研究者詳細 - 春間　純

論文 - 春間　純

分割表示 182 件中 121 - 140 件目／全件表示 >>

頭蓋内血管病変に対する3次元回転画像を用いたfusion imageの活用法

平松匡文, 杉生憲志, 菱川朋人, 春間純, 清水智久, 高杉祐二, 西廣真吾, 新治有径, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 308 - 308 2014年12月

未破裂脳動脈瘤コイル塞栓術におけるVerifyNow使用の有用性

新治有径, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 清水智久, 高杉祐二, 西廣真吾, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 252 - 252 2014年12月

当院におけるStaged carotid artery stenting(Staged-CAS)の検討

春間純, 杉生憲志, 菱川朋人, 平松匡文, 清水智久, 高杉祐二, 新治有径, 西廣真吾, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 218 - 218 2014年12月

前交通動脈瘤に対するコイル塞栓術の治療成績

西廣真吾, 杉生憲志, 菱川朋人, 新治有径, 高杉祐二, 清水智久, 春間純, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 272 - 272 2014年12月

脳動脈瘤コイル塞栓術後の再発評価における頭部単純X線検査の有用性

冨田祐介, 杉生憲志, 菱川朋人, 西廣真吾, 新治有径, 高杉祐二, 清水智久, 春間純, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 264 - 264 2014年12月

内頸動脈前脈絡叢動脈分岐部動脈瘤に対するコイル塞栓術の治療成績

西廣真吾, 杉生憲志, 菱川朋人, 新治有径, 高杉祐二, 清水智久, 春間純, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 273 - 273 2014年12月

内頸動脈-上下垂体動脈瘤(IC-SHA動脈瘤)に対する血管内治療 100例の検討

春間純, 杉生憲志, 菱川朋人, 西廣真吾, 新治有径, 高杉祐二, 清水智久, 平松匡文, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 272 - 272 2014年12月

コイル塞栓術後再発脳動脈瘤に対するコイル塞栓術の治療成績

菱川朋人, 杉生憲志, 平松匡文, 春間純, 清水智久, 高杉祐二, 新治有径, 西廣真吾, 徳永浩司, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 206 - 206 2014年12月

バルーン閉塞試験その判定方法とバイパス術の適応内頸動脈閉塞試験(balloon test occlusion:BTO)における合併症と妥当性の検討

清水智久, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 冨田祐介, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 184 - 184 2014年12月

大型・巨大脳動脈瘤に対するコイル塞栓術の治療成績

高杉祐二, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 清水智久, 新治有径, 西廣真吾, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 210 - 210 2014年12月

椎骨動脈解離性動脈瘤に対する血管内治療(internal trapping)後の延髄梗塞は高率に発生するのか?

清水智久, 杉生憲志, 菱川朋人, 平松匡文, 春間純, 高杉祐二, 新治有径, 西廣真吾, 冨田祐介, 伊達勲

JNET: Journal of Neuroendovascular Therapy 8 ( 6 ) 210 - 210 2014年12月

ラット慢性脳虚血モデルに対する血行再建術におけるVEGFおよびapelin遺伝子の血管新生効果についての検討

平松匡文, 杉生憲志, 菱川朋人, 西廣真吾, 春間純, 清水智久, 高杉祐二, 新治有径, 伊達勲, 徳永浩司, 木戸屋浩康, 高倉伸幸

脳循環代謝 26 ( 1 ) 225 - 225 2014年11月

再灌流障害と急性期血管内治療急性期脳梗塞に対する血管内再開通療法の現状

杉生憲志, 菱川朋人, 平松匡文, 春間純, 清水智久, 高杉祐二, 西廣真吾, 新治有径, 伊達勲

脳循環代謝 26 ( 1 ) 118 - 118 2014年11月

ラットくも膜下出血後脳血管攣縮に対する抗HMGB-1抗体の攣縮抑制効果の検討

春間純, 菱川朋人, 劉克約, 西廣真吾, 新治有径, 高杉佑二, 清水智久, 平松匡文, 杉生憲志, 西堀正洋, 伊達勲

脳循環代謝 26 ( 1 ) 178 - 178 2014年11月

ADH蛍光によるラットくも膜下出血急性期におけるspreading depressionの可視化及びその組織学的検討

清水智久, 菱川朋人, 高杉祐二, 新治有径, 西廣真吾, 春間純, 平松匡文, 杉生憲志, 武田吉正, 森松博史, 伊達勲

脳循環代謝 26 ( 1 ) 183 - 183 2014年11月

Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction. 国際誌

Yu Okuma, Keyue Liu, Hidenori Wake, Rui Liu, Yoshito Nishimura, Zhong Hui, Kiyoshi Teshigawara, Jun Haruma, Yasuhiko Yamamoto, Hiroshi Yamamoto, Isao Date, Hideo K Takahashi, Shuji Mori, Masahiro Nishibori

Neuropharmacology 85 18 - 26 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

Glycyrrhizin (GL) is a major constituent of licorice root and has been suggested to inhibit the release of high mobility group box-1 (HMGB1), a protein considered representative of damage-associated molecular patterns. We found that GL bound HMGB1 but not RAGE with a moderate equilibrium dissociation constant value based on surface plasmon resonance analysis. This complex formation prevented HMGB1 from binding to RAGE in vitro. The effects of glycyrrhizin on traumatic brain injury (TBI) induced by fluid percussion were examined in rats or mice in the present study. GL was administered intravenously after TBI. Treatment of rats with GL dose-dependently suppressed the increase in BBB permeability and impairment of motor functions, in association with the inhibition of HMGB1 translocation in neurons in injured sites. The beneficial effects of GL on motor and cognitive functions persisted for 7 days after injury. The expression of TNF-α, IL-1β and IL-6 in injured sites was completely inhibited by GL treatment. In RAGE-/- mice, the effects of GL were not observed. These results suggested that GL may be a novel therapeutic agent for TBI through its interference with HMGB1 and RAGE interaction.

DOI： 10.1016/j.neuropharm.2014.05.007

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Nationwide survey of the nature and risk factors of complications in embolization of meningiomas and other intracranial tumors: Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2). 国際誌

Tomohito Hishikawa, Kenji Sugiu, Masafumi Hiramatsu, Jun Haruma, Koji Tokunaga, Isao Date, Nobuyuki Sakai

Neuroradiology 56 ( 2 ) 139 - 44 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Embolization of intracranial tumor is widely performed in Japan, mainly before neurosurgical resection. A retrospective, multicenter, observational study in Japan was conducted to clarify the nature, frequency, and risk factors of complications in intracranial tumor embolization. METHODS: Patients were derived from the Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2). A total of 20,854 patients were enrolled in JR-NET2, of which 1,018 patients (4.88 %) with intracranial tumors underwent embolization. The primary end point was the proportion of patients with a modified Rankin scale (mRS) score of 0-2 (independency) at 30 days. The secondary end point was the occurrence of complications related to the procedures. The risk factors of the occurrence of complications were studied. RESULTS: The proportion of patients with mRS scores ≤2 at 30 days after procedure was 91.3 %. Complications occurred in 15 of the 1,012 patients (1.48 %). Multivariate analysis showed that embolization for tumors other than meningioma (OR, 4.626; 95 % CI, 1.347-14.59; p = 0.0105) was significantly associated with the development of complications. CONCLUSION: The frequency of complications after intracranial tumor embolization was relatively low in this large Japanese cohort. Embolization for tumors other than meningioma was the only significant risk factor for the occurrence of complications.

DOI： 10.1007/s00234-013-1300-4

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Cerebral vasospasm in patients over 80 years treated by coil embolization for ruptured cerebral aneurysms. 国際誌

Tomohito Hishikawa, Yuji Takasugi, Tomohisa Shimizu, Jun Haruma, Masafumi Hiramatsu, Koji Tokunaga, Kenji Sugiu, Isao Date

BioMed research international 2014 253867 - 253867 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECT: The effect on clinical outcomes of symptomatic vasospasm after aneurysmal subarachnoid hemorrhage (SAH) in patients over 80 years who underwent coil embolization was evaluated. METHODS: Forty-four cases were reviewed and divided into two groups according to patient age: Group A, 79 years or younger, and Group B, 80 or older. Patient characteristics, prevalence of symptomatic vasospasm, modified Rankin Scale (mRS) scores at discharge and frequency of symptomatic vasospasm in patients with mRS scores of 3-6 were analyzed. RESULTS: Thirty-two (73%) of the 44 cases were categorized as Group A and 12 (27%) as Group B. Group B had a significantly higher prevalence of symptomatic vasospasm compared to Group A (P=0.0040). mRS scores at discharge were significantly higher in Group B than in Group A (P=0.0494). Among cases with mRS scores of 3-6, there was a significantly higher frequency of symptomatic vasospasm in Group B than in Group A (P=0.0223). CONCLUSIONS: In our cohort of aneurysmal SAH patients treated by coil embolization, patients over 80 years of age were more likely to suffer symptomatic vasospasm, which significantly correlated with worse clinical outcomes, than those 79 years and under.

DOI： 10.1155/2014/253867

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Epidemiology of Dural Arteriovenous Fistula in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2).

Masafuni Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Jun Haruma, Koji Tokunaga, Isao Date, Naoya Kuwayama, Nobuyuki Sakai

Neurologia medico-chirurgica 54 Suppl 2 63 - 71 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）

We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of patients treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of dural arteriovenous fistulas (dAVFs) in the JR-NET2 database. All patients with dAVFs treated with endovascular therapy in 150 Japanese hospitals were included. Patient characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 patients with dAVFs underwent 1,520 endovascular procedures. Of 1,075 patients, 45% were men and 55% were women. The mean age was 65±13 years. The most frequent location of dAVFs was the cavernous sinus (43.6%), followed by the transverse-sigmoid sinus (TSS) (33.4%). Twelve percent of the patients had intracranial hemorrhage, 9% had venous infarction, and 3% had convulsion. The statistically significant independent risk factors of intracranial hemorrhage were TSS, superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical venous reflux (CVR), and varix. Risk factors of venous infarction were age older than 60 years, male sex, TSS, SSS, and CVR. Risk factors of convulsion were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of dAVFs treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

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Epidemiology of dural arteriovenous fistula in Japan: Analysis of Japanese Registry of Neuroendovascular Therapy (JR-NET2).

Masafumi Hiramatsu, Kenji Sugiu, Tomohito Hishikawa, Jun Haruma, Koji Tokunaga, Isao Date, Naoya Kuwayama, Nobuyuki Sakai

Neurologia medico-chirurgica 54 ( 1 ) 63 - 71 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）

We developed the Japanese Registry of Neuroendovascular Therapy 2 (JR-NET2) database and used the information for a retrospective, nation-wide multicenter, observational study to clarify the clinical characteristics, current status of procedures, and outcome of patients treated by neuroendovascular therapy in Japan. In this report, we analyzed the clinical characteristics of dural arteriovenous fistulas (dAVFs) in the JR-NET2 database. All patients with dAVFs treated with endovascular therapy in 150 Japanese hospitals were included. Patient characteristics, clinical presentations, and imaging characteristics were analyzed. A total of 1,075 patients with dAVFs underwent 1,520 endovascular procedures. Of 1,075 patients, 45% were men and 55% were women. The mean age was 65 ± 13 years. The most frequent location of dAVFs was the cavernous sinus (43.6%), followed by the transverse-sigmoid sinus (TSS) (33.4%). Twelve percent of the patients had intracranial hemorrhage, 9% had venous infarction, and 3% had convulsion. The statistically significant independent risk factors of intracranial hemorrhage were TSS, superior sagittal sinus (SSS), tentorium, anterior cranial fossa, cranio-cervical junction, cortical venous reflux (CVR), and varix. Risk factors of venous infarction were age older than 60 years, male sex, TSS, SSS, and CVR. Risk factors of convulsion were male sex, SSS, and CVR. This is the largest nationwide report, to date, of the clinical characteristics of dAVFs treated by neuroendovascular therapy. CVR was a major risk factor of aggressive symptoms.

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