2021/04/08 更新

写真a

アシダ コウゾウ
芦田 耕三
ASHIDA Kozo
所属
医歯薬学域 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 肝臓病学

研究分野

  • ライフサイエンス / 呼吸器内科学

  • ライフサイエンス / 内科学一般

  • ライフサイエンス / 消化器内科学

学歴

  • 岡山大学   Faculty of Medicine  

    - 1987年

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  • 岡山大学   医学部   医学

    - 1987年

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    国名: 日本国

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経歴

  • - 岡山大学医歯薬学総合研究科 教授

    2016年

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  • 岡山大学岡山大学病院 准教授   Okayama University Hospital

    2015年

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  • 岡山大学岡山大学病院 講師   Okayama University Hospital

    2004年 - 2015年

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  • 米国国立衛生研究所 客員研究員

    1997年 - 1999年

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  • みのり会北川病院 医員

    1990年 - 1991年

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  • 岡山済生会総合病院 医員

    1987年 - 1990年

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▼全件表示

所属学協会

委員歴

  • 日本内科学会   中国地方会評議員  

    1997年   

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    団体区分:学協会

    日本内科学会

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書籍等出版物

  • 研究方法(6)Im situ ハイブリダイゼ-ション(共著)

    細胞外マトリックス(渡辺、岡崎編) 

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MISC

  • Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains

    Masaharu Takahashi, Tsutomu Nishizawa, Shigeo Nagashima, Suljid Jirintai, Manri Kawakami, Yoshihide Sonoda, Tadahiro Suzuki, Shogo Yamamoto, Kazuhiro Shigemoto, Kozo Ashida, Yukihiro Sato, Hiroaki Okamoto

    VIRUS RESEARCH   180 ( 2 )   59 - 69   2014年2月

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    記述言語:英語   出版者・発行元:ELSEVIER SCIENCE BV  

    Although a consensus classification system for hepatitis E virus (HEV) genotypes is currently unavailable, HEV variants (JBOAR135-Shiz09 and wbJOY_06) from wild boars (Sus scrofa leucomystax) have provisionally been classified into two novel genotypes (5 and 6). While performing a survey of HEV infections among 566 wild boars that were captured in Japan between January 2010 and August 2013, we found 24 boars (4.2%) with ongoing HEV infections: 13 had genotype 3 HEV, 10 had genotype 4 HEV and the remaining boar possessed a novel HEV variant (designated wbJNN_13). The entire wbJNN_13 genome comprised 7247 nucleotides excluding the poly(A) tail, and was highly divergent from known genotype 1 to 4 HEV isolates derived from humans, swine, wild boars, deer, mongoose and rabbits by 22.4-28.2%, JBOAR135-Shiz09 and wbJOY_06 by 19.6-21.9% and rat, ferret, bat and avian HEV isolates by 40.9-46.1% over the entire genome. Phylogenetic trees confirmed that wbJNN_13 is distantly related to all known HEV isolates. A Simplot analysis revealed no significant recombination among the existing HEV strains. These results indicate the presence of at least three genetic lineages of presumably boar-indigenous HEV strains. Further studies to fully understand the extent of the genomic heterogeneity of HEV variants infecting wild boars are warranted. (C) 2013 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.virusres.2013.12.014

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  • EFFECT of repeated Waon therapy on exercise tolerance and pulmonary function in patients with chronic obstructive pulmonary disease a pilot controlled clinical trial

    Int J Chron Obstruct Pulmon Dis.   9 ( 1 )   9 - 15   2013年

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  • Effect of spa Therapy on the six-minute Walk Test in patients with chronic obstructive pulmonary disease

    Shingo Takata, Kozo Ashida, Yasuhiro Hosaki, Masanori Hamada, Naofumi Iwagaki, Hiroshi Kikuchi, Fumihiro Mitsunobu

    日本温泉気候物理医学会雑誌   71 ( 4 )   241 - 249   2008年

  • Effect of Spa Therapy on the Six-minute Walk Test in Patients with Chronic Obstructive Pulmonary Disease

    Takata S, Ashida K, Hosaki Y, Iwagaki N, Kikuchi H, Mitsunobu F

    The Journal of the Japanese Society of Balneology, Climatology and Physical Medicine   71 ( 4 )   239 - 241   2008年

  • 肝細胞癌の経過中に肝原発腺扁平上皮癌を合併した1例

    高田真吾, 芦田耕三, 保﨑泰弘, 濱田全紀, 岩垣尚史, 菊池宏, 光延文裕

    岡大三朝医療センター研究報告   76   41 - 48   2008年

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  • 帯状疱疹後神経痛に対する温泉を利用したリハビリテーションの経験

    濱田全紀, 光延文裕, 保﨑泰弘, 芦田耕三, 岩垣尚史, 高田真吾, 菊池宏

    岡大三朝医療センター研究報告   76   31 - 34   2008年

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  • ケトプロフェン湿布剤により全身性麻疹様紅斑を来した1例

    高田真吾, 芦田耕三, 保﨑泰弘, 濱田全紀, 岩垣尚史, 菊池宏, 光延文裕

    岡大三朝医療センター研究報告   76   35 - 40   2008年

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  • Effect of spa Therapy on the six-minute Walk Test in patients with chronic obstructive pulmonary disease

    Shingo Takata, Kozo Ashida, Yasuhiro Hosaki, Masanori Hamada, Naofumi Iwagaki, Hiroshi Kikuchi, Fumihiro Mitsunobu

    岡大三朝医療センター研究報告   76   24 - 30   2008年

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  • 2002-2007年における当院市中肺炎入院症例の臨床的研究

    高田真吾, 保﨑泰弘, 芦田耕三, 濱田全紀, 岩垣尚史, 菊池宏, 光延文裕

    岡大三朝医療センター研究報告   76   12 - 17   2008年

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  • 慢性閉塞性肺疾患患者の運動耐容能・肺機能に対する温熱療法の有効性についての検討ーpilot study-

    菊池宏, 保﨑泰弘, 芦田耕三, 濱田全紀, 岩垣尚史, 高田真吾, 光延文裕

    岡大三朝医療センター研究報告   76   18 - 23   2008年

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  • A case with persistent asthma symptoms despite fluticasone treatment in which concomitant treatment with montelukast and perilla seed oil-rich supplementation significantly improved asthma control

    Shingo Takata, Kozo Ashida, Yasuhiro Hosaki, Masanori Hamada, Naofumi Iwagaki, Hiroshi Kikuchi, Fumihiro Mitsunobu

    岡大三朝医療センター研究報告   76   53 - 59   2008年

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  • 呼吸器疾患の温泉療法ー25年間の入院症例2762例を対象にー

    光延文裕, 保﨑泰弘, 芦田耕三, 岩垣尚史, 高田真吾, 菊池宏, 濱田全紀

    岡大三朝医療センター研究報告   76   1 - 11   2008年

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  • Effect of foot baths containing artificial CO2 on peripheral circulation.

    Hosaki Y, Ashida K, Hamada M, Fujii M, Iwagaki N, Takata S, Tabuki K, Mitsunobu F

    J Jpn Assoc Phys Med Balneol Climatol   2006年

  • The effects of spa therapy combined with dietary supplementation with n-3 fatty acids on serum eosinophil cationic protein in asthmatic subject.

    Takata S, Ashida K, Hosaki Y, Hamada M, Iwagaki N, Fujii M, Mitsunobu F

    J Jpn Assoc Phys Med Balneol Climatol   2006年

  • 温泉療法による気管支喘息治療薬剤費の削減効果

    芦田 耕三, 光延 文裕, 保崎 泰弘, 濱田 全紀, 岩垣 尚史, 藤井 誠, 高田 真吾, 谷崎 勝朗

    日本温泉気候物理医学会雑誌   68 ( 3 )   166 - 174   2005年

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    記述言語:英語   出版者・発行元:一般社団法人 日本温泉気候物理医学会  

    気管支喘息23例を対象に、温泉療法を開始した1年間 (1997年) と開始3年後 (2000年) の1年間の薬剤費を比較することによって、長期温泉療法による薬剤費の削減の可能性について検討を加えた。なお、気管支喘息の重症度は国際分類に準じ、ステージ1から4までの4段階で行った。1. 温泉療法による総薬剤費の1年間の平均削減は、ステージ1では\31,910、ステージ2では\74,900、3では\113,450、4では\180,910であった。これを削減率で表すと、それぞれステージ1では34.2%、2では46.3%、3では37.1%、4では42.4%であり、温泉療法による薬剤費の削減は、金額では喘息の重症度が高くなるにつれて多くなること、また、削減率ではステージ2と4で40%以上の高い削減率が示された。2. 温泉療法による薬剤の種類別の薬剤費の削減では、気管支拡張薬、副腎皮質ホルモン、抗アレルギー薬、粘液溶解薬、抗生物質などの薬剤費は、いずれもステージ3および4の症例では有意の減少を示した。しかし、これらの薬剤費の減少はステージ1および2では、推計学的には有意の差ではなかった。3. これらの薬剤の削減率は、推計学的に有意差の見られるステージ3では、粘液溶解薬と抗生物質、またステージ4では気管支拡張薬、抗アレルギー薬、粘液溶解薬、抗生物質で50%以上の削減率が観察された。以上の結果より、気管支喘息のうち重症度の高い症例では、温泉療法により薬剤費の削減が可能であることが示唆された。

    DOI: 10.11390/onki1962.68.166

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  • Improvement of hyperinflation of the lungs by spa therapy in patients with asthma

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Hamada M, Tanizaki Y

    J Jpn Assoc Phys Med Balneol Climatol   2004年

  • Costs of drugs used for the treatmemt of asthma in relation to disease severity

    Tanizaki Y, Mitsunobu F, Hosaki Y, Ashida K, Hamada, M, Iwagaki N, Fujii M, Takata S

    Ann Rep Misasa Med Center Okayama Univ   2004年

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  • Comparison of pathophysiological changes of asthma between younger and older patients with asthma in relation to long-term cigarette smoking

    Mitsunobu F, Hosaki Y, Ashida K, Hamada M, Iwagaki N, Fujii M, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004年

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  • Cigarette smoking and pathophysiology of asthma and pulmonary emphysema.

    Ashida K, Mitsunobu F, Hosaki Y, Hamada M, Iwagaki N, Fujii M, Takata S, Tanizaki Y

    Ann Rep Misasa Med. Center Okayama Univ   75,74-87   2004年

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  • Enhanced leukotriene generation and bronchial hyperresponsiveness in asthmatics with allergic rhinitis

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Fujii M, Takata S, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004年

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  • Effects of spa therapy on reduction of the costs of the drugs used for the treatment of asthma in the elderly in relation to disease severity

    Ashida K, Mitsunobu F, Hosaki Y, Hamada M, Iwagaki N, Fujii M, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004年

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  • Five-year observation of the effects of spa therapy for patients with pulmonary emphysema, evaluated by %low attenuation area (%LAA) of the lungs on high resolution CT, %DLco, and % residual volume (RV).

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Nagata T, Fujii M, Takata S, Hamada M, Tanizaki Y

    J Jpn Assoc Phys Med Balneol Climatol   2004年

  • Spa therapy and bronchial hyperresponsiveness associated with cigarette smoking in asthmatics in the elderly

    Mitsunobu F, Hosaki Y, Ashida K, Iwagaki N, Fujii M, Takata S, Hamada M, Tanizaki Y

    Ann Rep Misasa Med Center Okayama Univ   2004年

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  • Decreased computed tomographic lung density during exacerbation of asthma

    F Mitsunobu, K Ashida, Y Hosaki, H Tsugeno, M Okamoto, N Nishida, T Nagata, S Takata, Y Tanizaki

    EUROPEAN RESPIRATORY JOURNAL   22 ( 1 )   106 - 112   2003年7月

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    記述言語:英語   出版者・発行元:EUROPEAN RESPIRATORY SOC JOURNALS LTD  

    Recently, it was shown that both mean lung density (MLD) and the relative lung area with an attenuation of <-950 HU (RA950) are related to severity of asthma in nonsmoking asthmatics. The aim of the present study was to examine whether reduced computed tomography (CT) lung density during exacerbation could change after treatment.
    A cross-sectional study was performed to compare CT lung density in 30 stable asthmatics, 30 unstable asthmatics and 25 control subjects. In order to investigate longitudinally the effect of treatment on decreased CT lung density, 17 asthmatics with an exacerbation were followed at the initiation of treatment and months after relief.
    The MLD was significantly lower and the RA950 significantly higher in unstable asthmatics than in controls and stable asthmatics. Both MLD and RA950 changed significantly with administration of systemic glucocorticoid therapy. The changes in forced expiratory volume in one second correlated significantly with those in both MLD and RA950. The changes in residual volume also correlated significantly with those in both MLD and RA950.
    It was concluded that decreased computed tomographic lung density during an asthma exacerbation is at least partially reversible, and changes in mean lung density and the relative lung area with a radiation attenuation of <-950 HU are related to the change in forced expiratory volume in one second and residual volume.

    DOI: 10.1183/09031936.03.00081702

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  • Decreased computed tomographic lung density during exacerbation of asthma

    F Mitsunobu, K Ashida, Y Hosaki, H Tsugeno, M Okamoto, N Nishida, T Nagata, S Takata, Y Tanizaki

    EUROPEAN RESPIRATORY JOURNAL   22 ( 1 )   106 - 112   2003年7月

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    記述言語:英語   出版者・発行元:EUROPEAN RESPIRATORY SOC JOURNALS LTD  

    Recently, it was shown that both mean lung density (MLD) and the relative lung area with an attenuation of <-950 HU (RA950) are related to severity of asthma in nonsmoking asthmatics. The aim of the present study was to examine whether reduced computed tomography (CT) lung density during exacerbation could change after treatment.
    A cross-sectional study was performed to compare CT lung density in 30 stable asthmatics, 30 unstable asthmatics and 25 control subjects. In order to investigate longitudinally the effect of treatment on decreased CT lung density, 17 asthmatics with an exacerbation were followed at the initiation of treatment and months after relief.
    The MLD was significantly lower and the RA950 significantly higher in unstable asthmatics than in controls and stable asthmatics. Both MLD and RA950 changed significantly with administration of systemic glucocorticoid therapy. The changes in forced expiratory volume in one second correlated significantly with those in both MLD and RA950. The changes in residual volume also correlated significantly with those in both MLD and RA950.
    It was concluded that decreased computed tomographic lung density during an asthma exacerbation is at least partially reversible, and changes in mean lung density and the relative lung area with a radiation attenuation of <-950 HU are related to the change in forced expiratory volume in one second and residual volume.

    DOI: 10.1183/09031936.03.00081702

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  • Complexity of terminal airspace geometry assessed by computed tomography in asthma

    F Mitsunobu, K Ashida, Y Hosaki, H Tsugeno, M Okamoto, K Nishida, S Takata, T Yokoi, M Mishima, Y Tanizaki

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   167 ( 3 )   411 - 417   2003年2月

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    記述言語:英語   出版者・発行元:AMER THORACIC SOC  

    Low attenuation areas in computed tomography images from patients with chronic obstructive pulmonary disease have been reported to represent macroscopic and/or microscopic emphysema. The cumulative size distribution of the clusters has been shown to follow a power law characterized by the exponent D, a measure of the complexity of the terminal airspace geometry. We have previously found increased low attenuation areas in nonsmoking subjects with asthma. We examined the size distribution of the clusters in nonsmoking subjects with asthma compared with both nonsmoking control subjects and subjects with asthma with a smoking history. The percentage of lung field occupied by low attenuation areas (LAA%) and D in subjects with asthma with a smoking history differed significantly from nonsmoking subjects with asthma and control subjects. In nonsmoking subjects with asthma, both parameters differed significantly between severe asthma and mild or moderate asthma. The LAA% differed significantly between moderate and mild asthma, but D did not. In mild and moderate asthma, a highly significant correlation between LAA% and D was observed in patients with a smoking history, but not in nonsmoking subjects with asthma. Our results suggest that decreased D is mostly related to emphysematous change, and both measurements of LAA% and D may provide useful information to characterize low attenuation areas in subjects with asthma.

    DOI: 10.1164/rccm.2112070

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  • Complexity of terminal airspace geometry assessed by computed tomography in asthma

    F Mitsunobu, K Ashida, Y Hosaki, H Tsugeno, M Okamoto, K Nishida, S Takata, T Yokoi, M Mishima, Y Tanizaki

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   167 ( 3 )   411 - 417   2003年2月

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    記述言語:英語   出版者・発行元:AMER THORACIC SOC  

    Low attenuation areas in computed tomography images from patients with chronic obstructive pulmonary disease have been reported to represent macroscopic and/or microscopic emphysema. The cumulative size distribution of the clusters has been shown to follow a power law characterized by the exponent D, a measure of the complexity of the terminal airspace geometry. We have previously found increased low attenuation areas in nonsmoking subjects with asthma. We examined the size distribution of the clusters in nonsmoking subjects with asthma compared with both nonsmoking control subjects and subjects with asthma with a smoking history. The percentage of lung field occupied by low attenuation areas (LAA%) and D in subjects with asthma with a smoking history differed significantly from nonsmoking subjects with asthma and control subjects. In nonsmoking subjects with asthma, both parameters differed significantly between severe asthma and mild or moderate asthma. The LAA% differed significantly between moderate and mild asthma, but D did not. In mild and moderate asthma, a highly significant correlation between LAA% and D was observed in patients with a smoking history, but not in nonsmoking subjects with asthma. Our results suggest that decreased D is mostly related to emphysematous change, and both measurements of LAA% and D may provide useful information to characterize low attenuation areas in subjects with asthma.

    DOI: 10.1164/rccm.2112070

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  • 高齢者の内科診療 アレルギー・膠原病 高齢者気管支喘息の病態と治療

    谷崎勝朗, 光延文裕, 保崎泰弘, 芦田耕三

    日本内科学会雑誌   92(3),448-452   2003年

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  • 高齢者気管支喘息の病態に及ぼす加齢及び喫煙の影響について(2)

    谷崎勝朗, 光延文裕, 保崎泰弘, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 永田拓也, 高田真吾, 横井正

    岡大三朝医療センター研究報告   73,93-101   2003年

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  • Long-term Spa Therapy Prevents the Progressive Pathological Changes of the lung in Patients with Pulmonary Emphysema.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi Y, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003年

  • Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma.

    Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki

    J Radiat Res   2003年

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  • Elevation of antioxidant enzymes in the clinical effects of radon and thermal therapy for bronchial asthma.

    Mitsunobu F, Yamaoka K, Hanamoto K, Kojima S, Hosaki Y, Ashida K, Sugita K, Tanizaki Y

    J Radiat Res   2003年

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  • Spa Therapy for Patients with Respiratory Disease Admitted at Misasa Medical Center for Last 20 Years.

    Mitusnobu F, Hosaki Y, Ashida K, Nishida N, Tsugeno H, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003年

  • A proton-pump inhibitor, rabeprazole, improves ventilatory function in patients with asthma associated with gastroesophageal reflux

    H Tsugeno, M Mizuno, S Fujiki, H Okada, M Okamoto, Y Hosaki, S Ashida, F Mitsunobu, Y Tanizaki, Y Shiratori

    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY   38 ( 5 )   456 - 461   2003年

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    記述言語:英語   出版者・発行元:TAYLOR & FRANCIS AS  

    Background: Treatment of gastroesophageal reflux (GER) with proton-pump inhibitors (PPI) improves symptoms of asthma in some patients. However, the effects of a PPI on ventilatory function are still controversial. In this study, we measured ventilatory function in asthma patients treated with a PPI in order to identify those in whom a therapeutic effect on asthma can be expected from the acid suppression. Methods: From a cohort of 114 consecutive patients with bronchial asthma, 53 patients agreed to participate in the study and were treated with rabeprazole 20 mg daily for 8 weeks during an asymptomatic, stable period with no exacerbations of their asthma. Of the 53 patients, 22 were diagnosed as GER on the basis of the QUEST questionnaire and endoscopic examination. The patients were monitored for improvement in ventilatory function. Results: Four patients dropped out because of adverse drug reactions. All the patients with GER noted an improvement in reflux symptoms with PPI treatment. An improvement of more than 20% in peak expiratory flow (PEF) was observed in 8 of 21 GER patients but in none of the non-GER patients. Factors predictive of improvement in PEF with rabeprazole therapy were the QUEST score (odds ratio: 1.47, 95% CI: 1.06-2.04, P = 0.022) and steroid-dependency of asthma (odds ratio: 0.01, 95% CI: 0.001-0.31, P = 0.008). Conclusions: Treatment with rabeprazole is expected to ameliorate asthma in non-steroid-dependent patients who have symptomatic GER defined by the QUEST score.

    DOI: 10.1080/00365520310002490

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  • Effects of spa therapy combined with dietary supplementation with α-linolenic acids on bronchial asthma.

    Okamoto M, Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y, Tanimoto M

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • Infiuence of long-term cigarette smoking on changes of lung density by high-resolution computed tomography in asthmatics-4 years follow-up study-.

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi Y, Nakai M, Tanizaki Y, Tanimoto M

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • Assessment of etidronic acid plus alfacalcidol for the treatment of osteopenia in steroid-dependent asthmatics. A pilot study of five cases.

    Tsugeno H, Nakai M, Okamoto M, Yokoi T, Takata S, Niashida N, Ashida K, Mitsunobu F, Yuki H, Tanizaki Y, Shiratori Y

    Clin Drug Invest   2003年

  • Bromocriptineにより白血球減少症及び血小板減少症をきたしたパーキンソン病の1例

    高田真吾, 御舩尚志, 光延文裕, 岡本誠, 西田典数, 柘野浩史, 芦田耕三, 保崎泰弘, 横井正, 谷崎勝朗, 新谷憲治, 谷本光音

    岡大三朝医療センター研究報告   2003年

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  • 早期診断にて軽快したMPO-ANCA関連血管炎の一例

    市川裕久, 芦田耕三, 小野勝一郎, 高田真吾, 横井正, 永田拓也, 岡本誠, 柘野浩史, 西田典数, 保崎泰弘, 光延文裕, 谷崎勝朗, 野口善範, 谷本光音

    岡大三朝医療センター研究報告   2003年

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  • Effects of Spa Therapy Combined with Dietary Supplementation with n-3 Fatty Acids on Bronchial Asthma.

    Okamoto M, Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003年

  • Decrease in Low Attenuation Area (LAA) of the Lungs on High Resolution Computed Tomography (HRCT) by Long-term Spa Therapy in Patients with Asthma.

    Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Yokoi Y, Tanizaki Y

    J.Jpn Assoc Phys Med Balm Clim   2003年

  • 温泉療法が骨関節症患者のQOLに及ぼす効果

    横井正, 千田益生, 光延文裕, 保崎泰弘, 芦田耕三, 西田典数, 柘野浩史, 永田拓也, 高田真吾, 谷崎勝朗, 井上一

    岡大三朝医療センター研究報告   2003年

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  • Yawning associated with anterior chest pain in a patient with asthma

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Nagata T, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • レーザードプラー血流計による高齢者の末梢循環の数量的解析

    保崎泰弘, 光延文裕, 芦田耕三, 柘野浩史, 西田典数, 永田拓也, 高田真吾, 横井正, 谷崎勝朗, 越智浩二, 福田哲也, 白鳥康史

    岡大三朝医療センター研究報告   2003年

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  • BNPの著明な高値が持続した高齢者陳旧性心筋梗塞患者(高齢者のBNPについての考察も加えて)

    西田典数, 芦田耕三, 光延文裕, 保崎泰弘, 柘野浩史, 岡本誠, 永田拓也, 高田真吾, 横井正, 中井睦郎, 槙野博史, 谷崎勝朗

    岡大三朝医療センター研究報告   2003年

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  • An increase in bronchial hyperresponsiveness by cigarette smoking in elderly patients with asthma.

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • Effect of aging on the pathophysiology of asthma observed by IgE-mediated allergy, pulmonary function,low attenuation area of the lungs on HRCT, and LTB4,LTC4 generation.

    Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • Long-term cigarette smoking influences low attenuation area of the lungs on high-resolution CT in elderly patients with asthma, compared with pulmonary emphysema.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Nishida N, Nagata T, Takata S, Yokoi Y, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • 呼吸器疾患の温泉療法-21年間の入院症例2129例を対象に-

    谷崎勝朗, 光延文裕, 保﨑泰弘, 芦田耕三, 西田典数, 柘野浩史, 永田拓也, 横井正, 高田真吾

    岡大三朝医療センター研究報告   2003年

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  • Airflow, the volume and transfer factor of lungs in elderly asthmatics with ling-term cigarette smoking.

    Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Nishida N, Nagata T, Yokoi Y, Takata S, Tanizaki Y

    Ann Rep Misasa Med Center, Okayama univ Med Sch   2003年

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  • Effects of α-linolenic acid-rich supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism

    Okamoto M, Mitusnobu F, Ashida K, Hosaki Y, Tsugeno H, Nishida N, Yokoi T, Takata S, Tanizaki Y, Tanimoto M

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002年

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  • 呼吸器疾患に対する温泉療法―最近20年間の入院症例1934例を対象にー

    谷崎勝朗, 光延文裕, 保﨑泰弘, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 高田真吾, 横井正

    岡大三朝分院研究報告   2002年

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  • Non-invasive study for peripheral circulation in patients with diabetes mellitus

    Hosaki Y, Mitusnobu F, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Tanizaki Y, Ochi K, Tsuji T

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002年

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  • The generation of leukotrienes B4(LTB4) and C4(LTC4) and bronchial hyperresponsiveness in patients with asthma and spa therapy

    Ashida K, Mitusnobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002年

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  • 腰痛症患者における腰椎MRI画像所見の検討

    高田真吾, 横井正, 西田典数, 岡本誠, 柘野浩史, 芦田耕三, 保﨑泰弘, 御舩尚志, 光延文裕, 谷崎勝朗, 新谷憲治, 谷本光音

    岡大三朝分院研究報告   2002年

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  • RA患者のQOL -SF-36を用いて-

    横井正, 千田益生, 光延文裕, 保崎泰弘, 芦田耕三, 西田典数, 柘野浩史, 岡本誠, 高田真吾, 谷崎勝朗, 井上 一

    岡大三朝分院研究報告   2002年

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  • 解離性大動脈瘤と冠動脈狭窄病変のマルチスライス(多列検出器型高速)CT画像診断(解離性上行大動脈瘤と狭心症を合併した一患者の診断と考察を元に)

    西田典数, 芦田耕三, 光延文裕, 保﨑泰弘, 柘野浩史, 岡本誠, 高田真吾, 横井正, 中井睦郎, 槇野博史, 谷崎勝朗

    岡大三朝分院研究報告   2002年

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  • 男性ステロイド依存性喘息患者に対する4年間のエチドロネート投与の経験.

    柘野浩史, 岡本誠, 高田真吾, 横井正, 西田典数, 芦田耕三, 保崎泰弘, 光延文裕, 谷崎勝朗, 中井睦郎, 穐山恒雄, 長谷川寿一, 辻孝夫

    岡大三朝分院研究報告   2002年

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  • Effects of aging on bronchoalveolar lavage(BAL) cells in patients with asthma.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi Y, Tanizaki S

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002年

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  • The role of leukotrienes B4 (LTB4) and C4(LTC4) in pathophysiology of asthma in the elderly.Relationship to bronchial hyperresponsiveness and FEV1.0%.

    Mitusnobu F, Hosaki, Ashida K, Tsugeno H, Okamoto M, Nshida N, Takata S, Yokoi T, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002年

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  • %Low attenuation area (%LAA) of the lungs on high resolution computed tomography (HRCT),associated with pulmonary function in elderly patients with asthma.

    Mitusnobu F, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi Y, Nakai M, Tanizaki Y

    Ann Rep Misasa Med Branch, Okayama univ Med Sch   2002年

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  • Vertebral fracture and cortical bone changes in corticosteroid-induced osteoporosis.

    Tsugeno H, Fujita T, Goto B, Sugishita T, Hosaki Y, Ashida K, Mitsunobu F, Tanizaki Y, Shiratori Y

    Osteoporos Int   2002年

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  • The Effects of Spa Therapy on Asthma-Relationship of the generation of leukotrienes B4 (LTB4) and C4 (LTC4) and bronchial Hyperresponsiveness-

    Ashida K, Mitsunobu F, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Yokoi T, Takata S, Tanizaki Y

    J. Jpn Assoc Phys Med Baln Clim   2002年

  • 高齢者気管支喘息の病態におよぼす加齢および喫煙の影響について

    光延文裕, 保﨑泰弘, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 横井正, 高田真吾, 谷崎勝朗

    岡大三朝分院研究報告   2002年

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  • 体表面血流量の評価(その6) 末梢循環障害の非侵襲的早期診断と治療効果(2)

    保崎泰弘, 光延文裕, 芦田耕三, 柘野浩史, 岡本誠, 西田典数, 高田真吾, 横井正, 谷崎勝朗

    血栓と循環   2002年

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  • 多価不飽和脂肪酸と免疫機能

    岡本誠, 光延文裕, 芦田耕三, 谷崎勝朗

    臨床免疫   2002年

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  • 温泉医学・将来の展望-温泉を利用した健康増進および疾患予防 ③温泉療法による医療費の削減計画-疾患の治療と医療費の削減・具体例および医療統計からの検討-

    芦田 耕三, 岡本 誠

    日温気物医誌   2002年

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  • The formation of capsule and septum in human hepatocellular carcinoma

    M Ishizaki, K Ashida, T Higashi, H Nakatsukasa, T Kaneyoshi, K Fujiwara, K Nouso, Y Kobayashi, M Uemura, S Nakamura, T Tsuji

    VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY   438 ( 6 )   574 - 580   2001年6月

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    記述言語:英語   出版者・発行元:SPRINGER-VERLAG  

    The formation of fibrous capsule around the cancer nodule and of the septum in the tumor is frequently observed with the development of hepatocellular carcinoma MCC). We aimed to clarify how the capsule and septum were formed during the growth of HCC. Liver samples surgically resected from 25 patients with HCC were studied with in situ hybridization for type-I, -III, and -IV procollagen. Type-I and -III procollagen-expressing cells, mostly (x-smooth muscle actin (SMA)positive, were increased in the fibrous capsule and in the septum between HCC nodules. These cells were also found at the invasion front of HCC and around the necrotic cancer tissues. Type-IV procollagen gene expression was mainly observed in mesenchymal cells localized in both HCCs and non-cancerous liver. Cancer cells or hepatocytes did not express any of these procollagen genes. The present study reveals that the capsule and septum are mainly formed by oc-SMA-positive mesenchymal cells at the interface between two different tissues (e.g., cancer nodule vs non-cancerous liver or another cancer nodule). The wound healing occurs even in HCC. The capsule formation may result from interaction between tumor and host liver and interfere the growth and invasion of HCC.

    DOI: 10.1007/s004280000391

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  • Enhanced production of leukotrienes by peripheral leukocytes and specific IgE antibodies in patients with chronic obstructive pulmonary disease

    F Mitsunobu, T Mifune, Y Hosaki, K Ashida, H Tsugeno, M Okamoto, S Takata, Y Tanizaki

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   107 ( 3 )   492 - 498   2001年3月

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    記述言語:英語   出版者・発行元:MOSBY, INC  

    Background: How leukotrienes (LTs) and IgE-mediated allergy reflect clinical features in patients with chronic obstructive pulmonary disease (COPD) remains unclear.
    Objective: Our goal was to determine whether LTB4 and LTC4 would correlate with airway obstruction and whether IgE-mediated allergy would influence the generation of LTs and bronchial hyperresponsiveness in patients with COPD.
    Methods: We measured the pulmonary function, methacholine bronchial hyperresponsiveness, and generation of LTB4 and LTC4 from peripheral leukocytes stimulated with calcium ionophore A23187 in relation to the presence of specific IgE antibodies against inhalant allergens.
    Results: The leukocytes of patients with COPD generated significantly more LTB4 (with allergy, P < .001; without allergy, P < .001) and LTC4 (with allergy, P < .001; without allergy, P < .01) than the leukocytes of the control subjects. LTC4 production was significantly higher in the allergic COPD subjects than in the nonallergic COPD patients (P < .01), but the amount of LTB4 generated was not significantly different. FEV1 significantly correlated with the level of both LTB4 (with allergy, r = -0.556, P = .0375; without allergy; r = -0.731, P = .0046) and LTC4 (with allergy, r = -0.764, P = .0043; without allergy, r = -0.526, P = .0414) generation in COPD. The log(10) of the minimum dose of methacholine was significantly higher in COPD patients without allergy than in those with allergy (P < .05).
    Conclusion: Enhanced LT generation from peripheral leukocytes is observed in patients with COPD, and the presence of specific IgE antibodies against inhalant allergens enhances LTC4 generation, bronchial hyperresponsiveness, and the relationship between LTC4 generation and airway obstruction.

    DOI: 10.1067/mai.2001.112694

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  • Low-attenuation areas of the lungs on high-resolutionInfluence of age and disease severity on high resolution CT lung densitometry in asthma.

    Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Takata S, Tanizaki Y

    Thorax   2001年

  • Low-attenuation areas of the lungs on high-resolution computed tomography in asthma.

    Mitsunobu F, Mifune T, Ashida K, Hosaki Y, Tsugeno H, Okamoto M, Harada S, Tanizaki Y

    J. Asthma   2001年

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  • Correlation between efficacy of spa therapy and bronchial hyperresponsiveness in elderly patients with asthma.

    Mitsunobu F, Mifune T, Hosaki Y, Ashida K, Tsugeno H, Okamoto M, Nishida N, Takata S, Yokoi T, Ochi K, Tanizaki Y

    J. Jpn Assoc Phys Med Baln Clim   2001年

  • Oral glucocorticoid-induced fall in cortical bone volume and density in postmenopausal asthmatic patients.

    Tsugeno H, Goto B, Fujita T, Okamoto M, Mifune T, Mitsunobu F, Ashida K, Hosaki Y, Tsuji T, Tanizaki Y

    Osteoporos Int   2001年

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  • A patient with severe palindromic rheumatism and frequent episodes of pain.

    Takata S, Harada S, Mitsunobu F, Mifune T, Hosaki Y, Asida K, Tsugeno F, Okamoto M, Iwahashi M, Kawashima M, Yamamura M, Makino H, Tanizaki Y

    Intern Med   2001年

  • 気管支喘息および肺気腫に対する温泉療法.?最近9年間(1992年?2000年)の入院症例1271例の解析ー

    光延文裕, 御舩尚志, 保崎泰弘, 芦田耕三, 柘野浩史, 岡本 誠, 西田典数, 横井 正, 高田真吾, 谷崎勝朗, 越智浩二

    日温気物医誌   63,65?72   2001年

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  • 気管支喘息

    谷崎勝朗, 光延文裕, 御舩尚志, 保崎泰弘, 芦田耕三

    Medicament News   2001年

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  • 老年者の喘息

    谷崎勝朗, 御舩尚志, 光延文裕, 保崎泰弘, 芦田耕三

    医学と薬学   2001年

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  • The formation of capsule and septum in human hepatocellular carcinoma.

    Ishizaki M, Ashida K, Higashi T, Nakatsukasa H, Kaneyoshi T, Fujiwara K, Nouso K, Kobayashi Y, Uemura M, Nakamura S, Tsuji T

    Virchows Arch   2001年

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  • Effect of spa therapy on low attenuation area (LAA) of the lungs on high-resolution computed tomography (HRCT) and pulmonary function in patients with asthma.

    Ashida K, Mitsunobu F, Mifune T, Hosaki Y, Tsugeno H, Okamoto M, Nishida N, Yokoi T, Takata S, Tanizaki Y

    J. Jpn Assoc Phys Med Baln Clim   2001年

  • Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression

    S Terai, H Aoki, K Ashida, SS Thorgeirsson

    HEPATOLOGY   32 ( 2 )   357 - 366   2000年8月

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    記述言語:英語   出版者・発行元:W B SAUNDERS CO  

    The helix-loop-helix (HLH) family of transcriptional. regulatory proteins are key regulators in numerous developmental processes. The class I HLH proteins, such as E12 are ubiquitously expressed. Class II HLH proteins, such as MyoD, are expressed in a tissue-specific manner, Class I and II heterodimers can bind to E-boxes (CANNTG) and regulate lineage commitments of embryonic cells. In an attempt to identify partners for the E12 protein that may exert control during liver development, we performed the yeast 2-hybrid screen using an expression complementary DNA library from human fetal liver. A novel dominant inhibitory HLH factor, designated HHM (human homologue of maid), was isolated and characterized. HHM is structurally related to the Id family and was highly expressed in brain, pituitary gland, lung, heart, placenta, fetal liver, and bone marrow. HHM physically interacted with E12 in vitro and in mammalian cells. Comparison of the dominant inhibitory effects of HHM and Id2 on the binding of E12/MyoD dimer to an E-box element revealed a weaker inhibition by HHM. However, HHM but not Id2 specifically inhibited the luciferase gene activation induced by hepatic nuclear factor 4 (HNF4) promoter. The HHM was transiently expressed during stem-cell-driven regeneration of the liver at the stage in which the early basophilic foci of hepatocytes started to appear. These results suggest that HHM is a novel type of dominant inhibitory HLH protein that might modulate liver-specific gene expression.

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  • Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism

    M Okamoto, F Mitsunobu, K Ashida, T Mifune, Y Hosaki, H Tsugeno, S Harada, Y Tanizaki, M Kataoka, K Nilya, M Harada

    INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY   122 ( 2 )   137 - 142   2000年6月

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    記述言語:英語   出版者・発行元:KARGER  

    Background: Dietary sources of a-linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with asthma, as has been reported with the consumption of other long-chain n-3 fatty acids. Methods: The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n-3 fatty acids). Group A consisted of patients in whom the leucocyte generation of LTC4 was suppressed by dietary perilla seed oil. Group B consisted of those in whom LTC4 generation was not suppressed. Results: LTC4 generation by leucocytes decreased significantly in group A after 2 (p < 0.05) and 4 weeks (p < 0.05); conversely, it increased significantly in group B after 4 weeks (p < 0.05). The two study groups differed significantly in terms of LTC4 generation by leucocytes after 4 weeks of dietary supplementation (p < 0.05). Ventilatory parameters such as peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1) increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05). Values of PEF, FVC, FEV1 and maximum expiratory flow at 25% of the forced vital capacity ((V)over dot(25)) differed significantly between groups A and B prior to dietary supplementation. Serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol and phospholipid were significantly decreased by dietary supplementation in group A after 4 weeks. Serum levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL cholesterol and phospholipid differed significantly between the two study groups prior to dietary supplementation. Serum levels of triglyceride and LDL cholesterol differed significantly between the two study groups after 4 weeks of dietary supplementation. Conclusions: Dietary supplementation with perilla seed oil in selected patients with asthma suppresses the generation of LTC4 and is associated with clinical features such as respiratory function and lipometabolism. Copyright (C) 2000 S. Karger AG, Basel.

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  • Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma

    M Okamoto, F Mitsunobu, K Ashida, T Mifune, Y Hosaki, H Tsugeno, S Harada, Y Tanizaki

    INTERNAL MEDICINE   39 ( 2 )   107 - 111   2000年2月

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    記述言語:英語   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Objective The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes.
    Methods and Subjects 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups.
    Results The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p<0.05) and LTC4 at 2 weeks (p<0.05) after dietary supplementation. Significant increases in the value of PEF (p<0.05), FVC (p<0.01), FEV1.0 (p<0.05) and V-25 (p<0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p<0.05) and FEV1.0 (p<0.05) were observed between the two groups after 4 weeks of dietary supplementation.
    Conclusion These results suggest that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function.

    DOI: 10.2169/internalmedicine.39.107

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  • Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma

    Makoto Okamoto, Fumihiro Mitsunobu, Kozo Ashida, Takashi Mifune, Yasuhiro Hosaki, Hirofumi Tsugeno, Seishi Harada, Yoshiro Tanizaki

    Internal Medicine   39 ( 2 )   107 - 111   2000年

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    記述言語:英語   出版者・発行元:Japanese Society of Internal Medicine  

    Objective The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes. Methods and Subjects 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups. Results The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p&lt
    0.05) and LTC4 at 2 weeks (p&lt
    0.05) after dietary supplementation. Significant increases in the value of PEF (p&lt
    0.05), FVC (p&lt
    0.01), FEV1.0 (p&lt
    0.05) and V̇25 (p&lt
    0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p&lt
    0.05) and FEV1.0 (p&lt
    0.05) were observed between the two groups after 4 weeks of dietary supplementation. Conclusion These results suggest that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function.

    DOI: 10.2169/internalmedicine.39.107

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  • Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression.

    Terai S, Aoki H, Ashida K, Thorgeirsson SS

    Hepatology   2000年

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  • Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism

    International Archives of Allergy and Immunology   122 ( 2 )   137 - 42   2000年

     詳細を見る

  • IgE-mediated and age-related bronchial hyperresponsiveness in patients with asthma. relationship to family history of the disease.

    Age and Ageing   29 ( 3 )   215 - 20   2000年

     詳細を見る

  • Human homologue of maid : A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression

    Hepatology   32 ( (in press) 2 )   357 - 66   2000年

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  • Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography

    The European Respiratory Journal   14 ( 4 )   923 - 7   1999年

  • Bone mineral density in steroid-dependent asthma assessed by peripheral quantitative computed tomography

    H. Tsugeno, M. Nakai, M. Okamoto, S. Harada, T. Mifune, F. Mitsunobu, K. Ashida, Y. Hosaki, Y. Tanizaki, T. Tsuji

    European Respiratory Journal   14 ( 4 )   923 - 927   1999年

     詳細を見る

    記述言語:英語  

    Chronic use of systemic glucocorticoids results in progressive bone loss and pathologic fractures. This study identified the predictive variables for bone loss and used peripheral quantitative computed tomography (pQCT) to measure changes in cortical and trabecular bone in patients receiving systemic glucocorticoid therapy of prednisone 15.4 g. Eighty-four asthmatic patients were included in the study. Vertebral fractures were diagnosed via plain spinal radiograms, pQCT was used to measure cortical and trabecular bone mineral density. Multiple regression analysis identified variables with predictive value. The cumulative dose of glucocorticoid correlated with the bone mineral density (p&lt
    0.05) and the trabecular bone density (p&lt
    0.01). Among patients ≥65 yrs of age, the cumulative dose of glucocorticoid correlated with the occurrence of vertebral fractures (p&lt
    0.05), total bone mineral density (p&lt
    0.01) and cortical bone mineral density (p&lt
    0.01). Bone mineral density in the distal radius measured by pQCT and the vertebral bodies by axis QCT were correlated, regardless of whether systemic glucocorticoids were administered. Glucocorticoid administration not only decreases trabecular but also cortical bone mineral density. Since cortical bone provides strength and stiffness, it appears that the loss of cortical bone is responsible for the increased incidence of fracture seen in patients receiving systemic glucocorticoid therapy.

    DOI: 10.1034/j.1399-3003.1999.14d32.x

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  • Expression of alpha-fetoprotein and albumin genes in human hepatocellular carcinomas: Limitations in the application of the genes for targeting human hepatocellular carcinoma in gene therapy

    S Ohguchi, H Nakatsukasa, T Higashi, K Ashida, K Nouso, M Ishizaki, N Hino, Y Kobayashi, S Uematsu, T Tsuji

    HEPATOLOGY   27 ( 2 )   599 - 607   1998年2月

     詳細を見る

    記述言語:英語   出版者・発行元:W B SAUNDERS CO  

    For an approach of gene therapy for hepatocellular carcinoma (HCC), transcriptional regulatory sequence (TRS) of either alpha-fetoprotein (AFP) or albumin has been used for targeting cancer cells. To examine the feasibility of using TRSs of these genes for possible gene therapy of HCCs, the cellular distribution of AFP and albumin gene transcripts was studied in 25 cases of surgically removed human HCCs. AFP gene expression was observed in HCC nodules of 13 cases. The expression in HCC was heterogeneous, and the distribution of the transcripts was mostly sparse and spotty. The higher the serum AFP levels, the larger population of the AFP-expressing HCC cells tended to reflect. In noncancerous liver, a slight AFP expression was found by Northern blot analysis, but the transcripts were not detected in the liver sections. In contrast, albumin expression was found in all HCCs as well as in noncancerous hepatocytes. In HCC, the transcripts for albumin were distributed in cancer cells, and the expression varied with nodules. There were more albumin-expressing cancer cells than the AFP-expressing cells. Albumin expression was retained even in poorly differentiated HCC, although the intensity of the signal was not as strong as in more-differentiated HCCs. Metastatic HCC nodules revealed transcripts for both AFP and albumin genes, and those were clearly recognized in the lung tissue, These results suggest that, for gene therapy for HCCs, neither AFP nor albumin are ideal options for targeting HCC cells. AFP-TRS may be used as a transcriptional regulator in selected cases in which AFP gene expression is observed in the cancer nodules. The serum AFP level appears to be an important indicator in selecting cases. Albumin-TRS in conjunction with retroviral vector might be used in limited cases such as HCCs with no AFP expression. However, careful consideration must be taken, because albumin is constitutively expressed in normal hepatocytes, and AFP-expressing nonmalignant progenitor cells possibly exist.

    DOI: 10.1002/hep.510270239

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  • Different roles of histamine and leukofriene C4 in the airways between patients with atopic and non-atopic asthma

    Journal of asthma   35 ( 4 )   367 - 72   1998年

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  • Proliferating cell nuclear antigen and grade of Malignancy in small hepatocellular carcinema evaluation in us-guided specimens

    Hepato gastroenterogy   44 ( 13 )   245 - 50   1997年

     詳細を見る

  • Cellular distribution of transcripts for tissue inhibitor of metalloproteinases 1 and 2 in human hepatocellular carcinomas

    H Nakatsukasa, K Ashida, T Higashi, S Ohguchi, S Tsuboi, N Hino, K Nouso, Y Urabe, N Kinugasa, K Yoshida, S Uematsu, M Ishizaki, Y Kobayashi, T Tsuji

    HEPATOLOGY   24 ( 1 )   82 - 88   1996年7月

     詳細を見る

    記述言語:英語   出版者・発行元:W B SAUNDERS CO  

    The cellular distribution of tissue inhibitor of metalloproteinases (TIMP)-1, and TIMP-2 was studied by using in situ hybridization in surgically removed human hepatocellular carcinomas (HCCs) and cholangiocellular carcinomas (CCCs). The purpose of this study was to characterize the potential involvement of TIMPs in the development of HCCs and CCCs. All HCCs and CCCs expressed TIMPs, The distribution of transcripts for TIMPs in the tumors was mostly homogeneous, Expression of TIMPs in cancer cells was more intense than that in the surrounding noncancerous liver (either, cirrhosis, chronic hepatitis, or normal), and expression of TIMP-1 was stronger than that of TIMP-2. Expression of TIMPs varied among HCC nodules, but there was no obvious association between the expression level of TIMPs and differentiation stages or invasiveness of the HCCs, Transcripts for TIMPs were clearly demonstrated in the metastatic HCC nodules in the lung. Expression of TIMP-1 in CCC was strong, and small nodules of CCC were recognized in the liver. Immunohistochemical study for TIMP-1 revealed a consistent staining of the TIMP-1 protein with the transcripts. In the peritumoral histologically normal liver, which was not infected with either hepatitis B or C virus, expression of TIMP-1 was found in various cell types, but that of TIMP-2 was weak. Expression of TIMP-1 in hepatocytes revealed clear zonal distribution, These results suggest that TIMPs may act on modulating the matrix/tumor interaction and may play an important role in growth and invasion of HCCs and CCCs. Expression of TIMP-1 can be a marker of HCC metastasis to the lung, and also that of the extent of CCC invasion. Furthermore, the consistent expression of TIMPs in many cell types of the noncancerous liver suggests some unknown functional role that must be clarified.

    DOI: 10.1053/jhep.1996.v24.pm0008707287

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  • Telo merase as a tool for differential diagnosis of human hepato cellular carcinoma(共著)

    Cancer   2 ( 78 )   232 - 236   1996年

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  • Localization of 92 KDa gelatinase CMMP9)gene transripts in human hepatocellular carcinoma

    Ashida K, Nakatsukasa H, Higashi T, Ohguchi S, Hino N, Nouso K, Urabe Y, Yoshida K, Kinugasa N, Tsuji T

    American Journal of Pathology   6 ( 149 )   1803 - 1812   1996年

     詳細を見る

  • Telomere length in human liner cliseare

    Liver   6 ( 16 )   293 - 297   1996年

     詳細を見る

  • Localization of 92 KDa gelatinase CMMP9)gene transripts in human hepatocellular carcinoma

    American Journal of Pathology   6 ( 149 )   1803 - 1812   1996年

     詳細を見る

  • The Sec(]E89AB[)etion of procathepsin B and changes in its sugar moiety in cultured Hepatoma cells(共著)

    International Hepatology Communication   3   153   1995年

     詳細を見る

  • How are the capsule and septum formed during the growth of human hepatocellular earcinoma?

    HEPATOLOGY   22 ( 4 )   199   1995年

     詳細を見る

  • Cellular distribution of tissue inhibitor of metalloproteimases-1 and-2 transcripts in human hepatocellalar carunoma(共著)

    HEPATOLOGY   22 ( 4 )   192   1995年

     詳細を見る

  • Localization of 92 kDa Gelatinase(MMP9)Gene Transcripts in Human Hepatocellular carcinoma

    HEPATOLOGY   22 ( 4 )   192   1995年

     詳細を見る

  • LOCALIZATION of 92kDa Gelatinase gene transcripts in human hepatocellular carcinoma

    International hepatology communication   3   S148   1995年

     詳細を見る

  • Disuppearamce of Pulmonary Mefastasis by OK-432 Treadment in a case of Hepatocellular carinoma(共著)

    Acta med okayama   47 ( 4 )   289 - 292   1993年

     詳細を見る

▼全件表示

講演・口頭発表等

  • 水中運動の効果を評価し得る指標についての検討―東京の温泉療法医としての活動を通して(続報)―.

    第74回日本温泉気候物理医学会総会・学術集会.  2009年 

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  • 食塩含有人工炭酸泉浴の各種症状に及ぼす治療効果について(その3)―全身浴の血中アルドステロン濃度に及ぼす影響―.

    第74回日本温泉気候物理医学会総会・学術集会.  2009年 

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  • 自己免疫性肝炎の経過中に遠位型腎尿細管性アシドーシス(?型)及び低カリウム性横紋筋融解症を発症併した1例

    第38回日本肝臓用学会西部会  2009年 

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  • 食塩含有人工炭酸泉浴の各種症状に及ぼす治療効果について(その2):主観的治療効果と血流量の増加との関連について

    第73回日本温泉気候物理医学会総会・学術集会  2008年 

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  • 食塩含有人工炭酸泉浴の各種症状に及ぼす治療効果について(その1):急性および慢性効果の相違について

    第73回日本温泉気候物理医学会総会・学術集会  2008年 

     詳細を見る

  • COPD患者の運動耐用能・肺機能に対する温熱療法の有用性についての検討

    第48回日本呼吸器学会学術講演会  2008年 

     詳細を見る

  • 腹水が自然軽快を示し、脳結核腫、脊椎カリエスを合併した結核性腹膜炎の1例

    第98回日本内科学会中国地方会  2008年 

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  • 運動耐用能・肺機能の改善に温熱療法が有効と考えられたCOPD患者の一例

    第43回日本呼吸器学会中国四国地方会  2008年 

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  • 後期高齢者市中肺炎の臨床的検討―生存群と死亡群の比較検討―

    第50回日本老年医学会学術集会  2008年 

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  • 後期高齢者市中肺炎の予後因子に関する臨床的検討

    第104回日本内科学会講演会  2008年 

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  • 高齢者市中肺炎の臨床的研究―非高齢者、前期高齢者と後期高齢者の比較検討―

    第20回日本老年医学会中国地方会  2008年 

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  • 自己免疫性肝炎の経過中に遠位型腎尿細管性アシドーシス(?型)及び低カリウム性横紋筋融解症を発症併した1例

    第21回鳥取県中部肝疾患セミナー  2008年 

     詳細を見る

  • アトピー性皮膚炎患者におけるn-3系不飽和脂肪酸(PUFA)強化食の有効性についての検討

    第58回日本アレルギー学会秋季学術大会  2008年 

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  • 乳がん術後13年目に感に再発をきたした一例

    鳥取県中部腹部画像診断研究会  2008年 

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  • 慢性閉塞性肺疾患患者の運動耐容能に対する温泉療法の有効性の検討

    平成20年度鳥取県医師会秋季医学会  2008年 

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  • 肝機能異常を契機に発見されたサルコイドーシスの1例

    第99回日本内科学会中国地方会  2008年 

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  • 結核性腹膜炎の一例

    鳥取県中部腹部画像診断研究会  2008年 

     詳細を見る

  • 健常成人に発症したサイトメガロウィルス関連胃病変の1例

    日本内科学会中四国地方会  2007年 

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  • 温泉療法が慢性閉塞性肺疾患(COPD)患者の運動耐浴能に及ぼす影響に関する検討

    第72回日本温泉気候物理医学会総会・学術集会  2007年 

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  • 慢性閉塞性肺疾患患者における6分間歩行試験に対する温泉療法の有効性の検討

    日本呼吸器学会中国四国地方会  2007年 

     詳細を見る

  • 慢性好酸球性肺炎の2例

    第19回アレルギー学会春季臨床大会  2007年 

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  • 人工炭酸泉浴(バブ浴)を用いた足浴の下肢末梢循環に及ぼす影響について(その2)

    第72回日本温泉気候物理医学会総会・学術集会  2007年 

     詳細を見る

  • 当院における市中肺炎入院炎症の臨床的検討

    第47回日本呼吸器学会学術講演会  2007年 

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  • 肝細胞癌の経過中に肝原発腺扁平上皮癌を合併した1例

    第94回日本内科学会中国地方会  2006年 

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  • 気管支喘息に対するn-3系不飽和脂肪酸強化食の有効性

    第103回日本内科学会講演会  2006年 

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  • 薬物(sofalcone)の高齢者胃粘膜血流量に及ぼす影響の定量的観察

    第48回日本老年医学会学術集会・総会  2006年 

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  • 気管支喘息患者に対するn-3系不飽和脂肪酸強化食の血清ECP値に及ぼす影響

    第56回日本アレルギー学会秋季学術大会号  2006年 

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  • アルコール性肝障害として経過観察中80歳代にて発見された原発性胆汁性肝硬変の1例

    第18回日本老年学会中国地方会  2006年 

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  • 人工炭酸泉浴(バブ浴)を用いた足浴の下肢末梢循環に及ぼす影響について

    第71回日本温泉気候物理医学会総会・学術集会  2006年 

     詳細を見る

  • 温泉療法が慢性疾患患者の健康関連QOLに及ぼす影響に関する検討

    第71回日本温泉気候物理医学会総会・学術集会  2006年 

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  • 慢性呼吸器疾患患者に対する当院の運動浴および温熱治療を中心をしたリハビリテーション医療の治療効果に関する検討

    第46回日本呼吸器学界学術講演会  2006年 

     詳細を見る

  • 胃癌切除後に発症した顕微鏡的多発血管炎の1例

    第18回日本アレルギー学会春季臨床大会号  2006年 

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  • 高齢慢性疾患患者の健康関連のQOLに対する温泉療法の有効性に関する検討

    第48回日本老年医学会学術集会・総会  2006年 

     詳細を見る

  • 温泉療法による気管支喘息における肺の過膨張に対する改善作用-喫煙症例と非喫煙症例の比較検討-

    第70回日本温泉気候物理医学会総会・学術集会  2005年 

     詳細を見る

  • 気管支喘息患者における肺CT lung desity の経年的変化-喫煙歴の有無による比較検討

    第55回日本アレルギー学会秋季学術大会  2005年 

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  • 巨大嚢胞を合併したインスリノーマの1例

    第17回日本老年医学会中国地方会  2005年 

     詳細を見る

  • 気管支喘息のn-3系不飽和脂肪酸強化食による食事療法

    第55回日本アレルギー学会秋季学術大会  2005年 

     詳細を見る

  • 気管支喘息患者における肺CT lung densitometry に対する加齢の影響-4年間の経過観察-

    第47回日本老年医学会学術集会  2005年 

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  • Mefloquineが著効した熱帯熱マラリアの1例

    第92回日本内科学会中国地方会  2005年 

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  • 再発性肺腺癌に対してラジオ波熱凝固療法が有効であった1例

    第40回日本呼吸器学会中国四国地方会  2005年 

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  • 加齢における末梢循環血流量の経時的変化

    第47回日本老年医学会学術集会  2005年 

     詳細を見る

  • アクチノマイセス(放線菌)大腸炎の1例

    第93回日本内科学会中国地方会  2005年 

     詳細を見る

  • 胃癌切除後に発症したANCA関連血管炎の1例

    第40回日本呼吸器学会中国四国地方会  2005年 

     詳細を見る

  • 自己免疫性肝炎の経過中に遠位型腎尿細管性アシドーシス(1型)及び低カリウム性横紋筋融解症を合併した1例

    第93回日本内科学会中国地方会  2005年 

     詳細を見る

  • 重症アトピー性皮膚炎患者に対し当院の温泉療法が有効であった3例

    第17回日本アレルギー学会春季臨床大会  2005年 

     詳細を見る

  • 髄膜炎を契機に発見された進行大腸癌の1例

    第92回日本内科学会中国地方会  2005年 

     詳細を見る

  • 気管支喘息における長期間喫煙による病態的変化の若年者と高齢者の比較

    第17回日本アレルギー学会春季臨床大会  2005年 

     詳細を見る

  • 気管支喘息における肺の過膨張に対する温泉療法の改善効果についての検討

    第102回日本内科学会講演会  2005年 

     詳細を見る

  • 気管支喘息に対する食事療法-8週間のn-3系不飽和脂肪酸強化食による検討-

    第45回日本呼吸器学会  2005年 

     詳細を見る

  • 帯状疱疹後の神経痛に対する温泉療法の治療効果(その2)

    第70回日本温泉気候物理医学会総会・学術集会  2005年 

     詳細を見る

  • ケトプロフェン湿布剤により全身性麻疹様紅斑をきたした1例

    第17回日本アレルギー学会春季臨床大会  2005年 

     詳細を見る

  • 高齢気管支喘息患者に対する温泉療法の臨床効果に対する長期間喫煙の影響

    第45回日本呼吸器学会  2005年 

     詳細を見る

  • 当院における高齢者特発性間質性肺炎症例の臨床的検討

    第38回日本呼吸器学会中国四国地方会  2003年 

     詳細を見る

  • 気管支喘息の病態に対する喫煙の影響 IgE反応系,気道過敏性,ロイコトリエン産生能を中心に

    第15回日本アレルギー学会春季臨床大会  2003年 

     詳細を見る

  • 気管支喘息のIgE反応系,肺機能及び胸部HRCT所見に及ぼす長期喫煙の影響

    第100回日本内科学会総会  2003年 

     詳細を見る

  • 早期診断早期治療にて軽快したMPO-ANCA関連血管炎の一例

    第15回日本アレルギー学会春季臨床大会  2003年 

     詳細を見る

  • α-リノレン酸強化食の肺気腫に対する臨床効果

    第43回日本呼吸器学会総会  2003年 

     詳細を見る

  • 肺気腫に対するN-3系不飽和脂肪酸強化食の臨床効果

    第100回日本内科学会総会  2003年 

     詳細を見る

  • 喫煙歴を有する気管支喘息患者の臨床的特徴

    第43回日本呼吸器学会総会  2003年 

     詳細を見る

  • Influence of aging and cigarette smoking on elderly patients with asthma.

    7th Asia/Oceania Regional Congress of Gerontology  2003年 

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  • Non-invasive study for peripheral circulation aged patients with arteriosclerosis and evaluation on therapy.

    7th Asia/Oceania Regional Congress of Gerontology  2003年 

     詳細を見る

  • 肝硬変及び肝細胞癌加療中に著しい血小板減少症を併発した1例

    第89回日本内科学会中国地方会  2003年 

     詳細を見る

  • 感染を契機に急激に進行した高齢者特発性間質性肺炎の1例

    第15回日本老年医学会中国地方会  2003年 

     詳細を見る

  • 気管支喘息患者に対する温泉療法の薬剤費削減効果に対する検討

    第53回日本アレルギー学会総会  2003年 

     詳細を見る

  • Fluvoxamineによりセロトニン症候群をきたしたParkinson病の1例

    第88回日本内科学会中国地方会  2003年 

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    第45回日本老年医学会学術集会  2003年 

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  • Influence of long-term cigarette smoking on leukotriene production and bronchial hyperresponsiveness in asthmatics.

    99Th ATS/ALA International Conference,  2003年 

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  • 長期化学療法後にgefitinib(イレッサ)が奏功した術後再発肺腺癌の2例

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  • Characteristics of asthma in the elderly evaluated by high-resolution computed tomography and pulmonary function.

    13th ERS Annual Congress,  2003年 

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    第53回日本アレルギー学会総会  2003年 

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    第45回日本老年医学会学術集会  2003年 

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▼全件表示

共同研究・競争的資金等の研究

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    資金種別:競争的資金

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