Life Science / Pathological biochemistry

Assistant Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

2004 - 2012

postdoctoral fellow,Cleveland Clinic Foundation Lerner Research Institute

1997 - 2000

クリーブランドクリニック ラーナー研究所 博士研究員

1997 - 2000

日本内科学会

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Efficacy of an Adjunctive Electrophysiological Test-Guided Left Atrial Posterior Wall Isolation in Persistent Atrial Fibrillation Without a Left Atrial Low-Voltage Area. Reviewed International journal

Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Kazuyoshi Hina, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

Circulation. Arrhythmia and electrophysiology   13 ( 8 )   e008191   2020.8

Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. Reviewed International journal

Takashi Ohtsuki, Omer F Hatipoglu, Keiichi Asano, Junko Inagaki, Keiichiro Nishida, Satoshi Hirohata

International journal of molecular sciences   21 ( 9 )   2020.4

Deficiency of CD44 prevents thoracic aortic dissection in a murine model. Reviewed International journal

Omer F Hatipoglu, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Naofumi Amioka, Masashi Yoshida, Satoshi Akagi, Kazufumi Nakamura, Satoshi Hirohata, Hiroshi Ito

Scientific reports   10 ( 1 )   6869 - 6869   2020.4

Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. Reviewed International journal

Takashi Ohtsuki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Keiichi Asano, Omer Faruk Hatipoglu, Junko Inagaki, Ken Takahashi, Toshitaka Oohashi, Keiichiro Nishida, Keiji Naruse, Satoshi Hirohata

Experimental cell research   383 ( 2 )   111556 - 111556   2019.10

Serum malondialdehyde-modified low-density lipoprotein levels on admission predict prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention Reviewed International journal

Naofumi Amioka, Toru Miyoshi, Hiroaki Otsuka, Daisuke Yamada, Atsushi Takaishi, Masayuki Ueeda, Satoshi Hirohata, Hiroshi Ito

JOURNAL OF CARDIOLOGY   74 ( 3-4 )   258 - 266   2019.9

High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression. Reviewed International journal

Takashi Ohtsuki, Keiichi Asano, Junko Inagaki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Mehmet Z Cilek, Omer F Hatipoglu, Toshitaka Oohashi, Keiichiro Nishida, Issei Komatsubara, Satoshi Hirohata

Journal of orthopaedic research : official publication of the Orthopaedic Research Society   36 ( 12 )   3247 - 3255   2018.12

Non-alcoholic steatohepatitis aggravates nitric oxide synthase inhibition-induced arteriosclerosis in SHRSP5/Dmcr rat model Reviewed International journal

Shogo Watanabe, Shota Kumazaki, Shusei Yamamoto, Ikumi Sato, Kazuya Kitamori, Mari Mori, Yukio Yamori, Satoshi Hirohata

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY   99 ( 6 )   282 - 294   2018.12

Differences in activated clotting time and initial heparin dosage during atrial fibrillation ablation for patients with edoxaban compared with warfarin Reviewed International journal

Hirosuke Yamaji, Takashi Murakami, Kazuyoshi Hina, Shunichi Higashiya, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

Journal of Cardiovascular Electrophysiology   29 ( 6 )   835 - 843   2018.6

Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth. Reviewed

Keiichi Asano, Midori Edamatsu, Omer F Hatipoglu, Junko Inagaki, Mitsuaki Ono, Takashi Ohtsuki, Toshitaka Oohashi, Satoshi Hirohata

Acta medica Okayama   72 ( 3 )   257 - 266   2018.6

A high-fat and high-cholesterol diet induces cardiac fibrosis, vascular endothelial, and left ventricular diastolic dysfunction in shrsp5/dmcr rats Reviewed

Shogo Watanabe, Shota Kumazaki, Katsuhiro Kusunoki, Terumi Inoue, Yui Maeda, Shinichi Usui, Ryoko Shinohata, Takashi Ohtsuki, Satoshi Hirohata, Shozo Kusachi, Kazuya Kitamori, Mari Mori, Yukio Yamori, Hisao Oka

Journal of Atherosclerosis and Thrombosis   25 ( 5 )   439 - 453   2018

Stromal Versican Regulates Tumor Growth by Promoting Angiogenesis Reviewed International journal

Keiichi Asano, Courtney M. Nelson, Sumeda Nandadasa, Noriko Aramaki-Hattori, Daniel J. Lindner, Tyler Alban, Junko Inagaki, Takashi Ohtsuki, Toshitaka Oohashi, Suneel S. Apte, Satoshi Hirohata

SCIENTIFIC REPORTS   7 ( 1 )   2101 - 2105   2017.12

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1 Reviewed International journal

Kazuhiro Yamamoto, Hiroshi Okano, Wakako Miyagawa, Robert Visse, Yasuyuki Shitomi, Salvatore Santamaria, Jayesh Dudhia, Linda Troeberg, Dudley K. Strickland, Satoshi Hirohata, Hideaki Nagase

MATRIX BIOLOGY   56   57 - 73   2016.12

Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice Reviewed International journal

Saran Kumar, Mo Chen, Yan Li, Fiona H. S. Wong, Chung Wee Thiam, Md Zakir Hossain, Kian Keong Poh, Satoshi Hirohata, Hiroko Ogawa, Veronique Angeli, Ruowen Ge

SCIENTIFIC REPORTS   6   31130 - 31130   2016.8

Interleukin-1 induced nuclear factor-B binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells Reviewed International journal

Aynur Altuntas, Sevil Oskay Halacli, Ozlem Cakmak, Gonul Erden, Sumeyya Akyol, Veli Ugurcu, Satoshi Hirohata, Kadir Demircan

MOLECULAR MEDICINE REPORTS   12 ( 1 )   595 - 600   2015.7

ADAMTS1 inhibits lymphangiogenesis by attenuating phosphorylation of the lymphatic endothelial cell-specific VEGF receptor. Reviewed International journal

Junko Inagaki, Katsuyuki Takahashi, Hiroko Ogawa, Keiichi Asano, Omer Faruk Hatipoglu, Mehmet Zeynel Cilek, Masanari Obika, Takashi Ohtsuki, Matthias Hofmann, Shozo Kusachi, Yoshifumi Ninomiya, Satoshi Hirohata

Experimental cell research   323 ( 2 )   263 - 75   2014.5

ADAMTS4 and ADAMTS5 Knockout Mice Are Protected from Versican but Not Aggrecan or Brevican Proteolysis during Spinal Cord Injury International journal

Kadir Demircan, Vehap Topcu, Tomoyuki Takigawa, Sumeyya Akyol, Tomoko Yonezawa, Gulfer Ozturk, Veli Ugurcu, Rukiye Hasgul, M. Ramazan Yigitoglu, Omer Akyol, Daniel R. McCulloch, Satoshi Hirohata

BIOMED RESEARCH INTERNATIONAL   2014 ( 2014 )   693746 - 693746   2014

Augmentation of ADAMTS9 gene expression by IL-1 beta is reversed by NF kappa B and MAPK inhibitors, but not PI3 kinase inhibitors Reviewed International journal

Sema Uysal, Zahide Nur Unal, Serpil Erdogan, Sumeyya Akyol, M. Ramazan Yigitoglu, Satoshi Hirohata, Bunyamin Isik, Kadir Demircan

CELL BIOCHEMISTRY AND FUNCTION   31 ( 7 )   539 - 544   2013.10

Vascular endothelial growth factor C-induced lymphangiogenesis decreases tumor interstitial fluid pressure and tumor. Reviewed International journal

Matthias Hofmann, Ralph Pflanzer, Nadja Nicole Zoller, August Bernd, Roland Kaufmann, Diamant Thaci, Jurgen Bereiter-Hahn, Satoshi Hirohata, Stefan Kippenberger

Translational oncology   6 ( 4 )   398 - 404   2013.8

ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse Reviewed International journal

Kadir Demircan, Tomoko Yonezawa, Tomoyuki Takigawa, Vehap Topcu, Serpil Erdogan, Fatma Ucar, Ferah Armutcu, M. Ramazan Yigitoglu, Yoshifumi Ninomiya, Satoshi Hirohata

NEUROSCIENCE LETTERS   544   25 - 30   2013.6

Eosinophil cationic protein enhances stabilization of beta-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells Reviewed International journal

Guoliang Jin, Akifumi Mizutani, Takayuki Fukuda, Takayuki Otani, Ting Yan, Marta Prieto Vila, Hiroshi Murakami, Takayuki Kudoh, Satoshi Hirohata, Tomonari Kasai, David S. Salomon, Masaharu Seno

MOLECULAR BIOLOGY REPORTS   40 ( 4 )   3165 - 3171   2013.4

Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis. Reviewed International journal

Masanari Obika, Hiroko Ogawa, Katsuyuki Takahashi, Jiayi Li, Omer Faruk Hatipoglu, Mehmet Zeynel Cilek, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Shozo Kusachi, Yoshifumi Ninomiya, Satoshi Hirohata

Cancer science   103 ( 10 )   1889 - 97   2012.10

Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway Reviewed International journal

Guoliang Jin, Akifumi Mizutani, Takayuki Fukuda, Ling Chen, Keisuke Nakanishi, Ting Yan, Takayuki Kudoh, Satoshi Hirohata, Tomonari Kasai, Hiroshi Murakami, David S. Salomon, Masaharu Seno

GROWTH FACTORS   30 ( 5 )   344 - 355   2012.10

Four-year clinical outcomes of the OLIVUS-Ex (impact of Olmesartan on progression of coronary atherosclerosis: Evaluation by intravascular ultrasound) extension trial Reviewed International journal

Atsushi Hirohata, Keizo Yamamoto, Toru Miyoshi, Kunihiko Hatanaka, Satoshi Hirohata, Hitoshi Yamawaki, Issei Komatsubara, Eiki Hirose, Yuhei Kobayashi, Keisuke Ohkawa, Minako Ohara, Hiroya Takafuji, Fumihiko Sano, Yuko Toyama, Shozo Kusachi, Tohru Ohe, Hiroshi Ito

ATHEROSCLEROSIS   220 ( 1 )   134 - 138   2012.1

Association of increased plasma adipocyte fatty acid-binding protein with coronary artery disease in non-elderly men Reviewed International journal

Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Kazufumi Nakamura, Shinichi Usui, Ko Takeda, Mutsumi Iwamoto, Shozo Kusachi, Kengo Kusano, Hiroshi Ito

CARDIOVASCULAR DIABETOLOGY   10   44 - 44   2011.5

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells Reviewed

T. Tetsunaga, K. Nishida, T. Furumatsu, K. Naruse, S. Hirohata, A. Yoshida, T. Saito, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE   19 ( 2 )   222 - 232   2011.2

AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo. Reviewed International journal

Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Hiroko Ogawa, Toru Miyoshi, Junko Inagaki, Takashi Ohtsuki, Hiroshi Harada, Shigeshi Kamikawa, Shozo Kusachi, Yoshifumi Ninomiya

Cell biology international   35 ( 1 )   1 - 8   2011.1

Connective tissue growth factor induction in a pressure-overloaded heart ameliorated by the angiotensin II type 1 receptor blocker olmesartan Reviewed International journal

Mutsumi Iwamoto, Satoshi Hirohata, Hiroko Ogawa, Takashi Ohtsuki, Ryoko Shinohata, Toru Miyoshi, O. Faruk Hatipoglu, Shozo Kusachi, Kazuhide Yamamoto, Yoshifumi Ninomiya

HYPERTENSION RESEARCH   33 ( 12 )   1305 - 1311   2010.12

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis Reviewed International journal

Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya, Hirofumi Makino

Arthritis Research and Therapy   12 ( 4 )   R133   2010.7

Serum adipocyte fatty acid-binding protein is independently associated with coronary atherosclerotic burden measured by intravascular ultrasound Reviewed International journal

Toru Miyoshi, Go Onoue, Atsushi Hirohata, Satoshi Hirohata, Shinichi Usui, Kazuyoshi Hina, Hiroshi Kawamura, Masayuki Doi, Kengo Fukushima Kusano, Shozo Kusachi, Yoshifumi Ninomiya

ATHEROSCLEROSIS   211 ( 1 )   164 - 169   2010.7

Type IV Collagen Induces Expression of Thrombospondin-1 that is Mediated by Integrin alpha 1 beta 1 in Astrocytes Reviewed International journal

Tomoko Yonezawa, Shunji Hattori, Junko Inagaki, Masae Kurosaki, Tomoyuki Takigawa, Satoshi Hirohata, Toru Miyoshi, Yoshifumi Ninomiyai

GLIA   58 ( 7 )   755 - 767   2010.5

Impact of Olmesartan on Progression of Coronary Atherosclerosis A Serial Volumetric Intravascular Ultrasound Analysis From the OLIVUS (Impact of OLmesarten on progression of coronary atherosclerosis: evaluation by IntraVascular UltraSound) Trial Reviewed International journal

Atsushi Hirohata, Keizo Yamamoto, Toru Miyoshi, Kunihiko Hatanaka, Satoshi Hirohata, Hitoshi Yamawaki, Issei Komatsubara, Masaaki Murakami, Eiki Hirose, Shinji Sato, Keisuke Ohkawa, Makoto Ishizawa, Hirosuke Yamaji, Hiroshi Kawamura, Shozo Kusachi, Takashi Murakami, Kazuyoshi Hina, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   55 ( 10 )   976 - 982   2010.3

Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis Reviewed

K. Ayada, K. Yokota, K. Hirai, K. Fujimoto, K. Kobayashi, H. Ogawa, K. Hatanaka, S. Hirohata, T. Yoshino, Y. Shoenfeld, E. Matsuura, K. Oguma

LUPUS   18 ( 13 )   1154 - 1168   2009.11

INCREASED mRNA EXPRESSION OF ADAMTS METALLOPROTEINASES IN METASTATIC FOCI OF HEAD AND NECK CANCER Reviewed International journal

Kadir Demircan, Esra Gunduz, Mehmet Gunduz, Levent Bekir Beder, Satoshi Hirohata, Hitoshi Nagatsuka, Beyhan Cengiz, Mehmet Zeynel Cilek, Noboru Yamanaka, Kenji Shimizu, Yoshifumi Ninomiya

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK   31 ( 6 )   793 - 801   2009.6

ADAMTS1 Is a Unique Hypoxic Early Response Gene Expressed by Endothelial Cells Reviewed International journal

Omer F. Hatipoglu, Satoshi Hirohata, M. Zeynel Cilek, Hiroko Ogawa, Toru Miyoshi, Masanari Obika, Kadir Demircan, Ryoko Shinohata, Shozo Kusachi, Yoshifumi Ninomiya

JOURNAL OF BIOLOGICAL CHEMISTRY   284 ( 24 )   16325 - 16333   2009.6

The 3'-untranslated region of ADAMTS1 regulates its mRNA stability. Reviewed

Omer Faruk Hatipoglu, Satoshi Hirohata, Kursat Oguz Yaykasli, Mehmet Zeynel Cilek, Kadir Demircan, Ryoko Shinohata, Tomoko Yonezawa, Toshitaka Oohashi, Shozo Kusachi, Yoshifumi Ninomiya

Acta medica Okayama   63 ( 2 )   79 - 85   2009.4

ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. Reviewed International journal

Kursat Oguz Yaykasli, Toshitaka Oohashi, Satoshi Hirohata, Omer Faruk Hatipoglu, Kiichi Inagawa, Kadir Demircan, Yoshifumi Ninomiya

Molecular and cellular biochemistry   323 ( 1-2 )   69 - 79   2009.3

siRNA silencing reveals role of vascular cell adhesion molecule-1 in vascular smooth muscle cell migration Reviewed International journal

Erik J. Petersen, Toru Miyoshi, Zuobiao Yuan, Satoshi Hirohata, Jin Zhong Li, Weibin Shi, John F. Angle

ATHEROSCLEROSIS   198 ( 2 )   301 - 306   2008.6

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen anti body-induced arthritis mouse model Reviewed

Y. Nasu, K. Nishida, S. Miyazawa, T. Komiyama, Y. Kadota, N. Abe, A. Yoshida, S. Hirohata, A. Ohtsuka, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE   16 ( 6 )   723 - 732   2008.6

Association of augmentation index of radial pressure wave form with diurnal variation pattern of blood pressure in untreated patients with essential hypertension Reviewed International journal

Ryoko Shinohata, Takaaki Nakatsu, Yoko Yuki, Aya Nishitani, Keiichi Mashima, Shinji Toyonaga, Hiroko Ogawa, Satoshi Hirohata, Shinichi Usui, Tomoki Kitawaki, Shozo Kusachi

JOURNAL OF HYPERTENSION   26 ( 3 )   535 - 543   2008.3

Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients, and negatively correlated with infarct size Reviewed International journal

Kazuya Koten, Satoshi Hirohata, Toru Miyoshi, Hiroko Ogawa, Shinichi Usui, Ryoko Shinohata, Mutsumi Iwamoto, Tomoki Kitawaki, Shozo Kusachi, Kosaku Sakaguchi, Tohru Ohe

CLINICAL BIOCHEMISTRY   41 ( 1-2 )   30 - 37   2008.1

Antibodies against heat shock protein 60 derived from Helicobacter pylori: Diagnostic implications in cardiovascular disease Reviewed

Tomoyuki Okada, Kiyoshi Ayada, Shinichi Usui, Kenji Yokata, Jinhua Cui, Yoshiro Kawahara, Tomoki Inaba, Satoshi Hirohata, Motowo Mizuno, Daisuke Yamamoto, Shozo Kusachi, Eiji Matsuura, Keiji Oguma

JOURNAL OF AUTOIMMUNITY   29 ( 2-3 )   106 - 115   2007.9

Use of plasma B-Type natriuretic peptide level to identify asymptomatic hypertensive patients with abnormal diurnal blood pressure variation profiles: nondippers, extreme dippers, and risers Reviewed International journal

Takaaki Nakatsu, Ryoko Shinohata, Keiichi Mashima, Yoko Yuki, Aya Nishitani, Shinji Toyonaga, Hiroko Ogawa, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi

HYPERTENSION RESEARCH   30 ( 7 )   651 - 658   2007.7

Thrombospondin-1 is induced in rat myocardial infarction and its induction is accelerated by ischemia/reperfusion Reviewed International journal

S Sezaki, S Hirohata, A Iwabu, K Nakamura, K Toeda, T Miyoshi, H Yamawaki, K Demircan, S Kusachi, Y Shiratori, Y Ninomiya

EXPERIMENTAL BIOLOGY AND MEDICINE   230 ( 9 )   621 - 630   2005.10

Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status Reviewed International journal

H Ito, T Kanzawa, T Miyoshi, S Hirohata, S Kyo, A Iwamaru, H Aoki, Y Kondo, S Kondo

HUMAN GENE THERAPY   16 ( 6 )   685 - 698   2005.6

ADAMTS-9 is synergistically induced by interleukin-1 beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes Reviewed International journal

K Demircan, S Hirohata, K Nishida, OF Hatipoglu, T Oohashi, T Yonezawa, SS Apte, Y Ninomiya

ARTHRITIS AND RHEUMATISM   52 ( 5 )   1451 - 1460   2005.5

Suppression of chondrosarcoma cells by 15-deoxy-Delta (12,14)-prostaglandin J(2) is associated with altered expression of Bax/Bcl-xL and p21 Reviewed International journal

ZN Shen, K Nishida, H Doi, T Oohashi, S Hirohata, T Ozaki, A Yoshida, Y Ninomiya, H Inoue

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   328 ( 2 )   375 - 382   2005.3

Time-dependent changes in plasma osteopontin levels in patients with anterior-wall acute myocardial infarction after successful reperfusion: Correlation with left-ventricular volume and function International journal

C Suezawa, S Kusachi, T Murakami, K Toeda, S Hirohata, K Nakamura, K Yamamoto, K Koten, T Miyoshi, Y Shiratori

JOURNAL OF LABORATORY AND CLINICAL MEDICINE   145 ( 1 )   33 - 40   2005.1

Lp3/Hapln3, a novel link protein that co-localizes with versican and is coordinately up-regulated by platelet-derived growth factor in arterial smooth muscle cells International journal

H Ogawa, T Oohashi, M Sata, Y Bekku, S Hirohataa, K Nakamura, T Yonezawa, S Kusachi, Y Shiratori, Y Ninomiya

MATRIX BIOLOGY   23 ( 5 )   287 - 298   2004.8

Increased expression of dermatopontin mRNA in the infarct zone of experimentally induced myocardial infarction in rats: comparison with decorin and type I collagen mRNAs International journal

S Takemoto, T Murakami, S Kusachi, A Iwabu, S Hirohata, K Nakamura, S Sezaki, J Hayashi, C Suezawa, Y Ninomiya, T Tsuji

BASIC RESEARCH IN CARDIOLOGY   97 ( 6 )   461 - 468   2002.11

Caspase-8 gene therapy using the human telomerase reverse transcriptase promoter for malignant glioma cells International journal

T Komata, Y Kondo, T Kanzawa, H Ito, S Hirohata, S Koga, H Sumiyoshi, M Takakura, M Inoue, BP Barna, EM Germano, S Kyo, S Kondo

HUMAN GENE THERAPY   13 ( 9 )   1015 - 1025   2002.6

Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix International journal

S Hirohata, LW Wang, M Miyagi, L Yan, MF Seldin, DR Keene, JW Crabb, SS Apte

JOURNAL OF BIOLOGICAL CHEMISTRY   277 ( 14 )   12182 - 12189   2002.4

Procollagen II amino propeptide processing by ADAMTS-3 - Insights on dermatosparaxis

RJ Fernandes, S Hirohata, JM Engle, A Colige, DH Cohn, DR Eyre, SS Apte

JOURNAL OF BIOLOGICAL CHEMISTRY   276 ( 34 )   31502 - 31509   2001.8

Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter

T Komata, Y Kondo, T Kanzawa, S Hirohata, S Koga, H Sumiyoshi, SM Srinivasula, BP Barna, IM Germano, M Takakura, M Inoue, ES Alnemri, JW Shay, S Kyo, S Kondo

CANCER RESEARCH   61 ( 15 )   5796 - 5802   2001.8

FADD gene therapy using the human telomerase catalytic subunit (hTERT) gene promoter to restrict induction of apoptosis to tumors in vitro and in vivo

S Koga, S Hirohata, Y Kondo, T Komata, M Takakura, M Inoue, S Kyo, S Kondo

ANTICANCER RESEARCH   21 ( 3B )   1937 - 1943   2001.5

ADAMTS family - New extracellular matrix degrading enzyme

S. Hirohata

Seikagaku   73 ( 11 )   1333 - 1337   2001

A novel telomerase-specific gene therapy: Gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter

Shoji Koga, Satoshi Hirohata, Yasuko Kondo, Tadashi Komata, Masahiro Takakura, Masaki Inoue, Saturo Kyo, Seiji Kondo

Human Gene Therapy   11 ( 10 )   1397 - 1406   2000.7

Chromosomal mapping of Adam9, Adam15 and Adam21

Michael F. Seldin, Satoshi Hirohata, Suneel S. Apte

Matrix Biology   May;19(2):185-7 ( 2 )   185 - 187   2000.5

ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse chromosome 9 and human chromosome 11

Katy E. Georgiadis, Satoshi Hirohata, Michael F. Seldin, Suneel S. Apte

Genomics   Dec 1;62(2):312-5 ( 2 )   312 - 315   1999.12

ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

Tuna L. Hurskainen, Satoshi Hirohata, Michael F. Seldin, Suneel S. Apte

Journal of Biological Chemistry   Sep 3;274(36):25555-63 ( 36 )   25555 - 25563   1999.9

Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively

Timothy M. Olson, Satoshi Hirohata, Jean Ye, Kevin Leco, Michael F. Seldin, Suneel S. Apte

Genomics   Jul 1;51(1):148-51 ( 1 )   148 - 151   1998.7

Time-dependent alterations of serum levels of triple-helix domain and 7S domain of type IV collagen in patients with acute myocardial infarction after successful reperfusion: Limited relation to left ventricular ejection fraction

Y Kajikawa, S Kusachi, J Kondo, Sano, I, K Yamamoto, S Hirohata, M Murakami, T Murakami, T Tsuji

CLINICA CHIMICA ACTA   258 ( 2 )   241 - 247   1997.2

Laminin α1, α2, α4 and β1 chain mRNA expression in mouse embryonic, neonatal, and adult hearts

Satoshi Hirohata, Shozo Kusachi, Jun Kondo, Issei Sano, Masahiro Murakami, Masayuki Doi, Yoshifumi Ninomiya, Takao Tsuji

Japanese Heart Journal   Mar;38(2):281-9 ( 2 )   281 - 289   1997

Time dependent alterations of serum matrix metalloproteinase-1 and metalloproteinase-1 tissue inhibitor after successful reperfusion of acute myocardial infarction

Satoshi Hirohata, Shozo Kusachi, Masahiro Murakami, Takashi Murakami, Issei Sano, Tomoko Watanabe, Issei Komatsubara, Jun Kondo, Takao Tsuji

Heart   78 ( 3 )   278 - 284   1997

Tenascin expression in endomyocardial biopsy specimens in patients with dilated cardiomyopathy: Distribution along margin of fibrotic lesions

Akiko Tamura, Shozo Kusachi, Kunio Nogami, Asami Yamanishi, Yutaka Kajikawa, Satoshi Hirohata, Takao Tsuji

Heart   75 ( 3 )   295 - 300   1996

Reperfusion hastens appearance and extent of distribution of type I collagen in infarct zone: Immunohistochemical study in rat experimental infarction

S. Yamasaki, S. Kusachi, H. Moritani, J. Kondo, S. Hirohata, A. Tamura, T. Tsuji

Cardiovascular Research   30 ( 5 )   763 - 768   1995

Coronary cross-sectional area stenosis severity determined using coronary CT highly correlated with coronary functional flow reserve: a pilot study. Reviewed International journal

Takuto Koumoto, Shozo Kusachi, Takumi Tomiya, Takuya Akagi, Hiroshi Kawamura, Satoshi Hirohata, Hirosuke Yamaji, Takashi Murakami, Shigeshi Kamikawa, Masaaki Murakami

Scientific reports   15 ( 1 )   26737 - 26737   2025.7

Efficacy and safety of a novel diamond tip temperature-controlled catheter for left atrial posterior wall isolation under electrogram guidance. Reviewed International journal

Hirosuke Yamaji, Souhei Kawafuji, Masaya Sano, Shunichi Higashiya, Motoki Kubo, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing   2025.6

Continuous Stimulation with Glycolaldehyde-derived Advanced Glycation End Product Reduces Aggrecan and COL2A1 Production via RAGE in Human OUMS-27 Chondrosarcoma Cells. Reviewed

Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hideo Takahashi, Hidenori Wake

Acta medica Okayama   79 ( 3 )   157 - 166   2025.6

Clinical Variables that Predict Liver-related Events in Steatotic Liver Disease Diagnosed by a Liver Biopsy. Reviewed

Shinnosuke Okubo, Akinobu Takaki, Ikumi Sato, Takuya Adachi, Yasuto Takeuchi, Masahiko Sue, Nozomi Miyake, Hideki Onishi, Satoshi Hirohata, Motoyuki Otsuka

Internal medicine (Tokyo, Japan)   2025.2

Activated Clotting Time Requires Adaptation Across Altered Measurement Devices: Determination of Appropriate Range During Atrial Fibrillation Ablation. Reviewed International journal

Haruna Sakanoue, Hirosuke Yamaji, Sayaka Okamoto, Kumi Okano, Yuka Fujita, Shunichi Higashiya, Takashi Murakami, Satoshi Hirohata, Shozo Kusachi

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis   31   10760296251332938 - 10760296251332938   2025

Histidine-rich glycoprotein inhibits TNF-α-induced tube formation in human vascular endothelial cells. Reviewed International journal

Omer Faruk Hatipoglu, Takashi Nishinaka, Kursat Oguz Yaykasli, Shuji Mori, Masahiro Watanabe, Takao Toyomura, Masahiro Nishibori, Satoshi Hirohata, Hidenori Wake, Hideo Takahashi

Frontiers in pharmacology   16   1561628 - 1561628   2025

Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes Reviewed

Takashi Ohtsuki, Ikumi Sato, Ren Takashita, Shintaro Kodama, Kentaro Ikemura, Gabriel Opoku, Shogo Watanabe, Takayuki Furumatsu, Hiroshi Yamada, Mitsuru Ando, Kazunari Akiyoshi, Keiichiro Nishida, Satoshi Hirohata

International Journal of Molecular Sciences   25 ( 22 )   11942   2024.11

Efficacy and safety of a novel temperature-controlled catheter for cavotricuspid isthmus ablation. Reviewed International journal

Masaya Sano, Hirosuke Yamaji, Shunichi Higashiya, Motoki Kubo, Takashi Murakami, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

Journal of cardiovascular electrophysiology   2024.7

Uric Acid Elevation by Fructose Overload Exacerbates Nash and Atherosclerosis via Oxidative Stress Reviewed

Moe Fujii, Mai Kakimoto, Ikumi Sato, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoshi Hirohata, Kazuya Kitamori, Shang Ran, Shusei Yamamoto, Shogo Watanabe

Current Nutrition and Food Science   20 ( 2 )   250 - 261   2024

Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model. Reviewed International journal

Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Satoru Tamura, Minoru Ueda, Satoshi Hirohata, Shogo Watanabe

Canadian journal of physiology and pharmacology   101 ( 9 )   455 - 465   2023.9

SHRSP5/Dmcr rats fed a high-fat and high-cholesterol diet develop disease-induced sarcopenia as nonalcoholic steatohepatitis progresses. Reviewed International journal

Shusei Yamamoto, Koki Honma, Moe Fujii, Mai Kakimoto, Sora Kirihara, Hinako Nakayama, Kazuya Kitamori, Ikumi Sato, Satoshi Hirohata, Shogo Watanabe

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft   249   152104 - 152104   2023.8

Evidence for Hypoxia-Induced Shift in ATP Production from Glycolysis to Mitochondrial Respiration in Pulmonary Artery Smooth Muscle Cells in Pulmonary Arterial Hypertension. Reviewed International journal

Satoshi Akagi, Kazufumi Nakamura, Megumi Kondo, Satoshi Hirohata, Heiichiro Udono, Mikako Nishida, Yukihiro Saito, Masashi Yoshida, Toru Miyoshi, Hiroshi Ito

Journal of clinical medicine   12 ( 15 )   2023.7

Selective autophagy associated with iron overload aggravates non-alcoholic steatohepatitis via ferroptosis. Reviewed International journal

Koki Honma, Sora Kirihara, Hinako Nakayama, Taketo Fukuoka, Toshiaki Ohara, Kazuya Kitamori, Ikumi Sato, Satoshi Hirohata, Moe Fujii, Shusei Yamamoto, Shang Ran, Shogo Watanabe

Experimental biology and medicine (Maywood, N.J.)   248 ( 13 )   1112 - 1123   2023.7

Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats. Reviewed International journal

Mai Kakimoto, Moe Fujii, Ikumi Sato, Koki Honma, Hinako Nakayama, Sora Kirihara, Taketo Fukuoka, Shang Ran, Satoshi Hirohata, Kazuya Kitamori, Shusei Yamamoto, Shogo Watanabe

Journal of applied biomedicine   21 ( 2 )   80 - 90   2023.6

高脂肪食誘導性NASH動物モデルにおける腸内細菌叢とLeaky gutの評価 Reviewed

桐原 空, 中山 日菜子, 福岡 威人, 本間 宏基, 藤井 萌, 廣畑 聡, 山元 修成, 渡辺 彰吾

腸内細菌学雑誌   37 ( 2 )   103 - 103   2023.4

ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711. Reviewed International journal

Masaya Matsuzaki, Miyabishara Yokoyama, Yota Yoshizawa, Naoki Kaneko, Hiroki Naito, Honoka Kobayashi, Akihito Korenaga, Sadanori Sekiya, Kentaro Ikemura, Gabriel Opoku, Satoshi Hirohata, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita

Molecular psychiatry   28 ( 4 )   1802 - 1812   2023.4

高脂肪食が腸内細菌叢および肝臓NLRP3インフラマソームに与える影響 Reviewed

中山 日菜子, 桐原 空, 福岡 威人, 本間 宏基, 藤井 萌, 廣畑 聡, 山元 修成, 渡辺 彰吾

腸内細菌学雑誌   37 ( 2 )   104 - 104   2023.4

Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat. Reviewed

Shusei Yamamoto, Ikumi Sato, Moe Fujii, Mai Kakimoto, Koki Honma, Natsumi Akiyama, Miku Sakai, Natsuki Fukuhama, Shota Kumazaki, Satoshi Hirohata, Kazuya Kitamori, Yukio Yamori, Shogo Watanabe

Acta medica Okayama   77 ( 1 )   29 - 36   2023.2

Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. Reviewed International journal

Mellissa C Alcantara, Kentaro Suzuki, Alvin R Acebedo, Daiki Kajioka, Satoshi Hirohata, Tsuneyasu Kaisho, Yu Hatano, Kazuo Yamagata, Satoru Takahashi, Gen Yamada

iScience   25 ( 12 )   105609 - 105609   2022.12

非アルコール性脂肪肝炎モデル動物であるSHRSP5/Dmcrラットは二次性サルコペニアを発症する

山元 修成, 本間 宏基, 藤井 萌, 柿本 麻衣, 桐原 空, 中山 日菜子, 佐藤 生弥, 廣畑 聡, 渡辺 彰吾

日本サルコペニア・フレイル学会雑誌   6 ( Suppl. )   180 - 180   2022.10

Basic characteristics between mechanomyogram and muscle force during twitch and tetanic contractions in rat skeletal muscles. Reviewed International journal

Ikumi Sato, Shusei Yamamoto, Mai Kakimoto, Moe Fujii, Koki Honma, Shota Kumazaki, Mami Matsui, Hinako Nakayama, Sora Kirihara, Shang Ran, Satoshi Hirohata, Shogo Watanabe

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology   62   102627 - 102627   2022.2

Plasma Arginase-1 Level Is Associated with the Mental Status of Outpatients with Chronic Liver Disease. Reviewed International journal

Noriyoshi Ogino, Fusao Ikeda, Shihoko Namba, Shinnosuke Ohkubo, Tomoaki Nishimura, Hiroyuki Okada, Satoshi Hirohata, Narufumi Suganuma, Keiki Ogino

Diagnostics (Basel, Switzerland)   11 ( 2 )   2021.2

Bile acids aggravate nonalcoholic steatohepatitis and cardiovascular disease in SHRSP5/Dmcr rat model. Reviewed International journal

Shusei Yamamoto, Ikumi Sato, Natsuki Fukuhama, Natsumi Akiyama, Miku Sakai, Shota Kumazaki, Shang Ran, Satoshi Hirohata, Kazuya Kitamori, Yukio Yamori, Shogo Watanabe

Experimental and molecular pathology   114   104437 - 104437   2020.6

Activated clotting time on the day of atrial fibrillation ablation for minimally interrupted and uninterrupted direct oral anticoagulation therapy: Sequential changes, differences among direct oral anticoagulants, and ablation safety outcomes Reviewed International journal

Hirosuke Yamaji, Takashi Murakami, Kazuyoshi Hina, Shunich Higashiya, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY   30 ( 12 )   2823 - 2833   2019.12

Effects of Oral Anticoagulants on Patients With Atrial Fibrillation Aged 90 Years and Older: Comparison Among Direct Oral Anticoagulant, Warfarin Anticoagulant, and Nonanticoagulation Reviewed International journal

Hirosuke Yamaji, Shunichi Higashiya, Takashi Murakami, Kazuyoshi Hina, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY   74 ( 3 )   246 - 254   2019.9

経皮的冠動脈インターベンション（PCI）支援ロボットの現状と将来展望

松浦龍太郎, 渡邊彰吾, 廣畑 聡

臨床画像   65 ( 4 )   480 - 485   2019.4

Bile Acid Metabolism is an Intermediary Factor between Non-Alcoholic Steatohepatitis and Ischemic Heart Disease in SHRSP5/Dmcr Rats

Shota Kumazaki, Mayu Nakamura, Shun Sasaki, Rina Tagashira, Nozomi Maruyama, Ikumi Sato, Shusei Yamamoto, Shang Ran, Shinichi Usui, Ryoko Shinohata, Takashi Ohtsuki, Satoshi Hirohata, Kazuya Kitamori, Mari Mori, Yukio Yamori, Shogo Watanabe

Journal of Nutrition & Food Sciences   09 ( 04 )   2019

Adjunctive left anterior line ablation induced left atrial dysfunction and dyssynchrony in atrial fibrillation ablation. Reviewed

Yamaji H, Murakami T, Hina K, Higashiya S, Kawamura H, Murakami M, Kamikawa S, Hirohata S, Kusachi S

Heart and vessels   34 ( 2 )   331 - 342   2018.8

Circulating adipocyte fatty acid-binding protein is a predictor of cardiovascular events in patients with stable angina undergoing percutaneous coronary intervention International journal

Wataru Takagi, Toru Miyoshi, Masayuki Doi, Keisuke Okawa, Kazumasa Nosaka, Tomoyuki Nishibe, Naoaki Matsuo, Satoshi Hirohata, Hiroshi Ito

BMC CARDIOVASCULAR DISORDERS   17 ( 1 )   83 - 106   2017.10

EPA/AA CAN BE A PREDICTIVE FACTOR IN THE PATIENTS WITH CORONARY ARTERY DISEASE IN THE STRONG STATIN ERA

Naoaki Matsuo, Atsushi Takaishi, Nobuhiko Oonishi, Yukari Nakano, Kenzou Kagawa, Tatsuya Yamaji, Yuuichi Katou, Kazuna Hayashi, Masayuki Ueeda, Satoshi Hirohata

ATHEROSCLEROSIS   263   E196 - E197   2017.8

Diverse Functions of a Disintegrin and Metalloproteinase with Thrombospondin Motif-1 Reviewed

Satoshi Hirohata, Junko Inagaki, Takashi Ohtsuki

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   137 ( 7 )   811 - 814   2017.7

A rapid and precise method for measuring plasma apoE-rich HDL using polyethylene glycol and cation-exchange chromatography: a pilot study on the clinical significance of apoE-rich HDL measurements Reviewed International journal

Toru Ikeda, Ryoko Shinohata, Masaaki Murakami, Kazuyoshi Hina, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi, Arisa Tamura, Shinichi Usui

CLINICA CHIMICA ACTA   465   112 - 118   2017.2

Early initiation of eicosapentaenoic acid and statin treatment is associated with better clinical outcomes than statin alone in patients with acute coronary syndromes: 1-year outcomes of a randomized controlled study Reviewed International journal

Kazumasa Nosaka, Toru Miyoshi, Mutsumi Iwamoto, Masahito Kajiya, Keisuke Okawa, Saori Tsukuda, Fumi Yokohama, Masahiro Sogo, Tomoyuki Nishibe, Naoaki Matsuo, Satoshi Hirohata, Hiroshi Ito, Masayuki Doi

INTERNATIONAL JOURNAL OF CARDIOLOGY   228   173 - 179   2017.2

Subclavian steal syndrome: A case report and review of advances in diagnostic and treatment approaches Reviewed

Issei Komatsubara, Jun Kondo, Maki Akiyama, Hidemi Takeuchi, Kunio Nogami, Shinichi Usui, Satoshi Hirohata, Shozo Kusachi

Cardiovascular Revascularization Medicine   17 ( 1 )   54 - 58   2016.1

Clinical Experience : Estimation of Vascular Conditions by Means of the Analysis of the Arterial Pressure Waveform Changes in Patients with Septic Shock

39 ( 12 )   747 - 751   2015.12

Eosinophil Cationic Protein Shows Survival Effect on H9c2 Cardiac Myoblast Cells with Enhanced Phosphorylation of ERK and Akt/GSK-3 beta under Oxidative Stress

Hiroko Ishii, Shigeshi Kamikawa, Satoshi Hirohata, Akifumi Mizutani, Koji Abe, Masaharu Seno, Toshitaka Ohashi, Yoshifumi Ninomiya

ACTA MEDICA OKAYAMA   69 ( 3 )   145 - 153   2015.6

Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: A randomized, controlled study Reviewed International journal

Masayuki Doi, Kazumasa Nosaka, Toru Miyoshi, Mutsumi Iwamoto, Masahito Kajiya, Keisuke Okawa, Rie Nakayama, Wataru Takagi, Ko Takeda, Satoshi Hirohata, Hiroshi Ito

INTERNATIONAL JOURNAL OF CARDIOLOGY   176 ( 3 )   577 - 582   2014.10

Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease Reviewed International journal

Toru Miyoshi, Masayuki Doi, Shinichi Usui, Mutsumi Iwamoto, Masahito Kajiya, Ko Takeda, Kazumasa Nosaka, Rie Nakayama, Keisuke Okawa, Wataru Takagi, Kazufumi Nakamura, Satoshi Hirohata, Hiroshi Ito

ATHEROSCLEROSIS   233 ( 2 )   454 - 459   2014.4

New Estimation Method of Total Creatine Phosphokinase Release in Early Stage in Acute Myocardial Infarction

Kitawaki T, Oka H, Usui S, Hirohata S, Kusachi S

International Journal of Cardiovascular and Cerebrovascular Disease   2 ( 2 )   18 - 27   2014

Serum adipocyte fatty acid-binding protein is independently associated with complex coronary lesions in patients with stable coronary artery disease

Masahito Kajiya, Toru Miyoshi, Masayuki Doi, Shinichi Usui, Mutsumi Iwamoto, Ko Takeda, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shozo Kusachi, Kazufumi Nakamura, Hiroshi Ito

HEART AND VESSELS   28 ( 6 )   696 - 703   2013.11

Adaptive-servo ventilation combined with deep sedation is an effective strategy during pulmonary vein isolation International journal

Takashi Murakami, Hirosuke Yamaji, Kenji Numa, Hiroshi Kawamura, Masaaki Murakami, Shunichi Higashiya, Shigeshi Kamikawa, Kazuyoshi Hina, Satoshi Hirohata, Shozo Kusachi

Europace   15 ( 7 )   951 - 956   2013.7

A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer

Mikdat Bozer, Fatma Asik, Muradiye Acar, Hacer Haltas, Sibel Yenidunya, Metin Canbal, Vehap Topcu, Muhammet Ramazan Yigitoglu, Mehmet Gunduz, Esra Gunduz, Satoshi Hirohata, Kadir Demircan

TURKISH JOURNAL OF MEDICAL SCIENCES   43 ( 5 )   671 - 677   2013

Usefulness of Dabigatran Etexilate as Periprocedural Anticoagulation Therapy for Atrial Fibrillation Ablation International journal

Hirosuke Yamaji, Takashi Murakami, Kazuyoshi Hina, Shunichi Higashiya, Hiroshi Kawamura, Masaaki Murakami, Shigeshi Kamikawa, Satoshi Hirohata, Shozo Kusachi

CLINICAL DRUG INVESTIGATION   33 ( 6 )   409 - 418   2013

Reduced Diurnal Variation of Heart Rate is Associated With Increased Plasma B-Type Natriuretic Peptide Level in Patients With Atrial Fibrillation International journal

Shigeshi Kamikawa, Toru Miyoshi, Masayuki Doi, Naoko Orita, Mutsuko Sangawa, Takaaki Nakatsu, Youko Noguchi, Satoshi Hirohata, Shozo Kusachi, Kazufumi Nakamura, Hiroshi Ito

CLINICAL CARDIOLOGY   36 ( 7 )   394 - 400   2013

ADAMTSの機能

廣畑 聡

血管新生研究の最先端   208 - 216   2013

Cyclic tensile strain inhibits interleukin-1 beta and tumor ncerosis factor-alpha-induced aggrecanase in human chondrosarcoma cell line OUMS-27 by stretch-activated channles

Takashi Ohtsuki, Keiichiro Nishida, Satoshi Hirohata, Yoshifumi Ninomiya

GLYCOBIOLOGY   22 ( 11 )   1582 - 1583   2012.11

The tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis

Satoshi Hirohata, Takashi Ohtsuki, Masanari Obika, Hiroko Ogawa, Shozo Kusachi, Yoshifumi Ninomiya

GLYCOBIOLOGY   22 ( 11 )   1559 - 1559   2012.11

Impact of MDA-LDL/LDL-C and AA/EPA ratio to plaque vulnerability in patients with stable angina pectoris

Hiroaki Otsuka, Masayuki Ueeda, Takuro Masuda, Yasunori Arai, Daisuke Yamada, Nobuhiko Ohnishi, Atsushi Takaishi, Satoshi Hirohata, Shozo Kusachi, Hiroshi Ito

CIRCULATION   125 ( 19 )   E697 - E697   2012.5

Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris International journal

Mutsumi Iwamoto, Toru Miyoshi, Masayuki Doi, Ko Takeda, Masahito Kajiya, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi, Kosuke Sakane, Kazuhfumi Nakamura, Hiroshi Ito

CARDIOVASCULAR DIABETOLOGY   11 ( 26 )   26 - 26   2012.3

Sufficient pulmonary vein image quality of non-enhanced multi-detector row computed tomography for pulmonary vein isolation by catheter ablation International journal

Hirosuke Yamaji, Kazuyoshi Hina, Hiroshi Kawamura, Takashi Murakami, Masaaki Murakami, Satoshi Hirohata, Natsuki Ohmaru, Shozo Kusachi

EUROPACE   14 ( 1 )   52 - 59   2012.1

Serum hepatitis B virus DNA before liver transplantation correlates with HBV reinfection rate even under successful low-dose hepatitis B immunoglobulin prophylaxis Reviewed International journal

Tetsuya Yasunaka, Akinobu Takaki, Takahito Yagi, Yoshiaki Iwasaki, Hiroshi Sadamori, Kazuko Koike, Satoshi Hirohata, Masashi Tatsukawa, Daisuke Kawai, Hidenori Shiraha, Yasuhiro Miyake, Fusao Ikeda, Haruhiko Kobashi, Hiroaki Matsuda, Susumu Shinoura, Ryuichi Yoshida, Daisuke Satoh, Masashi Utsumi, Teppei Onishi, Kazuhide Yamamoto

HEPATOLOGY INTERNATIONAL   5 ( 4 )   918 - 926   2011.12

Residual Diastolic Cross-Bridge and Decreased Expression of Energy Metabolism Genes in Hypertrophied Rat Hearts Induced by Chronic beta-Adrenergic Stimulation

Kazufumi Nakamura, Daiji Miura, Juichiro Shimizu, Toru Miyoshi, Hiroko Toyota, Hiroshi Okuyama, Wakako Yoshikawa, Satoshi Akagi, Kunihisa Kohno, Masahi Yoshida, Hiroshi Morita, Satoshi Hirohata, Kengo Kusano, Tatsuhito Matsuo, Naoto Yagi, Hirhoshi Ito

CIRCULATION   124 ( 21 )   2011.11

ADAMTS1 Play Roles In Endothelial Cell Apoptosis

Satoshi Hirohata, Masanari Obika, Faruk Hatipoglu, Kunihiko Hatanaka, Toru Miyoshi, Hiroko Ogawa, Kaori Sakamoto, Mehmet Z. Cilek, Junko Inagaki, Hiroshi Ito, Shozo Kusachi, Yoshifumi Ninomiya

CIRCULATION   124 ( 21 )   2011.11

非糖性糖尿病性未治療高血圧患者におけるUACRの分布とhigh-normalの頻度

小川 弘子, 大丸 奈月, 中津 高明, 泉 礼司, 間島 圭一, 土岐 美沙子, 小林 亜紗子, 廣畑 聡, 池田 敏, 草地 省蔵

臨床病理   59 ( 補冊 )   115 - 115   2011.10

虚血性心疾患患者によるCAVIと冠動脈動脈硬化、左心機能の関連性の検討

小川 弘子, 三好 亨, 土井 正行, 廣畑 聡, 草地 省蔵, 小出 典男

臨床病理   59 ( 補冊 )   220 - 220   2011.10

発作性心房細動の出現率に対するarterial stiffness増加の影響

小川 弘子, 三好 亨, 土井 正行, 廣畑 聡, 草地 省蔵, 小出 典男

臨床病理   59 ( 補冊 )   220 - 220   2011.10

ARB内服中高血圧患者に対するカルシウム拮抗薬もしくは利尿剤の追加がAugmentation indexへ与える影響

三好 亨, 土井 正行, 小川 弘子, 廣畑 聡, 草地 省蔵, 小出 典男, 伊藤 浩

臨床病理   59 ( 補冊 )   219 - 219   2011.10

急性冠症候群患者における血清ADAMTS1レベルの上昇

廣畑 聡, 小比賀 真就, 幡中 邦彦, 小川 弘子, 三好 亨, 石井 裕子, 坂本 かおり, 草地 省蔵, 伊藤 浩, 二宮 善文

臨床病理   59 ( 補冊 )   116 - 116   2011.10

Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients

Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Shinichi Usui, Hiroko Ogawa, Kosuke Sakane, Reishi Izumi, Yoshifumi Ninomiya, Shozo Kusachi

HEART AND VESSELS   26 ( 4 )   408 - 413   2011.7

アンジオテンシンII受容体拮抗薬(オルメサルタン)によるサイトカイン発現抑制効果と心機能保持効果

大月 孝志, 篠畑 綾子, 廣畑 聡, 草地 省蔵, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   43回・58回   126 - 126   2011.5

炎症標的化金コロイド内包リポソームのリウマチ関節炎症部位への集積

古谷 満寿美, 松本 衣未, 美名口 順, 小川 弘子, 古松 毅之, 廣畑 聡, 二宮 善文, 西田 圭一郎, 大塚 愛二, 大橋 俊孝

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   43回・58回   118 - 118   2011.5

ANTI-INFLAMMATORY EFFECT OF OLMESARTAN ON CORONARY PLAQUE PROGRESSION, FINDING FROM THE IMPACT OF OLMESARTAN ON PROGRESSION OF CORONARY ATHEROSCLEROSIS: EVALUATION BY INTRAVASCULAR ULTRASOUND (OLIVUS) TRIAL

Toru Miyoshi, Atsushi Hirohata, Shozo Kusachi, Satoshi Hirohata, Kazufumi Nakamura, Hiroshi Morita, Kengo Kusano, Hiroshi Ito

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 14 )   E604 - E604   2011.4

IMPACT OF INCREASED ARTERIAL STIFFNESS AND WAVE REFLECTION ON THE PREVALENCE OF PAROXYSMAL ATRIAL FIBRILLATION

Toru Miyoshi, Msayuki Doi, Satoshi Hirohata, Shozo Kusachi, Kazufumi Nakamura, Satoshi Nagase, Kunihisa Kono, Hiroshi Morita, Kengo Kusano, Hiroshi Ito

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   57 ( 14 )   E563 - E563   2011.4

Association of serum levels of arachidonic acid and eicosapentaenoic acid with prevalence of major adverse cardiac events after acute myocardial infarction

Masayuki Ueeda, Takenori Doumei, Yoichi Takaya, Nobuhiko Ohnishi, Atsushi Takaishi, Satoshi Hirohata, Toru Miyoshi, Ryoko Shinohata, Shinichi Usui, Shozo Kusachi

HEART AND VESSELS   26 ( 2 )   145 - 152   2011.3

Distribution Pattern of Urine Albumin Creatinine Ratio and the Prevalence of High-Normal Levels in Untreated Asymptomatic Non-Diabetic Hypertensive Patients

Natsuki Ohmaru, Takaaki Nakatsu, Reishi Izumi, Keiichi Mashima, Misako Toki, Asako Kobayashi, Hiroko Ogawa, Satoshi Hirohata, Satoru Ikeda, Shozo Kusachi

INTERNAL MEDICINE   50 ( 16 )   1621 - 1629   2011

Significant relationship between changes in brachial-ankle pulse wave velocity relative to blood pressure elevation and coronary artery disease Reviewed International journal

Issei Komatsubara, Shinichi Inoue, Rie Koumoto, Shigeru Matano, Tomoki Kitawaki, Satoshi Hirohata, Toru Miyoshi, Hiroko Ogawa, Ryoko Shinohata, Shozo Kusachi

CORONARY ARTERY DISEASE   21 ( 7 )   407 - 413   2010.11

Serum Adipocyte Fatty Acid-Binding Protein is Associated With Coronary Lesion Complexity in Patients With Coronary Artery Disease

Masayuki Doi, Toru Miyoshi, Mutsumi Iwamoto, Kunio Nogami, Kajiya Masashi, Ko Takeda, Satoshi Hirohata, Shozo Kusachi, Hiroshi Ito

CIRCULATION   122 ( 21 )   2010.11

Chronic Kidney Disease is a Strong Predictor Related to the Severity of Coronary Artery Lesion in Patients with Stable Angina Pectoris

Kazuhiro Dan, Masayuki Ueeda, Hiroaki Ohtsuka, Satoko Ugawa, Nobuhiko Ohnishi, Atsushi Takaishi, Satoshi Hirohata, Shozo Kusachi, Kengo Kusano, Hiroshi Ito

CIRCULATION   122 ( 2 )   E363 - E364   2010.7

Combination Therapy of Calcium Channel Blocker and Angiotensin II Receptor Blocker Reduces Augmentation Index in Hypertensive Patients Reviewed International journal

Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Shigeshi Kamikawa, Shinichi Usui, Youko Kaji, Kosuke Sakane, Hiroko Ogawa, Yoshifumi Ninomiya, Shozo Kusachi

AMERICAN JOURNAL OF THE MEDICAL SCIENCES   339 ( 5 )   433 - 439   2010.5

AHR (Acute hypoxia responsive element) As a New Tool Detecting Acute Hypoxia

Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Yoshifumi Ninomiya

FASEB JOURNAL   24   2010.4

Cardio-Ankle Vascular Index is Independently Associated with the Severity of Coronary Atherosclerosis and Left Ventricular Function in Patients with Ischemic Heart Disease Reviewed

Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Kosuke Sakane, Shigeshi Kamikawa, Tomoki Kitawaki, Youko Kaji, Kengo Fukushima Kusano, Yoshifumi Ninomiya, Shozo Kusachi

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   17 ( 3 )   249 - 258   2010

Effect of Cilnidipine on Normal to Marginally Elevated Urine Albumin-Creatinine Ratio in Asymptomatic Non-Diabetic Hypertensive Patients An Exponential Decay Curve Analysis Reviewed International journal

Takaaki Nakatsu, Shinji Toyonaga, Keiichi Mashima, Yoko Yuki, Aya Nishitani, Hiroko Ogawa, Toru Miyoshi, Satoshi Hirohata, Reishi Izumi, Shozo Kusachi

CLINICAL DRUG INVESTIGATION   30 ( 10 )   699 - 706   2010

A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification

Kanae Kumagishi, Keiichiro Nishida, Tomoichiro Yamaai, Ryusuke Momota, Shigeru Miyaki, Satoshi Hirohata, Ichiro Naito, Hiroshi Asahara, Yoshifumi Ninomiya, Aiji Ohtsuka

ARCHIVES OF HISTOLOGY AND CYTOLOGY   72 ( 3 )   175 - 185   2009.11

Association of Increased Plasma Adipocyte Fatty Acid-binding Protein With Coronary Artery Disease in Men

Shunichi Higashiya, Masayuki Doi, Kunio Nogami, Mutsumi Iwamoto, Akihisa Yumoto, Kou Takeda, Masayuki Ueeda, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi, Yoshifumi Ninomiya, Hiroshi Ito

CIRCULATION   120 ( 18 )   S397 - S398   2009.11

A Novel Cationic Protein Reduced Infracted Size and Protected Myocytes From Oxidative Stress Through Modification of Akt Signaling

Shigeshi Kamikawa, Satoshi Hirohata, Syougo Watanabe, Takashi Ohtsuki, Toru Miyoshi, Hiroko Ogawa, Shozo Kusachi, Masaharu Senoo, Yoshifumi Ninomiya, Hiroshi Itoh

CIRCULATION   120 ( 18 )   S888 - S889   2009.11

ADAMTS-1 is an Endothelial Cell-specific Hypoxia-inducible Gene

Satoshi Hirohata, Faruk O. Hatipoglu, Toru Miyoshi, Hiroko Ogawa, Masanari Obika, Shigeshi Kamikawa, Shozo Kusachi, Hiroshi Itoh, Yoshifumi Ninomiya

CIRCULATION   120 ( 18 )   S1172 - S1172   2009.11

Augmentation index is associated with B-type natriuretic peptide in patients with paroxysmal atrial fibrillation International journal

Youko Kaji, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Kosuke Sakane, Tomoki Kitawaki, Shozo Kusachi, Kengo Fukushima Kusano, Hiroshi Ito

HYPERTENSION RESEARCH   32 ( 7 )   611 - 616   2009.7

IDENTIFICATION OF NF-kappa B BINDING ELEMENTS IN HUMAN ADAMTS9 PROMOTER

Kadir Demircan, Esra Gunduz, Mehmet Zeynel Cilek, Omer Faruk Hatipoglu, Kursat Oguz Yaykasli, Mehmet Gunduz, Yoshifum Ninomiya, Satoshi Hirohata

IUBMB LIFE   61 ( 3 )   354 - 354   2009.3

Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention International journal

Toru Miyoshi, Satoshi Hirohata, Tadahisa Uesugi, Minoru Hirota, Hirornichi Ohnishi, Kunio Nogami, Kunihiko Hatanaka, Hiroko Ogawa, Shinichi Usui, Shozo Kusachi

CLINICA CHIMICA ACTA   401 ( 1-2 )   3 - 7   2009.3

THE 3 '-UNTRANSLATED REGION OF THE ADAMTS1 REGULATES ITS EXPRESSION

Omer Faruk Hatipoglu, Satoshi Hirohata, Kursat Oguz Yaykasli, Mehmet Zeynel Cilek, Kadir Demircan, Ryoko Shinohata, Shozo Kusachi, Yoshifumi Ninomiya

IUBMB LIFE   61 ( 3 )   367 - 367   2009.3

UTILIZATION OF ADAMTSI AS A NEW TOOL FOR DETECTING HYPOXIA

Mehmet Zeynel Cilek, Satoshi Hirohata, Omer Faruk Hatipoglu, Kadir Demircan, Junko Inagaki, Tomoko Yonezawa, Toshikata Oohashi, Yoshifumi Ninomiya

IUBMB LIFE   61 ( 3 )   357 - 358   2009.3

ADAMTS1の血管新生阻害機能の解析 血管内皮細胞に対する影響

高橋 克之, 廣畑 聡, 小比賀 真就, 三好 亨, 小川 弘子, 草地 省蔵, 二宮 善文

日本薬学会年会要旨集   129年会 ( 3 )   218 - 218   2009.3

マウス成長軟骨におけるADAMTS-9発現とその役割について

熊岸 加苗, 西田 圭一郎, 百田 龍輔, 山合 友一朗, 廣畑 聡, Kadir Demircan, 内藤 一郎, 二宮 善文, 大塚 愛二

解剖学雑誌   84 ( Suppl. )   139 - 139   2009.3

Hyaluronan receptors involved in cytokine induction in monocytes Reviewed International journal

Hitoshi Yamawaki, Satoshi Hirohata, Toru Miyoshi, Katsuyuki Takahashi, Hiroko Ogawa, Ryoko Shinohata, Kadir Demircan, Shozo Kusachi, Kazuhide Yamamoto, Yoshifumi Ninomiya

GLYCOBIOLOGY   19 ( 1 )   83 - 92   2009.1

Increased Augmentation Index of the Radial Pressure Waveform in Patients with Paroxysmal Atrial Fibrillation International journal

Masayuki Doi, Toru Miyoshi, Satoshi Hirohata, Akihiro Iwabu, Youkou Tominaga, Youko Kaji, Shigeshi Kamikawa, Kosuke Sakane, Tomoki Kitawaki, Kengo F. Kusano, Shozo Kusachi

CARDIOLOGY   113 ( 2 )   138 - 145   2009

Human eosinophil cationic protein enhances stress fiber formation in Balb/c 3T3 fibroblasts and differentiation of rat neonatal cardiomyocytes International journal

Takayuki Fukuda, Miki Iwata, Midori Kitazoe, Takashi Maeda, David Salomon, Satoshi Hirohata, Katsuyuki Tanizawa, Shun'ichi Kuroda, Masaharu Seno

GROWTH FACTORS   27 ( 4 )   228 - 236   2009

Serum N-3 Polyunsaturated Fatty Acid Levels Correlate With the Extent of Coronary Plaques and Calcifications in Patients With Acute Myocardial Infarction

Masayuki Ueeda, Takenori Doumei, Yoichi Takaya, Ryoko Shinohata, Yusuke Katayama, Nobuhiko Ohnishi, Atsushi Takaishi, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi

CIRCULATION JOURNAL   72 ( 11 )   1836 - 1843   2008.11

Serum Adipocyte Fatty Acid-Binding Protein Levels are Independently Associated with Coronary Atherosclerosis

Toru Miyoshi, Atsushi Hirohata, Shinichi Usui, Keizo Yamamoto, Kazuyoshi Hina, Satoshi Hirohata, Shozo Kusachi, Yoshifumi Ninomiya, Kengo F. Kusano

CIRCULATION   118 ( 18 )   S470 - S470   2008.10

The Impact of Increased Augmentation Index of Radial Pressure Waveform on Paroxysmal Atrial Fibrillation

Youko Kaji, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Tadahisa Uesugi, Shigeshi Kamikawa, Kosuke Sakane, Shozo Kusachi, Kengo F. Kusano

CIRCULATION   118 ( 18 )   S730 - S730   2008.10

Prone position is essential for detection of pulmonary vein pseudostenosis by enhanced multidetector computed tomography in patients who undergo pulmonary vein isolation

Hirosuke Yamaji, Kazuyoshi Hina, Hiroshi Kawamura, Takashi Murakami, Masaaki Murakami, Keizo Yamamoto, Atsushi Hirohata, Toru Miyoshi, Satoshi Hirohata, Shozo Kusachi

CIRCULATION JOURNAL   72 ( 9 )   1460 - 1464   2008.9

Association of corrected QT dispersion with symptoms improvement in patients receiving cardiac resynchronization therapy

Kazuyoshi Hina, Hiroshi Kawamura, Takashi Murakami, Keizo Yamamoto, Hirosuke Yamaji, Masaaki Murakami, Satoshi Hirohata, Hiroko Ogawa, Kohsuke Sakane, Shozo Kusachi

HEART AND VESSELS   23 ( 5 )   325 - 333   2008.9

Higher incidence and serum levels of minor cardiac biomarker elevation in sirolimus-eluting stent (Cypher) than bare metal stent implantations Reviewed International journal

Tetsushi Seitou, Masaaki Murakami, Issei Komatsubara, Hiroshi Kawamura, Keizo Yamamoto, Kazuyoshi Hina, Satoshi Hirohata, Ryoko Shinohata, Yoshifumi Ninomiya, Shozo Kusachi

CORONARY ARTERY DISEASE   19 ( 2 )   63 - 69   2008.3

Increased augmentation index of radial pulse wave in patients with paroxysmal atrial fibrillation

Toru Miyoshi, Masayuki Doi, Youko Kaji, Satoshi Hirohata, Shigeshi Kamikawa, Shozo Kusachi, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   51 ( 10 )   A304 - A304   2008.3

OA軟骨破壊におけるアグリカナーゼの役割

鉄永智紀, 広畑 聡, 西田圭一郎

関節外科   27   221 - 227   2008

Association of new arterial stiffness parameter, the cardio-ankle vascular index, with left ventricular diastolic function

Kosuke Sakane, Toru Miyoshi, Masayuki Doi, Satoshi Hirohata, Youko Kaji, Shigeshi Kamikawa, Hiroko Ogawa, Kunihiko Hatanaka, Tomoki Kitawaki, Shozo Kusachi, Kazuhide Yamamoto

Journal of Atherosclerosis and Thrombosis   15 ( 5 )   261 - 268   2008

Increased blood pressure levels relative to subjective feelings of intensity of exercise determined with the borg scale in male patients with hypertension International journal

Eriko Mayumi, Aya Nishitani, Yoko Yuki, Takaaki Nakatsu, Shinji Toyonaga, Keiichi Mashima, Hiroko Ogawa, Satoshi Hirohata, Shinichi Usui, Ryoko Shinohata, Kousaku Sakaguchi, Shozo Kusachi

CLINICAL AND EXPERIMENTAL HYPERTENSION   30 ( 3-4 )   191 - 201   2008

Serum activin a level is associated with infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention

Toru Miyoshi, Satoshi Hirohata, Tadahisa Uesugi, Minoru Hirota, Hiromichi Ohnishi, Kunio Nogami, Shozo Kusachi, Tohru Ohe

CIRCULATION   116 ( 16 )   711 - 711   2007.10

Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population

Kunihiko Hatanaka, Masayuki Doi, Satoshi Hirohata, Shigeshi Kamikawa, Yoko Kaji, Tsutomu Katoh, Shozo Kusachi, Yoshifumi Ninomiya, Tohru Ohe

CIRCULATION JOURNAL   71 ( 6 )   904 - 910   2007.6

ADAMTS1は内皮細胞特異的に細胞浸潤を抑制する

廣畑 聡, 小比賀 真就, 小川 弘子, 三好 亨, Cilek Mehmet Zeynel, Demircan Kadir, Hatipoglu Omer Faruk, 草地 省蔵, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   39回・54回   134 - 134   2007.5

がん細胞株におけるADAMTS1の発現レベルの検討

メフメット・ゼネユル・チレッキ, 廣畑 聡, カディール・デミルジャン, オメル・ファルク・ハティポール, 小川 弘子, 米澤 朋子, 草地 省蔵, 大橋 俊孝, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   39回・54回   144 - 144   2007.5

マウス成長軟骨におけるADAMTS-9発現の検討

熊岸 加苗, 西田 圭一郎, 百田 龍輔, 山合 友一朗, 広畑 聡, Demircan Kadir, 内藤 一郎, 二宮 善文, 大塚 愛二

解剖学雑誌   82 ( Suppl. )   150 - 150   2007.3

Development of an automatic Doppler flow signal detection system: variability of pulmonary and aortic peak flow velocity

Chiho Morita, Takaaki Nakatsu, Shozo Kusachi, Tomoki Kitawaki, Shinichi Usui, Kazuo Tobe, Shinji Toyonaga, Hiroko Ogawa, Satoshi Hirohata, Yasushi Shiratori

JOURNAL OF MEDICAL ULTRASONICS   34 ( 1 )   37 - 42   2007

Decreased serum levels of interferon gamma inducible protein 10 (IP-10) in acute myocardial infarction patients after successful primary percutaneous coronary intervention are associated with a smaller infarct size

Satoshi Hirohata, Kazuya Koten, Shinichi Usui, Hiroko Ogawa, Hitoshi Yamawaki, Masanari Obika, Mutsurni Iwamoto, Yasushi Shiratori, Shozo Kusachi, Tohru Ohe

CIRCULATION   114 ( 18 )   744 - 744   2006.10

The balance of n6/n3 polyunsaturated fatty acid (PUFAs) is an important determinant factor of prognosis after acute myocardial infarction

Takenori Domei, Masayuki Ueeda, Yoichi Takaya, Nobuhiko Ohnishi, Atsushi Takaishi, Masanobu Imai, Satoshi Hirohata, Shozo Kusachi, Toru Ohe

CIRCULATION   114 ( 18 )   463 - 463   2006.10

Statin treatment accelerated neovessel formation in the border zone of the infarcted heart: Architectural study of vascular casts by scanning electron microscopy

Mutsumi Iwamoto, Satoshi Hirohata, Masahiko Maruyama, Kunihiko Hatanaka, Hiroko Ogawa, Yasushi Shiratori, Shozo Kusachi, Tohru Ohe

CIRCULATION   114 ( 18 )   206 - 206   2006.10

Tumor-specific expression of the RGD-alpha 3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice International journal

Toru Miyoshi, Satoshi Hirohata, Hiroko Ogawa, Masayuki Doi, Masanari Obika, Tomoko Yonezawa, Yoshikazu Sado, Shozo Kusachi, Satoru Kyo, Seiji Kondo, Yasushi Shiratori, Billy G. Hudson, Yoshifumi Ninomiya

FASEB JOURNAL   20 ( 11 )   1904 - +   2006.9

ヒト末梢血単球成分におけるヒアルロン酸の炎症反応誘導機構の解析

山脇 均, 廣畑 聡, 小川 弘子, 二宮 善文, 草地 省蔵, 白鳥 康史, 大江 透

日本動脈硬化学会総会プログラム・抄録集   38回   240 - 240   2006.7

Coronary pressure measurement to identify the lesion requiring percutaneous coronary intervention in equivocal tandem lesions International journal

Minoru Hirota, Kohichiro Iwasaki, Keizo Yamamoto, Shozo Kusachi, Kazuyoshi Hina, Satoshi Hirohata, Masaaki Murakami, Shigeshi Kamikawa, Takashi Murakami, Yasushi Shiratori

CORONARY ARTERY DISEASE   17 ( 2 )   181 - 186   2006.3

Nicorandil reduces the incidence of minor cardiac marker elevation after coronary stenting International journal

M Murakami, K Iwasaki, S Kusachi, K Hina, M Hirota, S Hirohata, S Kamikawa, M Sangawa, K Yamamoto, Y Shiratori

INTERNATIONAL JOURNAL OF CARDIOLOGY   107 ( 1 )   48 - 53   2006.2

Versican is induced in infiltrating monocytes in myocardial infarction International journal

K Toeda, K Nakamura, S Hirohata, OF Hatipoglu, K Demircan, H Yamawaki, H Ogawa, S Kusachi, Y Shiratori, Y Ninomiya

MOLECULAR AND CELLULAR BIOCHEMISTRY   280 ( 1-2 )   47 - 56   2005.12

Coronary pressure measurement to determine treatment strategy for equivocal left main coronary artery lesions

S Suemaru, K Iwasaki, K Yamamoto, S Kusachi, K Hina, S Hirohata, M Hirota, M Murakami, S Kamikawa, T Murakami, Y Shiratori

HEART AND VESSELS   20 ( 6 )   271 - 277   2005.11

Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas International journal

M Gunduz, H Nagatsuka, K Demircan, E Gunduz, B Cengiz, M Ouchida, H Tsujigiwa, E Yamachika, K Fukushima, L Beder, S Hirohata, Y Ninomiya, K Nishizaki, K Shimizu, N Nagai

GENE   356 ( 1-2 )   109 - 117   2005.8

バーシカンはラット心筋梗塞において一時的に上昇し,その発現は再灌流傷害により増強する

廣畑 聡, 小川 弘子, 山脇 均, 小比賀 真就, 草地 省蔵, 白鳥 康史, 大江 透, 二宮 善文

日本動脈硬化学会総会プログラム・抄録集   37回   197 - 197   2005.7

Significant correlation of recruitable coronary collateral blood flow determined by coronary wedge pressure with ST-segment elevation during coronary occlusion International journal

S Karnikawa, K Iwasaki, K Yamamoto, S Kusachi, K Hina, S Hirohata, M Murakami, M Hirota, T Murakami, Y Shiratori

CORONARY ARTERY DISEASE   16 ( 4 )   231 - 236   2005.6

5) Identification and Characterization of a novel rat link protein gene : Lp3/Hapln3

小川 弘子, 廣畑 聡, 三好 亨, 村上 充, 白鳥 康史, 大橋 俊孝, 二宮 善文, 草地 省蔵, 佐田 政隆

Circulation journal : official journal of the Japanese Circulation Society   68 ( 0 )   938 - 938   2004.10

Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction International journal

K Nakamura, S Hirohata, T Murakami, T Miyoshi, K Demircan, T Oohashi, H Ogawa, K Koten, K Toeda, S Kusachi, Y Ninomiya, Y Shiratori

JOURNAL OF BIOCHEMISTRY   136 ( 4 )   439 - 446   2004.10

新規ラットlink protein geneの同定と特性 Lp3/Hapln3(Identification and Characterization of a novel rat link protein gene: Lp3/Hapln3)

小川 弘子, 廣畑 聡, 三好 亨, 村上 充, 白鳥 康史, 大橋 俊孝, 二宮 善文, 草地 省蔵, 佐田 政隆

Circulation Journal   68 ( Suppl.III )   938 - 938   2004.10

Combination of caspase transfer using the human telomerase reverse transcriptase promoter and conventional therapies for malignant glioma cells International journal

H Takeuchi, T Kanzawa, Y Kondo, T Komata, S Hirohata, S Kyo, S Kondo

INTERNATIONAL JOURNAL OF ONCOLOGY   25 ( 1 )   57 - 63   2004.7

新規マトリックスリンクプロテインLp3/Hapln3 クローニングおよびその発現解析

小川 弘子, 廣畑 聡, 大橋 俊孝, 佐田 政隆, 村上 充, 二宮 善文, 草地 省蔵, 白鳥 康史, 大江 透

日本動脈硬化学会総会プログラム・抄録集   36回   197 - 197   2004.7

Spatially and temporally different expression of osteonectin and osteopontin in the infarct zone of experimentally induced myocardial infarction in rats

Komatsubara, I, T Murakami, S Kusachi, K Nakamura, S Hirohata, J Hayashi, S Takemoto, C Suezawa, Y Ninomiya, Y Shiratori

CARDIOVASCULAR PATHOLOGY   12 ( 4 )   186 - 194   2003.7

Osteogenic protein-1 reduces intercellular adhesion molecule-1 messenger RNA expression, infarct size and TUNEL-positive cardiomyocytes in ischemia/reperfusion rat hearts. Reviewed International journal

Hayashi J, Kusachi S, Murakami T, Miyoshi T, Nakamura K, Koten K, Ogawa H, Hirohata S, Ninomiya Y, Shiratori Y

Experimental and clinical cardiology   8 ( 4 )   195 - 200   2003

胆嚢炎に続発した感染性腹部大動脈瘤の一例

三好亨, 広畑敦, 小天和也, 土井正行, 廣畑 聡, 瀬崎悟之, 村上充, 草地省蔵, 白鳥康史

Circulation Journal   2003

Intense response of heart rate with pronounced suppression of high-frequency power of heart rate variability to early morning exercise with high-intensity load Reviewed International journal

J Ueta, T Nakatsu, T Murakami, S Toyonaga, S Hirohata, K Mashima, M Sangawa, S Kusachi, Y Shiratori

BIOMEDICINE & PHARMACOTHERAPY   56 ( SUPPL. 2 )   353S - 358S   2002

A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter

T Komata, S Koga, S Hirohata, M Takakura, IM Germano, M Inoue, S Kyo, S Kondo, Y Kondo

INTERNATIONAL JOURNAL OF ONCOLOGY   19 ( 5 )   1015 - 1020   2001.11

Increased expression of biglycan mRNA in pressure-overloaded rat heart

Y Ayada, S Kusachi, T Murakami, S Hirohata, S Takemoto, Komatsubara, I, J Hayashi, A Iwabu, Y Ninomiya, T Tsuji

CLINICAL AND EXPERIMENTAL HYPERTENSION   23 ( 8 )   633 - 643   2001.11

ラット心筋梗塞モデルでの新生血管におけるオステオネクチンmRNAの発現の経時的変化の検討

前田 弘子, 村上 充, 廣畑 聡, 中村 圭吾, 岩部 明弘, 綾田 陽子, 瀬崎 悟之, 竹本 俊二, 小松原 一正, 草地 省蔵

Japanese Circulation Journal   65 ( Suppl.III )   807 - 807   2001.10

ラット実験的心筋梗塞モデルにおけるトロンボスポンジン-1mRNA発現の経時的変化の検討

中村 圭吾, 廣畑 聡, 岩部 明弘, 綾田 陽子, 前田 弘子, 竹本 俊二, 瀬崎 悟之, 小松原 一正, 十枝 健一, 村上 充

マトリックス研究会大会   ( 48 )   70 - 70   2001.4

Spatial changes of gelatinolytic activity in myocardial infarction in rats

Takashi Murakami, Shozo Kusachi, Satoshi Hirohata, Chisato Suezawa, Syunji Takemoto, Satoshi Sezaki, Takao Tsuji, Yoshifumi Ninomiyal

Keio Journal of Medicine   50   54 - 63   2001.1

新しい細胞外マトリックス分解酵素ＡＤＡＭＴＳファミリー

廣畑 聡

生化学   73,11,1333-1337   2001

Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11

Satoshi Hirohata, Michael F. Seldin, Suneel S. Apte

Genomics   Nov 15;54(1):178-9 ( 1 )   178 - 179   1998.11

平成14-15年度科学研究費補助金（基盤研究B）成果報告書

2004 

平成13-14年度科学研究費補助金（基盤研究B）成果報告書

2003 

Advancement of Life Science

Roan AMVO Publishing Company, Taipei  2003 

APP669切断酵素ADAMTS4の同定

金子直樹, 横山雅シャラ, 池村健太郎, 松崎将也, GABRIEL Opoku, 伊永章史, 関谷禎規, 岩本慎一, 廣畑聡, 田中耕一, 富田泰輔

Dementia Japan   36 ( 4 )   2022

Expression of Osteopontin in non-alcoholic steatohepatitis (NASH) fibrosis

安藤亮典, 畑本早紀子, 中野愛梨, 池村健太郎, 兒玉慎太郎, OPOKU Gabriel, 山元修成, 稲垣純子, 今重之, HATIPOGLU Omer Faruk, 渡辺彰吾, 廣畑聡

日本結合組織学会学術大会抄録集   53rd   2021

XO阻害薬フェブキソスタットによる抗酸化作用は肝臓・血管系を保護する

柿本麻衣, 藤井萌, 佐藤生弥, 山元修成, 本間宏基, 奥川友葉, 柴田桃里, 小松千尋, 廣畑聡, 渡辺彰吾

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   53rd   2021

フルクトース負荷による尿酸上昇がNASHと動脈硬化に及ぼす影響

藤井萌, 柿本麻衣, 山元修成, 佐藤生弥, 本間宏基, 小松千尋, 奥川友葉, 柴田桃里, 廣畑聡, 渡辺彰吾

日本動脈硬化学会総会・学術集会プログラム・抄録集(Web)   53rd   2021

国立大学臨書検査技師教育協議会の取り組みと日本臨床検査学教育協議会との連携

廣畑 聡

臨床検査学教育   2019.8

BMPR2変異を伴うPAHにおけるSMCのエピジェネティックな変化に対する低酸素の重要な役割(Crucial Role of Hypoxia in Epigenetic Changes of SMCs from PAH with BMPR2 Mutation) Reviewed

中村 一文, 赤木 達, 斎藤 幸弘, 江尻 健太郎, 三好 亨, 吉田 賢司, 廣畑 聡, 伊藤 浩

日本循環器学会学術集会抄録集   83回   OJ10 - 3   2019.3

変形性関節症関連microRNAの検索並びに解析

大月 孝志, オメル・ファルク・ハティポール, 品岡 玲, メフメット・ゼイネル・チレッキ, 西村 拓人, 浅野 恵一, 稲垣 純子, 大橋 俊孝, 西田 圭一郎, 岡田 保典, 廣畑 聡

日本結合組織学会学術大会プログラム・抄録集   50回   111 - 111   2018.6

RNA干渉法による特発性肺線維症に重要な分子のサイレンシング

ハティポール・オメル・ファルク, エユプ・ウチュテペ, グンデゥズ・エスラ, グンデゥズ・メーメット, 大月 孝志, 稲垣 純子, 廣畑 聡

日本結合組織学会学術大会プログラム・抄録集   50回   146 - 146   2018.6

炎症性サイトカイン誘導性マトリックス分解酵素発現のイオンチャネルを介した抑制とその機構解析

大月 孝志, 品岡 玲, 品岡 加苗, Mehmet Cilek, Omer Hatipoglu, 西村 拓人, 稲垣 純子, 西田 圭一郎, 廣畑 聡

生命科学系学会合同年次大会   2017年度   [3P - 1164]   2017.12

がん微小環境の実体 がん微小環境におけるバーシカン分解酵素ADAMTSの局在と血管新生におけるバーシカンの意義

浅野 恵一, 廣畑 聡, 大月 孝志, オメル・ファルク・ハティポール, 稲垣 純子, 大橋 俊孝

日本結合組織学会学術大会プログラム・抄録集   49回   56 - 56   2017.6

関節の修復・再生 メカニカルストレスの軟骨細胞に及ぼす多彩な作用 マトリックス合成促進と炎症性サイトカイン誘導性マトリックス分解活性抑制

大月 孝志, 品岡 玲, 熊岸 加苗, 岡, メフメット・ゼイネル・チレッキ, オメル・ファルク・ハティポール, 稲垣 純子, 西田 圭一郎, 廣畑 聡

日本結合組織学会学術大会プログラム・抄録集   49回   62 - 62   2017.6

細胞外マトリックス分解酵素ADAMTS1の多様性

廣畑 聡, 稲垣純子, 大月孝志

薬学雑誌   37 ( 7 )   811 - 814   2017

変形性関節症へのヒアルロン酸投与、いつ投与すべきか? 動物モデルからの知見

大月 孝志, 品岡 玲, 熊岸 加苗, 河野 真優美, 篠原 真歩, 浅野 恵一, 稲垣 純子, 大橋 俊孝, 西田 圭一郎, 廣畑 聡

日本結合組織学会学術大会プログラム・抄録集   48回   60 - 60   2016.6

伸展刺激の強度による細胞外マトリックスタンパクおよびマトリックス分解酵素発現への影響

大月 孝志, 金道 幸子, 長谷川 みさ, 稲垣 純子, 浅野 恵一, 障子 友理, 熊岸 加苗, 西田 圭一郎, 大橋 俊孝, 廣畑 聡

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回   [2P0078] - [2P0078]   2015.12

ADAMTSによるバーシカン分解と腫瘍内血管新生の関連

浅野 恵一, 稲垣 純子, 障子 友理, Hofmann Matthias, 大月 孝志, 廣畑 聡, 大橋 俊孝

日本結合組織学会学術大会プログラム・抄録集   47回   114 - 114   2015.5

メカニカルストレスが軟骨様細胞の細胞外マトリックス及びマトリックス分解酵素のmRNA発現へ示す効果の検討

大月 孝志, 金道 幸子, 長谷川 みさ, 平田 彩, 川地 輝幸, 浅野 恵一, 稲垣 純子, 障子 友理, 熊岸 加苗, 西田 圭一郎, 大橋 俊孝, 廣畑 聡

日本結合組織学会学術大会プログラム・抄録集   47回   134 - 134   2015.5

関節軟骨造影剤を用いた関節軟骨プロテオグリカンの評価

大橋 俊孝, 加来田 博貴, 芳谷 学, 山田 翔也, 大月 孝志, 廣畑 聡, 二宮 善文, 西田 圭一郎

日本結合組織学会学術大会プログラム・抄録集   47回   97 - 97   2015.5

ヒアルロン酸短期投与によるラット変形性関節症モデルの関節軟骨保護効果の検討

大月 孝志, 廣畑 聡, 障子 友理, 浅野 恵一, 平田 彩, 川地 輝幸, 稲垣 純子, 熊岸 加苗, 西田 圭一郎, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   46回・61回   107 - 107   2014.6

新規X線造影剤による変形性膝関節症ラット関節軟骨の高解像度マイクロCT造影

大橋 俊孝, 加来田 博貴, 芳谷 学, 大月 孝志, 大野 充昭, 山田 翔也, 前原 亜美, 廣畑 聡, 西田 圭一郎, 窪木 拓男, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   46th   106 - 106   2014.6

胎生期ADAMTS1ノックアウトマウスの解析

楠 絵里子, 稲垣 純子, 大月 孝志, 川地 輝幸, 平田 彩, 浅野 恵一, マティアス・ホフマン, 二宮 善文, 廣畑 聡

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   46回・61回   76 - 76   2014.6

ADAMTS1はVEGFCと結合してリンパ管新生を抑制する

稲垣 純子, 高橋 克之, 小川 弘子, 浅野 恵一, Hatipoglu Omer Faruk, Cile Mehmet Zeynel, 小比賀 真就, 大月 孝志, Hofmann Matthias, 草地 省蔵, 二宮 善文, 廣畑 聡

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   46th   137 - 137   2014.6

担がんマウスモデルにおけるバーシカン分解の解析

浅野 恵一, 稲垣 純子, マティアス・ホフマン, 川地 輝幸, 平田 彩, 大月 孝志, 二宮 善文, 廣畑 聡

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   46回・61回   89 - 89   2014.6

リジンオリゴマーからなる関節軟骨特異的X線プローブの創出

大橋俊孝, 芳谷学, 大野充昭, 山田翔也, 大月孝志, 前原亜美, 廣畑聡, 西田圭一郎, 窪木拓男, 加来田博貴, 二宮善文

日本軟骨代謝学会プログラム・抄録集   27th   2014

ヒアルロン酸(HA)分子量と関節軟骨保護効果の解析(in vivo & in vitro)

大月 孝志, 廣畑 聡, 浅野 恵一, 楠 絵理子, 稲垣 純子, 西田 圭一郎, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   45回・60回   74 - 74   2013.6

ADAMTSメタロプロテアーゼによる血管・リンパ管新生研究の新展開

廣畑聡, 廣畑聡, 小比賀真就, 小川弘子, 稲垣純子, 浅野恵一, 大月孝志, 草地省蔵, 二宮善文

がん研究分野の特性等を踏まえた支援活動公開シンポジウムプログラム・抄録集 平成24年度   2013

リンパ管内皮細胞に対するADAMTS1の作用とシグナル伝達

稲垣 純子, 高橋 克之, 小川 弘子, Hatipoglu Omer F, Zeynel Cilek Mehmet, 小比賀 真就, 廣畑 聡, 二宮 善文

日本生化学会大会プログラム・講演要旨集   85回   2P - 832   2012.12

ADAMTS1ノックアウトマウスの解析

廣畑 聡, ハティポール・オメル・ファルク, 楠 絵理子, チレッキ・メフメット・ゼイネル, 大月 孝志, 稲垣 純子, 草地 省蔵, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   44回・59回   57 - 57   2012.6

ADAMTS1のin vitroでのリンパ管新生阻害効果

稲垣 純子, 高橋 克之, 小川 弘子, Hatipoglu Omer F, Cilek Mehmet Zeynel, 小比賀 真就, 米澤 朋子, 大橋 俊孝, 廣畑 聡, 二宮 善文

日本生化学会大会プログラム・講演要旨集   84回   2P - 0343   2011.9

ADAMTS1は血管新生を阻害しアポトーシスを抑制する

廣畑 聡, 小比賀 真就, オメル・ファルク・ハティポール, 小川 弘子, メフメット・ゼェイネル・チレッキ, 稲垣 純子, 大月 孝志, 石井 裕子, 幡中 邦彦, 草地 省蔵, 米澤 朋子, 大橋 俊孝, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   43rd   103 - 103   2011.5

ADAMTS1は腫瘍壊死因子刺激下の内皮細胞におけるアポトーシスに関連する

オメル・ファルク・ハティポール, 小比賀 真就, 廣畑 聡, 小川 弘子, メフメット・ゼェイネル・チレッキ, 稲垣 純子, 大月 孝志, 石井 裕子, 幡中 邦彦, 草地 省蔵, 米澤 朋子, 大橋 俊孝, 二宮 善文

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集   43rd   104 - 104   2011.5

発作性心房細動の出現率に対するarterial stiffness増加の影響

小川弘子, 三好亨, 土井正行, 廣畑聡, 草地省蔵, 小出典男

臨床病理   59   2011

虚血性心疾患患者によるCAVIと冠動脈動脈硬化,左心機能の関連性の検討

小川弘子, 三好亨, 土井正行, 廣畑聡, 草地省蔵, 小出典男

臨床病理   59   2011

PP-386 腎虚血再灌流傷害におけるドキシサイクリンによる腎障害抑制効果の検討(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

河内 啓一郎, 二宮 善文, 廣畑 聡, 三好 亨, 上松 克利, 荒木 元朗, 石井 和史, 上原 慎也, 渡邉 豊彦, 雑賀 隆史, 那須 保友, 公文 裕巳

日本泌尿器科学会雑誌   102 ( 2 )   468 - 468   2011

ARB内服中高血圧患者に対するカルシウム拮抗薬もしくは利尿剤の追加がAugmentation indexへ与える影響

三好亨, 土井正行, 小川弘子, 廣畑聡, 草地省蔵, 小出典男, 伊藤浩

臨床病理   59   2011

新規急性低酸素応答配列を用いた遺伝子発現ベクターによる急性低酸素下のレポーター遺伝子の発現様式(AHR, a novel acute hypoxia-response sequence, drives reporter gene under hypoxia in vitro and in vivo)

Hatipoglu Omerf., Cilek Mehmet Z., 廣畑 聡, 小川 弘子, 稲垣 純子, 大月 孝志, 熊岸 香苗, 草地 省蔵, 二宮 善文

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   83回・33回   2P - 0260   2010.12

ADAMTS1の内皮細胞に対するアポトーシス効果の検討

HATIPOGLU Omer Faruk, 廣畑聡, 小比賀真就, CILEK Mehmet Zeynel, 小川弘子, 三好亨, 稲垣純子, 大月孝志, 草地省蔵, 米澤朋子, 大橋俊孝, 二宮善文

日本結合組織学会学術大会抄録集   42nd   2010

ADAMTS1遺伝子治療はプロテアーゼ非依存的に血管新生阻害効果を発揮し,腫瘍増大を阻害する

廣畑聡, 小比賀真就, HATIPOGLU Omer Faruk, 小川弘子, CILEK Mehmet Zeynel, 高橋克之, 稲垣純子, 三好亨, 大月孝志, 石井裕子, 草地省蔵, 米澤朋子, 大橋俊孝, 二宮善文

日本結合組織学会学術大会抄録集   42nd   2010

ADAMTS1プロモーターは急性低酸素状態の内皮細胞選択的に遺伝子発現を誘導する

CILEK Mehmet Zeynel, 廣畑聡, HATIPOGLU Omer Faruk, 小川弘子, 三好亨, 稲垣純子, 大月孝志, 大橋俊孝, 米澤朋子, 原田浩, 上川滋, 草地省蔵, 二宮善文

日本結合組織学会学術大会抄録集   42nd   2010

FRS-060 A Novel Drug Delivery System with Targeting Liposome Reduced Inflammation in Macrophages(FRS12,New Approaches to Atherosclerosis Research (IHD),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Ogawa Hiroko, Hirohata Satoshi, Hatanaka Kunihiko, Miyoshi Toru, Kamikawa Shigeshi, Iwamoto Mutsumi, Kusachi Shozo, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society   73   151 - 151   2009.3

PE-302 Relationship between Adipocyte Fatty Acid-Binding Protein and Coronary Plaque Burden : An Intravascular Ultrasound Study(PE051,Metabolic Syndrome 3 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Onoue Go, Miyoshi Toru, Hirohata atsushi, Hirohata Satoshi, Ogawa Hiroko, Kamikawa Shigeshi, Kusachi Shozo, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society   73   475 - 475   2009.3

DPE-038 Differential Effects of Calcium Channel Blocker and Diuretic in Combination with Angiotensin II Receptor Blockers on Late Systolic Pressure Augmentation(DPE07,Hypertension, Clinical (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Miyoshi Toru, Doi Masayuki, Hirohata Satoshi, Kaji Yoko, Sakane Kosuke, Kamikawa Shigeshi, Ogawa Hiroko, Kusachi Shozo, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society   73   365 - 365   2009.3

PE-208 Olmesartan Decreased Serum TGF-β Level and Protected Fibrotic Change in Rat Pressure Overload Heart(PE035,Cardiovascular Pharmacology (Basic) (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Iwamoto Mutsumi, Hirohata Satoshi, Miyoshi Toru, Ogawa Hiroko, Obika Masanari, Yamawaki Hitoshi, Kusachi Shozo, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society   73   451 - 451   2009.3

PE-204 Heart Rate Circadian Rhythm is the Strongest Factor to Determine the BNP Level in Permanent AF without LV Systolic Dysfunction(PE034,ECG/Body Surface Potential Mapping/Holter (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Kamikawa Shigeshi, Kaji Yoko, Sakane Kosuke, Miyoshi Toru, Hirohata Satoshi, Kusachi Shozo, Doi Masayuki

Circulation journal : official journal of the Japanese Circulation Society   73   450 - 450   2009.3

DPJ-068 HIF-1 Directly Induced Novel Metalloproteinase ADAMTS1 Expression and ADAMTS1 under Hypoxia Accelerated Endothelial Cell Migration(DPJ12,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Hirohata Satoshi, Ogawa Hiroko, Miyoshi Toru, Kamikawa Shigeshi, Hatanaka Kunihiko, Obika Masanari, Kusachi Shozo, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society   73   393 - 394   2009.3

PE-203 QT Prolongation and Global ST-T Change are the Characteristics of Electrocardiogram of Heat Stroke(PE034,ECG/Body Surface Potential Mapping/Holter (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nakano Yukari, Ueeda Masayuki, Ugawa Satoko, Dan Kazuhiro, Ohnishi Nobuhiko, Takaishi Atsushi, Hirohata Satoshi, Kusachi Shozo

Circulation journal : official journal of the Japanese Circulation Society   73   450 - 450   2009.3

PE-363 Difference of Risk Factors and PUFAs between Generations and Sex in Patients of Acute Myocardinal Infarction(PE061,ACS/AMI (Clinical/Pathophysiology) 2 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Ugawa Satoko, Ueeda Masayuki, Nakano Yukari, Dan Kazuhiro, Ohnishi Nobuhiko, Takaishi Atsushi, Hirohata Satoshi, Kusachi Shozo

Circulation journal : official journal of the Japanese Circulation Society   73   491 - 491   2009.3

OE-229 Two Hyaluronan Receptors, Toll-like receptor-4 (TLR4) and CD44, Play Distinct Roles in Cytokine Induction in Monocytes(OE39,Infection/Inflammation/Immunity (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Yamawaki Hitoshi, Hirohata Satoshi, Miyoshi Toru, Kamikawa Shigeshi, Ogawa Hiroko, Obika Masanari, Iwamoto Mutsumi, Hatanaka Kunihiko, Kusachi Shozo

Circulation journal : official journal of the Japanese Circulation Society   73   232 - 232   2009.3

PE-477 Significant Increase of Cholesterol, Trigriceride and AA were Observed in AMI : From 20 Years Database in Mitoyo General Hospital(PE080,ACS/AMI (Clinical/Pathophysiology/Treatment/Basic), Angina Pectoris (Clinical) (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)

Nakano Yukari, Ueeda Masayuki, Ugawa Satoko, Dan Kazuhiro, Ohnishi Nobuhiko, Takaishi Atsushi, Hirohata Satoshi, Kusachi Shozo

Circulation journal : official journal of the Japanese Circulation Society   73   520 - 520   2009.3

ADAMTS1の血管新生阻害機能の解析:血管内皮細胞に対する影響

高橋克之, 廣畑聡, 小比賀真就, 三好亨, 小川弘子, 草地省蔵, 二宮善文

日本薬学会年会要旨集   129th ( 3 )   2009

低分子ヒアルロン酸によるサイトカイン誘導とヒアルロン酸レセプター

高橋克之, 廣畑聡, 山脇均, 三好亨, 小川弘子, 二宮善文

日本軟骨代謝学会プログラム・抄録集   22nd   2009

107) 発作性心房細動患者におけるBNPレベルの上昇とAugmentation indexとの関連(第92回日本循環器学会中国・四国合同地方会)

坂根 弘祐, 上川 滋, 三好 亨, 廣畑 聡, 土井 正行

Circulation journal : official journal of the Japanese Circulation Society   72   1041 - 1041   2008.10

PE-475 Activin A as a Novel Marker of Infarct Size in Patients with Acute Myocardial Infarction Who Undergo Percutaneous Coronary Intervention(Acute myocardial infarction, clinical(diagnosis/treatment)(07)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Miyoshi Toru, Hirohata Satoshi, Ogawa Hiroko, Hatanaka Kunihiko, Kamikawa Shigeshi, Iwamoto Mutsumi, Kusachi Shozo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society   72   479 - 479   2008.3

PJ-814 Unique Three-dimensional Construction of Neovessel Formation by Fluvastatin Treatment in the Infarcted Myocardium(Cardiovascular pharmacology, basic / clinical(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Ogawa Hiroko, Hirohata Satoshi, Maruyama Masahiko, Miyoshi Toru, Yamawaki Hitoshi, Iwamoto Mutsumi, Kamikawa Shigeshi, Hatanaka Kunihiko, Kusachi Shozo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society   72   716 - 716   2008.3

OE-190 In vivo Imaging of Atherosclerosis with Novel Targeting Liposomes(Atherosclerosis, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Hatanaka Kunihiko, Hirohata Satoshi, Ogawa Hiroko, Miyoshi Toru, Kamikawa Shigeshi, Iwamoto Mutsumi, Kusachi Shozo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society   72   228 - 228   2008.3

OE-270 Cardiac Myoblast Differentiation Promoting Factor Reduced Infarct Size and Preserved Cardiac Function in Rat Myocardial Infarction Model(Acute myocardial infarction, basic(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Kamikawa Shigeshi, Hirohata Satoshi, Maruyama Masahiko, Ogawa Hiroko, Miyoshi Toru, Yamawaki Hitoshi, Iwamoto Mutsumi, Hatanaka Kunihiko, Kusachi Shozo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society   72   248 - 248   2008.3

PE-580 siRNA Silencing Reveals Role of Vascular Cell Adhesion Molecule-1 In Vascular Smooth Muscle Cell Migration(Restenosis basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Miyoshi Toru, Hirohata Satoshi, Ogawa Hiroko, Iwamoto Mutsumi, Hatanaka Kunihiko, Kamikawa Shigeshi, Weibin Shi, Kusachi Shozo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society   72   505 - 505   2008.3

アンジオテンシン受容体拮抗剤による心臓肥大・線維化阻害は血圧低下と独立している

岩本睦, 廣畑聡, 小川弘子, 三好亨, 上川滋, 幡中邦彦, 山本和秀, 草地省蔵, 二宮善文

日本結合組織学会学術大会抄録集   40th   2008