2021/09/08 更新

写真a

マツザキ ヒデノブ
松﨑 秀信
MATSUZAKI Hidenobu
所属
岡山大学病院 助教
職名
助教
外部リンク

学位

  • 博士(歯学) ( 2013年3月   岡山大学 )

研究キーワード

  • 口腔癌

  • 放射線治療

  • 頭頸部癌

  • 歯科放射線学

研究分野

  • ライフサイエンス / 放射線科学

  • ライフサイエンス / 外科系歯学  / 歯科放射線学

所属学協会

 

論文

  • Pathological evaluation of radiotherapy and concomitant intraarterial cisplatin for maxillary sinus cancer 国際誌

    Takuma Makino, Tomoyasu Tachibana, Shin Kariya, Yusuke Matsui, Hidenobu Matsuzaki, Shohei Fujimoto, Yorihisa Orita, Kuniaki Katsui, Takao Hiraki, Yasuharu Sato, Susumu Kanazawa, Kazunori Nishizaki

    AURIS NASUS LARYNX   47 ( 5 )   881 - 886   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Objective: Since 2010, we have mainly performed surgical treatment following radiotherapy and concomitant intraarterial cisplatin (RADPLAT) for locally advanced maxillary sinus cancer (MSC). The present study investigated treatment results and pathological evaluations following RADPLAT for MSC.Methods: Pathological response to RADPLAT was evaluated using surgical specimens. Pathological response was graded in accordance with the classification method that Shimosato reported in 1964, as grade V (no tumor cells remain in any of section), grade IV, III, II, I, and 0. Five-year overall and disease-specific survival rates were estimated using Kaplan-Meier methods. Univariate analyses of correlations between recurrence of MSC and other clinicopathological parameters were evaluated using the chi-square or Fisher's exact tests.Result: 19 patients were enrolled in this study, 5 patients showed T3 disease and 14 had T4 disease. One patient demonstrated local recurrence and 3 patients experienced distant metastasis. The 5-year overall survival rate was 67.1% (T3, 50.0%; T4, 69.6%), and the 5-year disease-specific survival rate was 81.9% (T3, 100%; T4, 76.0%). Histological response was categorized as grade V in 9 cases. No significant risk factors for residual cancer were identified.Conclusion: Our study suggested that RADPLAT not only has a low risk of side effects, but also could represent an effective procedure for locally advanced MSC by pathological evaluation. Increasing the therapeutic intensity of RADPLAT might provide an effective modality to avoid highly invasive surgery. (C) 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.anl.2020.04.004

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  • Morphological characteristics of radicular cysts using computed tomography

    Shintaro Sukegawa, Hidenobu Matsuzaki, Naoki Katase, Hotaka Kawai, Takahiro Kanno, Jun-ichi Asaumi, Yoshihiko Furuki

    ODONTOLOGY   108 ( 1 )   74 - 83   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The purpose of this study was to evaluate computed tomography (CT) findings of radicular cysts with a focus on location, size, and condition of the surrounding bone. Subjects comprised 60 men and 86 women (mean age 47.2 years) with histopathologically confirmed radicular cysts who underwent CT examination between 2012 and 2014. Mesiodistal and buccolingual diameters were measured at the location where the lesion appeared to be largest on CT axial images. Of the 146 cases, 103 lesions were in the maxilla and 43 were in the mandible. Mesiodistal diameter of the maxillary lesions was significantly larger than that of the mandibular lesions. However, the ratio of mesiodistal diameter to buccolingual diameter in the mandible was significantly larger than that in the maxilla. Bone expansion was more significant in the maxilla than in the mandible. Mesiodistal and buccolingual diameters in only the maxilla and perilesional sclerotic radiolucency in images of both jaws were significantly associated with the severity of clinical symptoms. The findings suggest that radicular cysts in the maxilla are accompanied by bone expansion in the mesiodistal and buccolingual directions and those in the mandible progress in the mesiodistal direction without bone expansion. Clinical acute symptoms (pain and swelling) are correlated with lesion size in the maxilla; such a correlation is not clear for mandibular lesions, and discovery of mandibular lesions may, therefore, be delayed.

    DOI: 10.1007/s10266-019-00443-5

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  • 頭頸部癌患者に対する強度変調放射線治療中の体重減少に関する検討

    松﨑 秀信, 𠮷山 昌宏, 浅海 淳一, 木股 敬裕, 勝井 邦彰, 松﨑 久美子, 長本 幸子, 高原 陽子, 久保 和子, 梶清 友美, 水川 展吉, 假谷 伸

    頭頸部癌   46 ( 3 )   264 - 269   2020年

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    記述言語:日本語   出版者・発行元:日本頭頸部癌学会  

    頭頸部癌に対する放射線治療を受けた患者の体重減少の予測因子について,後方視的に検討を行った。2016年1月〜2018年12月までに初回治療として根治的強度変調放射線治療を受けた43例を対象とした。全例化学療法が併用されていた。38例で5%以上の体重減少を,15例で10%以上の体重減少を認めた。10%以上の体重減少に関する単変量解析では,年齢,頸部リンパ節転移の存在,肉眼的腫瘍体積の大きさ,予防域を含めた全ての計画標的体積の大きさ,口腔の最大線量,歯の状態(上顎および/あるいは下顎が無歯顎)が有意な因子であった。性別,BMI,PS,原発部位,T因子,糖尿病,胃瘻造設,口腔の平均線量は有意な因子ではなかった。多変量解析では,年齢,歯の状態が有意な因子であった。これらの結果から,強度変調放射線治療を受ける頭頸部癌患者では,若年者,有歯顎者であることが10%以上の体重減少の予測因子であることが示唆された。

    DOI: 10.5981/jjhnc.46.264

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  • Single institutional experience of radiation therapy for angiosarcoma of the scalp without cervical lymph node metastases: Impact of concurrent chemoradiation with maintenance chemotherapy using taxanes on patient prognosis 国際誌

    Hiroki Ihara, Tatsuya Kaji, Kuniaki Katsui, Tomoko Miyake, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Osamu Yamasaki, Masahiro Kuroda, Shin Morizane, Susumu Kanazawa

    MOLECULAR AND CLINICAL ONCOLOGY   11 ( 5 )   498 - 504   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    Cutaneous angiosarcoma is a rare aggressive malignant tumor. Concurrent chemoradiation (CCRT) with maintenance chemotherapy using taxanes is one of the primary treatments. The aim of the present study was to retrospectively analyze the efficacy of CCRT with maintenance chemotherapy using taxanes in localized angiosarcoma of the scalp without cervical lymph node metastases. A total of 19 patients treated with radiation therapy for localized angiosarcomas of the scalp without cervical lymph node metastases were enrolled. The overall survival (OS), progression-free survival (PFS), and local control (LC) rates were calculated using Kaplan-Meier analysis. Univariate analyses were performed for various potential prognostic factors for OS, PFS, and LC. The median radiation dose was 70 Gy (range, 60-70 Gy), and the fractional dose was 2 Gy. Radiation therapy alone, radiation therapy + interleukin-2, surgery + CCRT with maintenance chemotherapy, CCRT with maintenance chemotherapy, and CCRT without maintenance chemotherapy were administered to 2, 4, 2, 9 and 2 patients, respectively. The 1- and 3-year OS, PFS, and LC rates were 88 and 52%, 47 and 33%, and 74 and 56%, respectively. CCRT with maintenance chemotherapy and surgery were significant prognostic factors for PFS (P=0.036 and 0.025, respectively). Therefore, CCRT with maintenance chemotherapy using taxanes might be effective in treating localized angiosarcomas of the scalp without cervical lymph node metastases.

    DOI: 10.3892/mco.2019.1918

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  • Dose distribution of intensity-modulated proton therapy with and without a multi-leaf collimator for the treatment of maxillary sinus cancer: a comparative effectiveness study 国際誌

    Soichi Sugiyama, Kuniaki Katsui, Yuki Tominaga, Takahiro Waki, Norihisa Katayama, Hidenobu Matsuzaki, Shin Kariya, Masahiro Kuroda, Kazunori Nishizaki, Susumu Kanazawa

    RADIATION ONCOLOGY   14 ( 1 )   209 - 209   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    Background Severe complications, such as eye damage and dysfunciton of salivary glands, have been reported after radiotherapy among patients with head and neck cancer. Complications such as visual impairment have also been reported after proton therapy with pencil beam scanning (PBS). In the case of PBS, collimation can sharpen the penumbra towards surrounding normal tissue in the low energy region of the proton beam. In the current study, we examined how much the dose to the normal tissue was reduced by when intensity-modulated proton therapy (IMPT) was performed using a multi-leaf collimator (MLC) for patients with maxillary sinus cancer. Methods Computed tomography findings of 26 consecutive patients who received photon therapy at Okayama University Hospital were used in this study. We compared D2% of the region of interest (ROI; ROI-(D2%)) and the mean dose of ROI (ROI-(mean)) with and without the use of an MLC. The organs at risk (OARs) were the posterior retina, lacrimal gland, eyeball, and parotid gland. IMPT was performed for all patients. The spot size was approximately 5-6 mm at the isocenter. The collimator margin was calculated by enlarging the maximum outline of the target from the beam's eye view and setting the margin to 6 mm. All plans were optimized with the same parameters. Results The mean of ROI-(D2%) for the ipsilateral optic nerve was significantly reduced by 0.48 Gy, and the mean of ROI-(mean) for the ipsilateral optic nerve was significantly reduced by 1.04 Gy. The mean of ROI-(mean) to the optic chiasm was significantly reduced by 0.70 Gy. The dose to most OARs and the planning at risk volumes were also reduced. Conclusions Compared with the plan involving IMPT without an MLC, in the dose plan involving IMPT using an MLC for maxillary sinus cancer, the dose to the optic nerve and optic chiasm were significantly reduced, as measured by the ROI-(D2%) and the ROI-(mean). These findings demonstrate that the use of an MLC during IMPT for maxillary sinus cancer may be useful for preserving vision and preventing complications.

    DOI: 10.1186/s13014-019-1405-y

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  • Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen

    Yohei Takeshita, Shunsuke Okada, Miki Hisatomi, Hidenobu Matsuzaki, Hotaka Kawai, Yohei Noda, Jun Murakami, Mariko Fujita, Hitoshi Nagatsuka, Yoshinobu Yanagi, Junichi Asaumi

    ORAL RADIOLOGY   35 ( 3 )   335 - 340   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. A 70-year-old woman complained of noise and pain around the right temporomandibular joint. Osteomyelitis was suspected on the initial imaging examinations, although the findings were slightly atypical. However, a mass was observed in the right oropharyngeal wall on subsequent imaging examinations, and mandibular bone invasion, rather than osteomyelitis, was additionally suspected. The mass in the right oropharyngeal wall and right mandible was surgically excised. On postoperative histopathological examination, the mass was finally diagnosed as ACC. As tumor cells were also observed around the inferior alveolar nerve, mandibular bone invasion through the mandibular foramen was suspected. An oropharyngeal ACC invading the mandibular bone through the mandibular foramen is extremely rare. The present case suggests that bone invasion should be considered carefully with several imaging examinations when a malignant tumor such as ACC is observed around the jaw bone.

    DOI: 10.1007/s11282-018-0359-3

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  • Evaluation of Setup Errors at the Skin Surface Position for Whole Breast Radiotherapy of Breast Cancer Patients

    Kanae Miyahara, Masahiro Kuroda, Yuuki Yoshimura, Hideki Aoyama, Masataka Oita, Irfan Sugianto, Hidenobu Matsuzaki, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Susumu Kanazawa, Junichi Asaumi

    ACTA MEDICA OKAYAMA   72 ( 4 )   331 - 336   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We used image-processing software to analyze the setup errors at the skin surface position of breast cancer patients (n=66) who underwent post-operative whole breast irradiation at our hospital in 2014-2015. The sixty-six digital reconstructed radiographs (DRR) were created at the treatment planning for each patient. The lineacgraphies (n=377) were taken after the patients' setup during radiotherapy. The lineacgraphies and DRR were superimposed at the skin surface position for each patient with the image-processing software. We measured the deviations of the isocenters for the nipple-lung (X) direction and craniocaudal (Y) direction and the deviation of the rotation angle of the XY axes between the lineacgraphy and DRR on the superimposed images. The systematic error (mu, Sigma) and random error (sigma) were calculated from the X and Y deviations and rotation angle deviation. The mu of X, Y, and rotation angle were 0.01 mm, -1.2 mm, and 0.05 degrees, respectively. The Sigma of X, Y, and rotation angle were 1.8 mm, 1.5 mm, and 0.9 degrees, respectively. The s of X, Y, and rotation angle were 2.0 mm, 1.5 mm, and 1.0 degrees, respectively. Our analyses thus revealed that evaluations using image-processing software at the skin surface position in routine breast radiotherapy result in sufficiently small setup errors.

    DOI: 10.18926/AMO/56167

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  • 放射線性下顎骨壊死に関する検討

    松﨑 秀信, 木股 敬裕, 勝井 邦彰, 松﨑 久美子, 津村 宗近, 池田 篤司, 伊原木 聰一郎, 水川 展吉, 小野田 友男, 浅海 淳一

    頭頸部癌   44 ( 1 )   57 - 61   2018年

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    記述言語:日本語   出版者・発行元:日本頭頸部癌学会  

    当院で口腔および中咽頭癌に対する放射線治療を受けた60例(口腔癌42例,中咽頭癌18例)を対象とし,放射線性下顎骨壊死(以下ORN)のリスク因子について後方視的に検討を行った。ORNは7例(12%)で認められ,発生までの期間は1~53ヶ月(中央値15ヶ月)であった。下顎骨全体の検討では放射線治療前1ヶ月以内の抜歯の既往,平均線量(中央値51Gy)とV40およびV50(40Gy,50Gyが照射される下顎骨の体積)に有意差が認められた。片顎ずつの検討では,平均線量およびV40に有意差が認められた。多変量解析で下顎骨全体の検討での放射線治療前1ヶ月以内の抜歯の既往に有意差が認められ,片顎ずつの検討では認められなかったことから,要抜去歯を有する患者はORN発生のリスクが高いと考えられた。ORNを予防するためには,下顎骨に対する最大線量の制約に加え,平均線量の制約を組み込む必要があると考えられた。

    DOI: 10.5981/jjhnc.44.57

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  • The role of dentistry other than oral care in patients undergoing radiotherapy for head and neck cancer 国際誌

    Hidenobu Matsuzaki, Kumiko Tanaka-Matsuzaki, Fuminobu Miyazaki, Hideki Aoyama, Hiroki Ihara, Norihisa Katayama, Kuniaki Katsui, Kengo Himei, Tetsuo Takeuchi, Tomoo Onoda, Yoshihiro Kimata, Jun-Ichi Asaumi

    JAPANESE DENTAL SCIENCE REVIEW   53 ( 2 )   46 - 52   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    The usefulness of dental approaches, such as oral management, has gained recognition among patients treated for head and neck cancer. In particular, oral management plays a very important role before, during, and after treatment in patients undergoing radiotherapy, or a combination of both. However, specialized dentistry knowledge and techniques that are useful for patients undergoing radiotherapy for head and neck cancer have yet to be reported. Therefore, in this review article, our aim is to introduce dental approaches in radiotherapy for patients with head and neck cancer that have been developed and are currently being used at our institute. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of Japanese Association for DentalScience.

    DOI: 10.1016/j.jdsr.2016.09.003

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  • De novo myoepithelial carcinoma with multiple metastases arising from a submandibular salivary gland: A case report 国際誌

    Karina Cecilia Panelli Santos, Hidenobu Matsuzaki, Teruhisa Unetsubo, Shimo Tsuyoshi, Hitoshi Nagatsuka, Jun-Ichi Asaumi

    ONCOLOGY LETTERS   13 ( 4 )   2679 - 2683   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    Salivary gland carcinomas are rare tumors, representing similar to 0.5% of all malignancies. Myoepithelioma is also uncommon, representing similar to 1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases arising from a submandibular gland in a 71-year-old male patient and present the associated imaging findings. The patient was considered to have a de novo type of myoepithelial carcinoma, which is reportedly associated with higher malignancy than the transformation type of the disease (i.e., a malignant change from pleomorphic adenoma or myoepithelioma). This was reflected in the multiple lung and bone metastases sites and strong positivity for p53 and Ki-67.

    DOI: 10.3892/ol.2017.5783

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  • A massive osteonecrosis with Le Fort I-type pathological fracture, caused by bisphosphonate-related osteonecrosis of the jaw (BRONJ): A rare case report

    Shintaro Sukegawa, Takahiro Kanno, Naoki Katase, Hidenobu Matsuzaki, Akane Shibata, Yuka Takahashi, Yoshihiko Furuki

    JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY   28 ( 3 )   255 - 258   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Bisphosphonates (BPs) are useful drugs for the management of osteoporosis and metastatic bone disease, and are used to prevent skeletal-related events. However, the side effects of BPs, bisphosphonate-related osteonecrosis of the jaw (BRONJ), sometimes severely impairs patient quality of life. Here we report a case of severe BRONJ in the maxilla, which caused Le Fort I-type fracture-like bone fracture due to formation of a large sequestrum in the maxilla. (C) 2015 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.*

    DOI: 10.1016/j.ajoms.2015.10.001

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  • High-dose-rate brachytherapy using molds for lip and oral cavity tumors 国際誌

    Teruhisa Unetsubo, Hidenobu Matsuzaki, Mitsuhiro Takemoto, Kuniaki Katsui, Marina Hara, Norihisa Katayama, Takahiro Waki, Susumu Kanazawa, Jun-ichi Asaumi

    RADIATION ONCOLOGY   10   81 - 81   2015年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: High-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this retrospective study, we evaluated the outcome of this therapy and investigated its feasibility for lip and oral cavity tumors.Methods: Between May 2002 and December 2010, 17 patients (median age, 80.0 years) with histologically confirmed squamous cell carcinoma of the lip or oral cavity were treated by means of HDR brachytherapy using the mold technique after external beam radiotherapy (EBRT). Tumor sites included the buccal mucosa in eight cases, the gingiva in three cases, the lips in two cases, the floor of the mouth in two cases, and the hard palate in two cases. For all patients, EBRT (30 Gy/15 fractions), was performed before HDR brachytherapy. Two 6-Gy fractions were delivered twice daily for 2 days a week with an interval of 6 hours between the fractions. The total HDR brachytherapy dose was 24 Gy. Prior to EBRT, two patients with neck metastasis underwent neck dissection, and one patient with an exophytic tumor underwent tumor resection.Results: The median follow-up period was 53.4 (range, 4.8-83.4) months. Of the 17 patients, 14 (82.4%) achieved a complete response, and three (17.6%) displayed a partial response. The overall 3-and 5-year survival rates were both 68.8%, the 3-and 5-year disease-specific survival rates were both 86.7%, and the 3-and 5-year local control rates were both 54.1%. Seven patients developed local recurrence at a median time of 3.4 (range, 1.7-29.1) months after treatment. Nodal and lung metastases occurred separately in two patients. By the end of the follow-up period, two patients had died of the primary disease and four patients had died of other causes.Conclusions: Although there is a need to improve the technical aspects of the treatment protocol, HDR brachytherapy using the mold technique might be a therapeutic option for superficial lip or oral cavity tumors, especially in older patients who have a poor performance status or are in poor physical condition.

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  • Primary intraosseous squamous cell carcinoma of the maxilla possibly arising from an infected residual cyst: A case report 国際誌

    Shintaro Sukegawa, Hidenobu Matsuzaki, Naoki Katase, Takahiro Kanno, Toshiko Mandai, Yuka Takahashi, Jun-Ichi Asaumi, Yoshihiko Furuki

    ONCOLOGY LETTERS   9 ( 1 )   131 - 135   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare type of odontogenic carcinoma arising from the jawbone. Odontogenic cysts are true cysts that arise from the dental epithelium, which is associated with tooth formation. The epithelial lining of odontogenic cysts has the potential to transform into various types of odontogenic tumor; however, this transformation from an odontogenic cyst to a malignant tumor is rare. The definitive diagnosis for PIOSCC generally requires the observation of either features of squamous cell carcinoma (SCC) within the jawbone that are distinct from direct invasion from the surface oral epithelium, or evidence of SCC arising from odontogenic epithelium and from tumors that have metastasized to the jawbone from distant sites. In the present study, a case of PIOSCC of the maxilla is presented, which, based on the results of computed tomography and the clinical course, was hypothesized to have originated from an infected residual cyst.

    DOI: 10.3892/ol.2014.2644

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  • A new phantom and empirical formula for apparent diffusion coefficient measurement by a 3 Tesla magnetic resonance imaging scanner 国際誌

    Marina Hara, Masahiro Kuroda, Yuichi Ohmura, Hidenobu Matsuzaki, Tomoki Kobayashi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Seiichiro Ohno, Jun-Ichi Asaumi

    ONCOLOGY LETTERS   8 ( 2 )   819 - 824   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    The aim of this study was to create a new phantom for a 3 Tesla (3T) magnetic resonance imaging (MRI) device for the calculation of the apparent diffusion coefficient (ADC) using diffusion-weighted imaging (DWI), and to mimic the ADC values of normal and tumor tissues at various temperatures, including the physiological body temperature of 37 C. The phantom was produced using several concentrations of sucrose from 0 to 1.2 M, and the DWI was performed using various phantom temperatures. The accurate ADC values were calculated using the DWIs of the phantoms, and an empirical formula was developed to calculate the ADC values of the phantoms from an arbitrary sucrose concentration and arbitrary phantom temperature. The empirical formula was able to produce ADC values ranging between 0.33 and 3.02x10(-3) mm(2)/sec, which covered the range of ADC values of the human body that have been measured clinically by 3T MRI in previous studies. The phantom and empirical formula developed in this study may be available to mimic the ADC values of the clinical human lesion by 3T MRI.

    DOI: 10.3892/ol.2014.2187

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  • Diagnostic value of MR imaging for dentigerous cysts

    Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Emiko Saito Arita, Plauto Christopher Aranha Watanabe, Jun Murakami, Teruhisa Unetsubo, Mariko Fujita, Shunsuke Okada, Hidenobu Matsuzaki, Toshihiko Takenobu, Toru Wakasa

    ORAL RADIOLOGY   30 ( 1 )   13 - 19   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    It is known that the magnetic resonance (MR) imaging features of dentigerous cysts (DCs) are the same as those of other cysts. The cavities of DCs generally show low signal intensity (SI) on T1-weighted imaging (T1WI). However, in our experience, DCs often show high SI on T1WI, rendering them difficult to distinguish from keratocystic odontogenic tumors (KCOTs). In this study, we evaluated seven cases of DC and 23 cases of KCOT to assess whether MR imaging can provide additional information for the differential diagnosis of DC and KCOT.Two trials were evaluated. The first trial was an analysis of the cystic cavity SI on T1WI. To compare the SI between patients, we performed T1WI with contrast (T1c). The second trial analyzed the SI uniformity (U (I )) pound on T1WI, T2-weighted imaging (T2WI), and short inversion time inversion recovery (STIR) images of the cystic cavity, because it has been reported that an MR imaging feature of KCOT is heterogeneous SI. Statistical analyses were performed using the Mann-Whitney U test and a receiver operating characteristic (ROC) curve.The T1c values of DCs were significantly higher than those for KCOTs. The U (I ) pound values on T1WI and STIR images were significantly higher for DCs than for KCOTs. The T1c cutoff values (0.66 and 0.84) and U (I ) pound cutoff values for T1WI (82.1 %) and STIR images (79.8 %) were determined from the ROC analyses.T1c and U (I ) pound values provide useful additional information for the differential diagnosis of DC and KCOT.

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  • Fibrous dysplasia of the maxilla: a case report together with its conventional imaging and dynamic magnetic resonance imaging findings

    Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Teruhisa Unetsubo, Yoshinobu Yanagi, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   30 ( 1 )   105 - 110   2014年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    We previously reported that dynamic contrast-enhanced MRI parameters and time-signal intensity curves (TICs; also known as contrast index curves) are useful for the differential diagnosis of jawbone lesions. In particular, odontogenic fibroma and ossifying fibroma, which possess similar histopathological features (i.e., a mixture of hard and soft tissue components), display unique TIC patterns, and we consider that the TIC patterns of these lesions reflect their hard and soft tissue components. Therefore, fibrous dysplasia, which contains fibrous tissue and immature isolated trabeculae composed of woven bone, is expected to display an interesting TIC. The purpose of this study was to assess the utility of TICs for differentiating between the abovementioned lesions, which have similar histopathological components.

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  • In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Jurkat Cells Using Bio-phantoms

    Kazunori Katashima, Masahiro Kuroda, Masakazu Ashida, Takanori Sasaki, Takehito Taguchi, Hidenobu Matsuzaki, Jun Murakami, Yoshinobu Yanagi, Miki Hisatomi, Marina Hara, Hirokazu Kato, Yuichi Ohmura, Tomoki Kobayashi, Susumu Kanazawa, Sosuke Harada, Mitsuhiro Takemoto, Seiichiro Ohno, Seiichi Mimura, Junichi Asaumi

    ACTA MEDICA OKAYAMA   67 ( 6 )   359 - 367   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    It is well known that many tumor tissues show lower apparent diffusion coefficient (ADC) values, and that several factors are involved in the reduction of ADC values. The aim of this study was to clarify how much each factor contributes to decreases in ADC values. We investigate the roles of cell density, extracellular space, intracellular factors, apoptosis and necrosis in ADC values using bio-phantoms. The ADC values of bio-phantoms, in which Jurkat cells were encapsulated by gellan gum, were measured by a 1.5-Tesla magnetic resonance imaging device with constant diffusion time of 30 sec. Heating at 42 degrees C was used to induce apoptosis while heating at 48 degrees C was used to induce necrosis. Cell death after heating was evaluated by flow cytometric analysis and electron microscopy. The ADC values of bio-phantoms including non-heated cells decreased linearly with increases in cell density, and showed a steep decline when the distance between cells became less than 3 mu m. The analysis of ADC values of cells after destruction of cellular structures by sonication suggested that approximately two-thirds of the ADC values of cells originate from their cellular structures. The ADC values of bio-phantoms including necrotic cells increased while those including apoptotic cells decreased. This study quantitatively clarified the role of the cellular factors and the extracellular space in determining the ADC values produced by tumor cells. The intermediate diffusion time of 30 msec might be optimal to distinguish between apoptosis and necrosis.

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  • Swelling of the floor of the mouth in an infant 国際誌

    Hidenobu Matsuzaki, Naoki Katase, Norifumi Moritani, Marina Hara, Yoshinobu Yanagi, Jun-Ichi Asaumi

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   116 ( 4 )   392 - 397   2013年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    DOI: 10.1016/j.oooo.2012.03.025

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  • Conditions Inhibiting Eruption of Permanent First Molars

    Hidenobu Matsuzaki, Yoshinobu Yanagi, Naoki Katase, Hitoshi Nagatsuka, Marina Hara, Masakazu Ashida, Teruhisa Unetsubo, Akiko Sato, Mariko Fujita, Toshihiko Takenobu, Jun-ichi Asaumi

    PEDIATRIC DENTISTRY   35 ( 1 )   67 - 70   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ACAD PEDIATRIC DENTISTRY  

    Purpose: The purpose of this study was to evaluate the radiological and histopathological findings of 11 patients with unerupted first molars to verify the factors obstructing spontaneous eruption. Methods: The patients' clinical, radiological, and histopathological data were evaluated retrospectively to determine histopathological diagnosis, radiographic findings, methods of surgical management, and postoperative course. Results: This study involved 4 male and 7 female patients (mean age=9.5 years old). Nine cases involved the mandible. The patients' histopathological diagnoses included 3 odontogenic tumors, 2 odontogenic cysts, and 6 hyperplastic dental follicles. Radiographically, 10 cases showed characterless enlargement of the follicular space, while only 1 displayed radiopaque bodies. One patient with a tumor underwent enucleation, and 1 with a cyst underwent cystectomy and tooth extraction. The others underwent wide excision or partial excision of the surrounding tissue at the top of the impacted tooth. Tumor relapse was observed in 3 cases. Conclusion: Surgeons should perform aggressive treatment for patients with unerupted teeth because spontaneous eruption is rare in cases involving non-neoplastic lesions such as hyperplastic dental follicles.

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  • Diagnostic value of dynamic contrast-enhanced MRI for submucosal palatal tumors 国際誌

    Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka, Jun-ichi Asaumi

    EUROPEAN JOURNAL OF RADIOLOGY   81 ( 11 )   3306 - 3312   2012年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objectives: To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) for differentiating between benign and malignant tumors in the palate.Materials and methods: 26 patients with submucosal palatal tumors were preoperatively examined using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), and washout ratios (WR300 and WR600) were determined from contrast index curves. The submucosal palatal tumors were divided into two groups according to their Tmax values: the early enhancement group (Tmax < 300 s) consisted of 9 malignant tumors and 6 benign tumors, while the late enhancement group (Tmax >= 300 s) included one malignant tumor and 10 benign tumors. We compared the following DCE-MRI parameters between the benign and malignant tumors: CImax and Tmax in all cases and CImax, Tmax, and the washout ratios in the early enhancement group. In addition, we performed a regression analysis of the relationships between tumor size and DCE-MRI parameters; i. e., CImax, Tmax, and washout ratios, among the malignant salivary gland tumors and pleomorphic adenomas.Results: In all cases and the early enhancement group, significant differences in Tmax were detected between the benign and malignant tumors (P < 0.001 and P < 0.05, respectively), and the optimal Tmax cutoff value for differentiating between them was found to be 165 s. None of the other parameters displayed significant differences between the benign and malignant tumors. Only the WR600 of the pleomorphic adenomas was significantly correlated with tumor size (R-2 = 0.92, P < 0.001).Conclusions: Tmax is a useful parameter for distinguishing between benign and malignant submucosal palatal tumors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

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  • Solid-type primary intraosseous squamous cell carcinoma of the mandible: a case report with histopathological and imaging features 国際誌

    Hidenobu Matsuzaki, Naoki Katase, Tatsushi Matsumura, Marina Hara, Yoshinobu Yanagi, Hitoshi Nagatsuka, Seiji Iida, Jun-Ichi Asaumi

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   114 ( 5 )   E71 - E77   2012年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this article, we report a case of solid-type PIOSCC involving reactive bone formation in the mandible in a 60-year-old female patient together with its histopathological and imaging findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e71-e77)

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  • Ossifying fibroma of the maxilla: a case report including its imaging features and dynamic magnetic resonance imaging findings 国際誌

    Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Teruhisa Unetsubo, Jun-ichi Asaumi, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   114 ( 4 )   E139 - E146   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Ossifying fibroma (OF), a rare nonodontogenic tumor, is defined as a bone-related jawbone lesion. The main histopathological feature of OF is the replacement of bone by benign connective tissue. Ossifying fibroma usually occurs in the second to fourth decades of life and shows a predilection for females. Ossifying fibroma most commonly occurs in the mandible, and OF arising from the anterior part of the maxilla is rare. Ossifying fibromas display various radiographic findings, including varying degrees of radiolucency and radiopacity, depending on the proportions of their soft and hard tissue components. Depending on their components, it can be difficult to distinguish OF from other fibroosseous lesions and some odontogenic tumors by using conventional radiographs, computed tomography, and magnetic resonance imaging (MRI). We report a case of OF in the anterior maxilla in a 56-year-old man, together with its histopathological and imaging findings including the dynamic MRI findings. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e139-e146)

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  • Minor salivary gland tumors in the oral cavity: Diagnostic value of dynamic contrast-enhanced MRI 国際誌

    Hidenobu Matsuzaki, Yoshinobu Yanagi, Marina Hara, Naoki Katase, Jun-ichi Asaumi, Miki Hisatomi, Teruhisa Unetsubo, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

    EUROPEAN JOURNAL OF RADIOLOGY   81 ( 10 )   2684 - 2691   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Objective: To evaluate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for minor salivary gland tumors in the oral cavity.Materials and methods: Thirty-two patients with minor salivary gland tumors were examined preoperatively using DCE-MRI. Their maximum contrast index (CImax), time of CImax (Tmax), Tpeak; i.e., the time that corresponded to the CImax x 0.90, and washout ratios (WR300 and WR600) were determined from contrast index (CI) curves. We compared these parameters between benign and malignant tumors and among the different histopathological types of minor salivary gland tumors. Then, we categorized the patients' CI curves into four patterns (gradual increase, rapid increase with high washout ratio, rapid increase with low washout, and flat).Results: Statistically significant differences in Tmax (P = 0.004) and Tpeak (P = 0.002) were observed between the benign and malignant tumors. Regarding each histopathological tumor type, significant differences in Tmax (P < 0.001), Tpeak (P < 0.001), and WR600 (P = 0.026) were observed between the pleomorphic adenomas and mucoepidermoid carcinomas. It was difficult to distinguish between benign and malignant tumors using our CI curve classification because that two-thirds of the cases were classified into the same type (gradual increase).Conclusion: The DCE-MRI parameters of minor salivary gland tumors contributed little to their differential diagnosis compared with those for major salivary gland tumors. During the diagnosis of minor salivary gland tumors, Tmax is useful for distinguishing between benign and malignant tumors. (c) 2011 Elsevier Ireland Ltd. All rights reserved.

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  • Imaging features of adenoid cystic carcinoma of the tongue with dedifferentiated components: a case report

    Yoshinobu Yanagi, Hidenobu Matsuzaki, Naoki Katase, Tomoo Onoda, Marina Hara, Teruhisa Unetsubo, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   28 ( 2 )   157 - 165   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Adenoid cystic carcinoma (ACC) of the head and neck region is an uncommon epithelial tumor of the major and minor salivary glands. In the oral region, although ACC arising from the minor salivary glands is the second most commonly found tumor in the tongue base, its occurrence in the anterior part of the tongue is rare. Histopathologically, ACC is categorized into three growth patterns (tubular, cribriform, and solid types) and three histologic grades (I-III) that are based on the proportions of these patterns. According to this classification, tubular- and cribriform-type ACCs are considered to be lower grade lesions, while solid-type ACCs are considered to be higher grade lesions. A fourth histopathological type has recently been reported by some authors, namely, dedifferentiation or high-grade transformation of ACC. However, very few studies have focused on the imaging features of these ACCs. We report here the case of a 63-year-old female patient with ACC of the tongue with dedifferentiated components, together with the radiological images and pathological features of this ACC.

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  • Unusual MRI appearance of a lymphoepithelial cyst in the parotid gland

    Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Marina Hara, Mariko Fujita, Teruhisa Unetsubo, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   28 ( 2 )   133 - 139   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Lymphoepithelial cysts, which are also known as branchial cleft cysts, commonly occur in the lateral cervical region. Lymphoepithelial cysts arising in the parotid gland are rare and must be distinguished from parotid gland tumors. Magnetic resonance imaging (MRI) is useful for diagnosing parotid gland lesions, and MR images of lymphoepithelial cysts typically display a cystic mass that appears homogeneously hypointense on T1-weighted images and homogeneously hyperintense on T2-weighted images. However, some parotid gland tumors that retain fluid in their inner sections show similar MRI findings to lymphoepithelial cysts. Furthermore, lymphoepithelial cysts are sometimes modified by inflammation, and these cases are hard to diagnose. We report the case of a 59-year-old female with a lymphoepithelial cyst that arose in the parotid gland. The cyst had been affected by inflammation and displayed atypical imaging findings, i.e., heterogeneous signal intensity of the liquid component and the presence of a well-enhanced capsule-like structure surrounding the liquid component. In addition, we compare the MRI findings of this case with those of two other cervical lymphoepithelial cysts.

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  • Central odontogenic fibroma of the jawbone: 2 case reports describing its imaging features and an analysis of its DCE-MRI findings 国際誌

    Marina Hara, Hidenobu Matsuzaki, Naoki Katase, Yoshinobu Yanagi, Teruhisa Unetsubo, Jun-Ichi Asaumi, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   113 ( 6 )   E51 - E58   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Odontogenic fibroma (OF) is a rare nonepithelial benign tumor arising from the odontogenic mesenchymal tissue in the jawbone. OFs are topographically categorized into 2 types, the central type and peripheral type, and are histopathologically divided into the epithelium-poor type and epithelium-rich type. The radiological findings of central OF commonly include a uni- or multilocular radiolucent area with a well-defined margin, which are similar to those of cysts and other benign tumors of the jawbone. Therefore, it is difficult to distinguish OF from these jawbone lesions on radiographs because of their noncharacteristic radiological findings. In this article, we report the cases of 2 patients with central OF who underwent magnetic resonance (MR) examinations and describe the usefulness of dynamic contrast-enhanced MR imaging for diagnosing OF. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:e51-e58)

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  • In Vitro Assessment of Factors Affecting the Apparent Diffusion Coefficient of Ramos Cells Using Bio-phantoms

    Takanori Sasaki, Masahiro Kuroda, Kazunori Katashima, Masakazu Ashida, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Seiichiro Ohno, Hirokazu Kato, Susumu Kanazawa

    ACTA MEDICA OKAYAMA   66 ( 3 )   263 - 270   2012年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkitt's lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 gm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values.

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  • Two-piece customized mold technique for high-dose-rate brachytherapy on cancers of the buccal mucosa and lip 国際誌

    Hidenobu Matsuzaki, Mitsuhiro Takemoto, Marina Hara, Teruhisa Unetsubo, Yoshinobu Yanagi, Kuniaki Katsui, Norihisa Katayama, Kotaro Yoshio, Toshihiko Takenobu, Masahiro Kuroda, Susumu Kanazawa, Jun-Ichi Asaumi

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   113 ( 1 )   118 - 125   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective. High-dose-rate (HDR) brachytherapy using a customized mold is a minimally invasive treatment for oral cancer; however, it is difficult to use this technique for buccal and lip cancers involving the commissura labiorum, owing to its anatomic form. The purpose of this study was to introduce an improved customized mold consisting of 2 pieces to allow the fixation of molds to these sites.Study design. Five patients with buccal carcinoma and 1 patient with lip carcinoma were treated with this technique after external beam radiotherapy. One patient with neck metastasis underwent both neck dissection and partial tumor resection before HDR brachytherapy.Results. At the end of the follow-up period, 5 patients had no tumor recurrence, and 1 patient had suffered local recurrence.Conclusions. Our technique is a viable therapeutic option for patients with buccal and lip carcinomas for whom the therapeutic modalities are limited by age, performance status, and other factors. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:118-125)

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  • Magnetic resonance imaging (MRI) and dynamic MRI evaluation of extranodal non-Hodgkin lymphoma in oral and maxillofacial regions 国際誌

    Hidenobu Matsuzaki, Marina Hara, Yoshinobu Yanagi, Jun-ichi Asaumi, Naoki Katase, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY   113 ( 1 )   126 - 133   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Objective. The purpose of this study was to evaluate the diagnostic value of magnetic resonance imaging (MRI), especially dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), in extranodal non-Hodgkin lymphoma (NHL) of oral and maxillofacial regions.Study design. Thirteen cases with extranodal NHL were examined using MRI. T1-weighted images (T1WI) and T2-weighted images (T2WI) or short TI inversion recovery (STIR) images were obtained in all cases. Contrast-enhanced images and DCEM-RI were acquired in 10 and 7 cases, respectively. On DCE-MRIs, we analyzed the parameters as follows: contrast index at maximal contrast enhancement (CImax), maximum contrast index (CI) gain/CImax ratio, and washout ratios (WR300, WR600, and WR900) at 300, 600, and 900 seconds after contrast medium injection.Results. The signal intensity of all lesions was hypointense to isointense on T1WIs and showed variable contrast enhancement patterns. On T2WIs and STIR images, the signal intensity was isointense to hyperintense in almost all cases. Analysis of DCE-MRI parameters in extranodal NHLs resulted in the identification of 4 types of CI curves according to CImax and WR: (1) CImax greater than 2.0 and WR900 greater than 40%, (2) CImax greater than 2.0 and WR900 less than 40%, (3) CImax less than 1.5 and WR900 greater than 40%, and (4) CImax less than 1.5 and WR900 greater than 40%.Conclusions. The signal intensities on MRI were not specific to extranodal NHL and resembled those of other tumor types. When CImax was less than 1.5 or WR900 was less than 40%, these parameters contributed to diagnosis in extranodal NHLs. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 113: 126-133)

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  • Primary extranodal lymphoma of the maxilla: a case report with imaging features and dynamic data analysis of magnetic resonance imaging 国際誌

    Hidenobu Matsuzaki, Naoki Katase, Marina Hara, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Toshihiko Takenobu, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   112 ( 3 )   E59 - E69   2011年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MOSBY-ELSEVIER  

    Malignant lymphoma is the second-most common malignancy in the head and neck region. Waldeyer's ring is the most common site of extranodal Hodgkin's lymphoma (NHL) in that region, and a small percentage of primary extranodal NHL occurs in the oral cavity. The most common sites of extranodal NHL in the oral region are the palate and maxilla, and nearly half of extranodal NHL cases arise from bone. It is difficult to diagnose extranodal NHL because of the variety of its radiological features. We report a case of primary extranodal NHL of the maxilla in a 68-year-old female patient with atypical imaging findings, along with the results of analysis of dynamic magnetic resonance imaging (MRI). (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e59-e69)

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  • Ameloblastic carcinoma: a case report with radiological features of computed tomography and magnetic resonance imaging and positron emission tomography 国際誌

    Hidenobu Matsuzaki, Naoki Katase, Marina Hara, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Miki Hisatomi, Hironobu Konouchi, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   112 ( 1 )   E40 - E47   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MOSBY-ELSEVIER  

    Ameloblastic carcinoma is a rare malignant odontogenic carcinoma that has metastatic potential, and because of its rare incidence, there are few reports focusing on its radiologic imaging. If it shows aggressive appearances, it can be diagnosed as malignant tumor. But in case of negative appearance, it is difficult to distinguish ameloblastic carcinoma from ameloblastoma. We report a case of ameloblastic carcinoma of the maxilla in a 76-year-old female patient with radiologic images and pathologic features. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 112: e40-e47)

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  • インプラントを希望して岡山大学歯学部を受診した患者の初診時パノラマX線像の検討

    久富 美紀, 竹信 俊彦, 若狭 亨, 此内 浩信, 柳 文修, 松崎 秀信, 村上 純, 畦坪 輝寿, 浅海 淳一

    岡山歯学会雑誌   30 ( 1 )   11 - 16   2011年6月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    2008年1月〜2010年9月にインプラント治療を希望して受診しパノラマX線撮影が行われた患者500例を対象に、患者背景やX線所見について統計学的に検討した。性別は男性192例(38%)、女性308例(62%)であった。年齢は17〜87歳(平均57.4歳)で、50〜60歳代が多く69%を占めていた。インプラント希望歯数は、1本の患者が125例(25%)、2本が114例(23%)、3本が79例(16%)、4本が54例(11%)、5本以上が128例(26%)であった。インプラント希望部位を年齢別にみると、若年層で前歯部が多く、高齢者で臼歯部が多いという特徴が認められた。X線で歯欠損以外の異常所見を認めたものが325例(65%)あり、内訳は歯根膿瘍307例(61%)、歯根膿瘍と他の異常所見が重複しているもの24例(5%)、歯根膿瘍以外の所見18例(4%)であった。歯根膿瘍は1患者平均2.05本認め、インプラント希望部位の隣在歯に認めたものが79例(16%)あった。

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  • Diagnostic value of dynamic contrast-enhanced MRI for unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2-weighted or STIR MR images 国際誌

    Miki Hisatomi, Yoshinobu Yanagi, Hironobu Konouchi, Hidenobu Matsuzaki, Toshihiko Takenobu, Teruhisa Unetsubo, Jun-ichi Asaumi

    ORAL ONCOLOGY   47 ( 2 )   147 - 152   2011年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Typical MR images of ameloblastomas on T2-weighted image (WI) or short inversion time inversion-recovery (STIR) show multiple bright high-signal-intensity loci on a high-signal-intensity background. Unilocular cystic-type ameloblastomas show homogeneously bright high signal intensity on T2WI or STIR as a water-like signal intensity. Therefore, it is difficult to distinguish unilocular cystic-type ameloblastoma from other cystic lesions such as keratocystic odontogenic tumors, radicular cysts (residual cysts) and dentigerous cysts only on the basis of MRI signal intensity. In the present study, we evaluated whether contrast-enhanced (CE)-T1WI and dynamic CE-MRI (DCE-MRI) could provide additional information for differential diagnosis in unilocular cystic-type ameloblastoma. Images from 12 cases of suspected unilocular cystic-type ameloblastoma were evaluated in the present study. Of them, 5 had areas suspected of indicating a solid component on T1WI and T2WI (or STIR). Ten had undergone additional CE-T1WI and DCE-MRI. On 5 of 10 cases of CE-T1WI, a tiny enhancement area was detected. On 6 of 10 DCE-images, a time-course enhanced area which was suspected to be a solid component was detected. CE-T1WI was helpful in the diagnosis of ameloblastoma because the tiny enhanced areas were taken to indicate possible solid components. Moreover, the rim-enhancement area on CE-T1WI could be divided into small regions of interest, and some of these showed slightly increased enhancement on DCE-MRI, which was taken to indicate a solid component and/or intramural nodule with focal invasion of ameloblastoma tissue. DCE-MRIs of the four remaining cases, which provided no clues to the diagnosis of ameloblastoma in the manner of the above descriptions, showed thicker rim enhancement than odontogenic cysts. Thus, CE-T1WI and DCE-MRI were helpful in the differential diagnosis of unilocular cystic-type ameloblastomas with homogeneously bright high signal intensity on T2WI or STIR. (C) 2010 Elsevier Ltd. All rights reserved.

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  • The utility of three-dimensional dynamic contrast-enhanced magnetic resonance imaging in delineating vessel-rich regions: a case report of an aneurysmal bone cyst of the mandible

    Yoshinobu Yanagi, Mariko Fujita, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Naoki Katase, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL RADIOLOGY   26 ( 2 )   110 - 115   2010年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Aneurysmal bone cysts (ABCs) are classified as bone-related lesions based on the 2005 World Health Organization histological classification of odontogenic tumors. Most ABCs are diagnosed using a combination of conventional radiography, computed tomography, magnetic resonance imaging (MRI), and digital subtraction angiography. ABCs should be differentiated from true cysts or other pseudocysts because their treatment is different. Additionally, unlike other cysts, ABCs pose a hemorrhagic risk in surgery; thus, preoperative evaluation of intralesional blood flow is required. Here we report a case of a mandibular ABC in a 39-year-old woman and focus on its dynamic contrast-enhanced MRI (DCE-MRI) features. On DCE-MRI, the lesion was divided into two areas according to the enhancement pattern: the blood-pooling and blood-flow areas. The series of DCE-MR images of the blood-pooling area showed marked enhancement of the margin, but no enhancement in the inner part of the cavity. Additionally, the time-signal intensity curve (TIC) demonstrated no change in the signal intensity (SI) until approximately 15 min after gadolinium-diethylenetriamine penta-acetic acid (Gd-DTPA) administration. In contrast, the series of DCE-MR images of the blood-flow area exhibited marked enhancement in the cyst cavity in the early phase. The TIC showed a rapid increase in SI in the early phase, followed by a rapid decrease until 150 s, and finally a gradual decrease until approximately 15 min after Gd-DTPA administration. Thus, in the current patient, preoperative DCE-MRI clearly delineated the vessel-rich area within the lesion.

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  • Usefulness of MRI and dynamic contrast-enhanced MRI for differential diagnosis of simple bone cysts from true cysts in the jaw 国際誌

    Yoshinobu Yanagi, Jun-ichi Asaumi, Teruhisa Unetsubo, Masakazu Ashida, Toshihiko Takenobu, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Naoki Katase, Hitoshi Nagatsuka

    ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY   110 ( 3 )   364 - 369   2010年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MOSBY-ELSEVIER  

    Introduction. It can be difficult to differentiate simple bone cysts (SBCs) from true cysts in the jaw when these lesions appear unilocular. The present study reports the MR imaging of subjects with SBCs and describes the diagnostic value of the MRI findings.Materials and methods. Ten subjects with SBCs in the jaw were examined using MRI. T1- and T2-weighted images (T1WI, T2WI) were obtained, and contrast-enhanced images and dynamic contrast-enhanced MRI (DCE-MRI) were acquired.Results. In all cases, the contrast-enhanced T1WI acquired approximately 6 minutes after the administration of GdDTPA showed marked enhancement of the margin and slight enhancement of the inner part of the cyst cavity. In all cases, the time-signal intensity (SI) curves show a gradual increase in the SI until approximately 15 minutes after the administration of Gd-DTPA. These findings might not be observed on the DCE-MRIs of the other true cysts with epithelial lining that show no enhancement in a cavity.Conclusion. MRI, especially DCE-MRI, can provide useful information for distinguishing SBCs from other cysts. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:364-369)

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  • A new phantom using polyethylene glycol as an apparent diffusion coefficient standard for MR imaging 国際誌

    Ryohei Matsuya, Masahiro Kuroda, Yoshitsugu Matsumoto, Hirokazu Kato, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Takanori Sasaki, Tetsuro Sei, Kengo Himei, Kuniaki Katsui, Norihisa Katayama, Mitsuhiro Takemoto, Susumu Kanazawa, Seiichi Mimura, Seiichiro Oono, Takuichi Kitayama, Seiji Tahara, Keiji Inamura

    INTERNATIONAL JOURNAL OF ONCOLOGY   35 ( 4 )   893 - 900   2009年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    In recent years, magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) has seen wide clinical use, such as for early detection of cerebrovascular diseases and whole body screening for tumors. The apparent diffusion coefficient (ADC) standard phantom, which mimics the ADC values of several lesions in the body, is indispensable for the development of new pulse sequences for DWI, such as diffusion-weighted whole-body imaging with background body-signal suppression (DWIBS). However, information on the ADC values of the previously reported ADC standard phantoms is limited, because these phantoms were made using only a few different materials at a limited range of concentrations, and the ADC values were measured only at certain temperatures. It has been considered difficult, if not impossible, to create a phantom that provides arbitrary ADC values, because it is difficult to calculate the concentrations of the materials and the temperature at ADC measurement. In this study, we used polyethylene glycol (PEG) as a phantom material, and developed an empirical formula to calculate the PEG concentration at any measurement temperature to obtain arbitrary ADC values of the phantom. DWI images of phantoms made using seven different PEG concentrations were taken under heating from 17 to 46 degrees C at 1 degrees C intervals. Using ADC values calculated from these DWI images, we developed two empirical formulas: i) an empirical formula to calculate the ADC values of phantoms made using any PEG concentration at any measurement temperature; and ii) an empirical formula to calculate PEG concentrations to obtain arbitrary ADC values at any measurement temperature. We inspected the accuracy of these empirical formulas by newly made PEG phantoms. A comparison between the ADC values calculated with the empirical formulas and the measured ADC values confirmed the high accuracy of these formulas. PEG phantoms are safe, inexpensive and easy to make, compared with the previously reported ADC standard phantoms. Our empirical formulas enable us to calculate PEG concentrations that provide arbitrary ADC values at any measurement temperature. The empirical formulas could be used within a range of ADC values from 0.37x10(-3) to 3.67x10(-3) mm(2)/s, PEG concentrations from 0 to 120 mM, and measurement temperatures from IS to 45 degrees C. Using these formulas, it would be possible to make standard phantoms that mimic the ADC values of any clinical lesions. The PEG phantom might thus be an excellent new ADC standard phantom for MRI with DWI.

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  • In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology 国際誌

    Yoshitsugu Matsumoto, Masahiro Kuroda, Ryohei Matsuya, Hirokazu Kato, Koichi Shibuya, Masataka Oita, Atsushi Kawabe, Hidenobu Matsuzaki, Junichi Asaumi, Jun Murakami, Kazunori Katashima, Masakazu Ashida, Takanor Sasaki, Tetsuro Sei, Susumu Kanazawa, Seiichi Mimura, Seiichiro Oono, Takuichi Kitayama, Seiji Tahara, Keiji Inamura

    ONCOLOGY REPORTS   22 ( 3 )   641 - 648   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    Diffusion-weighted magnetic resonance imaging (MRI) is frequently used clinically, and is available for the whole-body screening for tumors. The exact mechanism by which the apparent diffusion coefficient (ADC) value decreases in tumorous tissue remains unclear, although various theories have been proposed, including intracellular and extracellular factor theories. It is impossible to distinguish each factor in the intracellular and extracellular spaces as the source of MR signal generation by means of conventional comparison between MR images and pathological specimens. Other factors which have been reported to affect ADC include cellularity and cellular edema of human tissues, and temperature of phantoms at the time of measurement. We employed a new technique that enables cellular MR imaging using a newly developed bio-phantom containing a living culture tumor cell line, Jurkat-N1. We investigated possible reasons for observed decreases in ADC values for tumors, and we considered the contribution of both the intracellular and extracellular space to such a decrease. The ADC values of the bio-phantom increased with increasing heat exposure from 27 to 45 degrees C. ADC values also increased after the destruction by sonication of tumor cell membranes. ADC values decreased as cellularity increased in the bio-phantorn. ADC values decreased due to cellular edema caused by a low salt concentration in the bio-phantom. Changes in pressure in the bio-phantom had no effect on the observed ADC values. We calculated both the intracellular ADC and extracellular ADC values using the ADC values, cellularity, and cellular volume of Jurkat-N1 cells in the bio-phantom. The extracellular ADC values in the bio-phantom were estimated to be lower than the ADC value of distilled water. These results indicate that not only intracellular ADC values, but also extracellular ADC values contribute to the determination of the ADC values of bio-phantoms. This is the first report to have examined the contribution of intracellular and extracellular space on the ADC values of bio-phantoms containing cultured tumor cells.

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  • Dynamic contrast-enhanced magnetic resonance imaging for estimating tumor proliferation and microvessel density of oral squamous cell carcinomas 国際誌

    Teruhisa Unetsubo, Hironobu Konouchi, Yoshinobu Yanagi, Jun Murakami, Masae Fujii, Hidenobu Matsuzaki, Miki Hisatomi, Hitoshi Nagatsuka, Jun-ichi Asaumi

    ORAL ONCOLOGY   45 ( 7 )   621 - 626   2009年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We evaluated the relationship between histopathological prognostic factors, tumor proliferation microvessel density (MVD), and enhancement parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in oral squamous cell carcinoma (SCC). Twenty-eight T2 and T3 patients with primary oral SCC underwent DCE-MRI using three-dimensional fast imaging with a steady-state precession sequence. Tumor cell proliferation and MVD of all surgical specimens were evaluated using immunohistochemical staining with CD34 and the antibody for proliferating cell nuclear antigen (PCNA). Regression analysis was used to statistically analyze the relationship between the PCNA labeling index or MVD and each of three DCE-MRI parameters: maximum CI (CI-max), maximum CI gain (CI-gain) and the CI-gain / CI-max ratio. The PCNA labeling index and MVD showed significant correlations with the CI-gain/CI-max ratio (P = 0.0012, r = 0.581 and P = 0.00141, r = 0.574, respectively). The assessment of DCE-MRI parameters may prove to be a valuable non-invasive method for assessing tumor cell proliferation and MVD of patients with oral cancer. (C) 2008 Elsevier Ltd. All rights reserved.

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  • Analysis of magnetic resonance images of disk positions and deformities in 1,265 patients with temporomandibular disorder. 国際誌

    Yong-Suk Choi, Jun-Ichi Asaumi, Miki Hisatomi, Teruhisa Unetsubo, Yoshinobu Yanagi, Hidenobu Matsuzaki, Hironobu Konouchi, Eui-Hwan Hwang, Sang-Rae Lee

    The open dentistry journal   3   1 - 20   2009年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVES: To compare MRI manifestations according to gender and age and to identify correlations between clinical manifestations and MRI findings in patients with temporomandibular disorder (TMD) as based on a large series. MATERIALS AND METHODS: Fat suppressed oblique sagittal images of the open and closed mouth were acquired, and MRI scanning parameters were applied. RESULTS: The patients consisted of 946 females (average, 36.6 years old), and 319 males (average, 34.3 years old). In all TMD patients, 945 had symptoms in the unilateral temporomandibular joint (TMJ) and 320 in the bilateral TMJ. There were significant differences in the distribution of disk positions based on age, regardless of gender, in the unilaterally and bilaterally symptomatic groups; however, the results were not significant in the asymptomatic group. There were significant differences with respect to the distribution of disk positions between males and females in asymptomatic group and in the unilaterally symptomatic group, although the bilaterally symptomatic group did not show significant differences in this regard. As regards the disk positions in the joints of the three groups (asymptomatic group, unilaterally and bilaterally symptomatic groups), there were significant interactive effects of disk positions, regardless of gender. There were statistically significant age-related differences in disk deformities in all symptom groups, regardless of gender, except for in the group of males lacking symptoms in either joint. As regards disk deformities among the three groups studies here, there were significant interactive effects for disk positions, regardless of gender.

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  • 岡山大学歯学部の口腔領域悪性腫瘍患者におけるFDG-PET検査の有用性に関する検討

    久富 美紀, 此内 浩信, 柳 文修, 松崎 秀信, 畦坪 輝寿, 繁原 宏, 加地 充昌, 金澤 右, 浅海 淳一

    岡山歯学会雑誌   27 ( 2 )   99 - 103   2008年12月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    2006年4月〜2008年9月にPET撮影を行った頭頸部悪性腫瘍患者121名173例(男68名、女53名、年齢29〜89歳)を対象に検討した。半年毎の患者数は22例、32例、42例、38例、39例と推移し、術後の割合が36.4%、46.9%、57.1%、60.5%、64.1%と増加傾向を示した。原発巣は術前78例中73例(93.6%)にFDGの異常集積を認め、偽陰性5例は4例が上皮内癌からT1の表在性の悪性腫瘍で、1例が高血糖であった。術後94例中16例(17.0%)に異常集積を認め、表在性の悪性腫瘍1例は偽陰性であった。リンパ節は術前初発症例78例中24例(30.8%)、術後では94例中19例(20.2%)に異常集積を認め、偽陰性3例(1.7%)は高血糖1例、内部壊死を起こした2例であった。遠隔転移は7例で、2例は胸部CTで既に疑われており、5例はPET検査で認識でき、重複癌である多臓器原発の悪性腫瘍2例、原発性肺癌2例を認めた。以上より原発巣、所属リンパ節転移、遠位転移、重複癌の検出にPETの有用性が示されたが偽陰性も少なからずあることから、他のモダリティとの組み合わせにより診断能を向上させることが必要と考えた。

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  • Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors 国際誌

    Miki Hisatomi, Jun-Ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Yuu Maki, Jun Murakami, Hidenobu Matsuzaki, Yasutoshi Honda, Hironobu Konouchi

    ORAL ONCOLOGY   43 ( 9 )   940 - 947   2007年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CImax300 or CImax6003 which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and T-max, which was the time that corresponded to the CImax300. Washout ratio (WR300 or WR600) was defined as follows: CImax300 - CI300s/CImax300 or CImax600 - CI600s/CImax600 X 100 (%), where CI300 or CI600 was the CI at 300 s or 600 s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three Cl curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 < 10%, Warthin tumor; Tmax < 60 s and WR300 > 40%, and malignant tumor; 60 s < Tmax < 210 s and 10% < WR300 < 30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR. (c) 2006 Elsevier Ltd. All rights reserved.

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  • Novel cell-surface peptides specific to human oral squamous cell carcinoma using an E-coli peptide display library 国際誌

    Noriko Kawai, Junichi Asaumi, Jun Murakami, Toru Wakasa, Masahiro Kuroda, Miki Hisatomi, Teruhisa Unetsubo, Yuu Maki, Hidenobu Matsuzaki, Yoshinonu Yanagi, Hironobu Konouchi

    ONCOLOGY REPORTS   17 ( 4 )   787 - 791   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPANDIDOS PUBL LTD  

    We attempted to find a specific antigen of oral squamous cell carcinoma (SCC) cells that could be safely applied to gene therapy in the conservative clinical treatment of oral cancer. We performed subtraction using normal human keratinocyte cells, followed by selection using four oral SCC cell lines. We isolated three clones from poorly differentiated SCC cells and four from well-differentiated SCC cells. These seven clones adsorbed to the oral SCC cells at rates 10-100 times those of normal human keratinocyte cells. The three clones from the poorly differentiated SCC cells showed the same peptide sequence (LAPRTHP). Of the four clones from the well-differentiated SCC cells, three showed the same peptide sequence (FGTLPGT) and the fourth showed a different one (VTPNSTP). Each peptide sequence may recognize the material that exists specifically on the oral SCC cell cortex. We can expect applications not only for tumor-targeting treatment using a gene therapy virus vector but also for diagnosis using, as a tumor marker, the peculiar SCC surface material that these peptides recognize.

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  • Enhancement effects of test injection with a small amount of MR contrast medium in the oral and maxillofacial region 国際誌

    Yoshinobu Yanagi, Jun-ichi Asaumi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Jun Murakami, Yuu Maki, Teruhisa Unetsubo, Kanji Kishi

    EUROPEAN JOURNAL OF RADIOLOGY   59 ( 3 )   367 - 370   2006年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Purpose: To examine whether the signal intensity of dynamic contrast-enhanced MRI (DCE-MRI) is altered by test injection of 1 ml of contrast medium, and if so, whether this change affects the DCE-MRI analysis.Materials and methods: Six healthy volunteers were examined by DCE-MRI using a Magnevist syringe and/or an Omniscan syringe for the injection of contrast medium. Each scan was performed 10 times using steady-state free precession (3D-FISP), a sequence for DCE-MRI, before and after intravenous injection of 1 ml of the contrast medium. The internal pterygoid muscle, masseter muscle, tongue, parotid gland, submandibular gland, bone marrow of the mandible, subcutaneous adipose tissue, and common carotid artery were determined to be regions of interest (ROI), and the ROI internal average signal intensity was measured. The 10 data sets obtained before or after contrast medium administration for each ROI were evaluated using the paired t-test.Results: The test injection increased the signal intensities of six of eight ROIs, with all 20 experiments in the submandibular gland showing significant differences. There was no significant difference in the two ROIs corresponding to the carotid artery and subcutaneous adipose tissue of the cheek.Conclusions: The enhanced signal intensity in the tissue might have been caused by the small amount of contrast medium in the test injection. To eliminate this discrepancy caused by the test injection, a pre-contrast scan should be performed when the average signal intensity of an ROI is measured. We therefore believe that the data obtained before a test injection may be important in the analysis of DCE-MRI. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

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  • Usefulness of contrast enhanced-MRI in the diagnosis of unicystic ameloblastoma 国際誌

    Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Noriko Kawai, Hidenobu Matsuzaki, Kanji Kishi

    ORAL ONCOLOGY   42 ( 5 )   481 - 486   2006年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The radiographic features of unicystic ameloblastoma (UA) are typically unilocular and round area of radiolucency. Therefore, this type of lesion is often misdiagnosed as an odontogenic keratocyst or a dentigerous cyst. UA should be differentiated from odontogenic cysts because the former have a higher rate of recurrence than the latter. In the present study, we performed contrast enhanced-MRI (CE-MRI) to diagnose 13 cases of unilocular, round radiolucent lesions visualized on panoramic radiograph and/or CT. In the cases of UA, low signal intensity was observed on T1-weighted images (WIs), and a markedly high signal intensity was observed on T2-WIs; moreover, relatively thick rim-enhancement with/without small intraluminal nodules was observed upon CE-T1 WIs. CE-MRI was considered useful in the diagnosis of UA, as characteristic features of this type of Lesion i.e., thick enhancement of the tumor wall and small intraluminal nodules were detected only by CE-MRI in the present study. (c) 2005 Elsevier Ltd. All rights reserved.

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  • 好酸球肉芽腫の臨床的・X線学的検討

    浅海 淳一, 畦坪 輝寿, 牧 優, 村上 純, 松崎 秀信, 久富 美紀, 河井 紀子, 柳 文修, 此内 浩信, 岸 幹二

    岡山歯学会雑誌   24 ( 2 )   37 - 41   2005年12月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    病理組織学的に好酸球肉芽腫と診断した4例を対象とした.主訴は4例中2例が腫脹,1例が疼痛,1例がX線撮影時に偶然発見されたものであった.臨床的・X線学的に4例中2例は悪性腫瘍,1例は骨髄炎と診断され,1例は不明であった.最終的には病理組織学的に全例,好酸球肉芽腫と診断した.X線学的には,顎骨内に生じた14病巣はび漫性のX線透過像を示した.処置は8病巣で掻爬あるいは辺縁骨切除などの外科処置,4病巣で放射線照射,3病巣で化学療法,2病巣で外科処置と放射線照射,3病巣で放射線照射と化学療法を行った.いずれの処置に対してもよく反応したが,化学療法に関しては悪性リンパ腫の診断の基に行ったもので,反応は悪かった.外科処置のみを行った4病巣に再発を生じたが,放射線照射および外科処置と放射線照射の併用によって制御された

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  • Assessment of ameloblastomas using MRI and dynamic contrast-enhanced MRI. 国際誌

    Jun-ichi Asaumi, Miki Hisatomi, Yoshinobu Yanagi, Hidenobu Matsuzaki, Yong Suk Choi, Noriko Kawai, Hironobu Konouchi, Kanji Kishi

    European journal of radiology   56 ( 1 )   25 - 30   2005年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We retrospectively evaluated magnetic resonance images (MRI) and dynamic contrast-enhanced MRI (DCE-MRI) of ameloblastomas. MRI and DCE-MRI were performed for 10 ameloblastomas. We obtained the following results from the MRI and DCE-MRI. (a) Ameloblastomas can be divided into solid and cystic portions on the basis of MR signal intensities. (b) Ameloblastomas show a predilection for intermediate signal intensity on T1WI, high signal intensity on T2WI, and well enhancement in the solid portion; they also show a homogeneous intermediate signal intensity on T1WI and homogeneous high signal intensity on T2WI, and no enhancement in the cystic portion. (c) The mural nodule or thick wall can be detected in ameloblastomas lesions. (d) CI curves of ameloblastomas show two patterns: the first pattern increases, reaches a plateau at 100-300 s, then sustains the plateau or decreases gradually to 600-900 s, while the other increases relatively rapidly, reaches a plateau at 90-120 s, then decreases relatively rapidly to 300 s, and decreases gradually thereafter. There was no difference in the CI curve patterns among primary and recurrent cases, a case with glandular odontogenic tumor in ameloblastoma or among histopathological types such as plexiform, follicular, mixed, desmoplastic, and unicystic type.

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  • Assessment of MRI and dynamic contrast-enhanced MRI in the differential diagnosis of adenomatoid odontogenic tumor. 国際誌

    Jun-ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Hiroshi Shigehara, Kanji Kishi

    European journal of radiology   51 ( 3 )   252 - 6   2004年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The radiographical differentiation of adenomatoid odontogenic tumor (AOT) from dentigerous cysts, calcifying odontogenic cysts, calcifying epithelial odontogenic tumors, odontogenic keratocysts and amelobastomas is sometimes difficult. We attempted to differentiate AOT from other lesions similar to AOT in radiographic findings using MRI. The MRI features of AOT in our three cases included homogeneous low SI in the cystic portion and homogeneous intermediate SI in the solid portion on T1WI, homogeneous high SI in the cystic portion and intermediate to slightly high SI in the solid portion on T2WI and enhancement of only the solid portion on CE-T1WI although none of the sequences included SI of calcifications. The contrast index curves in the three cases of AOT showed a gradual increase to 300 s, which signified a benign tumor. These MRI features were characteristic features of AOT and might be a basis for differentiating AOT from the above possible lesions in radiographic examinations.

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  • Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck. 国際誌

    Jun-Ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Kanji Kishi

    Oral oncology   40 ( 6 )   579 - 84   2004年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p = 0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p < 0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.

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  • The value of dynamic contrast-enhanced MRI in diagnosis of malignant lymphoma of the head and neck. 国際誌

    Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Kanji Kishi

    European journal of radiology   48 ( 2 )   183 - 7   2003年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In this study, we attempted to diagnose malignant lymphoma on the basis of magnetic resonance imagings (MRIs) and dynamic contrast-enhanced MRI (DCE-MRI). Eighteen lesions (in eight patients), all of which had been proven histopathologically, were detected on MRI. The eight patients included five patients with diffuse large B-cell lymphoma, one with B-cell low-grade MALT lymphoma, one with follicular lymphoma, and one with Hodgkin's lymphoma. Nine lesions were located in the submandibular region, three in the buccal region, two in the orbit region, two in the submental region, and one each in the palatal and tonsil regions. The diameter of the lesions ranged between 9 and 42.2 mm (average: 22.4 mm). The signal intensities (SIs) of the 18 lesions were examined on T1-weighted (T1WI), T2WI, and gadopentetate (Gd)-T1WI. One lesion in case 8 was excluded from DCE-MRI findings, i.e., the regions of interest could not be adequately set on DCE-MRIs. The contrast index (CI) curves of the remaining 17 lesions were prepared. All 18 lesions showed almost the same images on T1WI, T2WI, and Gd-T1WI, although they represented four types of lymphoma. The images showed homogeneous SI that was intermediate to slightly high SI on T1WI, slightly high SI on T2WI, and moderately enhanced on Gd-T1WI. Thus, the cases of malignant lymphoma in this study showed relatively characteristic features based on MRI; however, these features might be non-specific. The CI curves in this study showed a relatively rapid increase, reaching a maximum CI at 45-120 s, and a relatively rapid decrease in most lesions (14/17; 82.4%); on the other hand, the curves of 3 of the 15 lesions (17.6%) showed relatively rapid increase, sustenance of a plateau, and a gradual decrease thereafter. These patterns of CI curves may indicate characteristic features useful for distinguishing malignant lymphomas from other lesions.

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  • Usefulness of dynamic contrast-enhanced MRI in the differential diagnosis of angioleiomyoma in the buccal space 査読

    Yoshinobu Yanagi, Jun-ichi Asaumi, Miki Hisatomi, Hidenobu Matsuzaki, Yosutoshi Honda, Hironobu Konouchi, Kanji Kishi

    European Journal of Radiology Extra   48 ( 1 )   14 - 18   2003年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/s1571-4675(03)00080-4

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  • Assessment of pleomorphic adenomas using MRI and dynamic contrast enhanced MRI. 国際誌

    Miki Hisatomi, Jun-ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Hidenobu Matsuzaki, Yasutoshi Honda, Kanji Kishi

    Oral oncology   39 ( 6 )   574 - 9   2003年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a). Pleomorphic adenomas showed a predilection for homogeneous intermediate signal intensity on T1-weighted images (T1WI), heterogeneous high signal intensity on T2-weighted images, and heterogeneous enhancement on Gd-T1WI. (b). Of 11 contrast index (CI) curves of pleomorphic adenomas, nine CI curves (81.8%) increased gradually to 600 s or increased gradually, reached a plateau, and sustained the plateau to 600 s. The remaining two (18.2%) increased gradually and decreased gradually thereafter. (c). CI curves reached the maximum CI index at 135-300 s.

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  • Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis. 国際誌

    Yoshinobu Yanagi, Jun-ichi Asaumi, Yuu Maki, Jun Murakami, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Yosutoshi Honda, Kanji Kishi

    European journal of radiology   47 ( 1 )   6 - 9   2003年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice.

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  • Evaluation of tumor proliferation using dynamic contrast enhanced-MRI of oral cavity and oropharyngeal squamous cell carcinoma. 国際誌

    Hironobu Konouchi, Jun ichi Asaumi, Yoshinobu Yanagi, Hiroshi Shigehara, Miki Hisatomi, Hidenobu Matsuzaki, Kanji Kishi

    Oral oncology   39 ( 3 )   290 - 5   2003年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We investigated the relationship between the enhanced patterns acquired by dynamic MRI and the tumor cell proliferation estimated by immunostaining proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (SCC). Thirty patients with primary oral SCC underwent dynamic contrast enhanced (DCE)-MRI using a three-dimensional fast imaging with steady-state precession sequence. Tumor cell proliferation of all surgical specimens was evaluated using immunohistochemical staining with the anti-PCNA antibody. The relationship between the dynamic MRI parameters (maximum CI and maximum CI gain) and the PCNA labeling index was statistically analyzed using regression analysis. The time contrast index curves of all cases showed a rapid and high uptake pattern. The PCNA labeling index showed a significant correlation with maximum CI and maximum CI gain (P<0.0001, r=0.866 and P=0.0019, r=0.544, respectively). The assessment of DCE-MRI parameters may provide valuable information for tumor cell proliferation of the patients with oral cancer.

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  • Effects of p53 gene therapy in radiotherapy or thermotherapy of human head and neck squamous cell carcinoma cell lines. 査読

    Yuzuru Higuchi, Jun-ichi Asaumi, Jun Murakami, Hidenobu Matsuzaki, Toru Wakasa, Tetsuyoshi Inoue, Hiroshi Shigehara, Hironobu Konouchi, Miki Hisatomi, Shoji Kawasaki, Yoshio Hiraki, Kanji Kishi

    Oncology Reports   10 ( 3 )   671 - 677   2003年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines 査読

    Yuzuru Higuchi, Jun-ichi Asaumi, Jun Murakami, Hidenobu Matsuzaki, Toru Wakasa, Tetsuyoshi Inoue, Hironobu Konoucni, Miki Hisatomi, Yoshinobu Yanagi, Yasutoshi Honda, Hiroshi Shigehara, Kanji Kishi

    Oncology Reports   10 ( 2 )   415 - 420   2003年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • MR features of aneurysmal bone cyst of the mandible and characteristics distinguishing it from other lesions. 国際誌

    Jun-ichi Asaumi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Hiroshi Shigehara, Yasutoshi Honda, Kanji Kishi

    European journal of radiology   45 ( 2 )   108 - 12   2003年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aneurysmal bone cyst (ABC) is a relatively rare, non-neoplastic expansile lesion of bone. Bleeding may occur during an operation or biopsy for ABC, as this cyst is an aneurys with numerous pools of blood. Therefore, it is necessary to diagnose ABC before treatment or biopsy. In the present report, we describe the characteristic computed tomography (CT) and magnetic resonance imaging (MRI) features of ABC in the mandible. Based on the literature and on our own experiences, we compare with the features of ABC with the corresponding features of other lesions showing similar conventional radiographic appearances. In the present case, bone-targeting CT showed the characteristic feature, which reflected the histopathological appearance of a partially cystic meshwork divided by coarse septa. MRI showed almost homogeneous intermediate signal intensity, including a partial slight low-signal-intensity area on the T1-weighted image, and homogeneous high signal intensity, which showed a 'bubbly' appearance, on T2-weighted image. On the enhanced T1-weighted image, the intermediate signal intensity areas apart from the areas that showed slight low-signal intensity on the non-enhanced T1-weighted image, were well enhanced. This creates a 'honeycomb' appearance. The 'meshwork' appearance on bone-targeting CT, the 'bubbly' appearance on the T2WI and the 'honeycomb' appearance on Gd-T1WI may be the characteristic features of ABC.

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  • Thermoradiotherapy combined with p53 gene therapy of human salivary gland adenocarcinoma cell line 査読

    Jun-Ichi Asaumi, Yuzuru Higuchi, Jun Murakami, Hidenobu Matsuzaki, Toru Wakasa, Tetsuyoshi Inoue, Hiroshi Shigehara, Hironobu Konouchi, Miki Hisatomi, Shoji Kawasaki, Masahiro Kuroda, Yoshio Hiraki, Kanji Kishi

    Oncology Reports   10 ( 1 )   71 - 74   2003年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Assessment of carcinoma in the sublingual region based on magnetic resonance imaging 査読

    Jun-Ichi Asaumi, Hiroshi Shigehara, Hironobu Konouchi, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Kanji Kishi

    Oncology Reports   9 ( 6 )   1283 - 1287   2002年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Spandidos Publications  

    DOI: 10.3892/or.9.6.1283

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  • Thermoradiotherapy in human head and neck squamous cell carcinoma cell lines. 国際誌

    Jun-Ichi Asaumi, Yuzuru Higuchi, Jun Murakami, Masahiro Kuroda, Koichi Shibuya, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Hiroshi Shigehara, Shoji Kawasaki, Kanji Kishi, Yoshio Hiraki

    International journal of molecular medicine   10 ( 3 )   287 - 91   2002年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Thermoradiosensitivity of 8 cell lines of head and neck squamous cell carcinoma (HO-1-u-1, HSC2, HSC3, HSC4, SAS, KB, Hep2, and Ca9-22) was investigated. The differences of radiosensitivity between the cell line with the highest radiosensitivity and the cell line with the lowest radiosensitivity were 1.7-, 7.7-, and 41-fold at 2, 6 and 8 Gy, respectively. The differences between the cell line with the highest thermosensitivity and the cell line with the lowest thermosensitivity were 2.4-, 6.2- and 34.4-fold at 43 degrees C for 40, 60 and 100 min, and 2.6-, 4.9- and 127-fold at 44 degrees C for 20, 30 and 50 min, respectively. These findings indicated that there were large differences in both radiosensitivity and thermosensitivity among the 8 cell lines. There was a negative relationship between radiosensitivity and thermosensitivity (43 degrees C: r=-0.600, 44 degrees C: r=-0.848) in 7 of 8 cell lines, the exception being the HSC4 cell line, which was resistant to both therapies. Four of the 8 cell lines at 43 degrees C and 5 at 44 degrees C in the radiotherapy combined with thermotherapy showed actual survival rates smaller than the theoretical survival rates. Thus, thermoradiotherapy was deemed effective in the head and neck carcinoma cell lines, although 1 of 8 cell lines was resistant to both radiotherapy and thermotherapy.

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  • Application of dynamic MRI to differentiating odontogenic myxomas from ameloblastomas. 国際誌

    Jun-ichi Asaumi, Hidenobu Matsuzaki, Miki Hisatomi, Hironobu Konouchi, Hiroshi Shigehara, Kanji Kishi

    European journal of radiology   43 ( 1 )   37 - 41   2002年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is often difficult to radiographically distinguish odontogenic myxomas from ameloblastomas. In the present study, we tried to differentiate odontogenic myxomas from ameloblastomas using dynamic magnetic resonance imaging (dynamic MRI). Two cases of ameloblastoma with cystic components and two cases of odontogenic myxoma were compared by dynamic MRI. The dynamic MRI features of solid areas of ameloblastomas showed a rapid enhancement, reaching maximum contrast at 45-60 s, and maintained these enhancement levels or showed a gradual wash-out to 600 s thereafter; in contrast, those of the cystic areas of ameloblastomas showed no enhancement. The dynamic MRI features of the whole area of odontogenic myxomas (we considered the whole area to be the tumor substance in the odontogenic myxomas, as based on histopathological examinations) showed a gradual increase in enhancement at 500-600 s. The central portions of the odontogenic myxomas, which did not appear to be enhanced on Gd-T1 weighted images also showed a gradual increase in enhancement at 500-600 s, though the increase was minimal. These results indicate that the dynamic MRI features of odontogenic myxomas are different from those of ameloblastomas. Therefore, dynamic MRI may be a useful tool for diagnosis of myxoma.

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  • Assessment of dynamic MRI of Warthin's tumors arising as multiple lesions in the parotid glands. 国際誌

    Miki Hisatomi, Jun-ichi Asaumi, Hironobu Konouchi, Yoshinobu Yanagi, Hidenobu Matsuzaki, Kanji Kishi

    Oral oncology   38 ( 4 )   369 - 72   2002年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We examined three patients with multiple synchronous Warthin's tumors in the bilateral parotid and described the value of using dynamic MRI. The time course of the contrast index (CI curves) was calculated from a dynamic series. Warthin's tumors showed intermediate signal intensity on T1WI, heterogeneous high and intermediate signal intensity on T2WI and a slight enhancement on Gd-T1WI. Warthin's tumors of CI curves showed specific findings. CI curves in each lesion showed the same pattern. It was difficult to diagnose masses as Warthin's tumors using only MR images on T1, T2 and Gd-T1WI. Dynamic MRI can distinguish Warthin's tumors from other possible tumors except for oncocytoma. Therefore, the use of dynamic MRI is recommended as a diagnostic method for Warthin's tumors in multiple synchronous lesions of the parotid gland.

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  • Two cases of polyostotic eosinophilic granuloma 査読

    Asaumi J, Konouchi H, Hisatomi M, Matsuzaki H, Kishi K

    Dento Maxillo Facial Radiology   29 ( 6 )   382 - 385   2000年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 第三大臼歯の萠出に関するX線学的検討

    樋口 譲, 浅海 淳一, 繁原 宏, 此内 浩信, 松崎 秀信, 岸 幹二

    岡山歯学会雑誌   19 ( 1 )   155 - 159   2000年6月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    上顎は,歯胚形成が進むにしたがって萠出角度は垂直方向となる傾向にあった.下顎は,歯胚形成が歯冠に限局した時期に既に近心傾斜する傾向にあり,歯根3分の1以上形成された段階以降に近心に46度以上傾斜している症例は更に傾斜する

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  • 単純性骨嚢胞の臨床X線学的検討

    松崎 秀信, 相賀 秀樹, 浅海 淳一, 若狭 亨, 岸 幹二

    岡山歯学会雑誌   18 ( 2 )   339 - 346   1999年12月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    1)本病変は全て下顎に発症し,平均年齢は22.0歳であった. 2)X線写真上の特徴は,弱い辺縁を持つX線透過像を示し,頬舌的な膨隆は1例のみで認められた. 3)上方部辺縁が歯根に接する12症例中10例では,いわゆる"帆立貝状"を呈しており,下方辺縁が下顎骨下縁に達する3例では皮質骨の菲薄化が認められた. 4)生検のみを施行した3例も外科処置を施行した10例と同様に治癒傾向を示し再発を認めなかった.したがって,単純性骨嚢胞の処置は生検により確定診断を得た後に経過観察を行うことが有用な方法であると考えられた

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  • 腎性骨異栄養症のX線学的検討

    相賀 秀樹, 松崎 秀信, 浅海 淳一, 若狭 亨, 岸 幹二, 竹林 俊明, 松村 智弘

    岡山歯学会雑誌   18 ( 2 )   347 - 353   1999年12月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    自験例では全ての症例にCa,Pの代謝異常に起因する腎性骨異栄養症を反映した歯周組織及び顎骨の様々な特徴的なX線像上の変化を認めた.したがって,歯科臨床上,患者の病歴,他疾患併発の可能性に留意すると共に本症発現に伴うX線写真上の顎骨変化も十分認識しておく必要がある

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  • 顎関節におけるSynovial Osteochondromatosisの画像所見について

    若狭 亨, 繁原 宏, 松崎 秀信, 相賀 秀樹, 岸 幹二

    岡山歯学会雑誌   18 ( 1 )   259 - 269   1999年6月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

    Synovial osteochondromatosisが疑われた6例及び病理組織学的に確定した2例について全例でX線撮影,8例中4例でCT検査,8例中3例でMRI検査を行った.X線所見では全例で遊離体がみられ,関節腔の拡大は3例,運動制限は5例,関節表面の不整や骨硬化像は各5例に認められた.CT所見では4例中2例でerosionと骨硬化像,1例でerosionのみ,1例で骨硬化像のみが認められ,全4例で翼突筋の圧迫偏位像を認めた.MRI所見では3例中2例においてT2強調像で翼突筋の信号が高くなり,1例では筋の信号の亢進はなかった.又,遊離体は3例共T1強調像で低信号を示したが,T2強調像では2例が高信号,1例が低信号であった

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書籍等出版物

  • Perfusion Imaging in Clinical Practice: A Multimodality Approach to Tissue Perfusion Analysis First Edition

    Farhood Saremi( 担当: 分担執筆 ,  範囲: Perfusion Imaging in Maxillofacial Lesions)

    Lippincott Williams & Wilkins  2015年7月 

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  • Oral Cancer: Symptoms, Management and Risk Factors

    Sheng-Po Hao( 担当: 分担執筆 ,  範囲: Brachytherapy for Oral Cancer)

    Nova Science Publishers  2013年12月 

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  • Cysts: Causes, Diagnosis and Treatment Options

    Arturo Mendes Ortiz, Augusto Jimenez Moreno( 担当: 分担執筆 ,  範囲: Recent Advances in the diagnostic imaging of cysts and pseudocysts in the oral and maxillofacial region)

    Nova Science Publishers  2012年4月 

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  • Oral Cancer : Causes, Diagnosis and Treatment

    Michael K. Harris( 担当: 分担執筆 ,  範囲: Radiotherapy for Oral Cancer)

    Nova Science Publishers  2011年11月 

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MISC

  • 口腔がんに対する放射線療法における歯科医師の役割

    松崎 秀信, 浅海 淳一

    岡山歯学会雑誌   29 ( 1 )   15 - 23   2010年6月

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    記述言語:日本語   出版者・発行元:岡山歯学会  

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講演・口頭発表等

  • 放射線性う蝕の抑制に関する検討

    松﨑 久美子, 小野 瀬里奈, 藤代 万由, 佐々木 禎子, 梶谷 明子, 松﨑 秀信, 丸山 貴之, 横井 彩, 木股 敬裕, 吉山 昌宏

    日本がん口腔支持療法学会第6回学術大会  2020年12月5日 

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    開催年月日: 2020年12月5日 - 2020年12月6日

    会議種別:口頭発表(一般)  

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  • 歯科テクニックを使用した高線量率RALSによるモールド法での口唇癌の治療

    松﨑 秀信, 宮崎 文伸, 青山 英樹, 渡邉 謙太, 松﨑 久美子, 武田 斉子, 勝井 邦彰, 吉山 昌宏, 浅海 淳一, 木股 敬裕

    日本がん口腔支持療法学会第6回学術大会  2020年12月5日 

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    開催年月日: 2020年12月5日 - 2020年12月6日

    会議種別:ポスター発表  

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  • 3Dプリンターを使用した放射線治療用マウスピースの試作

    松﨑 秀信, 宮崎 文伸, 松﨑 久美子, 青山 英樹, 竹内 哲男, 上田 明広, 勝井 邦彰, 吉山 昌宏, 浅海 淳一

    日本がん口腔支持療法学会第5回学術大会  2019年12月1日 

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    開催年月日: 2019年11月30日 - 2019年12月1日

    会議種別:ポスター発表  

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  • 脳腫瘍の強度変調放射線治療におけるマウスピースの有用性に関する検討

    松﨑 秀信, 青山 英樹, 宮崎 文伸, 松﨑 久美子, 田平 亮, 渡邉 謙太, 片山 敬久, 勝井 邦彰, 吉山 昌宏, 浅海 淳一

    日本がん口腔支持療法学会第5回学術大会  2019年11月30日 

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    開催年月日: 2019年11月30日 - 2019年12月1日

    会議種別:口頭発表(一般)  

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  • 岡山大学病院における放射線治療支援への取り組み

    宮崎 文伸, 松崎 秀信, 松崎 久美子, 青山 英樹, 宇野 弘文, 竹内 哲男, 上田 明広, 太田 圭二, 浅海 淳一, 窪木 拓男

    第21回日本口腔顎顔面技工学会学術大会  2019年11月16日 

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    開催年月日: 2019年11月16日

    会議種別:口頭発表(一般)  

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  • 脳腫瘍の外部放射線治療における歯科技工物を用いた患者位置精度管理の評価

    田平 亮, 青山 英樹, 松崎 秀信, 宮崎 文伸, 大塚 裕太, 河合 佑太, 香川 芳徳, 田原 誠司, 宇野 弘文, 本田 貢

    第35回日本診療放射線技師学術大会  2019年9月15日 

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    開催年月日: 2019年9月14日 - 2019年9月16日

    会議種別:口頭発表(一般)  

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  • 放射線性う蝕に対するう蝕進行抑制含嗽液の開発 招待

    松崎 久美子, 松崎 秀信, 勝井 邦彰, 久保 和子, 假谷 伸, 木股 敬裕, 吉山 昌宏

    第35回「歯科医学を中心とした総合的な研究を推進する集い (令和元年度)」  2019年8月28日 

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    開催年月日: 2019年8月28日

    会議種別:ポスター発表  

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  • 頭頸部癌患者における強度変調放射線治療中の体重減少に関する検討

    松崎 秀信, 勝井 邦彰, 松崎 久美子, 長本 幸子, 高原 陽子, 梶清 友美, 久保 和子, 水川 展吉, 假谷 伸, 木股 敬裕

    第42回日本頭頸部癌学会総会  2019年6月13日 

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    開催年月日: 2019年6月13日 - 2019年6月14日

    会議種別:ポスター発表  

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共同研究・競争的資金等の研究

  • 放射線性う蝕予防の新規アプローチ~歯面塗布型放射線防護剤の開発~

    研究課題/領域番号:21K07596  2021年04月 - 2024年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    松崎 秀信, 松崎 久美子, 青山 英樹, 吉尾 浩太郎

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

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  • 放射線う蝕の治療法の確立に向けたセルフエッチング接着システムの基礎的研究

    研究課題/領域番号:19K10149  2019年04月 - 2023年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    松崎 久美子, 吉山 昌宏, 島田 康史, 松崎 秀信

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    頭頸部癌に対する放射線治療の晩期障害のひとつに、放射線う蝕が挙げられる。フッ化物塗布によるう蝕予防効果には限界があり、放射線う蝕は一度発症すると急速かつ多発的に進行する。そのため、応急的にう蝕進行抑制剤を塗布し、日を改めて接着システムを使用したコンポジットレジン修復を行うことが多い。しかし、う蝕進行抑制剤は、被着面である象牙質表面のコラーゲンを凝固させるため、接着システムのプライマーが充分に浸透しない可能性がある。その上、接着システムの研究は、通常、口腔内が湿潤であることを前提として検証される。しかし、われわれが行った疫学調査で、頭頸部癌放射線治療後の唾液は、正常値の約1/3の量で泡状、粘性であった。そこで、口腔内環境に適応した基礎研究が必要と考えた。
    本研究の計画では、①う蝕進行抑制剤塗布後の象牙質における脱灰抑制効果の検証、②異なる保管環境における接着試料体の接着性の検討、③研究Ⅱの接着性の向上に関する研究、の大きく3つの骨子で成り立っている。
    2019~2020年にかけて、①う蝕進行抑制剤塗布後の象牙質における脱灰抑制効果の検証を行う計画を立てていた。現在までに、亜鉛含有/非含有象牙質知覚過敏抑制剤による象牙質の脱灰抑制効果を、波長走査型光干渉断層計(SS-OCT)を用いて検証した。その結果、亜鉛含有の材料は、象牙質表面よりやや深い位置で脱灰抑制効果を発揮し、亜鉛非含有の材料は、象牙質表面で脱灰抑制効果を発揮する可能性が示された。また、市販の象牙質知覚過敏抑制剤に、4段階に濃度を変えた塩化ストロンチウムを配合したものを試作し、象牙質の脱灰抑制効果を検討している。

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  • 3Dプリンターを用いた放射線治療用デバイス作製システムの開発に関する検討

    研究課題/領域番号:16K11502  2016年04月 - 2020年03月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    松崎 秀信, 勝井 邦彰, 松崎 久美子, 青山 英樹

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    配分額:4680000円 ( 直接経費:3600000円 、 間接経費:1080000円 )

    頭頸部癌に対する強度変調放射線治療における、オーダーメイドマウスピース型デバイスの有用性について検討を行った。また、3Dプリンターで作製するマウスピース型デバイスの試作を行った。結果として、オーダーメイドタイプは、強度変調放射線治療時の位置誤差の低減に有用であった。また、光学印象採得のデータを使用して3Dプリンターで作製したデバイスの適合は、オーダーメイドタイプと比べ遜色がなかった。一方で、臨床で使用するためには、光学スキャナやソフトウェア、3Dプリンターの導入コストの問題、データソースとしてCT画像を使用する場合の金属アーチファクト低減処理について検討が必要である。

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  • 口腔癌における dynamic CE-MRI を用いたリンパ節転移の潜在性の評価

    研究課題/領域番号:21592572  2009年 - 2012年

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    此内 浩信, 浅海 淳一, 柳 文修, 久富 美紀, 松崎 秀信

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    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    近年癌組織において腫瘍内血管の増生とともにリンパ管が増生していることが明らかになってきた。癌の転移様式はリンパ管性といわれている。そこで、dynamic CE-MRIは腫瘍内の血流を反映した画像診断が行えるため、同検査法を用いて癌腫内のリンパ管の増生について評価できないか調査を行い、ひいては局所リンパ節転移の潜在性が評価できないか調査を行った。dynamic CE-MRI と病理標本上の腫瘍内血管数とは正の相関が示された。また、病理標本上の腫瘍内血管数とリンパ管数との間にも正の相関が認められたが、dynamic CE-MRI と、病理標本上のリンパ管数との間には相関関係が認められなかった。しかし、リンパ節転移群と非転移群の原発巣の dynamic CE- MRI の間には有意差が認められ、原発巣の dynamic CE- MRI をもちいたリンパ節転移の潜在性が評価可能であることが示唆された

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  • テーラーメード医療に向けたDNAエピジェネティックス定量

    研究課題/領域番号:20791516  2008年 - 2009年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    松崎 秀信

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    配分額:3380000円 ( 直接経費:2600000円 、 間接経費:780000円 )

    初年度はエピジェネティックスの解析及び定量手法の確立を目指した。口腔癌細胞株を7株、対象は抗癌剤感受性に関連するMGMT遺伝子(O6-methylguanine DNA methyltransferase)である。メチル化の定量的検討にはbisulfite DNAのPCR後にTAクローニングし、シーケンシグした。結果、細胞株間でのメチル化の多寡を半定量的に解析出来た。さらに、ChIP アッセイによる定量法も検討した。次年度は、抗癌剤FR901228の標的の特定を目指した。FR901228投与前後の各細胞株での血管新生関連遺伝子発現変化検討として、リアルタイムRT-PCRでの網羅的解析を行った。その結果、FR901228投与後において、matrix metallo proteinase (MMP)ならびにTissue inhibitor of metallo proteinase (TIMP)発現が低下する細胞株を数株認めた。さらに、HUVEC(血管内皮細胞)への影響を検討により、血管新生能が低下した。

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  • 口腔領域におけるダイナミックMRIに関する研究

    研究課題/領域番号:19592170  2007年 - 2009年

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    浅海 淳一, 此内 浩信, 柳 文修, 久冨 美紀, 松崎 秀信

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    配分額:4420000円 ( 直接経費:3400000円 、 間接経費:1020000円 )

    本研究では、病理組織学的に扁平上皮癌の予後因子と考えられる腫瘍増殖能や血管新生を免疫組織学的に評価した値とMRIで癌組織の血行動態を評価したダイナミックMRIから導き出したパラメーターとの間に正の相関関係があることを見出した。このことからダイナミックMRIを評価することによって、口腔扁平上皮癌の増殖能や血管新生を評価でき、ひいては非侵襲的に口腔扁平上皮癌にり患した人の予後を予測できる可能性があることを示した。

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  • 口腔内悪性腫瘍株における14-3-3sigma発現制御状況とその機構に関する研究

    研究課題/領域番号:14771134  2002年 - 2003年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    松崎 秀信

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    配分額:3900000円 ( 直接経費:3900000円 )

    前年度までに,口腔癌の放射線感受性における14-3-3σの役割を検討し,検討した口腔癌細胞株6株はすべて,放射線によるDNA障害後,G_2M期に停止するが,14-3-3σの低発現株では,同高発現株に比較してそのG_2M期の停止からより早く回復することを明らかにした。しかしながら,14-3-3σ発現と放射線感受性との関連性を示すことはできなかった。
    今年度は,14-3-3σ遺伝子に生じるメチル化を検索し,転写制御への関与につて検討を行った。
    14-3-3σ低発現株は,メチル化を多く持つとの予想に反し,低発現株3株のうち2株のみに数か所のメチル化を認めたのみであった。
    一方,14-3-3σ高発現株ではメチル化を全く認めなかった。このことは14-3-3σの転写抑制において,メチル化はあまり関与していない可能性を示唆していた。
    また,p53に変異のある14-3-3σ高発現株では放射線照射によって14-3-3σの誘導が認められたが,14-3-3σ低発現株ではp53に変異のない細胞株においてでさえ14-3-3σ誘導は少なかった。
    このことは,口腔癌においてはp53のステータスにかかわらず,14-3-3σが放射線照射によっての誘導されることを示していた。
    今回の研究により14-3-3σ発現はCpGのメチル化やp53の状態によっても影響されるもののその発現は複合的であり,さらなる研究が必要と考えられた。
    今回の,研究はまとめて英文誌に投稿中である。

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  • 顎口腔領域病変のダイナミックMRIによる質的診断能に関する研究

    研究課題/領域番号:14370603  2002年 - 2003年

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    岸 幹二, 柳 文修, 此内 浩信, 浅海 淳一, 松崎 秀信, 久富 美紀

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    配分額:12500000円 ( 直接経費:12500000円 )

    本研究は,ダイナミックMRIが,造影効果を経時的に観察することによって,腫瘍の血流動態を知ることが出来ることから,各種病変に特有の経時的造影パターンを分類することで,病変とくに腫瘍病変の良性・悪性の鑑別能を評価し,ダイナミックMRIの質的診断能について検討することであった。さらに種々の病変の性格の描出能について明らかにすることで,発現様相が不明な顎口腔領域特有の疾患についても検討を加えた。また,各種病変の経時的造影パターンの把握に加えて,ダイナミックMRI画像と同一平面の病理学的標本との比較により増殖細胞核抗原との相互の相関性を分析し,ダイナミックMRIによる非侵襲的な口腔癌の増殖能と予後判定の可能性を示した。
    顎口腔病変におけるダイナミックMRIを分析し,CI curveやパラメーターが病変特有のパターンを持ち顎口腔領域の鑑別に有用である結果を以下のように得ている。
    1.口腔扁平上皮癌におけるダイナミックMRIと各種免疫染色因子との関連を検討し,ダイナミックMRIが増殖細胞核抗原と相関していることから,腫瘍の増殖能を反映し予後因子としての役割の可能性を示した。
    2.単純性骨嚢胞の造影パターンが特異的であり,他の病変と鑑別できることを示した。
    3.多形性腺腫造影パターンを示し,他病変との比較を行うことで鑑別できる可能性を示した。
    4.舌下腺腫瘍において悪性の唾液腺腫瘍は,正常舌下腺よりも早期に造影されることを示した。また,舌下腺腫瘍の境界がダイナミックMRIの早期像により他のシークエンスに比較してより明瞭に示されることを示した。
    5.扁平上皮癌と悪性リンパ腫が造影パターンにより鑑別できる可能性を示した。
    6.他の画像診断では鑑別が困難な場合もある含歯性嚢胞と腺様歯原性腫瘍が造影パターンにより鑑別できることを示した。

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担当授業科目

  • 口腔顎顔面領域の臨床画像診断学 (2021年度) 第4学期  - 火4,火5

  • 放射線生物学と口腔顎顔面領域の放射線治療学 (2021年度) 第1学期  - 火4

  • 放射線生物学と口腔顎顔面領域の放射線治療学 (2021年度) 第1学期  - 火4

  • 歯と口腔疾患の画像診断学 (2021年度) 第3学期  - 水2,水3

  • 口腔顎顔面領域の臨床画像診断学 (2020年度) 第4学期  - 火1,火2

  • 口腔顎顔面領域の臨床画像診断学 (2020年度) 第4学期  - 火4,火5

  • 放射線生物学と口腔顎顔面領域の放射線治療学 (2020年度) 第1学期  - 火4

  • 放射線生物学と口腔顎顔面領域の放射線治療学 (2020年度) 第1学期  - 火4

  • 歯と口腔疾患の画像診断学 (2020年度) 第3学期  - 水2,水3

▼全件表示