Updated on 2021/12/20

写真a

 
YAMADA Norihito
 
Organization
Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
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Degree

  • 医学博士 ( 1991   岡山大学 )

Research Areas

  • Life Science / Psychiatry

Research History

  • 岡山大学医学部附属病院精神科神経科   助手

    1991.3 - 1998.6

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  • 南和会みどり病院

    1988.10 - 1989.1

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  • 岡山大学医学部附属病院精神科神経科

    1986.4 - 1988.9

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  • 広島市民病院精神科神経科

    1984.4 - 1986.3

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  • 岡山大学医学部附属病院精神科神経科

    1983.4 - 1984.3

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Papers

  • Impairment of early neuronal maturation in anti-NMDA-receptor encephalitis. International journal

    Sojiro Okamoto, Manabu Takaki, Kenji Hinotsu, Hiroki Kawai, Shinji Sakamoto, Yuko Okahisa, Soshi Takao, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Norihito Yamada

    Psychopharmacology   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:SPRINGER  

    RATIONALE: Adequate immunotherapies for anti-NMDAR encephalitis during pregnancy produce a relatively good clinical outcome for pregnant mothers and their infants, but there are no reports about the future growth of their babies. The damage of anti-NMDAR antibodies to early neuronal development is still unknown. OBJECTIVES: Serum or cerebrospinal fluid from one patient with anti-NMDAR encephalitis (the index patient) and one patient with schizophrenia (the control patient) was administered to primary cultures of dissociated rat cortical neurons, and dendritic outgrowth, centrosome elimination, and branching of dendrites were investigated. For rescue experiments, serum of the index patient was replaced with normal culture media after 3 days' administration of the index patient. RESULTS: Serum and cerebrospinal fluid of the index patient statistically significantly impaired dendritic outgrowth of cultured rat cortical primary neurons. Serum of the index patient also statistically significantly delayed centrosome elimination. Impaired dendritic outgrowth and delayed centrosome elimination were not perfectly rescued by changing to normal culture media. Serum of the index patient also statistically significantly reduced the branching of dendrites. CONCLUSIONS: This is the first demonstration of the damage by anti-NMDAR antibodies on early dendritic development in vitro. As a strategy to protect embryonic neurons, our findings may support the efficacy of early immunotherapy for anti-NMDAR encephalitis in pregnancy.

    DOI: 10.1007/s00213-021-06036-x

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  • Encouraging participation in colorectal cancer screening for people with schizophrenia: A randomized controlled trial. International journal

    Masaki Fujiwara, Yuto Yamada, Taichi Shimazu, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Kyoko Kakeda, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Acta psychiatrica Scandinavica   144 ( 4 )   318 - 328   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    OBJECTIVE: We examined the efficacy of a case management approach to improve participation in colorectal cancer screening among people with schizophrenia. METHODS: This was a randomized, parallel group trial. We recruited outpatients with schizophrenia aged 40 years or over from two psychiatric hospitals in Japan. Participants were randomly assigned (1:1) to treatment as usual or case management intervention plus treatment as usual using a web-based system. Attending clinicians and participants were unmasked to the allocation. Case management included education and patient navigation for colorectal cancer screening using a fecal occult blood test. Treatment as usual included direct mail government recommendations. The primary endpoint was participation in colorectal cancer screening assessed using municipal records. We also assessed the secondary endpoint of participation in other cancer screenings (lung, gastric, breast, and cervical). RESULTS: Between 3 June and 9 September 2019, 172 eligible participants were randomly assigned to the case management plus treatment as usual group (n = 86) or treatment as usual group (n = 86). One participant was ineligible and another withdrew consent; both were excluded from analysis. A significantly higher proportion of participants received colorectal cancer screening in the case management plus treatment as usual group than in the treatment as usual group (40 [47.1%] of 85 participants vs. 10 [11.8%] of 85 participants, p < 0.0001). The proportion of lung cancer screening also increased. No serious adverse events associated with the study intervention occurred. CONCLUSION: The case management intervention to encourage participation in colorectal cancer screening was effective for patients with schizophrenia.

    DOI: 10.1111/acps.13348

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  • Cancer care for people with mental disorders: A qualitative survey among cancer care and psychiatric care professionals in Japan. International journal

    Tsuyoshi Etoh, Masaki Fujiwara, Yuto Yamada, Riho Wada, Yuji Higuchi, Shinichiro Inoue, Masafumi Kodama, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Kyoko Kakeda, Taichi Shimazu, Naoki Nakaya, Masahiro Tabata, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Psycho-oncology   30 ( 12 )   2060 - 2066   2021.8

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    OBJECTIVE: It is widely assumed that there are multiple levels (from individual to policy level) of problems involving disparities in cancer care for people with mental disorders. However, few studies have comprehensively investigated issues as perceived by medical professionals. The purpose of the present study was to identify a wide range of issues in cancer care for people with mental disorders and offer corresponding solutions for both cancer care professionals and psychiatric care professionals. METHODS: We distributed open-ended questionnaires to 754 healthcare professionals in various medical facilities, including designated cancer hospitals, psychiatric hospitals, and other local healthcare/welfare facilities. Participants were asked to describe issues in cancer care for people with mental disorders. RESULTS: Of the 754 recruited professionals, 439 (58.2%) responded to the questionnaire. Sixty-one issues were extracted and categorized into 10 categories: patient factors; isolation and lack of support; obstacles to transport; socioeconomic factors; attitudes of psychiatric professionals; medical system of psychiatric hospitals; attitudes of cancer care professionals; medical system of designated cancer hospitals; regional cancer medical systems; and lack of coordination among multidisciplinary healthcare professionals. Forty-eight specific solutions were summarized into 12 goals. CONCLUSIONS: The present study widely identified issues causing disparities in cancer care for patients with mental disorders. We found that the issues extended from the patient level to the public-policy level. Our findings suggest the need for a multidisciplinary approach that includes both cancer and psychiatric care professionals to address the gap in cancer care for people with mental disorders.

    DOI: 10.1002/pon.5780

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  • Prevalence of dementia in people with intellectual disabilities without Down syndrome in Japan

    Shintaro Takenoshita, Ryozo Kuwano, Tomokazu Inoue, Taku Kurozumi, Seishi Terada, Norihito Yamada, Shigeru Suemitsu

    JOURNAL OF APPLIED RESEARCH IN INTELLECTUAL DISABILITIES   34 ( 5 )   1305 - 1305   2021.7

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    Language:English   Publisher:WILEY  

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  • Factors predicting loss of independence and mortality in frontotemporal lobar degeneration. International journal

    Osamu Yokota, Tomoko Miki, Seishi Terada, Norihito Yamada

    Journal of neurology, neurosurgery, and psychiatry   92 ( 7 )   687 - 687   2021.7

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    Language:English   Publisher:BMJ PUBLISHING GROUP  

    DOI: 10.1136/jnnp-2020-325944

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  • Validity and Reliability of the Japanese Version of the 12-item Self-administered World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in Patients with Schizophrenia.

    Riho Wada, Masaki Fujiwara, Yuto Yamada, Naoki Nakaya, Maiko Fujimori, Ryuhei So, Masafumi Kodama, Yuji Higuchi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    Acta medica Okayama   75 ( 3 )   315 - 322   2021.6

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    It is necessary to assess functional impairment when treating schizophrenia. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) has been adopted as a measure of functional disability in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. This study was a secondary analysis from a cross-sectional study of health-related behaviors among patients with schizophrenia. We examined the validity and reliability of the Japanese version of the 12-item WHODAS 2.0 when self-administered by such patients. Participants were 350 outpatients with schizophrenia from a psychiatric hospital. The standard six-factor structure of the WHODAS 2.0 showed a good fit for these participants. The Cronbach's alpha coefficient was 0.858, showing good internal consistency. The WHODAS 2.0 showed moderate correlations with the modified Global Assessment of Functioning and Kessler 6 scales (r=-0.434 and 0.555, respectively). The results of this study show that the Japanese version of the 12-item self-administered WHODAS 2.0 has good internal consistency and convergent validity among patients with schizophrenia. Further exploration of the usefulness of WHODAS 2.0 in clinical settings is needed.

    DOI: 10.18926/AMO/62226

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  • The relationship between plasma clozapine concentration and clinical outcome: a cross-sectional study Reviewed International journal

    Yuji Yada, Kohei Kitagawa, Shinji Sakamoto, Atsushi Ozawa, Akihiro Nakada, Hiroko Kashiwagi, Yuko Okahisa, Soshi Takao, Manabu Takaki, Yoshiki Kishi, Norihito Yamada

    ACTA PSYCHIATRICA SCANDINAVICA   143 ( 3 )   227 - 237   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Objective There is no report that statistically evaluates the therapeutic reference (350-600 ng/ml) and adverse drug reaction (ADR) range (>1000 ng/ml) of clozapine (CLZ) recommended by the Arbeitsgemeinschaft fur Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) consensus guidelines in an isolated and large sampling study.Methods We administered CLZ to 131 Japanese patients with treatment-resistant schizophrenia in a multicenter cross-sectional study. Plasma CLZ concentrations were assayed by high-performance liquid chromatography using trough sampling. The Brief Psychiatric Rating Scale (BPRS) and severe dose-dependent ADR (sedation, myoclonus, and seizures) were analyzed statistically after adjusting for possible confounders.Results The daily CLZ dosage showed a moderately positive relationship with the plasma concentration (r = 0.49, p 0.001). Every 100 ng/ml increase in plasma CLZ concentration improved the total BPRS score 1.95% (95% CI: 0.89-3.01, p 0.001) and the odds ratio (OR) 1.38 (95% CI: 1.14-1.66, p = 0.001) for BPRS response. Compared with concentrations below 350 ng/ml CLZ, 350-600 ng/ml (11.12%; 95% CI: 2.52-19.72, p = 0.012) and 600-1000 ng/ml (11.05%; 95% CI: 2.40-19.71, p = 0.013) showed significant improvement in the total BPRS score. Dosages above 1000 ng/ml showed greater improvement (25.36%; 95% CI: 13.08-37.64, p 0.001) of the total BPRS score but more severe ADRs than dosages below 1000 ng/ml (OR: 31.72; 95% CI: 1.04-968.81, p = 0.048).Conclusion The AGNP therapeutic reference range (350-600 ng/ml) is useful, and a dose above 1000 ng/ml is potentially more effective but carries the risk of severe ADRs in the central nervous system.

    DOI: 10.1111/acps.13264

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  • 【どんな薬剤・合併症・病態・患者背景にも対応できる 周術期の薬の使い方パーフェクトガイド】(第5章)病態に応じた周術期での注意点 精神疾患

    井上 真一郎, 江角 悟, 山本 昌子, 山口 恵, 廣部 貴惠, 井上 尚子, 神崎 あかね, 横林 恵理子, 千田 真友子, 植田 真司, 三宅 俊明, 山田 了士

    薬事   63 ( 3 )   515 - 522   2021.2

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    Language:Japanese   Publisher:(株)じほう  

    <Key Points>・周術期では、内服中の向精神薬を中断することによって精神症状の再燃や副作用(離脱症状など)の出現が懸念されるため、向精神薬は原則として投与を継続する。・術前にベンゾジアゼピン受容体作動薬を内服している場合、せん妄の原因となる可能性があるため、せん妄発症リスクの高い患者では、離脱症状に十分注意しながら可能な限り中止することが望ましい。・術後に内服中の向精神薬を中断せざるをえない場合、その間に精神症状の再燃や副作用の出現が想定されるケースでは、代替薬を検討する必要がある。・向精神薬の代替手段として、剤形の変更(液剤や口腔内崩壊錠などの口腔内投与、錠剤の粉末化による胃管投与)のほか、注射剤(静注、点滴静注、筋注)、貼付剤、坐剤などを用いることがある。(著者抄録)

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  • Facial expression recognition in mild cognitive impairment and dementia: is the preservation of happiness recognition hypothesis true? International journal

    Satoshi Hayashi, Seishi Terada, Shintaro Takenoshita, Yoshiko Kawano, Mayumi Yabe, Nao Imai, Makiko Horiuchi, Tomoko Miki, Osamu Yokota, Norihito Yamada

    PSYCHOGERIATRICS   21 ( 1 )   54 - 61   2021.1

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    Aim Social cognition encompasses facial expression recognition (FER), theory of mind, and empathy. Although studies examining FER in large numbers of patients with mild cognitive impairment (MCI) or dementia are rare, relative preservation of happiness recognition in dementia was reported in some studies. In this study, we examined performance on FER tests and its relationship to clinical demographics and other cognitive function test scores in patients with cognitive decline.Methods The present study administered an FER test and several cognitive tests to outpatients at a memory clinic. The FER test presents four facial expressions (happiness, surprise, anger, and sadness). A total of 187 patients were placed in one of the three groups based on their cognitive status: dementia group (n = 63), MCI group (n = 92), and normal cognition group (n = 32).Results The total scores on the FER test significantly differed among the three groups (normal > MCI > dementia). In the recognition of happiness and surprise, the dementia group had significantly lower scores than the normal cognition group. There were no significant differences in the recognition of anger and sadness scores among the three groups. The FER scores for happiness and surprise were primarily related to executive function scores, but the FER scores for anger and sadness were primarily related to age.Conclusions We note the difference in recognition of causative factors among the four emotions (happiness, surprise, anger, sadness). Our study raises serious doubts about the preservation of happiness recognition hypothesis in dementia based on FER tests.

    DOI: 10.1111/psyg.12622

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  • Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa.

    Koichiro Yamamoto, Daisuke Omura, Mai Yamane, Reina Son, Kou Hasegawa, Hiroyuki Honda, Mikako Obika, Nozomu Minao, Satoru Edahiro, Norihito Yamada, Fumio Otsuka

    Acta medica Okayama   75 ( 5 )   631 - 636   2021

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    Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

    DOI: 10.18926/AMO/62776

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  • Mechanisms underlying the comorbidity of schizophrenia and type 2 diabetes mellitus. International journal

    Yutaka Mizuki, Shinji Sakamoto, Yuko Okahisa, Yuji Yada, Nozomu Hashimoto, Manabu Takaki, Norihito Yamada

    The international journal of neuropsychopharmacology   24 ( 5 )   367 - 382   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:OXFORD UNIV PRESS  

    The mortality rate of patients with schizophrenia is high, and life expectancy is shorter by 10 to 20 years. Metabolic abnormalities including type 2 diabetes mellitus (T2DM) are among the main reasons. The prevalence of T2DM in patients with schizophrenia may be epidemiologically frequent because antipsychotics induce weight gain as a side effect and the cognitive dysfunction of patients with schizophrenia relates to a disordered lifestyle, poor diet, and low socioeconomic status. Apart from these common risk factors and risk factors unique to schizophrenia, accumulating evidence suggests the existence of common susceptibility genes between schizophrenia and T2DM. Functional proteins translated from common genetic susceptibility genes are known to regulate neuronal development in the brain and insulin in the pancreas through several common cascades. In this review, we discuss common susceptibility genes, functional cascades, and the relationship between schizophrenia and T2DM. Many genetic and epidemiological studies have reliably associated the comorbidity of schizophrenia and T2DM, and it is probably safe to think that common cascades and mechanisms suspected from common genes' functions are related to the onset of both schizophrenia and T2DM. On the other hand, even when genetic analyses are performed on a relatively large number of comorbid patients, the results are sometimes inconsistent, and susceptibility genes may carry only a low or moderate risk. We anticipate future directions in this field.

    DOI: 10.1093/ijnp/pyaa097

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  • Electroconvulsive Therapy Is Effective and Safe for Serious Catatonia-Related Ileus Two Case Reports Reviewed International journal

    Yuto Yamada, Masaki Fujiwara, Ryuhei So, Satoru Edahiro, Yukiko Matsui, Shinji Sakamoto, Kiyohiro Kawada, Manabu Takaki, Suguru Ishizu, Keiko Kanazawa, Yoshiki Kishi, Norihito Yamada

    JOURNAL OF ECT   36 ( 4 )   E49 - E51   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1097/YCT.0000000000000686

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  • 岡山大学病院救命救急病棟に入院となった自殺企図患者の臨床的特徴

    植田 真司, 神崎 あかね, 井上 尚子, 山口 恵, 山本 昌子, 江角 悟, 串田 吉生, 三宅 俊明, 松尾 蓮華, 三島 桃子, 千田 真友子, 井上 真一郎, 山田 了士

    総合病院精神医学   32 ( Suppl. )   S - 207   2020.11

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    Language:Japanese   Publisher:(一社)日本総合病院精神医学会  

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  • Validation of the Japanese Version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID). Reviewed

    Takenoshita S, Terada S, Kuwano R, Inoue T, Kurozumi T, Choju A, Suemitsu S, Yamada N

    Journal of Intellectual Disability Research   64 ( 12 )   970 - 979   2020.10

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  • Sally-Anne test and regional cerebral blood flow in Alzheimer's disease dementia International journal

    Shintaro Takenoshita, Satoshi Hayashi, Takayoshi Shinya, Tomoko Miki, Osamu Yokota, Yohko Maki, Hideyuki Hattori, Norihito Yamada, Seishi Terada

    PSYCHOGERIATRICS   20 ( 5 )   549 - 556   2020.9

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    Aim It was recently reported that theory of mind is disturbed in mild Alzheimer's disease dementia (ADD). Some studies have reported reduced scores of ADD patients on false belief tests, even on first-order false belief tests. However, few studies have pursued the neural substrate of false belief tests in patients with ADD in a real-world setting.Methods Sixty-three patients with ADD from outpatient units took the Sally-Anne test and underwent brain single-photon emission computed tomography. Of these patients, 29 answered the Sally-Anne test correctly (successful group) and 34 incorrectly (unsuccessful group). We compared the regional cerebral blood flow between the successful and unsuccessful groups.Results A comparison of the two groups showed a significantly lower uptake in the bilateral posterior cingulate gyrus in the unsuccessful group than in the successful group.Conclusions The posterior cingulate gyrus is known to be particularly activated when individuals remember personal events and infer the mental states of others. We suppose that memory or mentalization in the posterior cingulate gyrus-or both-is essential for patients with ADD to be able to pass the Sally-Anne test.

    DOI: 10.1111/psyg.12533

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  • Trends in smoking rates among individuals with serious psychological distress: Analysis of data from a Japanese national survey, 2007-2016 Reviewed International journal

    Yuji Higuchi, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Yuto Yamada, Riho Wada, Tsuyoshi Etoh, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    PSYCHIATRY RESEARCH   291   113225 - 113225   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:ELSEVIER IRELAND LTD  

    To determine whether the downward trend in the smoking rate over time in Japan differs between individuals with and without serious psychological distress (SPD), we used nationally representative data sets from the 2007, 2010, 2013, and 2016 Comprehensive Survey of Living Conditions of Japan. SPD was defined as a score >= 13 on the six-item Kessler Psychological Distress Scale. We conducted multivariate logistic regression analyses including the interaction terms between SPD and survey year. A total 187,685 participants were included. The interaction terms between SPD and survey year among men were significant for 2010 and 2016 but not for 2013. Among women, the interaction terms between SPD and survey year were not significant for any year. In conclusion, we confirmed that the gap in the rate of smoking between men with SPD and those without SPD decreased from 2007 to 2016. Among women, the gap in the smoking rate between those with SPD and those without SPD remained unchanged. Our findings suggest a need for specific support strategies including pharmacological interventions, especially for women smokers with SPD. Further studies are warranted to identify factors contributing to these sex differences.

    DOI: 10.1016/j.psychres.2020.113225

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  • 重度の心理的苦痛を抱える人々の喫煙率の経時的変化 国民生活基礎調査データの解析

    藤原 雅樹, 樋口 裕二, 中谷 直樹, 藤森 麻衣子, 山田 裕士, 和田 里穂, 江藤 剛, 掛田 恭子, 内富 庸介, 山田 了士, 稲垣 正俊

    精神神経学雑誌   ( 2020特別号 )   S578 - S578   2020.9

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  • 重度の心理的苦痛を抱える人々のがん検診受診率の経時的変化 国民生活基礎調査データの解析

    藤原 雅樹, 樋口 裕二, 中谷 直樹, 藤森 麻衣子, 山田 裕士, 和田 里穂, 江藤 剛, 掛田 恭子, 内富 庸介, 中山 富雄, 山田 了士, 稲垣 正俊

    精神神経学雑誌   ( 2020特別号 )   S578 - S578   2020.9

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  • ミルタザピンで生じたむずむず脚症候群に対しガバペンチンエナカルビルの併用が有用だった重症うつ病の1例. Reviewed

    山田裕士、藤原雅樹、酒本真次、山田了士

    精神神経学雑誌   122 ( 9 )   705 - 705   2020.9

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  • Sally-Anne test and regional cerebral blood flow in Alzheimer's disease dementia. Reviewed

    Takenoshita S, Hayashi S, Shinya T, Miki T, Yokota O, Maki Y, Hattori H, Yamada N, Terada S

    Psychogeriatrics   20 ( 5 )   549 - 556   2020.9

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  • 自閉スペクトラム症を背景にもち断食を試みた自殺企図に対し、治療および社会支援を導入した1例. Reviewed

    加藤朱万理、植田真司、藤原雅樹、松本洋輔、山田了士

    精神神経学雑誌   122 ( 9 )   700 - 701   2020.9

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  • てんかん発作後に精神病症状と生活史健忘を認め、遷延する健忘がてんかん性か解離性かの区別に苦慮した1例. Reviewed

    深尾貴志、藤原雅樹、松本洋輔、山田了士

    精神神経学雑誌   122 ( 9 )   703 - 703   2020.9

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  • Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases International journal

    Tomoko Miki, Osamu Yokota, Takashi Haraguchi, Hideki Ishizu, Masato Hasegawa, Takeshi Ishihara, Shu-ichi Ueno, Shintaro Takenoshita, Seishi Terada, Norihito Yamada

    BRAIN PATHOLOGY   30 ( 4 )   811 - 830   2020.7

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    Granular/fuzzy astrocytes (GFAs), a subtype of "aging-related tau astrogliopathy," are noted in cases bearing various neurodegenerative diseases. However, the pathogenic significance of GFAs remains unclear. We immunohistochemically examined the frontal cortex, caudate nucleus, putamen and amygdala in 105 cases composed of argyrophilic grain disease cases (AGD, N = 26), and progressive supranuclear palsy (PSP, N = 10), Alzheimer's disease (AD, N = 20) and primary age-related tauopathy cases (PART, N = 18) lacking AGD, as well as 31 cases bearing other various neurodegenerative diseases to clarify (i) the distribution patterns of GFAs in AGD, and PSP, AD and PART lacking AGD, (ii) the impacts of major pathological factors and age on GFA formation and (iii) immunohistochemical features useful to understand the formation process of GFAs. In AGD cases, GFAs consistently occurred in the amygdala (100%), followed by the putamen (69.2%) and caudate nucleus and frontal cortex (57.7%, respectively). In PSP cases without AGD, GFAs were almost consistently noted in all regions examined (90-100%). In AD cases without AGD, GFAs were less frequent, developing preferably in the putamen (35.0%) and caudate nucleus (30.0%). PART cases without AGD had GFAs most frequently in the amygdala (35.3%), being more similar to AGD than to AD cases. Ordered logistic regression analyses using all cases demonstrated that the strongest independent factor of GFA formation in the frontal cortex and striatum was the diagnosis of PSP, while that in the amygdala was AGD. The age was not significantly associated with GFA formation in any region. In GFAs in AGD cases, phosphorylation and conformational change of tau, Gallyas-positive glial threads indistinguishable from those in tufted astrocytes, and the activation of autophagy occurred sequentially. Given these findings, AGD, PSP, AD and PART cases may show distinct distributions of GFAs, which may provide clues to predict the underlying processes of primary tauopathies.

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  • Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases. Reviewed

    Miki T, Yokota O, Haraguchi T, Ishizu H, Hasegawa M, Ishihara T, Ueno SI, Takenoshita S, Terada S, Yamada N

    Brain Pathology   30 ( 4 )   811 - 830   2020.7

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  • 福祉の現場から 知的障害を持つ人々の認知症.

    竹之下慎太郎、寺田整司、桑野良三、井上友和、黒住卓、長寿厚志、末光茂、山田了士

    地域ケアリング   22 ( 8 )   40 - 41   2020.7

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  • 拒食と緘黙を呈した16歳女性の治療経過. Reviewed

    中川裕子、富永悟、流王雄太、酒本真次、山田了士

    心身医学   60 ( 4 )   369 - 369   2020.5

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  • Prevalence of dementia in people with intellectual disabilities: Cross-sectional study Reviewed International journal

    Shintaro Takenoshita, Seishi Terada, Ryozo Kuwano, Tomokazu Inoue, Atsushi Cyoju, Shigeru Suemitsu, Norihito Yamada

    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY   35 ( 4 )   414 - 422   2020.4

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    Background There are only a few studies of the prevalence of dementia in people with intellectual disability (ID) without Down syndrome (DS), and there is a large difference in the prevalences between reported studies. Moreover, the prevalence of mild cognitive impairment (MCI) in ID has not been reported. We aimed to evaluate the prevalence of dementia in adults of all ages and the prevalence of MCI in people with ID. Furthermore, we tried to clarify the differences depending on the various diagnostic criteria. Methods The survey included 493 adults with ID at 28 facilities in Japan. The caregivers answered a questionnaire, and physicians directly examined the participants who were suspected of cognitive decline. Dementia and MCI were diagnosed according to ICD-10, DC-LD, and DSM-5 criteria. Results The prevalence of dementia was 0.8% for the 45 to 54 years old group, 3.5% for the 55 to 64 years old group, and 13.9% for the 65 to 74 years old group in people with ID without DS. The prevalence of MCI was 3.1% for patients 45 to 54, 3.5% for patients 55 to 64, and 2.8% for patients 65 to 74 with ID without DS. DSM-5 was the most inclusive in diagnosing dementia and MCI in people with ID. Conclusions People with ID without DS may develop dementia and MCI at an earlier age and higher rate than the general population. Among the diagnostic criteria, DSM-5 was the most useful for diagnosing their cognitive impairment.

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  • Diagnostic utility of the Addenbrooke's Cognitive Examination - III (ACE-III), Mini-ACE, Mini-Mental State Examination, Montreal Cognitive Assessment, and Hasegawa Dementia Scale-Revised for detecting mild cognitive impairment and dementia International journal

    Mayuko Senda, Seishi Terada, Shintaro Takenoshita, Satoshi Hayashi, Mayumi Yabe, Nao Imai, Makiko Horiuchi, Norihito Yamada

    PSYCHOGERIATRICS   20 ( 2 )   156 - 162   2020.3

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    Background Early detection of mild cognitive impairment (MCI) and dementia is important to promptly start appropriate intervention. However, it is difficult to examine a patient using long and thorough cognitive tests in a general clinical setting. In this study, we aimed to investigate the diagnostic validity of the Addenbrooke's Cognitive Examination - III (ACE-III), Mini-ACE (M-ACE), Montreal Cognitive Assessment (MoCA), Hasegawa Dementia Scale-Revised (HDS-R), and Mini-Mental State Examination (MMSE) to identify MCI and dementia. Methods A total of 249 subjects (controls = 50, MCI = 94, dementia = 105) at a memory clinic participated in this study, and took the ACE-III, M-ACE, MoCA, HDS-R, and MMSE. After all examinations had been carried out, a conference was held, and the clinical diagnoses were established. Results The areas under the curve (AUC) of the ACE-III, M-ACE, MoCA, HDS-R, and MMSE for diagnosing MCI were 0.891, 0.856, 0.831, 0.808, and 0.782. The AUC of the ACE-III was significantly larger than those of the MoCA, HDS-R, and MMSE. The AUCs of the ACE-III, M-ACE, MoCA, HDS-R, and MMSE for diagnosing dementia were 0.930, 0.917, 0.854, 0.871, and 0.856. Thus, the AUCs of the ACE-III and M-ACE were significantly larger than those of the MoCA, HDS-R, and MMSE. Conclusion The ACE-III is a useful cognitive instrument to detect MCI. For distinguishing dementia patients from non-dementia patients, the ACE-III and M-ACE are superior to the MoCA, HDS-R, and MMSE.

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  • Patient affect and caregiver burden in dementia International journal

    Yoshiko Kawano, Seishi Terada, Shintaro Takenoshita, Satoshi Hayashi, Yoshitaka Oshima, Tomoko Miki, Osamu Yokota, Norihito Yamada

    PSYCHOGERIATRICS   20 ( 2 )   189 - 195   2020.3

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    Background Numerous studies focusing on the burden of caregivers of dementia patients have been published. However, there have been few studies focusing on positive affect as an important factor affecting the caregiver burden, and only a few studies comparing the caregiver burden between different dementia diseases have been reported. Methods Three hundred and thirty-seven consecutive caregivers of people with dementia participated in this study. The caregiver burden was evaluated by the short version of the Japanese version of the Zarit Burden Interview. Results Positive affect scores had a significant relationship with the scores of the short version of the Zarit Burden Interview. Caregivers for patients with dementia with Lewy bodies or frontotemporal dementia suffered from a greater burden than those for patients with Alzheimer's disease dementia. Conclusions The caregiver burden differed between people caring for patients with different dementia diseases. Positive affect of dementia patients has a significant relationship with caregiver burden, independently from neuropsychiatric symptoms of patients.

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  • 【腎臓リハビリテーションのベストプラクティス】精神科的サポート

    井上 真一郎, 鍋倉 由佳, 小川 加苗, 江角 悟, 山本 昌子, 山口 恵, 廣部 貴惠, 井上 尚子, 川田 清宏, 千田 真友子, 植田 真司, 三宅 俊明, 深尾 貴志, 佐々木 翔平, 山田 了士

    総合リハビリテーション   48 ( 3 )   241 - 246   2020.3

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    <文献概要>はじめに 腎機能障害の患者は,その治療経過中に精神症状を呈することがある.腎臓リハビリテーションにかかわる医療者にとって,それをどのように評価し,いかにかかわればよいかについて知っておくことは,効果的なリハビリテーションを行ううえできわめて重要である.本稿では,腎機能障害の患者によくみられる精神症状を挙げ,評価のプロセスや具体的なかかわり方などについて,精神科医ならびに精神科リエゾンチームの立場からできるだけ具体的に解説したい.

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00780&link_issn=&doc_id=20200311050010&doc_link_id=10.11477%2Fmf.1552201897&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1552201897&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • Patient affect and caregiver burden in dementia. Reviewed

    Kawano Y, Terada S, Takenoshita S, Hayashi S, Oshima Y, Miki T, Yokota O, Yamada N

    Psychogeriatrics   20 ( 2 )   189 - 195   2020.3

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  • Competency of aMCI patients to consent to cholinesterase treatment International journal

    Etsuko Oshima, Shintaro Takenoshita, Risa Iwai, Mayumi Yabe, Nao Imai, Makiko Horiuchi, Naoya Takeda, Yosuke Uchitomi, Norihito Yamada, Seishi Terada

    INTERNATIONAL PSYCHOGERIATRICS   32 ( 2 )   211 - 216   2020.2

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    Background: In medical practice, a patient's loss of competency is a major obstacle when choosing a treatment and a starting treatment program smoothly. A large number of studies have revealed the lack of medical competency in patients with dementia. However, there have been only a few reports focusing on the capacity of patients with mild cognitive impairment (MCI) to make a medical choice. Methods: In this study, we evaluated the competency of 40 patients with amnestic MCI (aMCI) and 33 normal subjects to make a medical choice using the MacArthur Competence Assessment Tool-Treatment (MacCAT-T). We compared the judgement of a team conference using the recorded semi-structured interview with the clinical judgement of a chief clinician. Results: A team conference concluded that 12 aMCI patients had no competency, and the clinical judgement, without any special interview, judged that five aMCI patients had no competency. All subjects in the control groups were judged to be competent to consent to treatment by both clinicians and the team conference. Conclusions: Without supplementary tools such as explanatory documents, not a few patients with aMCI were judged by a team conference to have no competency to consent to therapy even in a relatively simple and easy case. In contrast, clinical physicians tended to evaluate the competency of aMCI patients in a generous manner.

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  • Switching strategies for antipsychotic monotherapy in schizophrenia: a multi-center cohort study of aripiprazole Reviewed International journal

    Yoshiaki Obayashi, Satoshi Mitsui, Shinji Sakamoto, Nozomu Minao, Bunta Yoshimura, Toshiki Kono, Yuji Yada, Yuko Okahisa, Soshi Takao, Yoshiki Kishi, Toshihiko Takeda, Manabu Takaki, Norihito Yamada

    PSYCHOPHARMACOLOGY   237 ( 1 )   167 - 175   2020.1

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    Rationale Changing antipsychotics of patients with chronic schizophrenia involves several risks. Switching to aripiprazole is especially difficult. We investigated switching methods and related factors for successful switching patients with chronic schizophrenia to aripiprazole. Objectives This study was a multi-center historical cohort study and approved by the research ethics committee of Okayama University Hospital and Okayama Psychiatric Medical Center. We compared survival proportions of 178 chronic schizophrenia patients who continued aripiprazole monotherapy for 6 months after non-direct switching (add-on switching (n = 45), cross switching (n = 62)) or direct switching (n = 71). We adjusted possible confounders using a Cox proportional hazards model. Results Of patients with chronic schizophrenia, 56.7% (101/178) were switched to aripiprazole monotherapy, and 55.0% (98/178) showed improvement in symptoms as demonstrated by the Clinical Global Impression Severity score. Kaplan-Meier survival curves showed that non-direct switching had a higher survival proportion than direct switching (log-rank test, p = 0.012). Even after adjusting for several variables using a Cox proportional hazards model, add-on switching had a significantly lower hazard at 6 months than direct switching (hazard ratio 0.42, 95% confidence interval 0.21-0.82, P = 0.01). In cases of switching to aripiprazole for psychiatric symptoms, non-direct switching had a lower hazard than direct switching (hazard ratio 0.41, 95% confidence interval 0.21-0.81, P = 0.01) but was not significant for adverse reaction. When aripiprazole was switched from olanzapine, add-on switch showed the lowest hazard ratio for continuation (hazard ratio 0.29, 95% confidence interval 0.07-1.11, P = 0.07). Conclusions Flexibility in strategies when switching to aripiprazole may induce a better outcome for patients with chronic schizophrenia.

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  • Patient affect and caregiver burden in dementia. Reviewed

    Kawano Y, Terada S, Takenoshita S, Hayashi S, Oshima Y, Miki T, Yokota O, Yamada N

    Psychogeriatrics   20 ( 2 )   189 - 195   2019.11

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  • A randomised controlled trial of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia in psychiatric outpatient clinics: study protocol for the J-SUPPORT 1901 (ACCESS) study Reviewed International journal

    Masaki Fujiwara, Masatoshi Inagaki, Taichi Shimazu, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Maiko Fujimori, Hirokazu Takahashi, Naoki Nakaya, Kyoko Kakeda, Tempei Miyaji, Shiro Hinotsu, Keita Harada, Hiroyuki Okada, Yosuke Uchitomi, Norihito Yamada

    BMJ OPEN   9 ( 11 )   e032955 - e032955   2019.11

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    Introduction One of the reasons for the high mortality rate from cancer in people with schizophrenia is delay in diagnosis. Many studies have shown lower cancer screening rates in people with schizophrenia; however, there are no interventions for people with schizophrenia to increase cancer screening. Therefore, we developed a case management (CM) intervention to encourage participation in cancer screening. The purpose of this study was to examine the efficacy of CM to encourage participation in cancer screening for people with schizophrenia, with particular focus on colorectal cancer screening by faecal occult blood testing, compared with usual intervention (UI), namely, municipal public education.Methods and analysis This is an individually randomised, parallel group trial with blinded outcome assessments. The participants will be randomly allocated to either the CM plus UI group or UI alone group in a 1:1 ratio using a web-based program at a data management centre. The primary end point of the study is participation in colorectal cancer screening in the year of intervention, which will be assessed based on municipal records.

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  • Change in smoking cessation stage over 1 year in patients with schizophrenia: a follow up study in Japan Reviewed International journal

    Yuji Higuchi, Masaki Fujiwara, Naoki Nakaya, Maiko Fujimori, Chinatsu Hayashibara, Ryuhei So, Ikuta Shinkawa, Kojiro Sato, Yuji Yada, Masafumi Kodama, Hiroshi Takenaka, Yoshiki Kishi, Kyoko Kakeda, Yosuke Uchitomi, Norihito Yamada, Masatoshi Inagaki

    BMC PSYCHIATRY   19 ( 1 )   367 - 367   2019.11

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    Background We performed a follow up study about willingness and behaviors to quit smoking among smokers with schizophrenia in Japan. Methods Participants were outpatients with schizophrenia aged 20-69 years who had been visiting the hospital for >= 1 year as of April 1, 2016, and had visited the hospital more than once in the previous 6 months. A baseline survey on smoking behaviors including current smoking status and smoking cessation stage, was administered in 420 participants that were randomly extracted from a patient pool (n = 680) in 2016, and a follow-up survey was administered in 2017. We calculated the distribution and change in smoking cessation stage, number of smokers and nonsmokers after 1 year, and quitting rate from a naturalistic 1-year smoking-cessation follow up. Results The number of baseline respondents was 350; 113 current smokers and 68 former smokers. Among the 113 current smokers, 104 (92.0%) were followed for 1 year, 79 (70.0%) were interested in smoking cessation, and only 7 had received smoking cessation treatments at baseline. Among the tracked 104 participants, only 6 (5.8%) stopped smoking after 1 year. Among the 25 participants who had intentions to quit smoking within 6 months at baseline, 6 (24.0%) maintained their intention to quit smoking for 1 year, and 16 (64.0%) did not maintain their intention to quit smoking. Conclusions Our findings showed that many smokers with schizophrenia were interested in quitting smoking, but few patients received treatment and actually quit smoking. Timely intervention, including the option to receive smoking cessation treatment, is necessary for those patients with schizophrenia who smoke.

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  • 中心静脈栄養中に黄色ブドウ球菌による血流感染を生じた神経性無食欲症の2例

    山田 裕士, 藤原 雅樹, 千田 真友子, 溝渕 真衣子, 酒本 真次, 徳増 一樹, 萩谷 英大, 山田 了士

    総合病院精神医学   31 ( Suppl. )   S - 209   2019.11

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  • 胃液分泌抑制薬の注入、及び中性栄養剤と酸性飲料の配合による胃管閉塞が疑われた2例

    深尾 貴志, 藤原 雅樹, 乾 裕芙, 末吉 典子, 竹内 教子, 石黒 則子, 江角 悟, 山田 裕士, 千田 真友子, 山田 了士

    総合病院精神医学   31 ( Suppl. )   S - 243   2019.11

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  • 岡山大学病院における救命救急病棟への精神科介入の実態と今後の課題について

    植田 真司, 井上 尚子, 廣部 貴惠, 山口 恵, 山本 昌子, 江角 悟, 三宅 俊明, 深尾 貴志, 千田 真友子, 川田 清宏, 井上 真一郎, 山田 了士

    総合病院精神医学   31 ( Suppl. )   S - 186   2019.11

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  • Switching strategies for antipsychotic monotherapy in schizophrenia: a multi-center cohort study of aripiprazole. Reviewed

    Obayashi Y, Mitsui S, Sakamoto S, Minao N, Yoshimura B, Kono T, Yada Y, Okahisa Y, Takao S, Kishi Y, Takeda T, Takaki M, Yamada N

    Psychopharmacology (Berl)   237 ( 1 )   167 - 175   2019.10

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  • Propofolにketamineを併用した麻酔による電気けいれん療法で有効かつ安全に治療し得た難治性統合失調症の2例 Reviewed

    山田 裕士, 藤原 雅樹, 酒本 真次, 冨永 悟, 稲垣 正俊, 松崎 孝, 森松 博史, 山田 了士

    総合病院精神医学   31 ( 4 )   448 - 454   2019.10

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    電気けいれん療法(ECT)は、統合失調症患者においても緊張病状態や薬物治療抵抗例に対して考慮される重要な治療法である。ECTにおいて本邦で頻用される麻酔薬のpropofolは、強い抗けいれん作用を有するため、高い発作閾値が問題になるケースでは麻酔に工夫を要する。発作閾値上昇効果がないとされるketamineへの切り替え、または併用によるpropofolの減量は有効な方法の1つで、うつ病患者では抗うつ効果の増強も期待したketamineによるECTの報告が多い。一方でketamineは、その作用機序から統合失調症の精神症状を悪化させる懸念もある。今回、高い発作閾値が問題化したが、ketamineの併用によりpropofolを減量したECTで有効な発作が得られ、精神病症状の悪化を認めることなく有効かつ安全に治療し得た統合失調症の2例を経験したため報告する。(著者抄録)

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  • MIBG心筋シンチグラフィで取り込み低下を示す高齢うつ病患者の臨床的特徴

    竹之下 慎太郎, 寺田 整司, 大島 悦子, 山口 恵, 林 聡, 樋之津 健二, 江角 悟, 新家 崇義, 河野 禎子, 住友 佳代, 三木 知子, 横田 修, 山田 了士

    Dementia Japan   33 ( 4 )   526 - 526   2019.10

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  • Anti-NMDA-receptor antibody in initial diagnosis of mood disorder Reviewed International journal

    Hiroki Kawai, Manabu Takaki, Shinji Sakamoto, Takashi Shibata, Ayaka Tsuchida, Bunta Yoshimura, Yuji Yada, Namiko Matsumoto, Kota Sato, Koji Abe, Yuko Okahisa, Yoshiki Kishi, Soshi Takao, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Norihito Yamada

    EUROPEAN NEUROPSYCHOPHARMACOLOGY   29 ( 9 )   1041 - 1050   2019.9

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    Anti-NMDAR encephalitis is increasingly recognized as one etiology of psychiatric symptoms, but there is not enough evidence on patients with mood disorder. We assayed anti-NR1/NR2B IgG antibodies in serum and/or cerebrospinal fluid of 62 patients initially diagnosed with mood disorder by a cell-based assay. We also investigated the specific patient characteristics and psychotic symptoms. At first admission, the patients showed only psychiatric symptoms without typical neurological signs or abnormal examination findings. Four of the 62 patients had anti-NR1/NR2B IgG antibodies. The anti-NR1/NR2B IgG antibody-positive patients showed more super- or abnormal sensitivity (P = 0.00088), catatonia (P = 0.049), and more conceptual disorganization (P < 0.0001), hostility (P = 0.0010), suspiciousness (P < 0.0001), and less emotional withdrawal (P < 0.0001) and motor retardation (P < 0.0001) on the Brief Psychiatric Rating Scale than the antibody-negative patients. During the clinical cours(e), anti-NR1/NR2B IgG antibody-positive patients showed more catatonia (P = 0.0042) and met Graus's criteria for diagnosis of anti-NMDAR encephalitis, but negative patients did not. Immunotherapy was effective for anti-NR1/NR2B IgG antibody-positive patients, and there was the weak relationship (R-2 = 0.318) between the anti-NR1/NR2B IgG antibody titer in the cerebrospinal fluid and the Brief Psychiatric Rating Scale score. (C) 2019 Elsevier B.V. and ECNP. All rights reserved.

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  • Diagnostic utility of the addenbrooke's cognitive examination-? (ace-?), mini-ace, mini-mental state examination, montreal cognitive assessment, and hasegawa dementia scale-revised for detecting mild cognitive impairment and dementia. Reviewed

    Senda M, Terada S, Takenoshita S, Hayashi S, Yabe M, Imai N, Horiuchi M, Yamada N

    Psychogeriatrics   20 ( 2 )   156 - 162   2019.8

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  • 精神科病院に通院中の統合失調症患者の禁煙ステージとその後の禁煙行動 アンケートによる縦断調査 Reviewed

    藤原 雅樹, 樋口 裕二, 稲垣 正俊, 中谷 直樹, 藤森 麻衣子, 林原 千夏, 宋 龍平, 新川 郁太, 佐藤 康治郎, 矢田 勇慈, 児玉 匡史, 竹中 央, 来住 由樹, 掛田 恭子, 内富 庸介, 山田 了士

    精神神経学雑誌   ( 2019特別号 )   S436 - S436   2019.6

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  • 緩和医療・在宅医療における3D(認知症・せん妄・うつ病)対応研修会の有用性に関する検証 岡山大学病院精神科リエゾンチームの活動報告

    井上 真一郎, 馬場 華奈己, 井上 尚子, 山口 恵, 江角 悟, 小川 加苗, 鍋倉 由佳, 植田 真司, 吉田 美保, 小田 幸治, 山田 了士

    Palliative Care Research   14 ( Suppl. )   S303 - S303   2019.6

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  • Competency of amci patients to consent to cholinesterase treatment. Reviewed

    Oshima E, Takenoshita S, Iwai R, Yabe M, Imai N, Horiuchi M, Takeda N, Uchitomi Y, Yamada N, Terada S

    Int Psychogeriatr   32 ( 2 )   211 - 216   2019.5

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  • Validation of Addenbrooke's cognitive examination III for detecting mild cognitive impairment and dementia in Japan Reviewed International journal

    Shintaro Takenoshita, Seishi Terada, Hidenori Yoshida, Megumi Yamaguchi, Mayumi Yabe, Nao Imai, Makiko Horiuchi, Tomoko Miki, Osamu Yokota, Norihito Yamada

    BMC GERIATRICS   19 ( 1 )   123 - 123   2019.4

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    BackgroundEarly detection of mild cognitive impairment (MCI) and dementia is very important to begin appropriate treatment promptly and to prevent disease exacerbation. We investigated the screening accuracy of the Japanese version of Addenbrooke's Cognitive Examination III (ACE-III) to diagnose MCI and dementia.MethodsThe original ACE-III was translated and adapted to Japanese. It was then administered to a Japanese population. The Hasegawa Dementia Scale-revised (HDS-R) and Mini-mental State Examination (MMSE) were also applied to evaluate cognitive dysfunction. In total, 389 subjects (dementia=178, MCI=137, controls=73) took part in our study.ResultsThe optimal ACE-III cut-off scores to detect MCI and dementia were 88/89 (sensitivity 0.77, specificity 0.92) and 75/76 (sensitivity 0.82, specificity 0.90), respectively. ACE-III was superior to HDS-R and MMSE in the detection of MCI or dementia. The internal consistency, test-retest reliability, and inter-rater reliability of ACE-III were excellent.ConclusionsACE-III is a useful cognitive test to detect MCI and dementia. ACE-III may be widely useful in clinical practice.

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  • Clinical characteristics of elderly depressive patients with low metaiodobenzylguanidine uptake. Reviewed

    Takenoshita S, Terada S, Oshima E, Yamaguchi M, Hayashi S, Hinotsu K, Esumi S, Shinya T, Yamada N

    Psychogeriatrics   19 ( 6 )   566 - 573   2019.2

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  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Psychiatry Reviewed

    Shinji Sakamoto, Hiroki Kawai, Yuko Okahisa, Ko Tsutsui, Takashi Kanbayashi, Keiko Tanaka, Yutaka Mizuki, Manabu Takaki, Norihito Yamada

    ACTA MEDICA OKAYAMA   73 ( 3 )   189 - 195   2019

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    Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry.

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  • 岡山大学病院におけるせん妄予防対策の変遷とその効果について

    馬場 華奈己, 井上 尚子, 山口 恵, 江角 悟, 山本 昌子, 植田 真司, 中川 裕子, 千田 真友子, 小田 幸治, 吉田 美保, 井上 真一郎, 川田 清宏, 山田 了士

    総合病院精神医学   30 ( Suppl. )   S - 147   2018.11

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  • Restless genital syndrome induced by milnacipran. Reviewed

    Miyake K, Takaki M, Sakamoto S, Kawada K, Inoue S, Yamada N

    Clin Neuropharmacol   41 ( 3 )   109 - 110   2018.5

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  • Augmentation with blonanserin for schizophrenia patient with insufficient response to clozapine. Reviewed

    Takaki M, Takahashi S, Yada Y, Kitagawa K, Kishi Y, Yamada N

    Open Journal of Psychiatry   8 ( 2 )   131 - 136   2018.4

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  • 戸籍の性別の「変更」ではなく「訂正」が認められた46、XX副腎皮質過形成症の2例. Reviewed

    大島義孝、松本洋輔、佐藤俊樹、山田了士

    GID(性同一性障害)学会雑誌   10 ( 1 )   41 - 48   2018.3

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  • Neuropathological comorbidity associated with argyrophilic grain disease. Reviewed

    Yokota O, Miki T, Ikeda C, Nagao S, Takenoshita S, Ishizu H, Haraguchi T, Kuroda S, Terada S, Yamada N

    Neuropathology   38 ( 1 )   82 - 97   2018.2

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  • 外来での悪性リンパ腫治療中、ステロイド投与後に幻覚妄想を伴ううつ症状を呈した一例(会議録/症例報告)

    高橋 優, 北野 絵莉子, 澤原 光彦, 吉村 優作, 和迩 健太, 原 正吾, 北村 直也, 宮崎 哲治, 村上 伸治, 山田 了士

    心身医学   58 ( 1 )   94 - 94   2018.1

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  • 老年精神科専門医のための臨床神経病理学 第8回 タウオパチー(?)

    寺田整司, 横田修, 三木知子, 竹之下慎太郎, 原口俊, 石津秀樹, 黒田重利, 山田了士

    老年精神医学雑誌   28 ( 11 )   1277 - 1289   2017

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  • Positive affect and regional cerebral blood flow in Alzheimer's disease Reviewed

    Hayashi S, Terada S, Sato S, Oshima E, Miki T, Yokota O, Ishihara T, Yamada N

    Psychiatry research   256   15 - 20   2016.10

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  • Behavioral variant of frontotemporal dementia: fundamental clinical issues associated with the prediction of pathological bases. Reviewed

    Miki T, Yokota O, Ishizu H, Kuroda S, Oshima E, Terada S, Yamada N

    Neuropathology   36 ( 4 )   388 - 404   2016.8

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  • The relationship between development of neuronal and astrocytic tau pathologies in subcortical nuclei and progression of argyrophilic grain disease. Reviewed

    Ikeda C, Yokota O, Nagao S, Ishizu H, Oshima E, Hasegawa M, Okahisa Y, Terada S, Yamada N

    Brain Pathol   26 ( 4 )   488 - 505   2016.7

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  • パーキンソン病に合併した心気妄想、昏迷を伴ううつ病に対して修正型電気けいれん療法が有効であった1例(会議録/症例報告)

    真田 順平, 吉村 優作, 高橋 優, 和迩 健太, 宮崎 哲治, 村上 伸治, 澤原 光彦, 末光 俊介, 北村 直也, 石原 武士, 山田 了士, 青木 省三

    精神神経雑誌   117 ( 5 )   379   2015.5

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  • 強迫性障害に対する短期間集中型入院Flooding法の1例(会議録/症例報告)

    渡邉菜保子, 宮崎哲治, 原省吾, 和迩健太, 竹中真理子, 吉村優作, 澤原光彦, 村上伸治, 山田了士, 青木省三

    精神神経学雑誌   116 ( 7 )   636 - 636   2014.7

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  • Fcγ receptors contribute to pyramidal cell death in the mouse hippocampus following local kainic acid injection Reviewed

    S. Suemitsu, M. Watanabe, E. Yokobayashi, S. Usui, T. Ishikawa, Y. Matsumoto, N. Yamada, M. Okamoto, S. Kuroda

    Neuroscience   166 ( 3 )   819 - 831   2010.3

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    Recent studies have demonstrated the contribution of the gamma subunit of the Fc receptor of IgG (FcRγ) to neuronal death following ischemic injury and Parkinson's disease. We examined the role of FcRγ in hippocampal pyramidal cell death induced by kainic acid (KA). FcRγ-deficient mice (FcRγ-/-) and their FcRγ+/+ littermates (wild type, B6) received an injection of KA into the dorsal hippocampus. Pyramidal cell death was quantified 24 and 72 h after the injection. The number of survived pyramidal cells was significantly larger in FcRγ-/- mice than in B6 mice in both the CA1 and CA3. Immunohistochemical and immunofluorescent studies detected FcγRIIB protein in parvalbumin neurons, whereas FcγRIII and FcγRI proteins were detected in microglial cells. No activated microglial cells were detected 24 h after the KA injection in FcRγ-/- mice, whereas many activated microglial cells were present in B6 mice. The production of nitrotyrosine as well as of the inducible nitric oxide synthase and cyclooxygenase-2 proteins, increased by 16 h after the KA injection in B6 mice. In addition, tissue plasminogen activator and metalloproteinase-2 proteins increased. By contrast, the magnitude of oxidative stress and the increase in protease expression were mild in FcRγ-/- mice. Co-injection of a neutralizing antibody against FcγRll and FcγRlll with KA abolished pyramidal cell death and microglial activation. In addition, the neutralizing antibody reduced oxidative stress and expression of proteases. These observations suggested a role for FcγRllB in parvalbumin neurons as well as FcRγ in microglia in pyramidal cell death. © 2010 IBRO.

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  • Corticosteroid-induced psychotic and mood disorders diagnosis defined by DSM-IV and clinical pictures Reviewed

    Ken Wada, Norihito Yamada, Toshiki Sato, Hiroshi Suzuki, Masahito Miki, Yomei Lee, Kazufumi Akiyama, Shigetoshi Kuroda

    Psychosomatics   42 ( 6 )   461 - 466   2001.12

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    The authors investigated long-term outcome and treatment strategy of corticosteroid-induced psychotic and mood disorders as defined by DSM-IV Review of medical records of 2,069 referral patients revealed 18 applicable patients. Their clinical characteristics, longitudinal courses, and treatments were studied. The authors identified 15 patients with mood disorder and 3 patients with psychotic disorder. Increasing doses or resumption of corticosteroids had the strongest influence on the psychiatric course. These two corticosteroid-induced psychiatric disorders may have different pathophysiological substrates closely related to patient vulnerability. Effective psycho-pharmacological treatment options were indicated with consideration being given to the underlying diseases. © 2001 The Academy of Psychosomatic Medicine.

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  • The insular but not the perirhinal cortex is involved in the expression of fully-kindled amygdaloid seizures in rats Reviewed

    Masazumi Kodama, Norihito Yamada, Keiko Sato, Toshiki Sato, Kiyoshi Morimoto, Shigetoshi Kuroda

    Epilepsy Research   46 ( 2 )   169 - 178   2001

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    We have previously reported an important excitatory role of the perirhinal cortex (PRC) in rat kindling development using an immunohistochemistry technique. In this study, we investigated the roles of the PRC and the insular cortex (INS) located rostral to the PRC, in fully-kindled amygdaloid seizures, using a microinjection technique in the rat kindling model of epilepsy. Following the establishment of daily kindling, we investigated the effects of microinjections of procaine hydrochloride, 2-amino-5-phosphonovalerate (APV
    an N-methyl-D-aspartate (NMDA) receptor antagonist) and 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)-quinoxaline (NBQX
    an α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor antagonist). Microinjections of these drugs into the ipsilateral PRC did not suppress kindled seizures. The possibility is that the process of kindling development forms novel seizure-generalization pathways that do not require further activation of the PRC. On the other hand, procaine and APV injected into the ipsilateral INS significantly suppressed kindled seizures. The manner of suppression appeared to be 'all or none'. It is therefore possible that at least the activation of NMDA receptors in the INS is necessary to express generalized kindled amygdaloid seizures. © 2001 Elsevier Science B.V. All rights reserved.

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  • Increased synapsin I immunoreactivity during long-term potentiation in rat hippocampus Reviewed

    Keiko Sato, Kiyoshi Morimoto, Shuji Suemaru, Toshiki Sato, Norihito Yamada

    Brain Research   872 ( 1-2 )   219 - 222   2000.7

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    The level of synapsin I, a synaptic vesicle protein and marker for synaptic activation, was studied 8 h after long-term potentiation (LTP) induction in rat hippocampus in vivo. Quantitative immunohistochemical analysis revealed that synapsin I increased significantly in the molecular layer of the dentate gyrus and the stratum lucidum of CA3, suggesting activation of the granule cells by synaptic input to the dentate gyrus, and persistent enhancement of glutamate release from the axon terminals of the dentate granule cells. (C) 2000 Elsevier Science B.V.

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  • Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy Reviewed

    Shuji Suemaru, Keiko Sato, Kiyoshi Morimoto, Norihito Yamada, Toshiki Sato, Shigetoshi Kuroda

    NeuroReport   11 ( 6 )   1319 - 1322   2000.4

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    Synapsin is a vesicle-associated protein that is thought to be involved in synaptogenesis and neurotransmitter release. In this study, we investigated the repeated amygdala kindling-induced changes in levels of synapsin I, a marker of enhanced synaptic activity, using immunohistochemistry. Eight hours after the last seizure, synapsin I immunoreactivity (IR) was increased bilaterally in the polymorphic zone of the dentate gyrus, the hilus and the stratum lucidum in area CA3 of the hippocampus. However, 4 weeks after the last kindled seizures, synapsin I IR was not significantly changed in any of the brain regions studied. Therefore, the increased levels of synapsin I protein observed in these brain regions early after the last seizure may reflect the plastic changes that occur in the specific neural networks of the hippocampus directly after kindling- induced seizure activity. (C) 2000 Lippincott Williams and Wilkins.

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  • Recurrent cases of corticosteroid-induced mood disorder: Clinical characteristics and treatment Reviewed

    Ken Wada, Norihito Yamada, Hiroshi Suzuki, Yomei Lee, Shigetoshi Kuroda

    Journal of Clinical Psychiatry   61 ( 4 )   261 - 267   2000

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    Background: Corticosteroids often induce steroid psychosis, a collection of heterogeneous syndromes with different pathophysiologic mechanisms. To date, no study has focused specifically on recurrent corticosteroid-induced mood disorders and considered their long-term outcome and treatment strategies. Method: Nine patients whose initial clinical presentation met DSM-IV criteria for a substance-induced mood disorder were identified by a review of medical records. Their clinical characteristics and treatments were examined. Results: All 9 corticosteroid-treated patients had a clinical course of bipolar disorder. Seven patients initially developed a manic or hypomanic state with subacute onset ranging from 1 to 3 months. Six patients had manic episodes accompanied by psychotic features. The proportion of manic episodes relative to total mood episodes of the 9 patients was 65.6%, suggesting manic predominance. Seven patients showed mood episodes that had no direct relationship to corticosteroid therapy and were preceded by various psychosocial stressors. Four of 5 patients who received steroid pulse therapy rapidly became manic or hypomanic. Antidepressants as well as mood stabilizers were useful for treatment of the present 9 patients. Conclusion: Recurrent cases of corticosteroid-induced mood disorder have interesting clinical features, such as subacute onset, manic predominance, frequent accompanying psychotic features, and similar recurrent episodes in association with psychosocial stressors and corticosteroid use. Management, including psychopharmacologic intervention, should be indicated by a consideration of the underlying illnesses and psychosocial stressors.

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  • Add-on polytherapy with antidepressants and its significance in inpatients with major depression Reviewed

    Ken Wada, Norihito Yamada, Takashi Hamamura, Hiroshi Suzuki, Yoshiyuki Nakano, Shigetoshi Kuroda

    Psychiatry and Clinical Neurosciences   53 ( 5 )   557 - 562   1999.10

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    Add-on polytherapy with antidepressant agents was reviewed in 42 inpatients with major depression diagnosed according to the ICD-10 criteria. Twenty-eight (67.7%) patients were treated with two or more antidepressants. The most frequent combination consisted of a tricyclic antidepressant and a non-tricyclic antidepressant. Nineteen (67.8%) patients of the polytherapy group were treated with a dosage equivalent to 150 mg/day of tricyclic antidepressant. Clinically, not every patient with major depression can tolerate the adverse side effects induced by an effective dose of a single tricyclic antidepressant. From this viewpoint, add-on polytherapy with antidepressants could be one of the treatment options, especially for such intolerant patients.

    DOI: 10.1046/j.1440-1819.1999.00605.x

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  • Effects of YM90K, a selective AMPA receptor antagonist, on amygdala-kindling and long-term hippocampal potentiation in the rat Reviewed

    Masazumi Kodama, Norihito Yamada, Keiko Sato, Yoshihiro Kitamura, Fumihiko Koyama, Toshiki Sato, Kiyoshi Morimoto, Shigetoshi Kuroda

    European Journal of Pharmacology   374 ( 1 )   11 - 19   1999.6

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    To investigate the role of α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) type glutamate receptors in epileptic seizures, we examined the antiepileptogenic and anticonvulsant effects of YM90K [6-(1H-imidazol-1-yl)-7-nitro-2,3-(1H,4H)-quinoxalinedione hydrochloride], a potent and selective new AMPA receptor antagonist, in the rat amygdala-kindling model of epilepsy. Pretreatment with YM90K (7.5-30 mg/kg i.p.) markedly retarded the evolution of kindling. Once kindling was established, administration of YM90K (7.5-30 mg/kg i.p.) significantly and dose-dependently suppressed fully kindled seizures. The maximal effects were observed 15-30 min after injection. When the intensity of electrical stimulation was increased to twice the generalized seizure-triggering threshold, the anticonvulsant effects of YM90K were reversed, suggesting that they were due to elevation of the generalized seizure-triggering threshold. Furthermore, an anticonvulsant dose (15 mg/kg) of YM90K affected neither field potentials nor long-term potentiation in the hippocampus in vivo. These results indicate that AMPA receptors play an important role in the seizure expression mechanism and the development of kindling-induced epileptogenesis, and suggest the possible clinical usefulness of AMPA receptor antagonists as antiepileptic drugs.

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  • The role of perirhinal cortex as an excitatory relay point in kindling secondary generalization.

    *Yamada, N., Matsumoto, Y., Sato, T., Kodama, M., Orita, A., Morimoto, K., Kuroda, S.

    Abstr Soc Neurosci   1999.4

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  • Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in rats Reviewed

    Kenro Otsuki, Kiyoshi Morimoto, Keiko Sato, Norihito Yamada, Shigetoshi Kuroda

    Epilepsy Research   31 ( 2 )   101 - 112   1998.7

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    We investigated the anticonvulsant and adverse behavioral effects of lamotrigine (LTG), a novel antiepileptic drug (AED), as well as other conventional AEDs on kindled seizures in rats. We also applied an anticonvulsive dose of LTG in vivo to rats in which the hippocampus had been subjected to long-term potentiation (LTP). LTG potently attenuated limbic- kindled seizures in a dose-dependent fashion, at doses at which animals showed no adverse behavioral effects. LTG was effective in preventing kindled seizures for up to 24 h after a single i.p. administration. The anticonvulsant effects of LTG were reversed when the stimulus current was raised to two or three times the generalized seizure-triggering threshold. Among the AEDs examined, valproate and LTG were the only drugs that engendered a potent anticonvulsant effect without concomitant adverse behavioral effects. Although all of the other AEDs exhibited anticonvulsant effects with various potencies, they produced adverse effects such as sedation or motor ataxia. Furthermore, an anticonvulsant dose of LTG did not affect either the induction or maintenance of tetanus-induced LTP in the hippocampus. These results indicate that LTG potently suppresses limbic- kindled seizures by raising the seizure triggering-threshold in the kindling focus at doses that do not affect LTP in the hippocampus.

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  • Time-dependent changes in neurotrophic factor mRNA expression after kindling and long-term potentiation in rats Reviewed

    Kiyoshi Morimoto, Keiko Sato, Soichiro Sato, Norihito Yamada, Toshiyuki Hayabara

    Brain Research Bulletin   45 ( 6 )   599 - 605   1998.4

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    We compared the time-dependent changes in messenger ribonucleic acid (mRNA) levels for two neurotrophic factors after amygdala-kindled seizures and hippocampal long-term potentiation (LTP) in rats in vivo. The brain- derived neurotrophic factor (BDNF) mRNA levels in the bilateral granule cell layer of the dentate gyrus, increased significantly 1-4 h after stage 5 kindled seizures. Nerve growth factor (NGF) mRNA levels increased throughout the bilateral limbic regions more gradually than those of BDNF mRNA. The maximum levels in the dentate gyrus ipsilateral to stimulation (BDNF mRNA: 493%, NGF mRNA: 199% of control levels) occurred 2 h after seizures. As observed with kindling, BDNF and NGF mRNA expression increased in the dentate gyrus ipsilateral to stimulation also increased following LTP induced by the perforant path stimulation, with maximum levels occurring 2 h and 4 h, respectively, after stimulation, when they reached 284% and 189% of the control levels, respectively. These results suggest that BDNF and NGF are involved in enhancement of synaptic efficacy in the granule cells of the dentate gyrus in the hippocampus in kindling, not related to the neuronal excitability associated with seizure activity.

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  • Time-dependent changes in rat hippocampal synapsin I mRNA expression during long-term potentiation Reviewed

    Kiyoshi Morimoto, Keiko Sato, Soichiro Sato, Norihito Yamada, Toshiyuki Hayabara

    Brain Research   783 ( 1 )   57 - 62   1998.2

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    We studied the time-dependent changes in synapsin I mRNA levels after hippocampal long-term potentiation (LTP) in rats in vivo. Following LTP induction by stimulating the perforant path, synapsin I mRNA expression in the granule cell layer of the denture gyms ipsilateral to stimulation increased significantly in a time-dependent manner. From 2 to 8 h after stimulation, the synapsin I mRNA levels in the ipsilateral dentate gyms were significantly higher than those of controls subjected to a sham procedure. The synapsin I mRNA level (157.4 ± 7.1% of the control level, mean ± SEM) was at a maximum 8 h after stimulation. The synapsin I mRNA level of animals that received only test pulses did not increase significantly, compared with the control level. These results suggest that the increased level of synapsin I mRNA is related to persistent enhancement of synaptic activity within the neural networks in which dentate granule cells participate in LTP.

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  • Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats Reviewed

    Toru Hirao, Kiyoshi Morimoto, Yoshitaka Yamamoto, Takemi Watanabe, Hitoshi Sato, Keiko Sato, Soichiro Sato, Norihito Yamada, Koichi Tanaka, Hiroshi Suwaki

    Molecular Brain Research   54 ( 1 )   49 - 55   1998.2

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    To investigate the role played by GABA transporters in epileptic seizures, we examined time-dependent and regional changes in expression of GAT-1 and GAT-3 GABA transporter mRNA in amygdala-kindled rat brain using an in situ hybridization method. GAT-1 mRNA was significantly increased bilaterally in the hippocampal dentate gyrus (111-116%) at 1 h after kindled generalized seizures. GAT-1 mRNA was also significantly increased bilaterally in the hippocampal subfields (CA1-4 and dentate gyrus [110-117%]) at 4 h after kindled seizures. There were no significant changes in GAT-1 mRNA level in the amygdalar nuclei, pyriform cortex or cerebral cortex either ipsilaterally or contralaterally at any time after kindled seizures. In contrast, GAT-3 mRNA was significantly increased bilaterally in the amygdalar nuclei and in the contralateral pyriform cortex and cerebral cortex I h after seizures. Since all these changes returned to control levels by 8 or 24 h after kindled seizures, the increases in GABA transporter mRNA appeared to be transient responses to seizure activity. These findings indicate that GAT-1 subtype transporter is specifically involved in seizure activity in the hippocampus, while GAT-3 subtype transporter is mainly involved in seizure activity in the amygdalar nuclei and pyriform cortex following amygdala-kindled generalized seizures.

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  • Increases in mRNA levels for synapsin I but not synapsin II in the hippocampus of the rat kindling model of epilepsy Reviewed

    Kiyoshi Morimoto, Keiko Sato, Soichiro Sato, Shuji Suemaru, Toshiki Sato, Norihito Yamada, Toshiyuki Hayabara

    Seizure   7 ( 3 )   229 - 235   1998

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    We studied brain synapsin I and II mRNA levels using the amygdala kindling model of epilepsy. There were significant increases in the synapsin I mRNA level in the granule cell layer of the hippocampal bilateral dentate gyrus. One to 8 h after seizures, the level in the dentate gyrus ipsilateral to stimulation increased by 44.2-73.2%, compared with the control level. Of the time points investigated, the greatest increase in expression was observed 8 h after the kindled seizures. Furthermore, the synapsin I mRNA levels in the dentate gyrus contralateral to stimulation increased by 28.0% and 51.1%, 2 and 8 h, respectively, after the kindled seizures. Expression of this mRNA, however, did not change significantly in other areas examined, including CA1, CA2, CA3 and the polymorphic layer of the hippocampus and the perirhinal and temporal cortices. Synapsin II mRNA levels did not change significantly in any of the regions studied for up to 24 h after the seizures and synapsin II was presumed to have little involvement in kindling. We considered the locally elevated synapsin I mRNA levels in the bilateral dentate gyrus associated with kindling indicate that excitatory changes occur in the synaptic circuit in which the dentate granule cells participate. Synapsin I may be involved in the presynaptic molecular mechanisms underlying the neuronal plasticity in kindling.

    DOI: 10.1016/S1059-1311(98)80041-1

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  • BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy Reviewed

    Kiyoshi Morimoto, Hitoshi Sato, Keiko Sato, Soichiro Sato, Norihito Yamada

    European Journal of Pharmacology   339 ( 1 )   11 - 15   1997.11

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    We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5- trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy. BW1003C87 (2.5-10 mg/kg, i.p.) had potent and long-lasting (48 h after single administration) effects on amygdala-kindled seizures. The effects of BW1003C87 were completely reversed when the stimulus intensity was increased to 2 or 3 times the threshold determined. Since the same effects on seizure threshold were obtained for phenytoin and carbamazepine in the present study and for lamotrigine in our previous study, we propose that the principal mechanism of these antiepileptic drugs, which act primarily on voltage- sensitive Na+ channels, is significant elevation of the seizure threshold in epileptogenic loci and that BW1003C87 has a profile similar to that of these drugs.

    DOI: 10.1016/S0014-2999(97)01347-2

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  • Characterization of epileptiform field potentials recorded in the in vitro perirhinal cortex of amygdala-kindled epileptogenesis Reviewed

    Yosuke Matsumoto, Norihito Yamada, Kiyoshi Morimoto, David K. Bilkey, Shigetoshi Kuroda

    Brain Research   741 ( 1-2 )   44 - 51   1996.11

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    The perirhinal cortex (PRC) has recently been reported that the excitatory role of this area is important for the generation and the propagation of kindled seizures. In the present study, we investigated the extracellular electrophysiological properties of the circuitry which contribute to the propagation of seizures in the PRC, and examined the hypothesis that amygdala-kindling changes the electrophysiological nature of the rat PRC slice in vitro. Field potentials elicited in the PRC had extended duration (&gt
    200 ms, most ≃ 1 s) with overlying spike components. The potentials showed strong synchronizing effect governed by an all-or-none rule. Although spontaneous epileptiform discharges that were equivalent in appearance to synaptically-activated field potentials were observed in the PRC of both amygdala-kindled and control rats, the number of slices showing spontaneous activity was significantly larger in the kindled group than in the control group (χ2-test, P &lt
    0.01). The occurrence of tetanus-induced afterdischarges in kindled rats was significantly higher than in control rats (χ2-test, P &lt
    0.01). The afterdischarge durations of control slices were generally short and the afterdischarges did not consist of the typical 'tonic-clonic' phases. However, the occurrence of the electrographical seizure in the high K+ ACSF were not affected by amygdala-kindling operation. These results indicate that amygdala-kindling lowers the threshold for transsynaptic excitability and enhances the synchronized activity of the PRC induced by episodic proconvulsive manipulations such as tetanus stimulation.

    DOI: 10.1016/S0006-8993(96)00878-5

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  • Perirhinal cortical kindling: A behavioral and immunohistochemical study Reviewed

    T. Sato, N. Yamada, Y. Kitamura, K. Otsuki, A. Orita, S. Uemura, K. Morimoto, S. Kuroda

    Epilepsia   37 ( 3 )   67   1996

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    DOI: 10.1111/j.1528-1157.1996.tb01831.x

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  • Regional increase in β subunit but not α subunit of calmodulin kinase II mRNA in kindling Reviewed

    K. Sato, K. I. Kashihara, K. Morimoto, N. Yamada, T. Hayabara, S. Kuroda

    Epilepsia   37 ( 3 )   111 - 112   1996

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    DOI: 10.1111/j.1528-1157.1996.tb01885.x

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  • Primary and secondary kindling in the cat perirhinal cortex Reviewed

    A. Orita, T. Moriwake, N. Yamada, K. Ootsuki, T. Norikiyo, K. Miyanagi, Y. Matsumoto, K. Morimoro, S. Kuroda

    Epilepsia   37 ( 3 )   112   1996

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    DOI: 10.1111/j.1528-1157.1996.tb01886.x

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  • NBQX, a selective antagonist of the AMPA receptor, affects neither field potentials nor long-term potentiation in vivo Reviewed

    Keiko Sato, Kiyoshi Morimoto, Norihito Yamada, Shigetoshi Kuroda, Toshiyuki Hayabara

    Brain Research   683 ( 2 )   279 - 282   1995.6

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    NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline), a selective antagonist of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, at an anticonvulsant dose of 40 mg/kg (i.p.), was shown in vivo to have no effects on either the field potentials in the piriform cortex or those in the dentate gyrus of the hippocampus. The same dose of NBQX also exerted no significant effects on long-term potentiation in the hippocampus. These results suggest that the mechanism underlying the anticonvulsant action of NBQX in vivo does not involve a suppressive action on physiological synaptic transmission. The possible clinical usefulness of AMPA receptor antagonists as antiepiletic drugs is suggested. © 1995.

    DOI: 10.1016/0006-8993(95)00266-S

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  • Epileptic activity in the cat perirhinal cortex in response to amygdala kindling Reviewed

    A. Orita, T. Moriwake, N. Yamada, K. Otsuki, T. Norikiyo, Y. Matsumoto, K. Morimoto, S. Kuroda

    Psychiatry and Clinical Neurosciences   49 ( 3 )   S290 - S292   1995

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    DOI: 10.1111/j.1440-1819.1995.tb02212.x

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  • Regional increase in brain-derived neurotrophic factor and nerve growth factor, but not acidic and basic fibroblast growth factor, mRNA in kindling Reviewed

    K. Sato, K. Kashihara, K. Morimoto, K. Otsuki, Y. Fujiwara, K. Akiyama, N. Yamada, T. Hayabara, S. Kuroda

    Psychiatry and Clinical Neurosciences   49 ( 3 )   S219 - S221   1995

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    DOI: 10.1111/j.1440-1819.1995.tb02180.x

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  • Induction of c-fos and reduction of dynorphin in dentate granule cells of a rat model of epilepsy produced by systemic administration of kainic acid: An immunohistochemical study Reviewed

    Y. Kitamura, S. Uemura, T. Sato, N. Yamada, K. Morimoto, A. Mori, H. Kimura

    Psychiatry and Clinical Neurosciences   49 ( 3 )   S213 - S216   1995

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    DOI: 10.1111/j.1440-1819.1995.tb02178.x

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  • Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy Reviewed

    Tazuko Namba, Kiyoshi Morimoto, Keiko Sato, Norihito Yamada, Shigetoshi Kuroda

    Brain Research   638 ( 1-2 )   36 - 44   1994.2

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    To investigate the role of non-NMDA receptors in epileptic seizures, we examined the antiepileptogenic and anticonvulsant effects of NBQX (2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)-quinoxaline), a potent and selective AMPA receptor antagonist, in the rat kindling model. Systemic administration of 10-40 mg/kg NBQX significantly and dose dependently suppressed previously kindled seizures from the amygdala (AM), assessed in terms of the motor seizure stage and afterdischarge (AD) duration. The maximal effects were observed at 0.5-1 h after drug injection. When the intensity of electrical stimulation was increased to twice the generalized seizure-triggering threshold (GST), the anticonvulsant effects of NBQX on AM-kindled seizures were not reversed, suggesting that the effects were not due to non-specific elevation of the GST. In contrast to AM-kindled seizures, 20-40 mg/kg NBQX significantly suppressed only the motor seizure stage without reducing the AD duration of previously hippocampal-kindled seizures. Daily administration of 15 or 30 mg/kg NBQX prior to each electrical stimulation of the AM markedly and significantly suppressed the development of kindling. During drug sessions, the growth of the AD duration was blocked almost completely, while the waveform of ADs became more complex. These results indicate that NBQX has potent antiepileptogenic and anticonvulsant actions on kindling, at least more from the AM and that non-NMDA receptors have an important role in seizure propagation. © 1994.

    DOI: 10.1016/0006-8993(94)90630-0

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  • Excitatory Changes of Rat Perirhinal Cortex by Amygdala‐Kindling: A Study with In Vitro Slice Technique Reviewed

    Yosuke Matsumoto, Norihito Yamada, Kiyoshi Morimoto, Yukito Shimizu, Tazuko Namba, Yoshihiro Kitamura, Shigetoshi Kuroda

    Psychiatry and Clinical Neurosciences   48 ( 2 )   293 - 298   1994

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    DOI: 10.1111/j.1440-1819.1994.tb03071.x

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  • The effects of perinatal anoxia or hypoxia on hippocampal kindling development in rats Reviewed

    Keiko Sato, Kiyoshi Morimoto, Hiroshi Ujike, Teruo Yamada, Norihito Yamada, Shigetoshi Kuroda, Toshiyuki Hayabara

    Brain Research Bulletin   35 ( 2 )   167 - 170   1994

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    The effects of anoxia and hypoxia (3% oxygen) at 10-12 post days of age on the development of ventral hippocampal kindling and its transfer to the contralateral ventral hippocampus were studied in adult male Sprague-Dawley rats. During oxygen deprivation, the heart rate decreased to 15% of the prehypoxic value in the animals exposed to anoxia and 40% in those exposed to hypoxia. As is observed in asphyxia of human newborns, our study included both ischemia and hypoxia. The susceptibility to kindling, which was measured by kindling rate, afterdischarge threshold, generalized seizure threshold, and total afterdischarge duration to stage 5, had a tendency to be enhanced in rats exposed to hypoxia compared with controls. The facilitating effects on primary site kindling were enhanced in the animals exposed to hypoxia compared with those exposed to anoxia. Transfer, which was indicated by kindling rate and afterdischarge threshold, was also slightly facilitated in the rats exposed to anoxia or hypoxia in the perinatal period. These results reveal that perinatal oxygen deficiency may not be sufficient to lead to the development of temporal lobe epilepsy. However, it is possible that perinatal hypoxia results in some pathophysiological change in the brain which leads to greater seizure susceptibility in adulthood. © 1994.

    DOI: 10.1016/0361-9230(94)90098-1

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  • Antiepileptogenic action of 7-chlorokynurenic acid on amygdala kindling of rats Reviewed

    Tazuko Namba, Kiyoshi Morimoto, Norihito Yamada, Saburo Otsuki

    Pharmacology, Biochemistry and Behavior   46 ( 2 )   275 - 281   1993

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    To investigate the role of strychnine-insensitive glycine receptors in epilepsy, we studied the effects of 7-chlorokynurenic acid (7-CK), a selective strychnine-insensitive glycine receptor antagonist, on amygdala kindling development and previously amygdala-kindled seizures in rats. ICV administration of 7-CK (10 or 20 μg) suppressed amygdala kindling development, assessed according to the motor seizure stage and afterdischarge development, in a dose-dependent manner. However, 7-CK had no significant effect on previously kindled seizures at either of these doses nor did 20 μg at any time (15 min, 30 min, 2 h, and 24 h) after injection studied. These results demonstrate that this selective strychnine-insensitive glycine receptor antagonist has antiepileptogenic activity and suggest a role for the glycine receptors in the contribution of the NMDA receptor complex to epileptogenic events. © 1993.

    DOI: 10.1016/0091-3057(93)90353-U

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  • Epileptogenesis in Perirhinal Cortex In Vitro Reviewed

    Norihito Yamada, Yosuke Matsumoto, Kiyoshi Morimoto, David K. Bilkey

    Psychiatry and Clinical Neurosciences   47 ( 2 )   320 - 321   1993

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    DOI: 10.1111/j.1440-1819.1993.tb02089.x

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  • Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/ pyriform cortex of deep prepiriform cortical kindled rats Reviewed

    Kazufumi Akiyama, Akihiro Daigen, Norihito Yamada, Takashi Itoh, Ichiro Kohira, Hiroshi Ujike, Saburo Otsuki

    Brain Research   569 ( 1 )   71 - 77   1992.1

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    We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats1,2,37. This finding indicates that enhanced function of the PPI-coupled excitatory amino acid (EAA) receptor may be associated with the long-lasting seizure susceptibility of kindling. The present study further examined PPI hydrolysis induced by trans-ACPD, a selective agonist of the metabotropic EAA receptor, as well as by IBO in brain slices of rats kindled from the deep prepiriform cortex (DPC). IBO-stimulated accumulation of [3H]inositol monophosphate ([3H]InsP) was significantly increased in the AM/PC by 162 (P &lt
    0.0001), 130 (P &lt
    0.005) and 81% (P &lt
    0.03) at 24 h, 7 days and 28 days, respectively, after the last kindled seizure, whereas it was increased significantly only at 24 h after the last seizure in the HIPP and did not change at any time in the limbic forebrain (LFB). The IBO-stimulated accumulation of [3H]InsP was significantly increased by 55% (P &lt
    0.01) in the AM/PC of partially kindled rats reaching an average stage of 3.7, but not in the AM/PC of those remaining at stage 1,7 days after the last kindled seizure. Trans-ACPD-stimulated PPI hydrolysis was significantly increased in the AM/PC of DPC-kindled rats by 65 (P &lt
    0.05) and 45% (P &lt
    0.005) at 7 and 28 days, respectively, after the last kindled seizure. Cis-ACPD-stimulated PPI hydrolysis was also significantly increased in the AM/PC of DPC-kindled rats by 45 (P &lt
    0.03) and 30% (P &lt
    0.04) at 7 and 28 days, respectively, after the last seizure. There was no increase in trans-ACPD- or cis-ACPD-stimulated PPI hydrolysis in the HIPP or LFB. These results further confirm our previous studies showing that the metabotropic EAA receptor-stimulated PPI hydrolysis exhibited a long-lasting increase in the AM/PC irrespective of the primary stimulation site for kindling. © 1992.

    DOI: 10.1016/0006-8993(92)90370-O

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  • Kindling: Effects of Strychnine‐Insensitive Glycine Receptor Antagonist (7‐Chlorokynurenic Acid) on Amygdala Kindling in Rats Reviewed

    Tazuko Namba, Kiyoshi Morimoto, Kahoru Katayama, Koutaro Inoue, Norihito Yamada, Saburo Otsuki

    Psychiatry and Clinical Neurosciences   46 ( 2 )   513 - 515   1992

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    DOI: 10.1111/j.1440-1819.1992.tb00919.x

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  • Hippocampal kindling enhances excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the hippocampus and amygdala/pyriform cortex Reviewed

    Norihito Yamada, Kazufumi Akiyama, Saburo Otsuki

    Brain Research   490 ( 1 )   126 - 132   1989.6

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    We recently demonstrated that a long-lasting increase in ibotenate-stimulated polyphosphoinositide (PPI) hydrolysis in the amygdala/pyriform cortex (AM/PC) is associated with seizure susceptibility of amygdala (AM)-kindled rats. The present study examined (1) whether ibotenate-stimulated PPI hydrolysis would be lastingly enhanced in the hippocampus (HIPP) and AM/PC of the HIPP-kindled rats and (2) whether similar changes would be found in the early stage of HIPP kindling. Although ibotenate-stimulated accumulation of [3H]inositol 1-phosphate ([3H]IP1) increased significantly in the HIPP 24 h, 5 days, and 15 days after the last seizure of fully developed HIPP-kindled rats, no statistically significant increase was found in the HIPP 30 days after the last seizure. In the AM/PC, 10-3 M ibotenate-stimulated [3H]IP1 accumulation significantly increased by 91%, 91%, 86% and 90%, 24 h, 5 days, 15 days and 30 days after the last seizure, respectively. There was no significant increase in ibotenate-stimulated [3H]IP1 accumulation 7 days after the last stimulation in the HIPP and AM/PC of rats which had undergone electrical stimulation only 5 times in the HIPP. These results indicate that (1) PPI hydrolysis coupled to excitatory amino acid receptors increases long-lastingly in the AM/PC regardless of the primary kindled site, and (2) these changes do not occur in the early stage of HIPP-kindling. © 1989.

    DOI: 10.1016/0006-8993(89)90437-X

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  • Lasting increase in excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of amygdala-kindled rats Reviewed

    Kazufumi Akiyama, Norihito Yamada, Saburo Otsuki

    Brain Research   485 ( 1 )   95 - 101   1989.4

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    We previously demonstrated that ibotenate-stimulated polyphosphoinositide hydrolysis, determined as the accumulation of [3H]inositol 1-phosphate, significantly increase in the amygdala/pyriform cortex (AM/PC) 24 h and 7 days after the last seizure in AM-kindled rats. The present study examined whether the increase in ibotenate-stimulated polyphosphoinositide hydrolysis in the AM/PC is longer lasting. AM-kindled rats with a tripolar electrode implanted into the left AM and sham-operated controls were decapitated either 1, 2 or 4 weeks after the last seizure. Ibotenate (10-3 M)-stimulated accumulation of [3H]inositol 1-phosphate significantly increased by 90% (P &lt
    0.01), 110% (P &lt
    0.051) and 73% (P &lt
    0.05) in the AM/PC 1, 2 and 4 weeks, respectively, after the last seizure. Four weeks after the last seizure, there were significant increases of a similar magnitude in the contralateral (right) AM/PC (by 83%, P &lt
    0.001) and the ipsilateral (left) AM/PC (by 63%, P &lt
    0.01). There was no change in the hippocampus or limbic forebrain at any of these times. Also 4 weeks after the last seizure, accumulation of [3H]inositol 1-phosphate significantly (P &lt
    0.05) increased at ibotenate concentrations of 2 × 10-4 M, 5 × 10-4 M and 10-3 M in the kindled AM/PC. In light of the view that the AM/PC are the crucial brain structures for sustaining seizure susceptibility, the marked and lasting increase in the ibotenate-stimulated polyphosphoinositide hydrolysis coupled to excitatory amino acid receptors in the kindled AM/PC may be associated with the development of kindling and long-term maintenance of kindled events. © 1989.

    DOI: 10.1016/0006-8993(89)90670-7

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  • Long‐Term Enhancement of Excitatory Amino Acid Receptor‐Mediated Polyphosphoinositide Hydrolysis in the Hippocampus and Amygdala/Pyriform Cortex of Hippocampal Kindled Rats Reviewed

    Norihito Yamada, Kazufumi Akiyama, Akihiro Daigen, Hiroshi Nishikawa, Hiroshi Ujike, Kiyoshi Morimoto, Mitsumoto Sato, Saburo Otsuki

    Psychiatry and Clinical Neurosciences   43 ( 3 )   565 - 566   1989

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    DOI: 10.1111/j.1440-1819.1989.tb02985.x

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  • Lasting Increase in Excitatory Amino Acid Receptor‐Mediated Phosphoinositide Hydrolysis in the Amygdala/Pyriform Cortex of Amygdaloid Kindled Rats Reviewed

    Kazufumi Akiyama, Norihito Yamada, Hiroshi Ujike, Hiroshi Nishikawa, Kiyoshi Morimoto, Motoi Okamoto, Mitsumoto Sato, Saburo Otsuki

    Psychiatry and Clinical Neurosciences   42 ( 3 )   620 - 621   1988

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    DOI: 10.1111/j.1440-1819.1988.tb01383.x

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  • Effect of Chronic Administration of Haloperidol (Intermittently) and Haloperidol‐Decanoate (Continuously) on D2 Dopamine and Muscarinic Cholinergic Receptors and on Carbachol‐Stimulated Phosphoinositide Hydrolysis in the Rat Striatum Reviewed

    Kazufumi Akiyama, Mitsumoto Sato, Norihito Yamada, Saburo Otsuki

    Psychiatry and Clinical Neurosciences   41 ( 2 )   311 - 320   1987

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    Abstract: It has been reported that apomorphine‐induced stereotypy is sensitized after a chronic intermittent administration of haloperidol (HPD), but not after a chronic continuous exposure to haloperidol‐decanoate (HPD‐D). The present study was undertaken to investigate changes in the D2 dopamine and muscarinic receptors in the ratstriatum after the administration of HPD intermittently and HPD‐D continuously. The number of striatal [3H] spiperone binding sites increased significantly after HPD‐D, but did not change after HPD. Neither the number of [3H](–)QNB binding sites nor carbachol‐stimulated phosphoinositide hydrolysis changed after either HPD or HPD‐D. These results indicate that the increase in striatal D2 receptors in rats administered HPD‐D represents behavioral and biochemical tolerance, and that neither the D2 dopamine receptor supersensitivity nor muscarinic receptor hyposensitivity underlies sensitization of apomorphine‐induced stereotypy. Copyright © 1987, Wiley Blackwell. All rights reserved

    DOI: 10.1111/j.1440-1819.1987.tb00417.x

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  • Increase in ibotenate-stimulated phosphatidylinositol hydrolysis in slices of the amygdala/pyriform cortex and hippocampus of rat by amygdala kindling Reviewed

    Kazufumi Akiyama, Norihito Yamada, Mitsumoto Sato

    Experimental Neurology   98 ( 3 )   499 - 508   1987

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    Hydrolysis of membrane phospholipid phosphoinositides following ibotenate stimulation of an excitatory amino acid receptor subtype has recently been demonstrated to be a receptor-mediated biochemical response. The present study examined ibotenate-stimulated phosphoinositides hydrolysis, determined as accumulation of [3H]-inositol 1-phosphate, in amygdala/pyriform cortical and hippocampal slices of amygdala-kindled rats which exhibited fully developed kindled seizures on 20 consecutive days. Animals which underwent a sham operation were used as controls. Ibotenate (10-3 M)-stimulated accumulation of [3H]inositol 1-phosphate increased significantly by 191% in the amygdala/pyriform cortex (P &lt
    0.01) and by 59% in the hippocampus (P &lt
    0.05) of the amygdala-kindled rats killed 24 h after the last seizure. One week after the last seizure, a similar magnitude of significant increase (by 171%, P &lt
    0.05) was maintained in the amygdala/pyriform cortex of the amygdala-kindled rats. In contrast, the increase in the hippocampus had attenuated by this time, although accumulation of [3H]inositol 1-phosphate increased significantly (P &lt
    0.05) when stimulated by 10-4 M ibotenate. These results suggest that enhancement of ibotenate-stimulated phosphoinositides hydrolysis in the amygdala/pyriform cortex may be associated with the long-lasting seizure susceptibility of amygdala-kindled rats. © 1987.

    DOI: 10.1016/0014-4886(87)90259-7

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Books

  • てんかん学専門医ガイドブック改訂第2版

    山田了士( Role: Sole author ,  精神症状の診断 てんかんの診断.)

    診断と治療社  2020.12  ( ISBN:9784787824172

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    Responsible for pages:pp51-55   Language:Japanese

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  • がんと認知機能障害 気づく,評価する,支援する

    山田了士( Role: Sole author ,  9.てんかん、中枢神経病変に伴う認知機能への影響 3.認知機能障害を示す様々な背景.)

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  • がんと認知機能障害 気づく,評価する,支援する

    谷向仁、華井明子、平本秀二、小川朝生、佐伯吉規、川原玲子、岡本禎晃、足立浩祥、倉田明子、岡本泰昌、奥山徹、山田了士、井上真一郎、小橋美月、松岡真里、平井啓、桜井なおみ、前田留里、小川真寛、田畑阿美、馬場千夏( Role: Joint author ,  ADHDによる認知機能への影響.)

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    山田了士( Role: Sole author ,  精神医学的面接.)

    医学書院  2020.1  ( ISBN:9784260039390

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    Responsible for pages:p1043   Language:Japanese

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  • 認知症専門医のための臨床神経病理学

    寺田整司、横田修、三木知子、竹之下慎太郎、原口俊、石津秀樹、黒田重利、山田了士( Role: Joint author ,  嗜銀顆粒病・tangle-predominant dementia・DNTC.)

    ワールドプランニング  2019.5  ( ISBN:9784863511507

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  • 認知症専門医のための臨床神経病理学

    横田修、三木知子、竹之下慎太郎、寺田整司、原口俊、石津秀樹、黒田重利、山田了士( Role: Joint author ,  進行性核上性麻痺と大脳皮質基底核変性症:精神科臨床に役立つ病理学的事項.)

    ワールドプランニング  2019.5  ( ISBN:9784863511507

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  • 非定型パーキンソニズム ?基礎と臨床-

    横田修、山田了士( Role: Joint author ,  精神症状.)

    文光堂  2019.5  ( ISBN:9784830615474

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    Responsible for pages:pp38-44   Language:Japanese

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  • 今日の治療指針2019年度版

    山田了士( Role: Sole author ,  てんかんによる精神症状.)

    医学書院  2019.1  ( ISBN:9784260036504

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    Responsible for pages:pp1029-1030   Language:Japanese

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  • 精神科研修ノート改訂第2版

    山田了士( Role: Sole author ,  入院適応の決定.)

    診断と治療社  2016.4  ( ISBN:9784787821904

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    Responsible for pages:pp166-168   Language:Japanese

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  • 先進医薬研究振興財団研究成果報告集2015年度

    岡久祐子、酒本真次、?木学、松本洋輔、山田了士( Role: Joint author ,  性同一性障害全ゲノム関連解析による病態解明.)

    先進医薬研究振興財団  2016.3 

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    Responsible for pages:pp60-61   Language:Japanese

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  • 精神保健福祉士養成講座1.精神医学

    山田了士(神経系の疾患(てんかんを含む))

    中央法規出版,東京  2002.4 

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    Responsible for pages:pp163-178  

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  • 厚生省精神・神経疾患研究委託費(10指ー1)新技術を用いたてんかん等の診断法と治療法の開発

    森本 清、 山田了士、 児玉昌純、小山文彦、和気洋介、 原 浩、平尾 徹、渡辺岳海、佐藤圭子(てんかん発作発射の薬理ー興奮性アミノ酸 AMPA 受容体拮抗薬の抗てんかん作用の多角的検討ー)

    2001.4 

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    Responsible for pages:pp17-23  

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  • 総合病院における精神医学

    *山田了士、黒田重利(一般病棟において必要な精神医学)

    中山書店  2000.4 

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    Responsible for pages:31 - 38  

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MISC

  • Ecg receptors contribute to pyramidal cell death in the mouse hippocampus following local kainic acid injection.

    Suemitsu Shunsuke, Watanabe Makiko, Yokobayashi Eriko, Usui Shinichi, Ishikawa Tetsuya, Matsumoto Yosuke, Yamada Norihito, Okamoto Motoi

    Neuroscinece   102   2955 - 2973   2090

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  • 病態に応じた周術期での注意点 3.精神疾患

    井上真一郎, 江角悟, 山本昌子, 山口恵, 廣部貴惠, 井上尚子, 神崎あかね, 横林恵理子, 千田真友子, 植田真司, 三宅俊明, 山田了士

    月刊薬事   63 ( 3 )   2021

  • 知的障害者における認知症のスクリーニング方法の検討

    竹之下慎太郎, 寺田整司, 桑野良三, 井上友和, 長壽厚志, 末光茂, 末光茂, 林聡, 三木知子, 三木知子, 横田修, 横田修, 山田了士

    老年精神医学雑誌   31   2020

  • うつ病・双極性障害~認知症との鑑別ではなく,両者の併存を前提として~

    寺田整司, 竹之下慎太郎, 三木知子, 横田修, 山田了士

    Dementia Japan   34 ( 4 )   2020

  • MIBG心筋シンチグラフィで取り込み低下を示す高齢うつ病患者の臨床的特徴

    寺田整司, 竹之下慎太郎, 大島悦子, 山口恵, 林聡, 樋之津健二, 江角悟, 新家崇義, 河野禎子, 住友佳代, 三木知子, 三木知子, 横田修, 横田修, 山田了士

    老年精神医学雑誌   31   2020

  • 老年期の精神障害と神経変性-特に加齢関連タウオパチーについて-

    横田修, 横田修, 三木知子, 三木知子, 石津秀樹, 長谷川成人, 原口俊, 寺田整司, 山田了士

    老年精神医学雑誌   31   2020

  • 精神疾患の病理;蛋白蓄積症の観点から

    横田修, 横田修, 三木知子, 三木知子, 原口俊, 石津秀樹, 長谷川成人, 寺田整司, 山田了士

    Dementia Japan   34 ( 4 )   2020

  • 相貌認知障害を呈したFTLD-FUS(好塩基性封入体病)の一例

    三木知子, 三木知子, 横田修, 横田修, 竹之下慎太郎, 石津秀樹, 黒田重利, 寺田整司, 山田了士

    老年精神医学雑誌   31   2020

  • 岡山地域における精神・神経疾患ブレインバンク:現状と展望

    横田修, 横田修, 横田修, 横田修, 三木知子, 三木知子, 三木知子, 三木知子, 原口俊, 石津秀樹, 寺田整司, 黒田重利, 黒田重利, 山田了士

    日本精神神経学会総会プログラム・抄録集   116th   2020

  • Addenbrooke’s Cognitive Examination III(ACE-III)日本語版の信頼性および妥当性の検討

    矢部真弓, 今井奈緒, 堀内真希子, 山口恵, 竹之下慎太郎, 吉田英統, 三木知子, 三木知子, 横田修, 横田修, 寺田整司, 山田了士

    老年精神医学雑誌   31   2020

  • 認知症患者の陽性感情と家族の介護負担度

    河野禎子, 寺田整司, 竹之下慎太郎, 林聡, 大島義孝, 三木知子, 横田修, 山田了士

    老年精神医学雑誌   31   2020

  • 嗜銀顆粒病と双極性障害:扁桃核におけるタウ病理の検討

    三木知子, 三木知子, 横田修, 横田修, 石津秀樹, 上野修一, 竹之下慎太郎, 寺田整司, 山田了士

    Dementia Japan   34 ( 4 )   2020

  • 老年精神医学分野の疾患における画像診断のいまとこれから 遅発性統合失調症・妄想性障害再考-分子神経病理学からの提言- Invited

    横田修, 三木知子, 池田智香子, 原口俊, 石津秀樹, 寺田整司, 山田了士

    老年精神医学雑誌   31 ( 3 )   276 - 289   2020

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    J-GLOBAL

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  • Argyrophiic grain disease(AGD)の臨床病理

    横田修, 横田修, 三木知子, 三木知子, 原口俊, 石津秀樹, 長谷川成人, 寺田整司, 山田了士

    Dementia Japan   34 ( 4 )   2020

  • 認知症患者の陽性感情と介護負担度との関係

    河野禎子, 寺田整司, 竹之下慎太郎, 林聡, 大島義孝, 三木知子, 三木知子, 横田修, 横田修, 山田了士

    Dementia Japan   34 ( 4 )   2020

  • 「精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築」精神科臨床場面における多職種協働による効果的ながん検診の受診勧奨法の開発と効果を検証する研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 樋之津史郎, 藤原雅樹, 堀井茂男, 児玉匡史, 宮路天平, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 岡田裕之, 原田馨太, 黒崎美雪

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 令和元年度 総括・分担研究報告書(Web)   2020

  • 「精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築」精神障害者のがん診断と治療における課題を明らかにし,問題を解決するための連携を促進する体制構築を目指す研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 井上真一郎, 和田里穂, 江藤剛

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 令和元年度 総括・分担研究報告書(Web)   2020

  • アルツハイマー型認知症における脳血流低下と心の理論の関係

    竹之下慎太郎, 寺田整司, 林聡, 河野禎子, 住友佳代, 三木知子, 三木知子, 横田修, 横田修, 山田了士

    Dementia Japan   34 ( 4 )   2020

  • 精神科病院に通院中の統合失調症患者の禁煙ステージとその後の禁煙行動 アンケートによる縦断調査

    藤原 雅樹, 樋口 裕二, 稲垣 正俊, 中谷 直樹, 藤森 麻衣子, 林原 千夏, 宋 龍平, 新川 郁太, 佐藤 康治郎, 矢田 勇慈, 児玉 匡史, 竹中 央, 来住 由樹, 掛田 恭子, 内富 庸介, 山田 了士

    精神神経学雑誌   ( 2019特別号 )   S436 - S436   2019.6

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    Language:Japanese   Publisher:(公社)日本精神神経学会  

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  • 認知症患者の客観的QOL評価は、主観的QOLをどのように反映しているのか

    竹之下 慎太郎, 寺田 整司, 山口 晴保, 山田 了士

    認知症ケア研究誌   3   38 - 44   2019

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    Language:Japanese   Publisher:認知症介護研究・研修センター  

    【目的】認知症患者を対象とした客観的なquality of life(QOL)評価票は数多く開発されている。ただ、それらの評価票が、認知症患者の主観的QOLを、どのように反映しているのかはほとんど検討されていない。本報告では、客観的QOL評価票として日本で開発されたshort version of quality of lifequestionnaire for dementia(short QOL-D)について、主観的QOLとの関係を検討した。【方法】大学病院の物忘れ外来を受診した患者を対象とした。主観的QOLを評価するWorld HealthOrganization quality of life-BREF 26 questionnaire(WHOQOL-BREF26)を本人が記入し、客観的QOLを評価するshort QOL-Dを介護者が評価した。加えて、患者の年齢、性別、診断が記録され、clinical dementia rating(CDR)、Mini-mental state examination(MMSE)、NeuropsychiatricInventory(NPI)、Functional activities questionnaire(FAQ)が評価された。【結果】正常認知群45人、軽度認知障害群103人、認知症群(CDR0.5または1)105人が対象とされた。回帰分析の結果から、short QOL-Dの全項目の平均得点は、NPI得点・WHOQOL-BREF26全項目の平均得点と有意に関連していた。陽性領域の平均得点はWHOQOL-BREF26全項目の平均得点・NPI得点と、陰性領域の平均得点はNPI得点と関連していた。【結論】客観的QOL評価であるshort QOL-Dのうち、陽性領域は主観的QOLとBehavioral andpsychological symptoms of dementia(BPSD)を反映し、陰性領域はBPSDの中でも本人が自覚しにくい症状(易刺激性、興奮)を反映していた。認知症においては、主観的QOLに加えて、客観的QOLを評価することに積極的な意味があると考える。(著者抄録)

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  • 中心静脈栄養中に黄色ブドウ球菌による血流感染を生じた神経性無食欲症の2例

    山田裕士, 山田裕士, 藤原雅樹, 千田真友子, 溝渕真衣子, 酒本真次, 徳増一樹, 萩谷英大, 山田了士

    総合病院精神医学   31 ( Supplement )   2019

  • 広範なTDP-43陽性病変と軽度のPSP類似病理を伴った嗜銀顆粒病-多動,常同的な言語反復,認知機能低下を呈した一剖検例-

    三木知子, 三木知子, 横田修, 横田修, 安田華枝, 竹之下慎太郎, 石津秀樹, 黒田重利, 寺田整司, 山田了士

    老年精神医学雑誌   30   2019

  • 不安,心気,うつ,常同的言語反復,認知症を呈した嗜銀顆粒病

    三木知子, 三木知子, 横田修, 横田修, 横田修, 池田智香子, 石津秀樹, 黒田重利, 竹之下慎太郎, 寺田整司, 山田了士

    Dementia Japan   33 ( 4 )   2019

  • 神経変性と精神疾患

    横田修, 横田修, 三木知子, 石塚秀樹, 原口俊, 寺田整司, 山田了士

    総合病院精神医学   31 ( Supplement )   2019

  • 知的障害者における認知症の疫学研究,スクリーニング検査の作成

    竹之下慎太郎, 寺田整司, 桑野良三, 井上友和, 長壽厚志, 末光茂, 末光茂, 林聡, 三木知子, 三木知子, 横田修, 横田修, 山田了士

    Dementia Japan   33 ( 4 )   2019

  • 精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 精神科臨床場面における多職種協働による効果的ながん検診の受診勧奨法の開発と効果を検証する研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 樋之津史郎, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 宮路天平, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 岡田裕之, 原田馨太

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 平成30年度 総括・分担研究報告書(Web)   2019

  • 精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 精神障害者のがん診断と治療における課題を明らかにし,問題を解決するための連携を促進する体制構築を目指す研究

    稲垣正俊, 山田了士, 内富庸介, 藤森麻衣子, 藤原雅樹, 堀井茂男, 児玉匡史, 島津太一, 高橋宏和, 中谷直樹, 森田達也, 松下貴紀, 吉村優作, 宋龍平, 掛田恭子, 樋口裕二, 山田裕士, 井上真一郎

    精神障害患者の低いがん検診受診率を向上させる勧奨法の開発および標準的ながん治療・ケアへのアクセスを改善するための課題の把握と連携を促進する仕組みの構築 平成30年度 総括・分担研究報告書(Web)   2019

  • 岡山県の知的障害者施設における認知症の有病率調査

    竹之下慎太郎, 寺田整司, 桑野良三, 井上友和, 長壽厚志, 末光茂, 林聡, 三木知子, 横田修, 山田了士

    老年精神医学雑誌   30   2019

  • Addenbrooke’s Cognitive Examination III日本語版の信頼性・妥当性の検討

    矢部真弓, 今井奈緒, 堀内真希子, 山口恵, 竹之下慎太郎, 吉田英統, 三木知子, 三木知子, 横田修, 横田修, 寺田整司, 山田了士

    Dementia Japan   33 ( 4 )   2019

  • bvFTDの縦断的臨床像と病理背景

    横田修, 三木知子, 三木知子, 石津秀樹, 寺田整司, 山田了士

    Dementia Japan   33 ( 4 )   2019

  • 老年精神医学分野におけるさまざまなタイプの認知症研究を読み解く 海外の認知機能検査の日本語版作成研究の要点-ACE-III日本語版標準化を例にして-

    竹之下慎太郎, 寺田整司, 三木知子, 横田修, 山田了士

    老年精神医学雑誌   30 ( 7 )   2019

  • 行動異常型前頭側頭型認知症

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    老年精神医学雑誌   29   2018

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