Updated on 2022/06/30

写真a

 
MATSUOKA Yoshikazu
 
Organization
Okayama University Hospital Assistant Professor
Position
Assistant Professor
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Degree

  • 医学博士 ( 2007.12   岡山大学 )

  • M.D., Ph. D ( 2007.12   Okayama University )

Research Areas

  • Life Science / Anesthesiology

Education

  • 岡山大学大学院   医歯薬学総合研究科   麻酔蘇生学専攻

    2003.4 - 2007.12

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    Country: Japan

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  • Okayama University   医学部医学科  

    1993.4 - 1999.3

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    Country: Japan

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Papers

  • Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine. International journal

    Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu

    Biomolecules   12 ( 3 )   2022.3

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    The issue of tolerance to continuous or repeated administration of opioids should be addressed. The ability of ketamine to improve opioid tolerance has been reported in clinical studies, and its mechanism of tolerance may involve improved desensitization of μ-opioid receptors (MORs). We measured changes in MOR activity and intracellular signaling induced by repeated fentanyl and morphine administration and investigated the effects of ketamine on these changes with human embryonic kidney 293 cells expressing MOR using the CellKey™, cADDis cyclic adenosine monophosphate, and PathHunter® β-arrestin recruitment assays. Repeated administration of fentanyl or morphine suppressed the second MOR responses. Administration of ketamine before a second application of opioids within clinical concentrations improved acute desensitization and enhanced β-arrestin recruitment elicited by fentanyl but not by morphine. The effects of ketamine on fentanyl were suppressed by co-treatment with an inhibitor of G-protein-coupled receptor kinase (GRK). Ketamine may potentially reduce fentanyl tolerance but not that of morphine through modulation of GRK-mediated pathways, possibly changing the conformational changes of β-arrestin to MOR.

    DOI: 10.3390/biom12030426

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  • 肺切除術中の気管支出血 肺静脈閉塞に伴う区域性肺うっ血から持続的な肺胞出血を来した1症例

    照屋 洋武, 松岡 義和, 角森 雅樹, 西本 れい, 谷口 新, 森松 博史

    麻酔   71 ( 1 )   82 - 86   2022.1

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    Language:Japanese   Publisher:克誠堂出版(株)  

    気管支出血は、肺切除術中にしばしば見られる合併症である。本症例では、術中の胸膜縫合閉鎖に伴う肺区域静脈の圧排により生じた肺うっ血によって、持続的な肺胞出血を認めた。泡沫状出血や区域性の気管支粘膜発赤といった特徴的な気管支鏡所見から、原因や部位を特定した。術中に介入することで止血でき、良好な転帰を得た。(著者抄録)

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  • Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement. Reviewed International journal

    Rei Nishimoto, Sandra Derouiche, Kei Eto, Aykut Deveci, Makiko Kashio, Yoshitaka Kimori, Yoshikazu Matsuoka, Hiroshi Morimatsu, Junichi Nabekura, Makoto Tominaga

    Proceedings of the National Academy of Sciences of the United States of America   118 ( 17 )   2021.4

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    Microglia maintain central nervous system homeostasis by monitoring changes in their environment (resting state) and by taking protective actions to equilibrate such changes (activated state). These surveillance and protective roles both require constant movement of microglia. Interestingly, induced hypothermia can reduce microglia migration caused by ischemia, suggesting that microglia movement can be modulated by temperature. Although several ion channels and transporters are known to support microglia movement, the precise molecular mechanism that regulates temperature-dependent movement of microglia remains unclear. Some members of the transient receptor potential (TRP) channel superfamily exhibit thermosensitivity and thus are strong candidates for mediation of this phenomenon. Here, we demonstrate that mouse microglia exhibit temperature-dependent movement in vitro and in vivo that is mediated by TRPV4 channels within the physiological range of body temperature. Our findings may provide a basis for future research into the potential clinical application of temperature regulation to preserve cell function via manipulation of ion channel activity.

    DOI: 10.1073/pnas.2012894118

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  • Two cases of intraoperative hemodynamic instability during combined thoracoscopic-laparoscopic surgery for esophagogastric junction carcinoma. Reviewed International journal

    Makiko Tani, Yoshikazu Matsuoka, Mayu Sugihara, Ayaka Fujii, Tomoyuki Kanazawa, Hiroshi Morimatsu

    JA clinical reports   7 ( 1 )   16 - 16   2021.2

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    BACKGROUND: Intraoperative complications during combined thoracoscopic-laparoscopic surgery for esophagogastric junction (EGJ) carcinoma have not been reported as compared to those during surgery for esophageal carcinoma. We present two cases which had surgery-related hemodynamic instability during laparoscopic proximal gastrectomy and intra-mediastinal valvuloplastic esophagogastrostomy (vEG) with thoracoscopic mediastinal lymphadenectomy for EGJ carcinoma. CASE PRESENTATION: In case 1, the patient fell into hypotension with hypoxemia during laparoscopic vEG due to pneumothorax caused by entry of intraabdominal carbon dioxide. In case 2, ventricular arrythmia and ST elevation occurred during laparoscopic vEG. Pericardium retraction to secure surgical field during reconstruction compressed the coronary artery, which caused coronary malperfusion. These two events were induced by the surgical procedure, characterized by the following: (1) connection of the thoracic and abdominal cavities and (2) cardiac displacement during vEG. CONCLUSION: These cases indicated tension pneumothorax and coronary ischemia are possible intraoperative complications specific to combined thoracoscopic-laparoscopic surgery for EGJ carcinoma.

    DOI: 10.1186/s40981-021-00419-x

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  • 心不全症状を伴う胸腔内巨大慢性拡張性血腫に対して硬膜外麻酔下血腫減量術を先行した二期分割手術の麻酔経験 Reviewed

    五反田 倫子, 松岡 義和, 廣井 一正, 松岡 勇斗, 小林 求, 森松 博史

    日本臨床麻酔学会誌   41 ( 1 )   36 - 41   2021.1

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    Language:Japanese   Publisher:日本臨床麻酔学会  

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  • 穿通胎盤遺残の管理にThromboelastographyを使用した一例

    西本 れい, 廣井 一正, 松岡 義和, 日笠 友起子, 白川 拓, 坪井 千佳, 小坂 順子, 清水 一好, 賀来 隆治, 森松 博史

    日本集中治療医学会雑誌   27 ( Suppl. )   580 - 580   2020.9

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  • Anesthetic management of a patient with sodium-channel myotonia: a case report. Reviewed International journal

    Naohisa Matsumoto, Rei Nishimoto, Yoshikazu Matsuoka, Yoshimasa Takeda, Hiroshi Morimatsu

    JA clinical reports   5 ( 1 )   77 - 77   2019.11

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    BACKGROUND: Sodium-channel myotonia (SCM) is a nondystrophic myotonia, characterized by pure myotonia without muscle weakness or paramyotonia. The prevalence of skeletal muscle channelopathies is approximately 1 in 100,000, and the prevalence of SCM is much lower. To our knowledge, this is the first report on anesthetic management of a patient with SCM. CASE PRESENTATION: A 23-year-old woman with congenital nasal dysplasia and SCM was scheduled to undergo rhinoplasty with autologous costal cartilage. Total intravenous anesthesia without muscle relaxants was administered followed by continuous intercostal nerve block. Although transient elevation of potassium level in the blood was observed during surgery, the patient did not show exacerbation of myotonic or paralytic symptoms in the postoperative period. CONCLUSION: Total intravenous anesthesia and peripheral nerve block can be administered safely to a patient with SCM. However, careful monitoring of the symptoms and electrolytes is recommended.

    DOI: 10.1186/s40981-019-0300-8

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  • Tチューブ挿入中の術中人工呼吸管理にFogartyカテーテルを使用した一症例 Reviewed

    根ヶ山 諒, 岡原 修司, 熊代 美香, 塩路 直弘, 金澤 伴幸, 松岡 義和, 清水 一好, 岩崎 達雄, 森松 博史

    日本小児麻酔学会誌   25 ( 1 )   29 - 32   2019.11

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    症例は1歳11ヵ月の男児、声門下狭窄に対して輪状軟骨前方切開術が予定された。術中管理の問題点として、Tチューブ挿入後の陽圧換気中のTチューブ口側断端からのエアリークが挙げられたため、Tチューブ内にTチューブ径より小径の挿管チューブを経鼻的に留置し、挿管チューブをクランプすることで口側断端を塞ぐ方法を計画した。しかしスペースが小さく留置困難だったため、経鼻的にFogartyカテーテルをTチューブ内に留置し、バルーン拡張にて口側断端からのエアリークを軽減し、確実に換気することができた。Tチューブ挿入下での呼吸管理において、位置調整など慎重な管理は必要となるが、小児症例ではFogartyカテーテルを用いた換気方法は有用性が高いと考える。(著者抄録)

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  • Incorporation of one N-glycosylation-deficient subunit within a tetramer of HCN2 channel is tolerated. Reviewed International journal

    Kaku R, Matsuoka Y, Yang J

    Neuroreport   30 ( 15 )   998 - 1003   2019.9

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    Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are glycoproteins N-glycosylated at a specific asparagine residue in the S5-S6 linker region. Previous reports suggested that N-glycosylation-deficient HCN2 N380Q (NQ) channels fail to properly target to the plasma membrane and are unable to form functional ion channels. HCN channels are known to homo- and hetero-oligomerize and it is not known whether HCN2-NQ subunits can oligomerize with wild type (wt) N-glycosylated subunits to form a tetrameric assembly. In the present study, homomeric NQ-mutant resulted in no current, cRNA titration experiments controlling the amount of wt-to-NQ injected into Xenopus oocytes indicated that the observed currents were consistent with a model where presence of a single nonglycosylated subunit in a tetrameric oligomer is tolerated forming functional channels. The activation voltage-dependence described by half-activation voltage and slope factor, and the reversal potential of the wt-NQ oligomeric channels were identical to the wt only tetrameric channels. Further incorporation of the nonglycosylated subunit rendered the channels nonconductive or not incorporated into the plasma membrane.

    DOI: 10.1097/WNR.0000000000001310

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  • Possible biased analgesic of hydromorphone through the G protein-over β-arrestin-mediated pathway: cAMP, CellKey™, and receptor internalization analyses. Reviewed

    Sei Manabe, Kanako Miyano, Yuriko Fujii, Kaori Ohshima, Yuki Yoshida, Miki Nonaka, Miaki Uzu, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu

    Journal of pharmacological sciences   140 ( 2 )   171 - 177   2019.6

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    Morphine, fentanyl, and oxycodone are widely used as analgesics, and recently hydromorphone has been approved in Japan. Although all of these are selective for μ-opioid receptors (MORs) and have similar structures, their analgesic potencies and adverse effects (AEs) are diverse. Recent molecular analyses of MOR signaling revealed that the G protein-mediated signaling pathway causes analgesic effects and the β-arrestin-mediated signaling pathway is responsible for AEs. We used several cell-based analyses that selectively measure cellular responses activated by either G protein- or β-arrestin-mediated pathways. GloSensor™ cAMP, CellKey™, and receptor internalization assays were performed with four different types of cells stably expressing differentially labelled MOR. EC50 values measured by cAMP and CellKey™ assays had potencies in the order fentanyl ≤ hydromorphone < morphine ≤ oxycodone, all also exhibiting full agonist responses. However, in the internalization assay, only fentanyl elicited a full agonist response. Hydromorphone had the strongest potency next to fentanyl; however, contribution of the β-arrestin-mediated pathway was small, suggesting that its effect could be biased toward the G protein-mediated pathway. Based on these properties, hydromorphone could be chosen as an effective analgesic.

    DOI: 10.1016/j.jphs.2019.06.005

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  • Incidence Rates of Postoperative Pulmonary Embolisms in Symptomatic and Asymptomatic Patients, Detected by Diagnostic Images - A Single-Center Retrospective Study. Reviewed

    Matsuoka Y, Morimatsu H

    Circulation journal : official journal of the Japanese Circulation Society   83 ( 2 )   432 - 440   2019.1

  • Quercetin Attenuates Neuropathic Pain in Rats with Spared Nerve Injury. Reviewed

    Muto N, Matsuoka Y, Arakawa K, Kurita M, Omiya H, Taniguchi A, Kaku R, Morimatsu H

    Acta medica Okayama   72 ( 5 )   457 - 465   2018.10

  • Norepinephrine-induced downregulation of GLT-1 mRNA in rat astrocytes. Reviewed

    Kurita M, Matsuoka Y, Nakatsuka K, Ono D, Muto N, Kaku R, Morimatsu H

    Biochemical and biophysical research communications   504 ( 1 )   103 - 108   2018.9

  • Perioperative Management of a Child With Glucose Transporter Type 1 Deficiency Syndrome: A Case Report. Reviewed

    Yoshida T, Shimizu K, Suzuki S, Matsuoka Y, Morimatsu H

    A&A practice   11 ( 2 )   35 - 37   2018.7

  • 胸腺腫摘出術後の抜管時に冠動脈攣縮から心停止に至った1例 Reviewed

    吹田 晃享, 清水 一好, 金澤 伴幸, 松岡 義和, 森松 博史

    日本臨床麻酔学会誌   38 ( 2 )   142 - 147   2018.3

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    胸腺腫摘出術術後の抜管時に冠動脈攣縮から心停止に至ったと考えられる1例を経験した。症例は60歳、男性。術前評価で冠動脈器質的異常を認めなかったが、喫煙など複数の冠攣縮危険因子を有していた。腫瘍の浸潤性や術中循環動態の不安定性から、胸骨正中切開、静脈バイパス併用下胸腺腫摘出手術を行った。手術終了後にST上昇先行の心停止を発症したが、蘇生後の心機能回復は良好で、後遺症なく独歩退院した。術後の冠動脈攣縮誘発試験陽性から、心停止の原因は冠攣縮が強く疑われた。高侵襲手術などの手術因子、麻酔覚醒や薬剤投与などの術中因子が合わさり、冠攣縮に伴う心停止に至ったと考えられた。(著者抄録)

    DOI: 10.2199/jjsca.38.142

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  • Prolonged-duration pulsed radiofrequency is associated with increased neuronal damage without further antiallodynic effects in neuropathic pain model rats Reviewed

    Arakawa Kyosuke, Kaku Ryuji, Kurita Masako, Matsuoka Yoshikazu, Morimatsu Hiroshi

    JOURNAL OF PAIN RESEARCH   11   2645 - 2651   2018

  • 浸潤性胸腺腫摘出術後の抜管時に冠動脈攣縮から心停止に至った一例

    吹田 晃享, 松岡 義和, 金澤 伴幸, 清水 一好, 森松 博史

    日本臨床麻酔学会誌   36 ( 6 )   S354 - S354   2016.10

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  • レボチロキシン内服中止により気管切開後気管狭窄が増悪した慢性甲状腺炎の1例 Reviewed

    名原 功, 清水 一好, 片山 明, 川出 健嗣, 日笠 友起子, 林 真雄, 松岡 義和, 森松 博史

    ICUとCCU   40 ( 9 )   653 - 657   2016.9

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    慢性甲状腺炎(橋本病)は自己免疫性疾患であり、びまん性の甲状腺腫大を呈する。橋本病に対する治療薬中断により、気管切開部の気道狭窄が顕性化した症例を経験したので報告する。症例は57歳男性で、2年前に気管切開の既往があり、4ヵ月前にレボチロキシンの内服により気道狭窄が改善したエピソードがあった。今回は呼吸困難により受診し、頸部CTにて著明な気管狭窄を認め挿管管理となった。気管切開部の狭窄を浮腫や甲状腺腫大が助長させたと考え、利尿による水分管理に加え、レボチロキシンの内服を再開し気道管理を施行した。第6病日に気管狭窄は入室時より改善し抜管に至った。気管切開の既往がある慢性甲状腺炎を有する症例において、甲状腺ホルモン補充中断は甲状腺腫大増悪により気管狭窄を重症化させる危険性が高い。また、侵襲的気道管理を回避するために、甲状腺ホルモンの内服薬開を含めた内科的な集学的治療をまずは考慮すべきである。(著者抄録)

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  • Perioperative Management Center (PERIO) for Neurosurgical Patients Reviewed

    Takao Yasuhara, Tomohito Hishikawa, Takashi Agari, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Masahiro Kameda, Aiko Shinko, Joji Ishida, Masafumi Hiramatsu, Motomu Kobayashi, Yoshikazu Matsuoka, Toshihiro Sasaki, Yoshihiko Soga, Reiko Yamanaka, Takako Ashiwa, Akemi Arioka, Yasuko Hashimoto, Ayasa Misaki, Yuriko Ishihara, Machiko Sato, Hiroshi Morimatsu, Isao Date

    NEUROLOGIA MEDICO-CHIRURGICA   56 ( 9 )   574 - 579   2016

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:JAPAN NEUROSURGICAL SOC  

    Perioperative management is critical for positive neurosurgical outcomes. In order to maintain safe and authentic perioperative management, a perioperative management center (PERIO) was introduced to patients of our Neurosurgery Department beginning in June 2014. PERIO involves a multidisciplinary team consisting of anesthesiologists, dentists/dental hygienists/technicians, nurses, physical therapists, pharmacists, and nutritionists. After neurosurgeons decide on the course of surgery, a preoperative evaluation consisting of blood sampling, electrocardiogram, chest X-ray, and lung function test was performed. The patients then visited the PERIO clinic 7-14 days before surgery. One or two days before surgery, the patients without particular issues enter the hospital and receive a mouth cleaning one day before surgery. After surgery, postoperative support involving eating/swallowing evaluation, rehabilitation, and pain control is provided. The differences in duration from admission to surgery, cancellation of surgery, and postoperative complications between PERIO and non-PERIO groups were examined. Eighty-five patients were enrolled in the PERIO group and 131 patients in the non-PERIO group. The duration from admission to surgery was significantly decreased in the PERIO group (3.6 +/- 0.3 days), compared to that in the non-PERIO group (4.7 +/- 0.2 days). There was one cancelled surgery in the PERIO group and six in the non-PERIO group. Postoperative complications and the overall hospital stay did not differ between the two groups. The PERIO system decreased the duration from admission to surgery, and it is useful in providing high-quality medical service, although the system should be improved so as not to increase the burden on medical staff.

    DOI: 10.2176/nmc.oa.2016-0085

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  • The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats Reviewed

    Yuka Honda, Hitoshi Higuchi, Yoshikazu Matsuoka, Akiko Yabuki-Kawase, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Hiroshi Morimatsu, Takuya Miyawaki

    EUROPEAN JOURNAL OF PHARMACOLOGY   764   215 - 219   2015.10

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    Recent studies showed that the administration of dexmedetomidine relieved hyperalgesia in the presence of neuropathic pain. These findings have led to the hypothesis that the local administration of dexmedetomidine is useful for relieving acute inflammatory nociception, such as postoperative pain. Thus, we evaluated the inhibitory effect of locally injected dexmedetomidine on acute inflammatory nociception. Acute inflammatory nociception was induced by an intraplantar injection of 1% carrageenan into the hindpaws of rats, and dexmedetomidine was also injected combined with carrageenan. The paw withdrawal threshold based on von Frey filament stimulation was measured until 12 h after injection. We compared the area under the Lime-curve (AUC) between carrageenan and carrageenan with dexmedetomidine. To clarify that the action of dexmedetomidine was via alpha(2)-adrenoceptors, we evaluated the effect of yohimbine, a selective antagonist of alpha(2)-adrenoceptors, on the anti-nociception of dexmedetomidine. As the results, the intraplantar injection of carrageenan with over 10 mu M dexmedetomidine significantly increased AUC, compared to that with only carrageenan injection. This effect of dexmedetomidine was reversed by the addition of yohimbine to carrageenan and dexmedetomidine. These results demonstrated that the locally injected dexmedetomidine was effective against carrageenan-induced inflammatory nociception via alpha(2)-adrenoceptors. The findings suggest that the local injection of dexmedetomidine is useful for relieving local acute inflammatory nociception. (C) 2015 Elsevier B.V. All rights reserved,

    DOI: 10.1016/j.ejphar.2015.06.054

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  • Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model Reviewed

    Naoto Tomotsuka, Ryuji Kaku, Norihiko Obata, Yoshikazu Matsuoka, Hirotaka Kanzaki, Arata Taniguchi, Noriko Muto, Hiroki Omiya, Yoshitaro Itano, Tadasu Sato, Hiroyuki Ichikawa, Satoshi Mizobuchi, Hiroshi Morimatsu

    JOURNAL OF PAIN RESEARCH   7   415 - 423   2014

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    Metastatic bone cancer causes severe pain, but current treatments often provide insufficient pain relief. One of the reasons is that mechanisms underlying bone cancer pain are not solved completely. Our previous studies have shown that brain-derived neurotrophic factor (BDNF), known as a member of the neurotrophic family, is an important molecule in the pathological pain state in some pain models. We hypothesized that expression changes of BDNF may be one of the factors related to bone cancer pain; in this study, we investigated changes of BDNF expression in dorsal root ganglia in a rat bone cancer pain model. As we expected, BDNF mRNA (messenger ribonucleic acid) and protein were significantly increased in L3 dorsal root ganglia after intra-tibial inoculation of MRMT-1 rat breast cancer cells. Among the eleven splice-variants of BDNF mRNA, exon 1-9 variant increased predominantly. Interestingly, the up-regulation of BDNF is localized in small neurons (mostly nociceptive neurons) but not in medium or large neurons (non-nociceptive neurons). Further, expression of nerve growth factor (NGF), which is known as a specific promoter of BDNF exon 1-9 variant, was significantly increased in tibial bone marrow. Our findings suggest that BDNF is a key molecule in bone cancer pain, and NGF-BDNF cascade possibly develops bone cancer pain.

    DOI: 10.2147/JPR.S63527

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  • Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia Reviewed

    Satoshi Mizobuchi, Hirotaka Kanzaki, Hiroki Omiya, Yoshikazu Matsuoka, Norihiko Obata, Ryuji Kaku, Hirochika Nakajima, Mamoru Ouchida, Kiyoshi Morita

    JOURNAL OF PAIN RESEARCH   6   87 - 94   2013

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    It is generally known that peripheral nerve injury causes changes in expression of some growth factors in the dorsal root ganglion. Altered expression of ErbB receptors, a well-known growth factor in somatic cells, reportedly follows peripheral nerve injury in the spinal dorsal horn; however, it remains unknown whether the expression of these receptors is altered in the dorsal root ganglion after nerve injury. Therefore, this study examined the gene expression profiles of ErbB receptors in bilateral lumbar (L) 4/L5 dorsal root ganglia, using L5-selective spinal nerve ligation in model rats as a peripheral nerve injury model. The expression of ErbB2 and ErbB3 was observed in the dorsal root ganglia of the mature rat, despite ErbB1 and ErbB4 showing only subtle expression. We also demonstrated that peripheral nerve injury induced significant increases in ErbB2 and ErbB3 in the ipsilateral dorsal root ganglion as compared with uninjured nerve. Expression changes in ErbB receptors appear to play important roles in nerve injury and subsequent nerve regeneration.

    DOI: 10.2147/JPR.S40967

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  • Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model Reviewed

    Satoshi Mizobuchi, Yoshikazu Matsuoka, Norihiko Obata, Ryuji Kaku, Yoshitaro Itano, Naoto Tomotsuka, Arata Taniguchi, Hiroyuki Nishie, Hirotaka Kanzaki, Mamoru Ouchida, Kiyoshi Morita

    ACTA MEDICA OKAYAMA   66 ( 3 )   285 - 289   2012.6

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    Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.

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  • Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands Reviewed

    Maho Kinoshita, Yoshikazu Matsuoka, Takeshi Suzuki, Jennifer Mirrielees, Jay Yang

    BRAIN RESEARCH   1452   1 - 9   2012.5

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    Sigma1 receptors (Sigma1R) are intracellular chaperone proteins that bind psychotropic drugs and also clinically used drugs such as ketamine and haloperidol. Co-expression of the Sigma1R has been reported to enhance the sensitivity of several voltage-gated ion channels to Sigma1R ligands. Kv1.3 is the predominant voltage-gated potassium channel expressed in T lymphocytes with a documented role in immune activation. To gain a better understanding of Sigrna1R modulation of Kv ion channels, we investigated the effects of Sigma1R co-expression on Kv1.3 physiology and pharmacology in ion channels expressed in Xenopus oocytes. We also explored the protein domains of Kv1.3 necessary for protein:protein interaction between Kv1.3 and Sigma1R through co-immunoprecipitation studies. Slowly inactivating outward-going currents consistent with Kv1.3 expression were elicited on step depolarizations. The current characterized by E-rev, V-1/2, and slope factor remained unchanged when co-expressed with Sigma1R. Analysis of inactivation time constant revealed a faster Kv1.3 current decay when co-expressed with Sigma1R. However the sensitivity to Sigma1R ligands remained unaltered when co-expressed with the Sigma1R in contrast to the previously reported modulation of ligand sensitivity in closely related Kv1.4 and Kv1.5 voltage gated potassium channels. Co-immunoprecipitation assays of various Kv1.3 truncation constructs indicated that the transmembrane domain of the Kv1.3 protein was responsible for the protein:protein interaction with the Sigma1R. Sigma1R likely interacts with different domains of Kv ion channel family proteins resulting in distinct modulation of different channels. (C) 2012 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.brainres.2012.02.070

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  • SELECTIVE INHIBITION OF EXTRACELLULAR SIGNAL-REGULATED KINASES 1/2 BLOCKS NERVE GROWTH FACTOR TO BRAIN-DERIVED NEUROTROPHIC FACTOR SIGNALING AND SUPPRESSES THE DEVELOPMENT OF AND REVERSES ALREADY ESTABLISHED PAIN BEHAVIOR IN RATS Reviewed

    Y. Matsuoka, J. Yang

    NEUROSCIENCE   206   224 - 236   2012.3

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    Brain-derived neurotrophic factor (BDNF) plays a key role in the development of pathological pain. Although it is known that nerve growth factor (NGF) induces BDNF mRNA through extracellular signal-regulated kinases (ERK), whether ERK1/2 or ERK5, two closely related members of the ERK family, mediate this signal is still unclear because classical MEK inhibitors block both pathways. We studied the involvement of ERK-signaling in NGF induction of BDNF in PC12 cells, cultured dorsal root ganglia neurons, and in rats subjected to neuropathic pain models using ERK1/2- and ERK5-specific tools. Selective activation of ERK1/2 upregulated BDNF mRNA in PC12 cells, whereas selective ERK5 activation did not. AZD6244, a potent selective inhibitor of ERK1/2 activation, blocked NGF induction of BDNF mRNA in vitro suggesting that NGF induction of BDNF is mediated by ERK1/2. siRNA experiments indicated that both ERK1 or ERK2 can signal suggesting that both pathways must be blocked to prevent NGF-induced increase in BDNF mRNA. I.p. injection of AZD6244 prevented the development of pain in rats subjected to the chronic constriction injury and reversed already established pain in the spared nerve injury model. Immunohistochemical studies showed decreased phospho-ERK1/2-immunoreactivity in dorsal root ganglia and BDNF immunoreactivity in ipsilateral spinal dorsal horn in the drug-treated rats. Our results suggest the possible use of AZD6244, already in human clinical trials as an anticancer agent, for the treatment of pathological pain. (C) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

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  • Decoy strategy targeting the brain-derived neurotrophic factor exon I to attenuate tactile allodynia in the neuropathic pain model of rats Reviewed

    Norihiko Obata, Satoshi Mizobuchi, Yoshitaro Itano, Yoshikazu Matsuoka, Ryuji Kaku, Naoto Tomotsuka, Kiyoshi Morita, Hirotaka Kanzaki, Mamoru Ouchida, Masataka Yokoyama

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   408 ( 1 )   139 - 144   2011.4

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    The mechanism underlying neuropathic pain is still largely unclear. Recently, much attention has been focused on the role of brain-derived neurotrophic factor (BDNF) as a neuromodulator in the spinal cord. We previously reported that the expression of Bdnf exon I mRNA was remarkably up-regulated in the dorsal root ganglion (DRG) neurons with the rat L5 spinal nerve ligation (SNL) model. In the present study, we investigated whether neuropathic pain response would be reduced by the inhibition of the Bdnf exon I in the rat SNL model. We identified the promoter region of exon I and synthesized the decoy ODNs targeting the region. Reverse transcription-polymerase chain reaction analysis confirmed that the decoy ODN treatment reduced SNL-induced Bdnf exon I mRNA up-regulation in ipsilateral L4 and L5 DRGs. Furthermore, post-treatment with the decoy ODNs significantly attenuated SNL-induced tactile allodynia. This study suggested that decoy ODNs targeting the Bdnf exon I might provide a novel analgesic strategy for the treatment of neuropathic pain. (C) 2011 Elsevier Inc. All rights reserved.

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  • Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion Reviewed

    Megumi Omori, Masataka Yokoyama, Yoshikazu Matsuoka, Hiroyuki Kobayashi, Satoshi Mizobuchi, Yoshitaro Itano, Kiyoshi Morita, Hiroyuki Ichikawa

    BRAIN RESEARCH   1219   26 - 31   2008.7

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    We investigated changes in pain behavior after injection of acetic acid in the hindpaws of rats with L5 spinal nerve ligation (SNL)-induced neuropathy. We also examined immunoreactivity for acid-sensing ion channel 3 (ASIC3) in the dorsal root ganglion (DRG) of rats with L5 SNL. Two weeks after SNL, the withdrawal threshold to a mechanical stimulus was significantly lower in the SNL group than in the sham-operated group (n=9 per group, P&lt;0.01). After acetic acid injection, spontaneous pain responses in the SNL group were significantly increased compared to those in the sham-operated group (n = 5, P &lt; 0.05). L5 SNL significantly increased the proportion of total ASIC3-immunoreactive (ir) neurons in the ipsilateral L4 DRG compared to that in sham-operated rats (n = 4, P &lt; 0.01). Analysis of cell size showed that the proportion of large (&gt; 1200 mm(2)) ASIC3-ir neurons in the ipsilateral L4 DRG significantly increased after L5 SNL (P&lt;0.05). In the ipsilateral L5 DRG, the proportion of ASIC3-ir neurons was not significantly affected by treatment. However, L5 SNL significantly increased (P&lt;0.01) the proportion of small (&lt;1200 mm(2)) ASIC3-ir neurons and significantly decreased (P&lt;0.01) the proportion of large ASIC3-ir neurons compared to proportions in sham-operated animals. These findings suggest that ASIC3 is associated with hyperalgesia in response to a chemical stimulus in the L5 SNL rat model. (C) 2008 Published by Elsevier B.V.

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  • Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model Reviewed

    Hiroyuki Kobayashi, Masataka Yokoyama, Yoshikazu Matsuoka, Megurni Omori, Yoshitaro Itano, Rhuji Kaku, Kiyoshi Morita, Hiroyuki Ichikawa

    BRAIN RESEARCH   1206   13 - 19   2008.4

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    Brain-derived neurotrophic factor (BDNF) expression changes in the dorsal root ganglion (DRG) and spinal cord in some pain models. Recently, rat BDNF transcripts containing novel 5' untranslated exons were identified and characterized, and a new numbering system for rat BDNF exons was introduced. We examined the expression profiles of these novel BDNF transcripts in bilateral L4/5 DRGs in an L5-selective spinal nerve ligation (SSNL) model and bilateral L5 DRGs in a complete Freund's adjuvant (CFA) model of rats. L5SSNL increased significantly (P&lt;0.05) the expression of total BDNF mRNA and exon I, IIA, IIB, IIC, III, IV, VI, and IXA transcripts in ipsilateral L4 DRG. Although expression of total BDNF mRNA remained unchanged in ipsilateral L5 DRG in the L5SSNL model, expression of exon I transcript increased significantly (P&lt;0.05) and that of exon IV transcript decreased significantly (P&lt;0.05). The expression profiles of the variant exons in ipsilateral L4 DRG of the L5SSNL model were quite similar to those in ipsilateral DRG of the CFA model, and exon I transcript was the most common BDNF mRNA in these DRGs. Although L5SSNL increased significantly (P&lt;0.05) the expression of total BDNF mRNA and exon IIC and IXA transcripts in the contralateral L4/5 DRGs, CFA treatment did not alter the expression of total BDNF mRNA or specific transcripts in the contralateral DRGs. These findings suggest that exon I plays an important role in the increase in BDNF expression in ipsilateral DRGs regardless of condition. (C) 2008 Published by Elsevier B.V.

    DOI: 10.1016/j.brainres.2007.12.004

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  • Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF Reviewed

    Yoshikazu Matsuoka, Masataka Yokoyama, Hiroyuki Kobayashi, Megurni Omori, Yoshitaro Itano, Kiyoshi Morita, Hiroki Mori, Tohru Nakanishi

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   362 ( 3 )   682 - 688   2007.10

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    Expression of brain-derived neurotrophic factor (BDNF) mRNA is increased in the dorsal root ganglion (DRG) in response to peripheral inflammation. Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF. Recently, it was reported that the BDNF gene has eight non-coding exons that are transcribed independently into several splice variants. Expression of these splice variants in DRG neurons stimulated with NGF has not been studied. We examined changes in expression of BDNF splice variants in a rat model of peripheral inflammation and in cultured DRG neurons exposed to NGF. Total BDNF mRNA was increased by inflammation in vivo and by NGF in uitro. Among all splice variants, exon 1-9 showed the greatest increase in expression in both experiments. Our results indicate that exon 1-9 contributes to changes in total BDNF levels and may play an important role in the acute response of DRG to NGF. (c) 2007 Published by Elsevier Inc.

    DOI: 10.1017/j.bbrc.2007.08.022

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  • Altered response to formalin by L5 spinal nerve ligation in rats: A behavioral and molecular study Reviewed

    Ryuji Kaku, Masataka Yokoyama, Hiroyuki Kobayashi, Yoshikazu Matsuoka, Tetsufumi Sato, Satoshi Mizobuchi, Yoshitaro Itano, Kiyoshi Morita

    ANESTHESIA AND ANALGESIA   104 ( 4 )   936 - 943   2007.4

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    BACKGROUND: The status of neuropathic pain alters the responsiveness to formalin injection in rats. However, the mechanism by which this alteration occurs is unknown.
    METHODS: We used immunocytochemistry to examine the expression of brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP) in the spinal cord of rats with L5 spinal nerve ligation (SNL)-induced neuropathy, and investigated the expression of c-Fos in the spinal cord after injection of formalin in the hindpaw of rats with SNL.
    RESULTS: Four weeks after SNL, the withdrawal threshold was significantly lower in the SNL group than in the sham-operated (sham) group (n = 12 per group, P &lt; 0.05). In the SNL group, expression of BDNF in the L4 (P &lt; 0.05) and L5 (P &lt; 0.01) superficial dorsal horn was significantly decreased compared to that in the sham group. CGRP protein in the L5 but not in the L4, dorsal horn was significantly decreased compared to that in the sham group (P &lt; 0.01). After formalin injection, spontaneous pain responses in the SNL group were significantly decreased compared to those in the sham group (P &lt; 0.05). Immunolabeling for c-Fos was significantly decreased in the L4 and L5 dorsal horn in the SNL group (P &lt; 0.01).
    CONCLUSION: Our examination of c-Fos distribution indicates that decreased neuronal activity in the spinal cord in response to inflammatory pain may be important for altering the perception of acute pain. Decreased BDNF expression in response to SNL-induced neuropathy may be involved in this alteration.

    DOI: 10.1213/01.ane.0000258762.22607.15

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Books

  • 救急・集中治療 Vol.33/No.2 輸液管理 2021-’22 —ガイドライン,スタンダード,論点そして私見—

    鈴木武志( Role: Contributor ,  脳動脈瘤破裂患者(クリッピング術施行)の輸液管理)

    総合医学社  2021.6 

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  • LiSA 2020年別冊秋号 周術期管理 PERIO 10年を振り返って

    松岡義和、森松博史( Role: Contributor)

    2020.10 

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  • 術前術後のハイリスク薬 : 常用薬・持参薬・術前休止薬・術前術後使用薬 : はや調べノート : これだけは押さえておきたい : 薬がわかる!ケアにいかせる!

    小林, 求( Role: Contributor)

    メディカ出版  2016.2  ( ISBN:9784840457569

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    Total pages:167p   Language:Japanese

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  • まれな疾患の麻酔A to Z

    高崎, 眞弓, 河本, 昌志, 木内, 恵子, 白神, 豪太郎, 萩平, 哲( Role: Contributor)

    文光堂  2015.5  ( ISBN:9784830628276

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  • 確実に身につく心臓カテーテル検査の基本とコツ : 冠動脈造影所見+シェーマで、血管の走行と病変が読める!

    中川, 義久( Role: Contributor)

    羊土社  2014.3  ( ISBN:9784758107518

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  • 確実に身につく心臓カテーテル検査の基本とコツ : 冠動脈造影所見+シェーマで, 血管の走行と病変が読める!

    中川, 義久( Role: Contributor)

    羊土社  2009.7  ( ISBN:9784758106672

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  • 最新!麻酔のテクニック : 器材と技術の完全マスター

    佐藤, 哲文( Role: Contributor)

    総合医学社  2009.7  ( ISBN:9784883786015

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MISC

  • 重度呼吸機能障害のあるハイリスク食道癌患者に対する多職種介入による長期術前管理

    廣川 万里子, 板垣 栞, 田村 利枝, 三宅 裕高, 福田 智美, 松岡 義和, 小林 求, 森松 博史

    日本臨床麻酔学会誌   40 ( 6 )   S275 - S275   2020.10

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  • 【周術期管理】(PART5)周術期チーム医療のこれから PERIO 10年を振り返って

    松岡 義和, 森松 博史

    LiSA 別冊   27 ( 別冊'20秋号 )   287 - 289   2020.9

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    <文献概要>岡山大学病院(以下,当院)は,2008年に周術期管理センターperioperative management center(PERIO)を開設し,多職種連携による周術期管理を目指してきた。2018年には10周年を迎え,2020年時点で12年目である。本稿では,これまでのPERIOの歴史を振り返りながら,これからの周術期管理について考えてみたい。

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  • 術後の肺血栓塞栓症発生率と重症化に対する加齢の影響

    松岡 義和, 中塚 洸輔, 倉迫 直子, 青江 尚美, 森松 博史

    日本老年麻酔学会プログラム・抄録集   32回   68 - 68   2020.1

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  • 食道胃接合部癌に対する観音開き法鏡視下再建中、心臓圧排を誘因として心室頻拍とST上昇が生じた1症例

    藤井 彩加, 清水 達彦, 角森 雅樹, 谷 真規子, 松岡 義和, 森松 博史

    日本臨床麻酔学会誌   39 ( 6 )   S313 - S313   2019.10

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  • 硬膜外麻酔下血腫減量術が有効であった巨大慢性拡張性胸腔内血腫の一症例

    五反田 倫子, 小林 求, 松岡 勇斗, 廣井 一正, 松岡 義和, 森松 博史

    日本臨床麻酔学会誌   38 ( 6 )   S340 - S340   2018.10

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  • Tチューブ挿入中の術中人工呼吸管理にForgatyカテーテルを使用した一症例

    根ヶ山 諒, 岡原 修司, 松岡 義和, 塩路 直弘, 熊代 美香, 金澤 伴幸, 清水 一好, 岩崎 達雄, 森松 博史

    日本小児麻酔学会誌   24 ( Suppl. )   161 - 161   2018.10

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  • 神経麻酔の多職種連携 岡山大学病院における脳外科症例に対する周術期管理センターの取り組み

    松崎 孝, 松岡 義和, 谷西 秀紀, 賀来 隆治, 小林 求, 田村 利枝, 足羽 孝子, 安原 隆雄, 伊達 勲, 森松 博史

    日本神経麻酔集中治療学会プログラム・抄録集   22回   25 - 26   2018.6

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  • iPS細胞から2型肺胞上皮細胞への分化誘導

    林 真雄, 神崎 浩孝, 松岡 義和, 森松 博史

    日本集中治療医学会雑誌   23 ( Suppl. )   399 - 399   2016.1

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  • 脊髄腫瘍摘出術後に気脳症・頭蓋内出血を認めた一例

    合田 慶介, 小畑 ダニエル, 金澤 伴幸, 末盛 智彦, 松岡 義和, 佐々木 俊弘, 清水 一好, 森松 博史

    日本臨床麻酔学会誌   35 ( 6 )   S265 - S265   2015.10

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  • 治療薬内服中断による著明な甲状腺腫大に気管狭窄を合併した一症例

    名原 功, 清水 一好, 片山 明, 林 真雄, 松岡 義和, 森松 博史

    日本臨床麻酔学会誌   34 ( 6 )   S343 - S343   2014.10

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  • 小児全身型重症筋無力症の麻酔経験

    西田 静香, 小林 求, 日笠 友起子, 金澤 伴幸, 松岡 義和, 森松 博史

    日本臨床麻酔学会誌   34 ( 6 )   S294 - S294   2014.10

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  • 腹臥位胸腔鏡下食道切除術中に大量出血による心停止をきたしたが後遺症なく救命し得た1例

    植村 真弓, 小林 求, 川西 裕之, 岡原 修司, 松岡 義和, 森松 博史

    日本臨床麻酔学会誌   33 ( 6 )   S240 - S240   2013.10

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  • ラット骨がんモデルにおける腫瘍局所での神経成長因子(NGF)の発現

    友塚 直人, 谷口 新, 松岡 義和, 賀来 隆治, 溝渕 知司, 森田 潔

    日本ペインクリニック学会誌   20 ( 1 )   77 - 77   2013.2

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  • 脳脊髄液減少症患者における脳脊髄液中シスタチンC濃度

    小幡 典彦, 松岡 義和, 友塚 直人, 石川 慎一, 板野 義太郎, 横山 正尚

    PAIN RESEARCH   24 ( 2 )   82 - 82   2009.7

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  • 【最新!麻酔のテクニック 器材と技術の完全マスター】 術後管理・集中治療 PCA(Patient Controlled Analgesia)

    松岡 義和, 佐藤 健治

    麻酔科学レクチャー   1 ( 2 )   501 - 503   2009.7

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    Language:Japanese   Publisher:(株)総合医学社  

    <point>患者の状態、薬液、投与経路に応じて各項目を設定する。初期投与は効果を評価しながら行う。高齢者・重症患者では少量から始める。開始後も定期的に回診し、副作用対策、設定の見直しによって患者の満足度の高い鎮痛効果を目指す。(著者抄録)

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  • ラット炎症性疼痛モデルにおけるBDNFノックダウンデコイの疼痛抑制効果

    小幡 典彦, 松岡 義和, 板野 義太郎, 横山 正尚

    PAIN RESEARCH   24 ( 2 )   95 - 95   2009.7

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  • 培養DRGニューロンにおけるNGF刺激下でのASIC3およびTRPV1 mRNAの発現変化

    松岡 義和, 大森 恵, 板野 義太郎, 横山 正尚

    PAIN RESEARCH   23 ( 2 )   105 - 105   2008.7

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  • 脊髄神経結紮が酢酸刺激による疼痛行動に及ぼす変化に関する研究

    大森 恵, 小林 浩之, 松岡 義和, 板野 義太郎, 横山 正尚

    PAIN RESEARCH   23 ( 2 )   104 - 104   2008.7

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  • 炎症性疼痛においてBDNF遺伝子は後根神経節からプロモーター選択的に発現誘導される

    松岡 義和, 横山 正尚, 小林 宏行, 大森 恵, 板野 義太郎, 森田 潔, 森 宏樹, 中西 徹

    日本薬学会年会要旨集   128年会 ( 3 )   37 - 37   2008.3

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  • BIPAPで酸素化が維持できない重症劇症肺炎に対しairway pressure release ventilation(APRV)が奏功した1例

    松岡 義和, 山本 公三

    日本集中治療医学会雑誌   15 ( Suppl. )   206 - 206   2008.1

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  • 慢性疼痛モデルにおけるラット後根神経節のASIC3発現に関する研究

    大森 恵, 小林 浩之, 松岡 義和, 板野 義太郎, 横山 正尚

    PAIN RESEARCH   22 ( 2 )   87 - 87   2007.7

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  • 第5腰神経結紮(L5SNL)モデルにおけるフォルマリンに対する疼痛行動変化

    賀来 隆治, 小林 浩之, 松岡 義和, 板野 義太郎, 溝渕 知司, 横山 正尚, 森田 潔

    PAIN RESEARCH   21 ( 2 )   50 - 50   2006.7

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  • 第5腰神経結紮(L5SNL)モデルにおけるフォルマリンに対する疼痛行動変化の脊髄での機序の検討

    賀来 隆治, 小林 浩之, 松岡 義和, 板野 義太郎, 溝渕 知司, 横山 正尚, 森田 潔

    PAIN RESEARCH   20 ( 2 )   70 - 70   2005.7

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  • 炎症性疼痛モデルで後根神経節に発現するmultiple brain-derived neurotrophic factor transcriptの半定量解析

    松岡 義和, 小林 浩之, 賀来 隆治, 板野 義太郎, 溝渕 知司, 横山 正尚, 森田 潔

    PAIN RESEARCH   20 ( 2 )   71 - 71   2005.7

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  • 第5腰神経結紮(L5SNL)モデルで後根神経節に発現するmutiple brain-derived neurotrophic factor(BDNF)transcriptの半定量解析

    小林 浩之, 松岡 義和, 賀来 隆治, 溝渕 知司, 板野 義太郎, 横山 正尚, 森田 潔

    PAIN RESEARCH   20 ( 2 )   71 - 71   2005.7

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  • 治療に難渋した急性心筋炎の1症例

    竹中 央, 松岡 義和, 白石 建輔, 熊代 博文, 金岡 祐司, 石井 智子, 實金 健, 森本 直樹, 杉山 雅俊

    日本集中治療医学会雑誌   10 ( Suppl. )   191 - 191   2003.1

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  • 術後入院経過中に発症したARDS 6症例の検討

    高島 武煥, 松岡 義和, 新井 美奈子, 藤井 桂子, 安藤 英二, 平崎 盟人, 松下 幹晴, 小野 剛, 小西 英毅, 瀬戸 甲蔵

    日本集中治療医学会雑誌   9 ( 1Suppl. )   120 - 120   2002.1

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  • 当院における術後病棟患者のICU緊急入室例

    松下 幹晴, 高島 武煥, 松岡 義和, 新井 美奈子, 藤井 桂子, 安藤 英二, 小原 祐子, 平崎 盟人, 小野 剛, 松田 力哉

    日本集中治療医学会雑誌   9 ( 1Suppl. )   140 - 140   2002.1

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  • シルデナフィル服用によると思われた心室細動の1症例

    松岡 義和, 高島 武煥, 小野 剛, 松田 力哉, 瀬戸 甲蔵

    蘇生   20 ( 3 )   254 - 254   2001.9

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  • 下肢深部静脈血栓症を合併した卵巣腫瘍摘出術周術期管理の1症例

    松下 幹晴, 松岡 義和, 高島 武煥, 安藤 英二, 小原 祐子, 平崎 盟人, 小野 剛, 小西 英毅, 瀬戸 甲蔵, 松田 力哉

    麻酔   50 ( 8 )   924 - 924   2001.8

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  • 臨床経過よりToxic shock syndrome(TSS)が疑われ,エンドトキシン吸着及びCHDFが有効であった1例

    松岡 義和, 森松 博史, 藤井 洋泉, 奥 格, 長野 修, 松三 昌樹, 片山 浩, 平川 方久

    日本臨床麻酔学会誌   20 ( 8 )   S321 - S321   2000.9

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  • 切迫早産,妊娠中毒症にて加療中に肺水腫を合併し呼吸不全に陥った1例

    清水 啓子, 小坂 誠, 大森 恵, 松岡 義和, 五藤 恵次, 森田 潔, 平川 方久

    日本集中治療医学会雑誌   7 ( Suppl. )   196 - 196   2000.1

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Presentations

  • 早期治療介入した産後発症のSystemic capillary leak syndrome

    坂本里沙, 林真雄, 駿河磨矢, 佐倉孝信, 西本れい, 山之井智子, 黒田浩佐, 鈴木聡, 松岡義和, 森松博史

    第47回日本集中治療医学会学術集会  2020.3.6 

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    Event date: 2020.3.6

    Language:Japanese   Presentation type:Oral presentation (general)  

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  • 術後の肺血栓塞栓症発生率と重症化に対する加齢の影響

    松岡義和, 中塚洸輔, 倉迫直子, 青江尚美, 森松博史

    第32回日本老年麻酔学会  2020.2.9 

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    Event date: 2020.2.8 - 2020.2.9

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  • 重度呼吸機能障害のあるハイリスク食道癌患者に対する多職種介入による長期術前管理

    廣川万里子, 板垣栞, 田村利枝, 三宅裕高, 福田智美, 松岡義和, 小林求, 森松博史

    第40回日本臨床麻酔学会  2020.11.6 

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  • αアドレナリン受容体刺激によるGLT-1発現の低下が慢性痛モデルラットのmirror image pain発症に関係する

    中塚洸輔, 松岡義和, 栗田真佐子, 賀来隆治, 森松博史

    日本麻酔科学会第 67 回学術集会  2020.6.4 

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  • Comparison of two downstream signaling pathways in the μ-opioid receptors activated by several opioids

    Sei Manabe, Kanako Miyano, Yusuke Mizobuchi, Eiko Uezono, Kaori Oshima, Akane Komatsu, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Hiroshi Morimatsu, Yasuhito Uezono

    2020.3.16 

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  • 穿通胎盤遺残の管理にThromboelastographyを使用した一例

    西本れい, 廣井一正, 松岡義和, 日笠友紀子, 白川拓, 坪井千佳, 小坂順子, 清水一好, 賀来隆治, 森松博史

    第47回日本集中治療医学会学術集会  2020.3.6 

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Industrial property rights

  • 疼痛の治療剤およびその利用

    板野 義太郎, 松岡 義和, 大内田 守

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    Applicant:国立大学法人 岡山大学

    Application no:特願2010-514435  Date applied:2009.5.14

    Patent/Registration no:特許第5545211号  Date registered:2014.5.23  Date issued:2014.5.23

    J-GLOBAL

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  • 疼痛の治療剤およびその利用

    板野 義太郎, 松岡 義和, 大内田 守

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    Applicant:国立大学法人 岡山大学

    Application no:JP2009058996  Date applied:2009.5.14

    Announcement no:WO2009-145067  Date announced:2009.12.3

    Publication no:WO2009-145067  Date published:2009123

    J-GLOBAL

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Awards

  • Fukushima Award

    2022.2   Incidence Rates of Postoperative Pulmonary Embolisms in Symptomatic and Asymptomatic Patients, Detected by Diagnostic Images - A Single-Center Retrospective Study.

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  • 最優秀演題

    2020.2   日本老年麻酔学会   術後の肺血栓塞栓症発生率と重症化に対する加齢の影響

    松岡義和

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

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Research Projects

  • 術後遷延痛における脊髄グルタミン酸トランスポーターの役割に関する検討

    Grant number:21K08995  2021.04 - 2024.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    賀来 隆治, 松岡 義和

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    Grant amount:\3380000 ( Direct expense: \2600000 、 Indirect expense:\780000 )

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  • Splice-variant specific knock-down of Neuregline 1 as a treatment for chemotherapy-induced peripheral neuropathy

    Grant number:18K08816  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    松岡 義和, 賀来 隆治

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    Grant amount:\3770000 ( Direct expense: \2900000 、 Indirect expense:\870000 )

    本研究では、抗癌剤による末梢神経障害(化学療法誘発性末梢神経障害、Chemotherapy-induced peripheral neuropathy, CIPN)の病態の解明を目的とする。 Neuregulin1は神経再生・分化に重要な糖タンパクであり、先行研究により神経障害性痛発症への関与が示されている。本研究ではCIPNモデルを作成し、 Neuregulin1の変化を測定し、その中でCIPNに特異的なNeuregulin1スプライスバリアントの変化につき検討し、スプライスバリアント特異的ノックダウンによる CIPNの予防または治療の開発をめざす。
    初年度に作成した動物モデルではNerureglin1の変化が不安定であったため、薬剤を変更しモデル作成した。
    CIPNモデルとして5週齢雄性SDラットにビンクリスチン0.1または0.2mg/kgを腹腔内注射し、von Freyフィラメン トによる機械的疼痛域値(50%PWT)測定を、モデル作成前および作成後3、5、7、8、10、14日目に測定した。その結果疼痛域値の低下が認められ、CIPNが誘発されたことを確認した。モデル作成14日目にDRGを摘出し、各スプライスバリアント特異的プライマーによりmRNA発現を定量PCR法で測定した。0.2mg/kg投与 によりNeuregulin1スプライスバリアントType1-3いずれも低下する傾向にあったが、統計的に有意な変化ではなかった。

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  • Developing drug for neuropathic pain by chemically modified flavonoids targeting MEK

    Grant number:25870459  2013.04 - 2016.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Matsuoka Yoshikazu

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    Grant amount:\3900000 ( Direct expense: \3000000 、 Indirect expense:\900000 )

    The aim of this study was to investigate the effect of quercetin on the neuropathic pain in the rat model. Pre-treatment of neuropathic pain by oral administrated quercetin prevented the development of pain behavior in the rat with spared nerve injury model. On the other hand, post-treatment failed to reverse the pain behavior. Immunohistochemisty and western blotting showed significant suppression of GFAP protein, a marker of astrocyte activation, in dorsal root ganglion in the treated rats. These results showed that the effect of quercetin on the neuropathic pain was mediated by the suppression of activation of satellite glial cells in dorsal root ganglia.

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  • Basic research of pain control by DNA decoy for brain-derived neurotrophic factor

    Grant number:21592008  2009 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    YOKOYAMA Masataka, OBATA Norihiko, MATSUOKA Yoshikazu

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    We made DNA decoy for brain-derived neurotrophic factor(BDNF) exon-1 that is increased significantly in the spinal level of neuropathic pain model. We administered DNA decoy intrathecally to knock-down BDNF exon-1 in pain model rats, and confirmed that pain response was decreased by DNA decoy.

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Class subject in charge

  • Research Projects and Practicals: Anesthesiology and Resuscitology I (2021academic year) special  - その他

  • Lecture and Research Projects: Anesthesiology and Resuscitology I (2021academic year) special  - その他

  • Research Projects and Practicals: Anesthesiology and Resuscitology II (2021academic year) special  - その他

  • Lecture and Research Projects: Anesthesiology and Resuscitology II (2021academic year) special  - その他

  • Research Projects and Practicals: Anesthesiology and Resuscitology I (2020academic year) special  - その他

  • Lecture and Research Projects: Anesthesiology and Resuscitology I (2020academic year) special  - その他

  • Research Projects and Practicals: Anesthesiology and Resuscitology II (2020academic year) special  - その他

  • Lecture and Research Projects: Anesthesiology and Resuscitology II (2020academic year) special  - その他

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