研究者詳細 - 宮原　信明

論文 - 宮原　信明

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[Case of pulmonary Langerhans-cell histiocytosis]. 査読

Sakugawa M, Tanimoto Y, Miyahara N, Kanehiro A, Kataoka M, Tanimoto M, Date H, Shimizu N, Yamadori I, Shibayama T

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 91 ( 9 ) 2765 - 2767 2002年9月

記述言語：日本語出版者・発行元：The Japanese Society of Internal Medicine

症例は19歳,男性. 17歳時より1日20本の喫煙歴あり.検診にて胸部異常陰影を指摘され,胸部CTでは両側上肺野に多発性嚢胞性病変を認めた.気管支肺胞洗浄液(BALF)の塗抹標本にてCDla陽性細胞およびS-100陽性細胞の増加を認め,胸腔鏡下肺生検により肺Langerhans細胞性組織球症(肺LCH)の診断が得られた.肺LCHは喫煙の関与が指摘されている稀な疾患であり,文献的考察を加えて報告する.

DOI： 10.2169/naika.91.2765

その他リンク： https://jlc.jst.go.jp/DN/JALC/00159941087?from=CiNii

[Orchiectomy for tuberculous epididymitis: a report of two cases with intractable to antituberculosis treatment].

N Kunichika, K Murakami, K Makihata, K Takao, K Chikamori, K Aoe, N Miyahara, T Maeda, R Eda, H Takeyama

Kekkaku : [Tuberculosis] 76 ( 10 ) 673 - 6 2001年10月

記述言語：日本語掲載種別：研究論文（学術雑誌）

This paper describes two cases with tuberculous epididymitis. The first case was a 69-year-old man who was admitted to our hospital because of ulceration or right scrotum. Physical examination revealed a hard, rounded, a little bigger than egg-sized mass in the right scrotum. The second case was a 40-year-old man who was admitted to our hospital because of cough, fever and body weight loss. He was treated for pulmonary tuberculosis with isoniazid, rifampicin, streptomycin and pyrazinamide. Six months after admission, he complained of a painless swelling of the right scrotum. Physical examination revealed a hard, rounded, more than egg-sized mass in the right scrotum. Right orchiectomy was performed in these two cases, and they were cured.

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Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis 査読

N Miyahara, R Eda, Y Umemori, T Murakami, N Kunichika, K Makihata, K Aoe, K Murakami, H Takeyama, M Harada

INTERNAL MEDICINE 40 ( 8 ) 786 - 790 2001年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.

Web of Science

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Compound heterozygosity for alpha-1-antitrypsin (S(iiyama) and QO(clayton)) in an Oriental patient.

N Miyahara, K Seyama, T Sato, Y Fukuchi, R Eda, H Takeyama, M Harada

Internal medicine (Tokyo, Japan) 40 ( 4 ) 336 - 40 2001年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Alpha-1-antitrypsin (alpha1AT) deficiency is extremely rare among Orientals. We treated a 37-year-old man with severe pulmonary emphysema associated with a low serum concentration of alpha1AT. Mutation analysis of the alpha1AT gene was performed using a reverse transcription-polymerase chain reaction followed by sequencing. The patient proved to be a compound heterozygote carrying a S(iiyama) deficient allele and a QO(clayton) null allele. This is the first Japanese case of alpha1AT deficiency to arise from such compound heterozygosity in a family with no apparent consanguineous marriage, suggesting that the gene frequency for deficient alleles might be somewhat higher than previously estimated.

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Effects of short-term pulmonary rehabilitation on exercise capacity and quality of life in patients with chronic obstructive pulmonary disease.

N Miyahara, R Eda, H Takeyama, N Kunichika, M Moriyama, K Aoe, H Kohara, K Chikamori, T Maeda, M Harada

Acta medica Okayama 54 ( 4 ) 179 - 84 2000年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Although the rehabilitation of patients with chronic obstructive pulmonary disease (COPD) improves both exercise capacity and quality of life, a standard protocol for COPD patients has not been established. To clarify whether physiologic and quality-of-life improvements can be achieved by an inpatient pulmonary rehabilitation program 5 days per week for 3 weeks, 18 patients with COPD were enrolled in a rehabilitation program. The physical exercise training regimen consisted of respiratory muscle stretch gymnastics and cycle ergometer exercise training. Pulmonary function tests, an incremental ergometer exercise test, a 6-min walking test, and a quality of life assessment by the Chronic Respiratory Questionnaire were administered before and after the program. The peak VO2, an indicator of maximal exercise capacity, did not increase, although the 6-min walking distance, an indicator of functional exercise capacity, increased significantly after rehabilitation. There was a significant improvement in the quality of life in terms of dyspnea, fatigue, and emotional state. These findings suggest that even a 3-week program may be beneficial for COPD patients. Increases in functional exercise capacity, even without an increase in maximal exercise capacity, are helpful for reducing dyspnea and improving quality of life parameters in patients with COPD.

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Cardiorespiratory responses during cycle ergometer exercise with different ramp slope increments in patients with chronic obstructive pulmonary disease.

N Miyahara, R Eda, H Takeyama, T Maeda, K Aoe, N Kunichika, H Kohara, M Harada

Internal medicine (Tokyo, Japan) 39 ( 1 ) 15 - 9 2000年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: The ramp exercise test has been widely used to evaluate cardiopulmonary responses to an incremental exercise load. This study was performed to clarify whether different slopes of the ramp exercise test influence exercise tolerance, exercise limiting factors, and respiratory pattern in patients with chronic obstructive pulmonary disease (COPD). SUBJECTS AND METHODS: We applied three different slopes (5 W/min, 10 W/min and 20 W/min) of the ramp exercise test in 9 patients with COPD and evaluated cardiopulmonary responses. RESULTS: There were no significant differences in peak oxygen uptake, anaerobic threshold (AT), minute ventilation, heart rate, arterial oxygen saturation, expired tidal volume, or respiratory rate at the maximal load among the three different ramp exercises tested. AT could be determined in six of nine patients (67%) at the slope of 5 W/min, in 8/9 (89%) at the slope of 10 W/min, and in 9/9 (100%) at the slope of 20 W/min. CONCLUSION: The findings suggest that the ramp slope does not affect exercise tolerance, exercise limiting factors, or respiratory patterns and each of these ramp slopes is useful for the evaluation of COPD. Ramp slopes of 10 W/ min or 20 W/min should be appropriate for the determination of AT.

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1. 高齢者誤嚥性肺炎によるARDSの1例(一般演題)(第8回日本気管支学会中国四国支部会)

巻幡清, 江田良輔, 宮原信明, 森山道彦, 日山篤人, 村上一生, 近森研一, 小原弘之, 国近尚美, 青江啓介, 前田忠士, 竹山博泰, 内田亨, 遠藤定紀

気管支学 22 ( 4 ) 306 - 306 2000年

16. Rifampicinによる薬剤性肺炎の1例(一般演題)(第8回日本気管支学会中国四国支部会)

國近尚美, 宮原信明, 江田良輔, 森山道彦, 巻幡清, 近森研一, 小原弘之, 青江啓介, 前田忠士, 竹山博泰

気管支学 22 ( 4 ) 308 - 308 2000年

Bronchial atresia with transient spontaneous disappearance of a mucocele.

N Miyahara, R Eda, S Makihara, T Maeda, K Aoe, N Kunichika, H Kohara, H Takeyama, M Harada

Internal medicine (Tokyo, Japan) 38 ( 12 ) 974 - 8 1999年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

We report the transient spontaneous disappearance of a mucocele due to bronchial atresia. Two years before presentation, a chest radiograph showed a hyperlucent right upper lung and a mucocele near the right hilum. A chest radiograph taken 1 year later showed that the mucocele had disappeared leaving an ovoid outline of a dilated bronchus. A chest radiograph obtained 3 months before presentation showed that the mucocele was present again. Atresia of the B3b bronchus of the right upper lobe was noted on thoracotomy. The "disappearance" of the mucocele probably was due to the clearance of mucoid material through collateral airways.

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39. Isoniazid によると考えられた薬剤性間質性肺炎の 1 例(第 7 回日本気管支学会中国四国支部会)

石川優子, 宮原信明, 江田良輔, 國近尚美, 青江啓介, 森山道彦, 近森研一, 前田忠士, 河村武郎, 竹山博泰

気管支学 21 ( 2 ) 128 - 128 1999年