研究者詳細 - 森永　裕士

論文 - 森永　裕士

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Autoimmune pancreatitis and minimal change nephrotic syndrome: an unusual association? 査読

Okuyama Y, Uchida HA, Tenta M, Nunoue T, Umebayashi R, Morinaga H, Kitamura S, Maeshima Y, Sugiyama H, Wada J

Nephrology (Carlton) 20 ( 3 ) 225 - 226 2015年3月

有吉勇一, 荒木元朗, 宗石理沙, 吉岡貴史, 和田耕一郎, 小林泰之, 佐々木克己, 江原伸, 渡辺豊彦, 那須保友, 公文裕巳, 有森千聖, 北川正史, 田邊克幸, 森永裕士, 菊本陽子, 内田治仁, 喜多村真治, 前島洋平, 杉山斉, 槇野博史

移植 49 ( 4-5 ) 377 - 377 2014年11月

A LOWER LEVEL OF SERUM BETA-2 MICROGLOBULIN SIGNIFICANTLY PREDICTS BETTER SURVIVAL IN ASSOCIATION WITH PRESERVED RESIDUAL RENAL FUNCTION IN PATIENTS ON PERITONEAL DIALYSIS - A PROSPECTIVE MULTICENTER COHORT STUDY (PDR-CS) 査読

Morinaga Hiroshi, Sugiyama Hitoshi, Ito Yasuhiko, Tsuruya Kazuhiko, Yoshida Hisako, Maruyama Hiroki, Goto Shin, Nishino Tomoya, Terawaki Hiroyuki, Nakayama Masaaki, Nakamoto Hidetomo, Matsuo Seiichi, Makino Hirofumi

NEPHROLOGY 19 70 - 70 2014年5月

岡山大学泌尿器科におけるpreemptive腎移植症例の検討

有吉勇一, 荒木元朗, 宗石理沙, 吉岡貴史, 和田耕一郎, 小林泰之, 佐々木克己, 江原伸, 渡辺豊彦, 那須保友, 公文裕巳, 清水千聖, 赤木滋, 森永裕士, 田邊克幸, 北川正史, 杉山斉, 和田淳, 槇野博史

移植 49 ( 1 ) 167 - 167 2014年5月

化学療法中に発生した血液透析を要する急性腎不全症例の検討

田邊克幸, 田中景子, 小松原基志, 大西章史, 寺見直人, 中山和典, 綿谷博雪, 益田加奈, 井上淳子, 山成俊夫, 森永裕士, 杉山斉, 槇野博史

日本透析医学会雑誌 47 ( Suppl.1 ) 1011 - 1011 2014年5月

Sarcoid-like lung granulomas in a hemodialysis patient treated with a dipeptidyl peptidase-4 inhibitor. 査読

Sada KE, Wada J, Morinaga H, Tuchimochi S, Uka M, Makino H

Clin Kidney J 7 ( 2 ) 182 - 185 2014年4月

Sarcoid-like lung granulomas in a hemodialysis patient treated with a dipeptidyl peptidase-4 inhibitor 査読

Ken-Ei Sada, Jun Wada, Hiroshi Morinaga, Shigeyuki Tuchimochi, Mayu Uka, Hirofumi Makino

Clinical Kidney Journal 7 ( 2 ) 182 - 185 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press

It has been reported that the inhibition of dipeptidyl peptidase-4 (DPP-4)/CD26 on T-cells by DPP-4 enzymatic inhibitors suppresses lymphocyte proliferation and reduces the production of various cytokines, including tumor necrosis factor (TNF)-α. A 72-year-old female with diabetic nephropathy on hemodialysis developed multiple lung nodules following the administration of vildagliptin. A biopsy demonstrated the histology of granulomas without caseous necrosis. The discontinuation of vildagliptin resulted in the disappearance of the granulomas within 4 months. As granulomatosis often develops in patients under anti-TNF-α therapy, the accumulation of DPP-4 inhibitors or its metabolites is possibly linked to unrecognized complications, such as sarcoid-like lung granulomas. © 2014 © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

DOI： 10.1093/ckj/sft172

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その他リンク： http://orcid.org/0000-0003-1468-5170

急性腎不全で発症し透析を離脱し得たSLEの1例

大西章史, 森永裕士, 赤木滋, 北川正史, 井上章子, 寺見直人, 山成俊夫, 辻憲二, 氏家はる代, 小川愛由, 中山和典, 綿谷博雪, 井上淳子, 田邊克幸, 杉山斉, 槇野博史

日本腎臓学会誌 55 ( 6 ) 1211 - 1211 2013年8月

A Decreased Level of Serum Soluble Klotho Is an Independent Biomarker Associated with Arterial Stiffness in Patients with Chronic Kidney Disease 査読

Kitagawa Masashi, Sugiyama Hitoshi, Morinaga Hiroshi, Inoue Tatsuyuki, Takiue Keiichi, Ogawa Ayu, Yamanari Toshio, Kikumoto Yoko, Uchida Haruhito Adam, Kitamura Shinji, Maeshima Yohei, Nakamura Kazufumi, Ito Hiroshi, Makino Hirofumi

PLoS ONE 8 ( 2 ) e56695 - e56695 2013年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Public Library Science

Background: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community-dwelling adults. However, it is unclear whether the serum Klotho levels are associated with signs of vascular dysfunction such as arterial stiffness, a major determinant of prognosis, in human subjects with chronic kidney disease (CKD). Methods: We determined the levels of serum soluble Klotho in 114 patients with CKD using ELISA and investigated the relationship between the level of Klotho and markers of CKD-mineral and bone disorder (CKD-MBD) and various types of vascular dysfunction, including flow-mediated dilatation, a marker of endothelial dysfunction, ankle-brachial pulse wave velocity (baPWV), a marker of arterial stiffness, intima-media thickness (IMT), a marker of atherosclerosis, and the aortic calcification index (ACI), a marker of vascular calcification. Results: The serum Klotho level significantly correlated with the 1,25-dihydroxyvitamin D level and inversely correlated with the parathyroid hormone level and the fractional excretion of phosphate. There were significant decreases in serum Klotho in patients with arterial stiffness defined as baPWV >= 1400 cm/sec, atherosclerosis defined as maximum IMT >= 1.1 mm and vascular calcification scores of ACI>0%. The serum Klotho level was a significant determinant of arterial stiffness, but not endothelial dysfunction, atherosclerosis or vascular calcification, in the multivariate analysis in either metabolic model, the CKD model or the CKD-MBD model. The adjusted odds ratio of serum Klotho for the baPWV was 0.60 (p = 0.0075). Conclusions: Decreases in the serum soluble Klotho levels are independently associated with signs of vascular dysfunction such as arterial stiffness in patients with CKD. Further research exploring whether therapeutic approaches to maintain or elevate the Klotho level could improve arterial stiffness in CKD patients is warranted.

DOI： 10.1371/journal.pone.0056695

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HD併用療法の実態調査〜アンケート集計結果とPDR-CSレジストリから〜

森永裕士, 杉山斉, 山成俊夫, 小川愛由, 北川正史, 瀧上慶一, 菊本陽子, 内田治仁, 喜多村真治, 赤木滋, 前島洋平, 槇野博史

腎と透析別冊腹膜透析2013 75 161 - 162 2013年

【腎疾患治療薬マニュアル2013-14】透析患者に対する薬の使い方疾患別・病態別[感染症] MRSA感染症

森永裕士, 杉山斉

腎と透析 74 ( 増刊 ) 579 - 583 2013年

REVERSIBLE POSTERIOR LEUKOENCEPHALOPATHY SYNDROME IN A YOUNG ADULT PATIENT RECEIVING PERITONEAL DIALYSIS 査読

Ayu Ogawa, Hitoshi Sugiyama, Kazunori Nakayama, Hiroshi Morinaga, Shigeru Akagi, Hirofumi Makino

PERITONEAL DIALYSIS INTERNATIONAL 32 ( 6 ) 587 - 589 2012年11月

The frequency of Fabry disease with the E66Q variant in the ?-galactosidase A gene in Japanese dialysis patients: a case report and a literature review 査読

Y. Kikumoto, H. Sugiyama, H. Morinaga, T. Inoue, K. Takiue, M. Kitagawa, D. Saito, Y. Takatori, M. Kinomura, S. Kitamura, S. Akagi, K. Sada, K. Nakao, Y. Maeshima, H. Kitayama, H. Makino

Clinical Nephrology 78 ( 09 ) 224 - 229 2012年9月

Effluent Free Radicals Are Associated with Residual Renal Function and Predict Technique Failure in Peritoneal Dialysis Patients 査読

Hiroshi Morinaga, Hitoshi Sugiyama, Tatsuyuki Inoue, Keiichi Takiue, Yoko Kikumoto, Masashi Kitagawa, Shigeru Akagi, Kazushi Nakao, Yohei Maeshima, Ikuko Miyazaki, Masato Asanuma, Makoto Hiramatsu, Hirofumi Makino

Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 32 ( 4 ) 453 - 461 2012年7月

担当区分：筆頭著者記述言語：英語掲載種別：学位論文（博士）出版者・発行元：SAGE Publications

<sec><title>Objective</title> Residual renal function (RRF) is associated with low oxidative stress in peritoneal dialysis (PD). In the present study, we investigated the relationship between the impact of oxidative stress on RRF and patient outcomes during PD.

</sec><sec><title>Methods</title> Levels of free radicals (FRs) in effluent from the overnight dwell in 45 outpatients were determined by electron spin resonance spectrometry. The FR levels, clinical parameters, and the level of 8-hydroxy-2′-deoxyguanosine were evaluated at study start. The effects of effluent FR level on technique and patient survival were analyzed in a prospective cohort followed for 24 months.

</sec><sec><title>Results</title> Levels of effluent FRs showed significant negative correlations with daily urine volume and residual renal Kt/V, and positive correlations with plasma β₂-microglobulin and effluent 8-hydroxy-2′-deoxyguanosine. A highly significant difference in technique survival ( p < 0.05), but not patient survival, was observed for patients grouped by effluent FR quartile. The effluent FR level was independently associated with technique failure after adjusting for patient age, history of cardiovascular disease, and presence of diabetes mellitus ( p < 0.001). The level of effluent FRs was associated with death-censored technique failure in both univariate ( p < 0.001) and multivariate ( p < 0.01) hazard models. Compared with patients remaining on PD, those withdrawn from the modality had significantly higher levels of effluent FRs ( p < 0.005).

</sec><sec><title>Conclusions</title> Elevated effluent FRs are associated with RRF and technique failure in stable PD patients. These findings highlight the importance of oxidative stress as an unfavorable prognostic factor in PD and emphasize that steps should be taken to minimize oxidative stress in these patients.

</sec>

DOI： 10.3747/pdi.2011.00032

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その他リンク： http://journals.sagepub.com/doi/full-xml/10.3747/pdi.2011.00032

Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis 査読

Keiichi Takiue, Hitoshi Sugiyama, Tatsuyuki Inoue, Hiroshi Morinaga, Yoko Kikumoto, Masashi Kitagawa, Shinji Kitamura, Yohei Maeshima, Da-Hong Wang, Noriyoshi Masuoka, Keiki Ogino, Hirofumi Makino

BMC NEPHROLOGY 13 14 2012年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BIOMED CENTRAL LTD

Background: Catalase is an important antioxidant enzyme that regulates the level of intracellular hydrogen peroxide and hydroxyl radicals. The effects of catalase deficiency on albuminuria and progressive glomerulosclerosis have not yet been fully elucidated. The adriamycin (ADR) nephropathy model is considered to be an experimental model of focal segmental glomerulosclerosis. A functional catalase deficiency was hypothesized to exacerbate albuminuria and the progression of glomerulosclerosis in this model.
Methods: ADR was intravenously administered to both homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) and control wild-type mice (C3H/AnLCs(a)Cs(a)). The functional and morphological alterations of the kidneys, including albuminuria, renal function, podocytic, glomerular and tubulointerstitial injuries, and the activities of catalase were then compared between the two groups up to 8 weeks after disease induction. Moreover, the presence of a mutation of the toll-like receptor 4 (tlr4) gene, which was previously reported in the C3H/HeJ strain, was investigated in both groups.
Results: The ADR-treated mice developed significant albuminuria and glomerulosclerosis, and the degree of these conditions in the ADR-treated acatalasemic mice was higher than that in the wild-type mice. ADR induced progressive renal fibrosis, renal atrophy and lipid peroxide accumulation only in the acatalasemic mice. In addition, the level of catalase activity was significantly lower in the kidneys of the acatalasemic mice than in the wild-type mice during the experimental period. The catalase activity increased after ADR injection in wild-type mice, but the acatalasemic mice did not have the ability to increase their catalase activity under oxidative stress. The C3H/AnL strain was found to be negative for the tlr4 gene mutation.
Conclusions: These data indicate that catalase deficiency plays an important role in the progression of renal injury in the ADR nephropathy model.

DOI： 10.1186/1471-2369-13-14

Web of Science

PubMed

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Suppression of Adiponectin by Aberrantly Glycosylated IgA1 in Glomerular Mesangial Cells In Vitro and In Vivo 査読

Tatsuyuki Inoue, Hitoshi Sugiyama, Masashi Kitagawa, Keiichi Takiue, Hiroshi Morinaga, Ayu Ogawa, Yoko Kikumoto, Shinji Kitamura, Yohei Maeshima, Hirofumi Makino

PLOS ONE 7 ( 3 ) e33965 2012年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PUBLIC LIBRARY SCIENCE

The pathogenesis of IgA nephropathy (IgAN) may be associated with the mesangial deposition of aberrantly glycosylated IgA1. To identify mediators affected by aberrantly glycosylated IgA1 in cultured human mesangial cells (HMCs), we generated enzymatically modified desialylated and degalactosylated (deSial/deGal) IgA1. The state of deglycosylated IgA1 was confirmed by lectin binding to Helix aspersa (HAA) and Sambucus nigra (SNA). In the cytokine array analysis, 52 proteins were upregulated and 34 were downregulated in HMCs after stimulation with deSial/deGal IgA1. Among them, the secretion of adiponectin was suppressed in HMCs after stimulation with deSial/deGal IgA1. HMCs expressed mRNAs for adiponectin and its type 1 receptor, but not the type 2 receptor. Moreover, we revealed a downregulation of adiponectin expression in the glomeruli of renal biopsy specimens from patients with IgAN compared to those with lupus nephritis. We also demonstrated that aberrantly glycosylated IgA1 was deposited in the mesangium of patients with IgAN by dual staining of HAA and IgA. Moreover, the urinary HAA/SNA ratio of lectin binding was significantly higher in IgAN compared to other kidney diseases. Since adiponectin has anti-inflammatory effects, including the inhibition of adhesion molecules and cytokines, these data suggest that the local suppression of this adipokine by aberrantly glycosylated IgA1 could be involved in the regulation of glomerular inflammation and sclerosis in IgAN.

DOI： 10.1371/journal.pone.0033965

Web of Science

PubMed

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日本発PD療法のエビデンスを目指して多施設PD合同レジストリー前向きコホート研究によるエビデンス創出を目指して

杉山斉, 伊藤恭彦, 鶴屋和彦, 吉田寿子, 丸山弘樹, 後藤眞, 中山昌明, 森永裕士, 槇野博史, 松尾清一

腎と透析別冊腹膜透析2012 73 22 - 24 2012年

【腎臓症候群(第2版)下-その他の腎臓疾患を含めて-】維持透析患者にみられる病態栄養障害(MIA症候群)

森永裕士, 杉山斉

日本臨床腎臓症候群下 188 - 192 2012年

Icodextrin Increases Technique Survival Rate in Peritoneal Dialysis Patients with Diabetic Nephropathy by Improving Body Fluid Management: A Randomized Controlled Trial 査読

Yuji Takatori, Shigeru Akagi, Hitoshi Sugiyama, Junko Inoue, Shoichiro Kojo, Hiroshi Morinaga, Kazushi Nakao, Jun Wada, Hirofumi Makino

Clinical Journal of the American Society of Nephrology 6 ( 6 ) 1337 - 1344 2011年6月

Serum high-sensitivity cardiac troponin T is a significant biomarker of left-ventricular diastolic dysfunction in subjects with non-diabetic chronic kidney disease. 査読国際誌

Kitagawa M, Sugiyama H, Morinaga H, Inoue T, Takiue K, Kikumoto Y, Uchida HA, Kitamura S, Maeshima Y, Toh N, Nakamura K, Ito H, Makino H

Nephron extra 1 ( 1 ) 166 - 177 2011年1月

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