研究者詳細 - 花谷　正

論文 - 花谷　正

分割表示 88 件中 21 - 40 件目／全件表示 >>

First Synthesis of Biopterin α-D-Glucoside 査読

T. Hanaya, H. Baba, H. Yamamoto

Heterocycles 77 747 - 753 2009年

First Synthesis of a representative, Natural Pterin Glycoside: 2’-O-(α-D-Glucopyranosyl)biopterin 査読

T. Hanaya, H. Yamamoto, W. Pfleiderer

Pteridines 20 36 - 41 2009年

NMR Spectroscopic Characterization of Inclusion Complexes of Hydroxy-substituted Naphthalenes with Native and Modified β-Cyclodextrins 査読

Y. Sueishi, N. Inazumi, T. Hanaya

J. Incl. Phenom. Macrocycl. Chem. 64 ( 1-2 ) 135 - 141 2009年

Synthetic Studies on Pterin Glycosides: the First Synthesis of 2’-O-(α-D-Glucopyranosyl)biopterin 査読

T. Hanaya, H. Baba, H. Toyota, H. Yamamoto

Tetrahedron 65 7989 - 7997 2009年

AN EFFICIENT SYNTHETIC ROUTE FOR A VERSATILE CILIAPTERIN DERIVATIVE AND THE FIRST CILIAPTERIN D-MANNOSIDE SYNTHESIS 査読

Tadashi Hanaya, Hiroki Baba, Mitsunori Kanemoto, Hiroshi Yamamoto

HETEROCYCLES 76 635 - 644 2008年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

The key precursor, N(2)-(N,N-dimethylaminomethylene)-l'-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]ciliapterin (15) was efficiently prepared from D-xylose via an improved route. The first synthesis of 2'-O-(alpha-D-mannopyranosyl)ciliapterin (2c) was achieved by treatment of 15 with 2,3,4,6-tetra-O-benzoyl-alpha-D-mannnopyranosyl bromide in the presence of silver triflate and tetramethylurea, followed by removal of the protecting groups.

Web of Science

researchmap

Efficient total syntheses of natural pterin glycosides: limipterin and tepidopterin 査読

T. Hanaya, H. Baba, H. Toyota, H. Yamamoto

Tetrahedron 64 ( 9 ) 2090 - 2100 2008年

An Efficient Synthesis of 2’-O-(β-D-Ribofuranosyl)biopterin 査読

T. Hanaya, K. Torigoe, K. Soranaka, H. Fujita, H. Yamamoto, W. Pfleiderer

Pteridines 19 ( 3 ) 72 - 78 2008年

First synthesis of tepidopterin [2’-O-(2-acetamido-2-deoxy-β-D-glucopyranosyl)-L-threo-biopterin] 査読

T. Hanaya, H. Baba, H. Yamamoto

Carbohydr. Res. 342 ( 15 ) 2159 - 2162 2007年

The First Chemical Synthesis of 6-Thio-D-fructopyranose via Methyl 6-Bromo-6-deoxy-1,3-O-isopropylidene-α-D-fructofuranose as a Key Intermediate 査読

T. Hanaya, N. Sato, H. Yamamoto

Heterocycles 71 517 - 522 2007年

An efficient, one-pot synthesis of fosfomycin dialkyl esters from (R)-2-tosyloxypropanal 査読

Tadashi Hanaya, Yuichi Nakamura, Hiroshi Yamamoto

Heterocycles 74 983 - 989 2007年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

(R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.

Web of Science

researchmap

Improved syntheses of D-ribo- and 2-deoxy-D-ribofuranose phospho sugars from methyl β-D-ribopyranoside 査読

T. Hanaya, Y. Koga, H. Kawamoto, H. Yamamoto

Heterocycles 73 581 - 591 2007年

A new route for preparation of 2-deoxy-D-ribofuranose phospho sugar 査読

Heterocycles 72 411 - 420 2007年

Synthesis of 6- and 7-(1,2,3-trihydroxy-1,2-O-isopropylidenepropyl)pteridines and deoxygenation of their 3 '-hydroxy groups 査読

Tadashi Hanaya, Daisuke Takayama, Hiroshi Yamamoto

HETEROCYCLES 70 355 - 365 2006年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Treatment of 3,4-O-isopropylidene-L-threo-pentos-2-ulose (7) with 5,6-diamino-1,3-dimethyluracil (8) afforded 1,3-dimethyl-6-[(1R,2S)-1,2,3-trihydroxy-1,2-O-isopropylidenepropyl]lumazine (9a) and its 7-substituted isomer (9b). Deoxygenation of 3'-hydroxy groups of 9a,b was investigated in connection with a practical transformation of neopterin into biopterin.

Web of Science

researchmap

Differential effects of substituent and pressure on induced inclusion complexation of 6-O-alpha-D-glucosyl-beta-cyclodextrin with 4-substituted phenols 査読

Yoshimi Sueishi, Naoya Inazumi, Tatsuhiro Ide, Tadashi Hanaya

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY 54 201 - 208 2006年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The inclusion complexation of 6-O-alpha-D-glucosyl-beta-cyclodextrin (G-beta-CD), in which the glucosyl side chain is introduced to beta-CD, with various kinds of phenols was studied spectrophotometrically at high pressures. The characteristic effects of substituent and pressure were found for the inclusion complexation of G-beta-CD. The association constants K for the G-beta-CD inclusion complexation increased with an increase in the bulkiness of the 4-substituent groups in phenols. As the external pressure increases, the inclusion constants for the G-beta-CD complexation increased and the reaction volumes were estimated to be -3.8 to -19.4 cm(3) mol(-1) from their pressure dependences. From analysis of the effect of pressure on the inclusion complexation with G-beta-CD, the number of water molecules included in the G-beta-CD cavity in water was estimated. The number of water molecules repelled from the CD cavity plays an important role in the change in volume upon inclusion. In addition, the structures of the inclusion complexes of G-beta-CD with phenols have been established by 1D and 2D NMR measurements. Based on the results, we suggested that the ability of the G-beta-CD inclusion complexation is enhanced by the interaction between guest molecules and the glucosyl side chain of G-beta-CD.

DOI： 10.1007/s10847-005-7368-7

Web of Science

researchmap

An efficient synthesis of 2 '-O-(beta-D-glucopyranosyl)- and 2 '-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-biopterins 査読

T Hanaya, K Soranaka, K Harada, H Yamaguchi, R Suzuki, Y Endo, H Yamamoto, W Pfleiderer

Heterocycles 67 299 - 310 2006年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

N-2-(N,N-Dimethylaminomethylene)-3-[2-(4-nitrophenyl)ethyl]-1',2'-di-O-trimethylsilyl-L-biopterin (6) was prepared from L-biopterin in 5 steps. Glycosylation of 6 with 2,3,4,6-tetra-O-benzoyl-alpha-D-glucopyranosyl trichloroacetimidate (9) and 1,3,4,6-tetra-O-acetyl-2-phtalimido-beta-D-glucopyranose (10) respectively afforded the corresponding 2'-O-(beta-D-glucopyranosyl) derivatives (12b, 12c) as major products. Removal of protecting groups of 12c provided naturally occurring limipterin (2).

DOI： 10.3987/COM-05-S(T)28

Web of Science

researchmap

Synthesis of functionalized phospholane oxides and phosphorinane oxides from 1,4- and 1,5-di-O-mesyloxy compounds 査読

Tadashi Hanaya, Karsten Schurrle, Hiroshi Yamamoto

Heterocycles 69 ( 1 ) 283 - 294 2006年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Treatment of 1,4-di-0-mesyl-2,3-di-O-methyl-L-threitol (8b) with phenylphosphine in the presence of sodium hydride in DMSO, followed by the action of hydrogen peroxide, afforded 3,4-dimethoxy-1-phenylphospholane 1-oxide (7), while the same treatment of 1,5-di-O-mesyl-2,3,4-tri-O-methyl-mesoxylitol (11b) provided 2,3,4-trimethoxy-1-phenylphosphorinane 1-oxide (14).

Web of Science

researchmap

Novel preparation of a 2 '-O-acetyl-1 '-O-(4-methoxybenzyl)-L-biopterin derivative, a versatile precursor for a selective synthesis of L-biopterin glycosides 査読

Tadashi Hanaya, Hiroki Toyota, Hiroshi Yamamoto

SYNLETT 2075 - 2078 2006年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：GEORG THIEME VERLAG KG

L-Rhamnose was converted, over a 13-step-sequence, into 2'-O-acetyl-N-2-(N,N-dimethylaminomethylene)-1'-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]-L-biopterin, an appropriately protected precursor of 1'-O- and 2'-O-monoglycosyl-L-biopterin. Thus, the first selective synthesis of these L-biopterin glycosides was accomplished by treatment of the precursor with either DDQ or sodium methoxide, then with tetra-O-benzoyl-alpha-D-glucopyranosyl bromide in the presence of silver triflate and tetramethylurea, followed by removal of the remaining protecting groups.

DOI： 10.1055/s-2006-949620

Web of Science

researchmap

Synthesis of phospholane 1-oxide having oxygen functional groups from a 4-bromobutylphoshinate derivative 査読

T Hanaya, S Kawase, H Yamamoto

Heterocycles 66 251 - 261 2005年12月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Ethyl 4-bromo-2,3-dimethoxybutyl(phenyl)phosphinate (10a) was prepared from 2,3-di-0-methyl-L-threitol (12) in five steps. Reduction of 10a with sodium dihydrobis(2-methoxyethoxy)aluminate, followed by the action of hydrogen peroxide, afforded 3,4-dimethoxy-1-phenylphospholane I-oxide (3), while the reaction of 10a with magnesium in boiling THF resulted in the formation of ethyl 2-methoxy-3-butenyl(phenyl)phosphinate (26).

DOI： 10.3987/COM-05-S(K)15

Web of Science

researchmap

An efficient synthesis of methyl 1,3-O-isopropylidene-alpha-D-fructofuranoside and 2,3 : 5,6-di-O-isopropylidene-D-glucose dimethyl acetal derivatives from sucrose 査読

T Hanaya, N Sato, H Yamamoto

Carbohydr. Res. 340 2494 - 2501 2005年11月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI LTD

Acetalation of sucrose with 2,2-dimethoxypropane in 1,4-dioxane in the presence of p-toluenesulfonic acid, followed by acetylation, afforded methyl 4,6-di-O-acetyl-1,3-O-isopropylidene-alpha-D-fructofuranoside and 4-O-acetyl-2,3:5,6-di-O-isopropylidene-D-glucose dimethyl acetal as major products, while tosylation of the intermediate acetals provided methyl 6-O-tosyl-1,3-O-isopropytidene-alpha-D-fructofuranose. (C) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.carres.2005.07.023

Web of Science

researchmap

Effects of pressure on inclusion complexation of methylene blue with water-soluble p-sulfonatocalix[n]arenes 査読

Y Sueishi, N Inazumi, T Hanaya

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY 18 ( 5 ) 448 - 455 2005年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JOHN WILEY & SONS LTD

The effects of pressure were examined for the inclusion complexation of water-soluble p-sulfonated calix[n]arenes (Calix-Sn: n = 4, Calix-S4; n = 6, Calix-S6; n = 8, Calix-S8) with methylene blue (MB). A differential pressure effect was found in the inclusion equilibria of Calix-Sn. As the external pressure increases, the inclusion equilibrium of MB with Calix-S4 and Calix-S6 shifts to the dissociation side. However, with Calix-S8, the inclusion equilibrium shifts to the association side with increased pressure. From the pressure dependence of the inclusion equilibria of Calix-Sn, the reaction volumes, which are changes in volume accompanied by inclusion, were estimated as 32.1 cm(3) mol(-1) for Calix-S4, 30.1 cm(3) mol(-1) for Calix-S6 and -13.8 cm(3) mol(-1) for Calix-S8. In addition, the structures of the inclusion complexes of Calix-Sn with MB have been established by H-1 NMR measurements. Based on the results, the behavior of inclusion complexation with Calix-Sn is discussed. Copyright (c) 2004 John Wiley T Sons, Ltd.

DOI： 10.1002/poc.888

Web of Science

researchmap

　前のページ - 次のページ　

<花谷 正>

論文 - 花谷 正

<花谷　正>

論文 - 花谷　正