Faculty Profiles - SHIBATA Takashi

Papers - SHIBATA Takashi

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小林勝弘, 柴田敬, 土屋弘樹, 秋山倫之

臨床神経生理学 50 ( 5 ) 417 - 417 2022.10

A Case of a Solitary Cortical Tuber with No Other Manifestations of Tuberous Sclerosis Complex Mimicking Focal Cortical Dysplasia Type II with Calcification.

Kakeru Hosomoto, Tatsuya Sasaki, Koji Kawai, Yosuke Okazaki, Yuki Hyodo, Takashi Shibata, Susumu Sasada, Takao Yasuhara, Katsuhiro Kobayashi, Hiroyuki Yanai, Isao Date

Acta medica Okayama 76 ( 3 ) 323 - 328 2022.6

Language：English

Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case.

DOI： 10.18926/AMO/63742

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難治性てんかん患者におけるケトン食による代謝変化の網羅的検討

秋山麻里, 秋山倫之, 三枝大輔, 井上賢治, 森篤志, 最上友紀子, 藤井裕士, 所谷知穂, 桑原こずえ, 植松有里佳, 土屋弘樹, 柴田敬, 小林勝弘

脳と発達 54 ( Suppl. ) S222 - S222 2022.5

【脳波の読み方-up to date】疾患別の脳波睡眠時持続性棘徐波(CSWS)を示すてんかん性脳症およびLandau-Kleffner症候群 Invited

小林勝弘, 柴田敬, 土屋弘樹

Clinical Neuroscience 40 ( 4 ) 492 - 498 2022.4

Prolonged Video-EEG and Heart Rate Variability can Elucidate Autonomic Dysregulation in Infantile Apneic Seizures. Reviewed International journal

Shinsuke Maruyama, Puneet Jain, Kaajal Parbhoo, Cristina Go, Takashi Shibata, Hiroshi Otsubo

Pediatric neurology 127 48 - 55 2022.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Infantile apneic seizures (IASs) are unexpected life-threatening events. We aimed to determine the utility of prolonged video-electroencephalography (vEEG) and heart rate variability (HRV) in IAS. METHODS: The study included seven infants with apneic seizures captured by vEEG, percutaneous oxygen saturation (SpO2), and electrocardiography (ECG). Interictal, preictal, and postictal HRV of patients and N2 sleep HRV of 10 age-matched controls were determined. RESULTS: We analyzed seven vEEGs (duration = 17 to 87 hours) of seven patients aged three to 13 months (mean onset age of apneic event = 6.3 months). Fifteen apneic seizures (one to five per infant) were captured. The initial apneic seizure was captured at 7.5 to 76 hours (mean = 36.6 hours) after vEEG initiation. Ictal rhythmic delta/theta/fast waves were seen over temporal (five patients), central (one), and diffuse areas (one). Ictal SpO2 decreased between 1.5% and 90% (mean = 47.9%). Ictal decreased heart rate (HR) (six seizures) and ictal increased HR (14) was detected. Both decreased and increased HR was observed (five). The preictal low-frequency (LF)/high-frequency (HF) ratio was significantly higher than the interictal LF/HF ratio (P = 0.048). Preictal (P = 0.048), and postictal (P = 0.019) root mean square of successive differences (RMSSDs) of patients were lower than the sleep RMSSD of controls. These results indicated dominant sympathetic activity. RMSSD from interictal to preictal periods tended to be higher in IAS with decreased HR than in IAS with increased HR alone (P = 0.066). The postictal RMSSD showed tendency to be higher in IAS with decreased HR than in IAS with increased HR alone (P = 0.088). The decreased HR and increased RMSSD suggested not only sympathetic activity but also escalated parasympathetic activity in IAS. CONCLUSIONS: Infants with unexpected apneic events should be monitored with prolonged vEEG, SpO2, and ECG. Abnormal HRV in infants with apneic seizures might indicate additional autonomic dysregulation in IAS.

DOI： 10.1016/j.pediatrneurol.2021.11.007

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先天性心疾患の児に発症したてんかんの検討

柴田敬, 近藤麻衣子, 秋山麻里, 秋山倫之, 諸岡輝子, 馬場健児, 大月審一, 塚原宏一, 笠原真悟, 小林勝弘

日本小児科学会雑誌 126 ( 2 ) 303 - 303 2022.2

一酸化炭素中毒に対して高気圧酸素療法を施行した2例

浦田奈生子, 土屋弘樹, 柴田敬, 塚原紘平, 嶋泰樹, 小林勝弘

日本小児科学会雑誌 126 ( 2 ) 337 - 337 2022.2

一酸化炭素中毒に対して高気圧酸素療法を施行した2例

浦田奈生子, 土屋弘樹, 柴田敬, 塚原紘平, 嶋泰樹, 小林勝弘

脳と発達 53 ( 6 ) 469 - 469 2021.11

A study on the relationship between non-epileptic fast (40 – 200 Hz) oscillations in scalp EEG and development in children Reviewed International journal

Makio Oka, Katsuhiro Kobayashi, Takashi Shibata, Hiroki Tsuchiya, Yoshiyuki Hanaoka, Mari Akiyama, Teruko Morooka, Masao Matsuhashi, Tomoyuki Akiyama

Brain and Development 43 ( 9 ) 904 - 911 2021.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

OBJECTIVE: Physiological gamma and ripple activities may be linked to neurocognitive functions. This study investigated the relationship between development and non-epileptic, probably physiological, fast (40-200 Hz) oscillations (FOs) including gamma (40 - 80 Hz) and ripple (80 - 200 Hz) oscillations in scalp EEG in children with neurodevelopmental disorders. METHODS: Participants were 124 children with autism spectrum disorder (ASD) and/or attention deficit/hyperactivity disorder (ADHD). Gamma and ripple oscillations were explored from 60-second-long sleep EEG data in each subject using a semi-automatic detection tool supplemented with visual confirmation and time-frequency analysis. RESULTS: Gamma and ripple oscillations were detected in 25 (20.2%) and 22 (17.7%) children, respectively. The observation of one or more occurrence(s) of ripple oscillations, but not gamma oscillations, was significantly related to lower age at EEG recording (odds ratio, OR: 0.727 [95% confidence interval, CI: 0.568-0.929]), higher intelligence/developmental quotient (OR: 1.041, 95% CI: 1.002-1.082), and lack of a diagnosis with ADHD (OR: 0.191, 95% CI: 0.039 - 0.937) according to a binominal logistic regression analysis that included diagnosis with ASD, sex, history of perinatal complications, history of febrile seizures, and use of a sedative agent for the EEG recording as the other non-significant parameters. Diagnostic group was not related to frequency or power of spectral peaks of FOs. CONCLUSION: The production of non-epileptic scalp ripples was confirmed to be associated with brain development and function/dysfunction in childhood. Further investigation is necessary to interpret all of the information on higher brain functions that may be embedded in scalp FOs.

DOI： 10.1016/j.braindev.2021.05.004

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Exclusion of the Possibility of “False Ripples” From Ripple Band High-Frequency Oscillations Recorded From Scalp Electroencephalogram in Children With Epilepsy Reviewed International journal

Katsuhiro Kobayashi, Takashi Shibata, Hiroki Tsuchiya, Tomoyuki Akiyama

Frontiers in Human Neuroscience 15 696882 - 696882 2021.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

<sec><title>Aim</title>Ripple-band epileptic high-frequency oscillations (HFOs) can be recorded by scalp electroencephalography (EEG), and tend to be associated with epileptic spikes. However, there is a concern that the filtration of steep waveforms such as spikes may cause spurious oscillations or “false ripples.” We excluded such possibility from at least some ripples by EEG differentiation, which, in theory, enhances high-frequency signals and does not generate spurious oscillations or ringing.

</sec><sec><title>Methods</title>The subjects were 50 pediatric patients, and ten consecutive spikes during sleep were selected for each patient. Five hundred spike data segments were initially reviewed by two experienced electroencephalographers using consensus to identify the presence or absence of ripples in the ordinary filtered EEG and an associated spectral blob in time-frequency analysis (Session A). These EEG data were subjected to numerical differentiation (the second derivative was denoted as EEG″). The EEG″ trace of each spike data segment was shown to two other electroencephalographers who judged independently whether there were clear ripple oscillations or uncertain ripple oscillations or an absence of oscillations (Session B).

</sec><sec><title>Results</title>In Session A, ripples were identified in 57 spike data segments (Group A-R), but not in the other 443 data segments (Group A-N). In Session B, both reviewers identified clear ripples (strict criterion) in 11 spike data segments, all of which were in Group A-R (<italic>p</italic> &lt; 0.0001 by Fisher’s exact test). When the extended criterion that included clear and/or uncertain ripples was used in Session B, both reviewers identified 25 spike data segments that fulfilled the criterion: 24 of these were in Group A-R (<italic>p</italic> &lt; 0.0001).

</sec><sec><title>Discussion</title>We have demonstrated that real ripples over scalp spikes exist in a certain proportion of patients. Ripples that were visualized consistently using both ordinary filters and the EEG″ method should be true, but failure to clarify ripples using the EEG″ method does not mean that true ripples are absent.

</sec><sec><title>Conclusion</title>The numerical differentiation of EEG data provides convincing evidence that HFOs were detected in terms of the presence of such unusually fast oscillations over the scalp and the importance of this electrophysiological phenomenon.

</sec>

DOI： 10.3389/fnhum.2021.696882

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Rituximab Was Effective for Treatment of Anti–N-Methyl-d-Aspartate Receptor Encephalitis in Early Adolescence in Initially Suspected Dissociative Disorder Reviewed

Takashi Shibata, Hiroki Kawai, Shinji Sakamoto, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Manabu Takaki

Clinical Neuropharmacology 44 ( 3 ) 99 - 100 2021.5

Phase-amplitude coupling of interictal fast activities modulated by slow waves on scalp EEG and its correlation with seizure outcomes of disconnection surgery in children with intractable nonlesional epileptic spasms Reviewed International journal

Takehiro Uda, Ichiro Kuki, Takeshi Inoue, Noritsugu Kunihiro, Hiroharu Suzuki, Hiroshi Uda, Toshiyuki Kawashima, Kosuke Nakajo, Yoko Nakanishi, Shinsuke Maruyama, Takashi Shibata, Hiroshi Ogawa, Shin Okazaki, Hisashi Kawawaki, Kenji Ohata, Takeo Goto, Hiroshi Otsubo

Journal of Neurosurgery: Pediatrics 27 ( 5 ) 572 - 580 2021.5

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Neurosurgery Publishing Group (JNSPG)

<sec>
<title>OBJECTIVE</title>
Epileptic spasms (ESs) are classified as focal, generalized, or unknown onset ESs. The classification of ESs and surgery in patients without lesions apparent on MRI is challenging. Total corpus callosotomy (TCC) is a surgical option for diagnosis of the lateralization and possible treatment for ESs. This study investigated phase-amplitude coupling (PAC) of fast activity modulated by slow waves on scalp electroencephalography (EEG) to evaluate the strength of the modulation index (MI) before and after disconnection surgery in children with intractable nonlesional ESs. The authors hypothesize that a decreased MI due to surgery correlates with good seizure outcomes.

</sec>
<sec>
<title>METHODS</title>
The authors studied 10 children with ESs without lesions on MRI who underwent disconnection surgeries. Scalp EEG was obtained before and after surgery. The authors collected 20 epochs of 3 minutes each during non–rapid eye movement sleep. The MI of the gamma (30–70 Hz) amplitude and delta (0.5–4 Hz) phase was obtained in each electrode. MIs for each electrode were averaged in 4 brain areas (left/right, anterior/posterior quadrants) and evaluated to determine the correlation with seizure outcomes.

</sec>
<sec>
<title>RESULTS</title>
The median age at first surgery was 2.3 years (range 10 months–9.1 years). Two patients with focal onset ESs underwent anterior quadrant disconnection (AQD). TCC alone was performed in 5 patients with generalized or unknown onset ESs. Two patients achieved seizure freedom. Three patients had residual generalized onset ESs. Disconnection surgeries in addition to TCC consisted of TCC + posterior quadrant disconnection (PQD) (1 patient); TCC + AQD + PQD (1 patient); and TCC + AQD + hemispherotomy (1 patient). Seven patients became seizure free with a mean follow-up period of 28 months (range 5–54 months). After TCC, MIs in 4 quadrants were significantly lower in the 2 seizure-free patients than in the 6 patients with residual ESs (p < 0.001). After all 15 disconnection surgeries in 10 patients, MIs in the 13 target quadrants for each disconnection surgery that resulted in freedom from seizures were significantly lower than in the 26 target quadrants in patients with residual ESs (p < 0.001).

</sec>
<sec>
<title>CONCLUSIONS</title>
In children with nonlesional ESs, PAC for scalp EEG before and after disconnection surgery may be a surrogate marker for control of ESs. The MI may indicate epileptogenic neuronal modulation of the interhemispheric corpus callosum and intrahemispheric subcortical network for ESs. TCC may be a therapeutic option to disconnect the interhemispheric modulation of epileptic networks.

</sec>

DOI： 10.3171/2020.9.peds20520

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Other Link： https://thejns.org/downloadpdf/journals/j-neurosurg-pediatr/27/5/article-p572.xml

小児神経疾患患者における尿中メタボローム解析の経験

秋山倫之, 久原とみ子, 大瀬守眞, 秋山麻里, 柴田敬, 花岡義行, 土屋弘樹, 兵頭勇紀, 小林勝弘

脳と発達 53 ( Suppl. ) S240 - S240 2021.5

小児神経疾患患者における尿中メタボローム解析の経験

秋山倫之, 久原とみ子, 大瀬守眞, 秋山麻里, 柴田敬, 花岡義行, 土屋弘樹, 兵頭勇紀, 小林勝弘

脳と発達 53 ( Suppl. ) S240 - S240 2021.5

Phase-amplitude coupling of delta brush unveiling neuronal modulation development in the neonatal brain Reviewed

Takashi Shibata, Hiroshi Otsubo

Neuroscience Letters 735 135211 - 135211 2020.9

Autonomic dysregulation in children with epilepsy with postictal generalized EEG suppression following generalized convulsive seizures Reviewed

Kazuo Okanari, Shinsuke Maruyama, Hiroharu Suzuki, Takashi Shibata, Elizabeth Pulcine, Elizabeth J. Donner, Hiroshi Otsubo

Epilepsy & Behavior 102 106688 - 106688 2020.1

Novel AVPR2 variant in a male infant with nephrogenic diabetes insipidus who showed delayed head control Reviewed

Kosei Hasegawa, Hiromi Ihoriya, Natsuko Futagawa, Yousuke Higuchi, Hiroki Tsuchiya, Takashi Shibata, Yumiko Hayashi, Katsuhiro Kobayashi, Hirokazu Tsukahara

Clinical Pediatric Endocrinology 28 ( 4 ) 155 - 158 2019.10

Anti-NMDA-receptor antibody in initial diagnosis of mood disorder Reviewed

Hiroki Kawai, Manabu Takaki, Shinji Sakamoto, Takashi Shibata, Ayaka Tsuchida, Bunta Yoshimura, Yuji Yada, Namiko Matsumoto, Kota Sato, Koji Abe, Yuko Okahisa, Yoshiki Kishi, Soshi Takao, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Norihito Yamada

European Neuropsychopharmacology 29 ( 9 ) 1041 - 1050 2019.9

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier BV

Anti-NMDAR encephalitis is increasingly recognized as one etiology of psychiatric symptoms, but there is not enough evidence on patients with mood disorder. We assayed anti-NR1/NR2B IgG antibodies in serum and/or cerebrospinal fluid of 62 patients initially diagnosed with mood disorder by a cell-based assay. We also investigated the specific patient characteristics and psychotic symptoms. At first admission, the patients showed only psychiatric symptoms without typical neurological signs or abnormal examination findings. Four of the 62 patients had anti-NR1/NR2B IgG antibodies. The anti-NR1/NR2B IgG antibody-positive patients showed more super- or abnormal sensitivity (P = 0.00088), catatonia (P = 0.049), and more conceptual disorganization (P < 0.0001), hostility (P = 0.0010), suspiciousness (P < 0.0001), and less emotional withdrawal (P < 0.0001) and motor retardation (P < 0.0001) on the Brief Psychiatric Rating Scale than the antibody-negative patients. During the clinical course, anti-NR1/NR2B IgG antibody-positive patients showed more catatonia (P = 0.0042) and met Graus's criteria for diagnosis of anti-NMDAR encephalitis, but negative patients did not. Immunotherapy was effective for anti-NR1/NR2B IgG antibody-positive patients, and there was the weak relationship (R² = 0.318) between the anti-NR1/NR2B IgG antibody titer in the cerebrospinal fluid and the Brief Psychiatric Rating Scale score.

DOI： 10.1016/j.euroneuro.2019.07.137

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Infantile spasmsにおける初回ACTH療法後の再発に関する検討

金聖泰, 小林勝弘, 兵頭勇紀, 藤代定志, 水野むつみ, 道上理絵, 宮原大輔, 花岡義行, 柴田敬, 秋山麻里, 岡牧郎, 遠藤文香, 秋山倫之

てんかん研究 37 ( 2 ) 574 - 574 2019.9

West症候群を発症した結節性硬化症症例のてんかんの経過と幼児期早期の発達について

遠藤文香, 土屋弘樹, 兵頭勇紀, 水野むつみ, 金聖泰, 花岡義行, 柴田敬, 秋山麻里, 小林勝弘

脳と発達 51 ( Suppl. ) S279 - S279 2019.5

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