Faculty Profiles - Umakoshi Noriyuki

Papers - Umakoshi Noriyuki

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Comparison of robotic versus manual needle insertion for CT-guided intervention: prospective randomized trial

Takao Hiraki, Yusuke Matsui, Jun Sakurai, Koji Tomita, Mayu Uka, Soichiro Kajita, Noriyuki Umakoshi, Toshihiro Iguchi, Michihiro Yoshida, Kota Sakamoto, Takayuki Matsuno, Tetsushi Kamegawa

Radiology Advances 2 ( 2 ) 2025.3

Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

Abstract

Background

Robotic needle insertion under CT guidance has been developed, but data on comparison with manual insertion are still lacking.

Purpose

To compare robotic versus manual needle insertion for CT fluoroscopy-guided intervention, primarily in terms of insertion accuracy.

Materials and Methods

This was a prospective study between May 2020 and March 2023 at a single site. The cohort comprised 22 patients undergoing CT (Aquilion One or Aquilion CX; Canon Medical Systems) fluoroscopy-guided biopsy, who were randomly allocated to either the robotic or manual group. The robot used (Zerobot; Medicalnet Okayama) is not yet commercially available. A biopsy introducer needle was inserted by 1 of 3 physicians using a remote-control robot in the robotic group, versus by 1 of 3 different physicians by hand in the manual group. The primary endpoint was needle insertion accuracy, which was defined as the 3-dimensional Euclidean distance between a predetermined target point and the needle tip after insertion. The non-inferiority of robotic insertion to manual one was then tested. Adverse events were evaluated. Statistical comparisons were made between the 2 groups.

Results

Technical success and pathological findings were confirmed in all patients of the 2 groups. The mean and SD of needle insertion were 4.8 mm ± 2.6 in the robotic group and 7.0 mm ± 3.1 in the manual group (P &lt; .001). The mean difference in accuracy between the 2 groups (robotic minus manual group) was −2.1 mm (95% CI, −4.7 to 0.4). Effective dose to physicians was zero in all cases in the robotic group, while median dose was 1.0 µSv in the manual group (P &lt; .001). Dose length product to patients was not significantly different between the 2 groups (P = .100). No major adverse events were observed.

Conclusion

Robotic needle insertion was non-inferior to manual insertion in terms of accuracy, while it effectively eliminated radiation exposure to physicians.

Trial registration number

jRCT2062200013

DOI： 10.1093/radadv/umaf010

Other Link： https://academic.oup.com/radadv/article-pdf/2/2/umaf010/62871840/umaf010.pdf

Propensity score-matched analysis comparing robot-assisted partial nephrectomy and image-guided percutaneous cryoablation for cT1 renal cell carcinoma. Reviewed International journal

Tomoaki Yamanoi, Kensuke Bekku, Kasumi Yoshinaga, Yuki Maruyama, Kentaro Nagao, Tatsushi Kawada, Yusuke Tominaga, Noriyuki Umakoshi, Takuya Sadahira, Satoshi Katayama, Takehiro Iwata, Mayu Uka, Shingo Nishimura, Kohei Edamura, Tomoko Kobayashi, Yasuyuki Kobayashi, Takao Hiraki, Motoo Araki

Urologic oncology 42 ( 12 ) 453.e15-453.e22 2024.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: This study aimed to compare the clinical outcomes of robot-assisted partial nephrectomy (RAPN) and image-guided percutaneous cryoablation (IG-PCA) for clinical T1 renal cell carcinoma. MATERIALS AND METHODS: We conducted a retrospective analysis of 679 patients with clinical T1 renal cell carcinoma treated with RAPN or IG-PCA between 2012 and 2021. Propensity scores were calculated via logistic analysis to adjust for imbalances in baseline characteristics. We compared oncological and functional outcomes between the 2 treatment groups. RESULTS: Following the matching process, 108 patients were included in each group. No patient in the RAPN group developed local recurrence. In the IG-PCA group, three patients experienced local tumor progression. The patients underwent salvage thermal ablations by the secondary technique; 2 underwent IG-PCA and 1 underwent microwave ablation, resulting in a local control rate of 100%. The Kaplan-Meier analysis showed no statistically significant differences between the groups in terms of 5-year recurrence-free survival, metastasis-free survival, and overall survival (log-rank test; P = 0.11, P = 0.64, and P = 0.17, respectively). No significant differences were observed in the 2 treatments in major and overall complication rates (P = 0.75 and P = 0.82, respectively). Both groups showed similar rates of less than 10% estimated glomerular filtration rate decline at 12 months post-treatment and 5-year renal function preservation rates (P = 0.88 and P = 0.38, respectively). CONCLUSIONS: IG-PCA demonstrated oncological outcomes comparable to those of RAPN. RAPN addressed the disadvantages of conventional procedures and allowed for safety outcomes comparable to IG-PCA.

DOI： 10.1016/j.urolonc.2024.09.012

Evaluation of a novel central venous access port for direct catheter insertion without a peel-away sheath. Reviewed

Toshihiro Iguchi, Takahiro Kawabata, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Soichiro Okamoto, Kazuaki Munetomo, Takao Hiraki

Japanese journal of radiology 2024.9

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study retrospectively evaluated the feasibility and safety of implanting a newly developed central venous access port (CV-port) that allows catheter insertion into a vein without the use of a peel-away sheath, with a focus on its potential to minimize risks associated with conventional implantation methods. MATERIALS AND METHODS: All procedures were performed using a new device (P-U CelSite Port™ MS; Toray Medical, Tokyo, Japan) under ultrasound guidance. The primary endpoint was the implantation success rate. The secondary endpoints were the safety and risk factors for infection in the early postprocedural period (< 30 days). RESULTS: We assessed 523 CV-port implantations performed in a cumulative total of 523 patients (240 men and 283 women; mean age, 61.6 ± 13.1 years; range, 18-85 years). All implantations were successfully performed using an inner guide tube and over-the-wire technique through 522 internal jugular veins and one subclavian vein. The mean procedural time was 33.2 ± 10.9 min (range 15-112 min). Air embolism, rupture/perforation of the superior vena cava, or hemothorax did not occur during catheter insertion. Eleven (2.1%) intraprocedural complications occurred, including Grade I arrhythmia (n = 8) and subcutaneous bleeding (n = 1), Grade II arrhythmia (n = 1), and Grade IIIa pneumothorax (n = 1). Furthermore, 496 patients were followed up for ≥ 30 days. Six early postprocedural complications were encountered (1.1%), including Grade IIIa infection (n = 4), catheter occlusion (n = 1), and skin necrosis due to subcutaneous leakage of trabectedin (n = 1). These six CV-ports were withdrawn, and no significant risk factors for infection in the early postprocedural period were identified. CONCLUSION: The implantation of this CV-port device demonstrated comparable success and complication rates to conventional devices, with the added potential benefit of eliminating complications associated with the use of a peel-away sheath.

DOI： 10.1007/s11604-024-01658-5

Portal Venous Thrombosis after Percutaneous Cryoablation for Renal Cell Carcinoma Reviewed

Takahiro Kawabata, Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takao Hiraki

Journal of Kidney Cancer and VHL 11 ( 2 ) 39 - 42 2024.7

Publishing type：Research paper (scientific journal) Publisher：Codon Publications

A 50-year-old man with von Hippel–Lindau disease underwent cryoablation (CRA) for two adjacent renal cell carcinomas in the upper pole of his right kidney. Although computed tomography (CT) immediately after CRA revealed involvement of part of the liver parenchyma in the ice-ball, the treatment was completed without complications. Contrast-enhanced CT on day 2 post-CRA revealed a thrombus in the portal vein of segment 6 near the ablated liver parenchyma, prompting the initiation of oral anticoagulation. The patient was discharged on day 4 after CRA without any sequelae, and a follow-up contrast-enhanced CT done 6 weeks later demonstrated resolution of the portal vein thrombus.

DOI： 10.15586/jkcvhl.v11i2.347

Other Link： https://jkcvhl.com/index.php/jkcvhl/article/download/347/566

Is cryoablation a valid option for renal cell carcinomas in direct contact with critical organs? Reviewed International journal

Shoma Nagata, Yusuke Matsui, Koji Tomita, Mayu Uka, Takahiro Kawabata, Noriyuki Umakoshi, Kazuaki Munetomo, Maria Kawada, Toshihiro Iguchi, Takao Hiraki

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy 1 - 9 2024.5

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study aimed to assess the outcomes of percutaneous cryoablation (PCA) for renal cell carcinomas (RCCs) contacting critical organs without intervening fat tissue. MATERIAL AND METHODS: Twenty-three patients with 24 RCCs (mean size, 28.8 mm) contacting critical organs on preprocedural images were included. The organ displacement techniques, technical success, efficacy, and adverse events per Clavien-Dindo classification were retrospectively reviewed. RESULTS: The organs contacting the RCCs included the colon (n = 16), pancreas (n = 3), duodenum (n = 3), small intestine (n = 1), and stomach (n = 1). In all procedures, hydrodissection was conducted, and probe traction was additionally utilized in one to displace organs. Two procedures were terminated with an insufficient ice-ball margin (<6 mm) due to recurring proximity of the colon or thermal sink effect by renal hilar vessels, yielding a technical success rate of 91.6% (22/24). No severe adverse events were noted. All patients were alive without any metastases during a median follow-up of 34.4 months. The primary and secondary technical efficacy rates were 91.6% (22/24) and 95.8% (23/24) of tumors, respectively. CONCLUSION: PCA can be a valid option for RCCs contacting critical organs with a good safety profile and sufficient technical efficacy.

DOI： 10.1080/13645706.2024.2354332

Ablation of Kidney Tumors in Patients with Substantial Kidney Impairment: Current Status. Reviewed International journal

Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Hideo Gobara, Motoo Araki, Takao Hiraki

Current oncology reports 2024.4

Language：English Publishing type：Research paper (scientific journal)

PURPOSE OF REVIEW: To review the current status of kidney tumor ablation in patients with substantial kidney impairment. RECENT FINDINGS: Few reports of kidney tumor ablation in such patients have recently been published. The reported prevalence of patients with stage 4 or 5 chronic kidney disease (CKD) among patients undergoing ablation is 2.0%-10%. In patients with stage 4 or 5 CKD, local tumor control rates were 88%-100%. The effect of ablation on CKD stage is unclear, and the observed deteriorations in kidney function are consistent with both the effect of cryoablation and the natural course of advanced CKD. According to guidelines, active surveillance may be selected. The goals of treatment are complete tumor removal and maintenance of kidney function, both of which can be met by ablation. Given the limited treatment options, ablation may play a pivotal role in the management of patients with advanced CKD.

DOI： 10.1007/s11912-024-01533-6

Depiction rate of feeding arteries of renal cell carcinoma on four-dimensional computed tomography angiography. Reviewed

Kazuaki Munetomo, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Yusuke Morimitsu, Toshihiro Iguchi, Takao Hiraki

Japanese journal of radiology 2024.2

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To retrospectively evaluate the depiction rate of feeding arteries in biopsy-proven clear cell renal cell carcinoma (CCRCC) on four-dimensional computed tomography angiography (4D-CTA) images. MATERIALS AND METHODS: This study included 22 patients with 22 CCRCC and 30 feeding arteries treated with transcatheter renal artery embolization. The depiction rate of the feeding arteries on preprocedural 4D-CTA was evaluated. Images were acquired by 320-row multi-detector computed tomography (CT) 15‒36 s after starting to inject a contrast agent (600 mg/kg iodine) intravenously into patients at 2.1 s intervals (11 phases). Two board-certified radiologists retrospectively assessed the feeder depiction rate in all 11 phases with reference to the procedural images as the gold standard. Discrepancies were resolved by consultation with a third radiologist. RESULTS: Among the feeders, 11 (36.7%) were segmental or lobar, and 19 (63.3%) were interlobar or arcuate arteries. The feeder depiction rate was the highest (25 [83.3%] of 30) in the 5th phase (delay, 23.4 s) where the gap in contrast enhancement between the renal artery and cortex was the largest. This was followed by the 6th (23 [76.7%] of 30), 4th (22 [73.3%] of 30]), and 7th (21 [70.0%] of 30) phases. The overall rate of depicting feeding arteries in the 11 phases of 4D-CTA was 28 (93.3%) of 30. CONCLUSIONS: The depiction rate of CCRCC feeding arteries including lobar or smaller artery branches by 4D-CTA was favorable. The feeding arteries were optimally visualized during the phase with the largest contrast gap between the renal artery and cortex.

DOI： 10.1007/s11604-024-01538-y

腎癌に対してRFAを行った1例

平井唯隆, 冨田晃司, 宇賀麻由, 馬越紀行, 川端隆寛, 松井裕輔, 平木隆夫, 宗友一晃, 生口俊浩

Japanese Journal of Radiology 42 ( Suppl. ) 47 - 47 2024.2

Arterial embolization via retrograde approach using steerable microcatheter and triaxial system. Reviewed International journal

Takahiro Kawabata, Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Shoma Nagata, Takao Hiraki

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy 1 - 3 2024.1

Language：English Publishing type：Research paper (scientific journal)

We report a case of postoperative pseudoaneurysm, successfully treated with selective arterial embolization, using a steerable microcatheter and triaxial system via retrograde approach. A pseudoaneurysm was detected in the dorsal pancreatic artery, a severely narrow and steeply inverted branch of the superior mesenteric artery, making microcatheter insertion via the antegrade approach challenging. However, a steerable microcatheter was advanced beyond the orifice and the tip was reversed, changing the route to retrograde allowing for easy insertion of the microguidewire. Subsequently, a small microcatheter was advanced beyond the pseudoaneurysm into the dorsal pancreatic artery, and arterial embolization was successfully completed without complications.

DOI： 10.1080/13645706.2024.2302567

Clinical T1a Renal Cell Carcinoma with Solitary Diaphragmatic Metastasis in a Patient with von Hippel-Lindau Disease. Reviewed International journal

Tadataka Hirai, Mayu Uka, Toshihiro Iguchi, Kazuya Yasui, Takahiro Kawabata, Noriyuki Umakoshi, Koji Tomita, Yusuke Matsui, Yasuyuki Kobayashi, Motoo Araki, Takao Hiraki

Journal of kidney cancer and VHL 11 ( 3 ) 23 - 26 2024

Language：English Publishing type：Research paper (scientific journal)

We report the case of a 38-year-old man with two von Hippel-Lindau disease-associated T1a renal cell carcinomas (RCCs) (<2 cm in diameter) which developed into a 2.5-cm solitary diaphragmatic metastatic tumor. After diagnosis using percutaneous biopsy, the diaphragmatic metastasis and two RCCs were treated by laparoscopic resection and percutaneous cryoablation, respectively. One year after treatment, the patient survived without local recurrence or distant metastasis. This report describes a rare case of RCC metastasis in VHL disease and its treatment.

DOI： 10.15586/jkcvhl.v11i3.342

Automated Feeder-Detection Software for Renal Cell Carcinoma Embolization: A Retrospective Evaluation of Detection Rate Using Transarterial Time-Resolved Computed Tomography Angiography. Reviewed International journal

Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Akira Kurozumi, Ayako Ujifuku, Toshihiro Iguchi, Takao Hiraki

Cardiovascular and interventional radiology 2023.11

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To evaluate the detection rate of feeding arteries in renal cell carcinoma with automated feeder-detection software and determine the optimal imaging phase for accurate feeder detection with transarterial time-resolved computed tomography angiography. MATERIALS AND METHODS: The performance of automated feeder-detection software was retrospectively evaluated using transarterial renal time-resolved computed tomography angiography images of 15 renal cell carcinomas (mean size, 22.1 mm); the images were obtained via the renal artery using a hybrid angio-CT system with 320-row computed tomography, across nine phases with 0.5-s intervals over a contrast delay time of 1.0-5.0 s. Automated feeder-detection software was applied to each phase in all tumors (135 image series in total). The feeder-detection rate (i.e., sensitivity) in each phase was evaluated, and the number of false feeders demonstrated by the software was counted for each tumor. RESULTS: A total of 22 feeders were identified. The feeder-detection rate was the highest (95.5% [21/22]) at delay times of 1.5 s and 2.0 s and lower in later phases. At delay times of 1.0 s and 1.5 s, the software demonstrated no or only a few (≤ 3) false feeders in 93.3% (14/15) of the tumors. In later phases, however, many (≥ 4) false feeders were observed in > 50% of tumors. CONCLUSION: The automated feeder-detection software showed a favorable feeder-detection rate and may be useful in transarterial embolization for renal cell carcinoma. The optimal delay time to avoid the demonstration of false feeders and achieve a high detection accuracy was 1.5 s. LEVEL OF EVIDENCE IV: Case Series.

DOI： 10.1007/s00270-023-03611-x

Time course of complications after small renal mass biopsy: evaluation of initial follow-up images. Reviewed

Soichiro Kajita, Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Takao Hiraki

Japanese journal of radiology 2023.11

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To retrospectively assess the time course of complications after image-guided small renal mass biopsy using initial follow-up imaging. MATERIALS AND METHODS: A total of 190 masses (mean, 2.1 ± 0.70 cm; range, 0.6-3.8 cm) were assessed using initial computed tomography (43 non-enhanced and 141 enhanced) or magnetic resonance imaging (five non-enhanced and one enhanced) after biopsy. Initial follow-up imaging was classified into two groups (i.e., with or without hematoma) and various factors were compared. RESULTS: The masses were histologically diagnosed in all patients except one. Post-procedural complications included 129 Grade I hematomas, 1 Grade I hemothorax, 9 Grade II hematomas, and 1 Grade IIIa pneumothorax. Residual 28 Grade I and 6 Grade II hematomas and 8 new complications (6 small hematomas, 1 pseudoaneurysm, and 1 arteriovenous fistula) were observed on the initial follow-up imaging obtained at a median of 21 days (3-90 days) after the biopsy. On the initial follow-up imaging, the groups with and without hematoma differed significantly in the following factors: age (P = 0.04), size (P = 0.02), guided images (P < 0.01), hematoma at the end of the procedure (P < 0.01), and days after biopsy (P < 0.01). Although three masses exhibited > 25% shrinkage, no significant change was observed in mass diameter on initial follow-up imaging (mean, 2.1 ± 0.71 cm; P = 0.90). CONCLUSION: Initial follow-up imaging after a biopsy revealed improvements in most of the complications, a few new complications, and an unchanged mass diameter.

DOI： 10.1007/s11604-023-01509-9

Prospective evaluation of core number of biopsy for renal tumor: are multiple cores preferable? Reviewed

Toshihiro Iguchi, Yusuke Matsui, Tomohiro Toji, Jun Sakurai, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Toshiharu Mitsuhashi, Takao Hiraki

Japanese Journal of Radiology 82回 S160 - S160 2023.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Purpose

This single-center, single-arm, prospective, open-label study was conducted to evaluate the optimal number of cores (single or multiple) in renal tumor biopsy.

Materials and methods

Forty-four biopsies of 44 tumors (mean diameter, 2.7 ± 1.0 cm; range, 1.6–5.0 cm) were included. Biopsy was performed under ultrasound or computed tomography fluoroscopy guidance using an 18-gauge cutting needle and the co-axial method. Two or more specimens were obtained, which were divided into first and subsequent specimens. “First specimen” and “all specimens” were histologically evaluated (i.e., appropriateness of specimen, histological diagnosis, subtype, and Fuhrman grade of renal cell carcinoma [RCC]) blindly and independently by two board-certified pathologists.

Results

Multiple specimens were successfully and safely obtained in all the biopsies. All tumors were histologically diagnosed; 40 malignancies included 39 RCCs and 1 solitary fibrous tumor, and 4 benign lesions included 2 angiomyolipomas, 1 oncocytoma, and 1 capillary hemangioma. In all RCCs, the subtype could be determined (32 clear cell RCCs, 4 chromophobe RCCs, and 3 papillary RCCs), and the Furman grade was determined in 38 RCCs. When only the first specimen was evaluated, 22.7% of the specimens were inappropriate for diagnosis, and 34 (77.3%) were histologically diagnosed. The diagnostic yield was significantly lower than that of all specimens (P = 0.0044). Univariate analysis revealed that smaller lesions were a significant predictor of diagnostic failure (P = 0.020).

Conclusion

Biopsy with multiple cores significantly improved diagnostic yield. Thus, operators should obtain multiple cores during renal tumor biopsy.

DOI： 10.1007/s11604-023-01496-x

Other Link： https://link.springer.com/article/10.1007/s11604-023-01496-x/fulltext.html

Image-Guided Ablation Therapies for Extrahepatic Metastases from Hepatocellular Carcinoma: A Review Reviewed

Noriyuki Umakoshi, Yusuke Matsui, Koji Tomita, Mayu Uka, Takahiro Kawabata, Toshihiro Iguchi, Takao Hiraki

Cancers 15 ( 14 ) 3665 - 3665 2023.7

Publishing type：Research paper (scientific journal) Publisher：MDPI AG

The most common sites of extrahepatic metastases from hepatocellular carcinoma (HCC) are the lungs, intra-abdominal lymph nodes, bones, and adrenal glands, in that order. Although systemic therapies are a common treatment for patients with extrahepatic metastases, local ablative therapies for the extrahepatic metastatic lesions can be performed in selected patients. In this article, the literature on image-guided thermal ablation for metastasis to each organ was reviewed to summarize the current evidence. Radiofrequency ablation was the most commonly evaluated technique, and microwave ablation, cryoablation, and percutaneous ethanol injection were also utilized. The local control rate of thermal ablation therapy was relatively favorable, at approximately 70–90% in various organs. The survival outcomes varied among the studies, and several studies reported that the absence of viable intrahepatic lesions was associated with improved survival rates. Since only retrospective data from relatively small studies has been available thus far, more robust studies with prospective designs and larger cohorts are desired to prove the usefulness of thermal ablation for extrahepatic metastases from HCC.

DOI： 10.3390/cancers15143665

Robotic systems in interventional oncology: a narrative review of the current status Reviewed

Yusuke Matsui, Tetsushi Kamegawa, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Toshihiro Iguchi, Takayuki Matsuno, Takao Hiraki

International Journal of Clinical Oncology 2023.4

Renal cryoablation combined with prior transcatheter arterial embolization in non-dialysis patients with stage 4 or 5 chronic kidney disease: a retrospective study Reviewed

Noriyuki Umakoshi, Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Hideo Gobara, Motoo Araki, Takao Hiraki

Japanese Journal of Radiology 2023.4

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Purpose

To retrospectively evaluate cryoablation combined with prior transcatheter arterial embolization (TAE) for renal cell carcinoma (RCC) in non-dialysis patients with stage 4 or 5 chronic kidney disease (CKD).

Materials and methods

Patients with stage 4 or 5 CKD undergoing TAE and cryoablation for RCC between May 2012 and October 2021 were included. TAE was selectively performed using iodized oil with absolute ethanol or gelatin sponge 1–14 days before cryoablation. Local efficacy, safety, and changes in renal function were evaluated.

Results

Nine patients (seven men and two women; median age, 64 years; range 52–88 years) with nine RCCs (mean diameter, 3.0 ± 1.0 cm; range 1.7–4.7 cm) were included. The mean pre-treatment estimated glomerular filtration rate (eGFR) was 24.2 ± 5.6 ml/min/1.73 m² (range 10.4–29.2 ml/min/1.73 m²). The mean amount of contrast medium used in TAE was 58 ± 29 ml (range 40–128 ml). Except in one patient (grade 3 pyelonephritis), no grade ≥ 3 complications occurred. During the follow-up period (median, 18 months; range 7–54 months), no local tumor progression occurred. In two patients with pre-treatment eGFR of < 20 ml/min/1.73 m², hemodialysis was initiated at 3 and 19 months after cryoablation. At their last follow-up, the remaining seven patients showed a decrease of 6.2 ± 5.3 ml/min/1.73 m² (range 0.7–17.2 ml/min/1.73 m²) in their eGFR.

Conclusion

Cryoablation combined with TAE for RCC in non-dialysis patients with stage 4 or 5 CKD was effective and safe, with an acceptable impact on renal function.

DOI： 10.1007/s11604-023-01416-z

Other Link： https://link.springer.com/article/10.1007/s11604-023-01416-z/fulltext.html

Complications of Percutaneous Cryoablation for Renal Tumors and Methods for Avoiding Them. Reviewed

Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Motoo Araki, Takao Hiraki

Acta medica Okayama 77 ( 2 ) 121 - 129 2023.4

Language：English Publishing type：Research paper (scientific journal)

Percutaneous cryoablation of renal tumors is widely used because of its high efficacy and safety. This high safety can be attributed, at least in part, to the visibility of the ablated area as an "ice ball". This therapy has fewer complications (incidence, 0-7.2%) and is less invasive than surgery. Minor bleeding is inevitable in most kidney-related procedures, and indeed the most common complication of this therapy is bleeding (hematoma and hematuria). However, patients require treatment such as transfusion or transarterial embolization in only 0-4% of bleeding cases. Various other complications such as ureteral or collecting system injury, bowel injury, nerve injury, skin injury, infection, pneumothorax, and tract seeding also occur, but they are usually minor and asymptomatic. However, operators should know and avoid the various complications associated with this therapy. This study aimed to summarize the complications of percutaneous cryoablation for renal tumors and provide some techniques for achieving safe procedures.

DOI： 10.18926/AMO/65141

cT1腎癌におけるロボット支援腎部分切除(RAPN)と経皮的凍結療法(PCA)の傾向スコアマッチング解析を用いた周術期成績・術後腎機能の検討(Oncological outcomes and renal function in robot-assisted partial nephrectomy vs percutaneous cryoablation for cT1 RCC: A propensity score-matched analysis)

山野井友昭, 別宮謙介, 馬越紀行, 定平卓也, 片山聡, 岩田健宏, 宇賀麻由, 西村慎吾, 枝村康平, 小林知子, 小林泰之, 荒木元朗, 平木隆夫

日本泌尿器科学会総会 110回 PP75 - 01 2023.4

男性IVR医の育児休暇取得による配偶者の育児ストレス軽減についての検討

馬越紀行, 松井裕輔, 冨田晃司, 宇賀麻由, 川端隆寛, 宗友一晃, 永田翔馬, 平木隆夫

日本インターベンショナルラジオロジー学会雑誌 38 ( Suppl. ) 238 - 238 2023.4

化膿性脊椎炎・椎間板炎に対するCTガイド下経皮的針生検および穿刺吸引の検討

宗友一晃, 松井裕輔, 冨田晃司, 宇賀麻由, 川端隆寛, 馬越紀行, 生口俊浩, 平木隆夫

日本インターベンショナルラジオロジー学会雑誌 38 ( Suppl. ) 229 - 229 2023.4

腎癌に対する経皮的凍結療法とロボット支援下腎部分切除術の対費用効果についての後方視的比較検討(Percutaneous Cryoablatin vs Robot-Assisted Partial Nephrectomy in Renal Carcinoma: Cost Analysis)

宇賀麻由, 別宮謙介, 山野井友昭, 永田翔馬, 宗友一晃, 馬越紀行, 川端隆寛, 冨田晃司, 松井裕輔, 生口俊浩, 郷原英夫, 荒木元朗, 平木隆夫

日本インターベンショナルラジオロジー学会雑誌 38 ( Suppl. ) 211 - 211 2023.4

高リスク隣接臓器が接触した腎悪性腫瘍に対する経皮的凍結療法(Percutaneous Cryoablation for Malignant Renal Tumors Contacting with High-risk Adjacent Organs)

Nagata Shoma, Matsui Yusuke, Tomita Koji, Uka Mayu, Umakoshi Noriyuki, Kawabata Takahiro, Munetomo Kazuaki, Iguchi Toshihiro, Hiraki Takao

日本医学放射線学会学術集会抄録集 82回 S160 - S160 2023.3

転移性腎腫瘍に対する経皮的凍結療法安全性と有効性の後方視的評価(Percutaneous Cryoablation for Metastatic Renal Tumors: A Retrospective Evaluation of Safety and Efficacy)

Kawabata Takahiro, Matsui Yusuke, Tomita Koji, Uka Mayu, Umakoshi Noriyuki, Munetomo Kazuaki, Nagata Shoma, Iguchi Toshihiro, Hiraki Takao

日本医学放射線学会学術集会抄録集 82回 S160 - S160 2023.3

下腿に発生した多発性グロムス腫瘍の1例

衣笠里菜, 馬越紀行, 浅野雄大, 児島克英, 檜垣文代, 槇本怜子, 大川七子, 松井裕輔, 平木隆夫

Japanese Journal of Radiology 41 ( Suppl. ) 48 - 48 2023.2

鼠径部高位穿刺による外腸骨動脈損傷に対し,バイアバーンを留置し救命しえた1例

櫻井淳暢, 宗友一晃, 冨田晃司, 永田翔馬, 川端隆寛, 馬越紀行, 宇賀麻由, 松井裕輔, 生口俊浩, 平木隆夫

日本インターベンショナルラジオロジー学会雑誌 37 ( 1 ) 58 - 58 2023.2

パワードライバー骨生検針の初期使用経験

高橋優花, 馬越紀行, 永田翔馬, 宗友一晃, 川端隆寛, 宇賀麻由, 冨田晃司, 松井裕輔, 生口俊浩, 平木隆夫

日本インターベンショナルラジオロジー学会雑誌 37 ( 1 ) 59 - 59 2023.2

経皮的ドレナージにて治療しえた大網膿瘍の1例

山田実典, 宇賀麻由, 宗友一晃, 馬越紀行, 冨田晃司, 松井裕輔, 生口俊浩, 平木隆夫, 垣内慶彦, 黒田新士

Japanese Journal of Radiology 41 ( Suppl. ) 41 - 41 2023.2

腎生検で診断された腎良性腫瘍の2例

白石明日香, 宗友一晃, 山田実典, 永田翔馬, 馬越紀行, 川端隆寛, 宇賀麻由, 冨田晃司, 松井裕輔, 生口俊浩, 平木隆夫

Japanese Journal of Radiology 41 ( Suppl. ) 41 - 41 2023.2

多発脾動脈瘤の1例

馬越紀行, 松井裕輔, 宗友一晃, 宇賀麻由, 冨田晃司, 生口俊浩, 平木隆夫

Japanese Journal of Radiology 41 ( Suppl. ) 41 - 41 2023.2

経皮的鼠径リンパ節穿刺によるリンパ管塞栓術が奏功した難治性リンパ漏の2例

衣笠里菜, 宇賀麻由, 宗友一晃, 馬越紀行, 川端隆寛, 冨田晃司, 松井裕輔, 生口俊浩, 平木隆夫

日本インターベンショナルラジオロジー学会雑誌 37 ( 1 ) 60 - 60 2023.2

腎癌定位放射線治療のフィデューシャルマーカーとして血管内コイルを留置した2例

永田翔馬, 冨田晃司, 宇賀麻由, 井原弘貴, 馬越紀行, 川端隆寛, 宗友一晃, 衣笠里菜, 山田実典, 松井裕輔, 吉尾浩太郎, 杉山聡一, 平木隆夫, 生口俊浩

Japanese Journal of Radiology 41 ( Suppl. ) 49 - 49 2023.2

診療科横断的アプローチにより救命し得た外傷性大動脈解離および肝損傷の1例

武川真也, 宇賀麻由, 永田翔馬, 宗友一晃, 馬越紀行, 川端隆寛, 冨田晃司, 松井裕輔, 生口俊浩, 平木隆夫, 内藤宏道, 上田浩平, 廣田真規

Japanese Journal of Radiology 41 ( Suppl. ) 47 - 47 2023.2

Magnetic Resonance Imaging Guidance for Percutaneous Needle Intervention Reviewed

Mayu Uka, Yusuke Matsui, Toshihiro Iguchi, Toshi Matsushita, Koji Tomita, Noriyuki Umakoshi, Takahiro Kawabata, Masanori Yamada, Takao Hiraki

Interventional Radiology 2023

Correction to: Correlation between renal ablation zone in contrast‑enhanced CT and non‑enhanced MRI during the early period following percutaneous cryoablation.

Noriyuki Umakoshi, Toshihiro Iguchi, Takao Hiraki, Yusuke Matsui, Koji Tomita, Mayu Uka, Soichiro Kajita, Motoo Araki, Toshiharu Mitsuhashi, Hideo Gobara, Susumu Kanazawa

Japanese journal of radiology 40 ( 12 ) 1316 - 1316 2022.12

Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade

Koji Tomita, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Toshihiro Iguchi, Takao Hiraki

Japanese Journal of Radiology 40 ( 10 ) 1035 - 1045 2022.9

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Purpose

This review aimed to summarize the treatment outcomes of percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for metastatic liver tumors based on the findings of published studies over the last decade.

Materials and methods

Literature describing the survival outcomes of ablation therapy for liver metastases was explored using the PubMed database on April 26, 2022, and articles published in 2012 or later were selected. The included studies met the following criteria: (i) English literature, (ii) original clinical studies, and (iii) literature describing overall survival (OS) of thermal ablation for metastatic liver tumors. All case reports and cohort studies with fewer than 20 patients and those that evaluated ablation for palliative purposes were excluded.

Results

RFA was the most commonly used method for ablation, while MWA was used in several recent studies. RFA and MWA for liver metastases from various primary tumors have been reported; however, majority of the studies focused on colorectal cancer. The local control rate by RFA and MWA varied widely among the studies, ranging approximately 50–90%. Five-year survival rates of 20–60% have been reported following ablation for colorectal liver metastases by a number of studies, and several reports of 10-year survival rates were also noted.

Conclusion

Comparative studies of local therapies for colorectal liver metastases demonstrated that RFA provides comparable survival outcomes to surgical metastasectomy and stereotactic body radiation therapy.

DOI： 10.1007/s11604-022-01335-5

Other Link： https://link.springer.com/article/10.1007/s11604-022-01335-5/fulltext.html

Percutaneous cryoablation combined with prior transcatheter arterial embolization for renal cell carcinomas of 3 cm or larger: a prospective study

Hideo Gobara, Yusuke Matsui, Mayu Uka, Koji Tomita, Noriyuki Umakoshi, Motoo Araki, Jun Sakurai, Toshihiro Iguchi, Takao Hiraki

International Journal of Clinical Oncology 27 ( 10 ) 1589 - 1595 2022.8

植込み型除細動器(ICD)リード交換後に生じた内胸動脈-腕頭静脈シャント塞栓術の1例

馬越紀行, 宇賀麻由, 宗友一晃, 小牧稔幸, 冨田晃司, 松井裕輔, 櫻井淳, 生口俊浩, 郷原英夫, 平木隆夫, 金澤右

日本インターベンショナルラジオロジー学会雑誌 36 ( 3 ) 320 - 320 2022.8

Clinical outcomes of image-guided percutaneous drainage of pericardial effusion in cancer patients: A single-center retrospective analysis. Reviewed International journal

Tetsuya Hasegawa, Yasuaki Arai, Miyuki Sone, Shunsuke Sugawara, Chihiro Itou, Shinji Wada, Noriyuki Umakoshi, Takatoshi Kubo, Shintaro Kimura, Masahiko Kusumoto

Asia-Pacific journal of clinical oncology 2022.7

Language：English Publishing type：Research paper (scientific journal)

AIM: Catheter removal, survival, and recurrence rates after percutaneous pericardial effusion drainage in cancer patients are not fully understood. We evaluated the clinical outcomes of image-guided percutaneous pericardial effusion drainage in cancer patients. METHODS: From January 2014 to September 2017, 113 percutaneous drainages for symptomatic pericardial effusion were performed in 100 cancer patients (median 60 years; range, 7-84 years) using ultrasound or angio-computed tomography. An 8-Fr drainage catheter was placed using the Seldinger technique via the subxiphoid (n = 73), apical (n = 23), or left parasternal (n = 17) routes. Success rates, complications, and postprocedural clinical outcomes of drainages were retrospectively assessed. RESULTS: The technical and clinical success rates were 100% and 99%, respectively, without major complications. The median duration of catheterization and evacuated pericardial effusion volume were 6 days (range, 1-72 days) and 970 ml (range, 140-7635 ml), respectively. Catheters were removed after the first drainage in 86 cases (86%). Symptomatic pericardial effusion recurred in nine patients after catheter removal, in whom redrainages were performed 13 times with a median duration to redrainage time of 48 days (range, 13-529 days). During the follow-up period (median 106 days [range, 1-1396 days]), 61 patients died. The median survival was 140 days (95% confidence interval [CI], 95-276 days), and the median catheter-free survival was 111 days (95% CI, 60-152 days). CONCLUSIONS: Image-guided percutaneous pericardial effusion drainage for cancer patients is safe and helps alleviate symptoms. Additionally, catheter removal is possible in most patients, allowing a catheter-free period for patients.

DOI： 10.1111/ajco.13810

Up-to-date evidence on image-guided thermal ablation for metastatic lung tumors: a review

Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Toshihiro Iguchi, Takao Hiraki

Japanese Journal of Radiology 40 ( 10 ) 1024 - 1034 2022.7

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

The aim of this review was to summarize the latest evidence on image-guided thermal ablation therapies for lung metastases. PubMed was used to search for relevant articles that reported the oncological outcomes of thermal ablation for metastatic lung tumors, and those published in 2010 or later were selected for review. Ablative therapies were applied for lung metastases from various types of primary tumors, but most commonly colorectal ones. Radiofrequency ablation (RFA) was the most evaluated technique, followed by microwave ablation (MWA). The local control rates of ablative therapies were generally favorable, approximately 80–90% in many studies. Representative studies demonstrated promising overall survival rates of approximately 50% or higher 5 years after ablation for lung metastases from colorectal cancer or mixed types of primary tumors. Nevertheless, the survival outcomes varied depending on the type of primary tumor and background factors of patients such as other metastases and comorbidities. Several studies had aimed to compare the outcomes of various ablative therapies such as RFA, MWA, and cryoablation; however, conclusive data are not yet available to determine the most appropriate ablation modality for lung metastases. Further data accumulation is needed, especially for long-term outcomes and comparisons with other therapies.

DOI： 10.1007/s11604-022-01302-0

Other Link： https://link.springer.com/article/10.1007/s11604-022-01302-0/fulltext.html

Percutaneous cryoablation for clinical T3a renal cell carcinoma (< 7 cm) with segmental vein involvement or perinephric fat invasion based on preoperative evaluation of high-resolution multidetector computed tomography scan

Mayu Uka, Toshihiro Iguchi, Nanako Okawa, Yusuke Matsui, Koji Tomita, Noriyuki Umakoshi, Kazuaki Munetomo, Hideo Gobara, Motoo Araki, Takao Hiraki

Japanese Journal of Radiology 40 ( 11 ) 1201 - 1209 2022.6

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Purpose

To retrospectively assess the feasibility, safety, renal function, technique efficacy rate, and survival of patients with clinical T3a renal cell carcinoma (RCC).

Materials and methods

Sixteen cryoablation sessions were performed in 14 patients (10 men; mean age, 69.8 ± 10.5 years; range, 49–90 years) with 14 clear cell T3a RCCs (mean, 3.3 ± 0.9 cm; range, 1.9–5.2 cm). One patient was on dialysis. Transcatheter arterial embolization was performed before cryoablation in 15 sessions. The primary endpoint was the technique efficacy rate. The secondary endpoints included feasibility, safety, renal function, and survival.

Results

Cryoablation was technically successful in all RCC cases. In two RCCs, cryoablation was performed twice because of local tumor progression. No major adverse events were observed. All patients were alive without metastases, with a median follow-up of 45 months (6−93 months). Complete response was achieved by cryoablation in 11 RCCs (78.6%). The primary and secondary technique efficacy rates were 77.1% and 84.4% at 1 year, 57.9% and 73.9% at 3 years, and 57.9% and 73.9% at 5 years, respectively. One patient underwent dialysis given a total contralateral nephrectomy due to another RCC 1 month after initial cryoablation and a total ipsilateral nephrectomy 46 months after initial cryoablation due to local progression. Except for two dialysis patients, of the 12 patients with a median follow-up of 41 months (6–93 months), none were on dialysis.

Conclusion

Cryoablation was safe and effective in T3a RCC, which mainly involved the renal venous branches and may represent an alternative treatment for inoperable patients.

DOI： 10.1007/s11604-022-01297-8

Other Link： https://link.springer.com/article/10.1007/s11604-022-01297-8/fulltext.html

Early enlarging cavitation after percutaneous radiofrequency ablation of lung tumors: Incidence, risk factors and outcome. International journal

Koji Tomita, Toshihiro Iguchi, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Toshiharu Mitsuhashi, Jun Sakurai, Hideo Gobara, Susumu Kanazawa, Takao Hiraki

Diagnostic and interventional imaging 103 ( 10 ) 464 - 471 2022.5

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The purpose of this study was to retrospectively determine the incidence of early enlarging cavitation after percutaneous radiofrequency ablation (RFA) of lung tumor and identify risk factors associated with their occurrence. PATIENTS AND METHODS: A total of 245 patients (140 men, 105 women; mean age, 62.7 ± 11.8 [SD] years; age range: 31-87 years) with 605 lung tumors who were treated using 401 RFA sessions from April 2010 to March 2020 were included. Of which, 31 patients with 38 early enlarging cavitation and control group (151 patients with 228 tumors) were analyzed. Early enlarging cavitation was defined as cavities with an enlarged size (>3 cm) occurring on ablated lesions within seven days after RFA. Incidence of cavitation, risk and post-procedural factors of occurrence, major adverse events (AEs) that occurred in RFA sessions with cavitation, and course of cavitation were evaluated. AEs were classified using the CIRSE classification system for complications. RESULTS: Thirty-eight cavities (6.3%, 38/605 tumors) in 31 patients occurred in an average of 3.1 ± 1.7 days (range, 1-7 days) after 32 RFA sessions. Distance from pleura ≥ 20 mm, contact with vessel ≥ 3 mm, multitined expandable electrode ≥ 3 cm, and bronchus ≥ 2 mm encompassed in the ablation zone were independent risk factors of occurrence. Fever ≥ 38.5 °C, white blood cell count ≥ 10,000/μl one day after RFA, and steroid therapy were independent post-procedural factors of occurrence. Twenty-four Grade 3 and two Grade 6 AEs occurred. Twenty-nine cavities disappeared within a mean duration of 111.9 ± 64.9 (SD) days (range: 44-274 days) and four remained with a mean follow-up of 279.2 ± 174 (SD) days; five patients were lost to follow-up. CONCLUSIONS: Early enlarging cavitation occurs in 6.3% of lung tumors treated with RFA and are associated with 26 major AEs in 32 sessions. Aforementioned procedural factors and post-procedural inflammation were significant risk factors of occurrence.

DOI： 10.1016/j.diii.2022.05.004

Correlation between renal ablation zone in contrast-enhanced CT and non-enhanced MRI during the early period following percutaneous cryoablation.

Noriyuki Umakoshi, Toshihiro Iguchi, Takao Hiraki, Yusuke Matsui, Koji Tomita, Mayu Uka, Soichiro Kajita, Motoo Araki, Toshiharu Mitsuhashi, Hideo Gobara, Susumu Kanazawa

Japanese journal of radiology 40 ( 10 ) 1087 - 1095 2022.5

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To retrospectively evaluate and correlate the contrast-enhanced computed tomography (CECT) and non-enhanced magnetic resonance imaging (MRI) during the early period following renal cryoablation. MATERIALS AND METHODS: Both dynamic CECT and non-enhanced MRI were performed within 4 days following cryoablation in 34 renal tumors in 33 patients. The renal volumes of the unenhanced regions on dynamic CECT (nephrogenic phase, 4 mm thickness) and the regions with signal intensity changes on non-enhanced MRI (fat-suppressed T2-weighted image, 4 mm thickness) were evaluated. Fusion images of the axial, coronal, and sagittal sections of CECT and MRI images were created from the maximum cross-section of the renal tumor, and the match score of each image was visually evaluated on a 5-point scale. RESULTS: The mean renal volume of the unenhanced regions on CECT and those with signal intensity changes on non-enhanced MRI following cryoablation were 29.5 ± 19.9 cm3 (range, 4.3-97.4 cm3) and 30.7 ± 19.8 cm3 (range, 6.7-94.0 cm3), respectively; the difference between them was -1.17 cm3 (95% confidence interval [CI] -2.74, 0.40, P = 0.139). The Pearson's product-moment correlation coefficient (r = 0.975; 95% CI, 0.951, 0.988; P < 0.0001) showed a strong correlation between the volumes. The average match score between CECT and non-enhanced MRI was as high as 4.5 ± 0.5 points (radiologist 1, 4.3 ± 0.5; radiologist 2, 4.7 ± 0.5). Local tumor control rate was 94.1% (32/34 tumors) and recurrence-free survival rate was 82.0% (95% CI: 64.2%, 91.5%) at 5 years. CONCLUSIONS: The region with signal intensity changes on non-enhanced MRI was strongly correlated with the unenhanced region on CECT during the early period following renal cryoablation.

DOI： 10.1007/s11604-022-01285-y

In Vivo Microwave Ablation of Normal Swine Lung at High-power, Short-duration Settings.

Toshihiro Iguchi, Takao Hiraki, Yusuke Matsui, Tomohiro Toji, Mayu Uka, Koji Tomita, Toshiyuki Komaki, Noriyuki Umakoshi, Toshiharu Mitsuhashi, Susumu Kanazawa

Acta medica Okayama 76 ( 1 ) 57 - 62 2022.2

Language：English Publishing type：Research paper (scientific journal)

To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long- and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2- or 3-min ablation. There were no significant differences between the 2- and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neighboring bronchus might occur.

DOI： 10.18926/AMO/63212

CT fluoroscopy-guided biopsy of pulmonary lesions contacting the interlobar fissure: An analysis of 72 biopsies

Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Kazuaki Munetomo, Takao Hiraki

Diagnostic and Interventional Imaging 103 ( 6 ) 302 - 309 2022.2

CTガイド下生検で診断された腎capillary hemangiomaの1例

白石明日香, 松井裕輔, 宗友一晃, 平木隆夫, 生口俊浩, 冨田晃司, 宇賀麻由, 馬越紀行, 小牧稔幸, 金澤右

Japanese Journal of Radiology 40 ( Suppl. ) 44 - 44 2022.2

腎腫瘍生検後の出血に対し腎動脈塞栓術を施行した1例

宗友一晃, 生口俊浩, 郷原英夫, 松井裕輔, 冨田晃司, 宇賀麻由, 馬越紀行, 小牧稔幸, 平木隆夫, 金澤右

Japanese Journal of Radiology 40 ( Suppl. ) 44 - 44 2022.2

骨盤内動静脈奇形に対し経静脈的アプローチにて塞栓術を施行した2例

櫻井淳暢, 宇賀麻由, 松井裕輔, 宗友一晃, 生口俊浩, 小牧稔幸, 馬越紀行, 富田晃司, 櫻井淳, 郷原英夫, 平木隆夫

Japanese Journal of Radiology 40 ( Suppl. ) 51 - 51 2022.2

マルチモダリティロードマップを用いて経頸静脈的肝内門脈大循環短期術(TIPS)を行った1例

白石明日香, 冨田晃司, 宗友一晃, 平木隆夫, 生口俊浩, 松井裕輔, 宇賀麻由, 馬越紀行, 小牧稔幸, 金澤右

Japanese Journal of Radiology 40 ( Suppl. ) 50 - 50 2022.2

胆管チューブステントを経皮的に体外抜去した1例

河村俊一, 馬越紀行, 松井裕輔, 宗友一晃, 小牧稔幸, 宇賀麻由, 冨田晃司, 櫻井淳, 生口俊浩, 郷原英夫, 平木隆夫

Japanese Journal of Radiology 40 ( Suppl. ) 50 - 50 2022.2

上大静脈症候群に対するコスモテックステント留置の1例

馬越紀行, 冨田晃司, 平木隆夫, 生口俊浩, 松井裕輔, 宇賀麻由, 小牧稔幸, 宗友一晃, 郷原英夫, 金澤右

Japanese Journal of Radiology 40 ( Suppl. ) 45 - 45 2022.2

Pneumodissection during percutaneous renal cryoablation resulting in massive subcutaneous and mediastinal emphysema

Koji Tomita, Toshihiro Iguchi, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Takao Hiraki

Diagnostic and Interventional Imaging 103 ( 4 ) 231 - 232 2022.1

Massive hemoptysis in a post-operative patient with recurrent lung cancer successfully treated by the combination therapy of Endobronchial Watanabe Spigot and bronchial artery embolization

Masataka Taoka, Go Makimoto, Noriyuki Umakoshi, Kiichiro Ninomiya, Hisao Higo, Yuka Kato, Masanori Fujii, Toshio Kubo, Eiki Ichihara, Kadoaki Ohashi, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura

Respiratory Medicine Case Reports 38 101669 - 101669 2022

A single-center, single-arm, prospective, open-label trial to evaluate the efficacy and safety of percutaneous sclerotherapy with polidocanol for painful venous malformations (SCIRO-2001): study protocol Reviewed

Mayu Uka, Jun Sakurai, Yusuke Matsui, Toshihiro Iguchi, Koji Tomita, Noriyuki Umakoshi, Kazuaki Munetomo, Toshiharu Mitsuhashi, Hideo Gobara, Takao Hiraki

Nagoya J. Med. Sci. 84. 746–751, 2022 2021.12

Computed Tomography-guided Core Needle Biopsy for Renal Tumors: A Review

Toshihiro Iguchi, Yusuke Matsui, Koji Tomita, Mayu Uka, Toshiyuki Komaki, Soichiro Kajita, Noriyuki Umakoshi, Kazuaki Munetomo, Hideo Gobara, Susumu Kanazawa

Interventional Radiology 6 ( 3 ) 69 - 74 2021.11

Contrast examination of central venous access port implanted through internal jugular vein for evaluation of suspected complications.

Toshihiro Iguchi, Takao Hiraki, Yusuke Matsui, Koji Tomita, Mayu Uka, Noriyuki Umakoshi, Soichiro Kajita, Toshiyuki Komaki, Hideo Gobara, Susumu Kanazawa

Japanese journal of radiology 39 ( 11 ) 1103 - 1110 2021.11

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: We summarized the findings, diagnosis, and outcomes of cases for which contrast examination of central venous access ports (CV-ports) were attempted to detect complications. MATERIALS AND METHODS: Fifty-seven contrast examinations were attempted for 45 patients with 46 CV-ports (median, 162 days after implantation). Contrast examination was performed due to three suspicion catheter fractures or 54 CV-port dysfunctions (combinations of an absence of blood reflux on aspiration and 9 sufficient, 21 insufficient, or 24 impossible drip infusions). RESULTS: Contrast examination was successfully performed in 52 cases and revealed 45 normal findings, 5 pericatheter fibrin sheath formations, and 2 partial catheter fractures. In 23 of 45 cases with normal findings, the resistance to injection was initially mild or moderate but resolved after the CV-port was flushed slowly with heparinized saline solution. Subsequent contrast examination demonstrated normal findings. All fibrin sheath formations disappeared after thrombolytic therapy. Five cases could not undergo contrast examination due to high resistance. After contrast examination, nine of 46 CV-ports were removed or exchanged, while the use of the remaining 37 continued. CONCLUSION: Contrast examination of CV-port allowed the assessment of suspected complications and early treatment.

DOI： 10.1007/s11604-021-01142-4

胸膜に接する肺結節に対するCT透視ガイド下生検の穿刺経路の比較(CT fluoroscopy-guided biopsy for lung nodules with pleural contact: Comparison with puncture routes)

生口俊浩, 平木隆夫, 松井裕輔, 冨田晃司, 宇賀麻由, 馬越紀行, 梶田聡一郎, 小牧稔幸, 宗友一晃, 郷原英夫, 金澤右

日本インターベンショナルラジオロジー学会雑誌 36 ( Suppl. ) 149 - 149 2021.4

当院におけるT3a腎癌に対する経皮的凍結療法成績の検討(Percutaneous cryoablation outcome for clinical T3a renal cell carcinoma at our institution)

宇賀麻由, 大川七子, 宗友一晃, 馬越紀行, 小牧稔幸, 梶田聡一郎, 冨田晃司, 松井裕輔, 櫻井淳, 生口俊浩, 郷原英夫, 平木隆夫, 金澤右

日本インターベンショナルラジオロジー学会雑誌 36 ( Suppl. ) 182 - 182 2021.4

皮膚直下のタイプII動静脈奇形に対してポリドカノールフォームを用いて硬化療法を施行した一例

松井裕輔, 宇賀麻由, 平木隆夫, 生口俊浩, 冨田晃司, 馬越紀行, 小牧稔幸, 宗友一晃, 金澤右

日本インターベンショナルラジオロジー学会雑誌 36 ( Suppl. ) 242 - 242 2021.4

Diagnostic Value of Model-Based Iterative Reconstruction Combined with a Metal Artifact Reduction Algorithm during CT of the Oral Cavity. Reviewed International journal

Y Kubo, K Ito, M Sone, H Nagasawa, Y Onishi, N Umakoshi, T Hasegawa, T Akimoto, M Kusumoto

AJNR. American journal of neuroradiology 41 ( 11 ) 2132 - 2138 2020.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND PURPOSE: Metal artifacts reduce the quality of CT images and increase the difficulty of interpretation. This study compared the ability of model-based iterative reconstruction and hybrid iterative reconstruction to improve CT image quality in patients with metallic dental artifacts when both techniques were combined with a metal artifact reduction algorithm. MATERIALS AND METHODS: This retrospective clinical study included 40 patients (men, 31; women, 9; mean age, 62.9 ± 12.3 years) with oral and oropharyngeal cancer who had metallic dental fillings or implants and underwent contrast-enhanced ultra-high-resolution CT of the neck. Axial CT images were reconstructed using hybrid iterative reconstruction and model-based iterative reconstruction, and the metal artifact reduction algorithm was applied to all images. Finally, hybrid iterative reconstruction + metal artifact reduction algorithms and model-based iterative reconstruction + metal artifact reduction algorithm data were obtained. In the quantitative analysis, SDs were measured in ROIs over the apex of the tongue (metal artifacts) and nuchal muscle (no metal artifacts) and were used to calculate the metal artifact indexes. In a qualitative analysis, 3 radiologists blinded to the patients' conditions assessed the image-quality scores of metal artifact reduction and structural depictions. RESULTS: Hybrid iterative reconstruction + metal artifact reduction algorithms and model-based iterative reconstruction + metal artifact reduction algorithms yielded significantly different metal artifact indexes of 82.2 and 73.6, respectively (95% CI, 2.6-14.7; P < .01). The latter algorithms resulted in significant reduction in metal artifacts and significantly improved structural depictions(P < .01). CONCLUSIONS: Model-based iterative reconstruction + metal artifact reduction algorithms significantly reduced the artifacts and improved the image quality of structural depictions on neck CT images.

DOI： 10.3174/ajnr.A6767

Transhepatic Placement of Metallic Biliary Stent for Internal Drainage of Persistent Liver Abscesses. International journal

Noriyuki Umakoshi, Yasuaki Arai, Yoshitaka Inaba, Miyuki Sone, Shunsuke Sugawara, Chihiro Itoh, Tetsuya Hasegawa, Yasuyuki Onishi

Journal of vascular and interventional radiology : JVIR 31 ( 6 ) 1000 - 1004 2020.6

Language：English Publishing type：Research paper (scientific journal)

Transhepatic placement of a metallic biliary stent for internal drainage of persistent liver abscesses was performed in 9 patients (males; median age, 65 years; range, 57-82 years) with refractory liver abscess. The median follow-up period was 2.8 months (range, 0.4-50.3 months). Technical success was achieved in all cases without any major complications. Clinical success, defined as the removal of the drainage tube without recurrent symptoms of infection, was achieved in 8 cases. Median duration until removal of the drainage tube from stent placement was 7 days (range, 0-36).

DOI： 10.1016/j.jvir.2020.01.002

Compact coil packing using a steerable microcatheter for a giant wide-necked pulmonary artery pseudoaneurysm. International journal

Noriyuki Umakoshi, Yasuaki Arai, Miyuki Sone, Shunsuke Sugawara

Interactive cardiovascular and thoracic surgery 28 ( 5 ) 826 - 827 2019.5

Language：English Publishing type：Research paper (scientific journal)

A 74-year-old man developed a giant wide-necked pulmonary artery pseudoaneurysm. To prevent life-threatening haemoptysis, we performed percutaneous transcatheter coil embolization for the pulmonary artery pseudoaneurysm. To effectively isolate the pseudoaneurysm with the minimal number of coils, we used a steering microcatheter. With intentional folding using the bendable tip of the steerable microcatheter, we achieved compact coil packing for the target vessels, thus avoiding coil deviations and non-target embolization.

DOI： 10.1093/icvts/ivy332

Feasibility of genomic profiling with next-generation sequencing using specimens obtained by image-guided percutaneous needle biopsy. International journal

Miyuki Sone, Yasuaki Arai, Shunsuke Sugawara, Takatoshi Kubo, Chihiro Itou, Tetsuya Hasegawa, Noriyuki Umakoshi, Noboru Yamamoto, Kumiko Sunami, Nobuyoshi Hiraoka, Takashi Kubo

Upsala journal of medical sciences 124 ( 2 ) 119 - 124 2019.4

Language：English Publishing type：Research paper (scientific journal)

Aims: The demand for specimen collection for genomic profiling is rapidly increasing in the era of personalized medicine. Percutaneous needle biopsy is recognized as minimally invasive, but the feasibility of comprehensive genomic analysis using next-generation sequencing (NGS) is not yet clear. The purpose of this study was to evaluate the feasibility of genomic analysis using NGS with specimens obtained by image-guided percutaneous needle biopsy with 18-G needles. Patients and methods: Forty-eight patients who participated in a clinical study of genomic profiling with NGS with the specimen obtained by image-guided needle biopsy were included. All biopsies were performed under local anesthesia, with imaging guidance, using an 18-G cutting needle. A retrospective chart review was performed to determine the rate of successful genomic analysis, technical success rate of biopsy procedure, adverse events, rate of success in pathological diagnosis, and cause of failed genomic analysis. Results: The success rate of genomic analysis was 79.2% (38/48). The causes of failure were unprocessed for DNA extraction due to insufficient specimen volume (6/10), insufficient DNA volume (2/10), and deteriorated DNA quality (2/10). The rate of successful genomic analysis excluding NGS analysis that failed for reasons unrelated to the biopsy procedures was 95.2% (40/42). Technical success of biopsy was achieved in all patients without severe adverse events. The rate of success in the pathological diagnosis was 97.9% (47/48). Conclusions: Image-guided needle biopsy specimens using an 18-G cutting needle yielded a successful NGS genomic analysis rate with no severe adverse events and could be an adoptable method for tissue sampling for NGS.

DOI： 10.1080/03009734.2019.1607635

A Novel Technique of Urine Drainage from Bilateral Kidneys with a Single Catheter. International journal

Yasuyuki Onishi, Yasuaki Arai, Miyuki Sone, Chihiro Ito, Noriyuki Umakoshi, Shinji Wada

Journal of vascular and interventional radiology : JVIR 30 ( 3 ) 412 - 413 2019.3

A Case of Solitary Metastasis from a Hepatocellular Carcinoma to the Sacral Bone Successfully Treated with Percutaneous Cryoablation Reviewed

Noriyuki Umakoshi, Hideo Gobara, Takao Hiraki, Toshihiro Iguchi, Hiroyasu Fujiwara, Jun Sakurai, Yusuke Matsui, Yoshihisa Masaoka, Hiroki Ihara, Toshiaki Wada, Tomonori Seno, Susumu Kanazawa

Interventional Radiology 2 ( 1 ) 14 - 18 2017

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