2025/02/22 更新

写真a

オノ サワコ
小野 早和子
ONO Sawako
所属
医歯薬学域 助教
職名
助教
外部リンク

学位

  • 博士(歯学)(岡山大学) ( 2017年3月 )

 

論文

  • High Prevalence of MYD88 and CD79B Mutations in Primary Sinonasal Diffuse Large B-Cell Lymphoma: Identification of an MCD-like Subtype. 国際誌

    Fangli Peng, Takuro Igawa, Tomohiro Urata, Hiroki Kobayashi, Tetsuya Isoda, Sawako Ono, Takehiro Tanaka, Daisuke Ennisshi, Yoshinobu Maeda, Hidetaka Yamamoto

    The American journal of surgical pathology   2024年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Primary sinonasal diffuse large B-cell lymphoma (PSDLBCL) is a rare aggressive lymphoma. Recently, genetic classification using Next Generation Sequencing (NGS) demonstrated that PSDLBCL largely consists of the MCD genotype, which has a poor prognosis mainly driven by MYD88 L265P and CD79B gene abnormalities. This study investigated the prevalence and clinicopathological significance of MYD88 L265P and CD79B Y196 mutations using droplet digital PCR in 55 patients with PSDLBCL, as well as the translocation of BCL2/BCL6/c-Myc with FISH. We found mutations in MYD88 L265P (29/55, 52.7%) and CD79B Y196 (20/55, 36.4%). The MCD-like subtype, defined by the mutation of MYD88 and/or CD79B, was found in 32 out of 55 cases (58.2%). This subtype largely consists of non-GCB type (31/32, 96.9%; P<0.01) and double-expressor cases (20/32, 62.5%; P=0.01) compared with the MYD88/CD79B co-wild type, with BCL6 translocation in a small subset (2/32, 6.3%) and no translocations of BCL2 (0/32) or c-Myc (0/32). The MCD-like subtype tended to relapse in specific sites such as the central nervous system, testis, and/or skin compared with the co-wild type (P=0.03), showing poorer outcomes in overall survival (P=0.02) and progression-free survival (P=0.01). In conclusion, our study highlights a high prevalence of MYD88 and CD79B mutations in PSDLBCL, identifying an aggressive MCD-like subtype with a distinct relapse pattern. This molecular subclassification can be helpful for both prognostic prediction and therapeutic strategy in patients with PSDLBCL.

    DOI: 10.1097/PAS.0000000000002329

    PubMed

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  • Cryptococcal prostatitis in an immunocompromised patient with tocilizumab and glucocorticoid therapy: A case report. 国際誌

    Kohei Oguni, Shinnosuke Fukushima, Hideharu Hagiya, Atsushi Kato, Atsuhito Suyama, Takehiro Iwata, Yoshia Miyawaki, Sawako Ono, Koji Iio, Fumio Otsuka

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2024年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cryptococcus prostatitis is an uncommon manifestation of cryptococcal infection that occurs mostly in immunocompromised patients. Tocilizumab, an anti-interleukin-6 receptor monoclonal antibody, has been associated with an increased risk of cryptococcal infections. However, there have been no documented cases of cryptococcal prostatitis in patients receiving tocilizumab therapy. We report a case of cryptococcal prostatitis in a 72-year-old man treated with glucocorticoids and tocilizumab for giant cell arteritis and granulomatosis with polyangiitis. The patient presented dysuria and his serum level of prostate-specific antigen was elevated. Magnetic resonance imaging revealed a prostate mass, and a prostate biopsy was performed, leading to a pathologic diagnosis of cryptococcal prostatitis. Fungal cultures for blood and urine were negative, while the cryptococcal antigen for both serum and urine showed positive results. There were no particular findings in the pulmonary and central nervous systems. The patient was successfully treated with oral fluconazole (400 mg/day) and was discharged. Although cryptococcal prostatitis is a rare entity, clinicians should note that an immunosuppressed patient may develop such a difficult-to-diagnose disease.

    DOI: 10.1016/j.jiac.2024.08.009

    PubMed

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  • Pneumocephalus with Inverted Papilloma in the Frontoethmoidal Sinus: Case Report and Literature Review.

    Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Sawako Ono, Aiko Shimizu, Ryosuke Ikemachi, Yosuke Okazaki, Tomoyuki Ota, Hiroshi Matsumoto, Shotaro Miyamoto, Munechika Tsumura, Seiya Hayashi, Michiari Umakoshi, Koji Hirashita, Mizuo Ando

    Acta medica Okayama   78 ( 4 )   337 - 343   2024年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Here, we describe the unique case of a pneumocephalus originating from an inverted papilloma (IP) in the frontoethmoidal sinus. A 71-year-old man with diabetes presented with headaches and altered consciousness. Imaging revealed the pneumocephalus together with bone destruction in the left frontal sinus. He underwent simultaneous endoscopic endonasal and transcranial surgery using an ORBEYE exoscope. Pathological diagnosis of the tumor confirmed IP. Post-surgery, the pneumocephalus was significantly resolved and the squamous cell carcinoma antigen level, which had been elevated, decreased. This case underscores the importance of a multidisciplinary approach and innovative surgical methods in treating complex sinonasal pathologies.

    DOI: 10.18926/AMO/67550

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  • Squamous cell carcinoma initially occurring on the tongue dorsum: a case series report with molecular analysis 査読 国際誌

    Sawako Ono, Katsutoshi Hirose, Shintaro Sukegawa, Kyoichi Obata, Masanori Masui, Kazuaki Hasegawa, Ai Fujimura, Katsumitsu Shimada, Satoko Nakamura, Akari Teramoto, Yumiko Hori, Eiichi Morii, Daisuke Motooka, Takuro Igawa, Takehiro Tanaka, Hitoshi Nagatsuka, Satoru Toyosawa, Hidetaka Yamamoto

    Diagnostic Pathology   19 ( 1 )   63 - 63   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Background

    Squamous cell carcinoma (SCC) of the dorsum of the tongue is extremely rare, and it clinically resembles various benign lesions. Somatic mutations in TP53 and some driver genes were implicated in the development of SCC; however, the somatic genetic characteristics of dorsal tongue SCC remain unknown. With a detailed analysis of gene mutations in dorsal tongue SCC, we aimed to better understand its biology.

    Methods

    Four cases of SCC initially occurring on the tongue dorsum were evaluated for clinical and histological findings and immunohistochemical expression of p53 and p16. Gene mutations were analyzed using next-generation sequencing with a custom panel of driver genes.

    Results

    We retrospectively investigated 557 cases of tongue SCC, and only four cases of SCC initially occurred on the tongue dorsum. The four patients (cases 1–4) were one woman and three men with a mean age of 53.75 years (range: 15–74 years). Histological analysis revealed well-differentiated SCC. Through molecular analysis, we identified pathogenic somatic mutations, namely, TP53 p.C176F (c.527G &gt; T) in case 3 and TP53 p.R282W (c.844 C &gt; T) in case 4. No pathogenic variants were identified in the PI3K/AKT or RAS/RAF pathways. The p53 immunohistochemical examination revealed a wild-type expression pattern in cases 1–3 and strong expression in case 4. The results of p16 immunostaining were negative in all cases.

    Conclusions

    We described four previously unreported genetic characteristics of dorsal tongue SCC. Somatic TP53 mutations may contribute to the development of a subset of dorsal tongue SCC; however, more cases with genetic analysis need to be accumulated.

    DOI: 10.1186/s13000-024-01487-0

    PubMed

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    その他リンク: https://link.springer.com/article/10.1186/s13000-024-01487-0/fulltext.html

  • 耳下腺に発生したCarcinoma showing thymus-like differentiation(CASTLE)の一例

    小野 早和子, 西田 賢司, 柳井 広之, 井川 卓朗, 田中 健大, 山元 英崇

    日本病理学会会誌   113 ( 1 )   346 - 346   2024年2月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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▼全件表示

MISC

  • MALTリンパ腫と骨髄腫の鑑別が問題となった一例

    小野 早和子, 佐藤 康晴, 西森 久和, 吉野 正

    日本リンパ網内系学会会誌   58   109 - 109   2018年5月

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    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

    J-GLOBAL

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  • MALTリンパ腫と骨髄腫の鑑別が問題となった一例

    小野 早和子, 佐藤 康晴, 西森 久和, 吉野 正

    日本病理学会会誌   107 ( 1 )   441 - 441   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

    J-GLOBAL

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  • 口腔扁平上皮癌の癌化過程におけるYAPおよび関連因子の検討

    小野 早和子, 中野 敬介, 高畠 清文, 河合 穂高, 吉田 沙織, 浜田 芽衣, 藤井 昌江, 信長 ひかり, 辻極 秀次, 長塚 仁

    日本病理学会会誌   106 ( 1 )   298 - 298   2017年3月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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  • 口腔扁平上皮癌におけるYAPの発現

    小野 早和子, 中野 敬介, 高畠 清文, 河合 穂高, 吉田 沙織, 浜田 芽衣, 藤井 昌江, 信長 ひかり, 辻極 秀次, 長塚 仁

    日本病理学会会誌   105 ( 1 )   420 - 420   2016年4月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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共同研究・競争的資金等の研究

  • 若年者口腔扁平上皮癌におけるYAPとその関連因子の役割と動態

    研究課題/領域番号:21K17114  2021年04月 - 2024年03月

    日本学術振興会  科学研究費助成事業  若手研究

    小野 早和子

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    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    若年者口腔扁平上皮癌の発生や、その進展にかかわる因子を検出するため、若年者の口腔扁平上皮癌症例の臨床病理学的所見について研究を進めている。若年者の口腔扁平上皮癌症例について当院の診療録から該当症例をピックアップし、必要な項目を抽出した。通常の高齢者の口腔扁平上皮癌症例とは異なり、若年者の場合は非常に症例数が少なく、当院症例のみでは症例数は不十分と考えられた。よって、多施設での若年者症例の症例集積が必要と考えられ、多施設共同研究へと変更することとなった。
    また研究の目的に挙げている「若年者口腔扁平上皮癌の原因因子と予後の検索」に関しては、高齢者の口腔扁平上皮癌症例の臨床病理学的所見との比較検討を行っているが、これによりデータ量も非常に多くなってきているのが現状である。若年者および高齢者症例の組織切片切り出しや検討すべき因子に対する抗体の取り寄せ等を行っているが、これらは昨今のCOVID-19感染症蔓延により進行がやや遅れている。すでに用意のできている組織切片、抗体を用いて順に染色とその評価を開始している。

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担当授業科目

  • 病理学Ⅱ (2024年度) 特別  - その他

  • 病理学Ⅱ実習 (2024年度) 特別  - その他