2021/07/12 更新

写真a

ツダ トシヒデ
津田 敏秀
TSUDA Toshihide
所属
環境生命科学学域 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 根拠に基づく医学

  • 因果推論

  • Environmental Medicine

  • Epidemiology

  • 環境医学

  • 疫学

  • Evidence Based Medicine

  • Causal Inference

研究分野

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含む

  • ライフサイエンス / 医療管理学、医療系社会学

  • 環境・農学 / 環境政策、環境配慮型社会

  • 環境・農学 / 環境影響評価

  • 人文・社会 / 哲学、倫理学

  • ライフサイエンス / 衛生学、公衆衛生学分野:実験系を含まない

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学歴

  • 岡山大学   Graduate School, Division of Medicine   Department of Hygiene

    - 1989年

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  • 岡山大学    

    - 1989年

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    国名: 日本国

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  • 岡山大学   医学部   医学科

    - 1985年

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    国名: 日本国

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  • 岡山大学   Faculty of Medicine   School of Medicine

    - 1985年

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経歴

  • - 岡山大学 大学院環境学研究科 教授

    2005年

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  • - 岡山大学本部安全衛生委員会 産業医

    2005年

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  • - 岡山大学環境生命科学研究科 教授

    2005年

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  • - Professor,Okayama University The Graduate School of Environmental Science

    2005年

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  • - Professor,Graduate School of Environmental and life Science,Okayama University

    2005年

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  • - Occupational Physician,Occupational Safety and Health,Administrative Center,Okayama University

    2005年

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  • - 岡山大学岡山大学病院治験審査委員会 治験審査委員

    2004年

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  • - Comittee Member of IRB,Institutional Review Board,University Hospital of Medicine and Dentistry,Okayama University

    2004年

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  • Professor,Department of Hygiene, Okayama University Graduate School of Medical and Dental Science

    2001年 - 2004年

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  • 岡山大学大学院医歯学総合研究科長寿社会医学専攻衛生学 教授

    2001年 - 2004年

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  • Senior Assistant Professor,Department of Hygiene, Okayama University School of Medicine

    1995年 - 2001年

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  • 岡山大学医学部衛生学教室 講師   Medical School

    1995年 - 2001年

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  • Assistant Professor,Okayama University School of Medicine

    1990年 - 1995年

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  • 岡山大学医学部 助教   Medical School

    1990年 - 1995年

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所属学協会

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委員歴

  • 日本公衆衛生学会   評議員  

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    団体区分:学協会

    日本公衆衛生学会

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  • 日本衛生学会   評議員  

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    団体区分:学協会

    日本衛生学会

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書籍等出版物

  • 医学者は公害事件で何をしてきたのか

    岩波書店(岩波現代文庫)  2014年  ( ISBN:9784006003111

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  • 医学的根拠とは何か

    岩波書店(岩波新書)  2013年 

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  • Training Program on Food-Borne Disease Epidemiology

    Japan Food Hygiene Association  2012年 

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  • 食中毒の疫学講座.

    日本食品衛生協会  2012年 

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  • Medicine and Hypothesis -Science on cause and outcome-

    Iwanami co. Ltd.  2011年 

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  • 新通史 日本の科学技術 第4巻: 世紀転換期の社会史/1995年~2011年

    原書房  2011年 

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  • 医学と仮説-原因と結果の科学を考える-

    岩波書店  2011年 

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  • The Science and Tchnology in Japan

    2011年 

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  • 津田敏秀レビューアーの意見書と著者らの対応

    丸善  2009年 

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  • 医学における因果関係の推論と原因確率.法と経済学叢書 Ⅷ〕サナ・ルー著 『法,疫学,市民社会:法政策における科学的手法の活用』

    木鐸社  2009年 

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  • アスベストによる健康障害の疫学とリスクアセスメント―特に環境曝露による人体への影響に関して―.解説資料:石綿関係法施行状況調査.

    衆議院調査局環境調査室  2008年 

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  • 平成17年度厚生労働科学研究費補助金(食品の安心・安全確保研究事業)食品の安全施策等に関する国際協調のあり方に関する研究、研究報告書

    2007年 

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  • カネミ油症-過去・現在・未来-.

    緑風出版  2006年 

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  • 悪魔のマーケティング-タバコ産業の真実-

    日経BP社  2005年 

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  • 水俣学講義 第2集

    日本評論社  2005年 

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  • 悪魔のマーケティング-タバコ産業が語った真実-

    日経BP社  2005年 

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  • 医学者は公害事件で何をしてきたのか

    岩波書店  2004年 

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  • 厚生労働科学研究研究費補助金、長寿科学総合研究事業研究報告書「老人疾患患者に及ぼす家族の感情表出の影響に関する研究」

    2003年 

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  • 厚生労働科学研究研究費補助金、新興再興感染症研究事業研究報告書「経口細菌感染症の広域的・散発的発生時の実地疫学的・調査手法等の開発に関する研究」

    2003年 

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  • 医学大事典

    医学書院,東京  2003年 

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  • 市民のための疫学入門-医学ニュースから環境裁判まで-.

    緑風出版,東京  2003年 

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  • 交代勤務と心血管系疾患メカニズムのレビュー.

    自治体労働安全衛生研究会  2002年 

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  • 讀賣新聞

    2001年 

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  • 毎日新聞

    2001年 

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  • 筋骨格性障害と職場要因?アメリカ労働安全衛生研究所による腰部における職業関連性による筋骨格性障害に関する疫学的レビュー?

    2001年 

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  • Chapter 15 Epidemiological Studies of Cancer in Arsenic Poisoning Patients

    Encyclopedis of Environmental Control Technology, Volume 7 High-Hazard Pollutants 

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  • Chapter 15 Epidemiological Studies of Cancer in Arsenic Poisoning Patients

    Encyclopedis of Environmental Control Technology, Volume 7 High-Hazard Pollutants 

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MISC

  • Is there an obesity paradox in the Japanese elderly population? A community-based cohort study of 13 280 men and women

    Kenji Yamazaki, Etsuji Suzuki, Takashi Yorifuji, Toshihide Tsuda, Toshiki Ohta, Kazuko Ishikawa-Takata, Hiroyuki Doi

    GERIATRICS & GERONTOLOGY INTERNATIONAL   17 ( 9 )   1257 - 1264   2017年9月

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    記述言語:英語   出版者・発行元:WILEY  

    AimDespite increased interest in an obesity paradox (i.e. a survival advantage of being obese), evidence remains sparse in Japanese populations. We aimed to verify this phenomenon among community-dwelling older adults in Japan.
    MethodsOlder adults aged 65-84 years randomly chosen from all 74 municipalities in Shizuoka Prefecture completed questionnaires including body mass index information. Participants were followed from 1999 to 2009. Following World Health Organization guidelines, participants were classified using an appropriate body mass index for Asian populations as follows: <18.5 kg/m(2) (underweight), 18.5-23.0 kg/m(2) (normal weight), 23.0-27.5 kg/m(2) (overweight) and 27.5 kg/m(2) (obesity). We estimated hazard ratios and their 95% confidence intervals for all-cause mortality, controlling for sex, age, smoking status, alcohol consumption, physical activity, hypertension and diabetes mellitus.
    ResultsCompared with normal-weight participants, overweight/obese participants tended to have lower hazard ratios; the multivariate hazard ratios (95% confidence interval) were 0.86 (0.62-1.19) for obesity, 0.83 (0.73-0.94) for overweight and 1.60 (1.40-1.82) for underweight. In subgroup analyses by sex and age, the hazard ratios tended to be lower among obese men, albeit not significantly; hazard ratios (95% confidence interval) were 0.56 (0.25-1.27) in men aged 65-74 years, and 0.78 (0.41-1.45) in men aged 75-84 years.
    ConclusionsThe present study provides evidence of a conservative obesity paradox among older Japanese people, using the appropriate body mass index cut-off points for Asian populations. In particular, obese older men tend to have a lower risk of all-cause mortality. Geriatr Gerontol Int 2017; 17: 1257-1264.

    DOI: 10.1111/ggi.12851

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  • Correlation between infectious disease and soil radiation in Japan: an exploratory study using national sentinel surveillance data

    S. Inaida, T. Tsuda, S. Matsuno

    EPIDEMIOLOGY AND INFECTION   145 ( 6 )   1183 - 1192   2017年4月

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    記述言語:英語   出版者・発行元:CAMBRIDGE UNIV PRESS  

    We investigated the relationship between epidemics and soil radiation through an exploratory study using sentinel surveillance data (individuals aged <20 years) during the last three epidemic seasons of influenza and norovirus in Japan. We used a spatial analysis method of a geographical information system (GIS). We mapped the epidemic spreading patterns from sentinel incidence rates. We calculated the average soil radiation [dm (mu Gy/h)] for each sentinel site using data on uranium, thorium, and potassium oxide in the soil and examined the incidence rate in units of 0.01 mu Gy/h. The correlations between the incidence rate and the average soil radiation were assessed. Epidemic clusters of influenza and norovirus infections were observed in areas with relatively high radiation exposure. A positive correlation was detected between the average incidence rate and radiation dose, at r = 0.61-0.84 (P <0.01) for influenza infections and r = 0.61-0.72 (P <0.01) for norovirus infections. An increase in the incidence rate was found between areas with radiation exposure of 0 <dm <0.01 and 0.154dm <0.16, at 1.80 [95% confidence interval (CI) 1.47-2.12] times higher for influenza infection and 2.07 (95% CI 1.53-2.61) times higher for norovirus infection. Our results suggest a potential association between decreased immunity and irradiation because of soil radiation. Further studies on immunity in these epidemic-prone areas are desirable.

    DOI: 10.1017/S0950268816003034

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  • Covariate balance for no confounding in the sufficient-cause model

    Etsuji Suzuki, Toshihide Tsuda, Eiji Yamamoto

    Annals of Epidemiology   111 - 113   2017年

  • Evaluating the Effects of Air Pollution from a Plastic Recycling Facility on the Health of Nearby Residents

    Xin Zhao, Toshihide Tsuda, Hiroyuki Doi

    ACTA MEDICA OKAYAMA   71 ( 3 )   209 - 217   2017年

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We evaluated how exposure to airborne volatile organic compounds emitted from a plastic recycling facility affected nearby residents, in a cross-sectional study. Individuals> 10 years old were randomly sampled from 50 households at five sites and given questionnaires to complete. We categorized the subjects by distance from the recycling facility and used this as a proxy measure for pollutant exposure. We sought to improve on a preceding study by generating new findings, improving methods for questionnaire distribution and collection, and refining site selection. We calculated the odds of residents living 500 or 900 m away from the facility reporting mucocutaneous and respiratory symptoms using a reference group of residents 2,800 m away. Self-reported nasal congestion (odds ratio=3.0, 95% confidence interval=1.02-8.8), eczema (5.1, 1.1-22.9), and sore throat (3.9, 1.1-14.1) were significantly higher among residents 500 m from the facility. Those 900 m away were also considerably more likely to report experiencing eczema (4.6, 1.4-14.9). Air pollution was found responsible for significantly increased reports of mucocutaneous and respiratory symptoms among nearby residents. Our findings confirm the effects of pollutants emitted from recycling facilities on residents' health and clarify that study design differences did not affect the results.

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  • Thyroid Cancer Detection by Ultrasound Among Residents Ages 18 Years and Younger in Fukushima, Japan: 2011 to 2014

    Toshihide Tsuda, Akiko Tokinobu, Eiji Yamamoto, Etsuji Suzuki

    EPIDEMIOLOGY   27 ( 3 )   316 - 322   2016年5月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: After the Great East Japan Earthquake and Tsunami in March 2011, radioactive elements were released from the Fukushima Daiichi Nuclear Power Plant. Based on prior knowledge, concern emerged about whether an increased incidence of thyroid cancer among exposed residents would occur as a result.
    Methods: After the release, Fukushima Prefecture performed ultrasound thyroid screening on all residents ages 18 years. The first round of screening included 298,577 examinees, and a second round began in April 2014. We analyzed the prefecture results from the first and second round up to December 31, 2014, in comparison with the Japanese annual incidence and the incidence within a reference area in Fukushima Prefecture.
    Results: The highest incidence rate ratio, using a latency period of 4 years, was observed in the central middle district of the prefecture compared with the Japanese annual incidence (incidence rate ratio = 50; 95% confidence interval [CI] = 25, 90). The prevalence of thyroid cancer was 605 per million examinees (95% CI = 302, 1,082) and the prevalence odds ratio compared with the reference district in Fukushima Prefecture was 2.6 (95% CI = 0.99, 7.0). In the second screening round, even under the assumption that the rest of examinees were disease free, an incidence rate ratio of 12 has already been observed (95% CI = 5.1, 23).
    Conclusions: An excess of thyroid cancer has been detected by ultrasound among children and adolescents in Fukushima Prefecture within 4 years of the release, and is unlikely to be explained by a screening surge.

    DOI: 10.1097/EDE.0000000000000385

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  • Effects of Ayurvedic Oil-Dripping Treatment with Sesame Oil vs. with Warm Water on Sleep: A Randomized Single-Blinded Crossover Pilot Study

    Akiko Tokinobu, Takashi Yorifuji, Toshihide Tsuda, Hiroyuki Doi

    JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE   22 ( 1 )   52 - 58   2016年1月

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    記述言語:英語   出版者・発行元:MARY ANN LIEBERT, INC  

    Objectives: Ayurvedic oil-dripping treatment (Shirodhara) is often used for treating sleep problems. However, few properly designed studies have been conducted, and the quantitative effect of Shirodhara is unclear. This study sought to quantitatively evaluate the effect of sesame oil Shirodhara (SOS) against warm water Shirodhara (WWS) on improving sleep quality and quality of life (QOL) among persons reporting sleep problems. Methods: This randomized, single-blinded, crossover study recruited 20 participants. Each participant received seven 30-minute sessions within 2 weeks with either liquid. The washout period was at least 2 months. The Shirodhara procedure was conducted by a robotic oil-drip system. The outcomes were assessed by the Pittsburgh Sleep Quality Index (PSQI) for sleep quality, Epworth Sleepiness Scale (ESS) for daytime sleepiness, World Health Organization Quality of Life 26 (WHO-QOL26) for QOL, and a sleep monitor instrument for objective sleep measures. Changes between baseline and follow-up periods were compared between the two types of Shirodhara. Analysis was performed with generalized estimating equations. Results: Of 20 participants, 15 completed the study. SOS improved sleep quality, as measured by PSQI. The SOS score was 1.83 points lower (95% confidence interval [CI], -3.37 to -0.30) at 2-week follow-up and 1.73 points lower (95% CI, -3.84 to 0.38) than WWS at 6-week follow-up. Although marginally significant, SOS also improved QOL by 0.22 points at 2-week follow-up and 0.19 points at 6-week follow-up compared with WWS. After SOS, no beneficial effects were observed on daytime sleepiness or objective sleep measures. Conclusions: This pilot study demonstrated that SOS may be a safe potential treatment to improve sleep quality and QOL in persons with sleep problems.

    DOI: 10.1089/acm.2015.0018

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  • Maternal smoking location at home and hospitalization for respiratory tract infections among children in Japan

    Michiyo Yamakawa, Takashi Yorifuji, Tsuguhiko Kato, Toshihide Tsuda, Hiroyuki Doi

    Archives of Environmental and Occupational Health, Archives of Environmental Health, A. M. A. archives of industrial health, A. M. A. archives of industrial hygiene and occupational medicine, Archives of industrial hygiene and occupational medicine, Th・・・   1 - 8   2016年

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    Archives of Environmental and Occupational Health, Archives of Environmental Health, A. M. A. archives of industrial health, A. M. A. archives of industrial hygiene and occupational medicine, Archives of industrial hygiene and occupational medicine, The Journal of industrial hygiene and toxicology

    DOI: 10.1080/19338244.2016.1255582

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  • Aflatoxins in rice artificially contaminated with aflatoxinproducing Aspergillus flavus under natural storage in Japan

    Satoshi Sugihara, Hiroyuki Doi, Masahiko Kato, Yoshihiro Mitoh, Toshihide Tsuda, Satoru Ikeda

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama   70 ( 3 )   167 - 174   2016年

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  • Errors in causal inference

    Etsuji Suzuki, Toshihide Tsuda, Toshiharu Mitsuhashi, Mohammad Ali Mansournia, Eiji Yamamoto

    Annals of Epidemiology   26 ( 11 )   788-793.e1   2016年

  • Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan

    Takashi Yorifuji, Toshihide Tsuda

    Archives of Environmental and Occupational Health, Archives of Environmental Health, A. M. A. archives of industrial health, A. M. A. archives of industrial hygiene and occupational medicine, Archives of industrial hygiene and occupational medicine, Th・・・   1 - 6   2016年

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    Archives of Environmental and Occupational Health, Archives of Environmental Health, A. M. A. archives of industrial health, A. M. A. archives of industrial hygiene and occupational medicine, Archives of industrial hygiene and occupational medicine, The Journal of industrial hygiene and toxicology

    DOI: 10.1080/19338244.2015.1084261

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  • The authors respond

    Toshihide Tsuda, Akiko Tokinobu, Eiji Yamamoto, Etsuji Suzuki

    Epidemiology   27 ( 3 )   e21-e23   2016年

  • Frequency of Antenatal Care Visits and Neonatal Mortality in Indonesia

    Juliani Ibrahim, Takashi Yorifuji, Toshihide Tsuda, Saori Kashima, Hiroyuki Doi

    JOURNAL OF TROPICAL PEDIATRICS   58 ( 3 )   184 - 188   2012年6月

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    記述言語:英語   出版者・発行元:OXFORD UNIV PRESS  

    Objective: To examine the relationship between frequency of antenatal care visits, as a whole and in each trimester, and neonatal mortality in Indonesia. Subjects: 13 055 single births from the fifth Indonesia Demographic Health Survey in 2006-07. Methods: Estimate adjusted odds ratios (ORs) and their 95% confidence intervals (95% CIs). Results: Pregnant women who had more antenatal care visits experienced a lower risk of neonatal mortality and more benefit in the last trimester: the ORs against the 0-1 visit group, were 0.76 (95% CI 0.45-1.29) for 2 visits group, 0.54 (95% CI 0.33-0.87) for 3 visits group and 0.31 (95% CI 0.17-0.57) for 4 visits group, respectively. Individual ORs as a whole period were not significant, but ORs declined markedly at 7 visits or more. Conclusion: The results may provide a valuable recommendation for the care of pregnant women in Indonesia.

    DOI: 10.1093/tropej/fmr067

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  • On the relations between excess fraction,

    American Journal of Epidemiology   175 ( 6 )   567-575.   2012年

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  • 肺と心臓の共通の敵,タバコの害について識る.

    Heart View   16 ( 3 )   58(266)-63(271)   2012年

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  • Does open-air exposure to volatile organic compounds near a plastic recycling factory cause health effects?

    Journal of Occupational Health   54   79 - 87   2012年

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  • Adverse effects of cigarette smoking - The common enemy against lung and heart in humans.

    16 ( 3 )   58(266)-63(271)   2012年

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  • Acute non-cancer mortality excess after polychlorinated biphenyls and polychlorinated dibenzofurans mixed exposure from contaminated rice oil: Yusho

    Saori Kashima, Takashi Yorifuji, Toshihide Tsuda

    SCIENCE OF THE TOTAL ENVIRONMENT   409 ( 18 )   3288 - 3294   2011年8月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    In Japan in 1968, rice-oil contaminated by polychlorinated biphenyls and polychlorinated dibenzofurans caused severe food poisoning, termed "Yusho" (oil disease). Several previous studies attempted to evaluate the effects targeting officially-certified Yusho patients. However, these studies have several limitations such as the left-truncated nature of the registry or residual confounding arising from the referent population selection. We thus conducted an area-based standardized mortality ratios (SMRs) study using vital statistics. A severely affected area (Tamanoura area) was adopted as the exposure group, with a reference population from Nagasaki prefecture in Kyushu, which included the Tamanoura. A large number of residents in Tamanoura were exposed to the rice-oil (28% of all the certified cases as of 2009). We estimated SMRs of non-cancer and cancer diseases for the years 1968-2002. Shortly after the exposure, SMRs of all causes, diabetes mellitus, cardiovascular disease, pneumonia/bronchitis, and bronchus/lung cancer were elevated. In particular, SMRs of heart disease were 1.97 [95% confidence intervals (CI): 1.09-3.56] in 1968, 2.05 (95% Cl: 1.16-3.60) in 1969, and 1.89 (95% CI: 1.05-3.41) in 1975. However, we did not observe clear increase in SMRs more than 10 years after the exposure. This study provides further evidence in Yusho, especially on acute effects on non-cancer mortality. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.scitotenv.2011.05.038

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  • Environmental Health Research Implications of Methylmercury

    Toshihide Tsuda, Takashi Yorifuji, Masazumi Harada

    ENVIRONMENTAL HEALTH PERSPECTIVES   119 ( 7 )   A284 - A284   2011年7月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE  

    DOI: 10.1289/ehp.1103580

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  • Residential proximity to heavy traffic and birth weight in Shizuoka, Japan

    Saori Kashima, Hiroo Naruse, Takashi Yorifuji, Shigeru Ohki, Takeshi Murakoshi, Soshi Takao, Toshihide Tsuda, Hiroyuki Doi

    ENVIRONMENTAL RESEARCH   111 ( 3 )   377 - 387   2011年4月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    An association between exposure to traffic-related air pollution and reduced birth weight has been suggested. However, previous studies have failed to adjust for maternal size, which is an indicator of individual genetic growth potential. Therefore, we evaluated the association of air pollution with birth weight, term low birth weight (term-LBW), and small for gestational age (SGA), with adjustment for maternal size. Individual data were extracted from a database that is maintained by a maternal and perinatal care center in Shizuoka, japan. We identified liveborn singleton births (n=14,204). Using geocoded residential information, each birth was assigned a number of traffic-based exposure indicators: distance to a major road; distance-weighted traffic density; and estimated concentration of nitrogen dioxide by land use regression. The multivariate adjusted odds ratios and their 95% confidence intervals (CIs) for the associations between exposure indicators and outcomes were then estimated using logistic regression models. Overall, exposure indicators of air pollution showed no clear pattern of association. Although there are many limitations, we did not find clear associations between birth-weight-related outcomes and the three markers of traffic-related air pollution. (C) 2011 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.envres.2011.02.005

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  • Identification of operating mediation and mechanism in the sufficient-component cause framework.

    Eur J Epidemiol.   26 ( 5 )   347 - 357   2011年

  • Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan

    Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Hiroyuki Doi, Masumi Sugiyama, Kazuko Ishikawa-Takata, Toshiki Ohta

    OCCUPATIONAL AND ENVIRONMENTAL MEDICINE   67 ( 2 )   111 - 117   2010年2月

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    記述言語:英語   出版者・発行元:B M J PUBLISHING GROUP  

    Objectives The number of studies investigating the health effects of long-term exposure to air pollution is increasing, however, most studies have been conducted in Western countries. The health status of Asian populations may be different to that of Western populations and may, therefore, respond differently to air pollution exposure. Therefore, we evaluated the health effects of long-term exposure to traffic-related air pollution in Shizuoka, Japan.
    Methods Individual data were extracted from participants of an ongoing cohort study. A total of 14 001 older residents, who were randomly chosen from all 74 municipalities of Shizuoka, completed questionnaires and were followed from December 1999 to March 2006. Individual nitrogen dioxide exposure data, as an index for traffic-related exposure, were modelled using a land use regression model. We assigned participants an estimated concentration of nitrogen dioxide exposure during 2000-2006. We then estimated the adjusted HR and their Cl for a 10 mu g/m(3) increase in exposure to nitrogen dioxide for all-cause or cause-specific mortality.
    Results The adjusted HR for all-cause mortality was 1.02 (95% Cl 0.96 to 1.08). Regarding cause-specific mortality, the adjusted HR for cardiopulmonary mortality was 1.16 (95% Cl 1.06 to 1.26); in particular the adjusted HR for ischaemic heart disease mortality was 1.27 (95% Cl 1.02 to 1.58) and for pulmonary disease mortality it was 1.19 (95% Cl 1.02 to 1.38). Furthermore, among non-smokers, a 10 mu g/m(3) increase in nitrogen dioxide was associated with a higher risk for lung cancer mortality (HR 1.30, 95% Cl 0.85 to 1.93).
    Conclusion Long-term exposure to traffic-related air pollution, indexed by nitrogen dioxide concentration, increases the risk of cardiopulmonary mortality, even in a population with a relatively low body mass index and increases the risk of lung cancer mortality in nonsmokers.

    DOI: 10.1136/oem.2008.045542

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  • Training Program on Food-Borne Disease Epidemiology 17. Bias in Epidemiology: Type, Magnitude, Direction, and its Countermeasure

    Food Sanitation Research   60 ( 2 )   39 - 46   2010年

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  • Training Program on Food-Borne Disease Epidemiology 16. Bias in Epidemiology: Type, Magnitude, Direction, and its Countermeasure The First Part

    Food Sanitation Research   60 ( 1 )   47 - 55   2010年

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  • Training Program on Food-Borne Disease Epidemiology 20. Descriptive Epidemiology and Geographic Information Systems (GIS)

    Food Sanitation Research   60 ( 5 )   47 - 56   2010年

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  • 食中毒の疫学研修講座18.食中毒の「原因」と回収問題.食品衛生研究2010;60(3):37-46.

    食品衛生研究   60 ( 3 )   37 - 46   2010年

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  • 食中毒の疫学研修講座17.疫学研究におけるバイアスの種類、その影響の程度と方向、およびその対策:後編.

    食品衛生研究   60 ( 2 )   39 - 46   2010年

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  • 食中毒の疫学研修講座16.疫学研究におけるバイアスの種類、その影響の程度と方向、およびその対策:前編.

    食品衛生研究   60 ( 1 )   47 - 55   2010年

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  • Training Program on Food-Borne Disease Epidemiology 21: Closing Remarks on the Serial

    Food Sanitation Research   60 ( 6 )   33 - 44   2010年

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  • 食中毒の疫学研修講座21.連載を終わるにあたって.食品衛生研究2010;60(6):33-44.

    食品衛生研究   60 ( 6 )   33 - 44   2010年

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  • 記述疫学と地理情報システム

    食品衛生研究   60 ( 5 )   47 - 56   2010年

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  • 食中毒の疫学研修講座19.古典的調査法では対応できない広域散発事例.

    食品衛生研究   60 ( 4 )   29 - 38   2010年

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  • Training Program on Food-Borne Disease Epidemiology 18. "Cause" of Food Borne Disease and Recall

    Food Sanitation Research   60 ( 3 )   37 - 46   2010年

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  • Training Program on Food-Borne Disease Epidemiology 19. Case-Control Study (3). Multi-Prefectural Disease Outbreaks which are Difficult to be Investigated by a Classical Method

    Food Sanitation Research   60 ( 4 )   29 - 38   2010年

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  • What has methylmercury in umbilical cords told us? - Minamata disease

    Takashi Yorifuji, Saori Kashima, Toshihide Tsuda, Masazumi Harada

    SCIENCE OF THE TOTAL ENVIRONMENT   408 ( 2 )   272 - 276   2009年12月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Severe methylmercury poisoning occurred in Minamata and neighboring communities in the 1950s and 1960s. The exposed patients manifested neurological signs, and some patients exposed in utero were born with so-called congenital Minamata disease. In a previous report, Nishigaki and Harada evaluated the methylmercury concentrations in the umbilical cords of inhabitants and demonstrated that methylmercury actually passed through the placenta (Nishigaki and Harada, 1975). However, the report involved a limited number of cases (only 35) and did not quantitatively evaluate the regional differences in the transition of methylmercury exposure. Therefore, in the present study, we evaluated the temporal and spatial distributions of methylmercury concentrations in umbilical cords, with an increased number of participants and additional descriptive analyses. Then, we examined whether the methylmercury concentrations corresponded with the history of the Minamata disease incident. A total of 278 umbilical cord specimens collected after birth were obtained from babies born between 1925 and 1980 in four study areas exposed to methylmercury. Then. we conducted descriptive analyses, and drew scatterplots of the methylmercury concentrations of all the participants and separated by the areas. In the Minamata area, where the first patient was identified in 1956, the methylmercury concentration reached a peak around 1955. Subsequently, about 5 years later, the concentrations peaked in other exposed areas with the expected exposure distribution corresponding with acetaldehyde production (the origin of methylmercury). This historical incident several decades ago in Minamata and neighboring communities clearly shows that regional pollution affected the environment in utero. Furthermore, the temporal and spatial distributions of the methylmercury concentrations in the umbilical cords tell us the history of the Minamata disease incident. (C) 2009 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.scitotenv.2009.10.011

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  • Oseltamivir and Abnormal Behaviors True or Not?

    Takashi Yorifuji, Etsuji Suzuki, Toshihide Tsuda

    EPIDEMIOLOGY   20 ( 4 )   619 - 621   2009年7月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Oseltamivir is a neuraminidase inhibitor that inhibits influenza virus proliferation, and is used as an antiviral drug against influenza A and B viruses. Recently, concerns have been raised about hallucinations, delirium, and abnormal activity after administration of oseltamivir for treatment of infection with influenza virus. A large epidemiologic study was conducted in Japan in the winter of 2006-2007 to assess the relationship between oseltamivir intake and adverse behaviors, and an interim report was released on 10 July 2008. In the report, the research group concluded that no positive associations were detected between oseltamivir intake and abnormal behaviors. However, the analytic method used in the study was flawed. A correct analysis (based on person-time) shows a rate ratio of 1.57 (95% confidence interval = 1.34-1.83). This example clearly illustrates the importance of person-time in the analysis of cohort studies.

    DOI: 10.1097/EDE.0b013e3181a3d3f6

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  • Minamata Disease. –A catastrophic poisoning due to failure of appropriate public health response.

    Tsuda Toshihide, Yorifuji Takashi, Takao Soshi, Miyai Masaya, Babazono Akira

    Journal of Public Health Policy   30 ( 1 )   54 - 67   2009年4月

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  • Minamata disease: Catastrophic poisoning due to a failed public health response

    Toshihide Tsuda, Takashi Yorifuji, Soshi Takao, Masaya Miyai, Akira Babazono

    Journal of Public Health Policy   30 ( 1 )   54 - 67   2009年4月

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    記述言語:英語  

    We present the history of Minamata disease in a chronological order from the public health point of view. Because the appropriate public health response - to investigate and control the outbreak - as set out in the Food Sanitation Act was not conducted, no one knew how many became ill following the outbreak. Exposure could not be stopped. In our discussion, we offer two reasons as to why the Japanese public health agencies did not apply the Act: social circumstances in the 1950s and 1960s that placed emphasis on industrial development, and the Japanese medical communitys lack of knowledge about the Act. The history of Minamata disease shows us the consequences when public health responses are not implemented. Minamata disease should be an invaluable lesson for future public health responses. © 2009 Palgrave Macmillan.

    DOI: 10.1057/jphp.2008.30

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  • Application of land use regression to regulatory air quality data in Japan

    Saori Kashima, Takashi Yorifuji, Toshihide Tsuda, Hiroyuki Doi

    SCIENCE OF THE TOTAL ENVIRONMENT   407 ( 8 )   3055 - 3062   2009年4月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    A land use regression (LUR) model has been used successfully for predicting traffic-related pollutants, although its application has been limited to Europe and North America. Therefore, we modeled traffic-related pollutants by LUR then examined whether LUR models could be constructed using a regulatory monitoring network in Shizuoka, Japan. We used the annual-mean nitrogen dioxide (NO(2)) and suspended particulate matter (SPM) concentrations between April 2000 and March 2006 in the study area. SPM accounts for particulate matter with an aerodynamic diameter less than 8 mu m (PM8). Geographic variables that are considered to predict traffic-related pollutants were classified into four groups: road type, traffic intensity, land use, and physical component. Using geographical variables, we then constructed a model to predict the monitored levels of NO(2) and SPM. The mean concentrations of NO(2) and SPM were 35.75 mu g/m(3) (standard deviation of 11.28) and 28.67 mu g/m(3) (standard deviation of 4.73), respectively. The final regression model for the NO(2) concentration included five independent variables. R(2) for the NO(2) model was 0.54. On the other hand, the regression model for the SPM concentration included only one independent variable. R(2) for the SPM model was quite low (R(2) = 0.11). The present study showed that even if we used regulatory monitoring air quality data, we could estimate NO(2) moderately well. This result could encourage the wide use of LUR models in Asian countries. (C) 2008 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.scitotenv.2008.12.038

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  • Minamata Disease. –A catastrophic poisoning due to failure of appropriate public health response.

    Tsuda Toshihide, Yorifuji Takashi, Takao Soshi, Miyai Masaya, Babazono Akira

    Journal of Public Health Policy   2009年

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  • Minamata disease: Catastrophic poisoning due to a failed public health response.

    Toshihide Tsuda, Takashi Yorifuji, Soshi Takao, Masaya, Miyai, Akira Babazono

    Journal of Public Health Policy 2009; 30: 54-67.   2009 ( 30 )   54 - 67   2009年

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  • 食中毒の疫学研修講座11.統計疫学入門:信頼区間と検定.

    津田敏秀, 槌田浩明, 溝口嘉範, 中瀬克巳, 山本英二, 土橋酉紀, 頼藤貴志, 土居弘幸

    食品衛生研究   2009年

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  • Training Program on Food-Borne Disease Epidemiology 8. A Study on a Food-Borne Disease Outbreak by Contaminated Lunch Boxes Distributed in a Sightseein Ship <II>

    Food Sanitation Research   59 ( 5 )   41 - 48   2009年

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  • Training Program on Food-Borne Disease Epidemiology 7. AStudy on a Food-Borne Disease Outbreak by Contaminated Lunch Boxes Distributed in a Sightseeing Ship <I>

    Food Sanitation Research   59 ( 4 )   29 - 37   2009年

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  • Training Program on Food-Borne Epidemiology 6. Introduction to Japanese Version of Epi Info<SUP>TM</SUP> Software for Epidemic Studies

    Food Sanitation Research   59 ( 3 )   35 - 43   2009年

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  • Training Program on Food-Borne Disease Epidemiology 4. Check Points for Creating Questionnaires and Data Collection

    Food Sanitation Research   59 ( 1 )   47 - 55   2009年

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  • Training Program on Food-Borne Disease Epidemiology 11. Primary Statistics in Epidemiology: Confidence Interval and Statistical Testing

    Food Sanitation Research   59 ( 8 )   53 - 61   2009年

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  • Training Program on Outbreak Epidemiology 10. Field Epidemiology Training Program-Japan.

    Food Sanitation Research   59 ( 7 )   53 - 59   2009年

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  • Training Program on Food-Borne Disease Epidemiology 5. Introduction to Japanese Version of Epi Info<SUP>TM</SUP> Software for Epidemic Studies.

    Food Sanitation Research   59 ( 2 )   17 - 26   2009年

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  • Training Program on Food-Borne Epidemiology 9. Study Designs and Practices

    Food Sanitation Research   59 ( 6 )   33 - 41   2009年

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  • Traing Program on Food-Borne Disease Epidemiology 14. Media and the Public. -Strategies for Outbreak Investigation and Countermeasure othe than Epidemiology-

    Food Sanitation Research   59 ( 11 )   29 - 39   2009年

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  • Training Program on Food-Borne Epidemiology 13. Case Control Study (1): Control Selection and Countermeasure in Food Poisoning Incident

    Food Sanitation Research   59 ( 10 )   25 - 33   2009年

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  • Training Program on Food-Borne Disease Epidemiology 12. Primary Statistics in Epidemiology: Supplementary Explanation

    Food Sanitation Research   59 ( 9 )   41 - 45   2009年

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  • Total hair mercury content and neurological signs in Minamata and neighboring communities.

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

    Epidemiology   in press   2009年

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  • 食中毒の疫学研修講座6.疫学統計ソフトEpi Info<SUP>TM</SUP>の使い方.

    食品衛生研究   59 ( 3 )   35 - 43   2009年

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  • 食中毒の疫学研修講座4.調査票作成およびデータ収集の留意点.

    食品衛生研究   59 ( 1 )   47 - 55   2009年

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  • Training Program on Food-Borne Disease Epidemiology 15. Case-Control Study (2): Encephalopahy Induced by Ingesting Pleurotus Mashroom

    Food Sanitation Research   59 ( 12 )   55 - 66   2009年

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  • 食中毒の疫学研修講座9.調査デザインと調査方針.

    食品衛生研究   59 ( 6 )   33 - 41   2009年

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  • 食中毒の疫学研修講座 8.観光船での汚染された弁当による集団食中毒事例(後編).

    食品衛生研究   59 ( 5 )   41 - 48   2009年

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  • 食中毒の疫学研修講座 7.観光船での汚染された弁当による集団食中毒事例(前編).

    食品衛生研究   59 ( 4 )   29 - 37   2009年

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  • 食中毒の疫学研修講座13.症例対照研究(1):対照の取り方と食中毒事件対策.

    食品衛生研究   59 ( 10 )   25 - 33   2009年

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  • 食中毒の疫学研修講座12.統計疫学入門:補足編.

    食品衛生研究   59 ( 9 )   41 - 45   2009年

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  • 食中毒の疫学研修講座11.統計疫学入門:信頼区間と検定.

    食品衛生研究   59 ( 8 )   53 - 61   2009年

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  • 食中毒の疫学研修講座10.実地疫学専門家養成コースFETP-Jと自治体でのアウトブレイク調査.

    食品衛生研究   59 ( 7 )   53 - 59   2009年

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  • 食中毒の疫学研修講座14.メディアとの連携-食中毒疫学調査と対策は疫学と調査法の理解だけではできない-.食品衛生研究2009;59(11):29-38.

    食品衛生研究   59 ( 11 )   29 - 39   2009年

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  • 食中毒の疫学研修講座5.疫学統計ソフトEpi InfoTM日本語版の紹介,インストールおよび基礎.

    食品衛生研究   59 ( 2 )   17 - 26   2009年

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  • Implications for future adverse effect studies of neuraminidase inhibitors (Rapid response to Neuraminidase inhibitors for preventing and treatinginfluenza in healthy adults: systematic review and meta-analysis byJefferson et al. BMJ 2009; 339: b5106).

    Yorifuji T, Tsuda T, Kashima S, Suzuki E, Doi H

    BMJ   2009年

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  • UNSCEAR 2006 inadequately cited “A case control study of multiple myeloma at four nuclear facilities” .

    Tsuda Toshihide, Yamamoto Eiji, Yorifuji Takashi

    Ann Epidemiol   2009年

  • Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome after breast-conserving therapy.

    Katayama Norihisa, Sato S, Katsui K, Takemoto M, Tsuda T, Yoshida A, Morito T, Nakagawa T, Mizuta A, Waki T, Niiya H, Kanazawa S

    International Journal of Radiation Oncology, Biology, Physics   2009年

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  • Total hair mercury content and neurological signs in Minamata and neighboring communities.

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

    Epidemiology   2009年

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  • 医学における因果推論 第一部 -研究と実践での議論を明瞭にするための反事実モデル-.

    鈴木越治, 小松裕和, 頼藤貴志, 山本英二, 土居弘幸, 津田敏秀

    日本衛生学雑誌   2009年

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  • 医学における因果推論 第一部 -研究と実践での議論を明瞭にするための反事実モデル-.

    日本衛生学雑誌2009;64:786-795.   64   786 - 795   2009年

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  • 昭和52年判断条件と認定問題と原因確率.

    津田敏秀

    法と民主主義   2009年

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  • 食中毒の疫学研修講座9.調査デザインと調査方針.

    槌田浩明, 中瀨克己, 溝口嘉範, 山本英二, 津田敏秀, 土居弘幸, 土橋酉紀

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座4.調査票作成およびデータ収集の留意点.

    槌田浩明, 中瀬克巳, 溝口嘉範, 山本英二, 津田敏秀, 土橋酉紀, 土居弘幸

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座15.症例対照研究(2):スギヒラタケによる脳症の発生.食品衛生研究2009;59(12):55-66.

    食品衛生研究   59 ( 12 )   55 - 66   2009年

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  • 食中毒の疫学研修講座 8.観光船での汚染された弁当による集団食中毒事例(後編).

    山本英二, 中瀬克巳, 槌田浩明, 溝口嘉範, 津田敏秀, 土橋酉紀, 土居弘幸

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座 7.観光船での汚染された弁当による集団食中毒事例(前編).

    山本英二, 中瀬克巳, 槌田浩明, 溝口嘉範, 津田敏秀, 土橋酉紀, 土居弘幸

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座6.疫学統計ソフトEpi InfoTMの使い方.

    山本英二, 中瀬克巳, 槌田浩明, 溝口嘉範, 津田敏秀, 土橋酉紀, 土居弘幸

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座5.疫学統計ソフトEpi InfoTM日本語版の紹介,インストールおよび基礎.

    山本英二, 中瀬克巳, 槌田浩明, 溝口嘉範, 津田敏秀, 土橋酉紀, 土居弘幸

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座15.症例対照研究(2):スギヒラタケによる脳症の発生.

    津田敏秀, 槌田浩明, 溝口嘉範, 中瀬克巳, 山本英二, 土居弘幸, 土橋酉紀, 頼藤貴志

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座14.メディアとの連携-食中毒疫学調査と対策は疫学と調査法の理解だけではできない-.

    津田敏秀, 槌田浩明, 溝口嘉範, 中瀬克巳, 山本英二, 土居弘幸, 土橋酉紀, 頼藤貴志

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座10.実地疫学専門家養成コースFETP-Jと自治体でのアウトブレイク調査.

    土橋酉紀, 土居弘幸, 頼藤貴志, 中瀬克巳, 槌田浩明, 溝口嘉範, 山本英二, 津田敏秀

    食品衛生研究   2009年

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  • 医学における因果推論 第二部 -交絡要因の選択とバイアスの整理および仮説の具体化に役立つDirected Acyclic Graph-.

    鈴木越治, 小松裕和, 頼藤貴志, 山本英二, 土居弘幸, 津田敏秀

    日本衛生学雑誌   2009年

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  • 医学における因果推論 第二部 -交絡要因の選択とバイアスの整理および仮説の具体化に役立つDirected Acyclic Graph-.

    日本衛生学雑誌2009;64:796-805.   64   796 - 805   2009年

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  • 水俣病における医学的問題と日本精神神経学会の取り組み.第104回日本精神神経学会総会教育講演.

    津田敏秀

    精神神経学雑誌   2009年

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  • 食中毒の疫学研修講座13.症例対照研究(1):対照の取り方と食中毒事件対策.

    津田敏秀, 槌田浩明, 溝口嘉範, 中瀬克巳, 山本英二, 土居弘幸, 土橋酉紀, 頼藤貴志

    食品衛生研究   2009年

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  • 食中毒の疫学研修講座12.統計疫学入門:補足編.食

    津田敏秀, 槌田浩明, 溝口嘉範, 中瀬克巳, 山本英二, 土橋酉紀, 頼藤貴志, 土居弘幸

    食品衛生研究   2009年

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  • Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor

    Fumiyo Higaki, Yoshihiro Okumura, Shuhei Sato, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Shiro Akaki, Toshihide Tsuda, Susumu Kanazawa

    ANNALS OF NUCLEAR MEDICINE   22 ( 3 )   157 - 163   2008年4月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Objective The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression.
    Methods We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 03 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUVmax were determined using receiver-operating characteristic (ROC) analysis.
    Results The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity.
    Conclusions The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

    DOI: 10.1007/s12149-007-0113-0

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  • Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor

    Fumiyo Higaki, Yoshihiro Okumura, Shuhei Sato, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Shiro Akaki, Toshihide Tsuda, Susumu Kanazawa

    ANNALS OF NUCLEAR MEDICINE   22 ( 3 )   157 - 163   2008年4月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Objective The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression.
    Methods We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 03 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUVmax were determined using receiver-operating characteristic (ROC) analysis.
    Results The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity.
    Conclusions The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

    DOI: 10.1007/s12149-007-0113-0

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  • Preliminary retrospective investigation of FDG-PET/CT timing in follow-up of ablated lung tumor

    Fumiyo Higaki, Yoshihiro Okumura, Shuhei Sato, Takao Hiraki, Hideo Gobara, Hidefumi Mimura, Shiro Akaki, Toshihide Tsuda, Susumu Kanazawa

    ANNALS OF NUCLEAR MEDICINE   22 ( 3 )   157 - 163   2008年4月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Objective The aim of this study was to clarify the most appropriate follow-up initiation time point for positron emission tomography (PET)/computed tomography (CT) following radio frequency ablation (RFA) of lung tumors, and the cutoff values of maximum standard uptake value (SUVmax) to evaluate local tumor progression.
    Methods We enrolled 15 patients (8 men, median age 62 years) with 60 tumors, who were treated with RFA of lung tumors and underwent fluorodeoxyglucose (FDG)-PET/CT following RFA. Local tumor progression was assessed by periodic chest CT images prior to and following intravenous administration of a contrast medium. The SUVmax of three periods, namely, 03 months, 3-6 months, and 6-9 months after RFA, was evaluated. The appropriate time point for follow-up initiation and the cutoff value of SUVmax were determined using receiver-operating characteristic (ROC) analysis.
    Results The median follow-up period was 357 days. Of 60 tumors, 10 showed local progression. The area under the ROC curve (Az) for the 6-9 months (P = 0.044) was the largest and almost equal to that of the 3-6 months (P = 0.024). Az for the 0-3 months was the smallest and statistically insignificant (P = 0.705). The cutoff value of 1.5 of SUVmax at 3-9 months after RFA showed 77.8% sensitivity and 85.7-90.5% specificity.
    Conclusions The appropriate follow-up initiation time point is at least 3 months following RFA. Thus, SUVmax is a useful and reliable predictive indicator.

    DOI: 10.1007/s12149-007-0113-0

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  • Causal interpretation based on DAGs

    Etsuji Suzuki, Hirokazu Komatsu, Takashi Yorifuji, Toshihide Tsuda,

    EPIDEMIOLOGY   19 ( 2 )   361 - 361   2008年3月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Causal interpretation based on DAGs

    Etsuji Suzuki, Hirokazu Komatsu, Takashi Yorifuji, Toshihide Tsuda,

    EPIDEMIOLOGY   19 ( 2 )   361 - 361   2008年3月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Long-term exposure to methylmercury and neurologic signs in Minamata and neighboring communities

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Masazumi Harada

    EPIDEMIOLOGY   19 ( 1 )   3 - 9   2008年1月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: It is well known that large-scale poisonings caused by methylmercury occurred in Japan (Minamata, in the 1950s) and Iraq. However, in contrast to Iraq, there have been few sound epidemiologic studies in Minamata. We evaluated the effect of methylmercury on neurologic signs using data from a 1971 population-based study.
    Methods: Villages in 3 areas were selected for study: the Minamata area (a high-exposure area), the Goshonoura area (a medium-exposure area), and the Ariake area (a low-exposure area). We used place of residence as the-exposure indicator. We examined associations between methylmercury exposure and the following neurologic signs measured on clinical examination: paresthesia of whole body, paresthesia of extremities, paresthesia around the mouth, ataxia, dysarthria, tremors, and pathologic reflexes.
    Results: Total population was 1120 in the high-exposure villages, 1845 in the medium-exposure villages, and 1165 in the low-exposure villages. In the Minamata area, 87% (n = 833) of the eligible population (age 10 years and older) participated in the 1971 investigations, in the Goshonoura area, 93% (n = 1450), and in the Ariake area, 77% (n = 755). Compared with subjects in the Ariake area, the subjects in the Minamata area manifested neurologic signs more frequently. The highest prevalence odds ratio was observed for paresthesia around the mouth (110; 95% confidence interval = 16-820). Although residents in the Goshonoura area had been exposed less heavily than those in the Minamata area, Goshonoura residents also had increased prevalence of neurologic signs.
    Conclusion: Long-term exposure to methylmercury has a strong adverse impact on neurologic signs among residents in a local community.

    DOI: 10.1097/EDE.0b013e31815c09d2

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  • Long-term exposure to methylmercury and neurologic signs in Minamata and neighboring communities

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Masazumi Harada

    EPIDEMIOLOGY   19 ( 1 )   3 - 9   2008年1月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Background: It is well known that large-scale poisonings caused by methylmercury occurred in Japan (Minamata, in the 1950s) and Iraq. However, in contrast to Iraq, there have been few sound epidemiologic studies in Minamata. We evaluated the effect of methylmercury on neurologic signs using data from a 1971 population-based study.
    Methods: Villages in 3 areas were selected for study: the Minamata area (a high-exposure area), the Goshonoura area (a medium-exposure area), and the Ariake area (a low-exposure area). We used place of residence as the-exposure indicator. We examined associations between methylmercury exposure and the following neurologic signs measured on clinical examination: paresthesia of whole body, paresthesia of extremities, paresthesia around the mouth, ataxia, dysarthria, tremors, and pathologic reflexes.
    Results: Total population was 1120 in the high-exposure villages, 1845 in the medium-exposure villages, and 1165 in the low-exposure villages. In the Minamata area, 87% (n = 833) of the eligible population (age 10 years and older) participated in the 1971 investigations, in the Goshonoura area, 93% (n = 1450), and in the Ariake area, 77% (n = 755). Compared with subjects in the Ariake area, the subjects in the Minamata area manifested neurologic signs more frequently. The highest prevalence odds ratio was observed for paresthesia around the mouth (110; 95% confidence interval = 16-820). Although residents in the Goshonoura area had been exposed less heavily than those in the Minamata area, Goshonoura residents also had increased prevalence of neurologic signs.
    Conclusion: Long-term exposure to methylmercury has a strong adverse impact on neurologic signs among residents in a local community.

    DOI: 10.1097/EDE.0b013e31815c09d2

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  • 食中毒の疫学研修講座3.疫学調査の流れと基本-納豆オクラ事例 2-.

    溝口嘉範, 中瀬克巳, 槌田浩明, 山本英二, 土橋酉紀, 土居弘幸, 津田敏秀

    食品衛生研究   2008年

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  • Mecal Issues in the Minamata Disease Incident, and the Approach by the Japanese Society for Psyciatry and Neurology

    Psychiatria et Neurologia Japonica   110 ( 11 )   1120 - 1125   2008年

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  • Training Program on Food-Borne Disease Epidemiology 1. Introdution of the Course Program and its Importance

    Food Sanitation Research   58 ( 10 )   7 - 15   2008年

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  • Electromagnetic Field and high-voltage transmission line- What is the problem? - WHO's Recommendation and the Japanese Bureaucracy

    The World   779 ( 5 )   185 - 194   2008年

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  • アスベストによる健康障害の疫学とリスクアセスメント―特に環境曝露による人体への影響に関して―.

    津田敏秀

    衆議院調査局環境調査室、解説資料:石綿関係法施行状況調査.   2008年

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  • アスベストによる健康障害の疫学とリスクアセスメント―特に環境曝露による人体への影響に関して―.

    津田敏秀

    衆議院調査局環境調査室、解説資料:石綿関係法施行状況調査.   2008年

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  • Training Program on Food-Borne Disease Epidemiology 3. Flow and Base of Epidemiologic Investigation- the Natto-Okra Incident 2

    Food Sanitation Research   58 ( 12 )   33 - 42   2008年

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  • Training Program on Food-Borne Disease Epidemiology 2. Flow and Base of Epidemiologic Investigation- the Natto-Okra Incident 1.

    Food Sanitation Research   58 ( 11 )   49 - 60   2008年

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  • 電磁波と高圧送電線・何が問題なのか-WHOの勧告と日本政府の対応.

    世界   779 ( 5 )   185 - 194   2008年

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  • Analysis of factors associated with radiation-induced bronchiolitis obliterans organizing pneumonia (BOOP) syndrome after breast-conserving therapy.

    International Journal of Radiation Oncology, Biology, Physics   2008年

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  • 食品衛生法を眠らせるな.

    津田敏秀

    朝日新聞   2008年

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  • Long-term exposure to methylmercury and neurological signs in Minamata and its neighboring communities: a population-based study.

    Yorifuji T, Tsuda T, Takao S, Harada M

    Epidemiology   2008年

  • Total hair mercury content and neurological signs in Minamata and neighboring communities.

    Takashi Yorifuji, Toshihide Tsuda, Soshi Takao, Etsuji Suzuki, Masazumi Harada

    Epidemiology   in press   2008年

  • 食中毒の疫学研修講座2.疫学調査の流れと基本-納豆オクラ事例 1-.

    食品衛生研究   58 ( 11 )   49 - 60   2008年

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  • 水俣病における医学的問題と日本精神神経学会の取り組み.第104回日本精神神経学会総会教育講演.

    精神神経学雑誌   110 ( 11 )   1120 - 1125   2008年

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  • 食中毒の疫学研修講座1.研修の現状と必要性-連載をはじめるにあたって-.

    食品衛生研究   58 ( 10 )   7 - 15   2008年

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  • Causal interpretation based on DAGs.

    Suzuki E, Komatsu H, Yorifuji T, Tsuda T

    Epidemiology   2008年

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  • 食品衛生法を眠らせるな.

    津田敏秀

    朝日新聞   2008年

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  • 食中毒の疫学研修講座3.疫学調査の流れと基本-納豆オクラ事例 2

    食品衛生研究   58 ( 12 )   33 - 42   2008年

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  • 電磁波と高圧送電線・何が問題なのか-WHOの勧告と日本政府の対応.

    津田敏秀

    世界   2008年

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  • 食中毒の疫学研修講座2.疫学調査の流れと基本-納豆オクラ事例 1-.

    溝口嘉範, 中瀬克巳, 槌田浩明, 山本英二, 土橋酉紀, 土居弘幸, 津田敏秀

    食品衛生研究   2008年

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  • 食中毒の疫学研修講座1.研修の現状と必要性-連載をはじめるにあたって-.

    中瀬克巳, 槌田浩明, 溝口嘉範, 山本英二, 土橋酉紀, 津田敏秀

    食品衛生研究   2008年

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  • 電磁波と高圧送電線・何が問題なのか-WHOの勧告と日本政府の対応.

    津田敏秀

    世界   2008年

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  • 電磁波と高圧送電線・何が問題なのか-WHOの勧告と日本政府の対応.

    津田敏秀

    世界   2008年

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  • EBMにおいてエビデンスを吟味する.

    津田敏秀

    大阪保険医雑誌   2008年

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  • Age standardized cancer mortality ratios in areas heavily exposed to methyl mercury

    Takashi Yorifuji, Toshihide Tsuda, Norito Kawakami

    INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   80 ( 8 )   679 - 688   2007年8月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Objective Methyl-mercury (MeHg) was discharged from a chemical factory in Minamata, and consequently spread throughout the Shiranui Sea in Kumamoto, Japan. Although many studies have focused on MeHg-induced neurological disorders, the association between MeHg and malignant neoplasms has not been adequately investigated. Therefore, we explored this association using the age standardized mortality ratio (ASMR) in an ecologic study over a wide area allowing for a long empirical induction period.
    Methods The subjects were residents in areas around the Shiranui Sea. We divided these areas into exposure groups 1 (Minamata and Ashikita regions) and 2 (Amakusa region). Exposure group 1 was contaminated from the late 1930s, and exposure group 2 was contaminated from the late 1950s. In addition, exposure group 1 was contaminated more heavily than exposure group 2. There were 92,525 and 152,541 residents in each group in 1960, respectively. We analyzed the cancer ASMR in both exposure groups using data from two reference populations (Japan and Kumamoto prefecture) from 1961 to 1997. There were 94,301,494 and 1,856,192 people in each reference group in 1960, respectively. We abstracted population and mortality data from the censuses and the vital statistics of the prefecture and Japan.
    Results An increased leukemia ASMR and a decreased gastric cancer ASMR were observed in both exposure groups, while other ASMRs were around unity and less precise. Furthermore, the leukemia ASMRs were elevated differently between the two exposure groups: the leukemia ASMR was already elevated early in the study period in exposure group 1 and increased gradually in exposure group 2.
    Conclusion While the negative association between MeHg and gastric cancer might be explained by salt intake, the positive association between MeHg and leukemia could not be explained by potential confounders. Despite some limitations mainly due to its ecologic design, this study indicates the necessity of an individual-level study evaluating the association between MeHg and leukemia in regions with exposure to MeHg.

    DOI: 10.1007/s00420-007-0179-y

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  • An epidemiological study of children with status epilepticus in Okayama, Japan

    Itsuko Nishiyama, Yoko Ohtsuka, Toshihide Tsuda, Hideo Inoue, Taiji Kunitomi, Hiroshi Shiraga, Takafumi Kimura, Kiyoshi Fujimoto

    EPILEPSIA   48 ( 6 )   1133 - 1137   2007年6月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING  

    Background: The incidence of status epilepticus (SE) in Asian children, including Japanese, has not been reported.
    Methods: In 2003, we performed an epidemiological study of SE on Japanese children (31 days or older to &lt; 15 years of age) in Okayama City by ascertaining all lifetime first episodes of SE.
    Results: Thirty-seven patients (22 males and 15 females) were identified. The annual incidence of SE was 38.8 per 100,000 population (95% CI: 24.5-49.5). Febrile SE in the absence of CNS infection accounted for 17. Acute symptomatic etiologies other than febrile SE were observed in eight patients, including three cases of influenza encephalitis/encephalopathy. Five were classified as remote symptomatic and the remaining seven as cryptogenic. The highest incidence (155.1/100,000) was seen in the age range of 31 days or older to &lt; 1 year, followed by 101.5/100,000 in the age range of one year, and the incidence decreased after eight years. In 26 of the 37 patients, SE was their first seizure. As for seizure types, 32 had convulsive SE, including tonic status in one. Five others showed nonconvulsive SE, including complex partial SE in four and absence status in one. No one died of SE. Two patients who brought on SE because of influenza encephalitis/encephalopathy suffered from motor disturbance with or without mental disturbance after SE.
    Conclusions: The incidence of SE tended to be higher in Japanese children than reported in Caucasians. The Japanese had an age-specific incidence pattern similar to that of Caucasians.

    DOI: 10.1111/j.1528-1167.2007.01106.x

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  • 論文の批判的吟味・長期間の携帯電話使用と脳腫瘍.

    津田敏秀

    物性研究   2007年

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  • Standardized cancer mortality ratios in areas heavily exposed to methyl mercury.

    Yorifuji T, Tsuda T, Kawakami N

    Int Arch Occup Environ Health 2007   80、679-688.   2007年

  • 論文の批判的吟味・長期間の携帯電話使用と脳腫瘍.

    津田敏秀

    物性研究   2007年

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  • Risk factors for local progression after percutaneous radiofrequency ablation of lung tumors - Evaluation based on a preliminary review of 342 tumors

    Takao Hiraki, Jun Sakurai, Toshihide Tsuda, Hideo Gobara, Yoshifumi Sano, Takashi Mukai, Soichiro Hase, Toshihiro Iguchi, Hiroyasu Fujiwara, Hiroshi Date, Susumu Kanazawa

    CANCER   107 ( 12 )   2873 - 2880   2006年12月

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    記述言語:英語   出版者・発行元:JOHN WILEY & SONS INC  

    BACKGROUND. The purpose of the study was to retrospectively evaluate the risk factors for local progression after percutaneous radiofrequency (AF) ablation of lung tumors.
    METHODS. The study included 128 patients (77 men, 51 women; mean age, 61.3 years) with 342 tumors (25 primary and 317 metastatic lung neoplasms; mean long-axis diameter, 1.7 cm) treated with RF ablation. The overall primary, and secondary technique effectiveness rates were estimated using Kaplan-Meier analysis. Multiple variables were analyzed using the log-rank test, followed by multivariate multilevel analysis to determine independent risk factors for local progression. The primary and secondary technique effectiveness rates were again estimated when considering only tumors without independent risk factors.
    RESULTS. The median follow-up period was 12 months (range, 6-47 months). The overall primary and secondary technique effectiveness rates were 72% and 84% at 1 year, 60% and 71% at 2 years, and 58% and 66% at 3 years, respectively. Larger turner size (hazard ratio [HR], 1.97; 95% confidence interval [95% CI], 1.47-2.65; P &lt;.00001) and the use of an internally cooled electrode (HR, 2.32; 95% CI, 1.10-4.90; P=.027) were assessed as independent risk factors for local progression. The primary and secondary technique effectiveness rates when considering tumors smaller than 2 cm and treated with a multitined expandable electrode were 89% and 89% at 1 year and 66% and 78% at 2 years, respectively.
    CONCLUSIONS. Larger tumor size and the use of an internally cooled electrode were independent risk factors for local progression after RF ablation of lung tumors.

    DOI: 10.1002/cncr.22333

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  • 産業医と疫学.認定産業医9.

    津田敏秀

    日本医事新報   2006年

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  • Can stress management at the workplace prevent depression? A randomized controlled trial

    Y Mino, A Babazono, T Tsuda, N Yasuda

    PSYCHOTHERAPY AND PSYCHOSOMATICS   75 ( 3 )   177 - 182   2006年

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    記述言語:英語   出版者・発行元:KARGER  

    Background. Stress, mental health and depression at the workplace have emerged as common and significant problems. The effectiveness of a stress-management program at the workplace was investigated. Methods: The effectiveness of a stress-management program was examined in workers at a highly stressful workplace using a randomized controlled trial. The 58 workers in the office were randomly assigned into a stress-management group (n = 28) and a control group (n = 30). The stress-management program included lectures on the perception of stress, measures to cope with it, stress-management recording sheets, and e-mail counseling. This program was based on the cognitive behavioral approach. The stress-management program was carried out for 3 months, and perceived work-related stress and psychological symptoms were evaluated using: General Health Questionnaire (GHQ)-30, Center for Epidemiologic Study for Depression (CES-D), the Questionnaire of Work-Related Stress and the Effort-Reward Imbalance Questionnaire. Twenty-one out of the 28 in the stressmanagement group and all in the control group were successfully followed up. Results: In the stress-management group, a significant improvement in the depressive symptoms was observed, compared with the control group in CES-D (p = 0.003 by two-tailed paired t-test, and p = 0.042 by repeated measure analysis of variance). In the multiple regression analysis, the effect of stress management on depressive symptoms at follow-up was significant (p = 0.041), controlling for potential confounding factors. However, the alleviation of perceived occupational stress was limited. Conclusions:A stress-management program based on the cognitive behavioral approach at the workplace may have potential for the prevention of depression.

    DOI: 10.1159/000091775

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  • 水俣病事件における医学的問題の概略

    津田敏秀

    解説資料:水俣病問題の概要An outline of the Minamata Disease Problem   2006年

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  • 認定制度は崩壊.水俣病公式確認50年.

    津田敏秀

    朝日新聞   2006年

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  • 食中毒だ!!とわかるまで.

    津田敏秀

    食と健康   2006年

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  • Understanding the impact of health policy: 10% co-payments for medical services reduce complaiance with necessary care among elderly patients with chronic disease in Japan.

    Akira Babazono, Motonobu Miyazaki, Hiroshi Une, Eiji Yamamoto, Toshihide Tsuda, Yoshio Mino, Alan L Hillman

    Journal of Health Science   2006年

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  • Health impact assessment of particulate matter in Tokyo, Japan.

    Yorifuji T, Yamamoto E, Tsuda T, Kawakami N

    Archives of Environmental and Occupational Health 2005   2005年

  • 「関西水俣病訴訟」上告審判決.

    津田敏秀

    科学   2005年

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  • Clostridium perfringens foodborne outbreak due to braised chop suey supplied by chafing dish.

    Ochiai H, Ohtsu T, Tsuda T, Kagawa H, Kawashima T, Takao S, Tsutsumi A, Kawakami N

    Acta Medica Okayama   2005年

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  • 大食中毒事件と病因物質.

    津田敏秀

    メディカル朝日   2005年

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  • 日本の医学医療の現状と科学.

    津田敏秀

    科学   2005年

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  • The relationship between epidemiological growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.

    Tokumo M, Toyooka S, Kiura K, Shigematsu H, Tomii K, Aoe M, Ichimura K, Tsuda T, Yano M, Tsukuda K, Tabata M, Ueoka H, Tanimoto M, Date H, Gazdar AF, Shimizu N

    Clinical Cancer Res   2005年

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  • A prospective study on the influences of workplace stress on mental health.

    Babazono A, Mino Y, Nagano J, Tsuda T, Araki T

    J Occup Health   2005年

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  • 人体への影響調査は被害拡大防止に有効.

    津田敏秀

    建築ジャーナル   2005年

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  • 日本の医学医療と公害事件-認定審査会は原理的に個人の「認定」に関する新しい知見をもたらさない.

    津田敏秀

    科学   2005年

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  • 解決に、疫学が役立つ課題は数多い.

    津田敏秀

    メディカル朝日   2005年

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  • アスベストと疫学、応用科学の存在考え直す時.

    津田敏秀

    朝日新聞   2005年

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  • Effects of the increase in co-payments from 20 to 30 percent on the compliance rate of patients with hypertension or diabetes mellitus in the employed health insurance system.

    Babazono A, Miyazaki M, Imatoh T, Une H, Yamamoto E, Tsuda T, Tanaka K, Tanihara S

    Int J Technology Assessment in Health Care 2005; 21: 228-233.   2005年

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  • Dose effect of smoking on aberrant methylation in non-small cell lung cancers

    S Toyooka, M Suzuki, T Tsuda, KO Toyooka, R Maruyama, K Tsukuda, Y Fukuyama, T Iizasa, T Fujisawa, N Shimizu, JD Minna, AF Gazdar

    INTERNATIONAL JOURNAL OF CANCER   110 ( 3 )   462 - 464   2004年6月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:WILEY-LISS  

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  • Prognosis after withdrawal of antiepileptic drugs in childhood-onset cryptogenic localization-related epilepsies

    H Ohta, Y Ohtsuka, T Tsuda, E Oka

    BRAIN & DEVELOPMENT   26 ( 1 )   19 - 25   2004年1月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    The purpose of this study was to clarify the risk factors of relapse following discontinuation of AEDs in patients with childhood-onset cryptogenic localization-related epilepsies. The subjects were 82 patients who fulfilled the following criteria: (1) age at first visit of less than 15 years, (2) follow-up period of more than 5 years, (3) suffering from cryptogenic localization-related epilepsies, and (4) the patient underwent AED withdrawal during the follow-up period. As a basic principle, we decided to start withdrawing AEDs when both of the following two conditions were met: (1) the patient had a seizure-free period of 3 years or more, and (2) there were no epileptic discharges on EEGs just prior to the start of withdrawal. Seizures recurred in eight of the 82 patients (9.8%). Univariate analysis revealed that the following factors were correlated with higher rates of seizure relapse: 6 years of age or higher at onset of epilepsy; 15 years of age or higher at the start of AED withdrawal, 5 years or more from the start of AED treatment to seizure control; five or more seizures before seizure control; and two or more AEDs administered before seizure control. Among these risk factors, 6 years of age or higher at onset and 5 years or more from the start of AED treatment to seizure control were determined by multivariate analysis to be independent risk factors for relapse. Thus, we conclude that the physician should be more careful in discontinuing AEDs in these higher-risk patients groups, and more generous in discontinuing AEDs in lower-risk groups. (C) 2003 Elsevier B.V. All rights reserved.

    DOI: 10.1016/S0387-7604(03)00089-5

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  • A study on a reduction in visits to physicians after introduction of 30% co-payments in the employee health in Japan.

    Babazono A, Miyazaki M, Une H, Yamamoto E, Tsuda T, Mino Y

    Ind Health   2004年

  • Does seropositivity for Helicobacter pylori antibodies increase outpatient costs for gastric and duodenal ulcer or inflammation?

    Babazono A, Miyazaki M, Une H, Yamamoto E, Tsuda T, Mino Y, Hillman AL

    Pharmacoeconomics   2004年

  • 食中毒事件としての水俣病事件.

    津田敏秀

    環境と公害   2004年

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  • 関西水俣病訴訟・最高裁判決を考える.

    津田敏秀

    神戸新聞   2004年

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  • Effects of an increase in patient copayments on medical service demands of the insured in Japan

    Akira Babazono, Toshihide Tsuda, Eiji Yamamoto, Yoshio Mino, Hiroshi Une, Alan L. Hillman

    International Journal of Technology Assessment in Health Care   19 ( 3 )   465 - 475   2003年6月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Objectives: To examine quantitatively the effects of an increase in patient copayments from 10% to 20% on the demand for medical services in Japan. Methods: The subjects of the study were the employees insured by the 1,797 health insurance societies, belonging to the National Federation of Health Insurance Societies, in 1996 and 1998. Indicators of medical service demands analyzed include the inpatient, outpatient, and dental case rates, the number of serviced days per case, the medical cost per day and the medical cost per insured. Results: When the effects of an increase in patient copayments from 10% to 20% were evaluated, taking into account the average age, the average monthly salary, the total number, the gender (male-to-female) ratio and the dependent ratio of the insured, the estimated change in the case rate was -6. 96% for inpatient, -4.79% for outpatient, and -5.77% for dental care. The estimated change in the number of serviced day per case was -4.66% for inpatient, -5.67% for outpatient, and -1.82% for dental care. The estimated change in the medical cost per day was -3.15% for inpatient, -13.00% for outpatient, and -11.48% for dental care. The estimated change in the medical cost per insured was -14.08% for inpatient, -21.54% for outpatient, and -18.11% for dental care. Conclusions: The increase in patient copayments from 10% to 20% enabled insurers to substantially reduce medical costs by cost shifting from the insurer to the insured, with resultant changes in the case rate and the number of service days per case.

    DOI: 10.1017/S0266462303000400

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  • The TP53 gene, tobacco exposure, and lung cancer

    S Toyooka, T Tsuda, AF Gazdar

    HUMAN MUTATION   21 ( 3 )   229 - 239   2003年3月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:WILEY-LISS  

    Of the various genetic alterations in lung cancer, the abnormalities of the TP53 gene (p53) are among the most frequent and important events. Because of its importance, many aspects of TP53 have been studied, including preneoplastic lesions and TP53 as a marker for early detection and prognosis and as a therapeutic option. We summarize recent knowledge of TP53 in lung cancer with a special emphasis on the relationship between smoking exposure (e.g, cigarette, etc.) and specific mutational pattern of TP53 by analyzing the latest version of the International Agency for Research on Cancer (IARC) database on TP53 mutations in human cancer. Our analysis confirmed several other studies showing significant differences in the frequencies of G:C to T:A transversions between ever-smokers and never-smokers. Furthermore, when comparing the mutational spectrum by gender, important differences were noted between male and female never smokers. We concluded that the previously noted G:C to T.A transversions were mainly due to female smokers having a high frequency of these changes compared to female never smokers. There was no relationship between adenocarcinomas and squamous cell carcinomas independent of gender. We also examined the seven codons which have been previously identified as hot spots, that is, the sites of frequent G:C to TA transversions in smoking,related lung cancers. However, there was no specific codon which was strongly related to smoke exposure despite a moderate relationship. We considered the term "warmspot" may be more appropriate. While mutations of TP53 are frequent in lung cancers, further investigation is necessary to understand their role for lung carcinogenesis, especially as they relate to gender differences, and to translate our laboratory knowledge to clinical applications.

    DOI: 10.1002/humu.10177

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  • Comparison of Tc-99m-GSA scintigrphy with hepatic fibrosis and regeneration in patients with hepatectomy.

    Iguchi T, Sato S, Kouno Y, Okumura Y, Akaki S, Tsuda T, Kobayashi K, Kanazawa S, Hiraki Y

    Annals of Nuclear Medicine   2003年

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  • 食中毒事件当たり患者数の年次推移に関する一考察.

    谷原真一, 山部清子, 大津忠弘, 津田敏秀, 中村好一, 藤田委由

    厚生の指標   2003年

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  • 疫学と行政判断-サリドマイド事件を例にして-.

    津田敏秀

    薬のチェックは命のチェック   2002年

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  • A Case-control study of lung cancer in relation to silica exposure and silicosis in a rural area in Japan.

    Toshihide Tsuda, Yoshio Mino, Akira Babazono, Jun Shigemi, Tadahiro Otsu, Eiji Yamamoto, Susumu Kanazawa

    Ann. Epidemiol   2002年

  • 疫学と根拠に基づく医学(EBM)から見た「脳死」問題

    津田敏秀, 大津忠弘, 茂見潤

    健康支援   4,2,107-110   2002年

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  • PearlのCausalityと行政判断

    山本英二, 津田敏秀

    岡山理科大学紀要   38,71-76   2002年

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  • 疫学と根拠に基づく医学(EBM)から見た「脳死」問題.

    津田敏秀, 大津忠弘, 茂見潤

    健康支援   2002年

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  • Smoking and mental health: Cross-sectional and cohort studies in an occupational setting in Japan

    Y Mino, J Shigemi, T Otsu, A Ohta, T Tsuda, N Yasuda, A Babazono, E Yamamoto

    PREVENTIVE MEDICINE   32 ( 4 )   371 - 375   2001年4月

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    記述言語:英語   出版者・発行元:ACADEMIC PRESS INC  

    Background The relationship between smoking and mental health remains unclear.
    Methods. We carried out a cross-sectional study and a cohort study on the possible association of smoking and mental health in 782 workers. Using a questionnaire including the 30-item General Health Questionnaire (GHQ-30) and items related to the smoking state, the association between smoking and mental health was evaluated separately in males and females. The subjects were classified into smokers and nonsmokers, and changes in the GHQ score during a 2-year followup period were evaluated. To control potential confounding factors, multiple regression analyses were performed.
    Results. The cross-sectional study showed mo difference in the GHQ score between smokers and nonsmokers among males but a significantly higher GHQ score for smokers than nonsmokers among females, This difference among females was confirmed to be significant by multiple regression analysis. The S-year cohort study showed a decrease in the GHQ score in each group and no reduction in the difference in the GHQ score between smokers and nonsmokers among females.
    Conclusions. No difference was observed in mental health between smokers and nonsmokers in males. However, in females, smokers showed poorer mental health than nonsmokers, and this difference remained unchanged even after 2 years. (C) 2001 American Health Foundation and Academic Press.

    DOI: 10.1006/pmed.2000.0803

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  • 根拠に基づく医学(EBM)の根拠

    津田敏秀

    月刊保団連   2001年

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  • 医学における因果関係の推論?意思決定?

    津田敏秀, 馬場園 明, 茂見 潤, 大津忠弘, 三野善央

    産業衛生学雑誌   43,161-173   2001年

  • A case-control study of the relationships among silica exposure, gastric cancer, and esophageal cancer

    Toshihide Tsuda, Yoshio Mino, Akira Babazono, Jun Shigemi, Tadahiro Otsu, Eiji Yamamoto

    American Journal of Industrial Medicine   39 ( 1 )   52 - 57   2001年

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    記述言語:英語  

    Background: We examined the effect of silica exposure on gastric and esophageal cancer mortality using a cancer control series in a population setting. Methods: Cases and controls were restricted to male subjects and were drawn from death certificates in the Tobi area of Japan. A control group was selected from a series of deaths due to colon cancer, and cancers of other organs. The Japanese death certificate system is comprehensive because all deaths must be reported to the local office and death certificates are written by medical doctors. Age and smoking habits adjusted the Mantel-Haenszel odds ratios were estimated. Results: For gastric cancer, the age-, smoking-adjusted odds ratios were 1.22 (95% CI 0.74-2.01)for colon cancer and the other cancer control for silica exposure work, and 1.36 (95% CI 0.76-2.43) for silicosis. For esophageal cancer, the age- and smoking-adjusted odds ratios were 1.53 (95% CI 0.59-3.96) for the cancer control for silica exposure, and 2.33 (95% CI 0.87-6.23) for silicosis, respectively. Conclusions: The results suggest that gastric and esophageal cancer were related to silica exposure and silicosis in the study area, although they did not reach a statistically significant level because of the small sample size. The estimated odds ratios were higher for esophageal cancer and silicotic patients. © 2001 Wiley-Liss, Inc.

    DOI: 10.1002/1097-0274(200101)39:1<52::AID-AJIM5>3.0.CO;2-C

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  • A case-control study of the relationships among silica exposure, gastric cancer, and esophageal cancer

    Tsuda T, Mino Y, Babazono A, Shigemi J, Otsu T, Yamamoto E

    Am J Ind Med   2001年

  • A case-control study of the relationships among silica exposure, gastric cancer, and esophageal cancer

    Toshihide Tsuda, Yoshio Mino, Akira Babazono, Jun Shigemi, Tadahiro Otsu, Eiji Yamamoto

    American Journal of Industrial Medicine   39 ( 1 )   52 - 57   2001年

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    記述言語:英語  

    Background: We examined the effect of silica exposure on gastric and esophageal cancer mortality using a cancer control series in a population setting. Methods: Cases and controls were restricted to male subjects and were drawn from death certificates in the Tobi area of Japan. A control group was selected from a series of deaths due to colon cancer, and cancers of other organs. The Japanese death certificate system is comprehensive because all deaths must be reported to the local office and death certificates are written by medical doctors. Age and smoking habits adjusted the Mantel-Haenszel odds ratios were estimated. Results: For gastric cancer, the age-, smoking-adjusted odds ratios were 1.22 (95% CI 0.74-2.01)for colon cancer and the other cancer control for silica exposure work, and 1.36 (95% CI 0.76-2.43) for silicosis. For esophageal cancer, the age- and smoking-adjusted odds ratios were 1.53 (95% CI 0.59-3.96) for the cancer control for silica exposure, and 2.33 (95% CI 0.87-6.23) for silicosis, respectively. Conclusions: The results suggest that gastric and esophageal cancer were related to silica exposure and silicosis in the study area, although they did not reach a statistically significant level because of the small sample size. The estimated odds ratios were higher for esophageal cancer and silicotic patients. © 2001 Wiley-Liss, Inc.

    DOI: 10.1002/1097-0274(200101)39:1<52::AID-AJIM5>3.0.CO;2-C

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  • Effects of a one-hour educational program on attitudes towards mental illness among medical students

    Mino Y, Yasuda N, Tsuda T, Shimodera S

    Psychiatry Clin Neurosci   2001年

  • 喫煙とメンタルヘルスとの関連について-職域における調査より-

    大津忠弘, 三野善央, 茂見 潤, 太田充彦, 高尾総司, 津田敏秀, 安田誠史, 馬場園 明, 山本英二, 青山英康

    健康開発   2001年

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  • 健康保険組合における老人医療費の負担指標に関する研究

    馬場園 明, 山本英二, 津田敏秀, 三野善央

    医療経済研究   2001年

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  • 保健医療における因果関係の推論-疫学の立場からの科学哲学的考察-

    津田敏秀, 茂見 潤, 大津忠弘, 馬場園 明

    健康支援   2001年

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  • Effects of perceived job stress on mental health. A longitudinal survey in a Japanese electronics company

    Jun Shigemi, Yoshio Mino, Tadahiro Ohtsu, Toshihide Tsuda

    European Journal of Epidemiology   16 ( 4 )   371 - 376   2000年

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    記述言語:英語  

    We conducted a cohort study for 2 years to examine the causal relationship between perceived job stress and mental health. Questionnaire surveys, including a 30-item General Health Questionnaire (GHQ) and a questionnaire on perceived job stress were carried out every 6 months for 2 years. To clarify the causal relationship between job stress and mental health, we followed a group of workers who initially had a GHQ score ≤7. Out of 462 workers who were thought to be in a healthy mental state, 282 were successfully followed for 2 years. We considered subjects who developed unhealthy mental health states (GHQ score ≥8) as hazardous cases. To control potential confounding factors, proportional hazard analysis was done. The overall proportion hazardous cases detected in the development of an unhealthy mental health state over two years was 55.7%. Using Cox's proportional hazard model, workers who complained of perceived job stress had a greater hazard than those without job stress. In particular, the item 'poor relationship with superior' showed the largest adjusted hazard ratio [95% confidence interval (CI)] of 1.51 (1.06 - 2.15). The item 'too much trouble at work' also had a significant hazardous effect on mental health with an adjusted hazard ratio (95% CI) of 1.43 (1.00-2.04). Some specific items of perceived job stress could cause mental ill health in workers.

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  • Effects of perceived job stress on mental health. A longitudinal survey in a Japanese electronics company

    Jun Shigemi, Yoshio Mino, Tadahiro Ohtsu, Toshihide Tsuda

    European Journal of Epidemiology   16 ( 4 )   371 - 376   2000年

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    記述言語:英語  

    We conducted a cohort study for 2 years to examine the causal relationship between perceived job stress and mental health. Questionnaire surveys, including a 30-item General Health Questionnaire (GHQ) and a questionnaire on perceived job stress were carried out every 6 months for 2 years. To clarify the causal relationship between job stress and mental health, we followed a group of workers who initially had a GHQ score ≤7. Out of 462 workers who were thought to be in a healthy mental state, 282 were successfully followed for 2 years. We considered subjects who developed unhealthy mental health states (GHQ score ≥8) as hazardous cases. To control potential confounding factors, proportional hazard analysis was done. The overall proportion hazardous cases detected in the development of an unhealthy mental health state over two years was 55.7%. Using Cox's proportional hazard model, workers who complained of perceived job stress had a greater hazard than those without job stress. In particular, the item 'poor relationship with superior' showed the largest adjusted hazard ratio [95% confidence interval (CI)] of 1.51 (1.06 - 2.15). The item 'too much trouble at work' also had a significant hazardous effect on mental health with an adjusted hazard ratio (95% CI) of 1.43 (1.00-2.04). Some specific items of perceived job stress could cause mental ill health in workers.

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  • A meta-analysis on the relationship between pneumoconiosis and lung cancer

    Toshihide Tsuda, Akira Babazono, Eiji Yamamoto, Yoshio Mino, Hiroaki Matsuoka

    Journal of Occupational Health   39 ( 4 )   285 - 294   1997年

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    記述言語:英語   出版者・発行元:Japan Society for Occupational Health  

    An excess of lung cancer deaths among pneumoconiosis patients has been noted for many years but there has not been agreement on the excess of lung cancer deaths among pneumoconiosis patients in Japan. A meta-analysis on the relationship between silicosis/pneumoconiosis and lung cancer mortality was conducted, by using 36 mortality studies published from 1950 to 1994. MEDICINE and other information sources were used for the information retrieval. After the critical appraisal, 32 eligible studies were identified. Study estimates were then pooled by using both the fixed effect model and the random effect model. An excess of lung cancer mortality among people with silicosis/pneumoconiosis was shown in all 32 studies. Although homogeneity among the studies was rejected (p&lt
    0.05) because the shape of the funnel plots assumed a symmetrical pyramidal shape, the summary rate ratio was estimated. The estimated rate ratio was 2.74 (95 percent confidence interval 2.60-2.90) in all 32 studies, and 2.77 (2.61-2.94) in 25 cohort studies. The random effect model results were almost the same as the fixed model results. The estimates in the Japanese studies were a little higher than the overall estimates, which indicated that lung cancer mortality was about three times higher among silicotic patients than among people in the control. This indicated a causal-relationship between silicosis and lung cancer. This means that lung cancer should be regarded as one of the important complications of silicosis/pneumoconiosis. We recommend further research on the relationship between silica exposure and lung cancer.

    DOI: 10.1539/joh.39.285

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  • A meta-analysis on the relationship between pneumoconiosis and lung cancer

    Toshihide Tsuda, Akira Babazono, Eiji Yamamoto, Yoshio Mino, Hiroaki Matsuoka

    Journal of Occupational Health   39 ( 4 )   285 - 294   1997年

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    記述言語:英語   出版者・発行元:Japan Society for Occupational Health  

    An excess of lung cancer deaths among pneumoconiosis patients has been noted for many years but there has not been agreement on the excess of lung cancer deaths among pneumoconiosis patients in Japan. A meta-analysis on the relationship between silicosis/pneumoconiosis and lung cancer mortality was conducted, by using 36 mortality studies published from 1950 to 1994. MEDICINE and other information sources were used for the information retrieval. After the critical appraisal, 32 eligible studies were identified. Study estimates were then pooled by using both the fixed effect model and the random effect model. An excess of lung cancer mortality among people with silicosis/pneumoconiosis was shown in all 32 studies. Although homogeneity among the studies was rejected (p&lt
    0.05) because the shape of the funnel plots assumed a symmetrical pyramidal shape, the summary rate ratio was estimated. The estimated rate ratio was 2.74 (95 percent confidence interval 2.60-2.90) in all 32 studies, and 2.77 (2.61-2.94) in 25 cohort studies. The random effect model results were almost the same as the fixed model results. The estimates in the Japanese studies were a little higher than the overall estimates, which indicated that lung cancer mortality was about three times higher among silicotic patients than among people in the control. This indicated a causal-relationship between silicosis and lung cancer. This means that lung cancer should be regarded as one of the important complications of silicosis/pneumoconiosis. We recommend further research on the relationship between silica exposure and lung cancer.

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  • Causal inference in medicine - A historical view in epidemiology

    Toshihide Tsuda, Akira Babazono, Yoshio Mino, Hiroaki Matsuoka, Eiji Yamamoto

    Japanese Journal of Hygiene   51 ( 2 )   558 - 568   1996年

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    記述言語:日本語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:Japanese Society for Hygiene  

    Changes of causal inference concepts in medicine, especially those having to do with chronic diseases, were reviewed. The review is divided into five sections. First, several articles on the increased academic acceptance of observational research are cited. Second, the definitions of confounder and effect modifier concepts are explained. Third, the debate over the so-called "criteria for causal inference" was discussed. Many articles have pointed out various problems related to the lack of logical bases for standard criteria, however, such criteria continue to be misapplied in Japan. Fourth, the Popperian and verificationist concepts of causal inference are summarized. Lastly, a recent controversy on meta-analysis is explained. Causal inference plays an important role in epidemiologic theory and medicine. However, because this concept has not been well-introduced in Japan, there has been much misuse of the concept, especially when used for conventional criteria.

    DOI: 10.1265/jjh.51.558

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  • Causal inference in medicine - A historical view in epidemiology

    Toshihide Tsuda, Akira Babazono, Yoshio Mino, Hiroaki Matsuoka, Eiji Yamamoto

    Japanese Journal of Hygiene   51 ( 2 )   558 - 568   1996年

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    記述言語:日本語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:Japanese Society for Hygiene  

    Changes of causal inference concepts in medicine, especially those having to do with chronic diseases, were reviewed. The review is divided into five sections. First, several articles on the increased academic acceptance of observational research are cited. Second, the definitions of confounder and effect modifier concepts are explained. Third, the debate over the so-called "criteria for causal inference" was discussed. Many articles have pointed out various problems related to the lack of logical bases for standard criteria, however, such criteria continue to be misapplied in Japan. Fourth, the Popperian and verificationist concepts of causal inference are summarized. Lastly, a recent controversy on meta-analysis is explained. Causal inference plays an important role in epidemiologic theory and medicine. However, because this concept has not been well-introduced in Japan, there has been much misuse of the concept, especially when used for conventional criteria.

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  • Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic

    Toshihide Tsuda, Eiji Yamamoto, Akira Babazono, Yoshio Mino, Yoshiki Kishi, Norio Kurumatani, Takanori Ogawa, Hideyasu Aoyama

    Applied Organometallic Chemistry   8 ( 3 )   237 - 244   1994年

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    記述言語:英語  

    Survival analysis was used to analyze follow‐up data on an arsenic‐poisoned area, identified in 1959, in order to assess the effect of arsenic on survival time. The subjects were 443 residents of Namiki‐cho, Nakajo‐machi, Niigata Prefecture, Japan, who ingested well water contaminated with arsenic between 1955 and 1959. Their exposure to arsenic was only by ingestion of well water. We observed this historical cohort from October 1959 to February 1992. Survival time was calculated in two ways: from 1959 (the end of exposure) until death or until 1992 (the termination of follow‐up)
    or from birth until death or until 1992. The entire cohort was divided into two groups according to the arsenic concentration measured in the wells in 1959. Different survival curves of the two were drawn using the Kaplan–Meier method. The lifetime survival curves indicate that the lifetimes of arsenic‐exposed residents were significantly shorter than that of the low‐dose exposure group or of unexposed residents. From the differences in the estimated lifetime survival curves, the effect of arsenic on the mortality of the residents can be inferred. Copyright © 1994 John Wiley &amp
    Sons, Ltd.

    DOI: 10.1002/aoc.590080313

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  • Comparisons of survival time estimates for niigata prefecture (japan) residents exposed to ingested arsenic

    Toshihide Tsuda, Eiji Yamamoto, Akira Babazono, Yoshio Mino, Yoshiki Kishi, Norio Kurumatani, Takanori Ogawa, Hideyasu Aoyama

    Applied Organometallic Chemistry   8 ( 3 )   237 - 244   1994年

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    記述言語:英語  

    Survival analysis was used to analyze follow‐up data on an arsenic‐poisoned area, identified in 1959, in order to assess the effect of arsenic on survival time. The subjects were 443 residents of Namiki‐cho, Nakajo‐machi, Niigata Prefecture, Japan, who ingested well water contaminated with arsenic between 1955 and 1959. Their exposure to arsenic was only by ingestion of well water. We observed this historical cohort from October 1959 to February 1992. Survival time was calculated in two ways: from 1959 (the end of exposure) until death or until 1992 (the termination of follow‐up)
    or from birth until death or until 1992. The entire cohort was divided into two groups according to the arsenic concentration measured in the wells in 1959. Different survival curves of the two were drawn using the Kaplan–Meier method. The lifetime survival curves indicate that the lifetimes of arsenic‐exposed residents were significantly shorter than that of the low‐dose exposure group or of unexposed residents. From the differences in the estimated lifetime survival curves, the effect of arsenic on the mortality of the residents can be inferred. Copyright © 1994 John Wiley &amp
    Sons, Ltd.

    DOI: 10.1002/aoc.590080313

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  • An epidemiologic research design using the annual of the pathological autopsy cases in Japan

    T. Tsuda, E. Yamamoto, A. Babazono, Y. Mino, T. Ogawa, J. Shigemi, H. Aoyama

    Japanese Journal of Hygiene   49 ( 4 )   753 - 761   1994年

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    記述言語:日本語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:Japanese Society for Hygiene  

    Epidemiologic research designs using the Annual of the Pathological Autopsy Cases in Japan (APAC hereinafter) are discussed in this paper. The APAC data base has been recommended for use in epidemiologic research. However, it has not often been utilized for such research, even though it covers all pathological autopsy cases in Japan, perhaps because of different sampling proportions of each disease and because of the dead control series in APAC. First, we present epidemiologic measures in using the APAC. We show that the data base can be treated as a case-control design and that the magnitude of the exposure effect should be estimated by an odds ratio. Next, selection bias and information bias in using the APAC are discussed. The independence of the control series from the exposure is important in the determination of the control disease. Because this design is based on internal comparison, non-differential misclassification should be stressed more than differential misclassification.

    DOI: 10.1265/jjh.49.753

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  • An epidemiologic research design using the annual of the pathological autopsy cases in Japan

    T. Tsuda, E. Yamamoto, A. Babazono, Y. Mino, T. Ogawa, J. Shigemi, H. Aoyama

    Japanese Journal of Hygiene   49 ( 4 )   753 - 761   1994年

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    記述言語:日本語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:Japanese Society for Hygiene  

    Epidemiologic research designs using the Annual of the Pathological Autopsy Cases in Japan (APAC hereinafter) are discussed in this paper. The APAC data base has been recommended for use in epidemiologic research. However, it has not often been utilized for such research, even though it covers all pathological autopsy cases in Japan, perhaps because of different sampling proportions of each disease and because of the dead control series in APAC. First, we present epidemiologic measures in using the APAC. We show that the data base can be treated as a case-control design and that the magnitude of the exposure effect should be estimated by an odds ratio. Next, selection bias and information bias in using the APAC are discussed. The independence of the control series from the exposure is important in the determination of the control disease. Because this design is based on internal comparison, non-differential misclassification should be stressed more than differential misclassification.

    DOI: 10.1265/jjh.49.753

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    PubMed

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  • Depressive states in workers using computers

    Yoshio Mino, Toshihide Tsuda, Akira Babazono, Hideyasu Aoyama, Simpei Inoue, Hirotoshi Sato, Hirosh Ohara

    Environmental Research   63 ( 1 )   54 - 59   1993年

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    記述言語:英語  

    There have been few reports investigating the depressive states in workers using computers. We describe the depressive states observed in workers using computers and discuss the sources of their occupational stresses. The first subject is a 34-year-old male manager of a manufacturing company who had customarily worked until 9 PM. In 1985, it became necessary for him to work until midnight
    symptoms of depression began to appear during this period, exacerbated after trouble with a computer. In 1986, he visited a psychiatrist and his condition was diagnosed as Major Depression according to DSM-III. The second subject is a 26-year-old male VDT (visual display terminal) operator in a general hospital. Before the onset, he had had to work until 8 PM and, at the end of each month, until midnight. Two months later, he became depressed and his condition was diagnosed as Major Depression according to DSM-III. The third subject is a 32-year-old male chief in the computer programming section of a bank. He had had to work until 8 PM, became depressed, and visited a psychiatrist who diagnosed his condition as Major Depression according to DSM-III. The authors discuss these cases from the standpoint of occupational stresses, as they are associated with work overload, and the important role these stresses played in the onset of the workers’ depressive states. © 1993 Academic Press.

    DOI: 10.1006/enrs.1993.1126

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  • Depressive States in Workers Using Computers (共著)

    Environmental Research   63 ( 1 )   54 - 59   1993年

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    記述言語:英語  

    DOI: 10.1006/enrs.1993.1126

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  • Inorganic arsenic: A dangerous enigma for mankind

    Toshihide Tsuda, Akira Babazono, Takanori Ogawa, Hirohisa Hamada, Yoshio Mino, Hideyasu Aoyama, Norio Kurumatani, Tsuyoshi Nagira, Nobuyuki Hotta, Masazumi Harada, Shigemi Inomata

    Applied Organometallic Chemistry   6 ( 4 )   309 - 322   1992年

     詳細を見る

    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Human being have been using inorganic arsenic for a long time. Many reports on arsenic poisoning have been published: eg case reports, examination reports, post mortem reports, and epidemiological studies. Several aspects and features of arsenic poisoning are discussed in this report. Methods of inferring arsenic‐related disease, disease classification according to acute or chronic criteria, exposure route, interaction, confounding factors, and the oxidation state of arsenic are all discussed. The effects of arsenic are classified into skin, respiratory system, gastrointestinal tract, liver, cardiovascular system, nervous system, and bone marrow effects. Carcinogenicity is an important chronic effect of arsenic poisoning, so special attention is paid to it in this review. In Japan, there have been many incidents of arsenic poisoning. In this review, we often use data from these cases, such as the Morinaga powdered‐milk poisoning case, the Ube soy‐sauce poisoning case, the Toroku mine incident, and the Nakajo well‐water poisoning case. We emphasize here the necessity of planning follow‐up studies and total health care for patients exposed to arsenic. Copyright © 1992 John Wiley &amp
    Sons Ltd.

    DOI: 10.1002/aoc.590060403

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  • Historical cohort studies in three arsenic poisoning areas in japan

    Toshihide Tsuda, Takanori Ogawa, Akira Babazono, Hirohisa Hamada, Susumu Kanazawa, Yoshio Mino, Hideyasu Aoyaam, Eiji Yamamoto, Norio Kurumatani

    Applied Organometallic Chemistry   6 ( 4 )   333 - 341   1992年

     詳細を見る

    記述言語:英語  

    The results of historical cohort studies of three arsenic poisoning incidents in Japan are presented. The first episode was in a small mountainous community near an arsenic mine and refinery, at Toroku, where patients with chronic arsenism were certified by application of the Pollution Health Damage Compensation Law. The second area was in a small town, Namiki‐cho, near Nakajo‐machi, where wells were poisoned by arsenic produced in an arsenic(III) sulfide factory. As to the third cohort, eight residents of Nishikawa‐machi who ingested well‐water suffered arsenic poisoning about 35 years ago. The standardized mortality ratios were used in analyzing these data. Excesses of cancer mortality, especially lung cancer, were observed among the subjects in these areas. In Japan, there are many arsenic poisoning episodes, involving for example soy‐sauce poisoning, powdered‐milk poisoning and other incidents associated with arsenic mines. Thus it is necessary to clarify the chronic effects of arsenic in these areas. Copyright © 1992 John Wiley &amp
    Sons Ltd.

    DOI: 10.1002/aoc.590060405

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  • Historical cohort studies in three arsenic poisoning areas in japan

    Toshihide Tsuda, Takanori Ogawa, Akira Babazono, Hirohisa Hamada, Susumu Kanazawa, Yoshio Mino, Hideyasu Aoyaam, Eiji Yamamoto, Norio Kurumatani

    Applied Organometallic Chemistry   6 ( 4 )   333 - 341   1992年

     詳細を見る

    記述言語:英語  

    The results of historical cohort studies of three arsenic poisoning incidents in Japan are presented. The first episode was in a small mountainous community near an arsenic mine and refinery, at Toroku, where patients with chronic arsenism were certified by application of the Pollution Health Damage Compensation Law. The second area was in a small town, Namiki‐cho, near Nakajo‐machi, where wells were poisoned by arsenic produced in an arsenic(III) sulfide factory. As to the third cohort, eight residents of Nishikawa‐machi who ingested well‐water suffered arsenic poisoning about 35 years ago. The standardized mortality ratios were used in analyzing these data. Excesses of cancer mortality, especially lung cancer, were observed among the subjects in these areas. In Japan, there are many arsenic poisoning episodes, involving for example soy‐sauce poisoning, powdered‐milk poisoning and other incidents associated with arsenic mines. Thus it is necessary to clarify the chronic effects of arsenic in these areas. Copyright © 1992 John Wiley &amp
    Sons Ltd.

    DOI: 10.1002/aoc.590060405

    Scopus

    researchmap

  • Inorganic arsenic: A dangerous enigma for mankind

    Toshihide Tsuda, Akira Babazono, Takanori Ogawa, Hirohisa Hamada, Yoshio Mino, Hideyasu Aoyama, Norio Kurumatani, Tsuyoshi Nagira, Nobuyuki Hotta, Masazumi Harada, Shigemi Inomata

    Applied Organometallic Chemistry   6 ( 4 )   309 - 322   1992年

     詳細を見る

    記述言語:英語   掲載種別:書評論文,書評,文献紹介等  

    Human being have been using inorganic arsenic for a long time. Many reports on arsenic poisoning have been published: eg case reports, examination reports, post mortem reports, and epidemiological studies. Several aspects and features of arsenic poisoning are discussed in this report. Methods of inferring arsenic‐related disease, disease classification according to acute or chronic criteria, exposure route, interaction, confounding factors, and the oxidation state of arsenic are all discussed. The effects of arsenic are classified into skin, respiratory system, gastrointestinal tract, liver, cardiovascular system, nervous system, and bone marrow effects. Carcinogenicity is an important chronic effect of arsenic poisoning, so special attention is paid to it in this review. In Japan, there have been many incidents of arsenic poisoning. In this review, we often use data from these cases, such as the Morinaga powdered‐milk poisoning case, the Ube soy‐sauce poisoning case, the Toroku mine incident, and the Nakajo well‐water poisoning case. We emphasize here the necessity of planning follow‐up studies and total health care for patients exposed to arsenic. Copyright © 1992 John Wiley &amp
    Sons Ltd.

    DOI: 10.1002/aoc.590060403

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  • A Case of Lung Cancer Associated with Chronic Arsenic Poisoning Caused by Neighborhood Exposure of As2O3 from Toroku Mine

    Toshihide Tsuda, Hideyasu Aoyama, Yufcinori Kume, Makoto Yamamoto, Tsuyosi Nagira

    Japanese Journal of Industrial Health   29 ( 3 )   222 - 223   1987年

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  • A Case of Lung Cancer Associated with Chronic Arsenic Poisoning Caused by Neighborhood Exposure of As2O3 from Toroku Mine

    Toshihide Tsuda, Hideyasu Aoyama, Yufcinori Kume, Makoto Yamamoto, Tsuyosi Nagira

    Japanese Journal of Industrial Health   29 ( 3 )   222 - 223   1987年

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  • An Epidemiological Study on Cancer in Certified Arsenic Poisoning Patients in Toroku

    Toshihide Tsuda, Yukinori Kume, Hideyasu Aoyama, Makoto Yamamoto, Tsuyoshi Nagira

    Japanese Journal of Industrial Health   29 ( 6 )   496 - 497   1987年

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  • An Epidemiological Study on Cancer in Certified Arsenic Poisoning Patients in Toroku

    Toshihide Tsuda, Yukinori Kume, Hideyasu Aoyama, Makoto Yamamoto, Tsuyoshi Nagira

    Japanese Journal of Industrial Health   29 ( 6 )   496 - 497   1987年

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Works(作品等)

  • A Report on the Indicators of Maternal and Child health in Okayama Prefecture

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    作品分類:芸術活動  

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  • A Report on Methods for the Investigation on the Causal Relationship between Air Pollution and Respiratory Diseases

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    作品分類:芸術活動  

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  • 精神疾患のプライマリ・ケア・サーベイ(平成4〜6年度科学研究費補助金(一般研究(A))研究成果報告書,課題番号:04404039,研究代表者:青山英康)

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  • A Report on the Indicators of Maternal and Child health in Okayama Prefecture

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  • A Report on Methods for the Investigation on the Causal Relationship between Air Pollution and Respiratory Diseases

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    作品分類:芸術活動  

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  • Epidemiologic Investigation on Food Poisoning - Seminar of Okayama City on Outbreak Investigation

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    作品分類:芸術活動  

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  • Epidemiologic Evidence of Infectious Disease and Food Poisoning - Public Health Seminar of Sakai City

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    作品分類:芸術活動  

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  • 岡山県母子保健指標に関する報告書

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    作品分類:芸術活動  

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  • 大気汚染と呼吸器疾器との関連についての調査方法検討報告書

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    作品分類:芸術活動  

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  • Epidemiologic Investigation on Food Poisoning - Seminar of Okayama City on Outbreak Investigation

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    作品分類:芸術活動  

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  • Epidemiologic Evidence of Infectious Disease and Food Poisoning - Public Health Seminar of Sakai City

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    作品分類:芸術活動  

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  • 岡山市食中毒疫学調査研修会 食中毒の疫学調査

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  • 堺市保健婦研修 感染症の疫学的検証

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  • 健康増進活動のための健康外来システムの開発とその評価(厚生科学研究費補助金健康科学総合研究事業研究報告書,主任研究者:馬場園明)

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  • 岡山県東南部地域に多発した肺癌に関する疫学的研究 (平成8〜10年度科学研究費補助金(基盤研究(C)(2))研究成果報告書,課題番号:08670393,研究代表者:津田敏秀)

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  • 職場のストレスのメンタルヘルスに及ぼす影響の定量的評価(平成7〜9年度科学研究費補助金(基盤研究(B))研究成果報告書,課題番号:07457095,研究代表者:三野善央)

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受賞

  • 新潟水俣 環境賞

    1999年  

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    受賞国:日本国

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  • 産業保健学 (2020年度) 後期  - 金4,金5

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  • 疫学分析・演習Ⅰ (2020年度) 特別  - その他

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