Faculty Profiles - Ando Mizuo

Genetic analysis of the TP53 and EGFR genes in head and neck cancers Reviewed

Yasuhiro Ebihara, Miwako Iwai, Masafumi Yoshida, Mizuo Ando, Takahiro Asakage, Tatsuya Yamasoba, Yoshinori Murakami

Japanese Journal of Head and Neck Cancer 37 ( 1 ) 1 - 6 2011

Language：Japanese Publishing type：Research paper (scientific journal)

To identify useful molecular markers for the treatment of head and neck cancers (HNCs), mutations of the TP53 and EGFR genes were analyzed in 56 HNCs, including 39 head and neck squamous cell carcinomas (HNSCCs). No EGFR mutation was observed in the fragments of exons 18-21. By contrast, 17 of 39 (44%) HNSCCs, as well as 3 of 6 cases (50%) with salivary gland carcinoma showed TP53 mutation in the fragments of exons 5-9. The incidence of nonsense mutation was 47%, which was higher than that in previous reports in other countries, suggesting the presence of etiological factors characteristic to Japanese patients. Further clinical assessment, including drug response and prognosis, is required in HNSCCs carrying the null-type mutation of TP53.

DOI： 10.5981/jjhnc.37.1

Metastases to the lingual nodes in tongue cancer: A pitfall in a conventional neck dissection Reviewed

Mizuo Ando, Masao Asai, Takayuki Ono, Yukihiro Nakanishi, Takahiro Asakage, Tatsuya Yamasoba

AURIS NASUS LARYNX 37 ( 3 ) 386 - 389 2010.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

Some classical textbooks of anatomy provided a detailed description of the lingual nodes, which are small inconstant lymph nodes in the floor-of-mouth and the upper neck. The clinical importance of these lymph nodes in cancer therapy. however, has been underestimated so far. We previously reported an extremely poor prognosis of oral tongue cancer patients who had lesions at the root of the lingual artery and assumed that metastases in occult lingual nodes might be responsible for such lesions. This case report clearly demonstrates the distinctive draining course of the lateral lingual nodes, which may potentially be left untreated by a neck dissection. A 63-year-old Japanese male with T2 squamous cell carcinoma of the oral tongue showed multiple metastatic involvements of the lateral lingual nodes; three nodes in close contact with the sublingual gland, and one node at the root of the lingual artery. A systematic inspection of lymph nodes along the draining course of the lateral lingual nodes should be included, because a neck dissection in continuity with the primary tumor (a pull-through approach) is still inadequate for the removal of the lymph nodes at the root of the lingual artery. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.anl.2009.10.001

A clinical study of glottic carcinoma Reviewed

Kazuki Miyano, Mizuo Ando, Masafumi Yoshida, Yasuhiro Ebihara, Takahiro Asakage, Atsuro Terahara, Kazuki Miyano

Toukeibu Gan 36 ( 3 ) 322 - 326 2010

Language：English Publishing type：Research paper (scientific journal)

A clinical study was made of 179 patients with previously untreated glottic carcinoma registered in our department between 1998 and 2004. In our facility, T1 glottic cancer was treated by radiotherapy, T2 glottic cancer by radiotherapy or chemoradiotherapy using low-dose CDDP, and T3 and T4 glottic cancer by laryngectomy. The five-year cause-specific survival rate for glottic carcinoma was 95.1%, 96.5% for stage I, 96.6% for stage II, 92.9% for stage III, and 68.6% for stage IV. The five-year local control rate for early glottic carcinoma treated by radiotherapy was 83.1% for T1a, 60.7% for T1b, and 62.5% for T2. In T2 cases, the local control rate was 49.2% for treatment by radiotherapy, and 83.6% for low-dose CDDP with radiotherapy. Low-dose CDDP with radiotherapy contributes to high local control rate in T2 cases. © 2010, Japan Society for Head and Neck Cancer. All rights reserved.

DOI： 10.5981/jjhnc.36.322

Metastatic Neck Disease Beyond the Limits of a Neck Dissection: Attention to the 'Para-hyoid' Area in T1/2 Oral Tongue Cancer Reviewed

Mizuo Ando, Masao Asai, Takahiro Asakage, Waichiro Oyama, Masahisa Saikawa, Mitsuo Yamazaki, Masakazu Miyazaki, Toru Ugumori, Hiroyuki Daiko, Ryuichi Hayashi

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 39 ( 4 ) 231 - 236 2009.4

Language：English Publishing type：Research paper (scientific journal) Publisher：OXFORD UNIV PRESS

We evaluated patients with small oral tongue cancer suffering from recurrence, which develops in the intervening area between the primary site and the neck. Lesions in the area around the cornu of the hyoid bone ('para-hyoid' area) often involve the hypoglossal nerve and the root of the lingual artery, resulting in treatment failure and death.
A 10-year retrospective chart review was conducted of 248 oral tongue cancer patients with small primary tumors (T1/2). No patients who underwent postoperative radiotherapy (PORT) were included.
After excluding those who had local failure or developed new primary lesions, 6.3% of the patients were noted to have a para-hyoid lesion. A similar incidence was observed between the patients with and without previous neck dissection, 6.9% and 5.7%, respectively. All but one patient died due to uncontrolled neck disease.
Recurrent para-hyoid lesions could occur, irrespective of a previous neck dissection. In other words, the para-hyoid area is beyond the limits of a neck dissection. Once a para-hyoid lesion becomes clinically evident, it seems difficult to salvage. Therefore, a careful inspection of the area should be included intraoperatively in any type of neck dissection (i.e. elective or therapeutic) for patients with oral tongue cancer. This may be the key to improving the regional control rate of patients with small oral tongue cancer. We believe that some patients will benefit from more aggressive treatment of the neck, although PORT seems unnecessary for the majority of the patients with limited neck disease.

DOI： 10.1093/jjco/hyp001

Recurrent Cancer of the Parotid Gland: How Well Does Salvage Surgery Work for Locoregional Failure? Reviewed

Kenya Kobayashi, Kazunari Nakao, Masafumi Yoshida, Mizuo Ando, Yasuhiro Ebihara, Takahiro Asakage, Tatsuya Yamasoba

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 71 ( 5 ) 239 - 243 2009

Language：English Publishing type：Research paper (scientific journal) Publisher：KARGER

Purpose: Many articles have discussed the clinical features of previously untreated parotid cancer, but the clinical characteristics and treatment of recurrent parotid cancer have not yet been fully described. Materials: We retrospectively reviewed 20 patients with recurrent parotid cancer and analyzed the therapeutic strategies and the prognostic factors. Results: Twelve patients (60%) underwent definitive surgery, including 3 who underwent skull base surgery. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) in the surgery group were 66.7 and 64.1%. In the definitive surgery group, the presence of lymph node metastasis and high-grade malignant histopathology were associated with a poor prognosis (p < 0.01). On the other hand, the presence of facial palsy at presentation, the surgical margin, the time of relapse and the T stage did not affect the DFS in our series. Conclusions: The results suggest that aggressive definitive surgery may be justified for the treatment of recurrent parotid cancer. The presence of lymph node metastasis and the histopathological malignancy grade are poor prognostic factors for OS and DFS. Copyright (C) 2009 S. Karger AG, Basel

DOI： 10.1159/000236013

Mucoepidermoid carcinoma of the thyroid gland showing marked ciliation suggestive of its pathogenesis Reviewed

Mizuo Ando, Yukihiro Nakanishi, Masao Asai, Akiko Maeshima, Yoshihiro Matsuno

PATHOLOGY INTERNATIONAL 58 ( 11 ) 741 - 744 2008.11

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

Mucoepidermoid carcinoma of the thyroid gland is a rare tumor first described by Rhatigan et al. in 1977. Its pathogenesis is still controversial. With regard to its most likely origin, some authors have suggested that it arises directly from follicular epithelium whereas others have proposed that it arises from ultimobranchial body (diverticulum from the fourth pharyngeal pouch) remnants, also known as solid cell nests (SCN). Herein is reported a unique case of thyroid mucoepidermoid carcinoma. The patient, a 67-year-old man, presented with a non-tender thyroid mass and vocal cord fixation. The tumor was poorly defined, necessitating subtotal thyroidectomy with composite resection of the adjacent structures. Pathologically, the tumor cells had characteristics of mucoepidermoid carcinoma, along with layers of columnar cells showing marked ciliation resembling respiratory-type epithelium, suggesting that this rare tumor had originated from SCN. p63 immunopositivity in the tumor provided additional evidence for the pathogenesis.

DOI： 10.1111/j.1440-1827.2008.02303.x

(2) T2 lateral oropharyngeal carcinoma

Ando, M.

Otolaryngology - Head and Neck Surgery (Tokyo) 80 ( 2 ) 2008

Clinical analysis of lateral wall oropharyngeal carcinoma - A retrospective study of 32 cases Reviewed

Yasuhiro Ebihara, Masafumi Yoshida, Mizuo Ando, Kazunari Nakao, Takahiro Asakage, Atsurou Terahara, Isao Koushima

Toukeibu Gan 34 ( 4 ) 526 - 529 2008

Language：English Publishing type：Research paper (scientific journal)

We analyzed 32 cases of lateral wall oropharyngeal carcinoma treated at our institution retrospectively. Five-year overall and disease-specific survival rates were 50% and 62%, respectively. The 5-year locoregional control rate was 57%, and including salvage therapy it was improved up to 62%. It was difficult to control locoregional tumor with surgery in far-advanced cases where the tumor had invaded the nasopharynx or larynx. There is a possibility of salvage if the recurrence is solitary, but a case with multiple recurrence is difficult to salvage. © 2008, Japan Society for Head and Neck Cancer. All rights reserved.

DOI： 10.5981/jjhnc.34.526

First Panic Attack Episodes in Head and Neck Cancer Patients Who Have Undergone Radical Neck Surgery

Shimizu, K., Kinoshita, H., Akechi, T., Uchitomi, Y., Andoh, M.

Journal of Pain and Symptom Management 34 ( 6 ) 2007

Mucosa-associated lymphoid tissue lymphoma presented as diffuse swelling of the parotid gland Reviewed

M Ando, M Matsuzaki, T Murofushi

AMERICAN JOURNAL OF OTOLARYNGOLOGY 26 ( 4 ) 285 - 288 2005.7

Language：English Publishing type：Research paper (scientific journal) Publisher：W B SAUNDERS CO

Mucosa-associated lymphoid tissue (MALT) lymphoma is a distinct subtype of lymphoma. Parotid MALT lymphoma is a rare tumor that is hard to diagnose by fine-needle aspiration cytology. Therefore, partial parotidectomy is often required for a pathological diagnosis. We report a case of MALT lymphoma presented as unilateral diffuse swelling of the parotid gland, who was diagnosed by partial parotidectomy and underwent radiotherapy. (c) 2005 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.amjoto.2005.01.011