Faculty Profiles - IGAWA Kazuyo

Papers - IGAWA Kazuyo

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テトラポッド形状骨補填材 Reviewed

井川和代, 富塚健, 大庭伸介, 小笠原徹, 近津大地, 森良之, 高戸毅, 鄭雄一

日本口腔外科学会雑誌 53 ( Suppl. ) 177 - 177 2007.8

A novel osteogenic helioxanthin-derivative acts in a BMP-dependent manner. Reviewed International journal

Shinsuke Ohba, Keiji Nakajima, Yusuke Komiyama, Fumitaka Kugimiya, Kazuyo Igawa, Keiji Itaka, Toru Moro, Kozo Nakamura, Hiroshi Kawaguchi, Tsuyoshi Takato, Ung-il Chung

Biochemical and biophysical research communications 357 ( 4 ) 854 - 60 2007.6

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

To effectively treat serious bone defects using bone regenerative medicine, there is a need for the development of a small chemical compound that potently induces bone formation. We now report a novel osteogenic helioxanthin-derivative, TH. TH induced osteogenic differentiation in MC3T3-E1 cells, mouse primary osteoblasts, and mouse embryonic stem cells. The combination of TH and bone morphogenetic protein (BMP) 2 induced the mRNA expression of osteoblast marker genes and calcification in primary fibroblasts. The TH induced the mRNA of the inhibitor of DNA-binding 1 (Id-1), and its osteogenic effect was inhibited by Smad6 or Noggin. Furthermore, TH induced the mRNA expression of Bmp4 and Bmp6. These data suggest that TH exerts its potent osteogenic effect in a BMP-dependent manner by enhancing the effects of the existing BMPs and/or increasing the expression of Bmp4 and Bmp6. TH may help establish a more efficient bone regeneration system.

DOI： 10.1016/j.bbrc.2007.03.173

Web of Science

PubMed

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骨形成性シグナル経路の最適化と幹細胞を用いない新規骨再生法の開発 Reviewed

大庭伸介, 矢野文子, 井川和代, 藤原夕子, 小笠原徹, 近津大地, 森良之, 米原啓之, 須佐見隆史, 鄭雄一, 高戸毅

日本口腔科学会雑誌 56 ( 1 ) 112 - 112 2007

新しい医療を築く組織工学顎骨再建

西條英人, CHUNG Ung-il, 井川和代, 井川和代, 高戸毅, 高戸毅

人工臓器(日本人工臓器学会) 36 ( 1 ) 113 - 116 2007

Language：Japanese Publisher：(一社)日本人工臓器学会

頭蓋顎顔面骨における骨再建に対して、より良い人工骨を求めて次世代人工骨の開発に取り組んだ。18歳女。汎発性強皮症に伴う顔面変形を主訴で受診した。顔面は非対称性で、右側の中〜下顔面に陥凹を認めた。術後における脂肪組織の下垂や二次変形、女性における採取部の傷を避けることなどを考慮し、硬組織再建を選択した。すなわち陥凹部にカスタムメイド人工骨を移植することにより硬組織を再建し、顔貌の改善を図った。人工骨の作製には3次元造形モデルを応用した。術後3ヵ月経過した3次元CT画像では人工骨の位置のズレは認めず、顔貌形態についても満足した形態が得られた。さらに、術後6ヵ月経過した現在、大きな合併症を併発することなく経過している。

DOI： 10.11392/jsao1972.36.113

J-GLOBAL

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J00706&link_issn=&doc_id=20070717290015&doc_link_id=10.11392%2Fjsao1972.36.113&url=https%3A%2F%2Fdoi.org%2F10.11392%2Fjsao1972.36.113&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Microchip-based osteosis system for rapid drug screening for osteogenesis

Kae Sato, Kazuyo Igawa, Yuki Tanaka, Kiichi Sato, Ung-Il Chung, Takehiko Kitamori

Micro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences 1008 - 1010 2006

Language：English Publishing type：Research paper (international conference proceedings) Publisher：Japan Academic Association Inc

In the geriatric research field, osteoporosis is the major target of regenerative medicine and osteoblast is known as a key cell to osteoporosis. We developed continuous perfusion microfluidic cell culture system for osteoblast differentiation drug screening assays. © 2006 Society for Chemistry and Micro-Nano Systems.

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Mechanism of osteogenic induction by FK506 via BMP/Smad pathways Reviewed

F Kugimiya, F Yano, S Ohba, K Igawa, K Nakamura, H Kawaguchi, UI Chung

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 338 ( 2 ) 872 - 879 2005.12

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS INC ELSEVIER SCIENCE

FK506 is an immunosuppressant that exerts effects by binding to FK506-binding protein 12 (FKBP12). Recently, FK506 has also been reported to promote osteogenic differentiation when administered locally or in vitro in combination with bone morphogenetic proteins (BMPs), although the underlying mechanism remains unclarified. The present study initially showed that FK506 alone at a higher concentration (1 mu M) induced osteogenic differentiation of mesenchymal cell lines, which was suppressed by adenoviral introduction of Smad6. FK506 rapidly activates the BMP-dependent Smads in the absence of BMPs, and the activation was blocked by Smad6. Overexpression of FKBP 12, which was reported to block the ligand-independent activation of BMP type I receptor A (BMPRIA), suppressed Smad signaling induced by FK506, but not that induced by BMP2. BMPRIA and FKBP12 bound to each other, and this binding was suppressed by FK506. These data suggest that FK506 promotes osteogenic differentiation by activating BMP receptors through interacting with FKBP12. (c) 2005 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2005.10.024

Web of Science

PubMed

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Operation Simulation System Using 3D Models Fabricated by the 3D Printer.

西條英人, 井川和代, 鄭雄一, 米原啓之, 高戸毅

?日本形成外科学会会誌? 54 ( 4 ) 525 - 526 2005.9

老年医学の展望骨・軟骨の再生医療

大庭伸介, 井川和代, 中村耕三, 川口浩, 高戸毅, 鄭雄一

?日本老年医学会雑誌 40 ( 1 ) 264 - 266 2004

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