2021/04/08 更新

写真a

スギモト ユキオ
杉本 幸雄
SUGIMOTO Yukio
所属
医歯薬学域 准教授
職名
准教授
外部リンク

学位

  • 博士(薬学) ( 岡山大学 )

  • 薬学修士 ( 岡山大学 )

研究キーワード

  • ヒスタミン

  • アレルギー

  • Histamine

  • Allergy

研究分野

  • ライフサイエンス / 免疫学

  • ライフサイエンス / 薬理学

  • ライフサイエンス / 薬理学

  • ライフサイエンス / 薬系衛生、生物化学

学歴

  • 岡山大学   Graduate School, Division of Pharmaceutical Sciences  

    - 1988年

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  • 岡山大学    

    - 1988年

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    国名: 日本国

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  • 岡山大学   Faculty of Pharmaceutical Science  

    - 1986年

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  • 岡山大学   薬学部   製薬化

    - 1986年

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    国名: 日本国

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経歴

  • - 岡山大学医歯薬学総合研究科 准教授

    2004年

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  • - Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2004年

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所属学協会

▼全件表示

委員歴

  • 日本薬学会   ファルマシア 連絡委員  

    2015年   

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    団体区分:学協会

    日本薬学会

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  • 日本薬学会   ファルマシア トピックス専門小委員  

    2009年 - 2011年   

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    団体区分:学協会

    日本薬学会

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  • 日本薬理学会   学術評議員  

    1999年   

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    団体区分:学協会

    日本薬理学会

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書籍等出版物

  • 小児科 特集 アレルギー疾患におけるステロイド薬の局所療法-作用メカニズムと使い方

    金原出版株式会社  2016年 

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  • Pediatrics of Japan

    2016年 

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  • 肥満細胞の臨床

    先端医学社  2001年 

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MISC

  • Involvement of glucocorticoid receptor activation on anti-inflammatory effect induced by peroxisome proliferator-activated receptor γ agonist in mice

    Atsuki Yamamoto, Hiroki Kakuta, Yukio Sugimoto

    Int. Immunopharmacol.22 ( 1 ) 204 - 208   2014年9月

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  • Genomic and non-genomic effects of glucocorticoids on allergic rhinitis model in mice

    Eriko Kusaka, Mayu Sugiyama, None Senoo, Atsuki Yamamoto, Yukio Sugimoto

    INTERNATIONAL IMMUNOPHARMACOLOGY16 ( 2 ) 279 - 287   2013年6月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Glucocorticoids (GCs) are well known for their anti-inflammatory effects, which are elicited through a transcriptional mechanism via a cytosolic glucocorticoid receptor (cGR)-mediated genomic effect. However, recent in vitro studies report that GCs can act as a membrane glucocorticoid receptor (mGR). This study aimed to examine whether mometasone furoate (MF) influences the nasal symptoms induced by histamine, substance P, ATP. Furthermore, the influences of various compounds on MF action were studied in vivo. The mice were intranasally administered with nasal symptom-inciting agents, and the occurrences of sneezing and nasal rubbing were counted. MF repressed the nasal symptoms caused when it was administered 10, 30 and 60 min before the induction of nasal symptoms. The repressive effect observed 10 min after the administration of MF was inhibited by RU486, a GR antagonist but not by actinomycin D, a transcriptional inhibitor. In contrast, the repressive effect observed 60 min after the administration of MF was inhibited by RU486 and actinomycin D. Therefore, the effects observed 10 and 60 min after the MF administration were classified as non-genomic and genomic effects, respectively. The non-genomic effect suppressed the nasal symptoms induced by m-3M3FBS, a phospholipase C (PLC) activator, and was inhibited by U-73122, a PLC inhibitor. The genomic effect was inhibited by N-(p-amylcinnamoyl) anthranilic acid, a phospholipase A(2) (PLA(2)) inhibitor. These results indicate that MF has a non-genomic effect through repression of the activation of PLC via the mGR, and MF has also a genomic effect that was influenced by the inhibition of PLA(2) through transcriptional regulation via cGR. (c) 2013 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.intimp.2013.03.030

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  • In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

    Hidekazu Ishimoto, Mari Shibata, Yuki Myojin, Hideyuki Ito, Yukio Sugimoto, Akihiro Tai, Tsutomu Hatano

    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS21 ( 19 ) 5901 - 5904   2011年10月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Urolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.bmcl.2011.07.086

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  • Prophylactic Effects of the Histamine H-1 Receptor Antagonist Epinastine and the Dual Thromboxane A(2) Receptor and Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells Antagonist Ramatroban on Allergic Rhinitis Model in Mice

    Yuh Suzuki, Toshio Inoue, Atsuki Yamamoto, Yukio Sugimoto

    BIOLOGICAL & PHARMACEUTICAL BULLETIN34 ( 4 ) 507 - 510   2011年4月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The prophylactic use of anti-allergic drugs has been proposed to be effective in the treatment of seasonal allergic rhinitis in humans. However, there is little information regarding the prophylactic effect of thromboxane A(2) (TXA(2)) receptor antagonist on allergic rhinitis. Recent studies revealed that a TXA(2) receptor antagonist ramatroban could block the prostaglandin D-2 (PGD(2)) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). In the present study, we investigated the prophylactic effects of the histamine H, receptor antagonist epinastine and the TXA(2) receptor antagonist ramatroban and seratrodast on mouse models of allergic rhinitis. Female BALB/c mice were sensitized by an intraperitoneal injection of ovalbumin and alum on days 0, 5, 14 and 21. Seven days later, mice were sensitized by intranasal application of ovalbumin thrice a week. Drugs were administered once a day from day 22. The severity of allergic rhinitis was assessed by determining the extent of 2 nasal allergic symptoms (sneezing and nasal rubbing). Histamine sensitivity and eosinophil infiltration into the nasal mucosa were also determined. Epinastine and ramatroban significantly reduced nasal symptoms and the number of eosinophils in the nasal mucosa. Seratrodast showed no effect on nasal symptoms and cosinophil infiltration into the nasal mucosa. In addition, histamine sensitivity was reduced by epinastine and ramatroban. These results indicate that epinastine and ramatroban induce the prophylactic effect on allergic rhinitis.

    DOI: 10.1248/bpb.34.507

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  • Involvement of the retinoid X receptor ligand in the anti-inflammatory effect induced by peroxisome proliferator-activated receptorγagonist In Vivo

    Atsuki Yamamoto, Hiroki Kakuta, Hiroyuki Miyachi, Yukio Sugimoto

    PPAR Research2011 ( 840194 ) 1 - 8   2011年

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  • Involvement of peripheral mu opioid receptors in scratching behavior in mice(共著)

    Atsuki Yamamoto, Yukio Sugimoto

    Eur. J. Pharmacol.649 ( 1-3 ) 336 - 341   2010年12月

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  • Effect of 5-aminosalicylate on allergic rhinitis model in mice (共著)

    Shoji Kuyama, Atsuki Yamamoto, Mayu Sugiyama, Hiroki Kakuta, Yukio Sugimoto

    Int. Immunopharmacol.10 ( 6 ) 713 - 716   2010年6月

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  • Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice(共著)

    Atsuki Yamamoto, Shoji Kuyama, Chiaki Kamei, Yukio Sugimoto

    Eur. J. Pharmacol.627 ( 1-3 ) 162 - 166   2010年2月

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  • Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation(共著)

    Zheng X, Oda H, Harada S, Sugimoto Y, Tai A, Sasaki K, Kakuta H

    J. Pharm. Sci.97 ( 12 ) 5446 - 5452   2008年12月

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  • Participation of histamine H3 receptors in experimental allergic rhinitis of mice(共著)

    Emiko Yokota, Shoji Kuyama, Yukio Sugimoto, Masami Ogawa, Chiaki Kamei

    J. Pharmcol. Sci.108 ( 2 ) 206 - 211   2008年10月

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  • Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor(共著)

    Kakuta H, Zheng X, Oda H, Harada S, Sugimoto Y, Sasaki K, Tai A

    J. Med. Chem.51 ( 8 ) 2400 - 2411   2008年4月

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  • Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors(共著)

    Zheng X, Oda H, Takamatsu K, Sugimoto Y, Tai A, Akaho E, Ali HI, Oshiki T, Kakuta H, Sasaki K

    Bioorg. Med. Chem.15 ( 2 ) 1014 - 1021   2007年1月

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  • Effect of paroxetine on marble-burying behavior in mice

    K Shinomiya, Y Fujii, Y Sugimoto, N Azuma, S Tokunaga, K Kitazumi, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY27 ( 10 ) 685 - 687   2005年12月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The present study was undertaken to investigate the effect of paroxetine, a selective serotonin reuptake inhibitor (SSRI). on marble-burying behavior in mice in comparison with those of fluvoamine and clomipramine. Marble-burying test is extensively used as an animal model for obsessive/compulsive disorder A significant inhibition in marble-burying behavior was observed with paroxetine, at a dose of,10 mg/kg. The earlier SSRI, fluvoxamine, also significantly inhibited marble-burying behavior at a dose of 30 mg/kg. Although clomipramine. a tricyclic antidepressant, caused an inhibition in marble-burying behavior, a high dose of 100 mg/kg was needed to show a significant effect. On the other hand. all the drugs used in the present study showed no significant changes in spontaneous locomotor activity at doses inhibiting marble-burying behavior. In conclusion, it was confirnied that paroxetine has a potent inhibitory effect on marble-burying behavior in mice, and could have a similar antiobsessive/ anticompulsive activity in hunan beings. (c) 2005 Prous Science. All rights reserved.

    DOI: 10.1358/mf.2005.27.10.948883

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  • Pruritus-associated response mediated by cutaneous histamine H-3 receptors

    Y Sugimoto, Y Iba, Y Nakamura, R Kayasuga, C Kamei

    CLINICAL AND EXPERIMENTAL ALLERGY34 ( 3 ) 456 - 459   2004年3月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING LTD  

    Background Histamine is one of the most common chemical mediators causing pruritus, and H-1 receptor antagonists have been used as a first choice in its treatment. On the other hand, although the presence of H-3 receptors has been identified in the skin, few studies have investigated the involvement of H-3 receptors on pruritus.
    Objective The purpose of this study was to examine whether H-3 receptor agonist or antagonist influences the incidence of scratching behaviour in ICR or mast cell-deficient WBB6F(1)-W/W-V mice.
    Methods The mice were given an intradermal injection of H-3 receptor agonist or antagonist into the rostral part of the back, and the occurrence of scratching behaviour at the injected site by the hind paws was counted over 60 min.
    Results H-3 receptor antagonists, thioperamide and AQ0145 significantly increased the incidence of scratching behaviour in ICR mice. H-3 receptor agonist, (R)-alpha-methylhistamine, had no effect. On the other hand, (R)-alpha-methylhistamine significantly inhibited thioperamide or AQ0145-induced scratching behaviour. In addition, both thioperamide and AQ0145 elicited scratching behaviour in mast cell-deficient WBB6F(1)-W/W-V mice.
    Conclusion From these results, it may be concluded that H-3 receptors are involved in the modulation of pruritus in the skin, and mast cells are not essential in this response. In addition, H-3 receptor agonists can be useful as a novel therapeutic approach against pruritus.

    DOI: 10.1111/j.1365-2222.2004.01876.x

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  • Histamine H-3 receptors regulate vascular permeability changes in the skin of mast cell-deficient mice

    MA Hossen, Y Fujii, Y Sugimoto, R Kayasuga, C Kamei

    INTERNATIONAL IMMUNOPHARMACOLOGY3 ( 12 ) 1563 - 1568   2003年11月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The participation of histamine H-3 receptors in the regulation of skin vascular permeability changes in mast cell-deficient mice was studied. Although intradermal injection of histamine H-3 antagonists, iodophenpropit and clobenpropit, at a dose of 100 nmol/site caused significant increases in skin vascular permeability in both mast cell-deficient (WBB6F1 W/W-v) and wildtype (WBB6F1 +/+) mice, this response was significantly lower in mast cell-deficient mice than in the wild-type controls. Histamine also caused dose-related increases in skin vascular permeability in both wild-type and mast cell-deficient mice. Significant effects were observed at doses of 10 and 100 nmol/site, and no significant difference in skin vascular permeability was observed between mast cell-deficient and wild-type mice. However, histamine contents of dorsal skin in mast cell-deficient mice were significantly lower than in wild-type mice. In addition, the H, antagonists diphenhydramine and chlorpheniramine and the NK1 antagonists, L-732,13 8 and L-733,060, were able to antagonize H-3 antagonist-induced skin vascular permeability. These results indicated that blockade of H-3 receptors by H-3 antagonists induce skin vascular permeability through mast cell-dependent mechanisms. In addition, histamine and, to a lesser extent substance P are involved in the reaction. (C) 2003 Published by Elsevier B.V.

    DOI: 10.1016/S1567-5769(03)00009-2

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  • Involvement of histamine H-3 receptors in scratching behaviour in mast cell-deficient mice

    MA Hossen, Y Sugimoto, R Kayasuga, C Kamei

    BRITISH JOURNAL OF DERMATOLOGY149 ( 1 ) 17 - 22   2003年7月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING LTD  

    Background Although the roles of histamine H-3 receptors have been studied in several tissues such as the brain, lung, spleen, colon and peripheral sensory nerve endings, the involvement of H-3 receptors in skin responses particularly in relation to scratching behaviour are not well documented.
    Objectives This work was performed to study the effects of histamine H-3 antagonists on scratching behaviour in mast cell-deficient mice.
    Methods Histamine H-3 antagonists iodophenpropit and clobenpropit, histamine and substance P were injected intradermally into the rostral part of the back of mast cell-deficient (WBB6F1 W/W-v ) and wild-type (WBB6F1+/+) mice and scratching behaviour was measured for 60 min. The effects of H-1 antagonists on scratching behaviour induced by H-3 antagonists were also investigated.
    Results Intradermal injection of iodophenpropit and clobenpropit at doses of 10 and 100 nmol per site caused significant increases in scratching behaviour in both mast cell-deficient and wild-type mice. Histamine also caused a dose-related increase in the incidence of scratching behaviour, and a significant effect was observed at a dose of 100 nmol per site in both mast cell-deficient and wild-type mice. Substance P was also effective in causing scratching behaviour in both mast cell-deficient and wild-type mice. However, histamine H-1 antagonists diphenhydramine and chlorphenamine failed to inhibit H-3 antagonist-induced scratching behaviour in both types of mice.
    Conclusions Our results indicated that intradermal injection of H-3 antagonists induces scratching behaviour and that chemical mediators other than histamine seem to be involved in the response.

    DOI: 10.1046/j.1365-2133.2003.05341.x

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  • Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis

    Y Sugimoto, M Ogawa, N Tai, C Kamei

    INTERNATIONAL IMMUNOPHARMACOLOGY3 ( 6 ) 845 - 852   2003年6月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Eosinophil infiltration into inflammatory tissues and the subsequent release of inflammatory mediators are the hallmarks of several inflammatory allergic diseases. Although there have been a considerable number of publications on anti-inflammatory effects of glucocorticoids, little is known about whether glucocorticoids affect the activation of eosinophils directly. We studied the effects of three glucocorticoids, mometasone furoate, dexamethasone and beclomethasone dipropionate, on superoxide generation and the chemotaxis of rat eosinophils. Highly purified rat eosinophils were treated for 6 h with mometasone furoate, dexamethasone or beclomethasone dipropionate. Eosinophils were stimulated with phorbol myristate acetate (PMA) for superoxide generation, while for induction of chemotaxis, platelet-activating factor (PAF) or leukotriene B-4 (LTB4) was used. None of the glucocorticoids used in the present study caused significant suppressive effects on superoxide generation induced by PMA. On the other hand, both PAF- and LTB4-induced migration of rat eosinophils were inhibited in a concentration-dependent manner by glucocorticoids. Mometasone furoate showed a significant effect at concentrations higher than 10(-11) M. Dexamethasone and beclomethasone dipropionate also caused a significant inhibition at concentrations higher than 10(-8) and 10(-7) M, respectively These results indicated that the anti-inflammatory effects of glucocorticoids were mediated by direct inhibition of eosinophil migration. Furthermore, mometasone furoate was suggested to be more useful than the other drugs in the treatment of allergic diseases responsible for eosinophil chemotaxis. (C) 2003 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S1567-5769(03)00055-9

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  • Evaluation of the effects of anti-pruritic drugs on scratch responses using histamine H-1 receptor-deficient mice

    Y Sugimoto, Y Nakamura, MA Hossen, T Watanabe, C Kamei

    EUROPEAN JOURNAL OF PHARMACOLOGY470 ( 1-2 ) 113 - 116   2003年5月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The effects of anti-pruritic drugs on scratching behavior associated with passive cutaneous anaphylaxis in histamine H-1 receptor-deficient and wild-type mice were studied. Passive sensitization with mouse monoclonal anti-dinitrophenyl-immunoglobulin E (IgE) resulted in an increase in the incidence of scratching behavior induced by intravenous injection of dinitrophenyl-ovalbumin in both wild-type and histamine H-1 receptor-deficient mice. The histamine H-1 receptor antagonist diphenhydramine inhibited scratching behavior induced by antigen in passively sensitized wild-type mice, whereas no effect was observed in histamine H-1 receptor-deficient mice. On the other hand, oxatomide inhibited scratching behavior in both mice, although the effect in wild-type mice was more potent than that in histamine H-1 receptor-deficient mice. Tranilast inhibited scratching behavior with the same potency in both mice. We concluded that the scratching behavior associated with passive cutaneous anaphylaxis involves not only histamine H-1 receptors but also other chemical mediators. Furthermore, the results of the present study indicated that oxatomide has an antagonistic effect on histamine H-1 receptors as well as anti-pruritic effect in vivo. (C) 2003 Elsevier Science B.V All rights reserved.

    DOI: 10.1016/S0014-2999(03)01786-2

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  • Effects of [Arg(8)]-vasopressin on regional cerebral blood flow in spontaneously hypertensive rats

    A Azuma, Y Sugimoto, M Mio, K Shinomiya, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY25 ( 3 ) 193 - 197   2003年4月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The effects of [Arg(8)]-vasopressin (AVP) and related compounds on regional cerebral blood flow (rCBF) in the hippocampus were studied using conscious spontaneously hypertensive rats (SHR). rCBF in the hippocampus decreased gradually with age in proportion to an increase in mean blood pressure. Subcutaneous injection of AVP caused a dose-dependent increase in rCBF in the hippocamous. The effects of the metabolic fragments AVP4-9 and A VP4-8 on rCBF were relatively weak. OPC-31260, a vasopressin V-2 antagonist, antagonized the AVP-induced increase in rCBF in the hippocampus. Furthermore, subcutaneous injection of DDAVP, a V-2 agonist, increased rCBF in the hippocampus. On the other hand, the AVP-induced increase in rCBF in the hippocampus was not antagonized by OPC-21268, a vasopressin V-1 antagonist. Intracerebroventricular injection of AVP caused no significant changes in rCBF in the hippocampus, even at a dose of 10 ng/site. (C) 2003 Prous Science. All rights reserved.

    DOI: 10.1358/mf.2003.25.3.769639

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  • Possible role of mucosal mast cells in the recovery process of colitis induced by dextran sulfate sodium in rats

    Y Iba, Y Sugimoto, C Kamei, T Masukawa

    INTERNATIONAL IMMUNOPHARMACOLOGY3 ( 4 ) 485 - 491   2003年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    To clarify the role of mucosal mast cells in the lesion sites of colitis induced by dextran sulfate sodium (DSS) in rats, we investigated the histological changes and alterations relevant to mucosal mast cells in the spontaneous recovery process of colitis. Oral administration of 4% DSS solution for 11 days resulted in surface epithelial loss, crypt loss and goblet cell depletion in the rectal mucosa. A marked infiltration of inflammatory cells into the mucosa, which was consistent with a significant increase in myeloperoxidase (MPO) activity, was observed. In addition, mucosal mast cell number and rat mast cell protease (RMCP) I and H levels in the rectum increased at day 0 after DSS treatment, and most of the mucosal mast cells were degranulated. After replacing 4% DSS solution with water, re-epithelialization and restoration of goblet cells were observed at day 5 and day 10, respectively, but crypt damage was hardly recovered even at day 20. The elevated myeloperoxidase activity was significantly decreased from day 5 after DSS treatment. The increased number of mucosal mast cells was further elevated up to about 1.5-fold at day 10 and day 20 after DSS treatment and little degranulation was observed. In the spontaneous recovery process, the increased rat mast cell protease H level in the rectum was maintained for 20 days, while the increased rat mast cell protease I level was gradually decreased and recovered to control level. These results suggest that proliferated mucosal mast cells remained for 20 days, although most of infiltrated inflammatory cells disappeared in spontaneous recovery process of colitis. It may therefore be presumed that proliferated mucosal mast cells play a role in spontaneous recovery process of the colitis induced by DSS. (C) 2003 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S1567-5769(02)00299-0

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  • Inhibitory effects of propolis granular A. P. C on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice

    Y Sugimoto, Y Iba, R Kayasuga, Y Kirino, M Nishiga, MA Hossen, K Okihara, H Sugimoto, H Yamada, C Kamei

    CANCER LETTERS193 ( 2 ) 155 - 159   2003年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCI IRELAND LTD  

    We examined the effect of propolis granular A. P. C on lung tumorigenesis in female A/J mice. Lung tumors were induced by the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) administered in drinking water for 7 weeks in mice maintained on an AIN-76A semi-synthetic diet. Propolis granular A. P. C (100 mg/kg body wt.) was administered orally daily for 6 days/week from I week before NNK administration and throughout the experiment. Sixteen weeks after the NNK treatment, the mice were killed and the number of surface lung tumors was measured. The number of lung tumors in mice treated with NNK alone for 7 weeks (9.4 mg/mouse) was significantly more than in that observed in control mice. Propolis granular A. P. C significantly decreased the number of lung tumors induced by NNK. These results indicate that propolis granular A. P. C is effective in suppressing NNK-induced lung tumorigenesis in mice. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

    DOI: 10.1016/S0304-3835(03)00016-8

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  • Effects of NMDA antagonist MK-801 on radial maze performance in Zucker rats

    M Nishiga, Y Fujii, Y Sugimoto, M Konishi, C Kamei

    BRAIN RESEARCH950 ( 1-2 ) 127 - 129   2002年9月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    We examined the participation of the NMDA receptor in the histaminergic system using radial maze performance in Zucker rats. Although pyrilamine caused a significant effect on spatial memory deficit in lean rats, no significant spatial memory deficit was observed in obese rats. On the other hand, MK-801 caused significant spatial memory deficits in obese rats in comparison with lean rats. These results indicate that the histaminergic neuron is not closely related with the radial maze performance in obese rats. In addition, the potent effect of MK-801 observed in obese rats compared with lean rats may be responsible for the activation of NMDA receptors in obese rats. (C) 2002 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0006-8993(02)03012-3

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  • Effect of docosahexaenoic acid-fortified Chlorella vulgaris strain CK22 on the radial maze performance in aged mice

    Y Sugimoto, C Taga, M Nishiga, M Fujwara, F Konishi, K Tanaka, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN25 ( 8 ) 1090 - 1092   2002年8月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Effect of docosahexaenoic acid (DHA) [22:6(n-3)]-fortified Chlorella oil fraction on radial maze performance was studied in aged mice. Male ICR mice aged 9 months were fed a diet containing 2 g DHA-fortified Chlorella oil fraction/100 g diet or normal diet (Control group) for 2 months. Two months after the start of feeding, the mice were tested for learning ability related to 2 types of memory, reference memory and working memory, with the partially (4 of 8) baited eight-arm radial maze. Reference memory is a kind of information that should be retained until the next trial. Working memory is a kind of information that disappears in a short time. Entry into the unbaited arms and repeated entry into the visited arms were defined as reference memory errors and working memory errors, respectively. DHA-fortified Chlorella oil fraction administration to mice for 2 months resulted in a significant decrease in the number of working memory errors without affecting the number of reference memory errors. A significant increase in the DHA content in the brain was also observed. These results suggest that the intake of DHA-fortified Chlorella oil fraction effectively enhances working memory in maze performance.

    DOI: 10.1248/bpb.25.1090

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  • Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H-1 receptors

    R Kayasuga, Y Sugimoto, T Watanabe, C Kamei

    EUROPEAN JOURNAL OF PHARMACOLOGY449 ( 3 ) 287 - 291   2002年8月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The purpose of this study was to investigate the involvement of chemical mediators other than histamine in nasal allergic signs using histamine H-1 receptor-deficient mice. In passively sensitized mice, antigen instillation into the nasal cavity induced significant increases in sneezing and nasal rubbing in wild-type mice, but no such increases were observed in histamine H-1 receptor-deficient mice. In actively sensitized mice, both sneezing and nasal rubbing were also significantly increased in a dose-dependent manner in both wild-type and histamine H-1 receptor-deficient mice. Histamine H-1 receptor antagonists such as cetirizine and epinastine significantly inhibited antigen-induced nasal allergic signs in wild-type mice, although the effects were incomplete. In addition, the thromboxane A(2) receptor antagonist ramatroban also inhibited these responses in wild-type mice. However, the leukotriene receptor antagonist zafirlukast showed no effects in wild-type mice. These results suggested that in the acute allergic model (passive sensitization), only histamine H-1 receptors are related to nasal signs induced by antigen, whereas in the chronic allergic model (active sensitization), both histamine H-1 receptors and thromboxane A(2) receptors were involved in the responses. (C) 2002 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0014-2999(02)02005-8

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  • Changes in membrane potential induced by compound 48/80 in the peritoneal mast cells of rats

    Y Nakayama, M Mio, Y Sugimoto, Y Fujii, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY24 ( 5 ) 267 - 273   2002年6月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The changes in membrane potential induced by, compound 48/80 were studied using rat peritoneal mast cells, The mean resting membrane potential of rat mast cells was -12.3 +/- 0.7 mM. When compound 48/80 was added to the mast cells, the cells were degranulated approximately 120 sec after the addition of the drug, after which immediate depolarization occurred. Degranulation of mast cells was not observed, even under the depolarization or hyperpolarization conditions caused by the replacement of a high K+ medium or the removal of K+ from the medium, respectively Under both conditions, when compound 48/80 was added to the mast cells, degranulation was observed. Abrupt and marked-depolarization was induced 30-60 sec after compound 48/80 was added. In addition, repolarization followed by gradual depolarization was observed without degranulation in mast cells treated with cytochalasin D after the addition of compound 48/80. These results suggest that the mast cells were depolarized by compound 48/80 independently of degranulation. It is also feasible that the gradual depolarization and repolarization induced by compound 48/80 in mast cells pretreated with cytochalasin D participated in the extracellular Na+ and Na+/K+-pump, respectively. (C) 2002 Prous Science. All rights reserved.

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  • Histamine H-1 receptors are involved in mouse nasal allergic responses: a demonstration with H-1 receptor-deficient mice

    R Kayasuga, Y Sugimoto, T Watanabe, C Kamei

    INTERNATIONAL IMMUNOPHARMACOLOGY2 ( 6 ) 745 - 750   2002年5月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The role of histamine H-1 receptors in nasal allergic symptoms (sneezing and nasal rubbing) were studied using histamine H-1 receptor-deficient mice. Intranasal instillation of histamine solution resulted in significant increases in sneezing and nasal rubbing in wild-type mice, whereas no increases were observed in histamine H-1 receptor-deficient mice. The histamine H-1 receptor agonist 2-pyridylethylamine induced sneezing and nasal rubbing in a dose-dependent manner in wild-type mice, but no such increase was fund in histamine H, receptor-deficient mice. On the other hand, the histamine H-2 receptor agonist dimaprit did not increase sneezing and nasal rubbing in wild-type mice. Histamine H-1 receptor antagonists such as chlorpheniramine and epinastine significantly inhibited nasal allergic symptoms caused by histamine, but the histamine H-2 receptor antagonists cimetidine and famotidine showed no effect. No additional effects were observed by combined use of chlorpheniramine and cimetidine or famotidine compared with cimetidine or famotidine alone. These results suggested that histamine H, receptors play an important role in nasal allergy symptoms induced by histamine. (C) 2002 Elsevier Science B.V All rights reserved.

    DOI: 10.1016/S1567-5769(02)00010-3

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  • Effects of the NMDA antagonist MK-801 on radial maze performance in histidine-deficient rats

    M Nishiga, Y Sugimoto, C Taga, Y Fujii, C Kamei

    LIFE SCIENCES70 ( 18 ) 2199 - 2208   2002年3月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We examined the effects of a histidine-deficient diet on brain histamine contents as well as on learning and memory using the eight-ann radial maze in rats. A significant decrease in histamine content in the hippocampus was observed after long-term feeding of rats with a histidine-deficient diet. At the same time, significant enhancement of the acquisition process in radial maze performance was also observed. Pyrilamine did not show a significant effect on radial maze performance in histidine-deficient rats. On the other hand, pyrilamine caused a significant spatial memory deficit in control rats. Scopolamine was effective in inhibiting spatial memory in both histidine-deficient and control rats. MK-801 caused spatial memory deficits more potently in histidine-deficient rats than in controls. Brain glycine contents showed a significant increase in the hippocampus in histidine-deficient rats. These results indicated that the spatial memory deficits induced by MK-801 in histidine-deficient rats are closely related to increased glycine levels and activation of NMDA receptors. (C) 2002 Elsevier Science Inc. All rights reserved.

    DOI: 10.1016/S0024-3205(02)01504-7

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  • Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L.

    T Inoue, Y Sugimoto, H Masuda, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN25 ( 2 ) 256 - 259   2002年2月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Six flavonoid glycosides, eriocitrin (1), narirutin (2), hesperidin (3), luteolin-7-O-rutinoside (4), isorhoifolin (5), diosmin (6), rosmarinic acid (7) and 5,7-dihydroxycromone-7-O-rutinoside (8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses of 100 and 300 mg/kg. These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.

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  • Participation of mast cells in colitis inflammation induced by dextran sulfate sodium

    Y Iba, Y Sugimoto, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY24 ( 1 ) 15 - 18   2002年1月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    We investigated the participation of mast cells in colitis inflammation induced by dextran sulfate sodium (DSS). The damage score and myeloperoxidase (MPO) activity were measured to confirm the occurrence of colitis. Rat mast cell protease (RMPCP) II levels in the serum were estimated as an index of mast cell degranulation. Tissue RMCP I and RMCP II levels in the rectum were also measured as markers of the numbers of connective tissue mast cells (CTMCs) and mucosal mast cells (MMCs), respectively. Administration of 4% DSS resulted in time-related increases in damage score. MPO activity and serum RMCP II levels, which were statistically significant at 7 and 11 days after treatment. Tissue RMCP I and RMCP II levels in the rectum were also increased significantly at 7 and 11 days, and 11 days, respectively after free drinking of 4% DSS. These results suggested that mast cells proliferated or the amount of protease per mast cell increased in the sites of inflammation induced by DSS, and that these mast cells may modulate the disorders observed in DSS-induced colitis. (C) 2002 Prous Science. All rights reserved.

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  • ラットのアレルギー性結膜炎に対する塩酸レボカバスチンの効果

    Kazuhisa Minami, Yukio Sugimoto, Chiaki Kamei

    J. Eye19 ( 6 ) 787 - 791   2002年

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  • Effect of levocabastine hydrochloride on allergic conjunctivitis in rats

      19 ( 6 ) 787 - 791   2002年

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  • Effects of histidine on working memory deficits induced by the 5-HT1A-receptor agonist 8-OH-DPAT

    S Isayama, Y Sugimoto, M Nishiga, C Kamei

    JAPANESE JOURNAL OF PHARMACOLOGY86 ( 4 ) 451 - 453   2001年8月

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    記述言語:英語   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    We investigated the effects of histidine on spatial memory deficits induced by the 5-HT1A-receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetratin (8-OH-DPAT). Working memory deficits were elicited by 8-OH-DPAT without affecting reference memory. Histidine improved the working memory deficit induced by 8-OH-DPAT at doses causing a significant increase in brain histamine content. This finding suggests that the histaminergic system regulates 8-OH-DPAT-induced working memory deficit.

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  • Effects of vasopressin on histamine H-1 receptor antagonist-induced spatial memory deficits in rats

    C Taga, Y Sugimoto, M Nishiga, Y Fujii, C Kamei

    EUROPEAN JOURNAL OF PHARMACOLOGY423 ( 2-3 ) 167 - 170   2001年7月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The effects of [Arg(8)] vasopressin on histamine H-1 receptor antagonist-induced memory deficits were investigated using the eight-arm radial maize performance test in rats. Pyrilamine and diphenhydramine as well as scopolamine induced memory deficits characterized by increaser in the number of total errors, reference memory errors and working memory errors. [Arg(8)] vasopressin improved not only scopolamine-but also pyrilamine-and diphenhydramine-induced memory deficits, although a high dose of [Arg(8)] vasopressin was needed to antagonize pyrilamine-induced memory deficits. The effects of pyrilamine on the brain [Arg(8)] vasopressin content were studied, and the hippocampus [Arg(8)] vasopressin content was shown to be decreased after pyrilamine injection. From these observations, it seems likely that [Arg(8)] vasopressin participates in not only the cholinergic system but also the histaminergic system in spatial memory. (C) 2001 Elsevier Science B.V. All rights reserved.

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  • Effects of peppermint (Mentha piperita L.) extracts on experimental allergic rhinitis in rats

    T Inoue, Y Sugimoto, H Masuda, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN24 ( 1 ) 92 - 95   2001年1月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The present study,vas carried out to clarify the effects of extracts of the leaves of Mentha piperita L. on experimental allergic rhinitis. The 50% EtOH extract of peppermint inhibited histamine release from rat peritoneal mast cells induced by compound 48/80. The effect was dose-dependent and significant inhibition was observed at a concentration of 3 mug/ml. In addition, the 50% EtOH eluate separated from the 50% EtOH extract of peppermint by column chromatography (DIAION HP-20) was also effective in inhibiting histamine release at a concentration of 1 mug/ml. Nasal symptoms, sneezing and nasal rubbing induced by antigen challenge in actively sensitized rats were inhibited by oral administration of the 50% EtOH eluate. Significant inhibition of sneezing and nasal rubbing was observed at doses of 300 and 1000 mg/kg, p.o., respectively: Furthermore, the 50% EtOH eluate inhibited die leakage into the nasal cavity of rats induced by antigen in a dose-dependent manner. These results suggested that extracts of Mentha piperita L. may be clinically effective in alleviating the nasal symptoms of allergic rhinitis.

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  • Involvement of mast cells on ulcerative colitis model in rats

      22 ( Suppl. 1 ) S144-S150   2001年

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  • ラット潰瘍性大腸炎モデルにおける肥満細胞の関与

    杉本幸雄, 亀井千晃

    Ther. Res.22 ( Suppl. 1 ) S144-S150   2001年

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  • Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats

    C Kamei, M Ohuchi, Y Sugimoto, C Okuma

    BRAIN RESEARCH887 ( 1 ) 183 - 186   2000年12月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    In the present study, we have demonstrated that multiple first-generation H1-antagonists caused behavioral and EEG seizures in rats. The epileptogenic property of pyrilamine was more potent than either chlorpheniramine or diphenhydramine. In contrast, the second-generation H1-antagonists, loratadine and ebastine did not induce detectable epileptogenic activity. Intraperitoneal injection of histidine inhibited the EEG seizures induced by pyrilamine, diphenhydramine or chlorpheniramine; however no antagonism was observed with physostigmine. These results clearly suggest that the epileptogenic activity of first-generation H1-antagonists is dependent upon a centrally acting histaminergic mechanism. (C) 2000 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0006-8993(00)03041-9

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  • Vascular permeability in allergic conjunctivitis in mice lacking histamine H-1 receptors

    H Nakahara, K Izushi, Y Sugimoto, T Watanabe, C Kamei

    EUROPEAN JOURNAL OF PHARMACOLOGY409 ( 3 ) 313 - 317   2000年12月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    To clarify the role of histamine H-1 receptors in allergic conjunctivitis, changes in vascular permeability of the conjunctiva were measured in histamine H-1 receptor deficient mice. Wild-type mice showed a significant increase in vascular permeability of the conjunctiva induced by histamine. However, no such increase was found in histamine H-1 receptor deficient mice. On the other hand, no differences were observed between wild-type and histamine H-1 receptor deficient mice in response to serotonin. A significant increase in vascular permeability was observed in actively sensitized wild-type mice, whereas no increase was observed in histamine H-1 receptor deficient mice. Similar findings were noted in passively sensitized animals. Histamine contents of the conjunctiva were significantly decreased by topical application of antigen in both wild-type and histamine H-1 receptor deficient mice after active sensitization with antigen. These findings suggested that vascular permeability in the conjunctiva in allergic conjunctivitis is entirely regulated through histamine H-1 receptor. (C) 2000 Elsevier Science B.V. All rights reserved.

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  • Effects of Fujibitol, a remedy for nasal symptoms, on experimental allergic rhinitis in rats

    M Kakimoto, Y Sugimoto, M Harada, Y Kobayashi, C Okuma, C Taga, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN23 ( 9 ) 1055 - 1058   2000年9月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The effects of Fujibitol, a preparation of crude drugs in wide clinical use for treatment of chronic rhinitis and empyema, on experimental allergic rhinitis in rats were studied. Fujibitol inhibited nasal allergic symptoms, Le. sneezing and nasal rubbing, induced by antigen in sensitized animals. An increase in dye leakage into the nasal cavity induced by antigen was also inhibited by Fujibitol. On the other hand, no inhibitory effects were observed on either the nasal allergic symptoms or increase in dye leakage into the nasal cavity induced by histamine. However, Fujibitol was effective in inhibiting histamine release from the nasal cavity induced by antigen. Oxatomide used as positive control drug showed potent inhibitory effects on nasal symptoms and dye leakage into the nasal cavity induced by histamine and antigen. These results suggested that Fujibitol showed a remarkable protective effect against experimental rhinitis induced by antigen via inhibition of histamine release from the nasal cavity.

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  • A new model of allergic rhinitis in rats by topical sensitization and evaluation of H-1-receptor antagonists

    Y Sugimoto, E Kawamoto, Z Chen, C Kamei

    IMMUNOPHARMACOLOGY48 ( 1 ) 1 - 7   2000年6月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    An animal model of chronic allergic rhinitis was developed by repeated local booster sensitization into the nasal cavity in sensitized rats. The severity of allergic rhinitis was assessed by determining the extent of two markers of nasal allergic symptoms (sneezing and nasal rubbing) after antigen challenge. The number of incidents of sneezing and nasal rubbing was markedly increased during intranasal instillation of antigen in sensitized rats. The PCA titers were also markedly elevated by intranasal sensitization. Some histamine H-1-receptor antagonists such as chlorpheniramine, ketotifen, astemizole and epinastine inhibited the increase in antigen-induced nasal symptoms in a dose-related manner. Nasal rubbing was more potently inhibited by H-1-receptor antagonists than sneezing.
    In conclusion, we developed a chronic allergic rhinitis model showing nasal symptoms in rats, and this model may be useful for evaluating the effects of drugs on allergic rhinitis. (C) 2000 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0162-3109(00)00173-9

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  • Experimental allergic conjunctivitis in guinea pigs induced by Japanese cedar pollen

    M Takada, T Yamada, H Nakahara, Y Sugimoto, K Izushi, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN23 ( 5 ) 566 - 569   2000年5月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    We report a new experimental allergic conjunctivitis with Japanese cedar pollen as antigen in guinea pigs, and the immunological characteristics of this model were also elucidated. Allergic conjunctivitis was developed by immunization in guinea pigs with a mixture containing Japanese cedar pollen and killed Bordetella pertussis. When local application of Japanese cedar pollen suspension 14 d after systemic immunization was performed every 3 d, remarkable conjunctivitis was observed from 20 to 35 d. Increase in vascular permeability and decrease in histamine contents of the conjunctiva were also observed after local application of antigen. Passive cutaneous anaphylactic (PCA) reactions revealed that both IgG- and IgE-rich antibodies were produced in this model. Chlorpheniramine, ketotifen and levocabastine were effective in inhibiting cedar pollen-induced conjunctivitis. Although a high concentration was needed, tranilast and amlexanox also showed significant inhibition of conjunctivitis induced by cedar pollen.

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  • The mechanism responsible for the drowsiness caused by first generation H-1 antagonists on the EEG pattern

    Y Kaneko, K Shimada, K Saitou, Y Sugimoto, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY22 ( 3 ) 163 - 168   2000年4月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The present study was performed to clarify the mechanism responsible for the drowsiness caused by first generation H-1 antagonists according to electroencephalogram activity. All H-1 antagonists used on the present study caused the EEG-recorded drowsiness pattern, i.e., increases in EEG power spectra of the delta and theta bands at the frontal cortex in rats. The potency of cyproheptadine was greater than those of diphenydramine and promethazine, while that of pyrilamine was less than those of the other drugs examined. The increase in EEG power spectra in the delta band induced by H-1 antagonists was antagonized by pretreatment with both histidine and physostigime. The effect of pyrilamine was more potently antagonized by histidine and less potently antagonized by physostigmine as compared to diphenylhydramine, promethazine and cyproheptadine. The increases in EEG power spectra induced by H-1 antagonists were neither antagonized nor potentiated by 5-hydroxytryptophan. These results clearly indicate that the increases in EEG power spectra in the delta and theta bands at the frontal cortex in rats induced by first generation H-1 antagonists are responsible for both histaminergic and cholingeric mechanisms. (C) 2000 Prous Science. All rights reserved.

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  • Effects of metabolic fragments of [Arg(8)]-vasopressin on nerve growth in cultured hippocampal neurons

    T Tarumi, Y Sugimoto, Z Chen, Q Zhao, C Kamei

    BRAIN RESEARCH BULLETIN51 ( 5 ) 407 - 411   2000年3月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    The effects of metabolic fragments of [Arg(8)]-vasopressin (AVP), [pGlu(4), Cyt(6)]AVP (AVP(4-9)), and desglycinamide-[pGlu(4), Cyt(6)]AVP (AVP(4-8)) on the growth of hippocampal neurons in culture were investigated in comparison with those of AVP. AVP(4-9) caused a significant increase in filopodial length following 96 h of exposure at concentrations higher than 300 nM. AVP(4-9) was more potent than AVP. AVP(4-8) also induced an increase in filopodial length, but this effect was less than that of AVP. The selective V-1 agonist [Phe(2), Ile(3), Orn(8)]-vasopressin caused a significant increase in filopodial length, whereas the selective V-2 agonist [deamino-Cys(1), D-Arg(8)]-vasopressin showed no such effect. OPC-21268, a vasopressin V-1 antagonist, blocked AVP and AVP fragment-induced increases in filopodial length. However, the V-2 antagonist OPC-31260 showed no such effect. A23187, a representative Ca ionophore, also increased filopodial length, and the A23187-induced increase in filopodial length was potentiated by AVP and AVP fragments. These results indicated that AVP(4-9) and AVP(4-8) increased filopodial length in cultured hippocampal neurons by activating V-1 receptors. Both phenomena induced by AVP(4-9) and AVP(4-8) were associated with intracellular calcium mobilization. (C) 2000 Elsevier Science Inc.

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  • Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures

    K Ishizawa, Z Chen, C Okuma, Y Sugimoto, Y Fujii, C Kamei

    JAPANESE JOURNAL OF PHARMACOLOGY82 ( 1 ) 48 - 53   2000年1月

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    記述言語:英語   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures. I.p. injection of clobenpropit caused dose-dependent inhibition of amygdaloid kindled seizures. GABAmimetic drugs such as diazepam, sodium valproate and muscimol also inhibited amygdaloid kindled seizures in a dose-dependent manner. Diazepam at doses of 0.2 and 0.5 mg/kg, which showed no significant effect on amygdaloid kindled seizures when used separately, significantly potentiated the effect of clobenpropit. Similar findings were observed with sodium valproate and muscimol at doses of 100 mg/kg and 5 ng, respectively, although neither showed any significant effects when administered separately. Bicuculline caused significant antagonism of the inhibition of amygdaloid kindled seizures induced by clobenpropit, while the effect of diazepam was not antagonized by diphenhydramine. These results suggested that inhibition of amygdaloid kindled seizures induced by histamine is closely associated with the actions of GABA.

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  • Brown-Norway系ラットを用いた潰瘍性大腸炎モデルの作製

    杉本幸雄, 亀井千晃

    Ther. Res.21 ( Suppl. 1 ) S217-S222   2000年

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  • Effect of mometasone furoate by topical application on allergic rhinitis model in rats

    Y Sugimoto, K Ishizawa, K Saitou, G Suzuki, T Tarumi, H Nakahara, Y Kirino, C Kamei

    PHARMACOLOGY61 ( 2 ) 91 - 95   2000年

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    記述言語:英語   出版者・発行元:KARGER  

    The effects of mometasone furoate on experimental allergic rhinitis in rats were studied in comparison with that of fluticasone propionate. Topical application of both drugs inhibited dose-dependently the increase of nasal symptoms (sneezing and nasal rubbing) after antigen challenge to the nasal cavity of actively sensitized rats. Mometasone furoate and fluticasone propionate at concentrations of 0.01 or 0.1% significantly inhibited both nasal rubbing and sneezing 1 h after topical application of both drugs. The relative potencies of mometasone furoate in nasal rubbing and sneezing compared to fluticasone propionate were 5.01 and 6.87, respectively. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibited the increase of antigen-induced nasal rubbing even 6 h after topical application, indicating that both drugs have a long-lasting effect. Copyright (C) 2000 S. Karger AG, Basel.

    DOI: 10.1159/000028386

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  • A new model of ulcerative colitis in Brown-Norway rats.

      21 ( Suppl. 1 ) S217-S222   2000年

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  • Influences of everninomicin ,vancomycin and teicoplanin on chemical mediator release form rat peritoneal mast cells.

    Yukio Sugimoto, Yoshinori Iba, Keiko Utsugi, Chiaki Kamei

    Jpn. J. Pharmacol.83 ( 4 ) 300 - 305   2000年

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  • Effect of propolis extract on D-galactosamine-induced hepatic injury in rats

    Y Sugimoto, T Tarumi, Y Kaneko, S Isayama, N Kawai, H Sugimoto, H Yamada, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN22 ( 11 ) 1237 - 1239   1999年11月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The preventive effect of propolis extract on D-galactosamine-induced hepatic injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly increased at 24 h after intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h and 1 h before and 8 h after D-galactosamine injection. The extract itself and the vehicle alone (dextran) caused no significant changes in serum AST or ALT activities. Treatment with the extract dose-dependently prevented the increases in serum AST and ALT activities induced by D-galactosamine, and significant inhibition was observed at a dose of 30 mg/kg. These results suggested that propolis extract may have an ameliorating effect on hepatic dysfunction.

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  • Effects of intracerebroventricular injection of α-fluoromethylhistidine on radial maze performance in rats.

    Zhong Chen, Yukio Sugimoto, Chiaki Kamei

    Pharmacol.Biochem.Behav.64 ( 3 ) 513 - 518   1999年11月

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  • Effects of histamine and related compounds on regional cerebral blood flow in rats

    G Suzuki, Z Chen, Sugimoto, I, Y Fujii, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY21 ( 9 ) 613 - 617   1999年11月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The effects of histamine and related compounds on regional cerebral bloodflow (rCBF) in the hippocampus of conscious rats were studied. Intracerebroventricular injection of histamine caused a dose-dependent increase in rCBF in the hippocampus, and similar findings were observed with not only the H-1 agonist, 2-thiazolylethylamine, but also the H-2 agonist, dimaprit. Intraperitoneal injection of L-histidine also resulted in an increase in rCBF in the hippocampus, in parallel with elevation of histamine content in the brain. The increase in rCBF in the hippocampus induced by L-histidine was antagonized by both H-1 and H-2 antagonists (diphenhydramine, pyrilamine and zolantidine). In addition, when both antagonists were injected simultaneously, an additive effect was observed in antagonism of the L-histidine-induced increase in rCBF L-histidine caused no marked changes in blood pressure even at a dose of 1,500 mg/kg, which showed an increase in rCBF in the hippocampus. These results indicate that histamine elicited tm increase in rCBF via both H-1 and H-2 receptors. (C) 1999 Prous Science. All rights reserved.

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  • Slow wave sleep-inducing effects of first generation H-1-antagonists

    K Saitou, Y Kaneko, Y Sugimoto, Z Chen, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN22 ( 10 ) 1079 - 1082   1999年10月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    The present study was performed to see if first-generation histamine H-1-antagonists are useful sedative-hypnotic drugs. Increases in electroencephalogram (EEG) power spectra of the delta band (0-4 Hz) at the frontal cortex and theta band (4-8 Hz) at the hippocampus in rats were used as an indexes of sleep. The H-1-antagonists used in this study resulted in a decrease in sleep latency and an increase in sleep duration (slow wave sleep), The rate of REM (rapid eye movement) sleep during slow wave sleep was decreased by H-1-antagonists and brotizolam. The order of potency of H-1-antagonists for the reduction in sleep latency (from greatest to least) was promethazine>chlorpheniramine>diphenhydramine and pyrilamine, and that for the increase in sleep duration was chlorpheniramine>promethazine>diphenhydramine and pyrilamine, Brotizolam was more potent than these H-1-antagonists, with 14-18-fold and 4-14-fold greater effects on sleep latency and duration, respectively. These results clearly show that H-1-antagonists are effective in mild to moderate insomnia as sedative-hypnotic drugs.

    DOI: 10.1248/bpb.22.1079

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  • Effects of histamine on MK-801-induced memory deficits in radial maze performance in rats

    Z Chen, Q Zhao, Y Sugimoto, Y Fujii, C Kamei

    BRAIN RESEARCH839 ( 1 ) 186 - 189   1999年8月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The effects of histamine on the spatial memory deficits induced by MK-801 were investigated using the eight-arm radial maze paradigm in rats. Intracerebroventricular (i.c.v.) injection of histamine or thioperamide, and intraperitoneal (i.p.) injection of histidine improved the spatial memory deficits induced by MK-801. Similar results were obtained with 2-thiazolylethylamine. In contrast, 4-methylhistamine showed no significant effect. Based on these observations, it seems likely that the protective effect of histamine on MK-801-induced spatial memory deficit is mediated by H-1-receptors. (C) 1999 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0006-8993(99)01739-4

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  • [Arg(8)]-Vasopressin-induced increase in intracellular Ca2+ concentration in cultured rat hippocampal neurons

    T Mihara, T Tarumi, Y Sugimoto, Z Chen, C Kamei

    BRAIN RESEARCH BULLETIN49 ( 5 ) 343 - 347   1999年7月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Changes in intracellular Ca2+ concentration ([Ca2+](i)) induced by [Arg(8)]-vasopressin (AVP) were studied in cultured rat hippocampal neurons by fura-2 fluorometry. AVP (10-1,000 nM) caused a dose-dependent increase in [Ca2+](i). The selective V-1 vasopressin receptor agonist [Phe(2), Ile(3), Orn(8)]-vasopressin also induced a significant increase in [Ca2+](i), whereas the selective V-2 vasopressin receptor agonist [deamino Cys(1), D-Arg(8)]-vasopressin showed no effect. The AVP-induced increase in [Ca2+](i) was inhibited by the selective V-1 vasopressin receptor antagonist d(CH2)(5)[Tyr(2)(Me), Arg(8)]-vasopressin and nonpeptide V, antagonist OPC-21268. On the other hand, no antagonistic effects were observed with the V vasopressin antagonist desglycinamide-[d(CH2)(5), D-Ile(2), Ile(4), Arg(8)]-vasopressin and nonpeptide V-2 antagonist OPC-31260, The increase in [Ca2+](i) induced by AVP was abolished after removal of extracellular Ca2+. In addition, AVP-induced [Ca2+](i) elevation was not affected by treatment with verapamil, which blocked the [Ca2+](i) increase induced by an isotonic high K+-medium (50 mM), However, omega-conotoxin GVIA completely inhibited the effect of AVP, These results suggested that the AVP-induced [Ca2+](i) increase in cultured rat hippocampal neurons is due to influx of Ca2+ through V-1 VP receptors coupled with N-type calcium channels. (C) 1999 Elsevier Science Inc.

    DOI: 10.1016/S0361-9230(99)00064-7

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  • Effects of Fujibitol, a remedy for nasal symptoms of immediate and delayed type allergic reactions

    M Kakimoto, N Takasugi, T Fuwa, H Saito, Y Sugimoto, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY21 ( 5 ) 353 - 356   1999年6月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The effects of Fujibitol, a remedy for the nasal symptoms of immediate and delayed type allergic reactions were studied. Fujibitol inhibited active systemic anaphylaxis in mice, heterologous passive cutaneous anaphylaxis (PCA) in rats, Masugi's nephritis in rats and delayed type hypersensitivity induced by picryl chloride in mice, but did not affect homologous PCA or immune complex-induced glomerulonephritis in rats. These results suggested that Fujibitol is effective for treatment of allergy-induced inflammation since Ige and type IV allergic reactions were inhibited. (C)1999 Prous Science. All rights reserved.

    DOI: 10.1358/mf.1999.21.5.541913

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  • Effects of levocabastine on lipid mediator release from guinea pig lung fragments.

    Yukio Sugimoto, Yoshinori Iba, Keisuke Ishizawa, Genzo Suzuki, Chiaki Kamei

    Acta Med. Okayama53 ( 6 ) 271 - 374   1999年

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  • Characterization of intestinal histamine contents in Brown-Norway rats. -Influence of actively sensitization-

      20 ( Suppl. 1 ) S29-S34   1999年

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  • Brown-Norway系ラットにおける消化管ヒスタミン含量の特徴−能動感作による影響−

    杉本幸雄, 亀井千晃

    セラピューティック・リサーチ20 ( Suppl. 1 ) S29-S34   1999年

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  • Studies on the sleep-inducing effect of diphenhydramine hydrochloride.

      27 ( 5 ) 777 - 781   1999年

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  • Effects of anti-parkinson drugs on neurobehavioral changes induced by bilateral 6-hydroxydopamine lesions in rats.

    Tsuyoshi Hayakawa, Yukio Sugimoto, Zhong Chen, Yoko Fujii, Chiaki Kamei

    Clin. Exp. Pharmacol. Physiol.26   421 - 425   1999年

  • 塩酸ジフェンヒドラミンによる睡眠導入作用の検討

    亀井千晃, 齊藤康一, 杉本幸雄, 陳 忠, 趙 秋蛾

    薬理と治療27 ( 5 ) 777 - 781   1999年

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  • Strain differences in histamine release from peritoneal mast cells in rats

    Y Sugimoto, H Ohishi, T Toyota, C Kamei

    GENERAL PHARMACOLOGY31 ( 4 ) 613 - 616   1998年10月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    1. Peritoneal mast cells from Brown-Norway (BN) rats were compared with those from Wistar and Sprague-Dawley (SD) rats.
    2. Peritoneal mast cells from BN rats showed the smallest values in number, cell diameter and histamine contents compared with those from Wistar and SD rats.
    3. BN rat peritoneal mast cells were more sensitive to compound 48/80 and anti-IgE than were those from Wistar and SD rats, and they showed a higher response to A23187 than did cells from Wistar rats.
    4. The histamine release from passively sensitized peritoneal mast cells was weaker in BN rats than was that from Wistar and SD rats. (C) 1998 Elsevier Science Inc.

    DOI: 10.1016/S0306-3623(98)00063-9

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  • Effects of antiallergic drugs on histamine release from rat peritoneal mast cells induced by bradykinin

    Y Sugimoto, T Tarumi, QE Zhao, Y Fujii, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY20 ( 6 ) 457 - 462   1998年7月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    Effects of antiallergic drugs on bradykinin-induced histamine release and intracellular Ca2+ release from peritoneal mast cells were studied ill mrs. Bradykinin caused a concentration-dependent histamine release as well as Ca2+ release from the intracellular Ca store of peritoneal mast cells. Antiallergic drugs used in tills study showed an inhibition of not only histamine release but also Ca2+ release. The Ca2+ release from the intracellular Ca store induced by bradykinin was more sensitive to antiallergic drugs than histamine release from mast cells. Mequitazine and terfenadine caused potent inhibitory effects oil both responses, whereas effects of ketotifen and cromolyn sodium were relatively weak. In conclusion, histamine release from mast cells and intracellular C2+ release induced by bradykinin were inhibited by antiallergic drugs similar to those induced by substance P and compound 48/80. (C) 1998 Prous Science. All rights reserved.

    DOI: 10.1358/mf.1998.20.6.485708

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  • Effects of histamine H-1 receptor antagonists on compound 48/80-induced scratching behavior in mice

    Y Sugimoto, K Umakoshi, N Nojiri, C Kamei

    EUROPEAN JOURNAL OF PHARMACOLOGY351 ( 1 ) 1 - 5   1998年6月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The effects of histamine H-1 receptor antagonists on compound 48/80-induced scratching behavior were studied in mice. Classical histamine H-1 receptor antagonists such as diphenhydramine and chlorpheniramine caused a potent depressant effect on compound 48/80-induced scratching behavior. Histamine H-1 receptor antagonists having antiallergic activity (an inhibition of mast cell degranulation), such as azelastine and oxatomide and nonsedative histamine H-1 receptor antagonists such as terfenadine, epinastine and astemizole, also showed a relatively potent effect. On the other hand, the effects of tranilast and cromolyn sodium-antiallergic drugs without histamine H-1 receptor antagonistic activity-were extremely weak. Diazepam had weak or no depressant effects on compound 48/80-induced scratching behavior. These results suggest that inhibition of compound 48/80-induced scratching behavior is mainly due to histamine H-1 receptor antagonistic activity and not to the sedative action of the drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S0014-2999(98)00288-X

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  • Characterization of ASK mice, a strain highly sensitive to anaphylactic shock

    H Ohmori, Y Okada, M Hikida, M Mori, Y Sugimoto, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN21 ( 3 ) 219 - 223   1998年3月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    A mouse strain named ASK that was originally isolated from El (epilepsy) mice has been shown to be highly sensitive to anaphylactic shock. Here, we characterized the bases of the sensitivity of ASK mice in comparison with the parental strain, El. More than 90% of ASIC mice, but not El mice that had been sensitized either actively or passively, died within 1 h following an antigen challenge. The anaphylactic death was effectively blocked by diphenhydramine. Plasma histamine levels increased by 30-50 fold in ASK after the antigen challenge, but only a 2-3-fold increase was observed in El mice. All (ElxASK) F-1 mice, either male or female, showed an ASK-like phenotype, suggesting that the impaired plasma histamine response in El mice is due to some recessive mutation(s). Consistent with the plasma histamine responses. cultured mast cells derived from EI bone marrow showed impaired potency to degranulate in response to surface IgE engagement, in contrast to ASK mast cells which undergo normal degranulation. Another characteristic feature of ASK mice is their sensitivity to histamine, since 75% of the mice were killed by the subcutaneous administration of 100-200 mg/kg histamine, while C3H and BALB/c mice were resistant to even 600 mg/kg histamine. Taken together, the major bases of the susceptibility to anaphylactic shock in ASK mice are thought to be the enhanced sensitivity to histamine and the recovered degranulation machinery in mast cells that is impaired in El mice.

    DOI: 10.1248/bpb.21.219

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  • Brown-Norway系ラットにおける消化管ヒスタミン含量の特徴

    杉本幸雄, 片山裕美子, 亀井千晃

    セラピューティック ・ リサーチ19 ( Suppl.1 ) S170-S175   1998年

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  • Role of substance P in experimental allergic conjunctivitis in guinea pigs

    M Yamaji, M Takada, R Fujiwara, H Ohishi, K Izushi, Y Sugimoto, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY19 ( 9 ) 637 - 643   1997年11月

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    記述言語:英語   出版者・発行元:PROUS SCIENCE, SA  

    The role of substance P in experimental allergic conjunctivitis induced by egg albumin was investigated with guinea pigs. Increase in vascular permeability of the conjunctiva induced by antigen was significantly inhibited after repealed application of capsaicin. Substance P contents in rite conjunctiva of guinea pig were decreased by typical instillation of antigen to rite eyes, suggesting that substance P was released from the conjunctiva due to antigen-antibody reaction. Moreover subconjunctival injection of substance P resulted in a close-related conjunctivitis, and vascular permeability iii the conjunctiva was also increased by substance P. In substance P-induced conjunctivitis, a significant edema was observed in the bulbar and palpebral conjunctiva, bur no hyperemia was noted in all instances. Histamine contents of the conjunctiva and tears were nor influenced by subconjunctival injection of substance P. However, topical application of antigen and subconjunctival injection of compound 48/80 caused a significant decrease in histamine content, and content of tear was increased by both treatments. An increase in vascular permeability induced by antigen application was significantly inhibited by intravenous injection of FK-888, which is a specific and potent NK1 receptor antagonist. From these results, it is suggested that substance P is responsible for allergic conjunctivitis to some extent, and the conjunctival hyperpermeability induced by substance P occurs through NK1 receptor on the blood vessels, rather than by the direct action on the conjunctival mast cells during allergic conjunctival reactions.

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  • Effects of apafant on PAF-induced downregulation of β-adrenoceptors in guinea pigs.

    Yukio Sugimoto, Yukinobu Nakayama, Hisako Kishida, Tsuyoshi Hayakawa, Rie Fujiwara, Chiaki Kamei

    Meth. Find. Exp. Clin. Pharmacol.19 ( 8 ) 547 - 552   1997年10月

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    記述言語:英語  

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  • Effect of apafant on bronchial hyperresponsiveness and down-regulation of beta-adrenoceptors induced by endotoxin in guinea pigs

    Y Sugimoto, T Mihara, T Hayakawa, Y Nakayama, H Kishida, C Kamei

    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH47 ( 7 ) 837 - 841   1997年7月

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    記述言語:英語   出版者・発行元:ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN  

    Intraperitoneal injection of endotoxin resulted in bronchial hyperreactivity to histamine in guinea pigs. In addition, endotoxin (lipopolysaccharide, LPS) caused a decrease in the relaxation of the lung parenchymal strips induced by the beta-adrenoceptor agonist, isoproterenol (isoprenaline), and a reduction in the number of beta-adrenergic binding sites in the lung membrane preparation in guinea pigs. Apafant (GAS 105219-56-5, WEB 2086) was effective in the prevention of endotoxin-induced changes, i.e., bronchial hyperreactivity to histamine, a decrease in the relaxation of lung parenchymal strips induced by isoproterenol and a reduction in the number of beta-adrenergic binding sites in the lung membrane preparation in guinea pigs. Ketotifen and ozagrel also prevented the bronchial hyperresponsiveness and endotoxin-induced deterioration of the beta-adrenergic system. No remarkable effect was observed with cromolyn sodium and salbutamol in the bronchial hyperreactivity to histamine induced by endotoxin in guinea pigs. Cromolyn sodium also caused no influence on the down-regulation of beta-adrenoceptors.

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  • Effects of intracerebroventricular injection of histamine on memory deficits induced by hippocampal lesions in rats

    C Kamei, Z Chen, S Nakamura, Y Sugimoto

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY19 ( 4 ) 253 - 259   1997年5月

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    記述言語:英語   出版者・発行元:J R PROUS SA  

    The influence of bilateral hippocampal lesions on active avoidance response was studied in rats, as well as the effect of intracerebroventricular (i.c.v.) injection of histamine on memory deficits caused by hippocampectomy. Retardation of learning acquisition was produced by lesioning of the the bilateral dorsal hippocampus in active avoidance response. Memory retention was also impaired by hippocampectomy. Although locomotor activity and rearing behavior measured by open-field test increased after hippocampal lesions, there was no relation between impairment of learning and increase in exploratory behavior. I.c.v. injection of histamine and i.p. injection of histidine resulted in an improvement of memory deficits (not only learning acquisition but also memory retrieval) induced by hippocampal lesions in mrs. Histamine contents of the hippocampus and hypothalamus decreased after hippocampectomy, and a decrease in histamine contents of both areas was restored by histamine (i.c.v.) and histidine (i.p.) injection. In addition, a close relationship was found between decrease in response latency of avoidance response and an increase in histamine content of the hippocampus and hypothalamus after histamine injection.

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  • Effect of histamine and its related compounds on impairment of passive avoidance response lollowing hippocampal lesions in rats.

    Zhong Chen, Yukio Sugimoto, Chiaki Kamei

    J. Brain Sci.23   225 - 240   1997年

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  • Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine

    C Kamei, Y Sugimoto, H Ohishi, Y Okumura, K Kitazumi

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY18 ( 9 ) 579 - 588   1996年11月

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    記述言語:英語   出版者・発行元:J R PROUS SA  

    Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin was investigated in chronic electrode-implanted rats. Ferubinac ethyl adn aspirin DL-lysine showed a spike or spike and wave complex in EEG without showing remarkable behavioral changes when they were injected intraventricularly, although a relatively high dose was needed. Enoxacin, on the other hand, elicited potent epileptogenic activity characterized by uninterrupted high voltage spike and wave complex at doses of 50 and 100 mu g. At the same time,rats showed hyperactivity, jumping and violent convulsion. Combined treatment with enoxacin (p.o.) and ferubinac ethyl (i.v.) caused potent epileptogenic activity characterized by uninterrupted burst of high voltage spike and wave complex. Behaviorally, animals showed forelimb clonus, head nodding and generalized convulsion. High voltage spike and wave complex was also observed after combined treatment with enoxacin (i. vent.) and ferubinac ethyl (i.v. or i. vent) in association with hyperactivity and jumping and violent convulsion. Nicardipine remarkably inhibited epileptic seizures induced by combined treatment with enoxacin (p.o) and ferubinac ethyl (i.v.). It is concluded that simultaneous treatment with enoxacin and ferubinac ethyl produced epileptogenic activity when injected intraventricularly, and nicardipine inhibited convulsions induced by combined use of enoxacin (p.o.) and ferubinac ethyl (i.v.).

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  • Effects of histamine and related compounds on the bovine iris dilator

    C Kamei, Y Sugimoto, Y Okumura

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY18 ( 4 ) 273 - 278   1996年5月

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    記述言語:英語   出版者・発行元:J R PROUS SA  

    Effects of histamine and related compounds on the bovine iris dilator were investigated. Histamine caused a concentration-related contraction of the bovine iris dilator and IC50 was 1.57 x 10(-7) M. The potency of histamine on the bovine iris dilator was almost the same as that observed in guinea pig ileum. Histamine-induced contraction of the bovine iris dilator was antagonized by the H-1 antagonists pyrilamine, diphenhydramine and chlorpheniramine, whereas pretreatment with the H-2 antagonists cimetidine and ranitidine was not effective. In addition, histamine, and the H-1 agonist 2-methylhistamine caused a contraction of bovine iris dilator; but the H-2 agonist 4-methylhistamine was not effective. An H-3 antagonist, thioperamide, also had no contractive effects on the bovine iris dilator. The bovine iris dilator contained a considerable amount of histamine, which was not released by compound 48/80, substance P or by increasing K+ concentration in the medium. In conclusion, histamine caused a potent contraction of the bovine iris dilator via H-1 receptor, and this muscle showed a high sensitivity to histamine similar to guinea pig ileum.

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  • Mechanism of bradykinin-induced histamine release from rat peritoneal mast cells

    QE Zhao, T Mihara, Y Sugimoto, C Kamei

    BIOLOGICAL & PHARMACEUTICAL BULLETIN19 ( 2 ) 237 - 240   1996年2月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Bradykinin at concentrations higher than 2 mu M caused a significant histamine release from rat peritoneal mast cells when estracellular Ca2+ was removed from the medium. Under the same experimental conditions, bradykinin increased Ca2+ release from the intracellular Ca store of the rat peritoneal mast cells, and a clear relationship was observed between the magnitude of histamine release and an increase in fluorescence intensity. Addition of Ca2+ to the medium resulted in an inhibition of the response to bradykinin in a concentration-dependent manner. Almost the same results were obtained when Mg2+, Ba2+ and La3+ were added to the medium. Neither B-1 nor B-2 antagonists caused significant antagonistic effects on histamine release induced by bradykinin. However, B-2 antagonists caused a histamine release of the same potency as bradykinin when applied alone. These results indicate that bradykinin-induced histamine release is not attributable to a bradykinin receptor.

    DOI: 10.1248/bpb.19.237

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  • 抗原抗体反応によるHistamine遊離に対するLoratadineの影響

    亀井千晃, 杉本幸雄, 山地雅子, 高田美穂

    薬理と治療24 ( 1 ) 49 - 52   1996年

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  • Role of substance P in experimental conianctivitis in guinea pigs.

      13 ( 3 ) 419 - 421   1996年

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  • モルモットの実験的アレルギー性結膜炎に対するSubstance Pの関与

    山地雅子, 高田美穂, 出石啓治, 杉本幸雄, 亀井千晃

    あたらしい眼科13 ( 3 ) 419 - 421   1996年

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  • Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature in mice

    Z Chen, Y Sugimoto, C Kamei

    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY17 ( 10 ) 669 - 675   1995年12月

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    記述言語:英語   出版者・発行元:J R PROUS SA  

    Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature were studied in mice. Histamine (0.0-1.0 mu g) and histidine (500-1,000 mg/kg) caused a dose-related hypothermia. H-1 agonist, 2-methylhistamine and 2-thiazolylethylamine also displayed a dose-dependent hypothermia. In addition, H-2 agonists, 4-methylhistamine and dimaprit elicited a decrease in body temperature. Preinjection of not only H-1-antagonists (diphenhydramine and chlorpheniramine) but also H-2 antagonists (cimetidine and ranitidine) abolished histamine-induced hypothermia. Either intracerebroventricular or intraperitoneal injection of thioperamide, a histamine H-3 antagonist, showed hypothermia. The hypothermic effect produced by intracerebroventricular injection of thioperamide was significantly blocked by (R)-a-methylhistamine, a selective H-3 agonist. In addition, the effect induced by thioperamide was inhibited by H-1 and H-2 antagonists, indicating that the H-3 receptor also participates in histamine-induced hypothermia.

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  • EFFECT OF (Z)-11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6,11-DIHYDRODIBENZ[B,E]OXEPIN-2-ACETIC ACID HYDROCHLORIDE ON EXPERIMENTAL ALLERGIC CONJUCTIVITIS AND RHINITIS IN RATS AND GUINEA-PIGS

    C KAMEI, Y SUGIMOTO, S NAKAMURA, C ZHONG

    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH45-2 ( 9 ) 1005 - 1008   1995年9月

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    記述言語:英語   出版者・発行元:ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN  

    The effect of KW-4679 ((Z)-11-[3-(dimethylamino) propylidene)-6,11-dihydrodibenz [b, e] oxepin-2-acetic acid hydrochloride, CAS 140462-76-6; proposed INN: olopatadine) on experimental conjunctivitis and rhinitis was studied in comparison with that of ketotifen (CAS 34580-14-8) using guinea pigs and rats, respectively. KW-4679 was effective in inhibiting the antigen- and histamine-induced conjunctivitis by both oral and topical administrations. These effects of KW-4679 were somewhat more potent than those of ketotifen. KW-4679 as well as ketotifen was moi e effective in inhibiting the histamine-induced conjunctivitis than that seen in antigen-induced conjunctivitis when they were given topically. KW-4679 inhibited the increased dye leakage into the nasal cavity induced not only by antigen in actively sensitized rats but also by histamine perfusion in non-sensitized mts by oral and topical administrations. Similar to ketotifen, the effect of KW-4679 on histamine-induced increase in dye leakage was almost same as that induced by antigen. The potency of KW-4679 was higher than that of ketotifen in the ina eased dye leakage induced by both antigen and histamine perfusion.

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  • Effect of mometasone furoate on experimetal allergic rhinitis in rats.

    Chiaki Kamei, Yukio Sugimoto, Hiroshi Kakinoki, Takayuki Izumo, Chikako Ichiki

    Japanese Pharmacology&therapeutics23 ( 11 ) 2979 - 2982   1995年

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  • THE ROLE OF IONS ON HISTAMINE-INDUCED DEPOLARIZATION IN ISOLATED GUINEA-PIG ADIPOCYTES

    C KAMEI, Y SUGIMOTO

    JAPANESE JOURNAL OF PHARMACOLOGY66 ( 4 ) 465 - 469   1994年12月

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    記述言語:英語   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

    Effects of ions on histamine (Hi)-induced depolarization were studied in guinea pig adipocytes. Depolarization induced by Hi in guinea pig adipocytes was decreased by removal of K+ from the medium or pretreatment with ouabain at concentrations that showed no significant effect themselves. The decrease in membrane potentials induced by Hi was also abolished potently by replacement of Na+ by choline or pretreatment with tetrodotoxin at a concentration that caused no significant action alone. Pretreatment with monensin at a concentration lower than that eliciting the action resulted in a potentiation of Hi-induced depolarization. The depolarization induced by Hi was not affected by the presence of Ca2+ in the medium or pretreatment of the cells by diltiazem.

    DOI: 10.1254/jjp.66.465

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  • X線造影剤の開発における安全性学的検討 -ラット大槽内用与による急性毒性と赤血球に及ぼす影響について-

    亀井千晃, 杉本幸雄, 竹内智子, 安部智之, 出雲貴幸, 安倉寿子

    基礎と臨床28 ( 12 ) 3795 - 3803   1994年

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  • SEQUENTIAL-ANALYSIS OF HISTAMINE-RELEASE AND INTRACELLULAR CA-2+ RELEASE FROM MURINE MAST-CELLS

    K TASAKA, Y SUGIMOTO, M MIO

    INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY91 ( 2 ) 211 - 213   1990年2月

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    記述言語:英語   掲載種別:記事・総説・解説・論説等(学術雑誌)   出版者・発行元:KARGER  

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  • INFLUENCE OF AGING ON THE HISTAMINE-RELEASE AND MEMBRANE FLUIDITY OF RAT PERITONEAL MAST-CELLS

    M MIO, H AKAHORI, Y SUGIMOTO, M AKAGI, K TASAKA

    PHARMACOLOGY38 ( 3 ) 191 - 200   1989年3月

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    記述言語:英語   出版者・発行元:KARGER  

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  • The Antihypertensive Effect of Consecutive Administration of Nisoldipine in Spontaneously Hypertensive Rats

    Kenji Tasaka, Chiaki Kamei, Tadami Hokonohara, Yukio Sugimoto

    Japanese Pharmacology & Therapeutics17 ( 4 ) 1545 - 1551   1989年

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  • THE EFFECTS OF CEPHEM ANTIBIOTICS AND RELATED-COMPOUNDS ON THE ALDEHYDE DEHYDROGENASE IN RAT-LIVER MITOCHONDRIA

    C KAMEI, Y SUGIMOTO, K TASAKA

    BIOCHEMICAL PHARMACOLOGY36 ( 12 ) 1933 - 1939   1987年6月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    DOI: 10.1016/0006-2952(87)90491-6

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  • ANTIHYPERTENSIVE EFFECTS OF NISOLDIPINE AND REFERENCE DRUGS IN CERTAIN TYPES OF HYPERTENSIVE RATS

    K TASAKA, C KAMEI, H TAGAMI, T HOKONOHARA, Y SUGIMOTO

    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH37 ( 3 ) 316 - 321   1987年3月

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    記述言語:英語   出版者・発行元:ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN  

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  • EFFECTS OF VARIOUS CEPHEM ANTIBIOTICS ON ETHANOL-METABOLISM AND THEIR STRUCTURE-ACTIVITY RELATIONS

    C KAMEI, Y SUGIMOTO, N MUROI, K TASAKA

    JOURNAL OF PHARMACY AND PHARMACOLOGY38 ( 11 ) 823 - 828   1986年11月

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    記述言語:英語   出版者・発行元:ROYAL PHARMACEUTICAL SOC GREAT BRITAIN  

    DOI: 10.1111/j.2042-7158.1986.tb04502.x

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▼全件表示

講演・口頭発表等

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    第70回日本栄養・食糧学会大会  2016年 

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    日本薬学会第136年会  2016年 

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    12th Asian Congress of Nutrition (ACN2015)  2015年 

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    日本薬学会第135年会  2015年 

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    第61回日本アレルギー学会秋季学術大会  2011年 

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    日本薬学会第131年会  2011年 

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    日本生薬学会第58回年会  2011年 

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    第60回日本アレルギー学会秋季学術大会  2010年 

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  • 新規低脂溶性RARβ選択的アゴニストの創製研究

    日本薬学会第130年会  2010年 

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    日本薬学会第130年会  2010年 

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    日本薬学会第128年会  2008年 

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  • アレルギー性鼻炎に対する5-アミノサリチル酸の効果

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    第114回日本薬理学会近畿部会  2008年 

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  • アレルギー性鼻炎モデルに対する5-アミノサリチル酸の効果

    第58回日本アレルギー学会秋季学術大会  2008年 

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  • RXRα/βデュアルアゴニストNEt-3IPの抗アレルギー作用

    第27回メディシナルケミストリーシンポジウム  2008年 

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    第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会  2008年 

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    第80回日本薬理学会年会  2007年 

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    第45回日本薬学会・日本病院薬剤師会中国四国支部学術大会  2006年 

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    第79回日本薬理学会年会  2006年 

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    第45回日本薬学会・日本病院薬剤師会中国四国支部学術大会(広島国際会議場  2006年 

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    第56回日本アレルギー学会秋季学術大会  2006年 

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    第76回日本薬理学会年会  2003年 

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    第53回日本アレルギー学会総会  2003年 

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    第53回日本アレルギー学会総会  2003年 

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    第7回日本ヒスタミン研究会  2003年 

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    日本薬学会第122年会  2002年 

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    第75回日本薬理学会年会  2002年 

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    第40回日本薬学会・日本病院薬剤師会中国四国支部学術大会  2001年 

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    第51回日本アレルギー学会総会  2001年 

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    第74回日本薬理学会年会  2001年 

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    第74回日本薬理学会年会  2001年 

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    第99回日本薬理学会近畿部会  2001年 

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    第39回日本薬学会中国四国支部大会  2000年 

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    International Sendai Histamine Symposium  2000年 

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    International Sendai Histamine Symposium  2000年 

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    第50回日本アレルギー学会総会  2000年 

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    第73回日本薬理学会年会  2000年 

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    第98回日本薬理学会近畿部会  2000年 

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    日本薬学会第120年会  2000年 

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  • ラット潰瘍性大腸炎モデルにおける肥満細胞の関与

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    第49回日本アレルギー学会総会  1999年 

     詳細を見る

  • デキストラン硫酸誘発潰瘍性大腸炎モデルにおけるマスト細胞の関与

    第49回日本アレルギー学会総会  1999年 

     詳細を見る

  • マウスのアレルギー性鼻炎モデルの作製とその応用

    第38回日本薬学会中国四国支部大会  1999年 

     詳細を見る

  • Effect of propolis extract on D-galactosamine-induced hepatic injury in rats

    XXXVIth Apimondia International Apicultural Congress  1999年 

     詳細を見る

  • Brown-Norway 系ラットを用いた潰瘍性大腸炎モデルの作製

    第19回ヒスタミンレセプター研究会  1999年 

     詳細を見る

  • ヒスタミン誘発引っ掻き行動におけるヒスタミン H1 および H2 受容体の関与について

    第49回日本アレルギー学会総会  1999年 

     詳細を見る

  • ラットの空間認知記憶における脳内ヒスタミンの関与

    第29回日本精神神経薬理学会年会  1999年 

     詳細を見る

  • ヒスタミン H1 受容体欠損マウスの皮膚反応における特徴

    第72回日本薬理学会年会  1999年 

     詳細を見る

  • ラットの8方向放射状迷路課題におけるヒスチジン欠乏食の影響

    第95回日本薬理学会近畿部会  1999年 

     詳細を見る

  • ヒスタミン H1 受容体欠損マウスを用いたアレルギー性鼻炎の解析

    日本薬学会第119年会  1999年 

     詳細を見る

  • Effect of peppermint extract on experimental allergic rhinitis in rats

    2nd International Conference on Food Factor  1999年 

     詳細を見る

  • Dextran sulfate sodium 誘発潰瘍性大腸炎モデルにおけるマスト細胞の関与

    第96回日本薬理学会近畿部会  1999年 

     詳細を見る

  • H1-antagonist により生ずるけいれん誘発作用について

    第38回日本薬学会中国四国支部大会  1999年 

     詳細を見る

▼全件表示

 

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  • 生理学2 (2020年度) 第2学期  - 水5,水6

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  • SGD入門 (2020年度) 第4学期  - 火7,火8

▼全件表示