Faculty Profiles - MORIMATSU Hiroshi

MISC - MORIMATSU Hiroshi

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小児心臓手術術後の血清Brain Natriuretic Peptide(BNP)に対する治療介入の現状

黒江泰利, 金澤伴幸, 塩路直弘, 野々村智子, 杉本健太郎, 末盛智彦, 清水一好, 岩崎達雄, 森松博史

Cardiovascular Anesthesia 20 ( Suppl ) 2016

Intracranial hemorrhage and pneumozephalus after spinal cord tumor resection a case report

Keisuke Goda, Daniel Obata, Tomoyuki Kanazawa, Akiko Miyoshi, Toshihiro Sasaki, Tomohiko Suemori, Kazuyoshi Shimizu, Hiroshi Morimatsu

Japanese Journal of Anesthesiology 65 ( 12 ) 1271 - 1275 2016

Kidney, Fluid, and Acid-Base Balance

65 ( 5 ) 503 - 510 2016

Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation.

Wake H, Mori S, Liu K, Morioka Y, Teshigawara K, Sakaguchi M, Kuroda K, Gao Y, Takahashi H, Ohtsuka A, Yoshino T, Morimatsu H, Nishibori M

EBioMedicine 9 180 - 194 2016

コントロール不良の肺動脈性肺高血圧症に合併した急性肺動脈解離の一例

川出健嗣, 清水一好, 林真雄, 谷真規子, 鈴木聡, 金澤伴幸, 岩崎達雄, 森松博史

日本集中治療医学会雑誌(Web) 23 ( 3 ) 2016

HISTIDINE-RICH GLYCOPROTEIN AS A NEW BIOMARKER FOR SEPSIS: COMPARISON TO PROCALCITONIN AND PRESEPSIN

Kosuke Kuroda, Hiroshi Morimatsu, Hidenori Wake, Shiji Mori, Masahiro Nishibori

CRITICAL CARE MEDICINE 43 ( 12 ) 2015.12

岡山大学病院ICUにおける急性肝不全に対する肝移植までのBridging Therapyについて

賀来隆治, 楳田祐三, 松崎孝, 柴田麻里, 篠浦先, 吉田龍一, 信岡大輔, 保田裕子, 高木章乃夫, 八木孝仁, 森松博史

移植 50 ( 4-5 ) 477 - 478 2015.10

術後低換気高リスク患者における回復室でCapnostream 20を用いた呼吸状態の評価

黒江泰利, 岡原修司, 石井賢造, 金澤伴幸, 森松博史

日本臨床麻酔学会誌 35 ( 6 ) S257 - S257 2015.10

慢性疼痛患者に対するオピオイド使用経験長期投与の検討

妹尾悠祐, 松崎孝, 谷口新, 賀来隆治, 森松博史

日本臨床麻酔学会誌 35 ( 6 ) S310 - S310 2015.10

Goal-Directed Therapy(目標指向型輸液療法)の実践国内外の実例を交えて ERAS時代のGDT

松崎孝, 賀来隆治, 森松博史

日本臨床麻酔学会誌 35 ( 6 ) S166 - S166 2015.10

Cerebral Blood Flow Threshold Is Higher for Membrane Repolarization Than for Depolarization and Is Lowered by Intraischemic Hypothermia in Rats

Ryoichi Mizoue, Yoshimasa Takeda, Sachiko Sato, Ken Takata, Hiroshi Morimatsu

CRITICAL CARE MEDICINE 43 ( 9 ) E350 - E355 2015.9

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

Objectives: To evaluate the cerebral blood flow thresholds for membrane depolarization and repolarization and the effect of brain hypothermia on the cerebral blood flow threshold for membrane repolarization.
Design: Prospective animal study.
Setting: Experimental laboratory in a university hospital.
Subjects: Male Sprague-Dawley rats (n = 40).
Interventions: Cerebral blood flow and membrane depolarization and repolarization in the cerebral cortex were simultaneously monitored by laser Doppler and extracellular potential, respectively. Following bilateral occlusion of the common carotid arteries, cerebral blood flow was decreased by draining blood at a rate of 2.5% of the control level/min until membrane depolarization was initiated. At 5 and 10 minutes (Normothermia 5 and Normothermia 10 groups, respectively) after depolarization onset, cerebral blood flow was restored at the same rate until membrane repolarization was observed. In some animals, intraischemic brain hypothermia targeting 31 degrees C was initiated immediately after the onset of depolarization (Hypothermia 5 and Hypothermia 10 groups).
Measurements and Main Results: The cerebral blood flow threshold for repolarization (46.5% +/- 12%) was significantly higher than that for depolarization (18.9% +/- 4.8%; p < 0.01) in the Normothermia 5 group and was further increased to 61.5% +/- 14% (p < 0.01) in the Normothermia 10 group. With initiation of hypothermia, the cerebral blood flow threshold for membrane repolarization was suppressed to 33.8% +/- 10% in the Hypothermia 5 group (p < 0.01 vs Normothermia 5 group) and was unaltered by prolongation of ischemia (Hypothermia 10 group; 36.6% +/- 6%).
Conclusions: Cerebral blood flow thresholds were significantly higher for repolarization than for depolarization and were further increased by prolonged ischemia. Intraischemic brain hypothermia decreased the repolarization threshold and abrogated the increase in the repolarization threshold caused by prolonged ischemia.

DOI： 10.1097/CCM.0000000000001095

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小児肝芽腫に対する生体肝移植術中の下大静脈-内頸静脈バイパス使用経験

熊田雄太, 松崎孝, 柴田麻理, 賀来隆治, 宮本綾子, 吉田龍一, 保田裕子, 森松博史

日本小児麻酔学会誌 21 ( 1 ) 133 - 133 2015.8

当院における新たな脊髄硬膜外刺激電極療法の取り組み

松崎孝, 賀来隆治, 吉岡清行, 西江宏行, 佐藤健治, 藤井洋泉, 高須賀功喜, 古川達也, 森松博史

日本ペインクリニック学会誌 22 ( 3 ) 393 - 393 2015.6

Intraoperative change of lactate level is associated with postoperative outcomes in pediatric cardiac surgery patients: retrospective observational study

Tomoyuki Kanazawa, Moritoki Egi, Kazuyoshi Shimizu, Yuichiro Toda, Tatsuo Iwasaki, Hiroshi Morimatsu

BMC ANESTHESIOLOGY 15 29 2015.3

Language：English Publisher：BIOMED CENTRAL LTD

Background: A change of serum lactate concentrations appeared to be useful for predicting outcomes in various acute ill settings. However, there is little information on intraoperative change of lactate level in pediatric cardiac surgery patients.
Methods: We conducted a retrospective observational study of 459 children who received pediatric cardiac surgery to determine the association between change of lactate level after cardiopulmonary bypass (CPB) and patient prognosis (length of ICU stay and incidence of postoperative serious adverse events (SAEs)). We defined change of lactate level after CPB (LAC.) as (final lactate level measurement in the operating room) - (lactate level measured at the end of CPB). To study the independent association of LAC. with length of ICU stay, we used linear regression model.
Results: There were 1145 lactate measurements after CPB in this study cohort. After weaning from CPB, the serum lactate levels significantly increased from 2.1 mmol/L to 2.5 mmol/L (p < 0.001). Patients with higher LAC. had significantly longer stay in ICU (p = 0.017) and higher incidence of SAEs (p = 0.002). In multivariate linear regression analysis, higher LAC. showed a significant independent association with longer length of ICU stay.
Conclusions: Increased lactate level after CPB was associated with the longer duration of ICU stay and increased risk of postoperative SAEs in pediatric cardiac surgery patients. Future studies should be conducted to determine the clinical utility of intraoperative trend of lactate levels.

DOI： 10.1186/s12871-015-0007-y

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肝移植術中の酸素消費量の測定意義

柴田麻理, 松崎孝, 賀来隆治, 藤井洋泉, 森松博史

日本集中治療医学会雑誌 22 ( Suppl. ) [DP62 - 3] 2015.1

ERASと周術期チーム医療

白川靖博, 加藤卓也, 竹原清人, 前田直見, 田辺俊介, 櫻間教文, 野間和広, 足羽孝子, 佐藤健治, 森松博史, 藤原俊義

臨床雑誌外科 77 ( 2 ) 142 - 146 2015

Renal replacement therapy for AKI

57 ( 2 ) 308 - 312 2015

Perioperative managements for pediatric lung transplantation

日笠友起子, 岡原修司, 清水一好, 小林求, 森松博史

移植(Web) 50 ( 6 ) 2015

Management of Lacerated and Swollen Tongue after Convulsive Seizure with a Mouth Protector: Interprofessional Collaboration Including Dentists in Intensive Care

Reiko Yamanaka, Yoshihiko Soga, Yoshie Moriya, Akemi Okui, Tetsuo Takeuchi, Kenji Sato, Hiroshi Morimatsu, Manabu Morita

ACTA MEDICA OKAYAMA 68 ( 6 ) 375 - 378 2014.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

We encountered a 74-year-old male patient with tongue laceration after convulsive seizures under intensive care. The tongue showed severe swelling, and the right ventral surface had been lacerated by his isolated and pointed right lower canine. Our university hospital has established a perioperative management center, and is promoting interprofessional collaboration, including dentists, in perioperative management. Dentists collaborating in the perioperative management center took dental impressions, with the support of anesthesiologists who opened the patient's jaw under propofol sedation, to produce a mouth protector. By raising the patient's bite, the completed mouth protector prevented the isolated tooth from contacting the tongue and protected the lacerated wound. Use of the mouth protector prevented the lacerated tongue from coming into contact with the pointed tooth, and the tongue healed gradually. These findings underscore that interprofessional collaboration including dentists can improve the quality of medical care.

DOI： 10.18926/AMO/53027

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The association of plasma gamma-aminobutyric acid concentration with postoperative delirium in critically ill patients

Shiho Yoshitaka, Moritoki Egi, Tomoyuki Kanazawa, Yuichiro Toda, Kiyoshi Morita

CRITICAL CARE AND RESUSCITATION 16 ( 4 ) 269 - 273 2014.12

Language：English Publisher：AUSTRALASIAN MED PUBL CO LTD

Objective: Delirium is a common complication in postoperative, critically ill patients. The mechanism of postoperative delirium is not well understood but many studies have shown significant associations between benzodiazepine use, alcohol withdrawal and cirrhosis, and an increased risk of delirium. We aimed to investigate a possible link with alterations of gamma-aminobutyric acid (GABA) activity.
Design, setting and participants: A prospective observational investigation of 40 patients >20 years old who had undergone elective surgery with general anaesthesia and were expected to need postoperative intensive care for more than 48 hours. We assessed postoperative delirium using the confusion assessment method in the intensive care unit at 1 hour after the operation and on postoperative Day (POD) 1 and POD 2. We collected blood samples for measurement of plasma GABA concentrations before the operation and on POD 1 and 2.
Main outcome measures: Postoperative delirium and perioperative plasma GABA concentrations in patients with and without delirium. Results: Postoperative delirium occurred in 13 of the patients. Patients with delirium had significantly higher Acute Physiology and Chronic Health Evaluation IF scores than patients without delirium. The mean plasma GABA concentration on POD 2 was significantly lower in patients with delirium than in those without delirium. After adjustment of relevant variables, plasma GABA concentration on POD 2 was independently associated with postoperative delirium.
Conclusions: Plasma GABA level on POD 2 has a significant independent association with postoperative delirium.

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