2025/04/04 更新

写真a

マツオカ　ダイキ
松岡　大貴
MATSUOKA DAIKI
所属
学術研究院医療開発領域 助教
職名
助教
外部リンク

学位

  • 歯学博士 （ 2024年3月   岡山大学大学院医歯薬学総合研究科 ）

所属学協会

  • International Association for Dental Research (IADR)

    2024年1月 - 現在

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  • 岡山歯学会

    2023年9月 - 現在

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  • International Association of Paediatric Dentistry (IAPD)

    2022年12月 - 現在

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  • 日本小児歯科学会

    2020年 - 現在

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委員歴

  • バイオバンク連絡専門委員  

    2024年5月 - 現在   

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  • 特定臨床研究管理担当者  

    2024年5月 - 現在   

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論文

  • Relationship Between the Presence of Red Complex Species and the Distribution of Other Oral Bacteria, Including Major Periodontal Pathogens in Older Japanese Individuals. 国際誌

    Mariko Kametani, Yasuyuki Nagasawa, Momoko Usuda, Ami Kaneki, Masashi Ogawa, Kensaku Shojima, Hiromitsu Yamazaki, Kana Tokumoto, Daiki Matsuoka, Kana Suehara, Yuto Suehiro, Tatsuya Akitomo, Chieko Mitsuhata, Taro Misaki, Seigo Ito, Shuhei Naka, Michiyo Matsumoto-Nakano, Kazuhiko Nakano, Hiromitsu Kishimoto, Ken Shinmura, Ryota Nomura

    International journal of molecular sciences   25 ( 22 )   2024年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Red complex bacteria (Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia) have high virulence in periodontal disease. In the present study, we aimed to elucidate the detailed symbiotic relationships between the red complex and other oral bacteria in older Japanese individuals. Polymerase chain reaction was performed using dental plaque from 116 subjects and specific primers for ten periodontal pathogens. The detection rate of Prevotella intermedia and Capnocytophaga sputigena was significantly higher in P. gingivalis-positive subjects than in P. gingivalis-negative subjects (p < 0.05). The detection rate of Campylobacter rectus, Prevotella nigrescens, Capnocytophaga ochracea, and Eikenella corrodens was significantly higher in T. forsythia-positive subjects than in T. forsythia-negative subjects (p < 0.01). In a comprehensive analysis of oral microbiomes, three red complex species-positive subjects had significantly higher α-diversity than only P. gingivalis-positive subjects (p < 0.05) and had significantly lower β-diversity than only T. forsythia-positive subjects (p < 0.01). In the taxonomy analysis, Porphyromonas was significantly higher in three red complex species-positive subjects than in only P. gingivalis-positive and only T. forsythia-positive subjects (p < 0.01). These results suggest that each red complex species forms a unique oral microbiome and individuals positive for all red complex bacteria may harbor oral bacteria that confer a significant advantage in developing periodontal disease.

    DOI： 10.3390/ijms252212243

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  • Contribution of collagen-binding protein Cnm of Streptococcus mutans to induced IgA nephropathy-like nephritis in rats. 国際誌

    Shuhei Naka, Daiki Matsuoka, Taro Misaki, Yasuyuki Nagasawa, Seigo Ito, Ryota Nomura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano

    Communications biology   7 ( 1 )   1141 - 1141   2024年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    IgA nephropathy (IgAN), the most common primary glomerulonephritis, is considered an intractable disease with unknown pathogenic factors. In our previous study, Streptococcus mutans, the major causative bacteria of dental caries, which expresses Cnm, was related to the induction of IgAN-like nephritis. In the present study, the Cnm-positive S. mutans parental strain, a Cnm-defective isogenic mutant strain, its complementation strain, and recombinant Cnm (rCnm) protein were administered intravenously to Sprague Dawley rats, and the condition of their kidneys was evaluated focusing on the pathogenicity of Cnm. Rats treated with parental and complement bacterial strains and rCnm protein developed IgAN-like nephritis with mesangial proliferation and IgA and C3 mesangial deposition. Scanning immunoelectron microscopy revealed that rCnm was present in the electron-dense deposition area of the mesangial region in the rCnm protein group. These results demonstrated that the Cnm protein itself is an important factor in the induction of IgAN in rats.

    DOI： 10.1038/s42003-024-06826-x

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  • IgA腎症患者と習慣性扁桃炎患者の摘出扁桃における歯周病菌の検出率の比較

    長澤 康行, 野村 良太, 三崎 太郎, 伊藤 誓悟, 山崎 博充, 庄嶋 健作, 松岡 大貴, 仲 周平, 仲野 道代, 新村 健, 仲野 和彦

    日本腎臓学会誌   66 ( 4 )   591 - 591   2024年6月

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    記述言語：日本語   出版者・発行元：(一社)日本腎臓学会  

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  • Eruption cyst caused by congenital tooth in low birth weight infant

    Eri Yoshida, Kana Goto, Daiki Matsuoka, Yukiko Miyai, Haruka Asaumi, Keiko Tabata, Shuhei Naka, Michiyo Matsumoto-Nakano

    Pediatric Dental Journal   34 ( 1 )   42 - 45   2024年4月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.pdj.2023.06.004

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  • Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.

    Seigo Ito, Taro Misaki, Yasuyuki Nagasawa, Ryota Nomura, Shuhei Naka, Akiko Fukunaga, Daiki Matsuoka, Saaya Matayoshi, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

    Clinical and experimental nephrology   28 ( 3 )   192 - 200   2024年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: The relationship between the major periodontal bacteria, Porphyromonas gingivalis, and the pathogenesis of IgA nephropathy (IgAN)-particularly with respect to galactose-deficient IgA1 (Gd-IgA1)-has not been fully elucidated. METHODS: Saliva samples from 30 IgAN patients and 44 patients with chronic kidney disease (CKD) were subjected to analysis of P. gingivalis status via polymerase chain reaction using a set of P. gingivalis-specific primers. The associations between P. gingivalis presence and clinical parameters, including plasma Gd-IgA1, were analyzed in each group. RESULTS: Compared with the CKD group, the IgAN group demonstrated significantly higher plasma Gd-IgA1 levels (p < 0.05). Compared with the P. gingivalis-negative subgroup, the P. gingivalis-positive subgroup exhibited significantly higher plasma Gd-IgA1 levels in both IgAN and CKD patients (p < 0.05). Additionally, among IgAN patients, the P. gingivalis-positive subgroup displayed significantly higher plasma Gd-IgA1 and urine protein levels, compared with the P. gingivalis-negative subgroup (p < 0.05). With respect to renal biopsy findings, the frequencies of segmental glomerulosclerosis and tubular atrophy/interstitial fibrosis were significantly greater in the P. gingivalis-positive subgroup than in the P. gingivalis-negative subgroup, according to the Oxford classification of IgAN (p < 0.05). CONCLUSION: Our findings suggest an association between the presence of P. gingivalis in the oral cavity and the pathogenesis of IgAN, mediated by increased levels of Gd-IgA1.

    DOI： 10.1007/s10157-023-02411-4

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  • Diagnosis of maxillary lateral incisor dens invaginatus and therapeutic approach

    Setsuyo Morimoto, Kana Goto, Asaumi Haruka, Tabata Keiko, Daiki Matsuoka, Shuhei Naka, Michiyo Matsumoto-Nakano

    Pediatric Dental Journal   33 ( 3 )   216 - 222   2023年12月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Elsevier BV  

    DOI： 10.1016/j.pdj.2023.06.003

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  • 口腔内のcnm遺伝子陽性S.mutansとIgA腎症患者の糖鎖異常IgA沈着の関連性 査読

    三崎 太郎, 仲 周平, 鈴木 仁, 李 明峰, 青木 良輔, 長澤 康行, 松岡 大貴, 伊藤 誓悟, 野村 良太, 仲野 道代, 鈴木 祐介, 仲野 和彦

    日本腎臓学会誌   65 ( 3 )   271 - 271   2023年5月

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    記述言語：日本語   出版者・発行元：(一社)日本腎臓学会  

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  • Simultaneous Presence of Campylobacter rectus and Cnm-Positive Streptococcus mutans in the Oral Cavity Is Associated with Renal Dysfunction in IgA Nephropathy Patients: 5-Year Follow-Up Analysis. 国際誌

    Taro Misaki, Shuhei Naka, Yasuyuki Nagasawa, Daiki Matsuoka, Seigo Ito, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

    Nephron   147 ( 3-4 )   134 - 143   2023年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: The simultaneous presence of Streptococcus mutans expressing the Cnm protein encoded by cnm (i.e., cnm-positive S. mutans) and Campylobacter rectus in the oral cavity has been associated with proteinuria in patients with IgA nephropathy (IgAN). OBJECTIVES: The present study evaluated the relationship between renal function and oral bacteria in patients with IgAN over 5 years of follow-up. METHODS: The presence of C. rectus and cnm-positive S. mutans in saliva samples of 117 patients with IgAN was initially evaluated by polymerase chain reaction. Patients were then divided into four groups according to the results of C. rectus and cnm-positive S. mutans detection: group A: C. rectus (-), cnm-positive S. mutans (-); group B: C. rectus (+), cnm-positive S. mutans (-); group C: C. rectus (-), cnm-positive S. mutans (+); and group D: C. rectus (+), cnm-positive S. mutans (+). Clinical characteristics were prospectively followed for 5 years. RESULTS: Serum creatinine levels were significantly higher in group D than in group A over 5 years of follow-up. Additionally, the proportion of patients with an estimated glomerular filtration rate <45 mL/min increased over time; it was significantly greater in group D than in group A over 5 years of follow-up. CONCLUSION: These results suggest that the simultaneous presence of C. rectus and cnm-positive S. mutans in the oral cavity is associated with renal dysfunction in IgAN patients.

    DOI： 10.1159/000525511

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  • cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy. 国際誌

    Taro Misaki, Shuhei Naka, Hitoshi Suzuki, Mingfeng Lee, Ryosuke Aoki, Yasuyuki Nagasawa, Daiki Matsuoka, Seigo Ito, Ryota Nomura, Michiyo Matsumoto-Nakano, Yusuke Suzuki, Kazuhiko Nakano

    PloS one   18 ( 3 )   e0282367   2023年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The presence of Streptococcus mutans expressing Cnm protein encoded by cnm (cnm-positive S. mutans) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm-positive S. mutans is involved in the pathogenesis of IgAN remains unclear. The present study evaluated glomerular galactose-deficient IgA1 (Gd-IgA1) to clarify the association between the presence of cnm-positive S. mutans and glomerular Gd-IgA1 in patients with IgAN. The presence of S. mutans and cnm-positive S. mutans was evaluated by polymerase chain reaction in saliva specimens from 74 patients with IgAN or IgA vasculitis. Immunofluorescent staining of IgA and Gd-IgA1 using KM55 antibody in clinical glomerular tissues was then performed. There was no significant association between the glomerular staining intensity of IgA and the positive rate of S. mutans. However, there was a significant association between the glomerular staining intensity of IgA and the positive rate of cnm-positive S. mutans (P < 0.05). There was also a significant association between the glomerular staining intensity of Gd-IgA1 (KM55) and the positive rate of cnm-positive S. mutans (P < 0.05). The glomerular staining intensity of Gd-IgA1 (KM55) was not associated with the positive rate of S. mutans. These results suggest that cnm-positive S. mutans in the oral cavity is associated with the pathogenesis of Gd-IgA1 in patients with IgAN.

    DOI： 10.1371/journal.pone.0282367

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  • Cnm of Streptococcus mutans is important for cell surface structure and membrane permeability. 国際誌

    Shuhei Naka, Daiki Matsuoka, Kana Goto, Taro Misaki, Yasuyuki Nagasawa, Seigo Ito, Ryota Nomura, Kazuhiko Nakano, Michiyo Matsumoto-Nakano

    Frontiers in cellular and infection microbiology   12   994014 - 994014   2022年

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Streptococcus mutans, a Gram-positive facultative anaerobic bacterium, is a major pathogen of dental caries. The protein Cnm of S. mutans is involved in collagen binding, but its other biological functions are unknown. In this study, a Cnm-deficient isogenic mutant and a complementation strain were generated from a Cnm-positive S. mutans strain to help determine the properties of Cnm. Initially, comparison of the cell surface structure was performed by electron microscopy, which demonstrated that Cnm appears to be localized on the cell surface and associated with a protruding cell surface structure. Deep RNA sequencing of the strains revealed that the defect in Cnm caused upregulated expression of many genes related to ABC transporters and cell-surface proteins, while a few genes were downregulated. The amount of biofilm formed by the Cnm-defective strain increased compared with the parental and complemented strains, but the biofilm structure was thinner because of elevated expression of genes encoding glucan synthesis enzymes, leading to increased production of extracellular polysaccharides. Particular antibiotics, including bacitracin and chloramphenicol, had a lower minimum inhibitory concentration for the Cnm-defective strain than particular antibiotics, including bacitracin and chloramphenicol, compared with the parental and complemented strains. Our results suggest that S. mutans Cnm is located on the cell surface, gives rise to the observed protruding cell surface, and is associated with several biological properties related to membrane permeability.

    DOI： 10.3389/fcimb.2022.994014

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  • Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries. 国際誌

    Shuhei Naka, Kaoruko Wato, Taro Misaki, Seigo Ito, Daiki Matsuoka, Yasuyuki Nagasawa, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

    Scientific reports   11 ( 1 )   5784 - 5784   2021年3月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    The mechanisms underlying immunoglobulin A nephropathy (IgAN), the most common chronic form of primary glomerulonephritis, remain poorly understood. Streptococcus mutans, a Gram-positive facultatively anaerobic oral bacterium, is a common cause of dental caries. In previous studies, S. mutans isolates that express Cnm protein on their cell surface were frequently detected in IgAN patients. In the present study, inoculation of Cnm-positive S. mutans in the oral cavities of 2-week-old specific-pathogen free Sprague-Dawley rats fed a high-sucrose diet for 32 weeks produced severe dental caries in all rats. Immunohistochemical analyses of the kidneys using IgA- and complement C3-specific antibodies revealed positive staining in the mesangial region. Scanning electron microscopy revealed a wide distribution of electron dense deposits in the mesangial region and periodic acid-Schiff staining demonstrated prominent proliferation of mesangial cells and mesangial matrix. These results suggest that IgAN-like glomerulonephritis was induced in rats with severe dental caries by Cnm-positive S. mutans.

    DOI： 10.1038/s41598-021-85196-4

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MISC

  • う蝕原性細菌cnm陽性Streptococcus mutansは扁桃を介してIgA腎症を増悪させる

    伊藤 誓悟, 三崎 太郎, 長澤 康行, 松岡 大貴, 仲 周平, 野村 良太, 仲野 道代, 仲野 和彦

    日本腎臓学会誌   66 ( 4 )   637 - 637   2024年6月

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    記述言語：日本語   出版者・発行元：(一社)日本腎臓学会  

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  • IgA腎症患者と習慣性扁桃炎患者の摘出扁桃における歯周病菌の検出率の比較

    長澤 康行, 野村 良太, 三崎 太郎, 伊藤 誓悟, 山崎 博充, 庄嶋 健作, 松岡 大貴, 仲 周平, 仲野 道代, 新村 健, 仲野 和彦

    日本腎臓学会誌   66 ( 4 )   591 - 591   2024年6月

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    記述言語：日本語   出版者・発行元：(一社)日本腎臓学会  

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  • ラットIgA腎症モデルにおける各種臓器での遺伝子発現の網羅的解析

    松岡 大貴, 末原 佳奈, 仲 周平, 野村 良太, 仲野 和彦, 仲野 道代

    小児歯科学雑誌   62 ( 大会抄録号 )   153 - 153   2024年4月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

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  • コラーゲン結合タンパクCnmとヒト免疫グロブリンの結合に関する分子生物学的検討

    末原 佳奈, 松岡 大貴, 仲 周平, 野村 良太, 仲野 和彦, 仲野 道代, 三崎 太郎, 長澤 康行, 伊藤 誓悟

    小児歯科学雑誌   62 ( 大会抄録号 )   149 - 149   2024年4月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

    J-GLOBAL

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  • う蝕原性細菌cnm陽性Streptococcus mutansは扁桃を介してIgA腎症を増悪させる

    伊藤誓悟, 三崎太郎, 長澤康行, 松岡大貴, 仲周平, 野村良太, 仲野道代, 仲野和彦

    日本腎臓学会誌(Web)   66 ( 4 )   2024年

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  • 口腔内のcnm遺伝子陽性S.mutansとIgA腎症患者の糖鎖異常IgA沈着の関連性

    三崎 太郎, 仲 周平, 鈴木 仁, 李 明峰, 青木 良輔, 長澤 康行, 松岡 大貴, 伊藤 誓悟, 野村 良太, 仲野 道代, 鈴木 祐介, 仲野 和彦

    日本腎臓学会誌   65 ( 3 )   271 - 271   2023年5月

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    記述言語：日本語   出版者・発行元：(一社)日本腎臓学会  

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  • コラーゲン結合タンパクCumとヒトIgAの結合に関する分子生物学的検討

    松岡 大貴, 仲 周平, 後藤 花奈, 野村 良太, 仲野 和彦, 仲野 道代

    小児歯科学雑誌   61 ( 大会抄録号 )   135 - 135   2023年4月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

    J-GLOBAL

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  • Streptococcus mutansのコラーゲン結合タンパクCnmの構造解析

    松岡 大貴, 仲 周平, 稲葉 裕明, 仲野 道代

    小児歯科学雑誌   61 ( 地方会抄録号 )   66 - 66   2023年2月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

    J-GLOBAL

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  • 口腔内のcnm遺伝子陽性S.mutansとIgA腎症患者の糖鎖異常IgA沈着の関連性

    三崎太郎, 仲周平, 鈴木仁, 李明峰, 青木良輔, 長澤康行, 松岡大貴, 伊藤誓悟, 野村良太, 仲野道代, 鈴木祐介, 仲野和彦

    日本腎臓学会誌(Web)   65 ( 3 )   2023年

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  • Streptococcus mutansコラーゲン結合タンパクCnmの構造および機能の検討

    松岡 大貴, 仲 周平, 後藤 花奈, 稲葉 裕明, 仲野 道代

    岡山歯学会雑誌   41 ( 2 )   62 - 62   2022年12月

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    記述言語：日本語   出版者・発行元：岡山歯学会  

    J-GLOBAL

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  • Streptococcus mutansコラーゲン結合タンパクCnmの病原性に関する検討

    松岡 大貴, 仲 周平, 後藤 花奈, 野村 良太, 仲野 和彦, 仲野 道代

    小児歯科学雑誌   60 ( 大会抄録号 )   215 - 215   2022年3月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

    J-GLOBAL

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  • IgA腎症患者口腔由来Cnm陽性Streptococcus mutansの分子生物学的解析

    松岡 大貴, 仲 周平, 仲野 道代

    小児歯科学雑誌   60 ( 地方会抄録号 )   55 - 55   2022年2月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

    J-GLOBAL

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  • Streptococcus mutansコラーゲン結合タンパクのIgA腎症発症メカニズムへの関与

    松岡 大貴, 仲 周平, 後藤 花奈, 和唐 薫子, 野村 良太, 仲野 和彦, 仲野 道代, 三崎 太郎, 長澤 康行, 伊藤 誓悟

    小児歯科学雑誌   59 ( 大会抄録(Web開催)号 )   110 - 110   2021年5月

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    記述言語：日本語   出版者・発行元：(公社)日本小児歯科学会  

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講演・口頭発表等

  • ラット動物モデルにおける Streptococcus mutans コラーゲン結合タンパク Cnm の IgA 腎症発症メカニズムへの関与

    松岡大貴

    第 91 回 ARCOCS セミナー  2024年10月 

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  • コラーゲン結合タンパク Cnm とヒト IgA の結合に関する分子生物学的検討

    松岡大貴

    第61回日本小児歯科学会大会  2023年5月 

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  • Streptococcus mutans コラーゲン結合タンパク Cnm の構造および機能の検討

    松岡大貴

    第43回岡山歯学会総会学術大会  2022年12月 

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