2026/08/26 更新

写真a

マキモト　サトコ
槇本　怜子
MAKIMOTO SATOKO
所属
学術研究院医療開発領域 助教
職名
助教
外部リンク

学位

  • 医学博士 （ 2016年3月   岡山大学大学院医歯薬学総合研究科 ）

 

論文

  • Risk Factors for Waiting List Mortality in Lung Transplant Candidates With Post-Hematopoietic Stem Cell Transplantation Non-Infectious Pulmonary Complications. 国際誌

    Hisao Higo, Satoru Senoo, Satoko Makimoto, Tomohiro Nagano, Takumi Kondo, Haruchika Yamamoto, Shin Tanaka, Kentaroh Miyoshi, Seiichiro Sugimoto, Shinichi Toyooka, Yoshinobu Maeda, Yosuke Togashi, Nobuaki Miyahara

    Clinical transplantation   40 ( 6 )   e70582   2026年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    BACKGROUND: Late-onset non-infectious pulmonary complications (LONIPCs) following hematopoietic stem cell transplantation (HSCT) are a known indication for need of lung transplantation. This study aimed to clarify the clinical characteristics of patients with LONIPCs after HSCT who were registered for lung transplantation and reveal the risk factors for waiting list mortality. METHODS: We retrospectively reviewed the clinical data of patients with LONIPCs after allogeneic HSCT who were referred to Okayama University Hospital and registered in the Japan Organ Transplant Network for deceased-donor lung transplantation between 2005 and 2023. Pediatric patients aged <18 years at the time of registration were excluded. RESULTS: Thirty-four patients were included in this study. Notably, two distinct phenotypic groups were identified: One with a bronchiolitis obliterans pattern on high-resolution computed tomography and a mixed ventilatory defect, and the other with a pleuroparenchymal fibroelastosis pattern and a restrictive ventilatory defect. The median waiting duration for a deceased-donor lung transplant was 662 days, and 16 patients died during the waiting period. The cumulative incidence of waiting list mortality was 20.6% (95% confidence interval [CI], 8.9%-35.6%) at 1 year and 46.1% (95% CI, 27.8%-62.7%) at 3 years. A history of pneumothorax, greater dyspnea on exertion, and higher serum Krebs von den Lungen-6 levels were associated with an increased risk of waiting list mortality. CONCLUSION: In patients with LONIPCs after HSCT, a history of pneumothorax may be a marker of a poor prognosis and could serve as a criterion for referral of lung transplantation.

    DOI： 10.1111/ctr.70582

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  • MRI Images of a Case of Adenocarcinoma, Human Papillomavirus-Independent, Mesonephric Type, of the Uterine Cervix.

    Yudai Asano, Chika Nishihara, Takahiro Kitayama, Nanako Okawa, Satoko Makimoto, Fumiyo Higaki, Katsuhide Kojima, Hanako Sugihara, Naoyuki Ida, Hiroyuki Yanai, Takao Hiraki

    Acta medica Okayama   79 ( 6 )   463 - 468   2025年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    We present a case of a woman in her 70s who was diagnosed with mesonephric adenocarcinoma of the uterine cervix, following biopsy and surgery. Preoperative MRI revealed a 7-cm, well-defined circumferential cervical mass with left lateral wall predominance, bulging into the uterine cavity and vagina. The lesion showed intermediate signal intensity on T2-weighted images, diffusion restriction, and early contrast enhancement weaker than that of the myometrium, followed by washout on contrast-enhanced imaging. The circumferential growth pattern with the lateral wall predominance and its imaging characteristics may suggest this rare entity be routinely included in the differential diagnosis of cervical cancers.

    DOI： 10.18926/AMO/69850

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  • The Clinical Significance of Interstitial Pneumonia with Autoimmune Features in Cryptogenic Organizing Pneumonia: A Prospective Multicenter Observational Study. 国際誌

    Hisao Higo, Hirohisa Ichikawa, Yukako Arakawa, Yoshihiro Mori, Tomoki Tamura, Shoichi Kuyama, Chiaki Matsumoto, Keisuke Sugimoto, Noboru Hamada, Toshimitsu Suwaki, Junko Itano, Yasushi Tanimoto, Satoru Senoo, Akihiko Taniguchi, Yumi Inukai, Machiko Arita, Satoko Makimoto, Katsuhide Kojima, Takashi Matsushita, Yoshinobu Maeda, Nobuaki Miyahara

    Journal of clinical medicine   13 ( 22 )   2024年11月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Background: There are cases of idiopathic interstitial pneumonias (IIPs) that do not meet the diagnostic criteria for connective tissue disease but have clinical features suggestive of autoimmune process. Interstitial pneumonia with autoimmune features (IPAF) was recently proposed as a research concept for these patients. Although several prospective studies on IPAF have been conducted, its clinical significance in cryptogenic organizing pneumonia (COP) remains unclear. Methods: Patients aged ≥20 years with suspected COP were prospectively enrolled between June 2018 and December 2022. Among the enrolled patients, those diagnosed with COP based on computed tomography (CT) and bronchoalveolar lavage (BAL) findings were compared between the IPAF and non-IPAF groups. Results: A total of 56 patients were enrolled in this study. Of these, 30 were diagnosed with COP and included in the analysis. Clinical and serological features were positive in two and six patients, respectively. Each feature was exclusive, and eight patients (26.7%) were diagnosed with IPAF. There were no differences between the IPAF and non-IPAF groups in terms of clinical features, including BAL findings, laboratory data, CT findings, and clinical course. During the one-year follow-up period, the frequency of COP exacerbation did not differ between the IPAF and non-IPAF groups, and no cases of systemic autoimmune disease or death occurred in either group. Conclusions: The COP characteristics of the IPAF and non-IPAF groups are similar in all aspects, and distinguishing between the two groups may be of little significance.

    DOI： 10.3390/jcm13226870

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  • Remission of hypersensitivity pneumonitis after allogeneic hematopoietic stem cell transplantation. 国際誌

    Yumi Inukai Motokura, Hisao Higo, Chiaki Matsumoto, Mari Uno, Kanako Fujiwara, Toshiki Terao, Satoko Makimoto, Fumiyo Higaki, Ken-Ichi Matsuoka, Fumiaki Tokioka, Yoshinobu Maeda, Nobuaki Miyahara

    Respiratory investigation   62 ( 5 )   759 - 761   2024年9月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A 50-year-old man was diagnosed with hypersensitivity pneumonitis caused by the environment of his bar owing to worsening symptoms, laboratory test results, and computed tomography images after an environmental inhalation challenge test. His hypersensitivity pneumonitis exacerbated despite receiving prednisolone 20 mg/day. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a human leukocyte antigen-matched unrelated donor for myelodysplastic syndrome. No exacerbation of hypersensitivity pneumonitis was observed after HSCT. An environmental inhalation challenge test involving exposure to his bar confirmed the remission of hypersensitivity pneumonitis after HSCT. This case demonstrates that hypersensitivity pneumonitis can be remitted by HSCT.

    DOI： 10.1016/j.resinv.2024.06.007

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  • A Case of Migration of a Hydrogel Spacer for Radiotherapy into the Pulmonary Artery.

    Katsuhide Kojima, Yuka Takahashi, Soichi Sugiyama, Yudai Asano, Nanako Okawa, Satoko Makimoto, Fumiyo Higaki, Toshihiro Iguchi, Takao Hiraki

    Acta medica Okayama   77 ( 6 )   647 - 650   2023年12月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    A 67-year-old man was referred to our hospital for the diagnosis and treatment of prostate cancer. Multidisciplinary discussion led to intensity-modulated radiotherapy preceded by hormone therapy. Before radiotherapy, a biodegradable hydrogel spacer (HS) was placed between the prostate and rectum to reduce radiation injury risk. Three weeks postplacement, pelvic magnetic resonance imaging revealed HS migration into the pelvic vein. Subsequent whole-body contrast-enhanced computed tomography (CECT) revealed HS migration into the pulmonary artery. The patient showed no symptoms or clinical signs. Radiotherapy was completed uneventfully. Complete absorption of the migrated HS was confirmed using CECT images 5 months postplacement.

    DOI： 10.18926/AMO/66157

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  • 【腹部の最新画像情報2023】びまん性に著明な卵殻状石灰化が認められた食道平滑筋腫の1例

    岡部 将仁, 浅野 雄大, 児島 克英, 槇本 怜子, 檜垣 文代, 田中 健大, 平木 隆夫

    臨床放射線   68 ( 5 )   461 - 468   2023年5月

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    記述言語：日本語   出版者・発行元：金原出版(株)  

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  • Heerfordt's Syndrome Associated with Trigeminal Nerve Palsy and Reversed Halo Sign.

    Go Makimoto, Keita Kawakado, Masamoto Nakanishi, Tomoki Tamura, Minori Noda, Satoko Makimoto, Yumiko Sato, Shoichi Kuyama

    Internal medicine (Tokyo, Japan)   60 ( 11 )   1747 - 1752   2021年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Heerfordt's syndrome is a rare subtype of sarcoidosis and features a combination of facial palsy, parotid swelling, and uveitis, associated with a low-grade fever. Cases with two of three symptoms are called "incomplete Heerfordt's syndrome." Heerfordt's syndrome involving other cranial nerve symptoms is relatively rare. We herein report a case of incomplete Heerfordt's syndrome presenting with trigeminal nerve palsy and a reversed halo sign, a rare manifestation of pulmonary sarcoidosis. The histological diagnosis following a biopsy of the parotid gland and endobronchial ultrasound-guided trans-bronchial needle aspiration of the mediastinal lymph nodes was sarcoidosis. The symptoms and lung lesions improved after corticosteroid therapy.

    DOI： 10.2169/internalmedicine.6176-20

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  • Chemoradiotherapy for locally advanced lung cancer patients with interstitial lung abnormalities. 国際誌

    Hisao Higo, Toshio Kubo, Satoko Makimoto, Go Makimoto, Hiroki Ihara, Yoshihisa Masaoka, Takashi Ninomiya, Eiki Ichihara, Kadoaki Ohashi, Akiko Sato, Katsuyuki Hotta, Masahiro Tabata, Nagio Takigawa, Yoshinobu Maeda, Katsuyuki Kiura

    Japanese journal of clinical oncology   49 ( 5 )   458 - 464   2019年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    INTRODUCTION: Although chemoradiotherapy for locally advanced lung cancer has the potential for cure, treatment is avoided in patients with interstitial lung disease because of the risk for severe radiation pneumonitis. Interstitial lung abnormalities (ILA) can be evaluated using high-resolution computed tomography (HRCT) to assess interstitial changes. In this study, we retrospectively examined the feasibility and efficacy of chemoradiotherapy for locally advanced lung cancer patients with ILA. METHODS: Patients who underwent chemoradiotherapy for locally advanced lung cancer at Okayama University Hospital between 2012 and 2015 were reviewed retrospectively. HRCT prior to treatment was evaluated by one pulmonologist and two radiologists using a sequential reading method. RESULTS: Of the 77 patients enrolled in this study, ILA was present in 25 (32.5%) and indeterminate ILA in 24 patients; 28 patients did not have ILA. Desaturation at rest (SpO2 < 95%) and honeycombing on HRCT were not observed in ILA patients. Only one patient with ILA had a low vital capacity (%VC < 80%). Severe radiation pneumonitis (≥Grade 2) occurred in 36.0% of the patients with ILA, but it was controllable; Grade 4 or 5 was not observed. Multivariate analysis showed that >25% of the lung volume receiving >20 Gy was risk factors of severe radiation pneumonitis, but ILA was not. The 2-year survival rates of patients with and without ILA were 56.8% and 74.1%, respectively, but the difference was not significant (P = 0.33). CONCLUSIONS: Chemoradiotherapy was feasible and effective in some patient population with ILA without desaturation, low VC and honeycombing on HRCT.

    DOI： 10.1093/jjco/hyz016

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  • A rapid caliber change in the inferior vena cava during multiphasic contrast-enhanced computed tomography may signal an acute anaphylactic reaction to nonionic contrast medium. 国際誌

    Takayoshi Shinya, Akihiro Tada, Yoshihisa Masaoka, Nanako Ogawa, Satoko Makimoto, Hiroki Ihara, Ryuichiro Fukuhara, Noriaki Akagi, Takao Hiraki, Atsunori Nakao, Susumu Kanazawa

    Radiology case reports   13 ( 5 )   970 - 974   2018年10月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Severe anaphylactic reactions to an intravenous nonionic iodine contrast medium (NICM) are uncommon but can result in permanent morbidity or death if not managed appropriately. An anaphylactic reaction to an NICM typically manifests as clinical symptoms that include an itchy nose, sneezing, and skin redness. To our knowledge, a rapid change in the caliber of the inferior vena cava (IVC) during multiphasic contrast-enhanced computed tomography (CT) has not been reported. Here, we report the computed tomographic findings in three cases of hypovolemic shock caused by an anaphylactic reaction to an NICM. We suspect that a decrease in caliber of the IVC during multiphasic contrast-enhanced CT may be a predictor of an allergic-like reaction to an NICM. Patients in whom physicians and radiographers detect a rapid caliber change in the IVC during multiphasic contrast-enhanced CT should be managed carefully.

    DOI： 10.1016/j.radcr.2018.07.002

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  • Association between reperfusion and shrinkage percentage of the aneurysmal sac after embolization of pulmonary arteriovenous malformation: evaluation based on contrast-enhanced thin-section CT images.

    Satoko Makimoto, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Toshihiro Iguchi, Yusuke Matsui, Hidefumi Mimura, Susumu Kanazawa

    Japanese journal of radiology   32 ( 5 )   266 - 73   2014年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    PURPOSE: To investigate an association between reperfusion and the percentage of shrinkage of the aneurysmal sac after embolization of pulmonary arteriovenous malformation (PAVM) and to determine the cutoff value of the shrinkage percentage for indicating reperfusion. MATERIALS AND METHODS: Twenty-two PAVMs with completely embolized feeding arteries with coils were examined. The percentage of sac shrinkage and the presence of reperfusion were evaluated on computed tomography before and 1, 3, and 12 months after embolization. The percentages of sac shrinkage were compared between the occlusion and reperfusion groups. The receiver-operating characteristic (ROC) curve was generated to determine the diagnostic efficiency of reperfusion of PAVM by using shrinkage percentages. RESULTS: Reperfusion was seen in 14, 13, and 11 lesions at 1, 3, and 12 months, respectively. The mean percentage of sac shrinkage was significantly different between the two groups at 3 and 12 months. The area under the ROC curve was 0.991 at 3 months and 0.934 at 12 months. All 9 lesions with <60% sac shrinkage at 12 months showed reperfusion. CONCLUSION: The percentage of sac shrinkage was closely associated with reperfusion after embolization of PAVMs at 3 and 12 months. A shrinkage percentage of <60% at 12 months indicated reperfusion.

    DOI： 10.1007/s11604-014-0301-5

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  • イレウスにて発症した心嚢内ヘルニアの1例

    槇本 怜子, 郷原 英夫, 櫻間 教文, 田邊 俊介, 野間 和広, 白川 靖博, 金澤 右

    臨床放射線   58 ( 12 )   1785 - 1788   2013年11月

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    記述言語：日本語   出版者・発行元：金原出版(株)  

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  • Lung cancer ablation: complications. 国際誌

    Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Hiroaki Ishii, Koji Tomita, Mayu Uka, Satoko Makimoto, Susumu Kanazawa

    Seminars in interventional radiology   30 ( 2 )   169 - 75   2013年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    Although radiofrequency ablation for lung cancer is generally safe (with a mortality rate <1%), it may cause various complications. Common complications include pneumothorax, pleural effusion, and parenchymal hemorrhage. Although most complications can be treated conservatively or with minimal therapy, physicians should be aware of rare but serious complications. Potentially fatal complications include massive hemorrhage, intractable pneumothorax due to bronchopleural fistula, pulmonary artery pseudoaneurysm, systemic air embolism, and pneumonitis. Other serious complications include injury to the nearby tissues (e.g., brachial nerve plexus, phrenic nerve, diaphragm, and chest wall), needle tract seeding, lung abscess, empyema, and skin burn. Although cavitation of the ablation zone is usually insignificant clinically, such a cavity occasionally ruptures, leading to pneumothorax and bleeding. Cavities may also serve as a scaffold for fungal colonization. Precautions to minimize risk should be taken whenever possible. Nevertheless, serious complications may occur, and thus physicians should be aware of the appropriate treatments for these complications. This article reviews complications associated with lung cancer ablation.

    DOI： 10.1055/s-0033-1342958

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▼全件表示

MISC

  • 原発不明癌の加療中に急速増大および特徴的画像所見を呈したスエヒロタケ感染の一例

    槇本 剛, 森 俊太, 藤井 裕生, 三鍋 博史, 槇本 怜子, 渡邉 哲, 冨樫 庸介

    日本呼吸器学会誌   15 ( 増刊 )   325 - 325   2026年3月

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    記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

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  • 造血幹細胞移植後の非感染性肺合併症を有する肺移植候補者における待機中死亡のリスク因子

    肥後 寿夫, 槇本 剛, 市原 英基, 槇本 怜子, 山本 治慎, 田中 真, 三好 健太郎, 杉本 誠一郎, 豊岡 伸一, 冨樫 庸介, 宮原 信明

    日本呼吸器学会誌   15 ( 増刊 )   164 - 164   2026年3月

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    記述言語：日本語   出版者・発行元：(一社)日本呼吸器学会  

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  • マルチユースCT用インジェクタの初期使用経験

    児島 克英, 北山 貴裕, 浅野 雄大, 大川 七子, 槇本 怜子, 檜垣 文代, 長野 晃, 森光 祐介, 赤木 憲明, 平木 隆夫

    Japanese Journal of Radiology   44 ( Suppl. )   56 - 56   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • Photon counting detector-CTによる脳動脈瘤血流改変ステント留置後の再構成関数の検討

    檜垣 文代, 長田 栞, 高橋 優花, 北山 貴裕, 浅野 雄大, 大川 七子, 槇本 怜子, 児島 克英, 春間 純, 平松 匡文, 井上 智洋, 森光 祐介, 平木 隆夫

    Japanese Journal of Radiology   44 ( Suppl. )   63 - 63   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 稀な膵神経鞘腫の1例

    太田 圭祐, 北山 貴裕, 浅野 雄大, 大川 七子, 槇本 怜子, 荻野 裕香, 檜垣 文代, 児島 克英, 高木 弘誠, 綾田 善行, 平木 隆夫

    Japanese Journal of Radiology   44 ( Suppl. )   68 - 68   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 臨床的にSweet症候群と診断した肺,頸部,脾病変を伴う1例

    太田 圭祐, 槇本 怜子, 北山 貴裕, 浅野 雄大, 大川 七子, 檜垣 文代, 児島 克英, 橋田 里妙, 松岡 賢市, 小野 早和子, 平木 隆夫

    Japanese Journal of Radiology   44 ( Suppl. )   57 - 57   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • IgG4関連冠動脈周囲炎の1例

    太田 圭祐, 大川 七子, 北山 貴裕, 浅野 雄大, 槇本 怜子, 檜垣 文代, 児島 克英, 宮脇 義亜, 三木 崇史, 綾田 善行, 平木 隆夫

    Japanese Journal of Radiology   44 ( Suppl. )   61 - 61   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 子宮頸部に発生した中腎癌の1例

    西原 千加, 浅野 雄大, 北山 貴裕, 槇本 怜子, 大川 七子, 檜垣 文代, 児島 克英, 平木 隆夫, 柳井 広之

    Japanese Journal of Radiology   44 ( Suppl. )   56 - 56   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 診断に苦慮した前立腺浸潤を来した膀胱癌の1例

    久保 遥祐, 浅野 雄大, 北山 貴裕, 大川 七子, 槇本 怜子, 荻野 裕香, 檜垣 文代, 児島 克英, 片山 聡, 柳井 広之, 平木 隆夫

    Japanese Journal of Radiology   44 ( Suppl. )   71 - 71   2026年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • タリウムシンチグラフィで特徴的な像を呈した下腿のメトトレキサート関連リンパ増殖性疾患の1例

    大森 真理, 北山 貴裕, 川田 まりあ, 浅野 雄大, 槇本 怜子, 檜垣 文代, 児島 克英, 大川 七子, 那須 義久, 小野 早和子, 柳井 広之, 平木 隆夫

    Japanese Journal of Radiology   43 ( Suppl. )   43 - 43   2025年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 10年以上の経過観察を得た中枢神経系血管芽腫の1例

    檜垣 文代, 川田 まりあ, 北山 貴裕, 浅野 雄大, 槇本 怜子, 児島 克英, 安原 隆雄, 大川 七子, 三橋 利晴, 平木 隆夫

    Japanese Journal of Radiology   43 ( Suppl. )   44 - 44   2025年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 先天性心膜欠損症の1例

    石城戸 輪也, 大川 七子, 川田 まりあ, 北山 貴裕, 浅野 雄大, 槇本 怜子, 檜垣 文代, 児島 克英, 黒子 洋介, 平木 隆夫

    Japanese Journal of Radiology   43 ( Suppl. )   40 - 40   2025年2月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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  • 顎下部腫瘤として発症した原発不明悪性黒色腫のリンパ節転移の一例

    久保 遥祐, 北山 貴裕, 浅野 雄大, 大川 七子, 槇本 怜子, 檜垣 文代, 児島 克英, 神野 泰輔, 森脇 悠利, 秋定 直樹, 小野 早和子, 大木 知佳, 平木 隆夫

    日本医学放射線学会秋季臨床大会抄録集   60回   S398 - S398   2024年9月

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    記述言語：日本語   出版者・発行元：(公社)日本医学放射線学会  

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