Faculty Profiles - YAMAMOTO HIDETAKA

Papers - YAMAMOTO HIDETAKA

Division display 101 - 120 of about 320 ／ All the affair displays >>

Pan-tropomyosin receptor kinase immunoreactivity, ETV6-NTRK3 fusion subtypes, and RET rearrangement in salivary secretory carcinoma

Hidetaka Yamamoto, Yui Nozaki, Azusa Sugii, Kenichi Taguchi, Takahiro Hongo, Rina Jiromaru, Masanobu Sato, Takafumi Nakano, Kazuki Hashimoto, Minako Fujiwara, Yoshinao Oda

Human Pathology 109 37 - 44 2021.3

p16 overexpression and Rb loss correlate with high-risk HPV infection in oropharyngeal squamous cell carcinoma. International journal

Rina Jiromaru, Hidetaka Yamamoto, Ryuji Yasumatsu, Takahiro Hongo, Yui Nozaki, Takafumi Nakano, Kazuki Hashimoto, Takashi Nakagawa, Yoshinao Oda

Histopathology 79 ( 3 ) 358 - 369 2021.1

Language：English Publishing type：Research paper (scientific journal)

AIMS: p16 is a sensitive surrogate marker for transcriptionally active high-risk human papillomavirus (HR-HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC), but it is not sufficient in all clinical settings. METHODS AND RESULTS: We examined the p16 and Rb expression status in 177 OPSCC cases by immunohistochemistry and the presence of transcriptionally active HR-HPV infection by mRNA in-situ hybridisation. The 177 cases were divided into p16+ /HPV+ (n = 105, 59.3%), p16+ /HPV- (n = 8, 4.5%) and p16- /HPV- (n = 64, 36.2%) groups. The p16+ /HPV- and p16- /HPV- groups had a trend towards worse overall survival (OS) or significantly worse OS than the p16+ /HPV+ group (n = 105) (P = 0.0610, P = 0.0004, respectively). We divided the Rb status into preserved expression (> 90%, n = 68), partial loss (PL) (10-90%, n = 97) and complete loss (CL) (< 10%, n = 12). Among the HPV-positive cases (n = 105), the Rb pattern was typically PL (n = 97, 92.4%) and rarely CL (n = 8, 7.6%), but never preserved expression (0%). In contrast, among the HPV-negative cases (n = 72), the Rb pattern was typically preserved expression (n = 68, 94.4%) and rarely CL (n = 4, 5.6%), but never PL (0%). Compared to p16 alone, the combination of p16 overexpression and Rb-PL/CL showed equally excellent sensitivity (each 100%) and improved specificity (97.2 versus 88.9%) and positive predictive values (98.1 versus 92.9%). CONCLUSIONS: These results suggest that the combined use of p16 and Rb immunohistochemistry could be a reliable, cost-effective method to predict HR-HPV infection in OPSCCs; however, HPV specific testing is necessary on inconclusive cases. We propose a diagnostic algorithm for practical use of these markers.

DOI： 10.1111/his.14337

PubMed

researchmap

Clinicopathologic significance of EGFR mutation and HPV infection in sinonasal squamous cell carcinoma Reviewed International journal

Takahiro Hongo, Hidetaka Yamamoto, Rina Jiromaru, Yui Nozaki, Ryuji Yasumatsu, Kazuki Hashimoto, Reiko Yoneda, Azusa Sugii, Kenichi Taguchi, Muneyuki Masuda, Takashi Nakagawa, Yoshinao Oda

American Journal of Surgical Pathology 45 ( 1 ) 108 - 118 2021.1

PD-L1 and IDO-1 expression in undifferentiated pleomorphic sarcoma: The associations with tumor infiltrating lymphocytes, dMMR and HLA class I

Shin Ishihara, Yuichi Yamada, Takeshi Iwasaki, Masato Yoshimoto, Yu Toda, Kenichi Kohashi, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yasuharu Nakashima, Yoshinao Oda

Oncology Reports 45 ( 1 ) 379 - 389 2021.1

Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma. International journal

Ryutaro Uchi, Rina Jiromaru, Ryuji Yasumatsu, Hidetaka Yamamoto, Takahiro Hongo, Tomomi Manako, Kuniaki Sato, Kazuki Hashimoto, Takahiro Wakasaki, Mioko Matsuo, Takashi Nakagawa

Anticancer research 41 ( 1 ) 71 - 79 2021.1

Comprehensive molecular profiling broadens treatment options for breast cancer patients

Hitomi Kawaji, Makoto Kubo, Nami Yamashita, Hidetaka Yamamoto, Masaya Kai, Atsuko Kajihara, Mai Yamada, Kanako Kurata, Kazuhisa Kaneshiro, Yurina Harada, Saori Hayashi, Akiko Shimazaki, Hitomi Mori, Sayuri Akiyoshi, Eiji Oki, Yoshinao Oda, Eishi Baba, Masaki Mori, Masafumi Nakamura

Cancer Medicine 10 ( 2 ) 529 - 539 2021.1

Breast metastasis from pelvic high-grade serous adenocarcinoma: a report of two cases. International journal

Yurina Harada, Makoto Kubo, Masaya Kai, Mai Yamada, Karen Zaguirre, Tatsuhiro Ohgami, Hideaki Yahata, Yoshihiro Ohishi, Hidetaka Yamamoto, Yoshinao Oda, Masafumi Nakamura

Surgical case reports 6 ( 1 ) 317 - 317 2020.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Metastatic tumors to the breast reportedly account for 0.5% to 2.0% of all malignant breast diseases. Such metastatic tumors must be differentiated from primary breast cancer. Additionally, few reports have described metastases of gynecological cancers to the breast. We herein report two cases of metastasis of pelvic high-grade serous adenocarcinoma to the breast. CASE PRESENTATION: The first patient was a 57-year-old woman with a transverse colon obstruction. Colostomy was performed, but the cause of the obstruction was unknown. We found scattered white nodules disseminated throughout the abdominal cavity and intestinal surface. Follow-up contrast-enhanced computed tomography (CT) showed an enhanced nodule outside the right mammary gland. Core needle biopsy (CNB) of the right breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. We diagnosed the patient's condition as breast and lymph node metastasis of a high-grade serous carcinoma of the female genital tract. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. The second patient was a 71-year-old woman with a medical history of low anterior resection for rectal cancer at age 49, partial right thyroidectomy for follicular thyroid cancer at age 53, and left lower lung metastasis at age 57. Periodic follow-up CT showed peritoneal dissemination, cancerous peritonitis, and pericardial effusion, and the patient was considered to have a cancer of unknown primary origin. Contrast-enhanced CT showed an enhanced nodule in the left mammary gland with many enhanced nodules and peritoneal thickening in the abdominal cavity. CNB of the left breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. CONCLUSIONS: We experienced two rare cases of intramammary metastasis of high-grade serous carcinoma of female genital tract origin. CNB was useful for confirming the histological diagnosis of these cancers that had originated from other organs. A correct diagnosis of such breast tumors is important to ensure quick and appropriate treatment.

DOI： 10.1186/s40792-020-01090-7

PubMed

researchmap

Characterization of parotid gland tumors: added value of permeability MR imaging to DWI and DCE-MRI Reviewed International journal

Hidetake Yabuuchi, Takeshi Kamitani, Koji Sagiyama, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Takuya Hino, Yuriko Murayama, Ryuji Yasumatsu, Hidetaka Yamamoto

European Radiology 30 ( 12 ) 6402 - 6412 2020.12

Clinicopathological features and immunohistochemical utility of NTRK-, ALK-, and ROS1-rearranged papillary thyroid carcinomas and anaplastic thyroid carcinomas Reviewed International journal

Yui Nozaki, Hidetaka Yamamoto, Takeshi Iwasaki, Masanobu Sato, Rina Jiromaru, Takahiro Hongo, Ryuji Yasumatsu, Yoshinao Oda

Human Pathology 106 82 - 92 2020.12

Chronic inflammatory changes and oxidative stress in the background of “pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm” Reviewed International journal

Ryota Matsuda, Yoshihiro Miyasaka, Yuichi Yamada, Jun Kawata, Kukiko Sakihama, Takeo Yamamoto, Kiyoshi Saeki, Hidetaka Yamamoto, Yoshihiro Ohishi, Yutaka Koga, Masafumi Nakamura, Yoshinao Oda

Virchows Archiv 477 ( 6 ) 799 - 806 2020.12

Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors Reviewed

Yosuke Minoda, Eikichi Ihara, Keishi Komori, Haruei Ogino, Yoshihiro Otsuka, Takatoshi Chinen, Yasuo Tsuda, Koji Ando, Hidetaka Yamamoto, Yoshihiro Ogawa

Journal of Gastroenterology 55 ( 12 ) 1119 - 1126 2020.12

Prognostic impact of CRTC1/3-MAML2 fusions in salivary gland mucoepidermoid carcinoma: A multiinstitutional retrospective study Reviewed International journal

Yoshihide Okumura, Satsuki Nakano, Takayuki Murase, Kaori Ueda, Daisuke Kawakita, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Satoshi Kano, Kiyoaki Tsukahara, Kenji Okami, Toru Nagao, Nobuhiro Hanai, Hiroshi Iwai, Ryo Kawata, Yuichiro Tada, Ken Ichi Nibu, Hiroshi Inagaki

Cancer Science 111 ( 11 ) 4195 - 4204 2020.11

Frequent MN1 gene mutations in malignant peripheral nerve sheath tumor

Izumi Kinoshita, Yuichi Yamada, Kenichi Kohashi, Hidetaka Yamamoto, Takeshi Iwasaki, Shin Ishihara, Yu Toda, Yoshihiro Ito, Yousuke Susuki, Kengo Kawaguchi, Toshio Ichiki, Yuki Sato, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda

Anticancer Research 40 ( 11 ) 6221 - 6228 2020.11

B cell receptor signaling related to resistance to Helicobacter pylori eradication therapy in gastric diffuse large B cell lymphoma. Reviewed International journal

Takehiro Torisu, Shinichi Kawano, Kohta Miyawaki, Hidetaka Yamamoto, Yutaro Ihara, Yuichi Matsuno, Kumiko Torisu, Takeshi Sugio, Kensuke Sasaki, Takashi Shimakawa, Koji Kato, Koichi Akashi, Shotaro Nakamura, Takanari Kitazono

Hematological oncology 39 ( 1 ) 145 - 147 2020.10

PD-L1 and IDO1 expression and tumor-infiltrating lymphocytes in osteosarcoma patients: comparative study of primary and metastatic lesions Reviewed International journal

Yu Toda, Kenichi Kohashi, Yuichi Yamada, Masato Yoshimoto, Shin Ishihara, Yoshihiro Ito, Takeshi Iwasaki, Hidetaka Yamamoto, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda

Journal of Cancer Research and Clinical Oncology 146 ( 10 ) 2607 - 2620 2020.10

The impact of clinicopathological factors on clinical outcomes in patients with salivary gland adenoid cystic carcinoma: a multi-institutional analysis in Japan. Reviewed

Daisuke Kawakita, Takayuki Murase, Kaori Ueda, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Takuma Matoba, Kazuo Sakurai, Toru Nagao, Nobuhiro Hanai, Ryo Kawata, Naohito Hato, Ken-Ichi Nibu, Makoto Urano, Ken-Ichi Taguchi, Masato Nakaguro, Kimihide Kusafuka, Hidetaka Yamamoto, Toshitaka Nagao, Hiroshi Inagaki

International journal of clinical oncology 25 ( 10 ) 1774 - 1785 2020.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Owing to the low incidence of adenoid cystic carcinoma (AdCC), reliable survival estimates and prognostic factors remained unclarified. METHODS: In this multi-institutional retrospective analysis, we collected 192 AdCC cases, and investigated the impact of clinicopathological factors on clinical outcomes of the patients. All AdCC cases were of salivary gland origin and were surgically treated with curative intent. Diagnoses of AdCC were validated by a central pathology review by expert pathologists. RESULTS: The 5-year overall survival (OS) and disease-free survival (DFS) rates were 92.5 and 50.0%, respectively. Treatment failure occurred in 89 patients (46%) with the distant failures in 65 (34%). Multivariate analysis indicated that pN2 and a pathologically positive surgical margin were independent prognostic factors for both OS and DFS. Histological grade III was an independent prognostic factor for OS. A primary site in the submandibular gland, pT3/4, pN1, and histological grade II were independent prognostic factors for DFS. Postoperative radiation therapy (PORT) improved the locoregional control (LRC) rate. Prophylactic neck dissection was not associated with a better OS or better LRC among patients with cN0. Facial nerve dissection did not improve clinical outcomes in parotid AdCC cases without facial nerve palsy. CONCLUSIONS: A higher TN classification, a pathologically positive surgical margin, and a higher histological grade were associated with a lower OS. PORT improved LRC rates but neck dissection failed to improve clinical outcomes in patients with cN0. As the distant metastasis was frequent, effective systemic therapy is imperative to improve the survival of AdCC patients.

DOI： 10.1007/s10147-020-01731-9

PubMed

researchmap

Benign mesenteric lipomatous tumor in a child: a case report and literature review. Reviewed International journal

Naoki Hashizume, Takato Aiko, Suguru Fukahori, Shinji Ishii, Nobuyuki Saikusa, Yoshinori Koga, Naruki Higashidate, Saki Sakamoto, Shiori Tsuruhisa, Hirotomo Nakahara, Hiroko Muta, Hiroaki Miyoshi, Yoshiki Naito, Hidetaka Yamamoto, Yoshinao Oda, Yoshiaki Tanaka, Minoru Yagi

Surgical case reports 6 ( 1 ) 243 - 243 2020.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Lipomatous tumors are the most common type of soft-tissue tumors. Benign lipomatous tumors are lipomas and lipoblastoma. We herein report a case of benign mesenteric lipomatous tumor and the largest collection of known benign mesenteric lipomatous tumors in children in the literature. CASE PRESENTATION: A 3-year-old girl presented with repeated dull abdominal pain and left abdominal mass swelling. On a physical examination, the child had a soft, moderately distended left abdomen that was not tender when palpated. Computed tomography and magnetic resonance imaging demonstrated a large fatty mass within the mesentery, measuring approximately 8 × 6 cm. The mass extended from the right upper quadrant to the lower pole of the kidneys. Laparotomy with resection of the mesenteric tumor was performed under general anesthesia. A well-capsuled tumor was a soft, yellow mass and found loosely attached to the mesenterium of the ileum. A histopathological examination demonstrated the lobular proliferation of mature adipocytes. Atypical lipoblasts were not seen. These features are compatible with benign lipomatous tumor, such as lipoma or lipoblastoma with maturation. CONCLUSION: In conclusion, benign mesenteric lipomatous tumors tend to be large in size over 10 cm in longitudinal length. However, resection is well tolerated in the vast majority of cases with benign post-operative courses.

DOI： 10.1186/s40792-020-01020-7

PubMed

researchmap

Plasmablastic lymphoma occurring in the vicinity of enterocutaneous fistula in Crohn's disease. Reviewed International journal

Seisho Sato, Makiko Nakahara, Koji Kato, Tomohiko Moriyama, Sae Utsumi, Kensuke Sasaki, Takahiro Shima, Hiroaki Miyoshi, Hidetaka Yamamoto, Masutaka Furue

The Journal of dermatology 47 ( 12 ) e442-e443 2020.9

Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors. Reviewed International journal

Takeshi Kamitani, Koji Sagiyama, Osamu Togao, Yuzo Yamasaki, Tomoyuki Hida, Yuko Matsuura, Yuriko Murayama, Ryuji Yasumatsu, Hidetaka Yamamoto, Hidetake Yabuuchi

European journal of radiology 129 109047 - 109047 2020.8

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To assess the usefulness of amide proton transfer (APT) imaging in differentiating parotid tumors. MATERIAL AND METHODS: We retrospectively analyzed 43 histopathologically proven parotid solid tumors with diameters ≥2 cm. Twenty-one tumors were benign and 12 tumors were malignant. Two-dimensional APT imaging was performed using a saturation pulse with a duration of 2 s and a saturation power level of 2 μT. For acquiring Z-spectra, the imaging was repeated at 25 saturation frequency offsets from ω = -6 to +6 ppm with a step of 0.5 ppm as well as one scan acquired far off-resonance (-1560 ppm) for signal normalization. For the APT imaging, the asymmetry analysis at 3.5 ppm downfield from the water signal was calculated. The mean APT signal intensity (SI) was compared between the benign and malignant tumors. RESULTS: The mean APT SI was 2.23 ± 0.80 % in the benign tumors and significantly higher at 2.99 ± 0.99 % in the malignant tumors (P = 0.01). A receiver operating curve analysis revealed that the optimal APT SI threshold was 2.40 for distinguishing malignant tumors from benign tumors with an area under the curve of 0.74. The sensitivity, specificity, and accuracy were 83.3%, 61.3%, and 67.4%, respectively. CONCLUSION: The mean APT SI of the malignant parotid tumors was significantly higher than that of the benign parotid tumors.

DOI： 10.1016/j.ejrad.2020.109047

PubMed

researchmap

Central pathology review of salivary gland adenoid cystic carcinoma. Reviewed International journal

Kaori Ueda, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Makoto Urano, Hidetaka Yamamoto, Masato Nakaguro, Ken-Ichi Taguchi, Ayako Masaki, Hideaki Hirai, Daisuke Kawakita, Kiyoaki Tsukahara, Naohito Hato, Toru Nagao, Yasushi Fujimoto, Kazuo Sakurai, Nobuhiro Hanai, Satoshi Kano, Tetsuro Onitsuka, Kenji Okami, Ken-Ichi Nibu, Yuichiro Tada, Ryo Kawata, Hiroshi Inagaki

Head & neck 42 ( 8 ) 1721 - 1727 2020.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: To assess the role of a central pathology review in the diagnosis of salivary gland adenoid cystic carcinoma (AdCC). METHODS: Surgically resected salivary gland tumors diagnosed as AdCC (n = 219) in 15 reference hospitals in Japan were subjected to a retrospective pathological re-evaluation. RESULTS: After the review, the AdCC diagnosis was revised in 21/219 cases (9.6%). The six benign tumors (2.7%) comprised five basal cell adenomas and one pleomorphic adenoma, and among these six patients, three received postoperative radiotherapy. The remaining 15 malignant tumors (6.8%) comprised nine basal cell adenocarcinomas and six other carcinomas. All revised basal cell adenoma/adenocarcinoma cases were of rare cribriform variants. CONCLUSIONS: A significant proportion of AdCC pathology reports were revised after the central pathology review. It should be emphasized that the greatest attention should be paid in differentiating AdCC from cribriform variant basal cell adenoma/adenocarcinoma, which is very rare in salivary gland tumors.

DOI： 10.1002/hed.26081

PubMed

researchmap

　 PREV - NEXT 　

< YAMAMOTO HIDETAKA >

Papers - YAMAMOTO HIDETAKA