Faculty Profiles - MATSUO Toshihiko

Papers - MATSUO Toshihiko

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Managing Persistent Pupillary Membranes With Surgery or Medication: A Report of Three Cases Reviewed

Toshihiko Matsuo, Takehiro Tanaka

Cureus 17 ( 6 ) e86695 2025.6

Whole-Eye Radiation for the Local Control of Choroidal Lymphoma in Primary Central Nervous System Lymphoma: A 14-Year Case Study Reviewed

Toshihiko Matsuo, Tomofumi Yano, Kotaro Yoshio, Takehiro Tanaka, Hirotake Nishimura, Ken-ichi Matsuoka

Cureus 17 ( 6 ) e85680 2025.6

Detailed Ophthalmic and Pathological Features of Choroidal Metastasis From Breast Cancer: A Case Series of Five Patients. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Tadahiko Shien, Atsushi Muraoka, Hiroyoshi Doihara

Cureus 17 ( 5 ) e83484 2025.5

Nephronophthisis and Retinitis Pigmentosa (Senior-Loken Syndrome) After Living-Donor Kidney Transplantation: Twelve-Year Follow-Up in a Young Woman Reviewed

Toshihiko Matsuo, Yasuhiro Onishi, Hiroshi Morinaga, Jun Wada, Takehiro Tanaka, Motoo Araki

16 ( 5 ) 164 - 173 2025.5

Bilateral Scleritis and Neutrophilic Dermatosis With Cytogenetic Chromosomal Aberrancy Related to Pyoderma Gangrenosum: A Case Report of a 20-Year Follow-Up Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Noboru Asada, Mikako Obika, Ryotaro Omichi, Keiji Iwatsuki

Cureus 17 ( 4 ) e82348 2025.4

Presumed Autoimmune Keratitis in Both Eyes Without Systemic Manifestations: A 40-Year Course of a Patient With Corneal Infiltrates and Melt Reviewed

Toshihiko Matsuo, Takehiro Tanaka

Cureus 17 ( 2 ) e79852 2025.3

A Natural Course From Primary Intraocular Lymphoma to Brain Lymphoma in Four Years According to Patient's Choice Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Joji Ishida, Shotaro Kondo, Ken-ichi Matsuoka

Cureus 17 ( 3 ) e81476 2025.3

Eyelid Spindle Cell Lipoma: Case Report and Review of Three Patients in Literature Reviewed

Toshihiko Matsuo, Kiyoshi Yamada, Yasumasa Monobe, Takehiro Tanaka

Clinical Case Reports 13 ( e70097 ) 1 - 4 2025.1

Local Control of Conjunctival Malignant Melanoma by Proton Beam Therapy in a Patient With No Metastasis in Six Years From in Situ to Nodular Lesions. Reviewed

Toshihiko Matsuo, Takeshi Ogata, Takahiro Waki, Takehiro Tanaka, Kota Tachibana, Tomokazu Fuji, Takuya Adachi, Osamu Yamasaki

Journal of Medical Cases 16 ( 1 ) 28 - 36 2025.1

Perspectives of traditional herbal medicines in treating retinitis pigmentosa Reviewed

Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe, Jinghua Chen, Chi Sun, Qing Zhao

Frontiers in Medicine 11 ( 1468230 ) 2024.12

Axillary Reactive Lymphoid Hyperplasia, Likely Due to Unicentric Castleman Disease, and the Concurrent Presence of Orbital Mucosa- Associated Lymphoid Tissue (MALT) Lymphoma: A Six-Year Follow-Up Study. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Tomokazu Fuji, Daisuke Ennishi

Cureus 16 ( 11 ) e73775 2024.11

Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature Reviewed

Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

Cureus 16 ( 11 ) e74873 2024.11

Presumed Choroidopathy of IgG4-Related Disease Discovered During 16-Year Follow-Up of a Patient With Polycystic Kidney Disease. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Kenji Tsuji

Cureus 16(10) ( e70865 ) 1 - 5 2024.10

Intravitreal Fluconazole Injection for Fungal Endophthalmitis as Treatment Option in a Patient With End-Stage Liver and Kidney Diseases. Reviewed

Toshihiko Matsuo, Yasuyuki Kobayashi, Shingo Nishimura, Naoko Yoshioka, Yasushi Takahashi, Yasutaka Iguchi

Journal of Medical Cases 15 ( 11 ) 359 - 366 2024.10

Pathological findings in enucleated eyes of patients with neurofibromatosis type 1: report of a case with 15-year follow-up and review of 14 patients in the literature. Reviewed

Toshihiko Matsuo, Kenji Nishida, Takehiro Tanaka, Takaya Seno, Kiyoshi Yamada, Shigeki Ono

BMC Ophthalmology 24 ( 341 ) 1 - 13 2024.8

Anterior Uveitis After Discontinuation of Janus Kinase Inhibitor, Ruxolitinib Reviewed

Toshihiko Matsuo, Naoto Ikeda, Yasumasa Monobe, Takehiro Tanaka

Journal of Medical cases 15 ( 8 ) 208 - 214 2024.8

Genome-Wide Association Study with Three Control Cohorts of Japanese Patients with Esotropia and Exotropia of Comitant Strabismus and Idiopathic Superior Oblique Muscle Palsy Reviewed

Toshihiko Matsuo, Ichiro Hamasaki, Yoichiro Kamatani, Takahisa Kawaguchi, Izumi Yamaguchi, Fumihiko Matsuda, Akira Saito, Kazuyuki Nakazono, Shigeo Kamitsuji

International Journal of Molecular Sciences 25 ( 6986 ) 1 - 25 2024.6

Decades of stability of conjunctival vascular malformations in two patients. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Yoshihiro Kimata

Clinical Case Reports 12 ( e8933 ) 1 - 7 2024.5

Spontaneous regression and rare relapse after excisional biopsy in long-term observation of 31 patients with primary conjunctival lymphoma. Reviewed

Toshihiko Matsuo, Takehiro Tanaka

Journal of Clinical and Experimental Hematopathology 64 ( 2 ) 86 - 96 2024.5

Pericardial Effusion in Association With Periodontitis: Case Report and Review of 8 Patients in Literature. Reviewed

Toshihiko Matsuo, Chie Nakago Matsuo, Nobuhiko Matsuo, Ayano Mori, Masaaki Murakami, Hiroshi Ito

Journal of Investigative Medicine High Impact Case Reports 12 ( 23247096241239559 ) 1 - 8 2024.3

Vogt-Koyanagi- Harada disease in pregnancy: Case report and review of 32 patients in the literature. Reviewed

Toshihiko Matsuo, Kasumi Takahashi, Tsunemasa Kondo

Clinical Case Reports 12 ( e8643 ) 1 - 12 2024.3

sarcoidosis-lymphoma 症候群 Invited

松尾俊彦

「別冊日本臨床血液症候群（第3版）IV その他の血液疾患を含めて 29 413 - 417 2024.2

Rare Combination of Abducens Nerve Palsy and Optic Neuritis on the Same Side: Case Report and Review of 8 Patients in Literature. Reviewed

Toshihiko Matsuo, Daisuke Iguchi

Journal of Investigative Medicine High Impact Case Reports 12 ( 23247096231225873 ) 1 - 7 2024.1

Morphometric Analysis of the Eye by Magnetic Resonance Imaging in MGST2-Gene-Deficient Mice. Reviewed

Chaomulige, Toshihiko Matsuo, Kohei Sugimoto, Mary Miyaji, Osamu Hosoya, Masashi Ueda, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada

Biomedicines 12 ( 370 ) 1 - 14 2024.1

[Relapsed primary central nervous system lymphoma treated with CD19 chimeric antigen receptor T-cell therapy and allogeneic hematopoietic stem cell transplantation]. Reviewed

Fuminari Fujii, Toshiki Terao, Hisakazu Nishimori, Kentaro Fujii, Toshihiko Matsuo, Tadashi Yoshino, Hiroko Ueda, Tadashi Oyama, Akifumi Matsumura, Kaho Kondo, Chisato Matsubara, Kanako Fujiwara, Keisuke Seike, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Keiko Fujii, Nobuharu Fujii, Ken-Ichi Matsuoka, Yoshinobu Maeda

[Rinsho ketsueki] The Japanese journal of clinical hematology 65 ( 7 ) 622 - 627 2024

Language：Japanese Publishing type：Research paper (scientific journal)

Relapsed and/or refractory (R/R) primary central nervous system lymphoma (PCNSL) has a poor prognosis. A 57-year-old man diagnosed with PCNSL achieved a complete response by high-dose methotrexate-based chemotherapy followed by autologous hematopoietic stem cell transplantation (ASCT). The disease was not cured, so he was treated with the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel after the third relapse. However, the disease relapsed again 28 days after CAR T-cell therapy. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was attempted as curative therapy after bridging with second ASCT and tirabrutinib monotherapy. Although a temporary response was achieved, the disease relapsed 98 days after allo-HSCT. While receiving tirabrutinib for relapse after allo-HSCT, the patient developed acute respiratory failure due to transplant-related toxicity and post-transplant thrombotic microangiopathy. He died 175 days after allo-HSCT. Although various treatments for PCNSL have been investigated in recent years, the treatment strategy for R/R PCNSL has not been established. Further studies are warranted to improve the outcomes of patients with R/R PCNSL.

DOI： 10.11406/rinketsu.65.622

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特集指定難病 Up to Date 網膜色素変性症 Invited Reviewed

松尾俊彦

岡山医学会雑誌 135 ( 3 ) 147 - 151 2023.12

Nontuberculous mycobacterial abscess of lacrimal sac and eyelid debridement: Case report Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Kiyoshi Yamada, Motoko Nose, Yasushi Tanimoto

Clinical Case Reports 11 ( e8364 ) 1 - 6 2023.12

A simple method for culturing Acanthamoeba from soft contact lens at a clinical laboratory of a hospital: Case report of Acanthamoeba keratitis. Reviewed

Toshihiko Matsuo, Motoko Nose

Clinical Case Reports 11 ( e8248 ) 1 - 5 2023.11

Resection of Orbital Myxoma With Magnetic Resonance Imaging Evidence of Ethmoid Sinus Origin: Case Report and Review of 20 Patients in the Literature. Reviewed

Toshihiko Matsuo, Takehiro Tanaka

Journal of Investigative Medicine High Impact Case Reports 11 ( 10.1177/23247096231201013 ) 1 - 6 2023.9

Bilateral lacrimal gland mantle cell lymphoma in 11-year follow-up: case report and review of 48 cases with ocular adnexal presentation in the literature. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Kazuya Okada, Kenji Notohara, Keiko Fujii, Nobuharu Fujii

Journal of Investigative Medicine High Impact Case Reports 11 ( 23247096231185483 ) 2023.7

Bilateral Optic Neuritis and Hypophysitis With Diabetes Insipidus 1 Month After COVID-19 mRNA Vaccine: Case Report and Literature Review Reviewed

Toshihiko Matsuo, Kohei Okubo, Hirofumi Mifune, Takeshi Imao

Journal of Investigative Medicine High Impact Case Reports 11 ( 23247096231186046 ) 1 - 10 2023.7

ANCA-associated vasculitis with scleritis, corneal melt, and perforation rescued by rituximab: Case report and literature review Reviewed

Toshihiko Matsuo, Sumie Hiramatsu-Asano, Hiroshi Sawachika, Hirotake Nishimura

Clinical Case Reports 11 ( e7595 ) 1 - 8 2023.6

両側涙腺原発マントル細胞リンパ腫に対する末梢血幹細胞移植後10年診た1例

松尾俊彦, 田中健大, 岡田和也, 能登原憲司, 藤井敬子, 藤井伸治

日本リンパ網内系学会会誌 63 126 - 126 2023.6

Revisitng cyptocyanine dye, NK-4, as an old and new drug: review and future perspectives. Reviewed

Shuihui Liu, Toshihiko Matsuo, Takumi Abe

Internnational Journal of Molecular Sciences 24 ( 4411 ) 1 - 14 2023.2

Revisiting Cryptocyanine Dye, NK-4, as an Old and New Drug: Review and Future Perspectives

Shihui Liu, Toshihiko Matsuo, Takumi Abe

International Journal of Molecular Sciences 2023.2

Are Prophylactic Systemic Antibiotics Required in Patients with Cataract Surgery at Local Anesthesia? Reviewed

Toshihiko Matsuo, Masahiro Iguchi, Noriyasu Morisato, Tatsuya Murasako, Hideharu Hagiya

International Journal of Environmental Research and Public Health 19 ( 15796 ) 1 - 8 2022.11

Temporal association of vitreous hemorrhage and hypertension after COVID- 19 mRNA vaccines. Reviewed

Toshihiko Matsuo, Hiroshi Noda

Clinical Case Reports 10 ( e06657 ) 1 - 3 2022.11

Traditional Chinese Medicines and Prescriptions Brought from China to Japan by a Monk (Jianzhen, Japanese: Ganjin): A Historical Review Reviewed

Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe

Compounds 2 ( 4 ) 267 - 284 2022.10

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

(1) Background: Japanese Kampo medicine has its origin in ancient Chinese medicine. In 742, a Tang Dynasty monk named Jianzhen (Ganjin) was invited by Japanese clerics to visit Japan and teach commandments in Buddhism. Because of the dangers of the voyage and also other obstacles, he took 11 years to reach Japan on the sixth voyage and he was blind when he arrived in Japan. He was the first person in China to go to Japan to establish the Buddhism commandments, and he was also the first person in Japan to directly teach traditional Chinese medicine. Until now, there have been few reports in English about the details of the Chinese herbal medicines he brought to Japan, including the types of herbal medicines, pharmacological activities, and formulations. In the review, we systematically and comprehensively summarized Jianzhen’s life from the standpoint of his medical and pharmaceutical knowledge and the types and pharmacological activities of Chinese herbal medicines and prescriptions that were brought to Japan by Jianzhen; (2) Methods: A review was made on the relevant literature written by Chinese, Japanese, and English languages regarding the medical and pharmacological knowledge of Jianzhen, the 36 Chinese herbal medicines brought to Japan by Jianzhen, and the pharmacological and therapeutic effects of these 36 herbal medicines, as well as their formulations; (3) Results: The review of the literature proved that Jianzhen’s prescriptions served as a basis for current herbal medicines (Kampo) in Japan. In the process of the literature search, we found a book entitled Jianshangren (Holy Priest Jianzhen)’s Secret Prescription, which recorded the complete prescription of the 36 traditional Chinese medicines Jianzhen brought to Japan; (4) Conclusions: Jianzhen is one of the ancestors of traditional Chinese medicine/Kampo medicine, and he brought traditional Chinese medicine and medical books to Japan for patients. He made important contributions to the development of traditional Chinese medicine in Japan.

File： compounds-02-00022.pdf

DOI： 10.3390/compounds2040022

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Diffuse large B-cell lymphoma in the course of systemic sarcoidosis: A case report and review of 30 Japanese patients with sarcoidosis-lymphoma syndrome. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Rika Omote, Toshiaki Okada, Kenji Notohara, Kazuya Okada

Journal of Clinical and Experimental Hematopathology 62 ( 4 ) 22 - 237 2022.9

Candidate Genes in Testing Strategies for Linkage Analysis and Bioinformatic Sorting of Whole Genome Sequencing Data in Three Small Japanese Families with Idiopathic Superior Oblique Muscle Palsy Reviewed

Toshihiko Matsuo, Chaomulige, Mary Miyaji, Osamu Hosoya, Akira Saito, Kazuyuki Nakazono

International Journal of Molecular Sciences 23 ( 8626 ) 1 - 16 2022.8

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Idiopathic superior oblique muscle palsy is a major type of paralytic, non-comitant strabismus and presents vertical and cyclo-torsional deviation of one eye against the other eye, with a large vertical fusion range and abnormal head posture such as head tilt. Genetic background is considered to play a role in its development, as patients with idiopathic superior oblique muscle palsy have varying degrees of muscle hypoplasia and, rarely, the complete absence of the muscle, that is, aplasia. In this study, whole genome sequencing was performed, and single nucleotide variations and short insertions/deletions (SNVs/InDels) were annotated in two patients each in three small families (six patients in total) with idiopathic superior oblique muscle palsy, in addition to three normal individuals in one family. At first, linkage analysis was carried out in the three families and SNVs/InDels in chromosomal loci with negative LOD scores were excluded. Next, SNVs/InDels shared by the six patients, but not by the three normal individuals, were chosen. SNVs/InDels were further narrowed down by choosing low-frequency (<1%) or non-registered SNVs/InDels in four databases for the Japanese population, and then by choosing SNVs/InDels with functional influence, leading to one candidate gene, SSTR5-AS1 in chromosome 16. The six patients were heterozygous for 13-nucleotide deletion in SSTR5-AS1, except for one homozygous patient, while the three normal individuals were wild type. Targeted polymerase chain reaction (PCR) and direct sequencing of PCR products confirmed the 13-nucleotide deletion in SSTR5-AS1. In the face of newly-registered SSTR5-AS1 13-nucleotide deletion at a higher frequency in a latest released database for the Japanese population, the skipping of low-frequency and non-registration sorting still resulted in only 13 candidate genes including SSTR5-AS1 as common variants. The skipping of linkage analysis also led to the same set of 13 candidate genes. Different testing strategies that consisted of linkage analysis and simple unintentional bioinformatics could reach candidate genes in three small families with idiopathic superior oblique muscle palsy.

File： SO palsy WGS final ijms-23-08626.pdf

DOI： 10.3390/ijms23158626

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CD19 immunostaining of a stored paraffin-embedded vitrectomy cell block of intraocular lymphoma contributing to chimera antigen receptor T-cell therapy. Reviewed

Matsuo T, Tanaka T, Fujii N, Fujii K, Kondo E

Journal of Clinical and Experimental Hematopathology 62 ( 3 ) 187 - 189 2022.8

Photorefraction with Spot Vision Screener versus Visual Acuity Testing as Community-Based Preschool Vision Screening at the Age of 3.5 Years in Japan

Toshihiko Matsuo, Chie Matsuo, Masami Kayano, Aya Mitsufuji, Chiyori Satou, Hiroaki Matsuoka

International Journal of Environmental Research and Public Health 19 ( 8655 ) 1 - 15 2022.7

人工臓器の最前線vol.3「光電変換色素薄膜型の人工網膜OUReP（オーレップ） Invited

松尾俊彦, 内田哲也, 石金浩史

医学のあゆみ 282 ( 4 ) 304 - 312 2022.7

モンゴル伝統医学とその現代的意義

梶井一暁, 包雪峰, 朝木力格, 松尾俊彦, 白烏日罕

岡山大学大学院教育学研究科研究集録 180 ( 1 ) 1 - 8 2022.6

サルコイドーシス経過中にびまん性大細胞B細胞リンパ腫を発症した1例

松尾俊彦, 田中健大, 表梨華, 岡田俊明, 能登原憲司, 岡田和也

日本リンパ網内系学会会誌 62 93 - 93 2022.6

Whole exome-sequencing of pooled genomic DNA samples to detect quantitative trait loci in esotropia and exotropia of stra-bismus in Japanese. Reviewed

Zhang J, Matsuo T, Hamasaki I, Sato K

Life 12 ( 41 ) 1 - 12 2022.1

Proton Beam Therapy Followed by Pembrolizumab for Giant Ocular Surface Conjunctival Malignant Melanoma: Case Report. Reviewed

Matsuo T, Yamasaki O, Tanaka T, Katsui K, Waki T

Molecular and Clinical Oncology 16 ( 12 ) 1 - 5 2022.1

COVID-19 mRNA Vaccine–Associated Uveitis Leading to Diagnosis of Sarcoidosis: Case Report and Review of Literature Reviewed International journal

Toshihiko Matsuo, Hiroyuki Honda, Takehiro Tanaka, Kensuke Uraguchi, Masaaki Kawahara, Hideharu Hagiya

Journal of Investigative Medicine High Impact Case Reports 10 232470962210864 - 232470962210864 2022.1

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. The patient, however, continued to have fever and malaise and showed a high level of serum soluble interleukin-2 receptor (sIL-2R) even 4 weeks after the second vaccination. Computed tomographic scan disclosed mediastinal and bilateral hilar small lymphadenopathy together with limited granular lesion in the right lung. Gallium-67 scintigraphy demonstrated high uptake not only in mediastinal and hilar lymph nodes but also in bilateral parotid glands. Right parotid gland biopsy revealed noncaseating granulomas and proved pathological diagnosis of sarcoidosis. The systemic symptoms were relieved by oral prednisolone 20 mg daily. Even though the causal relationship remains undetermined, this case is unique at the point that vaccine-associated uveitis led to the detection of pulmonary lesions and lymphadenopathy, resulting in clinical and pathological diagnosis of sarcoidosis. In literature review, 3 patients showed sarcoidosis-like diseases after COVID-19 vaccination: 2 patients were diagnosed clinically as Lofgren syndrome with acute onset of erythema nodosum and ankle swelling, with or without mediastinal and hilar lymphadenopathy, whereas 1 patient with mediastinal lymphadenopathy but no uveitis was diagnosed pathologically by biopsy as sarcoidosis.

File： JIM High Inpact CaseRep Coronavirus vacciation.pdf

DOI： 10.1177/23247096221086450

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Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/23247096221086450

Effect of NK-5962 on Gene Expression Profiling of Retina in a Rat Model of Retinitis Pigmentosa Reviewed

Shihui Liu, Mary Miyaji, Osamu Hosoya, Toshihiko Matsuo

International Journal of Molecular Sciences 22 ( 13276 ) 1 - 16 2021.12

Diffuse large B-cell lymphoma 18 years after bilateral lacrimal gland IgG4-related disease: case report and literature review. Reviewed

Matsuo T, Tanaka T, Notohara K, Okada K

Journal of Investigative Medicine High Impact Case Reports 10 ( DOI:10.1177/23247096211067894 ) 1 - 10 2021.12

Bilateral Optic Disc Swelling as a Plausible Common Ocular Sign of Autoinflammatory Diseases: Report of Three Patients with Blau Syndrome or Cryopyrin-Associated Periodic Syndrome. Reviewed International journal

Toshihiko Matsuo, Masato Yashiro, Osamu Yamasaki, Takehiro Tanaka, Akira Manki

Life (Basel, Switzerland) 11 ( 1433 ) 2021.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The aim of this study is to describe bilateral optic disc swelling in three consecutive patients with Blau syndrome or cryopyrin-associated periodic syndrome at a single institution. Case 1 was a 30-year-old woman receiving 25 mg etanercept twice weekly who had been diagnosed as early-onset sarcoidosis by biopsy of skin rashes at 5 months old and genetically diagnosed with Blau syndrome with CARD15/NOD2 mutation (N670K) at 13 years old. At 10 years old, she began to have uveitis with optic disc swelling in both eyes, resulting in macular degeneration and optic disc atrophy at 17 years old only when etanercept was introduced. Case 2 was a 21-year-old man receiving adalimumab every 2 weeks who had been diagnosed as early-onset sarcoidosis by biopsy of skin rashes at 1.5 years old and genetically diagnosed as Blau syndrome with CARD15/NOD2 mutation (C495Y) at 5 years old. At 8 years old, around the time of adalimumab introduction, he began to show bilateral optic disc swelling which continued until the age of 16 years when the dose of adalimumab was increased. Case 3 was a 20-year-old woman receiving canakinumab every 8 weeks for systemic symptoms such as fever, headache, vomiting, and abdominal pain and later for sensorineural hearing disturbance on both sides. She had been diagnosed genetically with cryopyrin-associated periodic syndrome with NLRP3 mutation (Y859C) at 7 years old. At 5 years old, she was found to have bilateral optic disc swelling, which continued until the age of 10 years when she began receiving canakinumab (IL-1β inhibitor). Bilateral optic disc swelling might be tentatively designated as a plausible common ocular feature, if it occurred, in autoinflammatory diseases to pay more attention to ophthalmic complications in rare diseases.

File： life-11-01433.pdf

DOI： 10.3390/life11121433

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Whole Exome-Sequencing of Pooled Genomic DNA Samples to Detect Quantitative Trait Loci in Esotropia and Exotropia of Strabismus in Japanese

Jingjing Zhang, Toshihiko Matsuo, Ichiro Hamasaki, Kazuhiro Sato

Life 2021.12

Clarification of degradation mechanism on retinal prosthesis using photoelectric dyes coupled to polyethylene film by mass spectrometry. Reviewed

Koichiro Yamashita, Mayu Mitui, Toshihiko Matsuo, Tetsuya Uchida

Materials Letters 307(2022) ( 130978 ) 1 - 4 2021.10

Accuracy of deep learning algorithms for the diagnosis of retinopathy of prematurity by fundus images: systematic review and meta-analysis. Reviewed

Jingjing Zhang, Yangyang Liu, Toshiharu Mitsuhashi, Toshihiko Matsuo

Journal of Ophthalmology 2021 ( 8883946 ) 1 - 11 2021.8

Alcohol Consumption and Age related Macular Degeneration: A Systematic Review and Dose response Meta analysis. Reviewed

Jingjing Zhang, Toshiharu Mitsuhashi, Toshihiko Matsuo, Takashi Yorifuji, Jun Hamada, Yangyang Liu

Current Eye Research 2021.7

The Effect of Cyanine Dye NK-4 on Photoreceptor Degeneration in a Rat Model of Early-Stage Retinitis Pigmentosa Reviewed

Shihui Liu, Toshihiko Matsuo, Mary Miyaji, Osamu Hosoya

Pharmaceuticals 14 ( 694 ) 1 - 14 2021.7

Photoelectric Dye, NK-5962, as a Potential Drug for Preventing Retinal Neurons from Apoptosis: Pharmacokinetic Studies Based on Review of the Evidence. Reviewed International journal

Toshihiko Matsuo, Shihui Liu, Tetsuya Uchida, Satomi Onoue, Shinsaku Nakagawa, Mayumi Ishii, Kayoko Kanamitsu

Life (Basel, Switzerland) 11 ( 591 ) 1 - 19 2021.6

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

NK-5962 is a key component of photoelectric dye-based retinal prosthesis (OUReP). In testing the safety and efficacy, NK-5962 was safe in all tests for the biological evaluation of medical devices (ISO 10993) and effective in preventing retinal cells from death even under dark conditions. The long-term implantation of the photoelectric dye-coupled polyethylene film in the subretinal space of hereditary retinal dystrophic (RCS) rats prevented neurons from apoptosis in the adjacent retinal tissue. The intravitreous injection of NK-5962 in the eyes of RCS rats, indeed, reduced the number of apoptotic cells in the retinal outer nuclear layer irrespective of light or dark conditions. In this study, we reviewed the in vitro and in vivo evidence of neuroprotective effect of NK-5962 and designed pharmacokinetic experiments. The in vitro IC50 of 1.7 μM, based on the protective effect on retinal cells in culture, could explain the in vivo EC50 of 3 μM that is calculated from concentrations of intravitreous injection to prevent retinal neurons from apoptosis. Pharmacokinetics of NK-5962 showed that intravenous administration, but not oral administration, led to the effective concentration in the eye of rats. NK-5962 would be a candidate drug for delaying the deterioration of retinal dystrophy, such as retinitis pigmentosa.

File： life-11-00591.pdf

DOI： 10.3390/life11060591

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Prostate cancer detected by choroidal tumor and complete response to hormonal therapy: Case report and literature review of 24 patients with choroidal metastasis from prostate cancer. Reviewed

Matsuo T, Tanaka T, Nakamura A, Wada K

Journal of Investigative Medicine High Impact Case Reports 9 ( 23247096211026471 ) 1 - 8 2021.6

両側涙腺IgG4関連疾患の18年後に発症した全身のびまん性大細胞B細胞リンパ腫

松尾俊彦, 田中健大, 岡田和也, 能登原憲司

日本リンパ網内系学会会誌 61 91 - 91 2021.5

Development and chemical properties of retinal prostheses using photoelectric dyes coupled to polyethylene films with various anions to achieve high durability. Reviewed

Yamashita K, Tanaka T, Matsuo T, Uchida T

Polymer Journal 53 719 - 729 2021.4

Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film. Reviewed

Koichiro Yamashita, Prathima Sundaram, Tetsuya Uchida, Toshihiko Matsuo, Willy Wong

Journal of Neural Engineering 18 ( 045006 ) 1 - 14 2021.4

Development of highly durable retinal prosthesis using photolectric dyes coupled to polyethylene film and quantitative in vitro evaluation of its durability. Reviewed

Yamashita K, Tanaka T, Matsuo T, Uchida T

Biomedical Materials 16 ( 4 ) 045001 2021.4

Television-watching in the early years of life and the association with parents’ concerns about decreased visual acuity in their elementary school-aged child: results of a nationwide population-based longitudinal survey of Japan. Reviewed

Matsuo T, Yorifuji T

Japanese Journal of Ophthalmology 65 561 - 568 2021.3

Follow-up with serum IgG4-monitoring in 8 patients with IgG4-related disease diagnosed by a lacrimal gland mass. Reviewed

Toshihiko Matsuo, Takehiro Tanaka, Yasuharu Sato, Hitomi Kataoka, Mayu Uka, Daisuke Ennishi, Tomofumi Yano

Journal of clinical and experimental hematopathology : JCEH 61 ( 1 ) 10 - 21 2021.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

The diagnostic criteria for IgG4-related disease were previously published and serum IgG4 measurement has been reimbursed by national health insurance in Japan since 2012. Eight patients diagnosed with IgG4-related disease based on lacrimal gland masses were retrospectively reviewed. The 8 patients were 3 men and 5 women ranging in age from 52 to 77 (median, 63) years at the initial visit and their follow-up period ranged from 0.25 to 11 (median, 7) years. Bilateral and unilateral involvement were noted in 4 patients each; 2 on the right side and 2 on the left side in those with unilateral involvement. Serum IgG4 was high in 5 of 8 patients at the initial visit. Five patients with no systemic signs were followed without treatment, whereas oral steroids were administered and tapered in the other 3 patients who exhibited systemic signs. One patient with a history of radiation for MALT lymphoma in bilateral lacrimal glands developed IgG4-related disease in the left lacrimal gland 10 years later and was followed without treatment. Nine years later, her serum IgG4 level increased to 1500 mg/dL and paracardiac lesions, found on positron emission tomography, were confirmed to be MALT lymphoma by needle biopsy, leading to systemic chemotherapy. The other 7 patients had neither local recurrence nor additional systemic signs. Serum IgG4 monitoring may be useful to detect systemic complications in IgG4-related ophthalmic disease and markedly high serum IgG4 levels may indicate new lymphoma at other sites.

File： JCEH IgG42021.pdf

DOI： 10.3960/jslrt.20048

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「2-12. 人工網膜」テクノロジー・ロードマップ2021-2030 医療・健康・食農編 Invited

松尾俊彦, 内田哲也

テクノロジー・ロードマップ2021-2030 医療・健康・食農編日経BP 226 - 229 2021.2

Photoelectric dye-based retinal prosthesis (OUReP) as a novel type of artificial retina Invited Reviewed

Toshihiko Matsuo, Tetsuya Unchida

Internal Medicine Review 7 ( 1(916) ) 1 - 17 2021.1

Pathologically-proven intraocular infiltration with adult T-cell leukemia/lymphoma: two new cases with either vitreous opacity or aqueous hypopyon and literature review of 16 cases. Reviewed

Matsuo T, Shimizu T, Tanaka T, Yamamoto A, Takasuka H

Journal of Investigative Medicine High Inpact Case Reports 8 1 - 8 2020.10

Curved-Tip Disposable Injector (OUReP Injector) to Insert Photoelectric Dye-Coupled Polyethylene Film (OUReP) as Retinal Prosthesis into Subretinal Space of Rabbit Eyes. Reviewed

Toshihiko Matsuo, Chie Matsuo, Tetsuya Uchida, Koichiro Yamashita, Tenu Tanaka, Yusuke Kawakami, Toshiya Hitomi, Kanji Taga, Tatsuya Sanada, Yusuke Yamashita

Journal of Surgical Techniques and Procedures 4 ( 1040 ) 1 - 6 2020.9

Long-term control of macular edema with adalimumab after cataract surgery in a Japanese child with juvenile idiopathic arthritis: case report and review of 26 Japanese patients. Reviewed

Toshihiko Matsuo, Masato Yashiro

Journal of Investigative Medicine High Inpact Case Reports 8 1 - 10 2020.8

Step-by-Step Procedure to Test Photoelectric Dye-Coupled Polyethylene Film as Retinal Prosthesis to Induce Light-Evoked Spikes in Isolated Retinal Dystrophic Tissue of rd1 Mice. Reviewed

Matsuo T, Terada K, Sakurai M, Liu S, Yamashita K, Uchida T

Clinics in Surgery 5 ( 2903 ) 1 - 9 2020.8

Interview オール岡山の技術が光を取り戻す！－いよいよ最終段階に来た人工網膜とは Invited

松尾俊彦, 内田哲也

Optronics 463 124 - 129 2020.7

涙腺腫脹でIgG4関連疾患と診断された6例の血清IgG4値による長期経過観察

松尾俊彦, 田中健大, 佐藤康晴, 片岡仁美, 宇賀麻由, 遠西大輔, 矢野朋文

日本リンパ網内系学会会誌 60 92 - 92 2020.7

The timing for diagnosis of anisometropia in Japanese children with congenital eyelid ptosis. Reviewed

Toshihiko Matsuo

5 ( 2842 ) 1 - 3 2020.6

Superior conjunctiva-sparing intraocular lens-suturing technique with straight long suture needles advanced from the opposite side. Reviewed

Toshihiko Matsuo

Clinics in Surgery 5 ( 2847 ) 1 - 5 2020.6

特集：人工視覚の現状と展望「色素結合薄膜型の人工網膜OUReP（オーレップ）」 Invited

松尾俊彦, 内田哲也

光アライアンス 31 ( 7 ) 13 - 18 2020

Are there primary intraocular lymphomas that do not develop into central nervous system lymphomas? Reviewed

Toshihiko Matsuo, Takehiro Tanaka

Journal of clinical and experimental hematopathology : JCEH 59 ( 4 ) 168 - 174 2019.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Primary intraocular lymphomas frequently develop into central nervous system lymphomas and vice versa. This study reviewed 22 consecutive patients with primary intraocular lymphoma diagnosed by immunostaining of vitrectomy cell blocks, and examined whether they developed central nervous system lymphoma. Seventeen patients developed central nervous system lymphoma: 3 patients developed intraocular and central nervous system lymphoma simultaneously, 9 patients developed central nervous system lymphoma 1 month to 5 years (median, 3 months) after intraocular lymphoma, and 5 patients developed central nervous system lymphoma preceding the diagnosis of intraocular lymphoma by 3 months to 9 years and 8 months (median, 1.5 years). In contrast, 5 patients did not develop central nervous system lymphoma: 2 patients did not develop local recurrence or central nervous system lymphoma in the follow-up period of 5 years and 11 years, respectively, after vitrectomy alone without additional local or systemic treatment. The remaining 3 patients with intraocular lymphoma had insufficient follow-up periods to determine the prognosis. The results of CD5 immunostaining of vitrectomy specimens were found in pathology reports of 8 patients: 3 patients with CD5-positive large cells and 4 patients with CD5-negative large cells developed central nervous system lymphoma. In summary, only a small number of patients did not develop central nervous system lymphoma based on long-term follow-up after vitrectomy alone. CD5 was not a marker of central nervous system involvement in this study population.

File： JCEH2019final intraocular lymphma.pdf

DOI： 10.3960/jslrt.19019

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Lacrimal Sac Malignant Melanoma in 15 Japanese Patients: Case Report and Literature Review. Reviewed

Matsuo T, Tanaka T, Yamasaki O

Journal of investigative medicine high impact case reports 7 2324709619888052 2019.1

Vision evaluation by functional observational battery, operant behavior test, and light/dark box test in retinal dystrophic RCS rats versus normal rats Reviewed

Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Atsushi Fujiwara, Masahiko Iino, Masao Oguchi

HELIYON 5 ( e01936 ) 2019

Photoelectric Dye-Coupled Polyethylene Film: Photoresponsive Properties Evaluated by Kelvin Probe and In Vitro Biological Response Detected in Dystrophic Retinal Tissue of Rats Reviewed

Toshihiko Matsuo, Mikako Sakurai, Keiko Terada, Tetsuya Uchida, Koichiro Yamashita, Tenu Tanaka, Kenichi Takarabe

ADVANCED BIOMEDICAL ENGINEERING 8 137 - 144 2019

Long-term outcome in 7 patients with idiopathic orbital myositis. Reviewed

Matsuo T

Japanese Clinical Medicine 10 1 - 5 2019

Intraocular lymphoma as relapse after chemotherapy for primary breast diffuse large B-cell lymphoma.

Toshihiko Matsuo, Takehiro Tanaka, Tomofumi Yano

Journal of clinical and experimental hematopathology : JCEH 58 ( 4 ) 180 - 183 2018.12

Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye-Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration. Reviewed

Matsuo T, Uchida T, Sakurai J, Yamashita K, Matsuo C, Araki T, Yamashita Y, Kamikawa K

Artificial organs 42 ( 8 ) E186 - E203 2018.8

Visual evoked potential in rabbits’ eyes with subretinal implantation by vitrectomy of Okayama university-type retinal prosthesis (OURePTM) Reviewed

Toshihiko Matsuo, Tetsuya Uchida, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

Journal of Veterinary Medical Science 80 ( 2 ) 247 - 259 2018.2

MGST2 and WNT2 are candidate genes for comitant strabismus susceptibility in Japanese patients Reviewed

Jingjing Zhang, Toshihiko Matsuo

PEERJ 5 ( e3935 ) e3935 2017.10

Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP (TM)) implantation Reviewed

Alamusi, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

JOURNAL OF ARTIFICIAL ORGANS 20 ( 2 ) 158 - 165 2017.6

Vogt-Koyanagi-Harada disease-like posterior uveitis in the course of nivolumab (anti-PD-1 antibody), interposed by vemurafenib (BRAF inhibitor), for metastatic cutaneous malignant melanoma. Reviewed

Matsuo T, Yamasaki O

Clinical case reports 5 ( 5 ) 694 - 700 2017.5

眼窩涙腺部腫瘍生検で木村病と確定した後にネフローゼ症候群を発症した1例

松尾俊彦, 田中健大, 木野村賢

日本リンパ網内系学会会誌 57 109 - 109 2017.5

Photoelectric Dye Used for Okayama University-Type Retinal Prosthesis Reduces the Apoptosis of Photoreceptor Cells Reviewed

Shihui Liu, Toshihiko Matsuo, Osamu Hosoya, Tetsuya Uchida

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 33 ( 3 ) 149 - 160 2017.4

Positive bacterial culture in conjunctival sac before cataract surgery with night stay is related to diabetes mellitus Reviewed

Tetsuhiro Kawata, Toshihiko Matsuo

BMC OPHTHALMOLOGY 17 ( 1 ) 14 2017.2

Nephrotic syndrome during the tapering of oral steroids after pathological diagnosis of Kimura disease from a lacrimal gland mass: case report and review of 10 Japanese patients. Reviewed

Matsuo T, Tanaka T, Kinomura M

Journal of clinical and experimental hematopathology : JCEH 57 ( 3 ) 147 - 152 2017

Language：English Publishing type：Research paper (scientific journal)

A 42-year-old man with eosinophilia and high serum immunoglobulin E (IgE) developed a lacrimal gland mass on the left side. Excisional biopsy revealed hyperplasia of lymphoid follicles, and infiltration with lymphocytes and eosinophils around lacrimal gland acini, leading to the pathological diagnosis of Kimura disease. IgE-positive cells were mainly found along follicular dendritic cells, and a small number of IgG4-positive cells was present. One month after oral prednisolone was started at 40 mg daily and tapered to 10 mg daily, he developed lower leg edema on both sides and marked proteinuria (10.8 g/day). Renal biopsy showed no glomerular abnormalities, no immunoglobulin deposition, and no tubulointerstitial infiltration with eosinophils, leading to the diagnosis of minimal change nephrotic syndrome. Proteinuria subsided in response to an increased dose of prednisolone to 30 mg daily. Proteinuria relapsed three times in the following 5 years when oral prednisolone was tapered. In conclusion, Kimura disease manifested as an orbital mass and did not relapse. However, nephrotic syndrome relapsed frequently with background eosinophilia and high serum IgE. This study reviewed the clinical features of 10 Japanese patients with Kimura disease associated with proteinuria.

File： Kimura disease Matsuo.pdf

DOI： 10.3960/jslrt.17028

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Subretinal implantation of Okayama university-type retinal prosthesis (OURepTM) in canine eyes by vitrectomy Reviewed

Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa

Journal of Veterinary Medical Science 79 ( 12 ) 1939 - 1946 2017

Orbital MALT Lymphoma after Autologous Stem Cell Transplantation for Follicular Lymphoma as Relapse of Diffuse Large B-Cell Lymphoma. Reviewed

Matsuo T, Tanaka T, Fujii N

Journal of clinical and experimental hematopathology : JCEH 56 ( 3 ) 170 - 175 2017

Clinical decision upon resection or observation of ocular surface dermoid lesions with the visual axis unaffected in pediatric patients Reviewed

Toshihiko Matsuo

SPRINGERPLUS 4 ( 1 ) 534 2015.9

Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OUReP (TM)) implantation Reviewed

Alamusi, Toshihiko Matsuo, Osamu Hosoya, Kimiko M. Tsutsui, Tetsuya Uchida

JOURNAL OF ARTIFICIAL ORGANS 18 ( 3 ) 264 - 271 2015.9

How far is observation allowed in patients with ectopia lentis? Reviewed

Toshihiko Matsuo

SPRINGERPLUS 4 461 2015.8

Clinical factors underlying a single surgery or repetitive surgeries to treat superior oblique muscle palsy Reviewed

Kana Aoba, Toshihiko Matsuo, Ichiro Hamasaki, Kayoko Hasebe

SPRINGERPLUS 4 ( 166 ) 166 2015.4

Intraocular Relapse with Hypopyon and Retinal Infiltrates after Chemotherapy and Peripheral Blood Stem Cell Transplantation for Extranodal NK/T-Cell Lymphoma. Reviewed

Matsuo T, Tanaka T, Ichimura K, Meguri Y

Journal of clinical and experimental hematopathology : JCEH 55 ( 3 ) 157 - 161 2015

Oral infection control to assist infliximab therapy in a Behçet's disease patient with severe eye inflammation in response to dental treatment: a case report. Reviewed International journal

Kudo C, Wakabayashi H, Shimoe M, Kobayashi H, Ito T, Ohkawa T, Isoshima-Nakamura A, Mineshiba J, Yoshioka N, Nawachi K, Maeda H, Matsuo T, Makino H, Takashiba S

Clinical case reports 2 ( 6 ) 274 - 280 2014.12

Infective Endocarditis With Origin in Orbital Vascular Malformation and Maxillary Sinusitis: A Case Report and Review of Four Patients in the Literature Reviewed

Toshihiko Matsuo, Yoshitaka Iwamoto, Hironori Okamoto, Daisuke Iguchi

Cureus 16 ( 11 ) e74873 2014.12

Mantle cell lymphoma diagnosed by conjunctival salmon-pink lesion biopsy. Reviewed

Matsuo T, Ichimura K, Kubonishi S

Journal of clinical and experimental hematopathology : JCEH 54 ( 2 ) 143 - 147 2014

眼底綿花様白斑を合併した全身性エリテマトーデスの1例眼合併症と疾患活動性との関連性に関する検討

杉生真帆, 青山裕美, 梶田藍, 竹島千夏, 濱田利久, 松尾俊彦, 赤塚俊文, 岩月啓氏

臨床皮膚科 66 ( 12 ) 960 - 964 2012.11

MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

濱田利久, 鈴木大介, 竹島千夏, 三宅智子, 杉生真帆, 岩月啓氏, 松尾俊彦

Skin Cancer 26 ( 3 ) 387 - 387 2012.2

SLEに発症した網膜症(綿花様白斑)と疾患活動性との比較検討

杉生真帆, 梶田藍, 竹島千夏, 濱田利久, 青山裕美, 岩月啓氏, 松尾俊彦, 赤塚俊文

日本皮膚科学会雑誌 121 ( 11 ) 2278 - 2278 2011.10

MDSをともない、経過中に涙丘と骨髄浸潤をきたした芽球性形質細胞様樹状細胞腫瘍の1例

濱田利久, 鈴木大介, 竹島千夏, 三宅智子, 杉生真帆, 松尾俊彦, 岩月啓氏

日本皮膚悪性腫瘍学会学術大会プログラム・抄録集 27回 121 - 121 2011.6

Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses Reviewed

Miho Tamaki, Toshihiko Matsuo

Journal of Artificial Organs 14 ( 2 ) 140 - 150 2011

Erratum: Optical coherence tomographic parameters as objective signs for visual acuity in patients with retinitis pigmentosa, future candidates for retinal prostheses (Journal of Artificial Organs (2011) 14, (140-150) DOI: 10.1007/s10047-011-0557-9) Reviewed

Miho Tamaki, Toshihiko Matsuo

Journal of Artificial Organs 14 ( 4 ) 385 2011

脈絡膜黒色腫の病期、再発診断におけるFDG-PET/CTの初期経験

荻野裕香, 奥村能啓, 佐藤修平, 新家崇義, 原田聡介, 檜垣文代, 宗田由子, 山本岳玄, 加藤勝也, 郷原英夫, 平木隆夫, 三村秀文, 加地充昌, 松尾俊彦, 金澤右

日本医学放射線学会秋季臨床大会抄録集 46回 S530 - S530 2010.8

Immunoglobulin G4 (IgG4)-positive or -negative ocular adnexal benign lymphoid lesions in relation to systemic involvement. Reviewed

Matsuo T, Ichimura K, Sato Y, Tanimoto Y, Kiura K, Kanazawa S, Okada T, Yoshino T

Journal of clinical and experimental hematopathology : JCEH 50 ( 2 ) 129 - 142 2010

Language：English Publisher：The Japanese Society for Lymphoreticular Tissue Research

The purpose of this study is to determine the relationship of ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts of 9 consecutive patients with ocular adnexal benign lymphoid lesions, seen in the Department of Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections were restained immunohistochemically for IgG4-, IgG-, and CD138-positive plasma cells. The diagnosis of IgG4-positive lesions was based on 10 or more IgG4-positive plasma cells in a high-power field and greater than 40% ratios of IgG4-positive plasma cells/CD138-positive plasma cells and IgG4-positive plasma cells/IgG-positive plasma cells. IgG4-positive lesions were determined as absent in 5 patients (4 with bilateral lacrimal/orbital lesions and one with a unilateral conjunctival lesion), none of whom showed systemic manifestations. In contrast, IgG4-positive lesions were present in 4 patients (3 with bilateral lacrimal/orbital lesions and one with a unilateral lacrimal/orbital lesion), who showed systemic manifestations : one with Hashimoto thyroiditis, one with IgG4-positive bilateral interstitial lung disease and hepatic inflammatory pseudotumor, one with bilateral interstitial lung disease, and one with systemic lymphadenopathy and antiphospholipid syndrome. In conclusion, IgG4-positive ocular adnexal benign lymphoid lesions might be used as a benchmark for the probable presence of other systemic lymphoid lesions.

DOI： 10.3960/jslrt.50.129

Other Link： http://search.jamas.or.jp/link/ui/2011254628

A case of aplasia of inferior rectus muscle

Tomoko Watanabe, Toshihiko Matsuo, Takashi Furuse, Satoshi Hasebe, Toshihiro Yanagawa, Toshinari Shimizu, Hiroshi Ohtsuki

Japanese Journal of Clinical Ophthalmology 62 ( 8 ) 1309 - 1314 2008.8

Different histopathological types of orbital lymphoma 16 years after systemic follicular lymphoma: immunohistochemical and immunogenetic analyses of two cases. Reviewed

Matsuo T, Ichimura K, Shinagawa K, Yoshino T

Journal of clinical and experimental hematopathology : JCEH 48 ( 1 ) 17 - 24 2008.4

Language：English Publisher：The Japanese Society for Lymphoreticular Tissue Research

The purpose of this study is to show that the histopathological type of an orbital lymphoma can differ from the systemic follicular lymphoma that precedes it. A 44-year-old man (Patient #1) and a 50-year-old man (Patient #2) presented with generalized lymphadenopathy due to grade 1 follicular lymphoma proven on lymph node biopsy. Patient #1 was followed without treatment for 16 years when he developed a right orbital mass. Patient #2 underwent several courses of combination chemotherapy as well as radiation but relapsed. The second biopsy of the lymph node nine years later showed the same histopathological type of follicular lymphoma. He developed an orbital mass on the right side 16 years after the initial presentation. In Patient #1, excisional biopsy of the orbital masses showed extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In Patient #2, biopsy revealed the orbital mass to be T-cell/histiocyte-rich diffuse large B-cell lymphoma. In Patient #1, when comparing the original lymph node biopsy to the orbital biopsy obtained years later, no evidence for clonality was noted by polymerase chain reaction. In Patient #2, the amplification by polymerase chain reaction of the immunoglobulin heavy chain gene rearrangement in the lymph node lesion and the orbital lesion gave rise to a single discrete band with the same DNA sequence except for five nucleotide changes, indicating the same clonality in the presence of genomic changes. In conclusion, orbital lymphomas can occur as a second lymphoma with a different histopathological type in the long-term follow-up of systemic lymphomas. The original and subsequent lymphomatous lesions may or may not share neoplastic cell clonality and all genomics. [J Clin Exp Hematopathol 48(1) : 17-24, 2008]

DOI： 10.3960/jslrt.48.17

Other Link： http://search.jamas.or.jp/link/ui/2008264833

Clinical features, ARIX and PHOX2B nucleotide changes in three families with congenital superior oblique muscle palsy Reviewed

Sayuri Imai, Toshihiko Matsuo, Emi Itoshima, Hiroshi Ohtsuki

ACTA MEDICA OKAYAMA 62 ( 1 ) 45 - 53 2008.2

[Vision engineering--photoelectric dye-based retinal prostheses: Okayama University model]. Reviewed

Matsuo T

Brain and nerve = Shinkei kenkyu no shinpo 59 ( 4 ) 331 - 338 2007.4

Vision engineering - Photoelectric dye-based retinal prostheses: Okayama university model Reviewed

Toshihiko Matsuo

Brain and Nerve 59 ( 4 ) 331 - 338 2007.4

A low-vision-care viewpoint of cataract surgery for patients with retinitis pigmentosa

Noriko Morimoto, Toshihiko Matsuo, Hiroshi Ohtsuki

Folia Ophthalmologica Japonica 58 ( 3 ) 153 - 157 2007.3

Detection of strabismus and amblyopia in 1.5-and 3-year-old children by a preschool vision-screening program in Japan Reviewed

Toshihiko Matsuo, Chie Matsuo, Hiroaki Matsuoka, Keiko Kio

ACTA MEDICA OKAYAMA 61 ( 1 ) 9 - 16 2007.2

Prostaglandins F-2 alpha and E-2 in aqueous humor of patients with cataract surgery Reviewed

T Matsuo

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 20 ( 2 ) 101 - 106 2004.4

ARIX gene polymorphisms in patients with congenital superior oblique muscle palsy Reviewed

Y Jiang, T Matsuo, H Fujiwara, S Hasebe, H Ohtsuki, T Yasuda

BRITISH JOURNAL OF OPHTHALMOLOGY 88 ( 2 ) 263 - 267 2004.2

A Simple Method for Screening Photoelectric Dyes towards Their Use for Retinal Prostheses Reviewed

Toshihiko Matsuo

Acta Medica Okayama 57 ( 5 ) 257 - 260 2003.10

Clinical correlations of aggrecan in the resected medial rectus muscle of patients with intermittent exotropia Reviewed

T Yamane, T Matsuo, S Hasebe, H Ohtsuki

ACTA MEDICA OKAYAMA 57 ( 4 ) 199 - 204 2003.8

Genome-wide search for strabismus susceptibility loci Reviewed

H Fujiwara, T Matsuo, M Sato, T Yamane, M Kitada, S Hasebe, H Ohtsuki

ACTA MEDICA OKAYAMA 57 ( 3 ) 109 - 116 2003.6

Multiple sclerosis-like disease secondary to alpha interferon Reviewed

T Matsuo, R Takabatake

OCULAR IMMUNOLOGY AND INFLAMMATION 10 ( 4 ) 299 - 304 2002.12

Seropositivity of human herpesvirus-8 in patients with uveitis Reviewed

T Matsuo, M Itami

OCULAR IMMUNOLOGY AND INFLAMMATION 10 ( 3 ) 197 - 199 2002.9

Submacular exudates with serous retinal detachment caused by cat scratch disease Reviewed

T Matsuo, M Kato

OCULAR IMMUNOLOGY AND INFLAMMATION 10 ( 2 ) 147 - 150 2002.6

The incidence and pathology of conjunctival ulceration in Behcet's syndrome Reviewed

T Matsuo, M Itami, H Nakagawa, M Nagayama

BRITISH JOURNAL OF OPHTHALMOLOGY 86 ( 2 ) 140 - 143 2002.2

Two cases of ocular injury due to air-bag activation

F. Nonaka, M. Nagayama, T. Matsuo, F. Shiraga, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology 55 ( 2 ) 158 - 162 2001

A novel gene (retinovin) expressed selectively in the early stage of chick retinal development Reviewed

M Itami, T Matsuo, H Ohtsuki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276 ( 1 ) 12 - 15 2000.9

Identification of ingrowth site of idiopathic subfoveal choroidal neovascularization by indocyanine green angiography Reviewed

Fumio Shiraga, Chieko Shiragami, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Hiroshi Ohtsuki

Ophthalmology 107 ( 3 ) 600 - 607 2000.3

Risk for ocular attacks following phacoemulsification and intraocular lens implantation in patients of Behcet disease

M. Takahashi, T. Matsuo, A. Yamaoka, H. Kuwada, H. Ohtsuki, Y. Inoue, K. Egi

Japanese Journal of Clinical Ophthalmology 54 ( 8 ) 1499 - 1502 2000

Surgical treatment of submacular hemorrhage associated with idiopathic polypoidal choroidal vasculopathy Reviewed

Fumio Shiraga, Toshihiko Matsuo, Shiho Yokoe, Ippei Takasu, Toshio Okanouchi, Hiroshi Ohtsuki, Hans E. Grossniklaus

American Journal of Ophthalmology 128 ( 2 ) 147 - 154 1999.8

A novel gene (oculomedin) induced by mechanical stretching in human trabecular cells of the eye Reviewed

Yukiko Sato, Toshihiko Matsuo, Hiroshi Ohtsuki

Biochemical and Biophysical Research Communications 259 ( 2 ) 349 - 351 1999.6

Choroidal abnormalities in Behçet disease observed by simultaneous indocyanine green and fluorescein angiography with scanning laser ophthalmoscopy. Reviewed International journal

T Matsuo, Y Sato, F Shiraga, C Shiragami, Y Tsuchida

Ophthalmology 106 ( 2 ) 295 - 300 1999.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To examine choroidopathy in patients with Behçet disease. DESIGN: Prospective clinical study. PARTICIPANTS: Thirty-three patients (63 eyes) with Behçet disease. INTERVENTION: Patients underwent simultaneous indocyanine green (ICG) and fluorescein angiography with a double detector of scanning laser ophthalmoscopy. MAIN OUTCOME MEASURES: Angiographic findings recorded on videotapes were evaluated. The relation of angiographic findings with systemic activity and aqueous inflammation was also analyzed. RESULTS: Fluorescein angiography showed leakage in varying degrees from retinal vessels in 30 patients (53 eyes, 84%). The ICG angiographic findings were choroidal vascular wall staining in 16 eyes (25%), hyperfluorescent spots in 42 eyes (66%) and hypofluorescent plaques in 22 eyes (35%), both of which were not evident with fluorescein, leakage from choroidal vessels in 3 eyes (5%), and irregular filling of choriocapillaris in 11 eyes (17%). These findings did not have a statistically significant correlation with the presence or absence of aqueous inflammation or oral aphthous ulcerations. CONCLUSIONS: The patients with Behçet disease showed choroidal abnormalities, which could be revealed only by ICG angiography, but not with funduscopy or fluorescein angiography. Simultaneous ICG and fluorescein angiography would be useful for examining choroidal lesions in Behçet disease.

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Choroidal lesions in sarcoidosis evaluated by indocyanine green angiography

M. Itami, T. Matsuo, C. Shiragami, F. Shiraga, Y. Sato, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology 53 ( 4 ) 641 - 644 1999

Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits. International journal

C Shiragami, T Matsuo, F Shiraga, N Matsuo

The British journal of ophthalmology 82 ( 9 ) 1056 - 62 1998.9

Language：English Publishing type：Research paper (scientific journal)

AIMS: The authors studied how artificially damaged Bruch's membrane influenced growth and differentiation of transplanted embryonic retinal pigment epithelial (RPE) cells and of host RPE cells in rabbits. METHODS: Embryonic RPE cells obtained from pigmented rabbits were transplanted into the subretinal space of adult albino rabbits. The host RPE was removed with a silicone cannula, and Bruch's membrane was damaged by scratching with a microhooked 27 gauge needle under the detached retina in closed vitrectomy. The transplantation sites were examined 3, 7, and 14 days after surgery by light and electron microscopy. RESULTS: Varying degrees of damage in Bruch's membrane were observed. Pigmented and hypopigmented RPE cells showed a normal polarity and tight junctions were seen at the sites of mild to moderate damage 3-7 days after the surgery. In contrast, fibroblast-like cells with no such features of RPE cells formed multiple layers at the sites of severe damage involving the full thickness of Bruch's membrane and the choriocapillaris even 14 days after the surgery. Without transplantation, host RPE cells repopulated the damaged areas in the same way as transplanted RPE cells. CONCLUSIONS: Transplanted embryonic RPE cells as well as host RPE cells grew and differentiated on the moderately damaged Bruch's membrane, while the severely damaged Bruch's membrane did not allow differentiation of RPE cells although these cells could grow and cover the damaged areas.

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Bovine trabecular cells produce TIMP-1 and MMP-2 in response to mechanical stretching Reviewed

Y Okada, T Matsuo, H Ohtsuki

JAPANESE JOURNAL OF OPHTHALMOLOGY 42 ( 2 ) 90 - 94 1998.3

Aqueous vascular endothelial growth factor increases in anterior segment ischemia in rabbits Reviewed

T Tanaka, T Matsuo, H Ohtsuki

JAPANESE JOURNAL OF OPHTHALMOLOGY 42 ( 2 ) 85 - 89 1998.3

Geographic choroiditis and retinal vasculitis in rheumatoid arthritis Reviewed

Toshihiko Matsuo, Ikuya Masuda, Nobuhiko Matsuo

Japanese Journal of Ophthalmology 42 ( 1 ) 51 - 55 1998.1

Metastasis to the iris in squamous cell lung cancer Reviewed

Akio Hiraki, Hiroshi Ueoka, Toshihiko Matsuo, Tomio Nakagawa, Tadashi Yoshino, Katsuyuki Kiura, Masahiro Tabata, Katsuyoshi Sakae, Yuji Ohtsuki, Yoshio Hiraki, Mine Harada

International Journal of Clinical Oncology 3 ( 3 ) 186 - 190 1998

A case of atypical Treacher-Collins syndrome

Hirotake Fujiwara, Michio Sugihara, Toshihiko Matsuo, Miki Nouso, Satoshi Hasebe, Hiroshi Ohtsuki

Folia Ophthalmologica Japonica 48 ( 9 ) 1154 - 1157 1997.9

Bilateral iridocyclitis with retinal capillaritis in juveniles Reviewed

T. Matsuo, N. Matsuo

Ophthalmology 104 ( 6 ) 939 - 944 1997

Abducens nerve palsy in a case under treatment with systemic interferon

M. Hosogi, S. Hasebe, T. Matsuo, H. Ohtsuki

Japanese Journal of Clinical Ophthalmology 51 ( 7 ) 1357 - 1360 1997

Insufficiency of accommodation and convergence in whiplash injuries

Y. Tsutsui, T. Matsuo, K. Hasebe, H. Ohtsuki, N. Matsuo

Japanese Journal of Clinical Ophthalmology 49 ( 4 ) 775 - 778 1995

ANOMALOUS POSTERIOR INSERTION OF MEDIAL RECTUS MUSCLE SIMULATING CONGENITAL OCULOMOTOR PALSY Reviewed

M OKANO, T MATSUO, H KONISHI, S HASEBE, Y TADOKORO, H OHTSUKI

JAPANESE JOURNAL OF OPHTHALMOLOGY 34 ( 3 ) 275 - 279 1990

Familial hypo-retinol-binding proteinemia found in a child with keratomalacia Reviewed

T. Matsuo, N. Matsuo, F. Shiraga, N. Koide

Journal of Japanese Ophthalmological Society 92 ( 4 ) 694 - 698 1988

Mild type acute retinal necrosis syndrome involving both eyes at three-year interval Reviewed

T. Matsuo, T. Nakayama, T. Koyama, N. Matsuo

Japanese Journal of Ophthalmology 31 ( 3 ) 455 - 460 1987

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