Papers - TETSUNAGA Tomoko

Efficacy of Pregabalin for Patients with Neuropathic Pain and Degenerative Lumbar Disease

Tetsunaga Tomoko, Tanaka Masato, Sugimoto Yoshihisa, Misawa Haruo, Takigawa Tomoyuki, Shiozaki Yasuyuki, Osaki Syuhei, Mazaki Tetsuro, Yamane Kentarou, Ozaki Toshifumi

The Journal of the Chugoku-Shikoku Orthopaedic Association   24 ( 2 )   325 - 329   2012

　More details

Language：Japanese   Publisher：The Chugoku-Shikoku Orthopaedic Association  

The anti-seizure drug, pregabalin, is used for treatment of neuropathic pain and degenerative lumbar disease. The objective of this study was to evaluate the effect of pregabalin (150-300 mg/day) in patients with chronic lower back/leg pain. We assessed 47 patients (17 men and 30 women) with an average age of 65 years (range 20 to 81 years), and an average disease duration of 87 months (range 3 to 480 months). All patients were assessed using a visual analogue scale (VAS, 0-100 mm), the Self-Rating Depression Scale (SDS, 20-80 points), and the Oswestry Disability Index (ODI, 0-100%). After 8 weeks, pregabalin improved lower back pain, leg pain, SDS and ODI significantly (P<0.01). Pain was improved significantly in the depression group as well as the normal group (P<0.01). Accepted sleepiness (51%), dizziness (19%), weight gain (16%) and rash (5%) were detected after medication. The use of the hypnotic agent was decreased in half of the cases after medication. Pregabalin is safe and effective for decreasing lower back pain and leg pain in patients with depression.

DOI： 10.11360/jcsoa.24.325

CiNii Article

researchmap

Other Link： http://search.jamas.or.jp/link/ui/2013107559

Intradermal administration of magnesium sulphate and magnesium chloride produces hypesthesia to mechanical but hyperalgesia to heat stimuli in humans. International journal

Takahiro Ushida, Osamu Iwatsu, Kazuhiro Shimo, Tomoko Tetsunaga, Masahiko Ikeuchi, Tatsunori Ikemoto, Young-Chang P Arai, Katsutoshi Suetomi, Makoto Nishihara

Journal of neuroinflammation   6   25 - 25   2009.8

　More details

Language：English   Publishing type：Research paper (scientific journal)  

BACKGROUND: Although magnesium ions (Mg2+) are known to display many similar features to other 2+ charged cations, they seem to have quite an important and unique role in biological settings, such as NMDA blocking effect. However, the role of Mg2+ in the neural transmission system has not been studied as sufficiently as calcium ions (Ca2+). To clarify the sensory effects of Mg2+ in peripheral nervous systems, sensory changes after intradermal injection of Mg2+ were studied in humans. METHODS: Magnesium sulphate, magnesium chloride and saline were injected into the skin of the anterior region of forearms in healthy volunteers and injection-induced irritating pain ("irritating pain", for short), tactile sensation, tactile pressure thresholds, pinch-pain changes and intolerable heat pain thresholds of the lesion were monitored. RESULTS: Flare formation was observed immediately after magnesium sulphate or magnesium chloride injection. We found that intradermal injections of magnesium sulphate and magnesium chloride transiently caused irritating pain, hypesthesia to noxious and innocuous mechanical stimulations, whereas secondary hyperalgesia due to mechanical stimuli was not observed. In contrast to mechanical stimuli, intolerable heat pain-evoking temperature was significantly decreased at the injection site. In addition to these results, spontaneous pain was immediately attenuated by local cooling. CONCLUSION: Membrane-stabilizing effect and peripheral NMDA-blocking effect possibly produced magnesium-induced mechanical hypesthesia, and extracellular cation-induced sensitization of TRPV1 channels was thought to be the primary mechanism of magnesium-induced heat hyperalgesia.

DOI： 10.1186/1742-2094-6-25

PubMed

researchmap

【脊髄・末梢神経疾患】随意収縮下に誘発される上肢筋伸張反射(T波) 健常人と頸部神経根症における検討

鉄永 倫子, 谷 俊一, 谷口 愼一郎, 石田 健司, 池本 竜則, 一宮 正博

臨床脳波   50 ( 5 )   257 - 264   2008.5

　More details

Language：Japanese   Publisher：(株)永井書店  

目的:上肢筋伸張反射を安定して記録するために随意収縮下にT波を誘発した。対象:健常者80名と片側性頸部神経根症11名であった。結果:健常者のT波検出率は、両側95%以上であった。健常者のデータをもとに症例を検討したところ左右潜時差と振幅比からの判定が有用であった。考察:上腕二頭筋ではC5根、腕橈骨筋ではC6根、上腕三頭筋ではC7根、第一背側骨間筋ではC8根の異常の判定が可能と思われた。(著者抄録)

researchmap

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01558&link_issn=&doc_id=20080508060001&doc_link_id=%2Faf2rsnhd%2F2008%2F005005%2F001%2F0257-0264%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faf2rsnhd%2F2008%2F005005%2F001%2F0257-0264%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif