研究者詳細 - 杉本　幸雄

論文 - 杉本　幸雄

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Vascular permeability in allergic conjunctivitis in mice lacking histamine H<inf>1</inf> receptors

Hiroto Nakahara, Keiji Izushi, Yukio Sugimoto, Takeshi Watanabe, Chiaki Kamei

European Journal of Pharmacology 409 ( 3 ) 313 - 317 2000年12月

掲載種別：研究論文（学術雑誌）

To clarify the role of histamine H1 receptors in allergic conjunctivitis, changes in vascular permeability of the conjunctiva were measured in histamine H1 receptor deficient mice. Wild-type mice showed a significant increase in vascular permeability of the conjunctiva induced by histamine. However, no such increase was found in histamine H1 receptor deficient mice. On the other hand, no differences were observed between wild-type and histamine H1 receptor deficient mice in response to serotonin. A significant increase in vascular permeability was observed in actively sensitized wild-type mice, whereas no increase was observed in histamine H1 receptor deficient mice. Similar findings were noted in passively sensitized animals. Histamine contents of the conjunctiva were significantly decreased by topical application of antigen in both wild-type and histamine H1 receptor deficient mice after active sensitization with antigen. These findings suggested that vascular permeability in the conjunctiva in allergic conjunctivitis is entirely regulated through histamine H1 receptor. (C) 2000 Elsevier Science B.V.

DOI： 10.1016/S0014-2999(00)00863-3

Effect of mometasone furoate by topical application on allergic rhinitis model in rats

Yukio Sugimoto, Keisuke Ishizawa, Kouichi Saitou, Genzo Suzuki, Tadatsugu Tarumi, Hiroto Nakahara, Yasushi Kirino, Chiaki Kamei

Pharmacology 61 ( 2 ) 91 - 95 2000年8月

掲載種別：研究論文（学術雑誌）

The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate. Topical application of both drugs inhibited dose-dependently the increase of nasal symptoms (sneezing and nasal rubbing) after antigen challenge to the nasal cavity of actively sensitized rats. Mometasone furoate and fluticasone propionate at concentrations of 0.01 or 0.1% significantly inhibited both nasal rubbing and sneezing 1 h after topical application of both drugs. The relative potencies of mometasone furoate in nasal rubbing and sneezing compared to fluticasone propionate were 5.01 and 6.87, respectively. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibited the increase of antigen-induced nasal rubbing even 6 h after topical application, indicating that both drugs have a long-lasting effect. Copyright (C) 2000 S. Karger AG, Basel.

DOI： 10.1159/000028386

A new model of allergic rhinitis in rats by topical sensitization and evaluation of H<inf>1</inf>-receptor antagonists

Yukio Sugimoto, Etsuko Kawamoto, Zhong Chen, Chiaki Kamei

Immunopharmacology 48 ( 1 ) 1 - 7 2000年6月

掲載種別：研究論文（学術雑誌）

An animal model of chronic allergic rhinitis was developed by repeated local booster sensitization into the nasal cavity in sensitized rats. The severity of allergic rhinitis was assessed by determining the extent of two markers of nasal allergic symptoms (sneezing and nasal rubbing) after antigen challenge. The number of incidents of sneezing and nasal rubbing was markedly increased during intranasal instillation of antigen in sensitized rats. The PCA titers were also markedly elevated by intranasal sensitization. Some histamine H1-receptor antagonists such as chlorpheniramine, ketotifen, astemizole and epinastine inhibited the increase in antigen-induced nasal symptoms in a dose-related manner. Nasal rubbing was more potently inhibited by H1-receptor antagonists than sneezing.In conclusion, we developed a chronic allergic rhinitis model showing nasal symptoms in rats, and this model may be useful for evaluating the effects of drugs on allergic rhinitis. Copyright (C) 2000 Elsevier Science B.V.

DOI： 10.1016/S0162-3109(00)00173-9

Experimental allergic conjunctivitis in guinea pigs induced by Japanese cedar pollen

Miho Takada, Tamao Yamada, Hiroto Nakahara, Yukio Sugimoto, Keiji Izushi, Chiaki Kamei

Biological and Pharmaceutical Bulletin 23 ( 5 ) 566 - 569 2000年5月

掲載種別：研究論文（学術雑誌）

We report a new experimental allergic conjunctivitis with Japanese cedar pollen as antigen in guinea pigs, and the immunological characteristics of this model were also elucidated. Allergic conjunctivitis was developed by immunization in guinea pigs with a mixture containing Japanese cedar pollen and killed Bordetella pertussis. When local application of Japanese cedar pollen suspension 14 d after systemic immunization was performed every 3 d, remarkable conjunctivitis was observed from 20 to 35d. Increase in vascular permeability and decrease in histamine contents of the conjunctiva were also observed after local application of antigen. Passive cutaneous anaphylactic (PCA) reactions revealed that both IgG- and IgE-rich antibodies were produced in this model. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting cedar pollen-induced conjunctivitis. Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen.

DOI： 10.1248/bpb.23.566

Effects of metabolic fragments of [Arg⁸]-vasopressin on nerve growth in cultured hippocampal neurons

Tadatsugu Tarumi, Yukio Sugimoto, Zhong Chen, Qiue Zhao, Chiaki Kamei

Brain Research Bulletin 51 ( 5 ) 407 - 411 2000年4月

掲載種別：研究論文（学術雑誌）

The effects of metabolic fragments of [Arg8]-vasopressin (AVP), [pGlu4, Cyt6]AVP (AVP4-9), and desglycinamide-[pGlu4, Cyt6]AVP (AVP4-8) on the growth of hippocampal neurons in culture were investigated in comparison with those of AVP. AVP4-9 caused a significant increase in filopodial length following 96 h of exposure at concentrations higher than 300 nM. AVP4-9 was more potent than AVP. AVP4-8 also induced an increase in filopodial length, but this effect was less than that of AVP. The selective V1 agonist [Phe2, Ile3, Orn8]-vasopressin caused a significant increase in filopodial length, whereas the selective V2 agonist [deamino-Cys1, D-Arg8]-vasopressin showed no such effect. OPC-21268, a vasopressin V1 antagonist, blocked AVP and AVP fragment-induced increases in filopodial length. However, the V2 antagonist OPC-31260 showed no such effect. A23187, a representative Ca ionophore, also increased filopodial length, and the A23187-induced increase in filopodial length was potentiated by AVP and AVP fragments. These results indicated that AVP4-9 and AVP4-8 increased filopodial length in cultured hippocampal neurons by activating V1 receptors. Both phenomena induced by AVP4-9 and AVP4-8 were associated with intracellular calcium mobilization. Copyright (C) 2000 Elsevier Science Inc.

DOI： 10.1016/S0361-9230(99)00249-X

The mechanism responsible for the drowsiness caused by first generation H<inf>1</inf> antagonists on the EEG pattern

Y. Kaneko, K. Shimada, K. Saitou, Y. Sugimoto, Chiaki Kamei

Methods and Findings in Experimental and Clinical Pharmacology 22 ( 3 ) 163 - 168 2000年

掲載種別：研究論文（学術雑誌）

The present study was performed to clarify the mechanism responsible for the drowsiness caused by first generation H1 antagonists according to electroencephalogram activity. All H1 antagonists used in the present study caused the EEG-recorded drowsiness pattern, i.e., increases in EEG power spectra of the δ and θ bands at the frontal cortex in rats. The potency of cyproheptadine was greater than those of diphenhydramine and promethazine, while that of pyrilamine was less than those of the other drugs examined. The increase in EEG power spectra in the δ band induced by H1 antagonists was antagonized by pretreatment with both histidine and physostigmine. The effect of pyrilamine was more potently antagonized by histidine and less potently antagonized by physostigmine as compared to diphenhydramine, promethazine and cyproheptadine. The increases in EEG power spectra induced by H1 antagonists were neither antagonized nor potentiated by 5-hydroxytryptophan. These results clearly indicate that the increases in EEG power spectra in the δ and θ bands at the frontal cortex in rats induced by first generation H1 antagonists are responsible for both histaminergic and cholinergic mechanisms. (C) 2000 Prous Science.

Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures

Keisuke Ishizawa, Zhong Chen, Chihiro Okuma, Yukio Sugimoto, Yoko Fujii, Chiaki Kamei

Japanese Journal of Pharmacology 82 ( 1 ) 48 - 53 2000年

掲載種別：研究論文（学術雑誌）

The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures. I.p. injection of clobenpropit caused dose-dependent inhibition of amygdaloid kindled seizures. GABAmimetic drugs such as diazepam, sodium valproate and muscimol also inhibited amygdaloid kindled seizures in a dose-dependent manner. Diazepam at doses of 0.2 and 0.5 mg/kg, which showed no significant effect on amygdaloid kindled seizures when used separately, significantly potentiated the effect of clobenpropit. Similar findings were observed with sodium valproate and muscimol at doses of 100 mg/kg and 5 ng, respectively, although neither showed any significant effects when administered separately. Bicuculline caused significant antagonism of the inhibition of amygdaloid kindled seizures induced by clobenpropit, while the effect of diazepam was not antagonized by diphenhydramine. These results suggested that inhibition of amygdaloid kindled seizures induced by histamine is closely associated with the actions of GABA.

DOI： 10.1254/jjp.82.48

Effects of Fujibitol, a remedy for nasal symptoms, on experimental allergic rhinitis in rats

M. Kakimoto, Y. Sugimoto, M. Harada, Y. Kobayashi, C. Okuma, C. Taga, C. Kamei

Biological and Pharmaceutical Bulletin 23 ( 9 ) 1055 - 1058 2000年

掲載種別：研究論文（学術雑誌）

The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, i.e. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity induced by antigen was also inhibited by Fujibitol. On the other hand, no inhibitory effects were observed on either the nasal allergic symptoms or increase in dye leakage into the nasal cavity induced by histamine. However, Fujibitol was effective in inhibiting histamine release from the nasal cavity induced by antigen. Oxatomide used as positive control drug showed potent inhibitory effects on nasal symptoms and dye leakage into the nasal cavity induced by histamine and antigen. These results suggested that Fujibitol showed a remarkable protective effect against experimental rhinitis induced by antigen via inhibition of histamine release from the nasal cavity.

DOI： 10.1248/bpb.23.1055

Influences of everninomicin, vancomycin and teicoplanin on chemical mediator release from rat peritoneal mast cells

Y. Sugimoto, Y. Iba, K. Utsugi, C. Kamei

Japanese Journal of Pharmacology 83 ( 4 ) 300 - 305 2000年

掲載種別：研究論文（学術雑誌）

We examined influences of certain antibiotics on the release of chemical mediators from isolated rat peritoneal mast cells in vitro. Isolated peritoneal mast cells were obtained from male Wistar strain rats. Everninomicin (0.06 - 1.2 mg/ml), vancomycin (0.05 - 1.0 mg/ml), teicoplanin (0.07 - 1.4 mg/ml) and concanavalin A (0.01 mg/ml) were used. Isolated mast cells were incubated in the presence of various concentrations of the test compound at 37°C for 10 min. Histamine contents of the supernatant and cell pellet were measured by an automated fluorometric method. Prostaglandin D2 (PGD2) contents of the supernatant were determined by enzyme immunoassay. Everninomicin (0.06 - 1.2 mg/ml) had no influence on histamine and PGD2 release from mast cells. On the other hand, vancomycin significantly released both histamine (0.5 and 1.0 mg/ml) and PGD2 (1.0 mg/ml) from mast cells, but vancomycin did not affect concanavalin A-induced histamine and PGD2 release. Teicoplanin (more than 0.07 mg/ml) significantly stimulated histamine and PGD2 release from mast cells and it also significantly potentiated concanavalin A-induced histamine and PGD2 release. These results suggest that everninomicin causes no chemical mediator release from mast cells, different from vancomycin and teicoplanin.

DOI： 10.1254/jjp.83.300

Effect of propolis extract on D-galactosamine-induced hepatic injury in rats

Yukio Sugimoto, Tadatsugu Tarumi, Yoshio Kaneko, Shinji Isayama, Nobuyuki Kawai, Hiroyuki Sugimoto, Hideo Yamada, Chiaki Kamei

Biological and Pharmaceutical Bulletin 22 ( 11 ) 1237 - 1239 1999年11月

掲載種別：研究論文（学術雑誌）

The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose- dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.

DOI： 10.1248/bpb.22.1237

Effects of intracerebroventricular injection of α-fluoromethylhistidine on radial maze performance in rats

Zhong Chen, Yukio Sugimoto, Chiaki Kamei

Pharmacology Biochemistry and Behavior 64 ( 3 ) 513 - 518 1999年11月

掲載種別：研究論文（学術雑誌）

The effects of α-fluoromethylhistidine (α-FMH) on spatial cognition were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (ICV) injection of α-FMH resulted in spatial memory deficits characterized by an increase in the number of total errors (TE) and a decrease in the number of initial correct responses (ICR). There was a strong correlation between increases in the number of TE and decreases in histamine contents of the cortex and hippocampus regions of the brain, which are known to participate in learning and memory. On the other hand, both histamine (50-100 ng, ICV) and thioperamide (10 μg, ICV) significantly ameliorated the memory deficit induced by α-FMH. However, metoprine showed no significant effect on the α-FMH-induced memory deficit. Pyrilamine and R-(α)-methylhistamine enhanced the memory deficit induced by α-FMH, at doses that had no appreciable effect when administered alone. In contrast, no significant influence on α-FMH-induced memory deficit was observed with zolantidine. Copyright (C) 1999 Elsevier Science Inc.

DOI： 10.1016/S0091-3057(99)00128-8

Slow wave sleep-inducing effects of first generation H<inf>1</inf>-antagonists

Koichi Saitou, Yoshio Kaneko, Yukio Sugimoto, Zhong Chen, Chiaki Kamei

Biological and Pharmaceutical Bulletin 22 ( 10 ) 1079 - 1082 1999年10月

掲載種別：研究論文（学術雑誌）

The present study was performed to see if first-generation histamine H1-antagonists are useful sedative-hypnotic drugs. Increases in electroencephalogram (EEG) power spectra of the delta band (0-4 Hz) at the frontal cortex and theta band (4-8 Hz) at the hippocampus in rats were used as an indexes of sleep. The H1-antagonists used in this study resulted in a decrease in sleep latency and an increase in sleep duration (slow wave sleep). The rate of REM (rapid eye movement) sleep during slow wave sleep was decreased by H1-antagonists and brotizolam. The order of potency of H1- antagonists for the reduction in sleep latency (from greatest to least) was promethazine>chlorpheniramine>diphenhydramine and pyrilamine, and that for the increase in sleep duration was chlorpheniramine>promethazine>diphenhydramine and pyrilamine. Brotizolam was more potent than these H1-antagonists, with 14-18-fold and 4-14-fold greater effects on sleep latency and duration, respectively. These results clearly show that H1-antagonists are effective in mild to moderate insomnia as sedative-hypnotic drugs.

DOI： 10.1248/bpb.22.1079

Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

Zhong Chen, Quie Zhao, Yukio Sugimoto, Yoko Fujii, Chiaki Kamei

Brain Research 839 ( 1 ) 186 - 189 1999年8月

掲載種別：研究論文（学術雑誌）

The effects of histamine on the spatial memory deficits induced by MK- 801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2- thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H1-receptors.

DOI： 10.1016/S0006-8993(99)01739-4

[Arg⁸]-vasopressin-induced increase in intracellular Ca²⁺ concentration in cultured rat hippocampal neurons

Takuma Mihara, Tadatsugu Tarumi, Yukio Sugimoto, Zhong Chen, Chiaki Kamei

Brain Research Bulletin 49 ( 5 ) 343 - 347 1999年7月

掲載種別：研究論文（学術雑誌）

Changes in intracellular Ca2+ concentration ([Ca2+](i)) induced by [Arg8]-vasopressin (AVP) were studied in cultured rat hippocampal neurons by fura-2 fluorometry. AVP (10-1,000 nM) caused a dose-dependent increase in [Ca2+](i). The selective V1 vasopressin receptor agonist [Phe2, Ile3, Orn8]vasopressin also induced a significant increase in [Ca2+](i), whereas the selective V2 vasopressin receptor agonist [deamino Cys1, D-Arg8]- vasopressin showed no effect. The AVP-induced increase in [Ca2+](i) was inhibited by the selective V1 vasopressin receptor antagonist d(CH2)5[Tyr2(Me), Arg8]-vasopressin and nonpeptide V1 antagonist OPC- 21268. On the other hand, no antagonistic effects were observed with the V2 vasopressin antagonist desglycinamide-[d(CH2)5, D-Ile2, Ile4, Arg8]- vasopressin and nonpeptide V2 antagonist OPC-31260. The increase in [Ca2+](i) induced by AVP was abolished after removal of extracellular Ca2+. In addition, AVP-induced [Ca2+](i) elevation was not affected by treatment with verapamil, which blocked the [Ca2+](i) increase induced by an isotonic high K+- medium (50 mM). However, ω-conotoxin GVIA completely inhibited the effect of AVP. These results suggested that the AVP-induced [Ca2+](i) increase in cultured rat hippocampal neurons is due to influx of Ca2+ through V1 VP receptors coupled with N-type calcium channels.

DOI： 10.1016/S0361-9230(99)00064-7

Effects of fujibitol, a remedy for nasal symptoms of immediate and delayed type allergic reactions

Masanori Kakimoto, Naoyuki Takasugi, Tohru Fuwa, Hiroshi Saito, Yukio Sugimoto, Chiaki Kamei

Methods and Findings in Experimental and Clinical Pharmacology 21 ( 5 ) 353 - 356 1999年

掲載種別：研究論文（学術雑誌）

The effects of Fujibitol, a remedy for the nasal symptoms of immediate and delayed type allergic reactions were studied. Fujibitol inhibited active systemic anaphylaxis in mice, heterologous passive cutaneous anaphylaxis (PCA) in rats, Masugi's nephritis in rats and delayed type hypersensitivity induced by picryl chloride in mice, but did not affect homologous PCA or immune complex-induced glomerulonephritis in rats. These results suggested that Fujibitol is effective for treatment of allergy-induced inflammation since IgG and type IV allergic reactions were inhibited.

DOI： 10.1358/mf.1999.21.5.541913

Effects of levocabastine on lipid mediator release from guinea pig lung fragments

Yukio Sugimoto, Yoshinori Iba, Keisuke Ishizawa, Genzo Suzuki, Chiaki Kamei

Acta Medica Okayama 53 ( 6 ) 271 - 274 1999年

掲載種別：研究論文（学術雑誌）

The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10-4 M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.

Studies on the sleep-inducing effect of diphenhydramine hydrochloride

Chiaki Kamei, Koichi Saito, Yukio Sugimoto, Zhong Chen, Qiue Zhao

Japanese Pharmacology and Therapeutics 27 ( 5 ) 18 - 19 1999年

掲載種別：研究論文（学術雑誌）

The present study was undertaken to clarify whether or not diphenhydramine is useful for sedative-hypnotic drug. EEG power spectra of delta band (0-4 Hz) at the frontal cortex in rats was used for an index of sleep. Diphenhydramine at doses of 2-20mg/kg, p.o. caused a dose-dependent shortening of sleep latency and prolongation of sleep duration. Significant effect was observed at a dose of 10mg/kg or more. These effects were almost the same as those of chlorpheniramine and less than those of brotizolam. The results clearly indicate that diphenhydramine is effective sedative-hypnotic drug for mild insomnia.

Effects of histamine and related compounds on regional cerebral blood flow in rats

G. Suzuki, Z. Chen, Y. Sugimoto, Y. Fujii, C. Kamei

Methods and Findings in Experimental and Clinical Pharmacology 21 ( 9 ) 613 - 617 1999年

掲載種別：研究論文（学術雑誌）

The effects of histamine and related compounds on regional cerebral blood flow (rCBF) in the hippocampus of conscious rats were studied. Intracerebroventricular injection of histamine caused a dose-dependent increase in rCBF in the hippocampus, and similar findings were observed with not only the H1 agonist, 2-thiazolylethylamine, but also the H2 agonist, dimaprit. Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of histamine content in the brain. The increase in rCBF in the hippocampus induced by L- histidine was antagonized by both H1 and H2 antagonists (diphenhydramine, pyrilamine and zolantidine). In addition, when both antagonists were injected simultaneously, an additive effect was observed in antagonism of the L- histidine-induced increase in rCBF. L-Histidine caused no marked changes in blood pressure even at a dose of 1,500 mg/kg, which showed an increase in rCBF in the hippocampus. These results indicate that histamine elicited an increase in rCBF via both H1 and H2 receptors.

Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral 6-hydroxydopamine lesions in rats

T. Hayakawa, Y. Sugimoto, Z. Chen, Y. Fujii, C. Kamei

Clinical and Experimental Pharmacology and Physiology 26 ( 5-6 ) 421 - 425 1999年

掲載種別：研究論文（学術雑誌）

1. Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral lesions of dopaminergic neurons were investigated in rats. 2. Dopaminergic neurons in rats were lesioned bilaterally by injection of 6-hydroxydopamine (6-OHDA; 8 μg) into the medial forebrain bundle at the level of the posterolateral hypothalamus. As a result, a decrease in locomotor activity and marked catalepsy and prolongation of grasping time were observed. 3. Levodopa, talipexole, bromocriptine and theophylline dose- dependently antagonized the decrease in locomotor activity induced by bilateral 6-OHDA lesions. These drugs also showed antagonistic effects on the appearance of catalepsy and prolongation of grasping time induced by bilateral 6-OHDA lesions. In contrast, trihexyphenidyl showed no antagonizing effect on the neurobehavioural changes induced by 6-OHDA lesions at any concentration tested. 4. Combined treatment with levodopa and talipexole antagonized the neurobehavioural changes induced by bilateral 6-OHDA lesions, whereas no marked changes were observed when either drug was administered separately. The same findings were noted with the simultaneous use of either levodopa (2 mg/kg) and theophylline (2 mg/kg) or talipexole (0.005 mg/kg) and theophylline (2 mg/kg). 5. These results indicate that this model may be useful for estimating the effects of drugs in the treatment of Parkinson's disease.

DOI： 10.1046/j.1440-1681.1999.03051.x

432 ペパーミント抽出物のラット抗原誘発鼻アレルギーデルに対する効果

井上俊夫, 杉本幸雄, 亀井千晃

アレルギー 48 ( 8 ) 1052 - 1052 1999年

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