研究者詳細 - 細川　海音

論文 - 細川　海音

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OCTを用いた分層黄斑円孔と類縁疾患の多面的解析

的場亮, 神崎勇希, 木村修平, 細川海音, 塩出雄亮, 森實祐基

日本眼科学会雑誌 127 ( 臨増 ) 242 - 242 2023年3月

Protrusion of KCNJ13 Gene Knockout Retinal Pigment Epithelium Due to Oxidative Stress-Induced Cell Death. 査読国際誌

Yuki Kanzaki, Hirofumi Fujita, Keita Sato, Mio Hosokawa, Hiroshi Matsumae, Yuki Morizane, Hideyo Ohuchi

Investigative ophthalmology & visual science 63 ( 12 ) 29 - 29 2022年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: This study was performed to elucidate the mechanisms of morphological abnormalities in a Leber congenital amaurosis 16 (LCA16) cell model using KCNJ13 knockout (KO) retinal pigment epithelial cells derived from human iPS cells (hiPSC-RPE). METHODS: In KCNJ13 KO and wild-type hiPSC-RPE cells, ZO-1 immunofluorescence was performed, and confocal images were captured. The area and perimeter of each cell were measured. To detect cell death, ethidium homodimer III (EthD-III) staining and LDH assay were used. Scanning electron microscopy (SEM) was used to observe the cell surface. The expression levels of oxidative stress-related genes were examined by quantitative PCR. To explore the effects of oxidative stress, tert-butyl hydroperoxide (t-BHP) was administered to the hiPSC-RPE cells. Cell viability was tested by MTS assay, whereas oxidative damage was monitored by oxidized (GSSG) and reduced glutathione levels. RESULTS: The area and perimeter of KCNJ13-KO hiPSC-RPE cells were enlarged. EthD-III-positive cells were increased with more dead cells in the protruded region. The KO RPE had significantly higher LDH levels in the medium. SEM observations revealed aggregated cells having broken cell surfaces on the KO RPE sheet. The KCNJ13-deficient RPE showed increased expression levels of oxidative stress-related genes and total glutathione levels. Furthermore, t-BHP induced a significant increase in cell death and GSSG levels in the KO RPE. CONCLUSIONS: We suggest that in the absence of the Kir.7.1 potassium channel, human RPE cells are vulnerable to oxidative stress and ultimately die. The dying/dead cells form aggregates and protrude from the surviving KCNJ13-deficient RPE sheet.

DOI： 10.1167/iovs.63.12.29

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強膜バックリング後に形成された黄斑上膜の検討:OCT en face画像を用いた解析

的場亮, 神崎勇希, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 森實祐基

眼科臨床紀要 15 ( 10 ) 691 - 692 2022年10月

糖尿病黄斑浮腫に対する抗VEGF薬の治療効果に黄斑上膜の合併が及ぼす影響

神崎勇希, 細川海音, 木村修平, 塩出雄亮, 的場亮, 森田哲郎, 森實祐基

糖尿病合併症 36 ( Suppl.1 ) 238 - 238 2022年9月

Bilateral Blunt Ocular Trauma Caused by an Exercise Resistance Band during Muscle Building Exercise for Swimming.

Kanazu Ariyasu, Shuhei Kimura, Ryo Matoba, Mio Morizane Hosokawa, Yusuke Shiode, Shinichiro Doi, Yuki Kanzaki, Yuki Morizane

Acta medica Okayama 76 ( 3 ) 349 - 354 2022年6月

記述言語：英語

An 18-year-old male high school student presented to our clinic with bilateral blunt ocular trauma caused by an exercise resistance band (ERB) during a muscle-building exercise. Best-corrected decimal visual acuities (BCVAs) for right and left eyes were light perception and 0.15, respectively. The right eye was operated 10 days after injury for persistent vitreous hemorrhage, and the left eye 5 months later because of macular hole onset. After 36 months, the right eye showed extensive retinal degeneration (BCVA 0.04), and the left eye macular hole closure (BCVA 1.2). ERBs should be used cautiously as they can cause serious ocular trauma.

DOI： 10.18926/AMO/63747

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網膜細動脈瘤破裂による網膜内出血が網膜感度に及ぼす影響

赤塚陸, 土居真一郎, 木村修平, 塩出雄亮, 細川海音, 的場亮, 神崎勇希, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 171 - 171 2022年3月

光干渉断層計en face画像を用いた分層黄斑円孔関連疾患の解析

三野麻以, 的場亮, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 神崎勇希, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 235 - 235 2022年3月

水泳の筋力トレーニング中にエクササイズバンドによって重度の両眼外傷を来した一例

有安奏, 木村修平, 的場亮, 細川海音, 塩出雄亮, 土居真一郎, 神崎勇希, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 283 - 283 2022年3月

黄斑上膜における最大網膜皺襞深度と黄斑局所網膜電図および網膜層厚との関係

神崎勇希, 的場亮, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 谷川篤宏, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 196 - 196 2022年3月

網膜剥離眼における眼軸長の測定法の検討

木村修平, 後藤保人, 金永圭祐, 細川海音, 塩出雄亮, 土居真一郎, 的場亮, 神崎勇希, 鈴木越治, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 219 - 219 2022年3月

水泳の筋力トレーニング中にエクササイズバンドによって重度の両眼外傷を来した一例

有安奏, 木村修平, 的場亮, 細川海音, 塩出雄亮, 土居真一郎, 神崎勇希, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 283 - 283 2022年3月

網膜細動脈瘤破裂による網膜内出血が網膜感度に及ぼす影響

赤塚陸, 土居真一郎, 木村修平, 塩出雄亮, 細川海音, 的場亮, 神崎勇希, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 171 - 171 2022年3月

黄斑上膜における最大網膜皺襞深度と黄斑局所網膜電図および網膜層厚との関係

神崎勇希, 的場亮, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 谷川篤宏, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 196 - 196 2022年3月

網膜剥離眼における眼軸長の測定法の検討

木村修平, 後藤保人, 金永圭祐, 細川海音, 塩出雄亮, 土居真一郎, 的場亮, 神崎勇希, 鈴木越治, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 219 - 219 2022年3月

光干渉断層計en face画像を用いた分層黄斑円孔関連疾患の解析

三野麻以, 的場亮, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 神崎勇希, 森實祐基

日本眼科学会雑誌 126 ( 臨増 ) 235 - 235 2022年3月

Objective and quantitative estimation of the optimal timing for epiretinal membrane surgery on the basis of metamorphopsia. 国際誌

Yuki Kanzaki, Shinichiro Doi, Ryo Matoba, Sayumi Kanzaki, Shuhei Kimura, Mio M Hosokawa, Yusuke Shiode, Ippei Takasu, Yuki Morizane

Retina (Philadelphia, Pa.) 42 ( 4 ) 704 - 711 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To establish an objective and quantitative biomarker of metamorphopsia in epiretinal membranes (ERMs) and determine the optimal timing for ERM surgery. METHODS: Retrospectively, 172 eyes with ERM were reviewed. Retinal folds due to tangential traction by ERM were visualized by en face optical coherence tomography (OCT). The maximum depth of retinal folds (MDRF) within the parafovea was quantified. Metamorphopsia was quantified by M-CHARTS. The change in the distance between the retinal vessels after ERM surgery and the preoperative total depth of retinal folds between the vessels were quantified using en face OCT and OCT angiography. RESULTS: Significant correlations were observed between preoperative MDRF and M-CHARTS scores before and at 6 months after surgery (r=0.617 and 0.460, respectively; P<0.001) and change in the distance between the retinal vessels after ERM surgery and preoperative total depth of retinal folds between the vessels (r=0.471, P=0.013). The preoperative MDRF values at which M-CHARTS scores were 0.5 before and 6 months after surgery were 69 μm and 118 μm, respectively. CONCLUSION: MDRF is an objective and quantitative biomarker of metamorphopsia in ERM. To maintain patients' quality of vision, ERM surgery may be performed when the preoperative MDRF ranges between 69 and 118 μm.

DOI： 10.1097/IAE.0000000000003401

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Sublingual Gland Carcinoma Revealed by Choroidal Metastasis.

Tetsuro Morita, Yusuke Shiode, Shuhei Kimura, Mio Hosokawa, Shinichiro Doi, Kosuke Takahashi, Ryo Matoba, Yuki Kanzaki, Masahiro Tabata, Yuki Morizane

Acta medica Okayama 75 ( 6 ) 741 - 744 2021年12月

記述言語：英語

A 65-year-old man presented with a 1-week history of left eye distortion. An elevated choroidal lesion covering 6 disc diameters was found in the posterior retina of the left eye. Systemic examination revealed sublingual gland carcinoma and multiple lung metastases, and the diagnosis was choroidal metastasis from sublingual gland carcinoma. Following chemotherapy and radiation therapy, the choroidal lesion shrunk and the patient's visual acuity improved. The patient died 23 months after his first visit. To the best of our knowledge, this is the first reported case of choroidal metastasis from sublingual gland carcinoma.

DOI： 10.18926/AMO/62815

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Assessment of epiretinal membrane formation using en face optical coherence tomography after rhegmatogenous retinal detachment repair. 国際誌

Ryo Matoba, Yuki Kanzaki, Shinichiro Doi, Sayumi Kanzaki, Shuhei Kimura, Mio Morizane Hosokawa, Yusuke Shiode, Kosuke Takahashi, Yuki Morizane

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 259 ( 9 ) 2503 - 2512 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To investigate epiretinal membrane (ERM) formation using en face optical coherence tomography (OCT) after vitrectomy for rhegmatogenous retinal detachment (RRD). METHODS: We retrospectively reviewed the medical records of 64 consecutive eyes (64 patients) with RRD treated by vitrectomy without ERM and internal limiting membrane peeling. ERMs and retinal folds were detected by B-scan and en face imaging. The maximum depth of retinal folds (MDRF) was quantified using en face imaging. ERM severity was staged using B-scan imaging. Main outcome measures were ERM detection rate with B-scan and en face imaging, MDRF, ERM staging, postoperative best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution), and risk factors for ERM formation. RESULTS: The detection rate for ERM formation was significantly higher with en face imaging (70.3%) than with B-scan imaging (46.9%; P = 0.007). There was no significant difference in postoperative BCVA between eyes with ERM formation (0.06 ± 0.26) and those without ERM formation (0.01 ± 0.14; P = 0.298). Forty of 45 (88.9%) eyes with ERM formation were classified as stage 1. Twenty-seven of 45 (60.0%) eyes with ERM formation developed parafoveal retinal folds. The mean MDRF was 27.4 ± 32.2 μm. Multiple retinal breaks and a maximum retinal break size of ≥ 2 disc diameters were significantly associated with ERM formation (P = 0.033 and P = 0.031, respectively). CONCLUSION: Although ERM formation was observed in 70.3% patients after RRD repair, the formed ERM was not severe and had minimal impact on the postoperative visual acuity.

DOI： 10.1007/s00417-021-05118-y

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OCT En face画像を用いた糖尿病黄斑浮腫の分類と黄斑上膜の合併率

森實祐基, 藤原篤之, 神崎勇希, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 的場亮

糖尿病合併症 35 ( Suppl. ) 259 - 259 2021年9月

En Face Image-Based Analysis of Epiretinal Membrane Formation after Surgery for Idiopathic Epiretinal Membrane. 国際誌

Sayumi Kanzaki, Yuki Kanzaki, Shinichiro Doi, Ryo Matoba, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Kosuke Takahashi, Atsushi Fujiwara, Ippei Takasu, Yuki Morizane

Ophthalmology. Retina 5 ( 8 ) 815 - 823 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: To analyze en face epiretinal membrane (ERM) images constructed using swept-source (SS) OCT and to determine the incidence of ERM formation after ERM surgery and its effects on visual function. DESIGN: Retrospective, consecutive observational study. PARTICIPANTS: Consecutive series of 73 eyes (71 patients) with idiopathic ERM that underwent vitrectomy with both ERM and internal limiting membrane (ILM) peeling. METHODS: We retrospectively reviewed the data of the 73 eyes included in the study. During surgery, the ERM was removed as extensively as possible, and the ILM was removed such that the area of ILM peeling was at least larger than the parafoveal area. All patients underwent comprehensive ophthalmologic examinations, including assessments of best-corrected visual acuity and metamorphopsia, before and at 2 weeks and 6 months after the surgery. En face images constructed using SS OCT were used to investigate ERM formation. MAIN OUTCOME MEASURES: The incidence of ERM formation at 6 months after the surgery, effects of ERM formation on visual function, and the relationship between ERM formation and the extent of ERM and ILM peeling. RESULTS: At 6 months after ERM and ILM peeling, 8 eyes (11.0%) showed ERM formation (formation group). Twenty eyes (27.4%) exhibited remnant ERM without ERM formation (remnant group), whereas 45 eyes (61.6%) showed no ERM (no ERM group). In both the remnant and no ERM groups, best-corrected visual acuity and metamorphopsia showed significant improvements after ERM surgery (both P < 0.01); these improvements were not seen in the formation group (P = 0.067 and P = 0.053, respectively). However, no significant differences were found in preoperative and postoperative best-corrected visual acuities and metamorphopsia among the 3 groups. In the formation group, ERM formation occurred only in the area with residual ILM. Most patients who underwent ILM peeling in which the area of the peeling covered the ERM belonged to the no ERM group (97.7%; P < 0.01). CONCLUSIONS: Epiretinal membrane formation does not affect visual function significantly when the area of ILM peeling is larger than the parafoveal area. When the ILM peeling area covers the ERM area, postoperative ERM formation can be prevented.

DOI： 10.1016/j.oret.2020.10.017

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