Faculty Profiles - TANABE Shunsuke

Papers - TANABE Shunsuke

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尾山貴徳, 野田卓男, 谷守通, 納所洋, 谷本光隆, 野間和広, 田邊俊介, 白川靖博, 藤原俊義

日本小児外科学会雑誌 52 ( 7 ) 1376 - 1376 2016.12

腹腔鏡下胃癌手術における脾門部郭清アプローチ脾門部の解剖に基づく腹腔鏡下脾温存リンパ節郭清

西崎正彦, 黒田新士, 菊地覚次, 伊藤雅典, 田邊俊介, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本臨床外科学会雑誌 77 ( 増刊 ) 446 - 446 2016.10

Double-Flap Technique as an Antireflux Procedure in Esophagogastrostomy after Proximal Gastrectomy. Reviewed International journal

Shinji Kuroda, Masahiko Nishizaki, Satoru Kikuchi, Kazuhiro Noma, Shunsuke Tanabe, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

Journal of the American College of Surgeons 223 ( 2 ) e7-e13 2016.8

食道癌患者の口腔感染管理と咬合回復が周術期の体重変化に影響した可能性のある一症例

樋口智子, 花岡愛弓, 山中玲子, 仲田直樹, 曽我賢彦, 飯田征二, 田邊俊介, 野間和広, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 70回 193 - 193 2016.7

Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer. Reviewed International journal

Michihiro Ishida, Shunsuke Kagawa, Kyoko Shimoyama, Kiyoto Takehara, Kazuhiro Noma, Shunsuke Tanabe, Yasuhiro Shirakawa, Hiroshi Tazawa, Hisataka Kobayashi, Toshiyoshi Fujiwara

Molecular cancer therapeutics 15 ( 3 ) 402 - 11 2016.3

Language：English Publishing type：Research paper (scientific journal)

Peritoneal dissemination is the most frequent metastasis in gastric cancer and is associated with poor prognosis. The lack of particular target antigens in gastric cancer other than HER2 has hampered the development of treatments for peritoneal dissemination of gastric cancer. We hypothesized that HER2-extracellular domain (HER2-ECD) gene transduction combined with trastuzumab-based photoimmunotherapy (PIT) might provide excellent and selective antitumor effects for peritoneal dissemination of gastric cancer. In vitro, adenovirus/HER2-ECD (Ad/HER2-ECD) efficiently transduced HER2-ECD into HER2-negative gastric cancer cells. Trastuzumab-IR700 (Tra-IR700)-mediated PIT induced selective cell death of HER2-ECD-transduced tumor cells. Ad/HER2-ECD also induced homogenous expression of HER2 in heterogeneous gastric cancer cells, resulting in uniform sensitivity of the cells to Tra-IR700-mediated PIT. Anti-HER2 PIT integrated with adenoviral HER2-ECD gene transfer was applied in mice bearing peritoneal dissemination of HER2-negative gastric cancer. Intraperitoneal administration of Ad/HER2-ECD and Tra-IR700 with PIT inhibited peritoneal metastasis and prolonged the survival of mice bearing MKN45. Furthermore, minimal side effects allowed the integrated therapy to be used repeatedly, providing better control of peritoneal dissemination. In conclusion, the novel therapy of molecular-targeted PIT integrated with gene transfer technology is a promising approach for the treatment of peritoneal dissemination in gastric cancer.

DOI： 10.1158/1535-7163.MCT-15-0644

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Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma. Reviewed International journal

Yukiko Yasuda, Akiko Sakai, Sachio Ito, Yuichiro Mita, Takayuki Sonoyama, Shunsuke Tanabe, Yasuhiro Shirakawa, Yoshio Naomoto, Hiroshi Katayama, Kenji Shimizu

International journal of molecular epidemiology and genetics 7 ( 1 ) 58 - 66 2016

Language：English Publishing type：Research paper (scientific journal)

Human RAD17, a human homolog of the Schizosaccharomyces pombe cell cycle checkpoint gene RAD17, plays a significant role in activating checkpoint signals in response to DNA damage. We evaluated the association of hRAD17 Leu546Arg (rs1045051), a missense single nucleotide polymorphism, with the risk of esophageal squamous cell carcinoma in relation to smoking and alcohol consumption history in 154 esophageal squamous cell carcinoma male patients and 695 cancer-free male controls by a case-control study conducted in Japan. The results showed that the hRAD17 Arg/Arg genotype compared to the Leu/Leu and Leu/Arg genotypes was significantly associated with the risk of the esophageal squamous cell carcinoma with an adjusted odds ratios of 2.22 (95% CI: 1.19-4.16 P=0.013). In stratified studies, the risk of esophageal squamous cell carcinoma was markedly higher in light drinkers (less than 23 g ethanol/day) with the Arg/Arg genotype than in heavy drinkers (excess of 23 g ethanol/day) with the Arg/Arg genotype (OR=2.83, 95% CI: 1.05-7.61, P=0.04). We concluded that the genetic variant of hRAD17 Leu546Arg polymorphism exerts a significant effect on esophageal squamous cell carcinoma risk among Japanese men.

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腹腔鏡下噴門側胃切除後の再建ベストな再建方法はどれか逆流防止弁形成食道残胃吻合(観音開き法)

西崎正彦, 黒田新士, 菊地覚次, 田邊俊介, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本内視鏡外科学会雑誌 20 ( 7 ) DS12 - 1 2015.12

胃疾患に対する内視鏡外科手術手技腹腔鏡下噴門側胃切除術におけるリンパ節郭清手技の定型化

西崎正彦, 黒田新士, 菊地覚次, 坂本修一, 田邊俊介, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本臨床外科学会雑誌 76 ( 増刊 ) 389 - 389 2015.10

新規免疫療法と化学療法食道癌に対する放射線療法との併用におけるテロメラーゼ標的腫瘍溶解性ウイルス、OBP-301の内視鏡的腫瘍内投与の第1/2相研究(Novel Immunotherapy and Chemothnorty A phase I/II study of endoscopic intratumoral administration of a telomerase targeted oncolytic virus, OBP-301, in combination with radiotherapy for esophageal cancer)

Kagawa Shunsuke, Tanabe Shunsuke, Tazawa Hiroshi, Noma Kazuhiro, Koujima Takeshi, Kashima Hajime, Kato Takuya, Kuroda Shinji, Kikuchi Satoru, Shirakawa Yasuhiro, Fujiwara Toshiyoshi

日本癌治療学会誌 50 ( 3 ) 1116 - 1116 2015.9

食道癌に対する放射線併用ウイルス療法の臨床研究レベル1投与量群の中間報告

田邊俊介, 白川靖博, 加藤卓也, 竹原清人, 前田直見, 黒田新士, 野間和広, 田澤大, 香川俊輔, 藤原俊義

日本消化器外科学会総会 70回 O - 6 2015.7

内視鏡腹腔鏡併用手術治療の工夫 Closed LECS手術手技のコツとピットフォール

西崎正彦, 黒田新士, 加藤大, 菊地覚次, 香川哲也, 田邊俊介, 香川俊輔, 白川靖博, 岡田裕之, 藤原俊義

日本消化器外科学会総会 70回 RS - 5 2015.7

噴門側胃切除術後の再建空腸間置vs食道胃吻合上部消化管食道胃吻合

西崎正彦, 黒田新士, 野間和広, 菊地覚次, 桑田和也, 前田直見, 田邊俊介, 香川俊輔, 白川靖博, 藤原俊義

日本外科学会定期学術集会抄録集 115回 DB - 2 2015.4

上部消化管胃癌に対する腹膜洗浄術についての蛍光発現ウイルスTelomescanによる新規細胞学的診断(Novel cytological diagnosis of peritoneal wash for gastric cancer by fluorescence-emitting virus TelomeScan)

香川俊輔, 渡邉めぐみ, 石田道拡, 黒田新士, 菊地覚次, 田澤大, 岸本浩行, 桑田和也, 久保田哲史, 堀直人, 田邊俊介, 西崎正彦, 浦田泰生, 藤原俊義

日本外科学会定期学術集会抄録集 115回 IS - 6 2015.4

上部消化管 HER2陰性癌細胞に対するHER2細胞外ドメインによる非機能性HER2抗原遺伝子修飾とTrastuzumabを用いた分子標的光免疫療法を併用した治療戦略

石田道拡, 香川俊輔, 下山京子, 竹原清人, 渡邉めぐみ, 菊地覚次, 黒田新士, 野間和広, 岸本浩行, 田澤大, 田邊俊介, 小林久隆, 藤原俊義

日本外科学会定期学術集会抄録集 115回 OP - 3 2015.4

非機能性HER2抗原で遺伝子修飾したHER2陰性癌細胞に対する分子標的光免疫療法

石田道拡, 香川俊輔, 下山京子, 竹原清人, 渡邉めぐみ, 菊地覚次, 黒田新士, 野間和広, 岸本浩行, 西崎正彦, 田澤大, 田邊俊介, 小林久隆, 藤原俊義

日本胃癌学会総会記事 87回 402 - 402 2015.3

Prone-position thoracoscopic resection of posterior mediastinal lymph node metastasis from rectal cancer. Reviewed International journal

Yasuhiro Shirakawa, Kazuhiro Noma, Takeshi Koujima, Naoaki Maeda, Shunsuke Tanabe, Toshiaki Ohara, Toshiyoshi Fujiwara

World journal of surgical oncology 13 45 - 45 2015.2

Language：English Publishing type：Research paper (scientific journal)

Mediastinal lymph node metastasis from colorectal cancer is rare, and barely any reports have described resection of this pathology. We report herein a successful thoracoscopic resection of mediastinal lymph node metastasis in a prone position. A 65-year-old man presented with posterior mediastinal lymph node metastasis after resection of the primary rectal cancer and metachronous hepatic metastasis. Metastatic lymph nodes were resected completely using thoracoscopic surgery in the prone position, which provided advantages of minimal invasiveness, good surgical field, and reduced ergonomic burden on the surgeon. Thoracoscopic resection in the prone position was thought to have the potential to become the standard procedure of posterior mediastinal tumors.

DOI： 10.1186/s12957-015-0466-0

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Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2-negative breast cancer cells. Reviewed International journal

Kyoko Shimoyama, Shunsuke Kagawa, Michihiro Ishida, Shinichiro Watanabe, Kazuhiro Noma, Kiyoto Takehara, Hiroshi Tazawa, Yuuri Hashimoto, Shunsuke Tanabe, Junji Matsuoka, Hisataka Kobayashi, Toshiyoshi Fujiwara

Breast cancer research and treatment 149 ( 3 ) 597 - 605 2015.2

Language：English Publishing type：Research paper (scientific journal)

The prognosis of HER2-positive breast cancer has been improved by trastuzumab therapy, which features high specificity and limited side effects. However, trastuzumab-based therapy has shortcomings. Firstly, HER2-targeted therapy is only applicable to HER2-expressing tumors, which comprise only 20-25% of primary breast cancers. Secondly, many patients who initially respond to trastuzumab ultimately develop disease progression. To overcome these problems, we employed virus-mediated HER2 transduction and photoimmunotherapy (PIT) which involves trastuzumab conjugated with a photosensitizer, trastuzumab-IR700, and irradiation of near-infrared light. We hypothesized that the gene transduction technique together with PIT would expand the range of tumor entities suitable for trastuzumab-based therapy and improve its antitumor activity. The HER2-extracellular domain (ECD) was transduced by the adenoviral vector, Ad-HER2-ECD, and PIT with trastuzumab-IR700 was applied in the HER2-negative cancer cells. Ad-HER2-ECD can efficiently transduce HER2-ECD into HER2-negative human cancer cells. PIT with trastuzumab-IR700 induced direct cell membrane destruction of Ad-HER2-ECD-transduced HER2-negative cancer cells. Novel combination of viral transduction of a target antigen and an antibody-based PIT would expand and potentiate molecular-targeted therapy even for target-negative or attenuated cancer cells.

DOI： 10.1007/s10549-015-3265-y

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Prone-Position Thoracoscopic Ligation of the Thoracic Duct for Chyle Leak Following Radical Neck Dissection in a Patient with a Right Aortic Arch. Reviewed

Yasuhiro Shirakawa, Kazuhiro Noma, Toshiaki Ohara, Hajime Kashima, Naoaki Maeda, Shunsuke Tanabe, Shunsuke Kagawa, Toshiyoshi Fujiwara

Acta medica Okayama 69 ( 3 ) 173 - 6 2015

Language：English Publishing type：Research paper (scientific journal)

A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edward's classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position.

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小児先天性食道狭窄症に対する下部食道・噴門側胃切除後漿膜筋層フラップによる噴門形成術(観音開き法)

野田卓男, 尾山貴徳, 谷本光隆, 野間和広, 田邊俊介, 白川靖博, 藤原俊義

日本臨床外科学会雑誌 75 ( 増刊 ) 458 - 458 2014.10

HER2抗原で修飾された癌細胞に対するTrastuzumabを用いた近赤外線光線免疫療法の効果(Genetic decoration with HER2-antigen makes cancer cells vulnerable to trastuzumab-based photoimmunotherapy)

石田道拡, 香川俊輔, 下山京子, 竹原清人, 野間和広, 田澤大, 黒田新士, 岸本浩行, 田邊俊介, 小林久隆, 藤原俊義

日本癌学会総会記事 73回 E - 3040 2014.9

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Papers - TANABE Shunsuke