Updated on 2025/05/05

写真a

 
MORIMATSU Hiroshi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
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Degree

  • Medical doctor ( 2007.3   Okayama University )

Research Interests

  • Intensive Care

  • 麻酔

  • 集中治療

  • Anesthesiology

Research Areas

  • Life Science / Anesthesiology

Education

  • Okayama University Graduate School   Division of Medicine  

    - 2007.3

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    Country: Japan

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  • Okayama University   医学部   医学科

    1987.4 - 1993.3

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    Country: Japan

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Research History

  • Academic Field of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University   Anesthesiology and Resuscitology   Professor

    2021.4

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    Country:Japan

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  • Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University   Anesthesiology and Resuscitology   Professor

    2013.4 - 2021.3

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    Country:Japan

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  • Okayama University Hospital   周術期管理センター   Lecturer

    2010.11 - 2013.3

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    Country:Japan

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  • Okayama University Hospital   麻酔部   Senior Assistant Professor

    2010.5 - 2010.10

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    Country:Japan

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  • 岡山大学医学部・歯学部附属病院   助教

    2007.5 - 2010.4

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    Country:Japan

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Papers

  • Clinical predictors of extubation failure in postoperative critically ill patients: a post-hoc analysis of a multicenter prospective observational study. International journal

    Jun Hattori, Aiko Tanaka, Junko Kosaka, Osamu Hirao, Nana Furushima, Yuichi Maki, Daijiro Kabata, Akinori Uchiyama, Moritoki Egi, Hiroshi Morimatsu, Satoshi Mizobuchi, Yoshifumi Kotake, Ayumi Shintani, Yukiko Koyama, Takeshi Yoshida, Yuji Fujino

    BMC anesthesiology   25 ( 1 )   127 - 127   2025.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: Postoperative patients constitute majority of critically ill patients, although factors predicting extubation failure in this group of patients remain unidentified. Aiming to propose clinical predictors of reintubation in postoperative patients, we conducted a post-hoc analysis of a multicenter prospective observational study. METHODS: This study included postoperative critically ill patients who underwent mechanical ventilation for > 24 h and were extubated after a successful 30-min spontaneous breathing trial. The primary outcome was reintubation within 48 h after extubation, and clinical predictors for reintubation were investigated using logistic regression analyses. RESULTS: Among the 355 included patients, 10.7% required reintubation. Multivariable logistic regression identified that the number of endotracheal suctioning episodes during the 24 h before extubation and underlying respiratory disease or pneumonia occurrence were significantly associated with reintubation (adjusted odds ratio [OR] 1.11, 95% confidence interval [CI] 1.05-1.18, p < 0.001; adjusted OR 2.58, 95%CI 1.30-5.13, p = 0.007). The probability of reintubation was increased significantly with the higher frequency of endotracheal suctioning, as indicated by restricted cubic splines. Subgroup analysis showed that these predictors were consistently associated with reintubation regardless of the use of noninvasive respiratory support after extubation. CONCLUSIONS: Endotracheal suctioning frequency and respiratory complications were identified as independent predictors of reintubation. These readily obtainable predictors may aid in decision-making regarding the extubation of postoperative patients.

    DOI: 10.1186/s12871-025-02996-1

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  • Preoperative Nutritional Status Influences Enteral Nutrition Weaning 6 Months Post-Surgery in Patients with Esophageal Cancer. International journal

    Mika Sonoi, Yasuhiro Shirakawa, Norihiro Sonoi, Kazuhiro Noma, Shunsuke Tanabe, Naoaki Maeda, Hiroshi Morimatsu

    Asian Pacific journal of cancer prevention : APJCP   26 ( 1 )   263 - 267   2025.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: This study aimed to clarify whether nutritional status at admission affects enteral nutrition weaning 6 months after surgery in patients with esophageal cancer. METHODS: This was a retrospective study of 81 patients who underwent subtotal esophageal cancer resection between April 2014 and February 2016. The survey items were as follows: 1) sex, 2) age, 3) presence or absence of family members living together, 4) clinical stage, 5) surgical procedure, 6) reconstructed organs, 7) nutritional status at admission, 8) presence or absence of postoperative complications (anastomotic leakage, chylothorax, and recurrent laryngeal nerve paralysis), and 9) presence or absence of treatment other than surgery (chemo- or radiotherapy). RESULTS: The enteral nutrition withdrawal rate after 6 months was 15.5% in the malnutrition group and 84.5% in the normal nutrition group (p = 0.007). In a comparison between groups with and without enteral nutrition after 6 months, a significant association was observed with surgical procedure, nutritional status at admission, and postoperative complications (p < 0.05). Logistic regression analysis showed that the odds of discontinuing enteral nutrition 6 months later were 5.692 (hazard ratio: 1.545-20.962) for malnutrition on admission and 11.921 (hazard ratio: 3.449-41.207) for complications. CONCLUSION: Regardless of the presence or absence of treatment other than surgery, preoperative nutritional improvement is beneficial for increasing postoperative oral intake.

    DOI: 10.31557/APJCP.2025.26.1.263

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  • Association between plasma-free haemoglobin and postoperative acute kidney injury in paediatric cardiac surgery: a prospective observational study Reviewed

    Takanobu Sakura, Tomoyuki Kanazawa, Tatsuhiko Shimizu, Kazuyoshi Shimizu, Tatsuo Iwasaki, Hiroshi Morimatsu

    BJA Open   12   100348 - 100348   2024.12

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.bjao.2024.100348

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  • Subjective global assessment for nutritional screening and its impact on surgical outcomes: A prospective study in older patients with colorectal cancer. International journal

    Fuminori Teraishi, Yusuke Yoshida, Ryohei Shoji, Nobuhiko Kanaya, Yuki Matsumi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Shunsuke Kagawa, Rie Tamura, Yoshikazu Matsuoka, Hiroshi Morimatsu, Toshiharu Mitsuhashi, Toshiyoshi Fujiwara

    Langenbeck's archives of surgery   409 ( 1 )   356 - 356   2024.11

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    PURPOSE: Our perioperative management center provides preoperative intervention and functional and nutritional assessments for colorectal cancer patients aged over 75 years. This study evaluated the associations of preoperative nutritional status with postoperative outcomes and prognosis in colorectal cancer patients aged 75 years or older. METHODS: This was a prospective, observational study of 71 colorectal cancer patients aged 75 years or older who underwent surgery between July 2020 and September 2022. The Subjective Global Assessment (SGA) was evaluated as a nutritional index. The patients were classified into three groups: SGA-A (well nourished), B (moderately malnourished), and C (severely malnourished), and the correlations with postoperative outcomes and prognosis were examined. RESULTS: The median age of the 71 patients (34 males, 37 females) was 78 (75-92) years, and their median body mass index (BMI) was 22.3 (13.4-31.9) kg/m2. Forty-eight patients had colon cancer, and 23 had rectal cancer. On the SGA, 28 patients were SGA-A, 25 SGA-B, and 18 SGA-C. The SGA-B/C group had significantly higher BMI (p < 0.01) and more ICU admissions (p = 0.02). The G8 score was significantly lower (p = 0.03) in the SGA-B/C group, suggesting coexisting functional decline. In terms of postoperative outcomes, the SGA-B/C group had a significantly longer postoperative hospital stay (p = 0.04). The 3-year OS rates for all stages were 100% in the SGA-A group and 49.7% in the SGA-B/C group (p = 0.03), while the 3-year OS rates for patients excluding Stage IV were 100% in the SGA-A group and 68.5% in the SGA-B/C group, not significantly different (p = 0.14). The 3-year RFS rate was 95.5% in the SGA-A group and 65.3% in the SGA-B/C group (p = 0.15). CONCLUSION: The SGA is a promising nutritional index associated with short-term outcomes in older patients undergoing colorectal cancer surgery. The SGA can be assessed in a few minutes during an outpatient visit, making it useful for routine clinical use.

    DOI: 10.1007/s00423-024-03548-w

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  • Oxygen Delivery During Cardiopulmonary Bypass in Pediatric Patients With Congenital Heart Disease: Association With Postoperative Acute Kidney Injury. International journal

    Hiroshi Taka, Takuma Douguchi, Ayako Miyamoto, Kazuyoshi Shimizu, Tatsuo Iwasaki, Tomoyuki Kanazawa, Satoshi Kimura, Hiroshi Morimatsu

    Journal of cardiothoracic and vascular anesthesia   2024.11

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    OBJECTIVE: This study was designed to investigate the distribution of nadir oxygen delivery (DO2), mean DO2, and area under ideal DO2 (AUiDO2) among categorized age groups of pediatric patients and their associations with postoperative cardiac surgery-associated (CSA) acute kidney injury (AKI) and clinical outcomes. DESIGN: Retrospective cohort study. SETTING: A tertiary teaching hospital. PARTICIPANTS: Patients aged <15 years with congenital heart disease who underwent cardiac surgery between May 2018 and May 2022. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Nadir DO2, mean DO2, and AUiDO2 were defined as the lowest DO2, average DO2, and dose of decrement combining the intensity and duration of DO2 less than the calculated ideal DO2, respectively. The primary outcome was CSA-AKI occurrence within 48 hours postoperatively. Secondary outcomes included maximum serum lactate levels (Lacmax) for the first 24 hours after pediatric cardiac intensive care unit admission. Of 479 patients, 147 (30.7%) developed AKI. Nadir DO2 and AUiDO2 were not significantly different between patients with CSA-AKI and those without CSA-AKI (p = 0.115 and p = 0.12, respectively). However, the mean DO2 was significantly higher in patients with CSA-AKI (p = 0.025). After adjusting for potential confounders, no significant differences were observed in the odds for CSA-AKI based on increments in nadir DO2, mean DO2, or AUiDO2. In contrast, nadir DO2 and mean DO2 were significantly associated with Lacmax in both univariate and multivariable regression analyses. CONCLUSION: DO2-related values during cardiopulmonary bypass were not associated with CSA-AKI in pediatric patients with congenital heart disease. However, nadir DO2 and mean DO2 were significantly associated with postoperative serum lactate levels.

    DOI: 10.1053/j.jvca.2024.11.017

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Books

  • 急性循環不全

    藤野, 裕士, 松田, 直之, 森松, 博史

    中山書店  2019.5  ( ISBN:9784521743356

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    Total pages:x, 342p   Language:Japanese

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  • 重症患者における急性肝不全・急性腎傷害・代謝異常

    森松, 博史, 藤野, 裕士, 松田, 直之

    中山書店  2018.3  ( ISBN:9784521743349

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    Total pages:ix, 298p   Language:Japanese

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  • 重症患者における炎症と凝固・線溶系反応

    松田, 直之, 藤野, 裕士, 森松, 博史

    中山書店  2017.3  ( ISBN:9784521743332

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    Total pages:ix, 323p   Language:Japanese

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  • 急性呼吸不全

    藤野, 裕士, 松田, 直之, 森松, 博史

    中山書店  2016.4  ( ISBN:9784521743325

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    Total pages:ix, 323p   Language:Japanese

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  • 救急・集中治療アドバンス

    藤野, 裕士, 松田, 直之, 森松, 博史

    中山書店  2016 

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MISC

  • Preoperative assessment of patients with respiratory complications

    松岡義和, 清水達彦, 森松博史

    日本麻酔科学会学術集会(Web)   71st   2024

  • 妊産婦の心肺蘇生—最善で最新の産科麻酔診療をめざして ; 妊産婦急変対応

    木村 貴一, 金澤 伴幸, 森松 博史

    臨床婦人科産科   77 ( 1 )   193 - 199   2023

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    Language:Japanese   Publisher:医学書院  

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  • 顧客満足度分析を用いた岡山大学病院集中治療室における病棟薬剤師業務の評価

    大川恭昌, 宮本朋佳, 村尾卓哉, 勝部理早, 森田幸子, 妹尾育美, 村川公央, 清水一好, 森松博史, 座間味義人

    日本集中治療医学会中国・四国支部学術集会プログラム・抄録集(Web)   7th   2023

  • 難治性の腸管蠕動痛に対してオピオイド鎮痛薬が有効であった3例

    片山圭, 荒川恭佑, 森松博史

    日本ペインクリニック学会誌(Web)   30 ( program )   2023

  • 慢性疼痛発症に関与する炎症・侵害受容増幅因子HMGB1の血中動態解析に基づく客観的評価法の確立 慢性疼痛患者の診療・治療と臨床研究

    森松博史, 松岡義和, 荒川恭佑, 妹尾悠祐

    慢性疼痛発症に関与する炎症・侵害受容増幅因子HMGB1の血中動態解析に基づく客観的評価法の確立 令和4年度 総括・分担研究報告書(Web)   2023

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Presentations

  • rt-PA投与後、解離性大動脈瘤に対して人工血管置換を施行した症例.

    日本麻酔科学会中国・四国支部第51回学術集会  2014 

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  • Extubation in the Operating Room for an Orthotopic Hepato-Kidney Transplant Recipient.

    ASA, Anesthesiology 2014  2014 

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  • Mechanism of Increased Intraoperative Oxygen Consumption during Liver Transplantation.

    ASA, Anesthesiology 2014  2014 

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  • 藤田昌雄賞候補セッション 小児心臓手術における周術期BNPと術後Serious Adverse Events(SAEs)の関係

    日本心臓血管麻酔学会第19回学術大会  2014 

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  • 成人先天性心疾患の周術期管理

    日本心臓血管麻酔学会第19回学術大会  2014 

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Works

  • Novel biomarker for sepsis: HRG

    2015

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  • 敗血症における新しいバイオマーカー

    2015

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Research Projects

  • Development of drug therapy targeting ferroptosis, iron-dependent cell death for acute respiratory distress syndrome.

    Grant number:23K08360  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    清水 裕子, 森松 博史, 中村 龍

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • Development of pharmacological therapy of ARDS by drug repositioning

    Grant number:19K09381  2019.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    TAKAHASHI TORU

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    Despite recent progress in critical care, there have been no pharmacological modalities against acute organ injury although supportive therapeutic modalities have been developed. Drug repositioning, which is a process of identifying new therapeutic use(s) for old/existing/available drugs, has become a popular strategy in recent years. It is an effective strategy in discovering or developing drug molecules with new pharmacological/therapeutic indications. Although tin chloride is not a drug but a heavy metal toxic to humans it is known that tin chloride induces heme oxygenase-1; a stress protein, in a kidney specific manner. We administered tin chloride to a rat model of rhabdomyolysis-induced acute kidney injury produced by glycerol injection and examined its effect on the kidney injury. We found that tin chloride treatment significantly ameliorates the kidney injury by virtue of the induction of heme oxygenase-1 without any adverse effect in rats.

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  • 横紋筋融解症後腎傷害に対する細胞保護蛋白ヘムオキシゲナーゼ誘導による治療法の開発

    Grant number:18K08919  2018.04 - 2023.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    清水 裕子, 森松 博史, 井上 一由, 高橋 徹

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    急性腎傷害は救急・集中治療現場で遭遇することの多い病態の一つだが、特に地震・災害時などに遭遇する横紋筋融解症に伴う急性腎傷害では、初期治療の遅れから致死的状態を招くことがある。横紋筋融解症後の腎傷害の誘因であるミオグロビン由来の遊離ヘムの増加に対し、腎に細胞保護作用を持つHeme Oxygenase (HO)-1が誘導されることをNathらが報告している。申請者らは、ヘムを感知してHO-1発現を制御する転写調節因子である Bach1の細胞内動態変化を横紋筋融解症後腎傷害ラットモデルで初めて報告した。ヘムの分解酵素であり、抗酸化作用・抗炎症作用・抗アポトーシス作用を有するHO-1発現誘導による、 横紋筋融解症後腎傷害(RM-AKI)の新しい治療戦略を構築するために、本研究を立案した。
    2018年度は、RM-AKIに対する腎特異的HO-1誘導剤である塩化スズの腎保護効果を確認した。
    2019年度は、塩化スズによるHO-1の誘導機序を調べる目的で、ラットに塩化スズ100m/kgを皮下投与し、Sham(生食投与)群と比較しHO-1 mRNAは有意に上昇したが、細胞内ヘム上昇により発現が抑制されるALAS1 mRNAと、細胞内ヘム上昇により核内から細胞質へ移動すると考えられているが核内Bach1には有意な変動は見られなかった。また、今回の塩化スズの投与量では明らかな腎傷害は認めなかった。以上より、本モデルでは塩化スズはヘムの上昇を引き起こさない、より安全なHO-1誘導剤であることを確認した。
    2020年度は、腎上皮細胞(NRK-52E)に塩化スズを添加し、HO-1タンパクが塩化スズ容量依存的に、投与後12時間をピークに誘導されることを確認した。
    2021年度は、腎上皮細胞に塩化スズ添加後の核内外でのBach1タンパクの発現動態と、HO-1プロモーター領域の塩化スズの作用部位を検討した。

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  • 敗血症治療のためのHRG血液製剤の創出

    Grant number:19im0210109  2017.10 - 2020.03

    日本医療研究開発機構 (AMED)  医療分野研究成果展開事業  産学連携医療イノベーション創出プログラム 基本スキーム (ACT-M)

    西堀正洋, 和氣秀徳, 阪口政清, 宝田剛志, 勅使川原匡, 王登莉, 森松博史, 吉田道弘, 伊藤浩和, 上園昭人, 村上弘次, 前野英毅, 須加智也, 小林不二夫, 福永裕樹

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  • The role of mitophagy in the therapy of CO-releasing molecule against acute respiratory distress syndrome

    Grant number:16K10972  2016.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Takahashi Toru

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

    Even after successful resuscitation, hemorrhagic shock due to trauma and massive surgical bleeding, etc.,is known to induce a pulmonary inflammatory response that leads to acute lung injury, which is referred to as acute respiratory distress syndrome (ARDS). Although lung protective ventilation has been proposed for the treatment of ARDS in clinical settings, there is no definitive pharmacological therapy to prevent pulmonary inflammation in ARDS. Carbon monoxide (CO) is widely known to be a toxic gaseous molecule that produces carboxyhemoglobin due to its higher affinity to hemoglobin. However,carbon monoxide-releasing molecule-3 (CORM-3) has been reported to liberate and deliver extremely low amount of CO under physiological conditions, which exerts organ-protective effects during systemic insults. In the present study, we demonstrated that CORM-3 confers protection against hemorrhagic shock-induced ARDS mediated through its anti-inflammatory property in rats.

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Class subject in charge

  • Research Presentation in Preventive Medicine (2024academic year) special  - その他

  • Essays on pain (2024academic year) Second semester  - 月1~2

  • Primer for Clinical Medicine (2024academic year) special  - その他

  • Introduction to Clinical Medicine and Dentistry (2024academic year) Concentration  - その他

  • Elective Clinical Practice (Anesthesilogy and Resuscitology) (2024academic year) special  - その他

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