論文 - 松本　准

Changes in degree of recognition and understanding of pharmacy students and its evaluation in palliative care education 査読

Yasunari Mano, Risa Hitomi, Remi Tamura, Yoshinori Kato, Kaori Ohuchi, Iori Hirosawa, Masataka Tajima, Jun Matsumoto, Kayoko Maezawa, Harumi Yamada, Yasuyuki Momose, Mariko Asahi

Japanese Journal of Drug Information   17 ( 2 )   100 - 105   2015年

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記述言語：日本語   掲載種別：研究論文（学術雑誌）   出版者・発行元：一般社団法人 日本医薬品情報学会  

Objective: In this study, we evaluated the change in degree of recognition and understanding of palliative care as pharmacy students' years advanced.<br>Methods: A questionnaire survey consisting of 11 items about recognition of narcotics and 27 items about understanding of palliative care was conducted with first- to fifth-year pharmacy students.  We divided the questions about the image of narcotics into groups and classified the questions about their knowledge of palliative care into the categories based on some reports.<br>Results: Among the three groups of questions about the image of narcotics, the degree of "right recognition of narcotics" increased, and those of "wrong recognition of narcotics" and "sense of resistance to narcotics" decreased as pharmacy students' years advanced.  Additionally, questions about their knowledge of palliative care were categorized into three: "basic guidelines for cancer pain relief and methods of narcotic use," "role of pharmacists in palliative care and support for patients," and "pharmacologic characteristics of narcotics."  Their degree of understanding of each category increased with an increase in years.  Both the recognition of narcotics and understanding of palliative care changed in the fourth- and fifth-grade year students compared to the first-, second-, and third-year ones.<br>Conclusion: These results suggest that the recognition and understanding of palliative care changed along the same trends as pharmacy students' years advanced.  Therefore, it is important that pharmacy students acquire appropriate knowledge to play an active role in palliative care.

DOI： 10.11256/jjdi.17.100

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その他リンク： http://search.jamas.or.jp/link/ui/2016092766

Functional characterization of seven single-nucleotide polymorphisms of the steroid sulfatase gene found in a Japanese population 査読

Jun Matsumoto, Noritaka Ariyoshi, Itsuko Ishii, Mitsukazu Kitada

Journal of Human Genetics   58 ( 5 )   267 - 272   2013年5月

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：NATURE PUBLISHING GROUP  

Steroid sulfatase (STS) is an enzyme that hydrolyzes steroid sulfates such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate. STS has a key role in the synthesis of steroid hormones in placenta and breast cancer cells. Recently, we have identified six novel single-nucleotide polymorphisms (SNPs) and one nonsynonymous SNP (V476M) in the STS gene in a Japanese population. To clarify the effects of SNPs in the 5'-flanking region or 5' untranslated region on transcriptional activity, a reporter gene assay was conducted. In addition, DHEA-S desulfatase activity of a variant (Met at codon 476)-type enzyme was compared with that of the wild (Wd)-type enzyme in COS-1 cells. The transcriptional activities were significantly decreased (155A) and increased (-2837A and -1588C) in MCF-7 cells. On the other hand, no significant difference was found in expression levels of STS protein or specific activities of DHEA-S desulfation between Wd and the variant enzymes. This is the first report on the effects of various SNPs in the STS gene detected in Japanese healthy subjects.

DOI： 10.1038/jhg.2013.12

Web of Science

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Development of a simple method for detection of the HLA-A*31:01 allele 査読

Kazuki Uchiyama, Fumika Kubota, Noritaka Ariyoshi, Jun Matsumoto, Itsuko Ishii, Mitsukazu Kitada

Drug Metabolism and Pharmacokinetics   28 ( 5 )   435 - 438   2013年

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society for the Study of Xenobiotics  

It is known that rare but severe cutaneous adverse drug reactions (cADRs), such as Stevens- Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS), are induced by carbamazepine (CBZ). Recent studies have shown an association between HLAA* 31:01 and CBZ-induced severe cADRs in Japanese and Caucasian populations. In this study, we developed a simple method to detect the HLA-A*31:01 allele by nested allele-specific primer-polymerase chain reaction combined with restriction fragment length polymorphism analysis. Accuracy of the developed method was evaluated by direct sequencing analysis of PCR products amplified from DNA samples with known HLA-A genotypes and by consigning diagnosis of DNA samples with unknown HLA-A genotypes to a company providing clinical laboratory testing. The method developed in this study is simple, rapid, and of low cost compared to outsourcing tests and may be useful for in-house testing of the HLA-A*31:01 allele. © 2013 by the Japanese Society for the Study of Xenobiotics (JSSX).

DOI： 10.2133/dmpk.DMPK-12-NT-136

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Six novel single nucleotide polymorphisms of the steroid sulfatase gene in a Japanese population 査読

Jun Matsumoto, Noritaka Ariyoshi, Itsuko Ishii, Mitsukazu Kitada

Drug Metabolism and Pharmacokinetics   25 ( 4 )   403 - 407   2010年

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society for the Study of Xenobiotics  

Steroid sulfatase (STS) is a microsomal enzyme responsible for the formation of 3β-hydroxysteroid from the corresponding sulfate conjugates. Screening of all exons, exon-intron boundaries and the 5'-flanking region of the STS gene in 93 healthy Japanese individuals was carried out. Among seven single nucleotide polymorphisms (SNPs) identified in this study, six were novel, including one in the untranslated region of exon 1, one in exon 10, and four in the 5'-flanking region. The nonsynonymous SNP (1647G&gt
A) in exon 10 caused amino-acid replacement, Val476Met, with a frequency of 0.014. The allele frequencies of the other SNPs were 0.071 for 155G&gt
A, 0.007 for -21G&gt
A, 0.014 for -1117T&gt
C, 0.106 for -1588G&gt
A, 0.007 for -2427G&gt
A and 0.007 for -2837T&gt
C.

DOI： 10.2133/dmpk.DMPK-10-SC-027

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