨、鋤骨および篩骨垂直板を合併切除した。病理組織学的に篩状腺様嚢胞癌と診断し、切除断端は陰性であった。術後2年以上経過して明らかな再発は認めていない。

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Language：Japanese   Publisher：日本小児耳鼻咽喉科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02235&link_issn=&doc_id=20221227010008&doc_link_id=10.11374%2Fshonijibi.43.313&url=https%3A%2F%2Fdoi.org%2F10.11374%2Fshonijibi.43.313&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Language：Japanese   Publisher：(一社)日本小児感染症学会  

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Language：Japanese   Publisher：(株)医学書院  

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Language：Japanese   Publisher：(株)医学書院  

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Language：Japanese   Publisher：日本口腔・咽頭科学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(公社)日本小児科学会  

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Language：Japanese   Publisher：(公社)日本小児科学会  

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Language：Japanese   Publisher：日本小児耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本頭頸部癌学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：日本小児耳鼻咽喉科学会  

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(NPO)日本気管食道科学会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J01054&link_issn=&doc_id=20200820370003&doc_link_id=%2Fea4broes%2F2020%2F007104%2F003%2F0306-0310%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fea4broes%2F2020%2F007104%2F003%2F0306-0310%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Language：Japanese   Publisher：(一社)日本内分泌外科学会  

72歳女性。健診の胸部単純写真にて縦隔の異常陰影を指摘され、近医の内科を受診、近医では胸部単純写真を11年前に、また8年前からは年1回撮影しており、画像所見上、11年前気管の偏位はわずかであった。だが、縦隔の腫瘤影は徐々に気管分岐部付近まで下降した後、側方への増大が認められた。精査目的で当科へ紹介された際、CTでは甲状腺右葉から縦隔へと進展する境界明瞭な7cm大の腫瘤が確認され、腫瘤影の下端は大動脈弓下端レベル、気管後方まで及んでいた。以上、これらの所見を踏まえて、本症例は縦隔内甲状腺腫が疑われ、頸部アプローチで腫瘍摘出術が行なわれた。その結果、病理診断は腺腫様甲状腺腫であり、術後は反回神経麻痺などの合併症を認めず、経過良好であった。

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Language：Japanese   Publisher：(一社)日本めまい平衡医学会  

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(株)医学書院  

69歳男。呼吸苦を主訴とした。喉頭癌に対する放射線治療歴があり、感冒症状出現後、10日目より呼吸苦が出現した。初診時の喉頭内視鏡所見では両側の声帯は副正中位で固定しており、吸気時の声帯の開大は乏しく、輪状後部の粘膜に白苔の付着を認めた。画像検査上、中枢および頭頸部領域に明らかな異常はなく、ウイルス性の迷走神経麻痺の可能性を疑い、血清抗体価の結果を待たずに抗ウイルス薬投与を開始した結果、呼吸状態は改善し、血液検査で水痘帯状疱疹ウイルス(VZV)抗体価が上昇していたことからVZVの再活性化が関与した両側迷走神経麻痺と診断した。発症後約7ヵ月の時点で声帯の可動性の改善は軽度であり、咽喉頭の知覚、咳反射と嚥下反射の機能低下は残存している。

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Language：Japanese   Publisher：(一社)日本耳科学会  

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Language：Japanese   Publisher：耳鼻咽喉科臨床学会  

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Language：Japanese   Publisher：(一社)日本耳鼻咽喉科頭頸部外科学会  

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Language：Japanese   Publisher：(株)医学書院  

症例は67歳女性で、4ヵ月前に魚を食べた直後より咽頭に激痛を自覚した。2ヵ月経過した頃に右頸部痛を自覚し、その後右頸部の腫脹が出現した。精査・加療を目的に当科を紹介され受診した。頸部に迷人した魚骨異物の感染による右頸部蜂窩織炎および内頸静脈血栓症と診断し、パニペネム、ベタミプロン、クリンダマイシンの投与および抗凝固療法を開始した。治療開始6日目に頸部外切開による異物の摘出を試みたが異物の同定ができず、CTガイド下マーキングを行ったうえで前後方向の検索を行った。総頸動脈背側の線維化した組織内に長さ約1cm、棘状の魚骨を同定し摘出した。異物の摘出後、新たな合併症の出現はなく、頸部の発赤および胸鎖乳突筋の硬結は徐々に改善した。

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Language：Japanese   Publisher：姫路赤十字病院図書学術委員会  

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J02227&link_issn=&doc_id=20170727440003&doc_link_id=https%3A%2F%2Fredcross.repo.nii.ac.jp%2Frecords%2F12180&url=https%3A%2F%2Fredcross.repo.nii.ac.jp%2Frecords%2F12180&type=%E6%97%A5%E6%9C%AC%E8%B5%A4%E5%8D%81%E5%AD%97%E7%A4%BE%EF%BC%9A%E8%B5%A4%E5%8D%81%E5%AD%97%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80143_3.gif