研究者詳細 - 石田　悠志

論文 - 石田　悠志

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Paediatric anaplastic large‐cell lymphoma with cardiac tamponade 査読

Takahiro Shiwaku, Kosuke Tamefusa, Hisashi Ishida, Kaori Fujiwara, Kana Washio, Hirokazu Tsukahara

2025年4月

Favorable outcomes of de novo advanced phases of pediatric chronic myeloid leukemia in the tyrosine kinase inhibitor era 査読

Toshihide Yoshikawa, Hisashi Ishida, Akihiro Watanabe, Yuki Yuza, Haruko Shima, Masaki Ito, Yukari Sakurai, Dai Keino, Takuya Ichimura, Keisuke Kato, Yuko Osugi, Shosuke Sunami, Kunihiro Shinoda, Toshihiko Imamura, Katsuyoshi Koh, Yuri Okimoto, Chikako Tono, Hiroyuki Shimada, Akihiko Tanizawa

International Journal of Hematology 2025年3月

Empowering pediatric, adolescent, and young adult patients with cancer utilizing generative AI chatbots to reduce psychological burden and enhance treatment engagement: a pilot study 査読

Joe Hasei, Mana Hanzawa, Akihito Nagano, Naoko Maeda, Shinichirou Yoshida, Makoto Endo, Nobuhiko Yokoyama, Motoharu Ochi, Hisashi Ishida, Hideki Katayama, Tomohiro Fujiwara, Eiji Nakata, Ryuichi Nakahara, Toshiyuki Kunisada, Hirokazu Tsukahara, Toshifumi Ozaki

Frontiers in Digital Health 7 2025年2月

Alectinib maintenance therapy following cord blood transplantation for relapsed pediatric anaplastic large cell lymphoma with central nervous system involvement 査読

Kosuke Tamefusa, Hisashi Ishida, Daisuke Miyahara, Takahiro Shiwaku, Motoharu Ochi, Kiichiro Kanamitsu, Kaori Fujiwara, Yasuhisa Tatebe, Kana Washio, Tomoyuki Akiyama, Hirokazu Tsukahara

Annals of Hematology 2024年11月

Letermovir at a Prophylactic Dose for Cytomegalovirus Infection in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Retrospective Study in Japan 査読

Yasuhisa Tatebe, Yohei Manabe, Yuta Tanaka, Takahiro Shiwaku, Motoharu Ochi, Kosuke Tamefusa, Hisashi Ishida, Kaori Fujiwara, Kana Washio, Hirofumi Hamano, Kiminaka Murakawa, Yoshito Zamami

Biological and Pharmaceutical Bulletin 47 ( 9 ) 1575 - 1582 2024年9月

Salvage hematopoietic cell transplantation for children with acute myeloid leukemia relapsed after first transplantation: a Japanese national registry study 査読

Hirotoshi Sakaguchi, Takashi Taga, Hisashi Ishida, Asahito Hama, Yasuhiro Okamoto, Hideki Sano, Maho Sato, Yuhki Koga, Katsuyoshi Koh, Fuminori Iwasaki, Nao Yoshida, Yuko Cho, Keiko Okada, Kentaro Watanabe, Akihiro Watanabe, Daiichiro Hasegawa, Maiko Noguchi, Yoshiko Hashii, Kimikazu Matsumoto, Ken Tabuchi, Daisuke Tomizawa, Yuichi Mitani, Soichi Adachi, Shotaro Iwamoto, Yuta Kawahara, Akira Shimada, Yasuko Kojima, Shinichi Tsujimoto, Takako Miyamura, Shohei Yamamoto, Ayako Yamamori, Masanori Yoshida

Bone Marrow Transplantation 2024年8月

Utilizing the Metaverse to Provide Innovative Psychosocial Support for Pediatric, Adolescent, and Young Adult Patients with Rare Cancer 査読

Joe Hasei, Hisashi Ishida, Hideki Katayama, Naoko Maeda, Akihito Nagano, Motoharu Ochi, Masako Okamura, Shintaro Iwata, Kunihiro Ikuta, Shinichirou Yoshida, Tomohiro Fujiwara, Eiji Nakata, Ryuichi Nakahara, Toshiyuki Kunisada, Toshifumi Ozaki

Cancers 16 ( 15 ) 2617 - 2617 2024年7月

Differential impact of asparaginase discontinuation on outcomes of children with T‐cell acute lymphoblastic leukemia and T‐cell lymphoblastic lymphoma 査読

Hisashi Ishida, Toshihiko Imamura, Ryoji Kobayashi, Yoshiko Hashii, Takao Deguchi, Takako Miyamura, Megumi Oda, Masaki Yamamoto, Keiko Okada, Hideki Sano, Katsuyoshi Koh, Yuki Yuza, Kenichiro Watanabe, Noriyuki Nishimura, Tetsuya Takimoto, Akiko Moriya‐Saito, Masahiro Sekimizu, Souichi Suenobu, Shosuke Sunami, Keizo Horibe

Cancer Medicine 13 ( 12 ) 2024年6月

Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells. 査読国際誌

Joana Carrelha, Stefania Mazzi, Axel Winroth, Michael Hagemann-Jensen, Christoph Ziegenhain, Kari Högstrand, Masafumi Seki, Margs S Brennan, Madeleine Lehander, Bishan Wu, Yiran Meng, Ellen Markljung, Ruggiero Norfo, Hisashi Ishida, Karin Belander Strålin, Francesca Grasso, Christina Simoglou Karali, Affaf Aliouat, Amy Hillen, Edwin Chari, Kimberly Siletti, Supat Thongjuea, Adam J Mead, Sten Linnarsson, Claus Nerlov, Rickard Sandberg, Tetsuichi Yoshizato, Petter S Woll, Sten Eirik W Jacobsen

Nature Immunology 25 ( 6 ) 1007 - 1019 2024年6月

Delayed diagnostic interval and survival outcomes in pediatric leukemia: A single‐center, retrospective study 査読

Kosuke Tamefusa, Motoharu Ochi, Hisashi Ishida, Takahiro Shiwaku, Kiichiro Kanamitsu, Kaori Fujiwara, Yasuhisa Tatebe, Naomi Matsumoto, Kana Washio, Hirokazu Tsukahara

European Journal of Haematology 112 ( 5 ) 714 - 722 2024年5月

A higher CD34 + cell dose correlates with better event-free survival after KIR-ligand mismatched cord blood transplantation for childhood acute myeloid leukemia 査読

Hisashi Ishida, Yuta Kawahara, Daisuke Tomizawa, Yasuhiro Okamoto, Asahito Hama, Yuko Cho, Katsuyoshi Koh, Yuhki Koga, Nao Yoshida, Maho Sato, Kiminori Terui, Naoyuki Miyagawa, Akihiro Watanabe, Junko Takita, Ryoji Kobayashi, Masaki Yamamoto, Kenichiro Watanabe, Keiko Okada, Koji Kato, Kimikazu Matsumoto, Moeko Hino, Ken Tabuchi, Hirotoshi Sakaguchi

Journal of Hematology & Oncology 17 ( 24 ) 2024年4月

Reduced-intensity allogenic transplantation for children and adolescents with Philadelphia chromosome-positive acute lymphoblastic leukemia 査読

Hisashi Ishida, Yuki Arakawa, Daiichiro Hasegawa, Ikuya Usami, Yoshiko Hashii, Yasuyuki Arai, Satoshi Nishiwaki, Dai Keino, Keisuke Kato, Maho Sato, Nao Yoshida, Yukiyasu Ozawa, Keiko Okada, Moe Hidaka, Yuki Yuza, Masatsugu Tanaka, Kenichiro Watanabe, Junko Takita, Yoshiyuki Kosaka, Naoto Fujita, Junji Tanaka, Atsushi Sato, Yoshiko Atsuta, Toshihiko Imamura

Annals of Hematology 103 ( 3 ) 843 - 854 2024年

造血細胞移植後の肝障害の鑑別にMRIが有用であった輸血後鉄過剰症の2小児例査読

鷲尾佳奈, 塩飽孝宏, 爲房宏輔, 越智元春, 石田悠志, 金光喜一郎, 藤原かおり, 塚原宏一

日本輸血細胞治療学会誌 69 ( 5 ) 605 - 609 2023年10月

記述言語：日本語出版者・発行元：一般社団法人日本輸血・細胞治療学会

小児がん患者における輸血後鉄過剰症については，海外からは報告が散見される．成人と同様，白血病等における同種造血細胞移植患者において，移植前の血清フェリチン値と合併症の相関等が議論されているが，日本国内からはまだまとまった報告はない．我々は，肝障害を来し，輸血後鉄過剰症と肝移植片対宿主病（GVHD）との鑑別に磁気共鳴画像（MRI）が有用であった2例を経験した．2例とも急性骨髄性白血病であり，肝GVHDとして免疫抑制療法等を行ったにもかかわらず遷延する肝障害を呈していた．高フェリチン血症を認めたためMRI撮像したところ，高度鉄沈着を示唆する所見を呈した．輸血後鉄過剰症として鉄キレート療法を行って肝障害が改善した．小児がん患者において，骨髄抑制期間が長く頻回の輸血を要するような症例では，急性期に臓器障害を伴う輸血後鉄過剰症を示す可能性があるが，治療介入の指針や時期については明らかになっていない．今後日本国内でも大規模な調査が必要と思われる．

DOI： 10.3925/jjtc.69.605

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A Boy Safely Treated with Tyrosine Kinase Inhibitors for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Osteolysis. 査読

Takahiro Shiwaku, Hisashi Ishida, Yasuhisa Tatebe, Kosuke Tamefusa, Motoharu Ochi, Kaori Fujiwara, Toshihide Kubo, Eiji Nakata, Kana Washio, Hirokazu Tsukahara

Acta medica Okayama 77 ( 4 ) 439 - 442 2023年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

A three-year-old boy with Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia (Ph+ALL) presented with an osteolytic lesion in his right upper arm. Tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib are an essential component throughout the course of treatment for Ph+ALL. However, TKIs are reported to affect the bone metabolism. In the treatment course of the current patient, the osteolytic lesion quickly improved despite the continuous use of TKIs, even during the concomitant use of corticosteroids. This suggests that TKIs can be safely given with concomitant corticosteroids to children with Ph+ALL, even when osteolytic lesions are present.

DOI： 10.18926/AMO/65757

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Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant 査読

Hisashi Ishida, Shin-ichi Tsujimoto, Daisuke Hasegawa, Hirotoshi Sakaguchi, Shohei Yamamoto, Masakatsu Yanagimachi, Katsuyoshi Koh, Akihiro Watanabe, Asahito Hama, Yuko Cho, Kenichiro Watanabe, Maiko Noguchi, Masanobu Takeuchi, Junko Takita, Kana Washio, Keisuke Kato, Takashi Koike, Yoshiko Hashii, Ken Tabuchi, Moeko Hino, Yoshiko Atsuta, Yasuhiro Okamoto

Haematologica 109 ( 1 ) 312 - 317 2023年7月

Outcome of hematopoietic stem cell transplantation in pediatric patients with acute lymphoblastic leukemia not in remission enrolled in JACLS ALL-02. 査読

Mio Yano, Hisashi Ishida, Junichi Hara, Hiroshi Kawaguchi, Etsuro Ito, Akiko Moriya-Saito, Yoshiko Hashii, Takao Deguchi, Takako Miyamura, Atsushi Sato, Hiroki Hori, Keizo Horibe, Toshihiko Imamura

International journal of hematology 118 ( 3 ) 364 - 373 2023年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Hematopoietic stem cell transplantation (HSCT) is only indicated for acute lymphoblastic leukemia (ALL) patients for whom other treatments are unlikely to be curative. However, outcomes of patients not in complete remission (CR) at HSCT remain very poor. To improve the outcomes of patients receiving HSCT, it is important to obtain detailed clinical information about patients with ALL receiving HSCT in CR and not in CR. Patients enrolled in the Japan Association of Childhood Leukemia Study ALL-02 who underwent HSCT and were not in CR (non-CR patients, n = 55) were examined. The 1-year overall survival (OS) rate of non-CR patients was 27.3%. Compared with CR patients, non-CR patients experienced very early and early relapse significantly more frequently and had poorer prognostic factors. Most interestingly, high hyperdiploid (HHD) patients showed an excellent 1-year OS of 80%. In addition, long-term survival among surviving HHD patients was longer than 5 years. All eight patients who survived after undergoing HSCT while not in CR were younger than 10 years at initial diagnosis and were negative for central nervous system involvement. While limited, these results suggest that a subset of patients may benefit from HSCT while not in CR.

DOI： 10.1007/s12185-023-03626-7

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Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era. 査読国際誌

Hisashi Ishida, Hiroyuki Shimada, Akihiko Tanizawa, Yutaka Shimazu, Takayoshi Tachibana, Noriko Doki, Takahide Ara, Yayoi Matsuo, Miho Nara, Tomomi Toubai, Kazuko Ino, Hirohisa Nakamae, Keisuke Kato, Koji Kato, Atsushi Sato, Moeko Hino, Kimikazu Matsumoto, Yoshiko Atsuta, Masahiro Yasui, Tokiko Nagamura-Inoue

American journal of hematology 98 ( 8 ) E200 - E203 2023年5月

Three Cases of Down Syndrome with Transient Abnormal Myelopoiesis who Underwent Liver Biopsy before Induction of Low-Dose Cytarabine. 査読

Kana Washio, Kosuke Tamefusa, Motoharu Ochi, Kiichiro Kanamitsu, Hisashi Ishida, Kaori Fujiwara, Kenji Nishida, Kei Tamai, Yosuke Washio, Junko Yoshimoto, Takuo Noda, Hirokazu Tsukahara

Acta medica Okayama 77 ( 2 ) 215 - 220 2023年4月

記述言語：英語

Among patients with transient abnormal myelopoiesis (TAM) associated with Down syndrome, approximately 20% die within 6 months from multiorgan failure, especially liver fibrosis. We experienced three children with TAM who had low white blood cell counts but increased bilirubin levels. Here, we discuss the detailed clinical courses of these patients, including the pathological findings of liver biopsies. Our cases, together with previous literature, suggest that liver biopsy can be performed safely and provides useful information, especially regarding disease activities, and that low-dose cytarabine is a reasonable option to prevent early death in TAM patients with liver dysfunction.

DOI： 10.18926/AMO/65153

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Impact of asparaginase discontinuation on outcomes of children with acute lymphoblastic leukaemia receiving the Japan Association of Childhood Leukaemia Study ALL-02 protocol. 査読国際誌

Hisashi Ishida, Toshihiko Imamura, Yasuhisa Tatebe, Takashi Ishihara, Kimiyoshi Sakaguchi, Souichi Suenobu, Atsushi Sato, Yoshiko Hashii, Takao Deguchi, Yoshihiro Takahashi, Daiichiro Hasegawa, Takako Miyamura, Akihiro Iguchi, Koji Kato, Akiko Saito-Moriya, Junichi Hara, Keizo Horibe

British journal of haematology 201 ( 6 ) 1200 - 1208 2023年3月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Asparaginase is an essential drug for acute lymphoblastic leukaemia (ALL) treatment, but has several side effects, and its discontinuation often compromises patient outcomes. In the prospective Japan Association of Childhood Leukaemia Study ALL-02 protocol, two major changes were made: (1) additional chemotherapies to compensate for the reduction of treatment intensity when asparaginase was discontinued and (2) more intensive concomitant corticosteroid administration, relative to our previous ALL-97 protocol. In ALL-02 study, 1192 patients were included and L-asparaginase was discontinued for 88 (7.4%). Discontinuation due to allergy was markedly decreased relative to the ALL-97 protocol (2.3% vs 15.4%). Event-free survival (EFS) among patients with T-ALL was compromised when L-asparaginase was discontinued, as well as among patients with high-risk B-cell ALL, especially when discontinued before maintenance therapy. Moreover, multivariate analysis identified discontinuation of L-asparaginase as an independent poor prognostic factor for EFS. In the current study, additional chemotherapies failed to fully compensate for L-asparaginase discontinuation, illustrating the difficulty of replacing asparaginase with other classes of drugs, although this study was not designed to evaluate the effect of these modifications. Concomitant intensive corticosteroid treatment may help to reduce allergy to asparaginase. These results will assist in further optimization of asparaginase use.

DOI： 10.1111/bjh.18745

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Posttransplant gilteritinib maintenance therapy for pediatric acute myeloid leukemia with myelodysplasia-related changes with FLT3-internal tandem duplication. 査読国際誌

Kosuke Tamefusa, Hisashi Ishida, Kiichiro Kanamitsu, Motoharu Ochi, Kaori Fujiwara, Yasuhisa Tatebe, Michinori Aoe, Seishiro Nodomi, Kana Washio

Pediatric blood & cancer 70 ( 4 ) e30108 2022年12月

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