Faculty Profiles - MATSUOKA Yoshikazu

写真a

MATSUOKA Yoshikazu

Organization

Scheduled update Lecturer

External link

Degree

医学博士 ( 2007.12 岡山大学 )
M.D., Ph. D ( 2007.12 Okayama University )

Research Areas

Life Science / Anesthesiology

Education

岡山大学大学院医歯薬学総合研究科麻酔蘇生学専攻

2003.4 - 2007.12

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Country： Japan

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Okayama University 医学部医学科

1993.4 - 1999.3

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Country： Japan

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Committee Memberships

日本学術振興会科学研究費委員会専門委員

2024.8

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Committee type：Academic society

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日本麻酔科学会学術集会実行委員会ワーキンググループ員

2023.5

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Committee type：Academic society

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Papers

A Pilot Study of Urine Oxytocin as an Objective Biomarker for Chronic Pain Reviewed

Daisuke Ono, Takashi Matsusaki, Yoshikazu Matsuoka, Ryuji Kaku, Hiroshi Morimatsu

Annals of Neurosciences 2025.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1177/09727531231224141

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Advancing Health Care in Regional Hub City: Introduction of Laparoscopic Sleeve Gastrectomy as Bariatric and Metabolic Surgery with Promising Results Reviewed

Hajime Kashima, Shunsuke Kagawa, Yoshihiko Kakiuchi, Satoru Kikuchi, Shinji Kuroda, Junko Kosaka, Yoshikazu Matsuoka, Manabu Takaki, Akihiro Katayama, Atsuhito Tone, Ichiro Nojima, Atsuko Nakatsuka, Jun Eguchi, Jun Wada, Toshiyoshi Fujiwara

Bariatric Surgical Practice and Patient Care 2025.8

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Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

DOI： 10.1177/2168023x251366339

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Other Link： https://www.liebertpub.com/doi/pdf/10.1177/2168023X251366339
Novel Therapeutic Algorism in Patients With Anterior Cutaneous Nerve Entrapment Syndrome Reviewed

Yoshitaka Kondo, Nobuhiko Kanaya, Ami Kobayashi, Kyosuke Arakawa, Yoshikazu Matsuoka, Yudai Mimata, Yoshihiko Kakiuchi, Kunitoshi Shigeyasu, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

Neurology and Clinical Neuroscience 2025.7

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<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Anterior cutaneous nerve entrapment syndrome (ACNES) is often overlooked as a cause of chronic abdominal pain. Trigger point injections (TPIs) serve as both a diagnostic and therapeutic tool. Although neurectomy is frequently chosen for patients with severe ACNES, its surgical outcomes remain unclear.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>This study aims to evaluate both the short‐ and long‐term outcomes for neurectomy and propose a novel therapeutic algorithm.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>A cohort of postoperative patients presenting with ACNES between 2016 and 2023 was retrospectively evaluated. Patients received a single diagnostic TPI. When the pain subsided, an anterior neurectomy was performed using either an anterior or laparoscopic approach. Pain scores were assessed using the numeric rating scale (NRS).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 37 patients (60% females, mean age 33.8 ± 3.4 years), 29 patients (78.4%) experienced pain recurrence following initial neurectomy. Of these, 22 patients underwent repeat neurectomies, resulting in complete remission in 15 patients and no benefit in 7 patients. Long‐term outcomes showed that 62.2% achieved clinical remission (NRS = 0), whereas 8.1% reported reduced but persistent pain (NRS 1–2). Preoperative TPI effectiveness was a strong predictor of surgical success, with patients achieving post‐TPI NRS (0–1) significantly more likely to attain remission (<jats:italic>p</jats:italic> = 0.0074). Older age was also associated with higher remission rates (<jats:italic>p</jats:italic> = 0.0476).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>TPI is critical for predicting neurectomy success. These findings support the integration of preoperative TPI evaluation and tailored surgical strategies to optimize outcomes for patients with ACNES.</jats:p></jats:sec>

DOI： 10.1111/ncn3.70008

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The Geriatric Nutritional Risk Index: A Key Indicator of Perioperative Outcome in Oldest-old Patients With Colorectal Cancer. Reviewed International journal

Fuminori Teraishi, Masashi Utsumi, Yusuke Yoshida, Ryohei Shoji, Nobuhiko Kanaya, Yuki Matsumi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Shiori Itagaki, Rie Tamura, Yoshikazu Matsuoka, Toshiyoshi Fujiwara, Masaru Inagaki

In vivo (Athens, Greece) 39 ( 5 ) 2810 - 2817 2025

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BACKGROUND/AIM: Colorectal cancer (CRC) presents a significant challenge in oldest-old patients (≥85 years), where surgical intervention carries substantial perioperative risks. Nutritional status is a crucial determinant of outcomes, and the Geriatric Nutritional Risk Index (GNRI) has shown promise. This prospective study aimed to validate the GNRI as a key indicator of perioperative outcomes in oldest-old patients undergoing CRC surgery, and to establish its utility in preoperative risk stratification. PATIENTS AND METHODS: This prospective study enrolled patients aged ≥85 years undergoing elective surgery for CRC. Preoperative GNRI was calculated using the formula: GNRI=14.89×serum albumin (g/dl)+41.7×[actual body weight/ideal body weight (corresponding to body mass index 22)]. Patients were stratified into two groups: GNRI >98 and GNRI ≤98. Baseline demographics, clinical characteristics, geriatric assessments (including Geriatric-8 and EuroQol 5 dimension), and postoperative complication rates were analyzed. RESULTS: Twenty-four patients (median age 88 years, interquartile range=86-91) were included: 11 in the GNRI >98 group and 13 in the GNRI ≤98 group. The patients with GNRI >98 demonstrated significantly better G8 scores (median 12 vs. 11, p<0.01) and EQ-5D index values (median 88 vs. 75.0, p<0.01). The postoperative complication rate was significantly higher in the GNRI ≤98 group (p=0.02). CONCLUSION: Preoperative GNRI effectively identifies oldest-old patients with CRC at increased risk for postoperative complications. A GNRI ≤98 correlates with poorer nutritional status and impaired geriatric functional parameters. These findings highlight GNRI's utility as a simple, valuable tool for preoperative risk stratification, potentially guiding interventions to optimize outcomes in this vulnerable population.

DOI： 10.21873/invivo.14080

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Subjective global assessment for nutritional screening and its impact on surgical outcomes: A prospective study in older patients with colorectal cancer. Reviewed International journal

Fuminori Teraishi, Yusuke Yoshida, Ryohei Shoji, Nobuhiko Kanaya, Yuki Matsumi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Shunsuke Kagawa, Rie Tamura, Yoshikazu Matsuoka, Hiroshi Morimatsu, Toshiharu Mitsuhashi, Toshiyoshi Fujiwara

Langenbeck's archives of surgery 409 ( 1 ) 356 - 356 2024.11

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PURPOSE: Our perioperative management center provides preoperative intervention and functional and nutritional assessments for colorectal cancer patients aged over 75 years. This study evaluated the associations of preoperative nutritional status with postoperative outcomes and prognosis in colorectal cancer patients aged 75 years or older. METHODS: This was a prospective, observational study of 71 colorectal cancer patients aged 75 years or older who underwent surgery between July 2020 and September 2022. The Subjective Global Assessment (SGA) was evaluated as a nutritional index. The patients were classified into three groups: SGA-A (well nourished), B (moderately malnourished), and C (severely malnourished), and the correlations with postoperative outcomes and prognosis were examined. RESULTS: The median age of the 71 patients (34 males, 37 females) was 78 (75-92) years, and their median body mass index (BMI) was 22.3 (13.4-31.9) kg/m2. Forty-eight patients had colon cancer, and 23 had rectal cancer. On the SGA, 28 patients were SGA-A, 25 SGA-B, and 18 SGA-C. The SGA-B/C group had significantly higher BMI (p < 0.01) and more ICU admissions (p = 0.02). The G8 score was significantly lower (p = 0.03) in the SGA-B/C group, suggesting coexisting functional decline. In terms of postoperative outcomes, the SGA-B/C group had a significantly longer postoperative hospital stay (p = 0.04). The 3-year OS rates for all stages were 100% in the SGA-A group and 49.7% in the SGA-B/C group (p = 0.03), while the 3-year OS rates for patients excluding Stage IV were 100% in the SGA-A group and 68.5% in the SGA-B/C group, not significantly different (p = 0.14). The 3-year RFS rate was 95.5% in the SGA-A group and 65.3% in the SGA-B/C group (p = 0.15). CONCLUSION: The SGA is a promising nutritional index associated with short-term outcomes in older patients undergoing colorectal cancer surgery. The SGA can be assessed in a few minutes during an outpatient visit, making it useful for routine clinical use.

DOI： 10.1007/s00423-024-03548-w

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Comprehensive geriatric assessment as an indicator of postoperative recovery in older patients with colorectal cancer. Reviewed International journal

Fuminori Teraishi, Ryohei Shoji, Yoshitaka Kondo, Shunsuke Kagawa, Rie Tamura, Yoshikazu Matsuoka, Hiroshi Morimatsu, Toshiharu Mitsuhashi, Toshiyoshi Fujiwara

Journal of geriatric oncology 101837 - 101837 2024.7

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DOI： 10.1016/j.jgo.2024.101837

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Clinical Impact of Prehabilitation on Elective Laparoscopic Surgery in Frail Octogenarians With Colorectal Cancer. Reviewed International journal

Fuminori Teraishi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Shunsuke Kagawa, Rie Tamura, Yoshikazu Matsuoka, Hiroshi Morimatsu, Toshiyoshi Fujiwara

Anticancer research 43 ( 12 ) 5597 - 5604 2023.12

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BACKGROUND/AIM: The aim of the present study was to clarify the clinical impact of prehabilitation by the perioperative management center (PERIO) at our hospital in severely frail octogenarians with colorectal cancer. PATIENTS AND METHODS: We compared the clinicopathological characteristics of octogenarians who underwent surgery for colorectal cancer before the establishment of PERIO intervention (Control group) with those who received prehabilitation (PERIO group). All patients were classified as American Society of Anesthesiologists (ASA) class 3 or higher. The primary outcome was the incidence of postoperative complications. RESULTS: There were 21 patients in the Control group and 19 patients in the PERIO group. Operative time was significantly longer in the PERIO group (Control group, 200 min vs. PERIO group, 230 min; p=0.03) and blood loss was significantly higher in the PERIO group (Control group, 5 ml vs. PERIO group, 30 ml; p=0.02). Postoperative complications occurred in 10 patients (47.6%) in the Control group and 3 patients (15.8%) in the PERIO group and were significantly lower in the PERIO group (p=0.03). Postoperative hospital stay was 13 days (range=7-31 days) in the Control group and 11 days (range=8-70 days) in the PERIO group (p=0.39). The rate of discharge directly to home was 81% in the Control group and 93.3% in the PERIO group (p=0.29). CONCLUSION: In frail octogenarians with colorectal cancer of ASA class 3 or higher, the incidence of postoperative complications was significantly lower after PERIO intervention.

DOI： 10.21873/anticanres.16762

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An Assessment of the Practice of Neuromuscular Blockade and the Association Between Its Prophylactic Use and Outcomes Among Postoperative Pediatric Cardiac Patients. Reviewed International journal

Satoshi Kimura, Kazuyoshi Shimizu, Yoshikazu Matsuoka, Tatsuo Iwasaki, Tomoyuki Kanazawa, Hiroshi Morimatsu

Journal of cardiothoracic and vascular anesthesia 37 ( 6 ) 980 - 987 2023.6

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OBJECTIVES: The authors investigated the management of neuromuscular blocking agents (NMBAs) for pediatric patients after cardiac surgery, and compared the outcomes of patients who received prophylactic NMBA (pNMBA) infusions and patients without pNMBA infusions. DESIGN: A retrospective cohort study. SETTING: At a tertiary teaching hospital. PARTICIPANTS: Patients younger than 18, with congenital heart disease, who underwent cardiac surgery. INTERVENTIONS: Commencement of NMBA infusion in the first 2 hours after surgery MEASUREMENTS AND MAIN RESULTS: The primary endpoint was a composite of one or more of the following major adverse events (MAEs) that occurred within 7 days after surgery: death from any cause, a circulatory collapse that needed cardiopulmonary resuscitation, and requirement for extracorporeal membrane oxygenation. The secondary endpoints included the total duration of mechanical ventilation for the first 30 days after surgery. A total of 566 patients were included in this study. The MAEs occurred in 13 patients (2.3%). An NMBA was commenced within 2 hours after surgery in 207 patients (36.6%). There were significant differences in the incidence of postoperative MAEs between the pNMBA group and the non-pNMBA group (5.3% v 0.6%; p < 0.001). In multivariate regression models, pNMBA infusion was not significantly associated with the incidence of MAEs (odds ratio: 1.79, 95% CI: 0.23-13.93, p = 0.58), but was significantly associated with prolonged mechanical ventilation by 3.85 days (p < 0.001). CONCLUSIONS: Postoperative prophylactic neuromuscular blockade after cardiac surgery can be associated with prolonged mechanical ventilation, but has no association with MAEs among pediatric patients with congenital heart disease.

DOI： 10.1053/j.jvca.2023.02.030

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The Japanese Epidemiologic Study for Perioperative Anaphylaxis, a prospective nationwide study: allergen exposure, epidemiology, and diagnosis of anaphylaxis during general anaesthesia. Reviewed International journal

Tomonori Takazawa, Tatsuo Horiuchi, Kazuhiro Nagumo, Yuki Sugiyama, Tsubasa Akune, Yasuhiro Amano, Masataka Fukuda, Takashi Haraguchi, Chika Ishibashi, Eiki Kanemaru, Takao Kato, Keiichi Katoh, Takashi Kawano, Tsukasa Kochiyama, Michioki Kuri, Akihide Kurita, Yoshikazu Matsuoka, Takahiro Muramatsu, Masaki Orihara, Yutaka Saito, Nobukazu Sato, Toshie Shiraishi, Kaoru Suzuki, Miyuki Takahashi, Toshifumi Takahashi, Kumiko Tanabe, Akihiro Tomioka, Yukinari Tomita, Tatsuya Tsuji, Iwao Watanabe, Takashige Yamada, Nagahide Yoshida, Masao Yamaguchi, Shigeru Saito

British journal of anaesthesia 131 ( 1 ) 159 - 169 2023.3

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BACKGROUND: Diagnosis of perioperative anaphylaxis is often challenging. This study describes the utility of a newly developed tool for identifying patients with a high possibility of anaphylaxis, and aimed to investigate the frequency of anaphylaxis with each drug during the perioperative period in Japan. METHODS: This study included patients with anaphylaxis of Grade 2 or higher severity during general anaesthesia at 42 facilities across Japan in 2019 and 2020. We developed and adopted a unique objective evaluation tool yielding a composite score for diagnosing anaphylaxis, which includes the results of skin tests and basophil activation tests, and clinical scores for perioperative anaphylaxis. The number of cases using each drug and the total number of anaphylaxis cases were investigated to calculate the frequency of anaphylaxis. RESULTS: General anaesthesia was performed in 218 936 cases, which included 55 patients with suspected perioperative anaphylaxis. The developed composite score diagnosed 43 of them with a high probability of anaphylaxis. The causative agent was identified in 32 cases. Plasma histamine levels showed high diagnostic accuracy for anaphylaxis. The top causative agents were rocuronium (10 cases in 210 852 patients, 0.005%), sugammadex (7 cases in 150 629 patients, 0.005%), and cefazolin (7 cases in 106 005 patients, 0.007%). CONCLUSIONS: We developed a composite tool to diagnose anaphylaxis, and found that the combination of tryptase levels, skin testing, and basophil activation testing results and clinical score improved the certainty of anaphylaxis diagnosis. The incidence of perioperative anaphylaxis in our study was 1 in about 5000 general anaesthesia cases. CLINICAL TRIAL REGISTRATION: UMIN000035350.

DOI： 10.1016/j.bja.2023.02.018

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Decreased expression of hyaluronan synthase and loss of hyaluronan-rich cells in the anterior tibial fascia of the rat model of chemotherapy-induced peripheral neuropathy. Reviewed International journal

Ruilin Wang, Yoshikazu Matsuoka, Nobutaka Sue, Kosuke Nakatsuka, Chika Tsuboi, Hiroshi Morimatsu

Pain reports 8 ( 4 ) e1088 2023

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INTRODUCTION: Previous studies on chemotherapy-induced peripheral neuropathy (CIPN) have focused on neuronal damage. Although some studies have revealed that the fascia is an important sensory organ, currently, we do not know about chemotherapy drug-induced fascial dysfunction. OBJECTIVES: This study aimed to explore the fascia as a nonneural cause of mechanical hypersensitivity in CIPN by investigating the expression of hyaluronic acid synthase (HAS) and histology of the fascia in an animal model of CIPN. METHODS: Rats were intraperitoneally administered with vincristine (VCR). Mechanical hypersensitivities of the hind paw and the anterior tibial muscle were assessed. The expression of HAS mRNA in the fascia of the anterior tibial muscles was quantitated using reverse transcription polymerase chain reaction. Immunohistochemistry was also performed for HAS2, hyaluronic acid-binding protein, and S100A4 in the fascia. RESULTS: Vincristine administration significantly decreased mechanical withdrawal thresholds in the hind paw and the anterior tibial muscle after day 3. Quantitative polymerase chain reaction showed significant downregulation of HAS mRNAs in the fascia of VCR-treated rats. Immunohistochemical analysis showed that the number of cells with strong HAS2 immunoreactivity, classified as fasciacytes by morphology and colocalized marker S100A4, decreased significantly in the VCR group. CONCLUSION: Hyaluronic acid plays a critical role in somatic pain sensation. Damaged fascia could be a possible cause of musculoskeletal pain in patients with CIPN. This study suggests that fascia is a nonneural cause and novel therapeutic target for chemotherapy-induced "peripheral neuropathy."

DOI： 10.1097/PR9.0000000000001088

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【周術期における免疫学:基礎と臨床】周術期管理における免疫関連薬剤 Invited

吉田翼, 松岡義和, 森松博史

麻酔 71 ( 9 ) 976 - 979 2022.9

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Language：Japanese Publishing type：Research paper (scientific journal) Publisher：克誠堂出版(株)

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Intrathecal Administration of the α1 Adrenergic Antagonist Phentolamine Upregulates Spinal GLT-1 and Improves Mirror Image Pain in SNI Model Rats. Reviewed

Kosuke Nakatsuka, Yoshikazu Matsuoka, Masako Kurita, Ruilin Wang, Chika Tsuboi, Nobutaka Sue, Ryuji Kaku, Hiroshi Morimatsu

Acta medica Okayama 76 ( 3 ) 255 - 263 2022.6

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Mirror image pain (MIP) is a type of extraterritorial pain that results in contralateral pain or allodynia. Glutamate transporter-1 (GLT-1) is expressed in astrocytes and plays a role in maintaining low glutamate levels in the synaptic cleft. Previous studies have shown that GLT-1 dysfunction induces neuropathic pain. Our previous study revealed bilateral GLT-1 downregulation in the spinal cord of a spared nerve injury (SNI) rat. We hypothesized that spinal GLT-1 is involved in the mechanism of MIP. We also previously demonstrated noradrenergic GLT-1 regulation. Therefore, this study aimed to investigate the effect of an α1 adrenergic antagonist on the development of MIP. Rats were subjected to SNI. Changes in pain behavior and GLT-1 protein levels in the SNI rat spinal cords were then examined by intrathecal administration of the α1 adrenergic antagonist phentolamine, followed by von Frey test and western blotting. SNI resulted in the development of MIP and bilateral downregulation of GLT-1 protein in the rat spinal cord. Intrathecal phentolamine increased contralateral GLT-1 protein levels and partially ameliorated the 50% paw withdrawal threshold in the contralateral hind paw. Spinal GLT-1 upregulation by intrathecal phentolamine ameliorates MIP. GLT-1 plays a role in the development of MIPs.

DOI： 10.18926/AMO/63719

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Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine. Reviewed International journal

Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu

Biomolecules 12 ( 3 ) 2022.3

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The issue of tolerance to continuous or repeated administration of opioids should be addressed. The ability of ketamine to improve opioid tolerance has been reported in clinical studies, and its mechanism of tolerance may involve improved desensitization of μ-opioid receptors (MORs). We measured changes in MOR activity and intracellular signaling induced by repeated fentanyl and morphine administration and investigated the effects of ketamine on these changes with human embryonic kidney 293 cells expressing MOR using the CellKey™, cADDis cyclic adenosine monophosphate, and PathHunter® β-arrestin recruitment assays. Repeated administration of fentanyl or morphine suppressed the second MOR responses. Administration of ketamine before a second application of opioids within clinical concentrations improved acute desensitization and enhanced β-arrestin recruitment elicited by fentanyl but not by morphine. The effects of ketamine on fentanyl were suppressed by co-treatment with an inhibitor of G-protein-coupled receptor kinase (GRK). Ketamine may potentially reduce fentanyl tolerance but not that of morphine through modulation of GRK-mediated pathways, possibly changing the conformational changes of β-arrestin to MOR.

DOI： 10.3390/biom12030426

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A Rare Cause of Endobronchial Hemorrhage; Segmental Pulmonary Congestion due to Interruption of Venous Outflow in Thoracic Surgery Reviewed

71 ( 1 ) 82 - 86 2022.1

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Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)

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Thermosensitive TRPV4 channels mediate temperature-dependent microglia movement. Reviewed International journal

Rei Nishimoto, Sandra Derouiche, Kei Eto, Aykut Deveci, Makiko Kashio, Yoshitaka Kimori, Yoshikazu Matsuoka, Hiroshi Morimatsu, Junichi Nabekura, Makoto Tominaga

Proceedings of the National Academy of Sciences of the United States of America 118 ( 17 ) 2021.4

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Microglia maintain central nervous system homeostasis by monitoring changes in their environment (resting state) and by taking protective actions to equilibrate such changes (activated state). These surveillance and protective roles both require constant movement of microglia. Interestingly, induced hypothermia can reduce microglia migration caused by ischemia, suggesting that microglia movement can be modulated by temperature. Although several ion channels and transporters are known to support microglia movement, the precise molecular mechanism that regulates temperature-dependent movement of microglia remains unclear. Some members of the transient receptor potential (TRP) channel superfamily exhibit thermosensitivity and thus are strong candidates for mediation of this phenomenon. Here, we demonstrate that mouse microglia exhibit temperature-dependent movement in vitro and in vivo that is mediated by TRPV4 channels within the physiological range of body temperature. Our findings may provide a basis for future research into the potential clinical application of temperature regulation to preserve cell function via manipulation of ion channel activity.

DOI： 10.1073/pnas.2012894118

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Two cases of intraoperative hemodynamic instability during combined thoracoscopic-laparoscopic surgery for esophagogastric junction carcinoma. Reviewed International journal

Makiko Tani, Yoshikazu Matsuoka, Mayu Sugihara, Ayaka Fujii, Tomoyuki Kanazawa, Hiroshi Morimatsu

JA clinical reports 7 ( 1 ) 16 - 16 2021.2

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BACKGROUND: Intraoperative complications during combined thoracoscopic-laparoscopic surgery for esophagogastric junction (EGJ) carcinoma have not been reported as compared to those during surgery for esophageal carcinoma. We present two cases which had surgery-related hemodynamic instability during laparoscopic proximal gastrectomy and intra-mediastinal valvuloplastic esophagogastrostomy (vEG) with thoracoscopic mediastinal lymphadenectomy for EGJ carcinoma. CASE PRESENTATION: In case 1, the patient fell into hypotension with hypoxemia during laparoscopic vEG due to pneumothorax caused by entry of intraabdominal carbon dioxide. In case 2, ventricular arrythmia and ST elevation occurred during laparoscopic vEG. Pericardium retraction to secure surgical field during reconstruction compressed the coronary artery, which caused coronary malperfusion. These two events were induced by the surgical procedure, characterized by the following: (1) connection of the thoracic and abdominal cavities and (2) cardiac displacement during vEG. CONCLUSION: These cases indicated tension pneumothorax and coronary ischemia are possible intraoperative complications specific to combined thoracoscopic-laparoscopic surgery for EGJ carcinoma.

DOI： 10.1186/s40981-021-00419-x

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心不全症状を伴う胸腔内巨大慢性拡張性血腫に対して硬膜外麻酔下血腫減量術を先行した二期分割手術の麻酔経験 Reviewed

五反田倫子, 松岡義和, 廣井一正, 松岡勇斗, 小林求, 森松博史

日本臨床麻酔学会誌 41 ( 1 ) 36 - 41 2021.1

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Authorship：Corresponding author Language：Japanese Publisher：日本臨床麻酔学会

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Anesthetic management of a patient with sodium-channel myotonia: a case report. Reviewed International journal

Naohisa Matsumoto, Rei Nishimoto, Yoshikazu Matsuoka, Yoshimasa Takeda, Hiroshi Morimatsu

JA clinical reports 5 ( 1 ) 77 - 77 2019.11

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BACKGROUND: Sodium-channel myotonia (SCM) is a nondystrophic myotonia, characterized by pure myotonia without muscle weakness or paramyotonia. The prevalence of skeletal muscle channelopathies is approximately 1 in 100,000, and the prevalence of SCM is much lower. To our knowledge, this is the first report on anesthetic management of a patient with SCM. CASE PRESENTATION: A 23-year-old woman with congenital nasal dysplasia and SCM was scheduled to undergo rhinoplasty with autologous costal cartilage. Total intravenous anesthesia without muscle relaxants was administered followed by continuous intercostal nerve block. Although transient elevation of potassium level in the blood was observed during surgery, the patient did not show exacerbation of myotonic or paralytic symptoms in the postoperative period. CONCLUSION: Total intravenous anesthesia and peripheral nerve block can be administered safely to a patient with SCM. However, careful monitoring of the symptoms and electrolytes is recommended.

DOI： 10.1186/s40981-019-0300-8

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Tチューブ挿入中の術中人工呼吸管理にFogartyカテーテルを使用した一症例 Reviewed

根ヶ山諒, 岡原修司, 熊代美香, 塩路直弘, 金澤伴幸, 松岡義和, 清水一好, 岩崎達雄, 森松博史

日本小児麻酔学会誌 25 ( 1 ) 29 - 32 2019.11

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Language：Japanese Publisher：日本小児麻酔学会

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Incorporation of one N-glycosylation-deficient subunit within a tetramer of HCN2 channel is tolerated. Reviewed International journal

Kaku R, Matsuoka Y, Yang J

Neuroreport 30 ( 15 ) 998 - 1003 2019.9

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Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are glycoproteins N-glycosylated at a specific asparagine residue in the S5-S6 linker region. Previous reports suggested that N-glycosylation-deficient HCN2 N380Q (NQ) channels fail to properly target to the plasma membrane and are unable to form functional ion channels. HCN channels are known to homo- and hetero-oligomerize and it is not known whether HCN2-NQ subunits can oligomerize with wild type (wt) N-glycosylated subunits to form a tetrameric assembly. In the present study, homomeric NQ-mutant resulted in no current, cRNA titration experiments controlling the amount of wt-to-NQ injected into Xenopus oocytes indicated that the observed currents were consistent with a model where presence of a single nonglycosylated subunit in a tetrameric oligomer is tolerated forming functional channels. The activation voltage-dependence described by half-activation voltage and slope factor, and the reversal potential of the wt-NQ oligomeric channels were identical to the wt only tetrameric channels. Further incorporation of the nonglycosylated subunit rendered the channels nonconductive or not incorporated into the plasma membrane.

DOI： 10.1097/WNR.0000000000001310

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Possible biased analgesic of hydromorphone through the G protein-over β-arrestin-mediated pathway: cAMP, CellKey™, and receptor internalization analyses. Reviewed

Sei Manabe, Kanako Miyano, Yuriko Fujii, Kaori Ohshima, Yuki Yoshida, Miki Nonaka, Miaki Uzu, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu

Journal of pharmacological sciences 140 ( 2 ) 171 - 177 2019.6

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Morphine, fentanyl, and oxycodone are widely used as analgesics, and recently hydromorphone has been approved in Japan. Although all of these are selective for μ-opioid receptors (MORs) and have similar structures, their analgesic potencies and adverse effects (AEs) are diverse. Recent molecular analyses of MOR signaling revealed that the G protein-mediated signaling pathway causes analgesic effects and the β-arrestin-mediated signaling pathway is responsible for AEs. We used several cell-based analyses that selectively measure cellular responses activated by either G protein- or β-arrestin-mediated pathways. GloSensor™ cAMP, CellKey™, and receptor internalization assays were performed with four different types of cells stably expressing differentially labelled MOR. EC50 values measured by cAMP and CellKey™ assays had potencies in the order fentanyl ≤ hydromorphone < morphine ≤ oxycodone, all also exhibiting full agonist responses. However, in the internalization assay, only fentanyl elicited a full agonist response. Hydromorphone had the strongest potency next to fentanyl; however, contribution of the β-arrestin-mediated pathway was small, suggesting that its effect could be biased toward the G protein-mediated pathway. Based on these properties, hydromorphone could be chosen as an effective analgesic.

DOI： 10.1016/j.jphs.2019.06.005

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Incidence Rates of Postoperative Pulmonary Embolisms in Symptomatic and Asymptomatic Patients, Detected by Diagnostic Images - A Single-Center Retrospective Study Reviewed

Matsuoka, Y., Morimatsu, H.

Circulation journal : official journal of the Japanese Circulation Society 83 ( 2 ) 432 - 440 2019.1

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DOI： 10.1253/circj.CJ-18-0729

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Quercetin Attenuates Neuropathic Pain in Rats with Spared Nerve Injury. Reviewed

Muto N, Matsuoka Y, Arakawa K, Kurita M, Omiya H, Taniguchi A, Kaku R, Morimatsu H

Acta medica Okayama 72 ( 5 ) 457 - 465 2018.10

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Quercetin is a flavonoid widely found in plants and marketed to the public as a supplement. Several studies have reported its effect on glial cells. This study aimed to examine the effect of quercetin on the development of neuropathic pain and the underlying mechanism in a spared nerve injury (SNI) rat model. Male Sprague-Dawley rats randomly assigned to the control or the quercetin group were subjected to SNI of the sciatic nerve. We measured pain behaviors on the hind paw and glial fibrillary acidic protein (GFAP) in the dorsal root ganglion (DRG) and spinal cord. Oral administration of 1% quercetin, begun before surgery, attenuated mechanical allodynia compared to the control group at days 7 and 10 after SNI. On the other hand, established pain was not attenuated in a post-dose group in which quercetin was begun 7 days after SNI. Quercetin inhibited GFAP in the satellite glial cells of the ipsilateral L5 DRG on day 7 compared to the control group. Quercetin suppressed the development of neuropathic pain through a mechanism partly involving the inhibition of satellite glial cells. As its safety is well established, quercetin has great potential for clinical use in pain treatment.

DOI： 10.18926/AMO/56243

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Norepinephrine-induced downregulation of GLT-1 mRNA in rat astrocytes. Reviewed International journal

Kurita M, Matsuoka Y, Nakatsuka K, Ono D, Muto N, Kaku R, Morimatsu H

Biochemical and biophysical research communications 504 ( 1 ) 103 - 108 2018.9

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AIM OF THE RESEARCH: Glutamate transporter-1 (GLT-1; also known as excitatory amino acid transporter 2) plays an important role in the maintenance of glutamate homeostasis in the synaptic cleft. Downregulation of GLT-1 in the spinal cord has been reported in chronic pain models, which suggests that GLT-1 is involved in the development of chronic pain. However, the mechanism by which GLT-1 is downregulated in the spinal cord is still unknown. We hypothesized that norepinephrine is involved in the regulation of GLT-1. The aim of this study was to investigate the effect of norepinephrine on GLT-1 expression in cultured astrocytes. METHODS: This study involved both in vivo and in vitro experiments. We first validated changes in GLT-1 mRNA expression in the spinal cord of rats with spared nerve injury (SNI) using real-time RT-PCR. Next, cultured primary astrocytes from the rat spinal cord were stimulated with norepinephrine, and GLT-1 mRNA was subsequently quantitated. RNB cells, an astrocytic cell line, were also stimulated with norepinephrine and other α-adrenoceptor agonists. RESULTS: SNI resulted in bilateral downregulation of GLT-1 in rat spinal cord. The in vitro study showed that norepinephrine and phenylephrine dose-dependently downregulated GLT-1 in primary astrocytes and RNB cells. Furthermore, the effect of norepinephrine was reversed by an α-adrenoceptor antagonist. CONCLUSION: Norepinephrine downregulates GLT-1 mRNA expression in astrocytes via the α1-adrenoceptor. Our results provide new insight into the mechanisms involved in downregulation of GLT-1 in the chronic pain models.

DOI： 10.1016/j.bbrc.2018.08.137

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Perioperative Management of a Child With Glucose Transporter Type 1 Deficiency Syndrome: A Case Report. Reviewed International journal

Yoshida T, Shimizu K, Suzuki S, Matsuoka Y, Morimatsu H

A&A practice 11 ( 2 ) 35 - 37 2018.7

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Glucose transporter type 1 deficiency syndrome (GLUT1DS) causes central nervous system dysfunction including intractable epilepsy caused by impaired glucose transport to the brain. To prevent convulsions and maintain an energy source for the brain in patients with GLUT1DS, the maintenance of adequate ketone body concentrations, compensation of metabolic acidosis, and reduction of surgical stress are essential. We here report the perioperative management of a child with GLUT1DS.

DOI： 10.1213/XAA.0000000000000727

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胸腺腫摘出術後の抜管時に冠動脈攣縮から心停止に至った1例 Reviewed

吹田晃享, 清水一好, 金澤伴幸, 松岡義和, 森松博史

日本臨床麻酔学会誌 38 ( 2 ) 142 - 147 2018.3

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DOI： 10.2199/jjsca.38.142

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Prolonged-duration pulsed radiofrequency is associated with increased neuronal damage without further antiallodynic effects in neuropathic pain model rats Reviewed International journal

Arakawa Kyosuke, Kaku Ryuji, Kurita Masako, Matsuoka Yoshikazu, Morimatsu Hiroshi

JOURNAL OF PAIN RESEARCH 11 2645 - 2651 2018

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DOI： 10.2147/JPR.S168064

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レボチロキシン内服中止により気管切開後気管狭窄が増悪した慢性甲状腺炎の1例 Reviewed

名原功, 清水一好, 片山明, 川出健嗣, 日笠友起子, 林真雄, 松岡義和, 森松博史

ICUとCCU 40 ( 9 ) 653 - 657 2016.9

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Other Link： http://search.jamas.or.jp/link/ui/2016359621
Perioperative Management Center (PERIO) for Neurosurgical Patients Reviewed

Takao Yasuhara, Tomohito Hishikawa, Takashi Agari, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Masahiro Kameda, Aiko Shinko, Joji Ishida, Masafumi Hiramatsu, Motomu Kobayashi, Yoshikazu Matsuoka, Toshihiro Sasaki, Yoshihiko Soga, Reiko Yamanaka, Takako Ashiwa, Akemi Arioka, Yasuko Hashimoto, Ayasa Misaki, Yuriko Ishihara, Machiko Sato, Hiroshi Morimatsu, Isao Date

NEUROLOGIA MEDICO-CHIRURGICA 56 ( 9 ) 574 - 579 2016

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DOI： 10.2176/nmc.oa.2016-0085

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The inhibitory effect of locally injected dexmedetomidine on carrageenan-induced nociception in rats Reviewed

Yuka Honda, Hitoshi Higuchi, Yoshikazu Matsuoka, Akiko Yabuki-Kawase, Minako Ishii-Maruhama, Yumiko Tomoyasu, Shigeru Maeda, Hiroshi Morimatsu, Takuya Miyawaki

EUROPEAN JOURNAL OF PHARMACOLOGY 764 215 - 219 2015.10

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DOI： 10.1016/j.ejphar.2015.06.054

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Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model Reviewed

Naoto Tomotsuka, Ryuji Kaku, Norihiko Obata, Yoshikazu Matsuoka, Hirotaka Kanzaki, Arata Taniguchi, Noriko Muto, Hiroki Omiya, Yoshitaro Itano, Tadasu Sato, Hiroyuki Ichikawa, Satoshi Mizobuchi, Hiroshi Morimatsu

JOURNAL OF PAIN RESEARCH 7 415 - 423 2014

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DOI： 10.2147/JPR.S63527

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Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia Reviewed

Satoshi Mizobuchi, Hirotaka Kanzaki, Hiroki Omiya, Yoshikazu Matsuoka, Norihiko Obata, Ryuji Kaku, Hirochika Nakajima, Mamoru Ouchida, Kiyoshi Morita

JOURNAL OF PAIN RESEARCH 6 87 - 94 2013

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DOI： 10.2147/JPR.S40967

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Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model Reviewed

Satoshi Mizobuchi, Yoshikazu Matsuoka, Norihiko Obata, Ryuji Kaku, Yoshitaro Itano, Naoto Tomotsuka, Arata Taniguchi, Hiroyuki Nishie, Hirotaka Kanzaki, Mamoru Ouchida, Kiyoshi Morita

ACTA MEDICA OKAYAMA 66 ( 3 ) 285 - 289 2012.6

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DOI： 10.18926/AMO/48569

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Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands Reviewed

Maho Kinoshita, Yoshikazu Matsuoka, Takeshi Suzuki, Jennifer Mirrielees, Jay Yang

BRAIN RESEARCH 1452 1 - 9 2012.5

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DOI： 10.1016/j.brainres.2012.02.070

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SELECTIVE INHIBITION OF EXTRACELLULAR SIGNAL-REGULATED KINASES 1/2 BLOCKS NERVE GROWTH FACTOR TO BRAIN-DERIVED NEUROTROPHIC FACTOR SIGNALING AND SUPPRESSES THE DEVELOPMENT OF AND REVERSES ALREADY ESTABLISHED PAIN BEHAVIOR IN RATS Reviewed

Y. Matsuoka, J. Yang

NEUROSCIENCE 206 224 - 236 2012.3

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DOI： 10.1016/j.neuroscience.2012.01.002

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Decoy strategy targeting the brain-derived neurotrophic factor exon I to attenuate tactile allodynia in the neuropathic pain model of rats Reviewed

Norihiko Obata, Satoshi Mizobuchi, Yoshitaro Itano, Yoshikazu Matsuoka, Ryuji Kaku, Naoto Tomotsuka, Kiyoshi Morita, Hirotaka Kanzaki, Mamoru Ouchida, Masataka Yokoyama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 408 ( 1 ) 139 - 144 2011.4

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DOI： 10.1016/j.bbrc.2011.03.137

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Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion Reviewed

Megumi Omori, Masataka Yokoyama, Yoshikazu Matsuoka, Hiroyuki Kobayashi, Satoshi Mizobuchi, Yoshitaro Itano, Kiyoshi Morita, Hiroyuki Ichikawa

BRAIN RESEARCH 1219 26 - 31 2008.7

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DOI： 10.1016/j.brainres.2008.03.040

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Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model Reviewed

Hiroyuki Kobayashi, Masataka Yokoyama, Yoshikazu Matsuoka, Megurni Omori, Yoshitaro Itano, Rhuji Kaku, Kiyoshi Morita, Hiroyuki Ichikawa

BRAIN RESEARCH 1206 13 - 19 2008.4

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DOI： 10.1016/j.brainres.2007.12.004

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Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF Reviewed

Yoshikazu Matsuoka, Masataka Yokoyama, Hiroyuki Kobayashi, Megurni Omori, Yoshitaro Itano, Kiyoshi Morita, Hiroki Mori, Tohru Nakanishi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 362 ( 3 ) 682 - 688 2007.10

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DOI： 10.1017/j.bbrc.2007.08.022

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Altered response to formalin by L5 spinal nerve ligation in rats: A behavioral and molecular study Reviewed

Ryuji Kaku, Masataka Yokoyama, Hiroyuki Kobayashi, Yoshikazu Matsuoka, Tetsufumi Sato, Satoshi Mizobuchi, Yoshitaro Itano, Kiyoshi Morita

ANESTHESIA AND ANALGESIA 104 ( 4 ) 936 - 943 2007.4

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DOI： 10.1213/01.ane.0000258762.22607.15

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LiSA2025年9月号症例ライブラリー：多職種チームで術前状態を最適化せよ

福田智美, 松岡義和（ Role： Joint author , 呼吸機能と運動機能が低下した高齢食道癌患者）

2025.9

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救急・集中治療 Vol.35 No.2 輸液管理のすべて —研修医からの質問257—

鈴木武志（ Role： Contributor , ロボット支援下泌尿器科手術患者の周術期輸液管理）

総合医学社 2023.8

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確実に身につく心臓カテーテル検査の基本とコツ : 冠動脈造影所見+シェーマで、血管の走行と病変が読める!

中川, 義久, 松岡義和, 幡芳樹（中心静脈穿刺）

羊土社 2023.4 （ ISBN:9784758113007 ）

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救急・集中治療 Vol.33/No.2 輸液管理 2021-’22 —ガイドライン，スタンダード，論点そして私見—

鈴木武志（ Role： Contributor , 脳動脈瘤破裂患者(クリッピング術施行)の輸液管理）

総合医学社 2021.6

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LiSA 2020年別冊秋号周術期管理 PERIO 10年を振り返って

松岡義和、森松博史（ Role： Contributor）

2020.10

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術前術後のハイリスク薬 : 常用薬・持参薬・術前休止薬・術前術後使用薬 : はや調べノート : これだけは押さえておきたい : 薬がわかる!ケアにいかせる!

小林, 求（ Role： Contributor）

メディカ出版 2016.2 （ ISBN:9784840457569 ）

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Total pages：167p Language：Japanese

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まれな疾患の麻酔A to Z

高崎, 眞弓, 河本, 昌志, 木内, 恵子, 白神, 豪太郎, 萩平, 哲（ Role： Contributor）

文光堂 2015.5 （ ISBN:9784830628276 ）

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確実に身につく心臓カテーテル検査の基本とコツ : 冠動脈造影所見+シェーマで、血管の走行と病変が読める!

中川, 義久（ Role： Contributor）

羊土社 2014.3 （ ISBN:9784758107518 ）

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Total pages：357p Language：Japanese

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確実に身につく心臓カテーテル検査の基本とコツ : 冠動脈造影所見+シェーマで, 血管の走行と病変が読める!

中川, 義久（ Role： Contributor）

羊土社 2009.7 （ ISBN:9784758106672 ）

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最新!麻酔のテクニック : 器材と技術の完全マスター

佐藤, 哲文（ Role： Contributor）

総合医学社 2009.7 （ ISBN:9784883786015 ）

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MISC

レミフェンタニル投与時のシリンジポンプへの自動体重送信機能追加の評価

小坂順子, 松岡義和, 森松博史

医工学治療 36 ( Suppl. ) 204 - 204 2024.5

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Preoperative assessment of patients with respiratory complications

松岡義和, 清水達彦, 森松博史

日本麻酔科学会学術集会(Web) 71st 2024

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チーム医療効果的な周術期管理チーム介入を見据えた高齢大腸癌患者の術前機能評価の有用性

寺石文則, 庄司良平, 松三雄騎, 重安邦俊, 近藤喜太, 田村利枝, 松岡義和, 藤原俊義

日本大腸肛門病学会雑誌 76 ( 9 ) A100 - A100 2023.9

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慢性疼痛発症に関与する炎症・侵害受容増幅因子HMGB1の血中動態解析に基づく客観的評価法の確立慢性疼痛患者の診療・治療と臨床研究

森松博史, 松岡義和, 荒川恭佑, 妹尾悠祐

慢性疼痛発症に関与する炎症・侵害受容増幅因子HMGB1の血中動態解析に基づく客観的評価法の確立令和4年度総括・分担研究報告書(Web) 2023

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高齢者に対する大腸がん治療の個別化を考える周術期管理チーム介入により高齢Frail大腸癌患者に対する手術の安全性は向上したか

寺石文則, 庄司良平, 賀島肇, 松三雄騎, 重安邦俊, 近藤喜太, 黒田新士, 香川俊輔, 松岡義和, 森松博史, 藤原俊義

日本癌治療学会学術集会抄録集 60回 OWS9 - 3 2022.10

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レミフェンタニル投与時のシリンジポンプへの自動理想体重送信機能追加の評価

小坂順子, 松岡義和, 森松博史

日本臨床麻酔学会誌 42 ( 6 ) 2022

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Changes in hyaluronic acid synthetase expression in the fascia of rat model of chemotherapy-induced peripheral neuropathy

王瑞林, 松岡義和, 須江宣俊, 坪井千佳, 賀来隆治, 森松博史

日本麻酔科学会学術集会(Web) 69th 2022

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術中に一過性ST上昇を認め,術後に冠動脈攣縮から心停止に至った頭頚部手術の一例

岸田牧子, 吉田翼, 松岡義和, 森松博史

日本臨床麻酔学会誌 42 ( 6 ) 2022

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Identification of the TRP channel involved in thermosensitivity of microglial motility

西本れい, 西本れい, 松岡義和, 富永真琴

日本麻酔科学会学術集会(Web) 69th 2022

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早期治療介入した産後発症のSystemic capillary leak syndrome

坂本里沙, 林真雄, 駿河磨矢, 佐倉孝信, 西本れい, 山之井智子, 黒田浩佐, 鈴木聡, 松岡義和, 森松博史

日本集中治療医学会学術集会(Web) 48th 2021

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重度呼吸機能障害のあるハイリスク食道癌患者に対する多職種介入による長期術前管理

廣川万里子, 板垣栞, 田村利枝, 三宅裕高, 福田智美, 松岡義和, 小林求, 森松博史

日本臨床麻酔学会誌 40 ( 6 ) S275 - S275 2020.10

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【周術期管理】(PART5)周術期チーム医療のこれから PERIO 10年を振り返って

松岡義和, 森松博史

LiSA 別冊 27 ( 別冊'20秋号 ) 287 - 289 2020.9

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術後の肺血栓塞栓症発生率と重症化に対する加齢の影響

松岡義和, 中塚洸輔, 倉迫直子, 青江尚美, 森松博史

日本老年麻酔学会プログラム・抄録集 32回 68 - 68 2020.1

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αアドレナリン受容体刺激によるGLT-1発現の低下が慢性痛モデルラットのmirror image pain発症に関係する

中塚洸輔, 松岡義和, 栗田真佐子, 賀来隆治, 森松博史

日本麻酔科学会学術集会(Web) 67th 2020

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早期治療介入した産後発症のSystemic capillary leak syndrome

坂本里沙, 林真雄, 駿河磨矢, 佐倉孝信, 西本れい, 山之井智子, 黒田浩佐, 鈴木聡, 松岡義和, 森松博史

日本集中治療医学会学術集会(Web) 47th 2020

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穿通胎盤遺残の管理にThromboelastographyを使用した一例

西本れい, 廣井一正, 松岡義和, 日笠友起子, 白川拓, 坪井千佳, 小坂順子, 清水一好, 賀来隆治, 森松博史

日本集中治療医学会学術集会(Web) 47th 2020

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食道胃接合部癌に対する観音開き法鏡視下再建中、心臓圧排を誘因として心室頻拍とST上昇が生じた1症例

藤井彩加, 清水達彦, 角森雅樹, 谷真規子, 松岡義和, 森松博史

日本臨床麻酔学会誌 39 ( 6 ) S313 - S313 2019.10

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硬膜外麻酔下血腫減量術が有効であった巨大慢性拡張性胸腔内血腫の一症例

五反田倫子, 小林求, 松岡勇斗, 廣井一正, 松岡義和, 森松博史

日本臨床麻酔学会誌 38 ( 6 ) S340 - S340 2018.10

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Tチューブ挿入中の術中人工呼吸管理にForgatyカテーテルを使用した一症例

根ヶ山諒, 岡原修司, 松岡義和, 塩路直弘, 熊代美香, 金澤伴幸, 清水一好, 岩崎達雄, 森松博史

日本小児麻酔学会誌 24 ( Suppl. ) 161 - 161 2018.10

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神経麻酔の多職種連携岡山大学病院における脳外科症例に対する周術期管理センターの取り組み

松崎孝, 松岡義和, 谷西秀紀, 賀来隆治, 小林求, 田村利枝, 足羽孝子, 安原隆雄, 伊達勲, 森松博史

日本神経麻酔集中治療学会プログラム・抄録集 22回 25 - 26 2018.6

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本邦における新規医療麻薬ヒドロモルフォンの特性の解析:他オピオイド製剤の特性との比較検討を通して

真鍋星, 真鍋星, 真鍋星, 宮野加奈子, 松岡義和, 佐藤哲文, 森松博史, 上園保仁, 上園保仁

日本麻酔科学会学術集会(Web) 65th 2018

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浸潤性胸腺腫摘出術後の抜管時に冠動脈攣縮から心停止に至った一例

吹田晃享, 松岡義和, 金澤伴幸, 清水一好, 森松博史

日本臨床麻酔学会誌 36 ( 6 ) S354 - S354 2016.10

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iPS細胞から2型肺胞上皮細胞への分化誘導

林真雄, 神崎浩孝, 松岡義和, 森松博史

日本集中治療医学会雑誌 23 ( Suppl. ) 399 - 399 2016.1

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脊髄腫瘍摘出術後に気脳症・頭蓋内出血を認めた一例

合田慶介, 小畑ダニエル, 金澤伴幸, 末盛智彦, 松岡義和, 佐々木俊弘, 清水一好, 森松博史

日本臨床麻酔学会誌 35 ( 6 ) S265 - S265 2015.10

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治療薬内服中断による著明な甲状腺腫大に気管狭窄を合併した一症例

名原功, 清水一好, 片山明, 林真雄, 松岡義和, 森松博史

日本臨床麻酔学会誌 34 ( 6 ) S343 - S343 2014.10

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小児全身型重症筋無力症の麻酔経験

西田静香, 小林求, 日笠友起子, 金澤伴幸, 松岡義和, 森松博史

日本臨床麻酔学会誌 34 ( 6 ) S294 - S294 2014.10

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腹臥位胸腔鏡下食道切除術中に大量出血による心停止をきたしたが後遺症なく救命し得た1例

植村真弓, 小林求, 川西裕之, 岡原修司, 松岡義和, 森松博史

日本臨床麻酔学会誌 33 ( 6 ) S240 - S240 2013.10

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ラット骨がんモデルにおける腫瘍局所での神経成長因子(NGF)の発現

友塚直人, 谷口新, 松岡義和, 賀来隆治, 溝渕知司, 森田潔

日本ペインクリニック学会誌 20 ( 1 ) 77 - 77 2013.2

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脳脊髄液減少症患者における脳脊髄液中シスタチンC濃度

小幡典彦, 松岡義和, 友塚直人, 石川慎一, 板野義太郎, 横山正尚

PAIN RESEARCH 24 ( 2 ) 82 - 82 2009.7

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【最新!麻酔のテクニック器材と技術の完全マスター】術後管理・集中治療 PCA(Patient Controlled Analgesia)

松岡義和, 佐藤健治

麻酔科学レクチャー 1 ( 2 ) 501 - 503 2009.7

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ラット炎症性疼痛モデルにおけるBDNFノックダウンデコイの疼痛抑制効果

小幡典彦, 松岡義和, 板野義太郎, 横山正尚

PAIN RESEARCH 24 ( 2 ) 95 - 95 2009.7

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培養DRGニューロンにおけるNGF刺激下でのASIC3およびTRPV1 mRNAの発現変化

松岡義和, 大森恵, 板野義太郎, 横山正尚

PAIN RESEARCH 23 ( 2 ) 105 - 105 2008.7

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脊髄神経結紮が酢酸刺激による疼痛行動に及ぼす変化に関する研究

大森恵, 小林浩之, 松岡義和, 板野義太郎, 横山正尚

PAIN RESEARCH 23 ( 2 ) 104 - 104 2008.7

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炎症性疼痛においてBDNF遺伝子は後根神経節からプロモーター選択的に発現誘導される

松岡義和, 横山正尚, 小林宏行, 大森恵, 板野義太郎, 森田潔, 森宏樹, 中西徹

日本薬学会年会要旨集 128年会 ( 3 ) 37 - 37 2008.3

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BIPAPで酸素化が維持できない重症劇症肺炎に対しairway pressure release ventilation(APRV)が奏功した1例

松岡義和, 山本公三

日本集中治療医学会雑誌 15 ( Suppl. ) 206 - 206 2008.1

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慢性疼痛モデルにおけるラット後根神経節のASIC3発現に関する研究

大森恵, 小林浩之, 松岡義和, 板野義太郎, 横山正尚

PAIN RESEARCH 22 ( 2 ) 87 - 87 2007.7

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第5腰神経結紮(L5SNL)モデルにおけるフォルマリンに対する疼痛行動変化

賀来隆治, 小林浩之, 松岡義和, 板野義太郎, 溝渕知司, 横山正尚, 森田潔

PAIN RESEARCH 21 ( 2 ) 50 - 50 2006.7

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第5腰神経結紮(L5SNL)モデルにおけるフォルマリンに対する疼痛行動変化の脊髄での機序の検討

賀来隆治, 小林浩之, 松岡義和, 板野義太郎, 溝渕知司, 横山正尚, 森田潔

PAIN RESEARCH 20 ( 2 ) 70 - 70 2005.7

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炎症性疼痛モデルで後根神経節に発現するmultiple brain-derived neurotrophic factor transcriptの半定量解析

松岡義和, 小林浩之, 賀来隆治, 板野義太郎, 溝渕知司, 横山正尚, 森田潔

PAIN RESEARCH 20 ( 2 ) 71 - 71 2005.7

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第5腰神経結紮(L5SNL)モデルで後根神経節に発現するmutiple brain-derived neurotrophic factor(BDNF)transcriptの半定量解析

小林浩之, 松岡義和, 賀来隆治, 溝渕知司, 板野義太郎, 横山正尚, 森田潔

PAIN RESEARCH 20 ( 2 ) 71 - 71 2005.7

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治療に難渋した急性心筋炎の1症例

竹中央, 松岡義和, 白石建輔, 熊代博文, 金岡祐司, 石井智子, 實金健, 森本直樹, 杉山雅俊

日本集中治療医学会雑誌 10 ( Suppl. ) 191 - 191 2003.1

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術後入院経過中に発症したARDS 6症例の検討

高島武煥, 松岡義和, 新井美奈子, 藤井桂子, 安藤英二, 平崎盟人, 松下幹晴, 小野剛, 小西英毅, 瀬戸甲蔵

日本集中治療医学会雑誌 9 ( 1Suppl. ) 120 - 120 2002.1

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当院における術後病棟患者のICU緊急入室例

松下幹晴, 高島武煥, 松岡義和, 新井美奈子, 藤井桂子, 安藤英二, 小原祐子, 平崎盟人, 小野剛, 松田力哉

日本集中治療医学会雑誌 9 ( 1Suppl. ) 140 - 140 2002.1

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シルデナフィル服用によると思われた心室細動の1症例

松岡義和, 高島武煥, 小野剛, 松田力哉, 瀬戸甲蔵

蘇生 20 ( 3 ) 254 - 254 2001.9

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下肢深部静脈血栓症を合併した卵巣腫瘍摘出術周術期管理の1症例

松下幹晴, 松岡義和, 高島武煥, 安藤英二, 小原祐子, 平崎盟人, 小野剛, 小西英毅, 瀬戸甲蔵, 松田力哉

麻酔 50 ( 8 ) 924 - 924 2001.8

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臨床経過よりToxic shock syndrome(TSS)が疑われ,エンドトキシン吸着及びCHDFが有効であった1例

松岡義和, 森松博史, 藤井洋泉, 奥格, 長野修, 松三昌樹, 片山浩, 平川方久

日本臨床麻酔学会誌 20 ( 8 ) S321 - S321 2000.9

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切迫早産,妊娠中毒症にて加療中に肺水腫を合併し呼吸不全に陥った1例

清水啓子, 小坂誠, 大森恵, 松岡義和, 五藤恵次, 森田潔, 平川方久

日本集中治療医学会雑誌 7 ( Suppl. ) 196 - 196 2000.1

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Presentations

ハイリスク手術の術前評価と周術期管理 Invited

松岡義和

第68回関西胸部外科学会学術集会 2025.6.19

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Event date： 2025.6.19 - 2025.6.20

Language：Japanese Presentation type：Oral presentation (invited, special)

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Changes in intracellular Mu-opioid Receptor Signal Activity During Opioid Switching

Keishi Kawano, Sei Manabe, Yoshikazu Matsuoka, Hiroshi Morimatsu

International Anesthesia Research Society 2025 Annual Meeting 2025.3.21

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Event date： 2025.3.20 - 2025.3.23

Language：English Presentation type：Poster presentation

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Different expression patterns of BDNF mRNA in DRG and spinal cord in a new chronic postsurgical pain model in rats

Nobutaka Sue, Yoshikauz Matsuoka, Chika Tsuboi, Hiroshi Morimatsu

International Anesthesia Research Society 2025 Annual Meeting 2025.3.21

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Event date： 2025.3.20 - 2025.3.23

Language：English Presentation type：Poster presentation

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Prospective observational study on sleep quality in post-operative patients with oesophageal cancer using a wearable device

Yoshikazu Kimura, Yoshikazu Matsuoka, Hiroshi Morimatsu, Takahiro Yamane, Mizuki Morita, Naomi Maeda, Shunsuke Tanabe, Kazuhiro Noma

International Anesthesia Research Society 2025 Annual Meeting 2025.3.21

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Event date： 2025.3.20 - 2025.3.23

Language：English Presentation type：Poster presentation

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食道癌術後患者における睡眠の質に関する前向き観察研究

木村貴一, 山根卓大, 前田直見, 田邊俊介, 野間和広, 松岡義和, 森田瑞樹, 森松博史

第52回日本集中治療医学会学術集会 2025.3.16

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Event date： 2025.3.14 - 2025.3.16

Language：Japanese Presentation type：Oral presentation (general)

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高齢がん患者に対するがん診療高齢大腸癌患者における主観的包括的栄養評価(SGA)の有用性単施設前向き観察研究

寺石文則, 吉田有佑, 庄司良平, 松三雄騎, 重安邦俊, 近藤喜太, 香川俊輔, 田村利枝, 松岡義和, 藤原俊義

日本癌治療学会学術集会抄録集 2024.10 (一社)日本癌治療学会

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Event date： 2024.10

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Preoperative Intervention and Multidirectional Risk Assessment for Significant Impairment of Respiratory Function in Esophagectomy

Matsushima M., Shimizu T., Yamashita K., Matsuoka Y., Morimatsu H.

International Anesthesia Research Society 2024 Annual Meeting 2024

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Event date： 2024.5.17 - 2024.5.19

Language：English Presentation type：Poster presentation

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Temperature drives mouse microglia via thermosensitive TRPV4

Nishimoto R., Matsuoka Y., Tominaga M.

International Anesthesia Research Society 2024 Annual Meeting

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Event date： 2024.5.17 - 2024.5.19

Language：English Presentation type：Poster presentation

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Long term assessment of quality of life (QOL) after the surgery for malignant tumor

2023.12.7

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Event date： 2023.12.7 - 2023.12.9

Language：Japanese Presentation type：Oral presentation (general)

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内視鏡下副鼻腔手術における水中下後鼻神経切断操作中に灌流生理食塩水を誤嚥した１症例

坂本里沙, 松岡義和, 牧原靖一郎, 森松博史

日本麻酔科学会中国四国支部第60回学術集会 2023.9.9

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Event date： 2023.9.9

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ロボット支援腹腔鏡下直腸切除術中のインドシアニングリーンによるKounis症候群の一症例

横山和輝松岡義和中村龍寺石文則高橋孝英森松博史

日本麻酔科学会中国四国支部第60回学術集会 2023.9.9

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Event date： 2023.9.9

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低肺機能に対して多角的な術前評価に基づく集学的管理によりロボット支援下食道手術において周術期呼吸器合併症を回避できた一症例

山下航矢, 清水達彦, 成谷俊輝, 小坂順子, 松岡義和, 森松博史

日本麻酔科学会中国四国支部第60回学術集会 2023.9.9

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Event date： 2023.9.9

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温度制御下タイムラプスイメージングを用いたTRPM4遺伝子欠損マウスミクログリアの運動解析

西本れい, 松岡義和, 富永真琴

日本生理学会第100回記念大会 2023.3.14

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Event date： 2023.3.14 - 2023.3.16

Presentation type：Poster presentation

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術中に一過性ST上昇を認め,術後に冠動脈攣縮から心停止に至った頭頚部手術の一例

岸田牧子, 吉田翼, 松岡義和, 森松博史

日本臨床麻酔学会 2022.11.12

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Event date： 2022.11.11 - 2022.11.12

Language：Japanese Presentation type：Oral presentation (general)

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レミフェンタニル投与時のシリンジポンプへの自動理想体重送信機能追加の評価

小坂順子, 松岡義和, 森松博史

日本臨床麻酔学会 2022.11.12

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Event date： 2022.11.11 - 2022.11.12

Language：Japanese

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高齢者に対する大腸がん治療の個別化を考える周術期管理チーム介入により高齢Frail大腸癌患者に対する手術の安全性は向上したか

寺石文則, 庄司良平, 賀島肇, 松三雄騎, 重安邦俊, 近藤喜太, 黒田新士, 香川俊輔, 松岡義和, 森松博史, 藤原俊義

第60回日本癌治療学会 2022.10.20

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Event date： 2022.10.20 - 2022.10.22

Presentation type：Symposium, workshop panel (nominated)

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経肛門的直腸間膜切除術 (taTME) 施行中に CO2 塞栓を疑った一例

横北沙織, 依田智美, 小野大輔, 松岡義和, 森松博史

日本麻酔科学会中国・四国支部第59回学術集会 2022.9.2

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Event date： 2022.9.2 - 2022.10.3

Language：Japanese Presentation type：Poster presentation

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A case of TIVA with remimazolam for neonate using EEG monitoring

2022年9月2日(金)～10月3日(月) 2022.9.2

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Event date： 2022.9.2 - 2022.10.3

Language：Japanese Presentation type：Poster presentation

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Identification of the TRP channel involved in thermosensitivity of microglial motility

2022.6.16

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Event date： 2022.6.16 - 2022.6.18

Language：English Presentation type：Poster presentation

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Changes in hyaluronic acid synthetase expression in the fascia of rat model of chemotherapy-induced peripheral neuropathy

2022.6.16

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Event date： 2022.6.16 - 2022.6.18

Language：English Presentation type：Poster presentation

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早期治療介入した産後発症のSystemic capillary leak syndrome

坂本里沙, 林真雄, 駿河磨矢, 佐倉孝信, 西本れい, 山之井智子, 黒田浩佐, 鈴木聡, 松岡義和, 森松博史

第47回日本集中治療医学会学術集会 2020.3.6

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Event date： 2020.3.6

Language：Japanese Presentation type：Oral presentation (general)

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術後の肺血栓塞栓症発生率と重症化に対する加齢の影響

松岡義和, 中塚洸輔, 倉迫直子, 青江尚美, 森松博史

第32回日本老年麻酔学会 2020.2.9

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Event date： 2020.2.8 - 2020.2.9

Language：Japanese Presentation type：Oral presentation (general)

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視野の広さで選ぶビデオ喉頭鏡:各製品の比較と検討

神原晴樹, 松岡義和

日本臨床麻酔学会第44回大会 2024.11.21

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Presentation type：Oral presentation (general)

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腹腔鏡下結腸・直腸癌手術における局所浸潤麻酔と伝達麻酔の術後疼痛の比較検討

織田みちる, 松岡義和, 伊藤慶昭, 森松博史

日本臨床麻酔学会第44回大会 2024.11.21

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高齢胃癌患者の術前評価における多職種へのタスクシフト・シェアのあり方 Invited

板垣栞, 垣内慶彦, 田村利枝, 廣川万里子, 物部さおり, 安東智恵, 猪田宏美, 賀島肇, 菊地覚次, 黒田新士, 松岡義和, 香川俊輔, 森松博史, 藤原俊義

第62回日本癌治療学会学術集会 2024.10.24

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Presentation type：Symposium, workshop panel (public)

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高齢胃がん患者に対する周術期管理センター介入成果の検討 Invited

田村利枝, 垣内慶彦, 板垣栞, 廣川万里子, 物部さおり, 安東智恵, 猪田宏美, 賀島肇, 菊池覚次, 黒田新士, 松岡義和, 香川俊輔, 森松博史, 藤原俊義

第62回日本癌治療学会学術集会 2024.10.24

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Presentation type：Symposium, workshop panel (nominated)

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周術期管理センターの役割とこれから Invited

松岡義和

日本麻酔科学会中四国支部学術集会 2024.9.14

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Presentation type：Oral presentation (invited, special)

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ラット永久中大脳動脈閉塞後のイソフルラン吸入がアポトーシスに与える影響

谷西秀紀, 真鍋星, 清水裕子, 大森恵美子, 松岡義和, 森松博史

第28回日本神経麻酔集中治療学会 2024.7.13

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Presentation type：Oral presentation (general)

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呼吸器疾患合併症を有する患者の術前評価 Invited

松岡義和, 清水達彦, 森松博史

日本麻酔科学会第71回学術集会 2024.6.7

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Presentation type：Symposium, workshop panel (nominated)

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温度感受性イオンチャネルTRPM4サブタイプの温度嗜好性への関与の検討

西本れい, 松岡義和, 富永真琴

日本麻酔科学会第71回学術集会 2024.6.6

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Presentation type：Oral presentation (general)

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レミフェンタニル投与時のシリンジポンプへの自動理想体重送信機能追加の評価

小坂順子, 松岡義和, 森松博史

医工学治療学会第40回学術大会 2024.5.25

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Presentation type：Oral presentation (general)

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岡山大学病院ICUでのSAH術後管理 Invited

松岡義和

STROKE 2024 2024.3.7

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Presentation type：Symposium, workshop panel (nominated)

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重度呼吸機能障害のあるハイリスク食道癌患者に対する多職種介入による長期術前管理

廣川万里子, 板垣栞, 田村利枝, 三宅裕高, 福田智美, 松岡義和, 小林求, 森松博史

第40回日本臨床麻酔学会 2020.11.6

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Language：Japanese Presentation type：Oral presentation (general)

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αアドレナリン受容体刺激によるGLT-1発現の低下が慢性痛モデルラットのmirror image pain発症に関係する

中塚洸輔, 松岡義和, 栗田真佐子, 賀来隆治, 森松博史

日本麻酔科学会第 67 回学術集会 2020.6.4

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Language：Japanese Presentation type：Oral presentation (general)

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Comparison of two downstream signaling pathways in the μ-opioid receptors activated by several opioids

Sei Manabe, Kanako Miyano, Yusuke Mizobuchi, Eiko Uezono, Kaori Oshima, Akane Komatsu, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Hiroshi Morimatsu, Yasuhito Uezono

2020.3.16

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Language：Japanese

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穿通胎盤遺残の管理にThromboelastographyを使用した一例

西本れい, 廣井一正, 松岡義和, 日笠友紀子, 白川拓, 坪井千佳, 小坂順子, 清水一好, 賀来隆治, 森松博史

第47回日本集中治療医学会学術集会 2020.3.6

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Language：Japanese

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Industrial property rights

疼痛の治療剤およびその利用

板野義太郎, 松岡義和, 大内田守

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Applicant：国立大学法人岡山大学

Application no：特願2010-514435 Date applied：2009.5.14

Patent/Registration no：特許第5545211号 Date registered：2014.5.23 Date issued：2014.5.23

J-GLOBAL

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疼痛の治療剤およびその利用

板野義太郎, 松岡義和, 大内田守

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Applicant：国立大学法人岡山大学

Application no：JP2009058996 Date applied：2009.5.14

Announcement no：WO2009-145067 Date announced：2009.12.3

Publication no：WO2009-145067 Date published：2009123

J-GLOBAL

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Awards

Best presentation award

2023.12 The Japan society for clinical anethesia Long term assessment of quality of life (QOL) after the surgery for malignant tumor

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Fukushima Award

2022.2 Incidence Rates of Postoperative Pulmonary Embolisms in Symptomatic and Asymptomatic Patients, Detected by Diagnostic Images - A Single-Center Retrospective Study.

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最優秀演題

2020.2 日本老年麻酔学会術後の肺血栓塞栓症発生率と重症化に対する加齢の影響

松岡義和

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Award type：Award from Japanese society, conference, symposium, etc. Country：Japan

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2019 ANZICS Best Medical Poster

2019 ANZICS 2019 World Congress of Intensive Care Medicine The incidence of catheter-related venous thromboembolism in synthetic polymer-coated vs. conventional non-coated peripherally inserted central catheters

Matsuoka Y, Matsuoka Y, Suzuki S, Morimatsu H

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日本麻酔科学会中国･四国支部学術集会若手研究奨励発表優秀賞

2008.9 日本麻酔科学会 BDNFノックダウンによるラット炎症性疼痛の抑制

松岡義和

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Research Projects

化学療法誘発性末梢神経障害におけるヒアルロン酸の役割と治療法の開発

Grant number：25K12210 2025.04 - 2028.03

日本学術振興会科学研究費助成事業基盤研究(C)

松岡義和, 荒川恭佑

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Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

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Effect of inhaled argon on neurologic outcome and cerebral TLR activity in permanent MCAO rats

Grant number：23K08381 2023.04 - 2026.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

谷西秀紀, 松岡義和

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Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

本年度はアルゴン吸入を従来からもつ麻酔回路への組み込みの準備に追われた。アルゴン３時間投与に必要な麻酔回路、また流量計の組み込み、また虚血開始後24時間にわたりアルゴンを投与できる環境をつくる予定であったが、専用のベンチが一つであり、そちらを別実験で使用し完遂することを優先したため、本年度は実験に必要な装置を組み立てる段階までしか進めることができなかった。ラット永久中大脳動脈モデルは完成しており、早期にアルゴン吸入のパイロットスタディに入ることが可能である。

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The role of fascia in chemotherapy-induced peripheral neuropathy as a novel therapeutic target

Grant number：22K09094 2022.04 - 2025.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

松岡義和, 荒川恭佑

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Authorship：Principal investigator

Grant amount：\4030000 （ Direct expense: \3100000 、 Indirect expense：\930000 ）

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術後遷延痛における脊髄グルタミン酸トランスポーターの役割に関する検討

Grant number：21K08995 2021.04 - 2024.03

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C)

賀来隆治, 松岡義和

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Grant amount：\3380000 （ Direct expense: \2600000 、 Indirect expense：\780000 ）

Glutamate transporter-1(GLT-1) はアストロサイト特異的グルタミン酸トランスポーターであり、シナプス間隙のグルタミン酸濃度の恒常性を保つ。既存の論文では GLT-1 と慢性痛の関係が研究され、in vitroで Primary astrocyte にα1受容体作動薬を投与すると用量依存性にGLT-1 発現が抑制すること、in vivo で modified Spared Nerve Injury(SNI) モデルラットの両側脊髄で GLT-1 の発現が低下すること、両側脊髄でノルアドレナリンが一過性に増加すること、健側でも疼痛閾値の低下 (mirror image pain, MIP) が生じることが報告されている。MIPの機序として脊髄アストロサイトの GLT-1 発現とアドレナリン受容体の関係を検討した。in vitroの結果では、ノルアドレナリン3μM投与下にフェントラミンを投与すると、GLT-1 発現は完全に回復したが、α1A, α1D 受容体阻害剤投与では、部分的な回復にとどまった。in vivoの結果としては、モデル作成 3 日目に両足底の疼痛閾値低下を認めた。生理食塩水群では10日目まで両側疼痛閾値は改善しなかった。α1受容体阻害剤200μg群では患側疼痛閾値の変化を認めないが、10日目の健側疼痛閾値は改善した。結論としては脊髄アストロサイトのα1受容体刺激によるGLT-1発現の低下がMIPの機序に関与することが示唆された。これらの結果をまとめて、Phentolamine-induced spinal GLT-1 upregulation improve mirror image pain in SNI model rat. Acta Med Okayama 2022 Vol.76, No3, pp.255－63として報告した。

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Splice-variant specific knock-down of Neuregline 1 as a treatment for chemotherapy-induced peripheral neuropathy

Grant number：18K08816 2018.04 - 2021.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

Matsuoka Yoshikazu

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Grant amount：\3770000 （ Direct expense: \2900000 、 Indirect expense：\870000 ）

Chemotherapy-induced peripheral neuropathy (CIPN) is a major adverse effect of the cancer therapy. This study was aimed to study the etiology of CIPN. Neuregline 1 is a glicoprotein and involved in neural regeneration, differenciation. We studied the involvement of Neuregline 1 in the development of CIPN using rat model of CIPN. The rats were injected Vincristin (VCR) intraperitoneally. Mechanical withdrawal thresholds (50% PWT) was assesed by up-down method with von Frey fillaments. VCR injection caused decrease of 50% PWT from day 7 to day 14. We quantitated Neureglin 1 splice variants mRNA in the dorsal root ganglion (DRG) of the rats on day 14. Neuregline 1 splice variatns 1, 2, 3 showed tendencies to decrease.

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Developing drug for neuropathic pain by chemically modified flavonoids targeting MEK

Grant number：25870459 2013.04 - 2016.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)

Matsuoka Yoshikazu

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Grant amount：\3900000 （ Direct expense: \3000000 、 Indirect expense：\900000 ）

The aim of this study was to investigate the effect of quercetin on the neuropathic pain in the rat model. Pre-treatment of neuropathic pain by oral administrated quercetin prevented the development of pain behavior in the rat with spared nerve injury model. On the other hand, post-treatment failed to reverse the pain behavior. Immunohistochemisty and western blotting showed significant suppression of GFAP protein, a marker of astrocyte activation, in dorsal root ganglion in the treated rats. These results showed that the effect of quercetin on the neuropathic pain was mediated by the suppression of activation of satellite glial cells in dorsal root ganglia.

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Basic research of pain control by DNA decoy for brain-derived neurotrophic factor

Grant number：21592008 2009 - 2011

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)

YOKOYAMA Masataka, OBATA Norihiko, MATSUOKA Yoshikazu

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Grant amount：\4420000 （ Direct expense: \3400000 、 Indirect expense：\1020000 ）

We made DNA decoy for brain-derived neurotrophic factor(BDNF) exon-1 that is increased significantly in the spinal level of neuropathic pain model. We administered DNA decoy intrathecally to knock-down BDNF exon-1 in pain model rats, and confirmed that pain response was decreased by DNA decoy.

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Class subject in charge

Practicals: Anesthesiology and Resuscitology （2025academic year） special - その他
Research Projects: Anesthesiology and Resuscitology （2025academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology I （2025academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology II （2025academic year） special - その他
Anesthesiology and Resuscitology （2025academic year） special - その他
Practicals: Anesthesiology and Resuscitology （2024academic year） special - その他
Research Projects: Anesthesiology and Resuscitology （2024academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology I （2024academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology I （2024academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology II （2024academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology II （2024academic year） special - その他
Anesthesiology and Resuscitology （2024academic year） special - その他
Practicals: Anesthesiology and Resuscitology （2023academic year） special - その他
Research Projects: Anesthesiology and Resuscitology （2023academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology I （2023academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology I （2023academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology II （2023academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology II （2023academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology I （2022academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology I （2022academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology II （2022academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology II （2022academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology I （2021academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology I （2021academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology II （2021academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology II （2021academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology I （2020academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology I （2020academic year） special - その他
Research Projects and Practicals: Anesthesiology and Resuscitology II （2020academic year） special - その他
Lecture and Research Projects: Anesthesiology and Resuscitology II （2020academic year） special - その他

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Academic Activities

科学研究費助成事業査読委員

Role(s)：Peer review

2024.11

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Type：Peer review

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日本麻酔科学会企画委員

Role(s)：Planning, management, etc.

2024.8

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Type：Academic society, research group, etc.

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