Updated on 2025/04/02

写真a

 
TOMIOKA Yasuaki
 
Organization
Scheduled update Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link

Degree

  • 医学博士 ( 2023.9   岡山大学 )

Research Interests

  • lung transplantation

  • lung cancer

  • Single nucleotide polymorphism

  • 慢性移植肺機能不全

  • 急性拒絶反応

  • 肺移植後腎機能障害

Research Areas

  • Life Science / Respiratory surgery  / lung transplantation

Education

  • Okayama University   大学院医歯薬学総合研究科   病態制御科学

    2019.4 - 2023.9

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Research History

  • 岡山大学病院   助教

    2024.4

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  • 福山市民病院   科長

    2023.2 - 2024.3

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  • 島根大学医学部附属病院   助教

    2021.9 - 2023.1

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  • 島根大学医学部附属病院   医科医員

    2021.8

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  • 岡山大学病院   助教

    2020.4 - 2021.7

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  • 岡山大学病院   医員

    2019.4 - 2020.3

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  • 天理よろづ相談所病院

    2014.4 - 2019.3

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  • 石巻赤十字病院

    2012.4 - 2014.3

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Professional Memberships

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Papers

  • Novel pulmonary abdominal normothermic regional perfusion circuit for simultaneous in-donor evaluation and preservation of lungs and abdominal organs in donation after circulatory death.

    Shin Tanaka, Masashi Umeda, Hiroyuki Ujike, Tsuyoshi Ryuko, Yasuaki Tomioka, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    General thoracic and cardiovascular surgery   2025.3

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    OBJECTIVE: To overcome limitations of traditional ex vivo lung perfusion (EVLP) for controlled donation after circulatory death (cDCD) lungs, this study aimed to evaluate a novel pulmonary abdominal normothermic regional perfusion (PANRP) technique, which we uniquely designed, for in situ assessment of lungs from cDCD donors. METHODS: We modified the abdominal normothermic regional perfusion circuit for simultaneous lung and abdominal organ assessment using independent extracorporeal membrane oxygenation components. Blood was oxygenated via a membrane oxygenator and returned to the body, with pulmonary flow adjusted to maintain pressure < 25 mmHg. Femoral cannulation was performed, and the lungs were ventilated with standard settings. Organ function was assessed over 2 h using PaO2/FiO2, AST, ALT, BUN, and Cr measurements to monitor perfusion and oxygen delivery. RESULTS: PANRP maintained stable lung function, with P/F ratios above 300, and preserved abdominal organ parameters, including stable AST, ALT, BUN, and Cr levels. Adequate urine output was observed, indicating normal renal function. Pulmonary artery pressure remained < 20 mmHg, and pulmonary vascular resistance was kept at 400 dyn・s/cm5, showing no signs of lung dysfunction or injury throughout the circuit. CONCLUSIONS: PANRP offers a promising alternative to traditional EVLP for cDCD lung evaluation, allowing in situ assessment of multiple organs simultaneously. This approach may overcome logistical and economic challenges associated with ex vivo techniques, enabling a more efficient evaluation process. Further studies are warranted to confirm its clinical applicability and impact on long-term outcomes.

    DOI: 10.1007/s11748-025-02137-y

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  • Nightmare case of repeated hemorrhagic pancreatitis due to pancreatic head cancer in the acute stage after two-stage lung transplantation

    Tatsuya Hayashi, Shin Tanaka, Tsuyoshi Ryuko, Yasuaki Tomioka, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    JHLT Open   100245 - 100245   2025.3

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.jhlto.2025.100245

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  • Prognostic Analysis of Pathological Stage I Lung Adenocarcinoma Harboring Major EGFR Mutations. International journal

    Shinkichi Takamori, Makoto Endo, Akira Hamada, Shuta Ohara, Shota Fukuda, Yasuaki Tomioka, Satoshi Takamori, Atsushi Osoegawa, Kotaro Nomura, Kosuke Fujino, Mao Yoshikawa, Ken Suzawa, Kazuhiko Shien, Kenichi Suda, Fumihiko Kinoshita, Kazuki Hayasaka, Hirotsugu Notsuda, Taichi Nagano, Kyoto Matsudo, Asato Hashinokuchi, Taichi Matsubara, Shinya Katsumata, Satoshi Shiono, Junichi Soh, Yasuhisa Ohde, Mototsugu Shimokawa

    Clinical lung cancer   2024.12

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    BACKGROUND: While Epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma (LUAD) has favorable outcomes with targeted therapy, early-stage prognosis remains influenced by pathological factors and central nervous system (CNS) recurrence. The study aimed to clarify prognostic factors in pathological stage (pStage) I EGFR mutation-positive LUAD. METHODS: Between 2015 and 2018, 2,191 pStage I LUAD cases with known EGFR status (excluding EGFR testing after recurrence) who received anatomical resection were included from multiple institutions in Japan. Univariate and multivariate analyses of disease-free survival (DFS) and overall survival (OS) were performed. RESULTS: 1,073 (49.0%) cases harbored EGFR mutations, including 419 (19.1%) with 19del and 529 (24.1%) with L858R. In cases with major EGFR mutation (n = 948), multivariate analysis showed that the absence of noninvasive area (NIA) (hazard ratio [HR]: 1.778, 95% confidence interval [CI]: 1.174-2.692, P = .0065), pStage (IA2 vs. IA1, HR: 2.079, 95% CI: 1.129-3.827, P = .0345; IA3 vs. IA1, HR: 4.009, 95% CI: 2.088-7.696, P = .0001; IB vs. IA1, HR: 5.280, 95% CI: 2.871-9.709, P < .0001), and presence of lymphatic invasion (HR: 1.855, 95% CI: 1.103-3.119, P = .0197) were independent predictors of shorter DFS, and only advanced pStage was an independent predictor of CNS recurrence (relative risk for pStage IA3 or more: 9.729, P < .0001). CONCLUSION: In EGFR mutation-positive pStage I LUAD, those without NIA, with higher pStage and lymphatic invasion were independent predictive factors for DFS, and pStage ≥ IA3 was an independent predictor of CNS recurrence.

    DOI: 10.1016/j.cllc.2024.12.011

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  • 肺癌周術期治療の現在と未来 術前導入化学放射線療法の経験に基づく当院の肺がん周術期治療の現状と工夫

    枝園 和彦, 柳光 剛志, 富岡 泰章, 田中 真, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本癌治療学会学術集会抄録集   62回   OSY1 - 5   2024.10

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  • 局所進行肺癌に対する治療を再考する 切除可能局所進行肺癌に対する導入化学放射線療法の長期成績

    諏澤 憲, 岡田 和大, 柳光 剛志, 富岡 泰章, 田中 真, 枝園 和彦, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本癌治療学会学術集会抄録集   62回   OPD5 - 5   2024.10

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  • 肺移植後の機能性ディスペプシアに対しPEG-J留置が奏功した一例

    柳光 剛志, 杉本 誠一郎, 田中 真, 富岡 泰章, 石原 恵, 堂口 佳子, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   374 - 374   2024.9

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  • 肺移植後長期管理 Up to date 肺移植後の慢性腎臓病に対する長期管理 up to date

    杉本 誠一郎, 柳光 剛志, 富岡 泰章, 田中 真, 石原 恵, 堂口 佳子, 諏澤 憲, 枝園 和彦, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   173 - 173   2024.9

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  • 再肺移植後急性期に膵頭部癌による出血性膵炎を繰り返したNightmare case

    林 龍也, 田中 真, 石原 恵, 堂口 佳子, 梅田 将志, 調枝 治樹, 柳光 剛志, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   59 ( 総会臨時 )   255 - 255   2024.9

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  • 臓器移植レシピエントの感染症 肺移植レシピエントにおける新型コロナウイルス感染症 5類移行後の現状

    妹尾 知哉, 杉本 誠一郎, 調枝 治樹, 柳光 剛志, 富岡 泰章, 田中 真, 石原 恵, 堂口 佳子, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   161 - 161   2024.9

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  • 脳死片肺移植後の抗体関連型拒絶反応に対する集学的治療の経験

    調枝 治樹, 杉本 誠一郎, 柳光 剛志, 富岡 泰章, 田中 真, 堂口 佳子, 石原 恵, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   294 - 294   2024.9

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  • 両側脳死肺移植後のサイトメガロウイルス感染症の予防にレテルモビルが有効だった一例

    俣野 貴慶, 杉本 誠一郎, 田中 真, 柳光 剛志, 調枝 治樹, 富岡 泰章, 堂口 佳子, 石原 恵, 諏澤 憲, 枝園 和彦, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   373 - 373   2024.9

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  • 再肺移植後急性期に膵頭部癌による出血性膵炎を繰り返したNightmare case

    林 龍也, 田中 真, 石原 恵, 堂口 佳子, 梅田 将志, 調枝 治樹, 柳光 剛志, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   59 ( 総会臨時 )   255 - 255   2024.9

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    Language:Japanese   Publisher:(一社)日本移植学会  

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  • 脳死片肺移植後の抗体関連型拒絶反応に対する集学的治療の経験

    調枝 治樹, 杉本 誠一郎, 柳光 剛志, 富岡 泰章, 田中 真, 堂口 佳子, 石原 恵, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   294 - 294   2024.9

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    Language:Japanese   Publisher:(一社)日本移植学会  

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  • 両側脳死肺移植後のサイトメガロウイルス感染症の予防にレテルモビルが有効だった一例

    俣野 貴慶, 杉本 誠一郎, 田中 真, 柳光 剛志, 調枝 治樹, 富岡 泰章, 堂口 佳子, 石原 恵, 諏澤 憲, 枝園 和彦, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   373 - 373   2024.9

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    Language:Japanese   Publisher:(一社)日本移植学会  

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  • 肺移植後の機能性ディスペプシアに対しPEG-J留置が奏功した一例

    柳光 剛志, 杉本 誠一郎, 田中 真, 富岡 泰章, 石原 恵, 堂口 佳子, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   374 - 374   2024.9

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    Language:Japanese   Publisher:(一社)日本移植学会  

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  • 臓器移植レシピエントの感染症 肺移植レシピエントにおける新型コロナウイルス感染症 5類移行後の現状

    妹尾 知哉, 杉本 誠一郎, 調枝 治樹, 柳光 剛志, 富岡 泰章, 田中 真, 石原 恵, 堂口 佳子, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   161 - 161   2024.9

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  • 肺移植後長期管理 Up to date 肺移植後の慢性腎臓病に対する長期管理 up to date

    杉本 誠一郎, 柳光 剛志, 富岡 泰章, 田中 真, 石原 恵, 堂口 佳子, 諏澤 憲, 枝園 和彦, 三好 健太郎, 岡崎 幹生, 豊岡 伸一

    移植   59 ( 総会臨時 )   173 - 173   2024.9

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  • Reply to: “Efficacy and safety of doxycycline versus iodopovidone for pleurodesis through an intercostal tube in malignant pleural effusions: a randomized trial” Reviewed

    Yasuaki Tomioka, Yuki Yoshimatsu, Yasushi Tsujimoto

    Supportive Care in Cancer   2024.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00520-024-08670-5

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  • Impact of central nervous system metastasis after complete resection of lung adenocarcinomas harboring common EGFR mutation - A real-world database study in Japan: The CReGYT-01 EGFR study. Reviewed International journal

    Shinya Katsumata, Mototsugu Shimokawa, Akira Hamada, Naoki Haratake, Kotaro Nomura, Kosuke Fujino, Mao Yoshikawa, Ken Suzawa, Kazuhiko Shien, Kenichi Suda, Shuta Ohara, Shota Fukuda, Fumihiko Kinoshita, Kazuki Hayasaka, Hirotsugu Notsuda, Shinkichi Takamori, Satoshi Muto, Yusuke Takanashi, Kiyomichi Mizuno, Akikazu Kawase, Takamitsu Hayakawa, Keigo Sekihara, Michihito Toda, Somei Matsuo, Kyoshiro Takegahara, Masaki Hashimoto, Kenta Nakahashi, Makoto Endo, Hiroki Ozawa, Ryo Fujikawa, Yasuaki Tomioka, Kei Namba, Taichi Matsubara, Jun Suzuki, Hikaru Watanabe, Kazuki Takada, Hironobu Hoshino, Taisuke Kaiho, Takahide Toyoda, Yasunobu Kouki, Satoshi Shiono, Junichi Soh, Yasuhisa Ohde

    European journal of cancer (Oxford, England : 1990)   201   113951 - 113951   2024.4

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    OBJECTIVES: To clarify the impact of central nervous system (CNS) metastasis on performance status (PS) at relapse, on subsequent treatment(s), and on survival of patients with lung adenocarcinoma harboring common epidermal growth factor receptor (EGFR) mutation. METHODS: We conducted the multicenter real-world database study for patients with radical resections for lung adenocarcinomas between 2015 and 2018 at 21 centers in Japan. EGFR mutational status was examined at each center. RESULTS: Of 4181 patients enrolled, 1431 underwent complete anatomical resection for lung adenocarcinoma harboring common EGFR mutations. Three-hundred-and-twenty patients experienced disease relapse, and 78 (24%) had CNS metastasis. CNS metastasis was significantly more frequent in patients with conventional adjuvant chemotherapy than those without (30% vs. 20%, P = 0.036). Adjuvant chemotherapy did not significantly improve relapse-free survival at any pathological stage (adjusted hazard ratio for stage IA2-3, IB, and II-III was 1.363, 1.287, and 1.004, respectively). CNS metastasis did not affect PS at relapse. Subsequent treatment, mainly consisting of EGFR-tyrosine kinase inhibitors (TKIs), could be equally given in patients with or without CNS metastasis (96% vs. 94%). Overall survival after relapse was equivalent between patients with and without CNS metastasis. CONCLUSION: The efficacy of conventional adjuvant chemotherapy may be limited in patients with lung adenocarcinoma harboring EGFR mutations. CNS metastasis is likely to be found in practice before deterioration in PS, and may have little negative impact on compliance with subsequent EGFR-TKIs and survival after relapse. In this era of adjuvant TKI therapy, further prospective observational studies are desirable to elucidate the optimal management of CNS metastasis.

    DOI: 10.1016/j.ejca.2024.113951

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  • [A Review of 70 Cases of Thoracic Trauma with Rib Fixation:Indications and Practical Innovations of the Procedure]. Reviewed

    Yasuaki Tomioka, Kenta Manabe, Eiji Yamada, Masahiko Muro

    Kyobu geka. The Japanese journal of thoracic surgery   77 ( 4 )   272 - 277   2024.4

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    We summarized the experience of surgical stabilization of rib fractures (SSRF) at a core hospital in eastern Hiroshima, which is a primary center for tertiary emergency medical care, especially for high-energy trauma cases including chest injuries. The study focuses on patients who underwent SSRF from January 2016 to September 2023, analyzing patient characteristics, injury mechanisms, associated injuries, fracture locations, time from injury to surgery, fixation devices used, and postoperative outcomes. Our hospital primarily treats elderly patients, and falls are the most common cause of injury, followed by traffic accidents. The criteria for SSRF in our hospital were clinical manifestations of flail chest, need for lung repair, persistent pain, or improvement of thoracic deformity. We had a high rate of fixation of fractures of the 4th-10th ribs, which have a significant impact on respiratory mechanics; although KANI plates were primarily used, the introduction of MatrixRIB plates offers advantages in certain scenarios. The study also identified challenges with the KANI plate, including cases of plate dislodgement, particularly in patients with multiple fractures and severe thoracic deformities. The combination of video-assisted thoracoscopic surgery and SSRF allows for more effective rib fixation and reduces surgical wound size and muscle damage.

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  • Long-term outcomes of lung transplantation requiring renal replacement therapy: A single-center experience Reviewed

    Yasuaki Tomioka, Seiichiro Sugimoto, Toshio Shiotani, Kei Matsubara, Haruki Choshi, Megumi Ishihara, Shin Tanaka, Kentaroh Miyoshi, Shinji Otani, Shinichi Toyooka

    Respiratory Investigation   2024.3

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    DOI: 10.1016/j.resinv.2024.01.001

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  • Plasma concentrations of histidine-rich glycoprotein in primary graft dysfunction after lung transplantation. Reviewed International journal

    Toshio Shiotani, Seiichiro Sugimoto, Yasuaki Tomioka, Shin Tanaka, Toshiharu Mitsuhashi, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Shinichi Toyooka

    Interdisciplinary cardiovascular and thoracic surgery   2024.2

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    OBJECTIVES: Histidine-rich glycoprotein has been reported as an anti-inflammatory glycoprotein that inhibits acute lung injury in mice with sepsis and as a prognostic biomarker in patients with sepsis. We investigated the relationship between plasma concentrations of histidine-rich glycoprotein and the risk of occurrence of primary graft dysfunction. METHODS: According to the primary graft dysfunction grade at post-transplant 72 hours, patients who underwent lung transplantation were divided into three groups: non-primary graft dysfunction group (grade 0-1), moderate primary graft dysfunction group (grade 2), and severe primary graft dysfunction group (grade 3). The plasma concentrations of histidine-rich glycoprotein measured daily during the first post-transplant 7 days were compared among the three groups. Appropriate cutoff values of the concentrations were set for survival analyses after lung transplantation. RESULTS: A total of 68 patients were included. The plasma histidine-rich glycoprotein concentration at post-transplant 72 hours was significantly lower in the severe primary graft dysfunction group (n = 7) than in the other two groups (non-primary graft dysfunction group (n = 43), P = 0.042; moderate primary graft dysfunction group (n = 18), P = 0.040). Patients with plasma histidine-rich glycoprotein concentration ≥34.4 µg/mL at post-transplant 72 hours had significantly better chronic lung allograft dysfunction-free survival (P = 0.012) and overall survival (P = 0.037) than those with the concentration <34.4 µg/mL. CONCLUSIONS: Plasma histidine-rich glycoprotein concentrations at post-transplant 72 hours might be associated with the risk of development of primary graft dysfunction.

    DOI: 10.1093/icvts/ivae021

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  • Pulmonary ligament rupture due to a bronchial artery aneurysm-induced hematoma: a case report Reviewed

    Yasuaki Tomioka, Eiji Yamada, Tsuyoshi Hyodo, Masahiko Muro

    Surgical Case Reports   2024.1

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40792-024-01810-3

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  • Successful Living-donor Lobar Lung Transplantation With BK Virus-related Hemorrhagic Cystitis Throughout the Perioperative Period. Reviewed International journal

    Yasuaki Tomioka, Shinji Otani, Shin Tanaka, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Transplantation direct   10 ( 1 )   e1556   2024.1

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    DOI: 10.1097/TXD.0000000000001556

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  • Comment on: "Randomized Controlled Trial of Surgical Rib Fixation to Nonoperative Management in Severe Chest Wall Injury". Reviewed International journal

    Yasuaki Tomioka

    Annals of surgery open : perspectives of surgical history, education, and clinical approaches   4 ( 4 )   e360   2023.12

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    Authorship:Lead author, Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/AS9.0000000000000360

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  • In vivo lung perfusion for prompt recovery from primary graft dysfunction after lung transplantation. Reviewed International journal

    Kei Matsubara, Kentaroh Miyoshi, Shinichi Kawana, Yujiro Kubo, Dai Shimizu, Yasuaki Tomioka, Toshio Shiotani, Haruchika Yamamoto, Shin Tanaka, Takeshi Kurosaki, Toshiaki Ohara, Mikio Okazaki, Seiichiro Sugimoto, Akihiro Matsukawa, Shinichi Toyooka

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation   2023.10

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    BACKGROUND: No proven treatment after the development of primary graft dysfunction (PGD) is currently available. Here we established a novel strategy of in vivo lung perfusion (IVLP) for the treatment of PGD. IVLP involves the application of an in vivo isolated perfusion circuit to an implanted lung. This study aimed to explore the effectiveness of IVLP versus conventional post-lung transplant (LTx) extracorporeal membrane oxygenation (ECMO) treatment using an experimental swine LTx PGD model. METHODS: After 1.5-h warm ischemia of the donor lungs, a left LTx was performed. Following the confirmation of PGD development, pigs were divided into three groups (n = 5 each): control (no intervention), ECMO, and IVLP. After 2 h of treatment, a 4-h functional assessment was conducted and samples obtained. RESULTS: Significantly better oxygenation were achieved in the IVLP group (p ≤ 0.001). Recovery was confirmed immediately and maintained during the following 4-h observation. The IVLP group also demonstrated better lung compliance than the control group (p = 0.045). A histological evaluation showed that the lung injury score and terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed significantly fewer injuries and a better result in the wet-to-dry weight ratio in the IVLP group. CONCLUSIONS: A two-hour IVLP is technically feasible and allows for prompt recovery from PGD after LTx. The posttransplant short-duration IVLP strategy can complement or overcome the limitations of the current practice for donor assessment and PGD management.

    DOI: 10.1016/j.healun.2023.10.011

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  • Author Correction: Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array. International journal

    Yasuaki Tomioka, Seiichiro Sugimoto, Haruchika Yamamoto, Shuta Tomida, Toshio Shiotani, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Scientific reports   13 ( 1 )   16721 - 16721   2023.10

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    DOI: 10.1038/s41598-023-43995-x

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  • ドナー因子と肺移植成績 岡山大学脳死肺移植例におけるドナー因子と短・長期アウトカム

    三好 健太郎, 田中 真, 杉本 誠一郎, 調枝 治樹, 松原 慧, 富岡 泰章, 塩谷 俊雄, 橋本 好平, 黒崎 毅史, 大谷 真二, 岡崎 幹夫, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   76回   LPD2 - 4   2023.10

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  • Successful management of temporary veno-venous extracorporeal membrane oxygenation for a pediatric lung transplant recipient with bronchiolitis obliterans syndrome awaiting lung re-transplantation: a case report. Reviewed International journal

    Yasuaki Tomioka, Kentaroh Miyoshi, Shin Tanaka, Seiichiro Sugimoto, Rie Kanai, Tetsuro Nikai, Shinichi Toyooka, Masaomi Yamane

    Surgical case reports   9 ( 1 )   163 - 163   2023.9

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    BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation is an uncommon strategy in Japan owing to the severe donor shortage and absence of urgent allocation policy. Moreover, the use of veno-venous (VV) ECMO for immunosuppressed patients is controversial; thus, applying ECMO to patients who await lung re-transplantation is challenging. CASE PRESENTATION: A 16-year-old lung transplant recipient with grade 3 bronchiolitis obliterans syndrome was waitlisted for lung re-transplantation. Eleven months later, he fell into severe respiratory acidosis with hypercapnia, which were not resolved with mechanical ventilation. VV ECMO was introduced to minimize lung stress and strain. Tracheostomy was additionally performed on day 5 after the start of ECMO, and respiratory condition swiftly improved; hence, the weaning process from VV ECMO began on day 9. Rehabilitation became implementable, and bilateral re-lung transplantation was successfully performed 6 months after the ECMO treatment. No critical complication related to the precedent use of ECMO was noted. CONCLUSIONS: VV ECMO can be a feasible treatment option even for lung transplant candidates awaiting re-transplantation for a prolonged period. Introduction of ECMO and tracheostomy in the early deterioration stage may be crucial to successful subsequent patient management.

    DOI: 10.1186/s40792-023-01742-4

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  • Robot-assisted thoracoscopic right upper lobectomy with displaced B3 and absence of minor fissure: a case report Reviewed

    Yasuaki Tomioka, Jo Watanabe, Norichika Iga, Masaomi Yamane

    Surgical and Radiologic Anatomy   2023.7

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    DOI: 10.1007/s00276-023-03197-6

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  • Elderly lung transplant recipients show acceptable long-term outcomes for lung transplantation: A propensity score-matched analysis. Reviewed

    Yasuaki Tomioka, Shin Tanaka, Shinji Otani, Toshio Shiotani, Haruchika Yamamoto, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   2023.6

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    PURPOSE: Although the performance lung transplantation (LTx) in the elderly (≥ 60 years) has increased globally, the situation in Japan remains quite different, because the age limit at registration for cadaveric transplantation is 60 years. We investigated the long-term outcomes of LTx in the elderly in Japan. METHODS: This was a single-center retrospective study. We divided the patients into two groups according to age: the younger group (< 60 years; Y group; n = 194) and the elderly group (≥ 60 years; E group; n = 10). We performed three-to-one propensity score matching to compare the long-term survival between the E and Y groups. RESULTS: In the E group, the survival rate was significantly worse (p = 0.003), and single-LTx was more frequent (p = 0.036). There was a significant difference in the indications for LTx between the two groups (p < 0.001). The 5-year survival rate after single-LTx in the E group was significantly lower than that in the Y group (p = 0.006). After propensity score matching, the 5-year survival rates of the two groups were comparable (p = 0.55). However, the 5-year survival rate after single-LTx in the E group was significantly lower than that in the Y group (p = 0.007). CONCLUSION: Elderly patients showed acceptable long-term survival after LTx.

    DOI: 10.1007/s00595-023-02699-5

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  • Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array. Reviewed International journal

    Yasuaki Tomioka, Seiichiro Sugimoto, Haruchika Yamamoto, Shuta Tomida, Toshio Shiotani, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Scientific reports   13 ( 1 )   8912 - 8912   2023.6

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    Renal dysfunction is a long-term complication associated with an increased mortality after lung transplantation (LT). We investigated the association of single-nucleotide polymorphisms (SNPs) with the development of renal dysfunction after LT using a Japanese-specific SNP array. First, eligible samples of 34 LT recipients were genotyped using the SNP array and divided into two groups, according to the presence of homozygous and heterozygous combinations of mutant alleles of the 162 renal-related SNPs. To identify candidate SNPs, the renal function tests were compared between the two groups for each SNP. Next, we investigated the association between the candidate SNPs and the time course of changes of the estimated glomerular filtration rate (eGFR) in the 99 recipients until 10 years after the LT. ΔeGFR was defined as the difference between the postoperative and preoperative eGFR values. Eight SNPs were identified as the candidate SNPs in the 34 recipients. Validation analysis of these 8 candidate SNPs in all the 99 recipients showed that three SNPs, namely, rs10277115, rs4690095, and rs792064, were associated with significant changes of the ΔeGFR. Pre-transplant identification of high-risk patients for the development of renal dysfunction after LT based on the presence of these SNPs might contribute to providing personalized medicine.

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  • 右B3転位気管支および分葉不全を伴う右上葉肺癌に対してロボット支援下右上葉切除術を施行した1例

    渡辺 青, 富岡 泰章, 伊賀 徳周, 山根 正修

    日本呼吸器外科学会雑誌   37 ( 3 )   P34 - 2   2023.6

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  • Diagnostic value of circulating microRNA-21 in chronic lung allograft dysfunction after bilateral cadaveric and living-donor lobar lung transplantation. Reviewed International journal

    Toshio Shiotani, Seiichiro Sugimoto, Yasuaki Tomioka, Haruchika Yamamoto, Shin Tanaka, Kentaroh Miyoshi, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Shinichi Toyooka

    Heliyon   9 ( 4 )   e14903   2023.4

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    BACKGROUND: MicroRNAs (miRNAs) involved in the pathogenesis of pulmonary fibrosis have been shown to be associated with the development of chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). We investigated the role of circulating miRNAs in the diagnosis of CLAD after bilateral LT, including cadaveric LT (CLT) and living-donor lobar LT (LDLLT). METHODS: The subjects of this retrospective study were 37 recipients of bilateral CLT (n = 23) and LDLLT (n = 14), and they were divided into a non-CLAD group (n = 24) and a CLAD group (n = 13). The plasma miRNA levels of the two groups were compared, and correlations between their miRNAs levels and percent baseline forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and total lung capacity (TLC) values were calculated from one year before to one year after the diagnosis of CLAD. RESULTS: The plasma levels of both miR-21 and miR-155 at the time of the diagnosis of CLAD were significantly higher in the CLAD group than in the non-CLAD group (miR-21, P = 0.0013; miR-155, P = 0.042). The miR-21 levels were significantly correlated with the percent baseline FEV1, FVC, and TLC value of one year before and at the time of diagnosis of CLAD (P < 0.05). A receiver operating characteristic curve analysis of the performance of miR-21 levels in the diagnosis of CLAD yielded an area under the curve of 0.89. CONCLUSION: Circulating miR-21 appears to be of potential value in diagnosing CLAD after bilateral LT.

    DOI: 10.1016/j.heliyon.2023.e14903

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  • Combined minimally invasive surgery for a dumbbell tumor using spinal endoscopy and robot-assisted intrathoracic surgery: a case report Reviewed

    Yasuaki Tomioka

    Video-Assisted Thoracic Surgery   2023

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    DOI: 10.21037/VATS-22-61

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  • The impact of prognostic nutrition index on the waitlist mortality of lung transplantation. Reviewed

    Kei Matsubara, Shinji Otani, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    General thoracic and cardiovascular surgery   2022.12

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    OBJECTIVE: The prognostic nutrition index (PNI), calculated using serum albumin and total lymphocyte count, is a recent topical index related to inflammation. Preoperative PNI is regarded as a new preoperative prognostic score in lung transplantation (LTx). This study aimed to investigate the impact of PNI at the time of registration as a prognostic parameter of mortality on the waiting list for LTx. METHODS: A retrospective review was conducted on the data of 132 adult patients registered for LTx in our department between January 2013 and June 2020. Patients who finally received LTx were analyzed as censored data. The overall survival was evaluated using the Kaplan-Meier method for pre-registered clinical factors including the PNI at the time of registration. Overall survival was calculated from the date of listing to the Japan Organ Transplant Network to the date of death. RESULTS: The low-PNI group had a significantly worse prognosis. Multivariate analysis demonstrated that age (p = 0.023), idiopathic interstitial pneumonia (p < 0.001), lung allocation score (LAS) (p < 0.001), and PNI (p < 0.001) were independent prognostic factors for waitlist mortality. CONCLUSIONS: PNI at the time of registration can be an independent prognostic parameter in registered candidates for LTx.

    DOI: 10.1007/s11748-022-01895-3

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  • 大動脈合併切除を施行した局所進行肺癌

    山根 正修, 富岡 泰章, 伊賀 徳周, 清水 弘治, 末廣 章一, 織田 禎二

    日本臨床外科学会雑誌   83 ( 12 )   2161 - 2161   2022.12

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  • 大動脈合併切除を施行した局所進行肺癌

    山根 正修, 富岡 泰章, 伊賀 徳周, 清水 弘治, 末廣 章一, 織田 禎二

    日本臨床外科学会雑誌   83 ( 12 )   2161 - 2161   2022.12

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  • 本邦における肺移植時の一酸化窒素(NO)ガス使用状況に関する実態調査 Reviewed

    吉安 展将, 佐藤 雅昭, 中島 大輔, 富岡 泰章, 渡辺 有為, 白石 武史, 舟木 壮一郎, 前田 寿美子, 朝重 耕一, 中島 崇裕, 土谷 智史, 杉本 誠一郎, 吉野 一郎, 永安 武, 千田 雅之, 南 正人, 岡田 克典, 豊岡 伸一, 伊達 洋至, 中島 淳

    日本呼吸器外科学会雑誌   36 ( 7 )   722 - 734   2022.11

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  • 本邦における肺移植時の一酸化窒素(NO)ガス使用状況に関する実態調査

    吉安 展将, 佐藤 雅昭, 中島 大輔, 富岡 泰章, 渡辺 有為, 白石 武史, 舟木 壮一郎, 前田 寿美子, 朝重 耕一, 中島 崇裕, 土谷 智史, 杉本 誠一郎, 吉野 一郎, 永安 武, 千田 雅之, 南 正人, 岡田 克典, 豊岡 伸一, 伊達 洋至, 中島 淳

    日本呼吸器外科学会雑誌   36 ( 7 )   722 - 734   2022.11

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    【背景】2021年1月現在,本邦の肺移植手術において一酸化窒素(Nitric Oxide,NO)吸入療法は保険外診療である.本研究では肺移植時のNO吸入療法の使用状況とその安全性に関する実態調査を行った.【方法】2015年1月1日から2019年12月31日の間,本邦で行った肺移植手術症例,肺移植実施全9施設を対象にNO吸入療法の治療期間や副作用について調査した.【結果】対象期間に357例の肺移植が行われ,NO吸入療法は349例(98%)で施行された.NO初回投与濃度は中央値10ppm,最大投与濃度は中央値20ppmであった.術中から継続された症例が313例(90%)あり,中央値4日間使用されていた.酸素化や肺動脈圧の有意な改善効果を認めた.メトヘモグロビン血症等の副作用は15例(4%)で認められ,18歳未満の小児症例で有意に発症した.【結論】本邦の肺移植手術ではほぼ全例でNO吸入療法がなされ,一定の効果が示された.従って,肺移植時のNO吸入療法に対して,公的医療保険の適用が推奨される.(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J02256&link_issn=&doc_id=20221129360001&doc_link_id=10.2995%2Fjacsurg.36.722&url=https%3A%2F%2Fdoi.org%2F10.2995%2Fjacsurg.36.722&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • 肺癌低侵襲手術のニューウエーブ:RATS、Uniportal VATSの適応拡大とピットフォール ロボット支援下胸腔鏡手術における死亡事例の検討? RATS特有のピットフォールを認識し、安全な手術を目指す

    山根 正修, 富岡 泰章, 伊賀 徳周

    日本胸部外科学会定期学術集会   75回   LPD2 - 5   2022.10

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  • COVID-19パンデミックがもたらした臨床実習における功罪

    山根 正修, 富岡 泰章, 伊賀 徳周

    医学教育   53 ( Suppl. )   241 - 241   2022.7

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  • Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma. Reviewed International journal

    Fumiaki Takatsu, Hiromasa Yamamoto, Yasuaki Tomioka, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Shinichi Toyooka

    World journal of surgical oncology   20 ( 1 )   114 - 114   2022.4

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    BACKGROUND: Soft-tissue sarcomas are rare malignancies that consist of many different histologic subtypes and arise in various locations in the body. In patients with lung metastases from retroperitoneal sarcomas, the long-term outcomes and prognostic factors are unknown. This study is a retrospective review of patients undergoing pulmonary metastasectomy for retroperitoneal sarcoma metastases at one institution, with the purpose of determining prognostic factors and clinical outcomes. METHODS: This is a single-center, retrospective cohort study of patients undergoing pulmonary metastasectomy for lung metastases from various sarcomas at Okayama University Hospital from January 2006 to December 2018. The Kaplan-Meier method and log-rank test were used for the analyses, and cut-off values of continuous variables were determined by a receiver operating characteristic curve analysis. RESULTS: Twenty-four patients underwent the first pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma in our hospital. Leiomyosarcoma was the most common histologic subtype of retroperitoneal sarcoma (79.2%, n = 19). Median overall survival was 49.9 months, and the 3-year and 5-year survival rates after the first pulmonary metastasectomy were 62.5% and 26.4% respectively. In univariate analysis, age ≥56 years, disease-free interval < 15 months, and size of metastasis (≥ 27 mm) were associated with poor survival. CONCLUSION: Pulmonary metastasectomy can be considered as an effective management strategy in retroperitoneal sarcoma patients with lung metastases in appropriately selected cases, just as it is for other sarcomas.

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  • Lung Transplantation for Bronchiectasis Due to Hyperimmunoglobulin E Syndrome. Reviewed International journal

    Dai Shimizu, Shinji Otani, Seiichiro Sugimoto, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    The Annals of thoracic surgery   113 ( 4 )   e251-e253   2022.4

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    Hyperimmunoglobulin E syndrome (HIES) is one of the primary immunodeficiencies characterized by recurrent staphylococcal skin and lung infections that result in lung destruction and critically diminished pulmonary function. Despite the lack of definitive treatment, there have been no reports of successful lung transplantation for HIES patients. We report the case of a 42-year-old woman with HIES with progressive bronchiectasis whose pulmonary infection was controlled before transplantation, and subsequent lung transplantation was uneventful. Lung transplantation may be feasible in HIES if the patient is immunologically stable preoperatively and perioperative infections, especially Aspergillus infections, are well controlled.

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  • Effect of preoperative long-term use of corticosteroids on the development of post-transplant lymphoproliferative disorders after lung transplantation: a single-center experience in Japan. Reviewed

    Dai Shimizu, Shinji Otani, Seiichiro Sugimoto, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Surgery today   52 ( 4 )   697 - 704   2022.4

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    PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) is a major complication of lung transplantation (LTx). However, few studies on PTLD in Asian populations have been reported. We explored the characteristics of Japanese PTLD cases after LTx. METHODS: We retrospectively reviewed 195 cases of LTx at our institute. We summarized the clinical experiences of 7 PTLD cases and analyzed the patient characteristics and survival outcomes of patients with (n = 7) and without (n = 188) PTLD. RESULTS: All PTLD patients were taking corticosteroids preoperatively (p = 0.0030), and the duration of preoperative corticosteroid therapy was significantly longer in the PTLD group (p = 0.0064) than in the non-PTLD group. The overall survival after LTx was significantly worse in the PTLD group (p = 0.027) than in the non-PLTD group. Among the three patients who died within 1 year after the PTLD onset, two died of opportunistic infections without residual PTLD lesions. Chronic lung allograft dysfunction (CLAD) or bronchiolitis obliterans at an autopsy were diagnosed after PTLD treatment in four cases. CONCLUSIONS: Long-term preoperative corticosteroid therapy may be a risk factor for PTLD after LTx. Opportunistic infections are lethal complications of PTLD, regardless of the effectiveness of PTLD treatment. CLAD occurs at a high rate after PTLD treatment, and close monitoring is required.

    DOI: 10.1007/s00595-021-02390-7

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  • Paediatric lung transplantation: the impact of age on the survival. Reviewed

    Shinji Otani, Haruchika Yamamoto, Shin Tanaka, Yasuaki Tomioka, Kei Matsubara, Dai Shimizu, Toshio Shiotani, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   52 ( 11 )   1540 - 1550   2022.3

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    OBJECTIVES: We herein review the outcomes of paediatric lung transplantation (LTx) and analyse subgroups divided by age. METHODS: We retrospectively reviewed 43 consecutive paediatric LTx recipients (< 18 years old: cadaveric LTx [n = 9], living-donor lobar LTx [n = 34]). We also analysed subgroups of patients 1-6 years old (n = 10) and 7-17 years old (n = 33). RESULTS: The 1-, 5- and 10-year overall survival (OS) rates in paediatric recipients were 93%, 82% and 67%, respectively. The 1-, 5- and 10-year graft dysfunction (GD)-free survival rates in paediatric recipients were 85%, 59% and 31%, respectively. The 1- and 5-year OS in the 1- to 6-year-old vs. 7- to 17-year-old groups were 70% vs. 100% and 48% vs. 93%, respectively (p < 0.0001). The 1- and 5-year GD-free survival rates in the 1- to 6-year-old vs. 7- to 17-year-old groups were 60% vs. 93% and 24% vs. 69%, respectively (p = 0.024). The 1- to 6-year-old group showed higher rates of non-standard LTx (p = 0.0001), interstitial pneumonia (p = 0.004) and ventilator dependency (p = 0.007) than the 7- to 17-year-old group. CONCLUSION: Paediatric recipients under 7 years old seemed to have a higher risk of mortality and GD than those 7 years old and older.

    DOI: 10.1007/s00595-022-02492-w

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  • Acute Pulmonary Edema Due to Arteriovenous Shunt Placement after Lung Transplant. Reviewed International journal

    Dai Shimizu, Kentaroh Miyoshi, Seiichiro Sugimoto, Tomoko Toma, Yusuke Matsuda, Yasuaki Tomioka, Toshio Shiotani, Shinji Otani, Masaomi Yamane, Shinichi Toyooka

    The Annals of thoracic surgery   2022.1

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    Lung transplant recipients are often complicated by immunosuppressant-induced nephropathy, which may require renal replacement therapy. We report a case of unilateral lung edema and pulmonary hypertension due to arteriovenous fistula placement in a patient with unilateral chronic lung allograft dysfunction after bilateral living-donor lobar lung transplantation. Lung transplant recipients with limited residual vascular beds, such as lobar graft or severe deviation in lung perfusion, are vulnerable to the acute increase in blood flow due to arteriovenous fistula placement and can easily develop pulmonary edema regardless of the left ventricular function. Hence, careful volume control is required.

    DOI: 10.1016/j.athoracsur.2021.12.017

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  • 血漿Histidine-rich glycoprotein濃度と肺移植後一時移植機能不全との関係

    塩谷 俊雄, 杉本 誠一郎, 富岡 泰章, 田中 真, 諏澤 憲, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LOD17 - 1   2021.10

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  • 綿密な術前準備を行った低肺機能患者の両側続発性高度気胸の1手術例

    土生 智大, 諏澤 憲, 坂田 龍平, 久保 友次郎, 岩田 一馬, 松田 直樹, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LCPA2 - 1   2021.10

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  • 片肺移植における二次性肺高血圧の影響 当院の片側脳死肺移植症例の検討から

    清水 大, 三好 健太郎, 杉本 誠一郎, 久保 友次郎, 川名 伸一, 富岡 泰章, 松原 慧, 田中 真, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LOP15 - 2   2021.10

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  • 当院での様々な開胸アプローチの経験

    田中 真, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   572 - 572   2021.10

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  • Current status of inhaled nitric oxide therapy for lung transplantation in Japan: a nationwide survey. Reviewed

    Nobuyuki Yoshiyasu, Masaaki Sato, Daisuke Nakajima, Yasuaki Tomioka, Yui Watanabe, Takeshi Shiraishi, Soichiro Funaki, Sumiko Maeda, Koichi Tomoshige, Takahiro Nakajima, Tomoshi Tsuchiya, Seiichiro Sugimoto, Ichiro Yoshino, Takeshi Nagayasu, Masayuki Chida, Masato Minami, Yoshinori Okada, Shinichi Toyooka, Hiroshi Date, Jun Nakajima

    General thoracic and cardiovascular surgery   69 ( 10 )   1421 - 1431   2021.10

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    OBJECTIVES: Currently, inhaled nitric oxide (NO) therapy for lung transplantation is not covered by public health insurance in Japan. In this study, we evaluated the perioperative use and safety of inhaled NO therapy for lung transplantation. METHODS: Data regarding the duration of treatment and adverse events of inhaled NO therapy were collected for all lung transplantations performed from January 1, 2015, to December 31, 2019, at nine lung transplant facilities in Japan. RESULTS: During the study period, lung transplants were performed in 357 patients, among whom inhaled NO therapy was administered to 349 patients (98%). The median initial and median maximum inhaled NO doses were 10 and 20 ppm, respectively. Inhaled NO therapy was introduced during surgery and continued postoperatively in 313 patients (90%) for a median of 4 days. Significant improvements in oxygenation and decreases in pulmonary arterial pressure were observed in patients receiving inhaled NO therapy. Side effects of inhaled NO therapy, such as methemoglobinemia, were observed in 15 patients (4%), with a significant incidence in patients aged < 18 years. CONCLUSIONS: Inhaled NO therapy was performed in almost all patients who underwent lung transplantation in Japan and showed reasonable efficacy. Therefore, public health insurance coverage for inhaled NO therapy during lung transplantation is recommended.

    DOI: 10.1007/s11748-021-01648-8

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  • Lung transplantation for idiopathic multicentric Castleman disease: potential efficacy and tolerability of a humanized anti-interleukin-6 receptor monoclonal antibody. Reviewed International journal

    Yasuaki Tomioka, Shinji Otani, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgical case reports   7 ( 1 )   209 - 209   2021.9

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    BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a rare polyclonal lymphoproliferative disease caused by the overrepresentation of interleukin-6 (IL-6). Tocilizumab (TCZ) is a humanized monoclonal antibody that binds to the IL-6 receptor and is approved for the treatment of iMCD. The efficacy and tolerability of TCZ in patients with iMCD undergoing lung transplantation (LTx) remain unknown. CASE PRESENTATION: We present the case of a 48-year-old iMCD patient with end-stage lung disease (ESLD) who was successfully treated with cadaveric single-LTx. Intravenous TCZ was used to stabilize the iMCD patient every 2 weeks, except for withdrawal immediately after LTx. At 32 month post-transplant, the patient remained asymptomatic without evidence of rejection, development of de novo donor-specific antibody (DSA), and recurrent iMCD in the native lung. CONCLUSIONS: Single-LTx can be a feasible treatment option for ESLD caused by iMCD. TCZ can be used safely and may be beneficial in recipients with iMCD, and TCZ in combination with usual immunosuppression can be helpful in stabilizing iMCD patients pre- and post-LTx.

    DOI: 10.1186/s40792-021-01297-2

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  • 肺移植に関連した感染症(待機中から術後慢性期まで) びまん性汎細気管支炎に対する肺移植後の慢性期管理と長期成績

    杉本 誠一郎, 三好 健太郎, 田中 真, 富岡 泰章, 石原 恵, 石上 恵美, 諏澤 憲, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY4 - 5   2021.9

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  • 肺移植におけるドナー不足にどう取組むか 心停止ドナー肺移植、スペインでの経験を踏まえて

    田中 真, 石上 恵美, 石原 恵, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY9 - 4   2021.9

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  • 肺移植に関連した感染症(待機中から術後慢性期まで) Clostridioides difficile感染症診療ガイドライン作成に伴う当院での肺移植周術期の検討

    久保 友次郎, 田中 真, 石上 恵美, 石原 恵, 坂田 龍平, 富岡 泰章, 枝園 和彦, 諏澤 憲, 大谷 真二, 山本 寛斉, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY4 - 4   2021.9

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  • The prognostic impact of sarcopenia on elderly patients undergoing pulmonary resection for non-small cell lung cancer. Reviewed

    Akihiro Miura, Hiromasa Yamamoto, Hiroki Sato, Yasuaki Tomioka, Toshio Shiotani, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   51 ( 7 )   1203 - 1211   2021.7

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    PURPOSE: The number of elderly patients who undergo surgery is increasing, even though they are at a high risk due to a decreased physical strength. Furthermore, sarcopenia is generally associated with a poor prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: This study included NSCLC patients  ≥ 65 years old who underwent pulmonary resection in our hospital between 2012 and 2015. Sarcopenia was assessed using the psoas muscle mass index based on computed tomography at the level of the third lumbar vertebra. We elucidated the impact of sarcopenia on short- and long-term outcomes after surgery. RESULTS: We enrolled 259 patients, including 179 with sarcopenia. Patients with sarcopenia before surgery tended to have postoperative complications (p = 0.0521), although they did not show a poor prognosis. In patients with sarcopenia, a multivariate analysis revealed that postoperative complications and the progression of sarcopenia 1 year after surgery were significant risk factors for a poor prognosis (p = 0.0169 and 0.00370, respectively). CONCLUSIONS: The progression of sarcopenia after surgery is associated with a poor prognosis in elderly NSCLC patients with sarcopenia. A strategy to prevent postoperative progressive sarcopenia may be necessary for improving the clinical outcome of this population.

    DOI: 10.1007/s00595-020-02221-1

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  • 本邦における肺移植時の一酸化窒素ガス(NO)使用状況に関する実態調査

    吉安 展将, 佐藤 雅昭, 中島 大輔, 富岡 泰章, 渡辺 有為, 白石 武史, 舟木 壮一郎, 前田 寿美子, 朝重 耕一, 中島 崇裕, 土谷 智史, 杉本 誠一郎, 吉野 一郎, 永安 武, 千田 雅之, 南 正人, 岡田 克典, 豊岡 伸一, 伊達 洋至, 中島 淳

    移植   56 ( 1 )   88 - 88   2021.7

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  • 肺移植後移植片慢性機能不全におけるGoddard scoreの検討

    塩谷 俊雄, 杉本 誠一郎, 山本 治慎, 富岡 泰章, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O18 - 3   2021.5

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  • 肺移植における予後改善に向けての取組 生体肺移植と脳死肺移植の違いに着目した慢性移植肺機能不全(CLAD)の早期診断を目指した取り組み

    杉本 誠一郎, 塩谷 俊雄, 山本 治慎, 富岡 泰章, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   PD2 - 4   2021.5

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  • 肺移植における最適な術前予後予測スコアリング法 9つの術前予後予測スコアリング法の検証から

    山本 治慎, 杉本 誠一郎, 富岡 泰章, 塩谷 俊雄, 清水 大, 松原 慧, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O18 - 5   2021.5

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  • N2肺癌に対する術前導入化学放射線療法後手術症例における好中球/リンパ球比の検討

    山本 寛斉, 津高 慎平, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O8 - 1   2021.5

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  • UNCX遺伝子多型と肺移植後の腎機能障害との関係

    富岡 泰章, 杉本 誠一郎, 山本 治慎, 清水 大, 松原 慧, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   RO17 - 2   2021.5

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  • 当院における小児肺移植の成績

    大谷 真二, 富岡 泰章, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本外科学会定期学術集会抄録集   121回   PS - 8   2021.4

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  • 脳死肺移植後、タクロリムス濃度調整に難渋した、クローン病合併レシピエントの1例

    松原 慧, 大谷 真二, 金 聖暎, 今井 祥子, 開原 裕子, 長谷川 祐子, 清水 大, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   508 - 508   2021.3

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  • 小児に対するABO血液型不一致の両側脳死肺移植の経験

    塩谷 俊雄, 杉本 誠一郎, 松原 慧, 富岡 泰章, 清水 大, 山本 治慎, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   491 - 491   2021.3

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  • 脳死片肺移植を施行した多中心性キャッスルマン病の1例

    富岡 泰章, 大谷 真二, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   506 - 506   2021.3

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  • 高IgE症候群による気管支拡張症に対して両側脳死肺移植を施行した1例

    清水 大, 大谷 真二, 富岡 泰章, 松原 慧, 塩谷 俊雄, 山本 治慎, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   507 - 507   2021.3

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  • 小児に対するABO血液型不一致の両側脳死肺移植の経験

    塩谷 俊雄, 杉本 誠一郎, 松原 慧, 富岡 泰章, 清水 大, 山本 治慎, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   491 - 491   2021.3

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  • 高IgE症候群による気管支拡張症に対して両側脳死肺移植を施行した1例

    清水 大, 大谷 真二, 富岡 泰章, 松原 慧, 塩谷 俊雄, 山本 治慎, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   507 - 507   2021.3

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  • Successful Bronchoscopic Treatment for Postoperative Bronchopleural Fistula Using N-butyl-2-cyanoacrylate (NBCA): Report of a Post-completion Pneumonectomy Case with a History of Induction Chemoradiotherapy Followed by Bilobectomy for Advanced Lung Cancer. Reviewed

    Toshio Shiotani, Hiromasa Yamamoto, Riko Katsube, Yasuaki Tomioka, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   75 ( 1 )   91 - 94   2021.2

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    Bronchopleural fistula (BPF) is a severe complication following lung resection. We present the case of a patient with a history of advanced lung cancer, who had undergone induction chemoradiotherapy followed by right middle and lower lobectomy, and who developed BPF after completion right pneumonectomy. Although we had covered the bronchial stump with an omental pedicled flap, BPF was found on postoperative day 19. We covered the fistula with n-butyl-2-cyanoacrylate (NBCA) using bronchoscopy. Although we had to repeat the NBCA treatment, we ultimately cured the patient's BPF and no recurrence was observed up to 15.2 months after surgery.

    DOI: 10.18926/AMO/61440

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  • Long-term Follow-up of Living-Donor Kidney Transplantation after Cadaveric Lung Transplantation. Reviewed

    Toshio Shiotani, Seiichiro Sugimoto, Kota Araki, Yasuaki Tomioka, Kentaroh Miyoshi, Shinji Otani, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   75 ( 1 )   87 - 89   2021.2

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    Although chronic kidney disease (CKD) commonly develops after lung transplantation (LT), living-donor kid-ney transplantation (LDKT) for CKD after LT is known to provide favorable outcomes. We describe the long-term follow-up findings of a patient who underwent LDKT after bilateral cadaveric LT. A 37-year-old male underwent LDKT for CKD 18 years after receiving bilateral cadaveric LT. He developed chronic lung allograft dysfunction (CLAD) 20 years after the LT; however, at 26 years after the initial LT, he is still alive with no pro-gression of CLAD or CKD. KT could be a viable option for CKD even after LT in Japan.

    DOI: 10.18926/AMO/61439

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  • 間質性肺炎合併肺癌:To treat, or not to treat? 間質性肺炎合併肺癌に対する外科的治療

    山本 寛斉, 松原 慧, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   481 - 481   2020.10

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  • ハイリスク症例をいかに手術に繋げるか? 導入放射線化学療法後の局所進行非小細胞肺癌に対する手術後に反回神経麻痺を発症した症例の検討

    杉本 誠一郎, 諏澤 憲, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   492 - 492   2020.10

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  • 間質性肺炎合併肺癌:To treat, or not to treat? 間質性肺炎合併肺癌に対する外科的治療

    山本 寛斉, 松原 慧, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   481 - 481   2020.10

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  • ハイリスク症例をいかに手術に繋げるか? 導入放射線化学療法後の局所進行非小細胞肺癌に対する手術後に反回神経麻痺を発症した症例の検討

    杉本 誠一郎, 諏澤 憲, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   492 - 492   2020.10

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  • 非小細胞肺癌手術症例と末梢血リンパ球/単球比とその継時的変化の関連の検討

    富岡 泰章, 山本 寛斉, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   587 - 587   2020.10

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  • 当院の肺移植後リンパ増殖性疾患7例の検討 治療後のCLAD発症と日和見感染症による死亡をどう防ぐか

    清水 大, 大谷 真二, 富岡 泰章, 松原 慧, 塩谷 俊雄, 山本 治慎, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   246 - 246   2020.10

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  • 肺移植待機患者の予後予測におけるPrognostic Nutrition Index(PNI)の有用性

    松原 慧, 大谷 真二, 清水 大, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   353 - 353   2020.10

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  • Thoracoscopic rib resection and reconstruction of chest wall: Our clinical experience. Reviewed

    Yuichiro Ueda, Tatsuo Nakagawa, Yasuaki Tomioka, Toshiya Toyazaki, Masashi Gotoh

    Asian journal of endoscopic surgery   13 ( 1 )   121 - 123   2020.1

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    Chest wall resection is traditionally performed via open thoracotomy, a procedure that increases surgical morbidity and reduces postoperative quality of life. Conversely, thoracoscopic chest wall resection may minimize invasiveness but the optimal procedure remains uncertain. We previously reported rib resection using a pneumatic high-speed power drill during video-assisted thoracoscopic surgery for selected lung cancer patients. In this report, we present two cases of chest wall tumor resected using the drill via the thoracoscopic approach. We also report thoracoscopic chest wall reconstruction in one patient using a patch sheet.

    DOI: 10.1111/ases.12691

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  • Association between values of preoperative 6-min walk test and surgical outcomes in lung cancer patients with decreased predicted postoperative pulmonary function. Reviewed

    Tatsuo Nakagawa, Yasuaki Tomioka, Toshiya Toyazaki, Masashi Gotoh

    General thoracic and cardiovascular surgery   66 ( 4 )   220 - 224   2018.4

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    OBJECTIVE: We retrospectively investigated the possibility that the 6-min walk test (6MWT) could predict surgical outcomes in lung cancer patients with decreased predicted postoperative (ppo) lung function. METHODS: Patients were enrolled based on their preoperative spirometry: <60% of the ppo forced expiratory volume in 1 s (FEV1.0) or < 60% of the ppo lung carbon monoxide diffusion capacity (DLco). Morbidity, oxygen inhalation required > 10 days, home oxygen therapy (HOT) requirement, unexpected readmission within 90 days, and 90-day mortality were included as surgical outcomes. The correlations with walking distance and the minimum SpO2 (SpO2min) and maximum decrease in SpO2 (ΔSpO2) during the 6MWT were analyzed using logistic regression analysis, adjusting for age, sex, and surgical procedure. RESULTS: Altogether, 121 patients were analyzed. Logistic regression analysis revealed that higher ΔSpO2 and lower SpO2min were significantly correlated with a higher risk of prolonged need for oxygen inhalation and HOT, surgical morbidity, and 90-day mortality. Cut-off values of > 4% for ΔSpO2 were significant for prolonged oxygen inhalation and surgical morbidity. Cut-off values of < 89-91% for SpO2min were also significant for the need for prolonged oxygen inhalation, surgical morbidity, and HOT requirement. There were no significant correlations between walking distance and each surgical outcome. CONCLUSIONS: Oxygen desaturation during 6MWT was a good predictor for poor surgical outcomes in lung cancer patients with decreased ppo pulmonary function.

    DOI: 10.1007/s11748-018-0888-z

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  • Clinical Experience of Thoracoscopic Sleeve Lobectomy Using a Novel Needle Holder Reviewed

    Yasuaki Tomioka

    Seminars in Thoracic and Cardiovascular Surgery   2018

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    DOI: 10.1053/J.SEMTCVS.2018.07.001

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  • Thoracoscopic partial resection without using a stapler. (complete republication). Reviewed

    Toshiya Toyazaki, Yasuaki Tomioka, Naohisa Chiba, Yuichiro Ueda, Yasuto Sakaguchi, Masashi Gotoh, Shinya Ishikawa, Tatsuo Nakagawa

    General thoracic and cardiovascular surgery   65 ( 8 )   449 - 454   2017.8

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    Thoracoscopic partial pulmonary resection for small peripheral nodules without using a stapler has been introduced to our hospital. After partial resection was performed with electrocautery, two different methods of surface sealing were used: a coagulation method (C method) with Soft Coagulation alone, and a coagulation-suturing method (CS method) with Soft Coagulation combined with continuous suturing. The clinical outcomes of the two methods were retrospectively compared in this study. The C method was used in 19 lesions of 18 cases, and the CS method was used in 20 lesions of 19 cases. Primary lung cancer was the most frequent diagnosis (22 lesions of 21 cases). There were no differences between the two groups in the size and depth of the lesions. Operative time was longer with the CS method than with the C method. Postoperative air leakage was a complication in 4 cases with the C method, and one of them required re-do surgery, whereas only one case with the CS method had temporary air leakage. Postoperative computed tomography showed cavitation in 3 C method cases and 5 CS method cases, all without related symptoms. There were no local recurrences at resected sites. In conclusion, the C method was technically easy to perform, but air leakage may be prolonged after surgery. The CS method may have the advantage of causing less air leakage than the C method, but mastering the technique is important to shorten operative time.

    DOI: 10.1007/s11748-017-0784-y

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  • Clinical Experience of Rib Resection for Lung Cancer with Chest Wall Invasion Using a Pneumatic High Speed Power Drill System

    Yasuaki Tomioka

    Journal of Thoracic Oncology   2017

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    DOI: 10.1016/J.JTHO.2016.11.1028

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  • Thoracoscopic Partial Resection for Peripheral Pulmonary Nodules without Using Stapler

    Yasuaki Tomioka

    Journal of Thoracic Oncology   2017

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    DOI: 10.1016/J.JTHO.2016.11.1020

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MISC

  • MA08.09 Predictive CT Features of Visceral Pleural Invasion in Lung Cancer with Ground Glass Opacity

    N. Hayashi, K. Suzawa, K. Okada, T. Ryuko, Y. Tomioka, S. Tanaka, K. Miyoshi, K. Shien, M. Okazaki, S. Sugimoto, S. Toyooka

    Journal of Thoracic Oncology   2024.10

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    DOI: 10.1016/j.jtho.2024.09.154

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  • 【呼吸器の胸部外傷】肋骨・胸骨固定の現在 肋骨固定術を施行した胸部外傷70例の検討 適応と施術の実際的工夫 Reviewed

    富岡 泰章, 真鍋 建太, 山田 英司, 室 雅彦

    胸部外科   77 ( 4 )   272 - 277   2024.4

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publisher:(株)南江堂  

    肋骨固定器具を用いて胸腔鏡補助下に肋骨固定術を行った外傷性肋骨骨折70(男性47名、女性23名)例の治療適応基準と治療成績を報告した。対象は高齢患者が多く、受傷機転は転落・転倒や交通外傷が多かった。手術適応基準はフレイルチェスト9例、鎮痛・胸郭変形改善51例、肺損傷部修復10例で、使用した肋骨固定器具はKANI 66例、MatrixRIB 1例、KANIとMatrixRIBの併用2例、結紮+肋骨ピン1例であった。術後合併症は肺塞栓症と呼吸器感染症が各1例で、KANI使用例にプレート逸脱6例とプレート関連の疼痛1例を認めたが、プレートを抜去せずに経過観察しており、転帰はリハビリテーション目的の転院が46例、自宅退院が24例であった。肋骨固定術と胸腔鏡補助下手術を組み合わせることで効果的な肋骨固定や、手術創の大きさと筋肉損傷の低減が可能となるため、積極的に導入すべきである。

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J00349&link_issn=&doc_id=20240416070011&doc_link_id=issn%3D0021-5252%26volume%3D77%26issue%3D4%26spage%3D272&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0021-5252%26volume%3D77%26issue%3D4%26spage%3D272&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

  • 当科にて心膜開窓術を施行した9例の臨床因子と特徴についての検討

    山田 英司, 成本 耕平, 早間 洋平, 富岡 泰章, 室 雅彦

    日本呼吸器外科学会雑誌   38 ( 3 )   MO64 - 4   2024.4

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  • 急性膿胸を合併したMET陽性進行肺癌に対して膿瘍腔掻破術後に化学療法を継続し長期生存を示した1例

    早間 洋平, 山田 英司, 成本 耕平, 富岡 泰章, 室 雅彦

    日本呼吸器外科学会雑誌   38 ( 3 )   MO53 - 3   2024.4

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  • 腎細胞癌多発肺転移に対するICI治療後のOligoprogession病変切除により長期無再発生存を示した1例

    成本 耕平, 室 雅彦, 山田 英司, 富岡 泰章, 早間 洋平

    日本呼吸器外科学会雑誌   38 ( 3 )   MO48 - 1   2024.4

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  • cStageI期肺腺癌のEGFR検査結果に基づく予後に関する多施設共同後ろ向き観察研究(CReGYT-01 EGFR study)

    福田 祥大, 濱田 顕, 須田 健一, 小原 秀太, 高森 信吉, 木下 郁彦, 遠藤 誠, 富岡 泰章, 高森 聡, 野村 幸太郎, 藤野 孝介, 吉川 真生, 諏澤 憲, 枝園 和彦, 下川 元継, 宗 淳一, 津谷 康大

    日本呼吸器外科学会雑誌   38 ( 3 )   O61 - 2   2024.4

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  • EGFR遺伝子変異陽性pStage IA2-IA3期肺腺癌の予後解析 全国多施設後ろ向き観察研究(CReGYT-01 EGFR study)

    長野 太智, 高森 信吉, 木下 郁彦, 遠藤 誠, 濱田 顕, 小原 秀太, 福田 祥大, 富岡 泰章, 高森 聡, 野村 幸太郎, 藤野 孝介, 吉川 真生, 諏澤 憲, 枝園 和彦, 須田 健一, 下川 元継, 竹中 朋祐, 吉住 朋晴

    日本呼吸器外科学会雑誌   38 ( 3 )   O14 - 2   2024.4

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  • 小児肺移植の成果と課題

    杉本誠一郎, 柳光剛志, 富岡泰章, 田中真, 諏澤憲, 枝園和彦, 三好健太郎, 岡崎幹生, 豊岡伸一

    日本胸部外科学会定期学術集会(Web)   77th   2024

  • 心臓死ドナーからの肺・肝・腎の移植を企図したPulmoabdominal Normothermic Regional Perfusionによる新たな摘出前臓器保護評価法の開発

    田中真, 梅田将志, 柳光剛志, 富岡泰章, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本胸部外科学会定期学術集会(Web)   77th   2024

  • 岡山大学脳死肺移植例におけるドナー因子と短・長期アウトカム

    三好健太郎, 田中真, 杉本誠一郎, 調枝治樹, 松原慧, 富岡泰章, 塩谷俊雄, 橋本好平, 黒崎毅史, 大谷真二, 岡崎幹夫, 山根正修, 豊岡伸一

    日本胸部外科学会定期学術集会(Web)   76th   2023

  • DQ-DSA陽性生体肺移植レシピエントに対する両側脳死再肺移植

    三好健太郎, 調枝治樹, 富岡泰章, 石原恵, 田中真, 杉本誠一郎, 山根正修, 久保友次郎, 川名伸一, 清水大, 松原慧, 橋本好平, 岡崎幹生, 豊岡伸一

    日本移植学会総会プログラム抄録集   59th (Web)   2023

  • Identification of Single-Nucleotide Polymorphisms Associated with Renal Dysfunction After Lung Transplantation Using Ethnic-Specific SNP Array

    Y. Tomioka, S. Sugimoto, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, S. Tanaka, K. Miyoshi, M. Okazaki, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   S254 - S255   2022.4

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    DOI: 10.1016/j.healun.2022.01.623

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  • 生体肺移植のオプションがない再肺移植待機中の男児に対して長期的な肺移植までのブリッジとしての使用も視野に入れたV-V ECMOの導入経験

    富岡泰章, 三好健太郎, 田中真, 杉本誠一郎, 伊賀徳周, 金井理恵, 二階哲朗, 豊岡伸一, 山根正修

    日本移植学会総会プログラム抄録集   58th (Web)   2022

  • 60歳以上の高齢肺移植レシピエントにおける傾向スコアマッチングを用いた術後長期成績に関する検討

    久保友次郎, 田中真, 氏家裕征, 川名伸一, 清水大, 松原慧, 富岡泰章, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本移植学会総会プログラム抄録集   58th (Web)   2022

  • 中四国の非移植施設との連携による肺メディカルコンサルタント互助の取り組み

    杉本誠一郎, 松原慧, 清水大, 橋本好平, 田中真, 三好健太郎, 石原恵, 富岡泰章, 塩谷俊雄, 鹿谷芳伸, 山根正修, 青江基, 豊岡伸一

    日本移植学会総会プログラム抄録集   58th (Web)   2022

  • ジャポニカアレイNEOを用いた肺移植後の慢性腎臓病に関連する一塩基多型の同定

    富岡泰章, 杉本誠一郎, 川名伸一, 久保友次郎, 清水大, 松原慧, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • 当院での様々な開胸アプローチの経験

    田中 真, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   572 - 572   2021.10

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  • OSNA法を用いた肺がん所属リンパ節転移診断の臨床有用性の検討

    諏澤 憲, 難波 圭, 枝園 和彦, 三浦 章博, 荒木 恒太, 宮内 俊策, 中田 憲太郎, 富岡 泰章, 田中 真, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   666 - 666   2021.10

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  • 血漿Histidine-rich glycoprotein濃度と肺移植後一時移植機能不全との関係

    塩谷 俊雄, 杉本 誠一郎, 富岡 泰章, 田中 真, 諏澤 憲, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LOD17 - 1   2021.10

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  • OSNA法を用いた肺がん所属リンパ節転移診断の臨床有用性の検討

    諏澤 憲, 難波 圭, 枝園 和彦, 三浦 章博, 荒木 恒太, 宮内 俊策, 中田 憲太郎, 富岡 泰章, 田中 真, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   666 - 666   2021.10

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  • 片肺移植における二次性肺高血圧の影響 当院の片側脳死肺移植症例の検討から

    清水 大, 三好 健太郎, 杉本 誠一郎, 久保 友次郎, 川名 伸一, 富岡 泰章, 松原 慧, 田中 真, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LOP15 - 2   2021.10

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  • 綿密な術前準備を行った低肺機能患者の両側続発性高度気胸の1手術例

    土生 智大, 諏澤 憲, 坂田 龍平, 久保 友次郎, 岩田 一馬, 松田 直樹, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LCPA2 - 1   2021.10

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  • 肺移植後の慢性期合併症とその管理 肺移植後の慢性腎臓病に対して血液透析を導入した症例の検討

    富岡 泰章, 杉本 誠一郎, 川名 伸一, 久保 友次郎, 清水 大, 松原 慧, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正, 豊岡 伸一

    移植   56 ( 総会臨時 )   SWS8 - 4   2021.9

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  • 生体肺移植後CLADにおける2019年ISHLT新基準にもとづく予後評価

    松原 慧, 三好 健太郎, 大谷 真二, 川名 伸一, 久保 友次郎, 清水 大, 富岡 泰章, 田中 真, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   O23 - 1   2021.9

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  • 肺移植におけるドナー不足にどう取組むか 心停止ドナー肺移植、スペインでの経験を踏まえて

    田中 真, 石上 恵美, 石原 恵, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY9 - 4   2021.9

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  • 肺移植に関連した感染症(待機中から術後慢性期まで) Clostridioides difficile感染症診療ガイドライン作成に伴う当院での肺移植周術期の検討

    久保 友次郎, 田中 真, 石上 恵美, 石原 恵, 坂田 龍平, 富岡 泰章, 枝園 和彦, 諏澤 憲, 大谷 真二, 山本 寛斉, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY4 - 4   2021.9

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  • 肺移植に関連した感染症(待機中から術後慢性期まで) びまん性汎細気管支炎に対する肺移植後の慢性期管理と長期成績

    杉本 誠一郎, 三好 健太郎, 田中 真, 富岡 泰章, 石原 恵, 石上 恵美, 諏澤 憲, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY4 - 5   2021.9

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  • 肺移植における多職種連携 新型コロナウイルス感染症(COVID-19)流行下での肺移植後患者フォローの工夫と課題

    石原 恵, 杉本 誠一郎, 石上 恵美, 鶴園 真理, 山下 里美, 難波 由美子, 富岡 泰章, 田中 真, 三好 健太郎, 大谷 真二, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SWS3 - 2   2021.9

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  • 肺移植後の慢性期合併症とその管理 肺移植後の慢性腎臓病に対して血液透析を導入した症例の検討

    富岡 泰章, 杉本 誠一郎, 川名 伸一, 久保 友次郎, 清水 大, 松原 慧, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正, 豊岡 伸一

    移植   56 ( 総会臨時 )   SWS8 - 4   2021.9

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  • 生体肺移植後CLADにおける2019年ISHLT新基準にもとづく予後評価

    松原 慧, 三好 健太郎, 大谷 真二, 川名 伸一, 久保 友次郎, 清水 大, 富岡 泰章, 田中 真, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   O23 - 1   2021.9

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  • 肺移植後成績の芳しくないレシピエント群-乳幼児肺移植

    大谷 真二, 石原 恵, 石上 恵美, 松原 慧, 清水 大, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   76 - 76   2021.7

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  • シャント造設を契機に片側肺の肺水腫及び肺高血圧を来した両側生体肺移植後CLADの一例

    清水 大, 三好 健太郎, 東馬 智子, 松田 裕介, 松原 慧, 富岡 泰章, 塩谷 俊雄, 山本 治慎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   104 - 104   2021.7

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  • 脊柱側彎症患者に対する脳死両肺移植、術後合併症の経験

    山本 治慎, 大谷 真二, 清水 大, 松原 慧, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   102 - 102   2021.7

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  • BKウイルス感染症による出血性膀胱炎で周術期治療に難渋した小児生体肺移植の1例

    富岡 泰章, 大谷 真二, 石上 恵美, 石原 恵, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   100 - 100   2021.7

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  • 肺移植患者の周術期におけるClostridioides difficile感染症の検討

    坂田 龍平, 大谷 真二, 石上 恵美, 石原 恵, 土生 智大, 岩田 一馬, 久保 友次郎, 松田 直樹, 清水 大, 松原 慧, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O18 - 4   2021.5

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  • Pediatric Lung Transplantation−Intermediate Outcomes of a Japanese Center

    S. Otani, Y. Tomioka, K. Matsubara, D. Shimizu, H. Yamamoto, T. Shiotani, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.995

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  • Post-Transplant Lymphoproliferative Disorder in Lung Transplantation: A Single-Center Experience in Japan

    D. Shimizu, S. Otani, Y. Tomioka, T. Shiotani, H. Yamamoto, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.884

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  • Risk Assessment of Chronic Lung Allograft Dysfunction Phenotypes after Living-Donor Lobar Lung Transplantation According to the 2019 ISHLT Classification System

    K. Matsubara, S. Otani, D. Shimizu, Y. Tomioka, T. Shiotani, H. Yamamoto, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.867

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  • The UNCX Polymorphism is Associated with the Development of Renal Dysfunction after Lung Transplantation

    Y. Tomioka, S. Sugimoto, K. Matsubara, D. Shimizu, H. Yamamoto, T. Shiotani, K. Miyoshi, S. Ohtani, M. Okazaki, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   S346 - S347   2021.4

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    DOI: 10.1016/j.healun.2021.01.977

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  • Combination of Neutrophil to Lymphocyte Ratio and Glasgow Prognostic Score Improves Prognostic Accuracy in Lung Transplantation: Validation of 9 Preoperative Prognostic Scoring Methods

    H. Yamamoto, S. Sugimoto, E. Suzuki, Y. Tomioka, T. Shiotani, D. Shimizu, K. Matsubara, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.1007

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  • 当院における小児肺移植の成績

    大谷 真二, 富岡 泰章, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本外科学会定期学術集会抄録集   121回   PS - 8   2021.4

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  • Plasma Levels of Histidine-Rich Glycoprotein are Associated with the Development of Primary Graft Dysfunction after Lung Transplantation

    T. Shiotani, S. Sugimoto, H. Yamamoto, K. Matsubara, D. Shimizu, K. Nakata, Y. Tomioka, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.455

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  • 脳死片肺移植を施行した多中心性キャッスルマン病の1例

    富岡 泰章, 大谷 真二, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   506 - 506   2021.3

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  • 当院における高齢者レシピエント症例の検討

    富岡 泰章, 大谷 真二, 清水 大, 松原 慧, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   253 - 253   2020.10

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  • 肺移植におけるLiquid biopsy ドナー由来血中遊離DNAとマイクロRNA

    杉本 誠一郎, 塩谷 俊雄, 富岡 泰章, 石上 恵美, 石原 恵, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   242 - 242   2020.10

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  • 肉腫多発肺転移手術症例における末梢血好中球/リンパ球比(NLR)の予後予測因子としての意義

    山本 寛斉, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LOO2 - 2   2020.10

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  • 間質性肺炎合併肺癌の予後における末梢血好中球/リンパ球比(NLR)の影響

    松原 慧, 山本 寛斉, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LOO1 - 54   2020.10

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  • 肺移植における抗HLA抗体と抗体関連拒絶反応 抗胸腺細胞グロブリンをfirst lineとした肺移植後急性期抗体関連拒絶反応の治療成績

    三好 健太郎, 大谷 真二, 杉本 誠一郎, 富岡 泰章, 塩谷 俊雄, 黒崎 毅史, 諏澤 憲, 山本 寛斎, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LWS1 - 1   2020.10

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  • ロボット支援手術におけるリンパ節郭清手技 VATS、単孔式VATSと比較して

    岡崎 幹生, 諏澤 憲, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LRS1 - 3   2020.10

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  • 非小細胞肺癌手術症例と末梢血リンパ球/単球比とその継時的変化の関連の検討

    富岡 泰章, 山本 寛斉, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   587 - 587   2020.10

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  • CTガイド下生検では診断困難であった肺門部結節影

    松原 慧, 大谷 真二, 高津 史明, 富岡 泰章, 津高 慎平, 山本 治慎, 塩谷 俊雄, 難波 圭, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹雄, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    岡山医学会雑誌   132 ( 1 )   46 - 46   2020.4

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  • The case of an anomalous systemic arterial supply to a normal basal segment of the lung surgically treated with dissection using a stapler

    福井崇将, 富岡泰章, 宮本英, 大角潔, 後藤正司, 中川達雄

    日本呼吸器外科学会雑誌(Web)   34 ( 5 )   2020

  • 当院における高齢者レシピエント症例の検討

    富岡 泰章, 大谷 真二, 清水 大, 松原 慧, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( Supplement )   253_1 - 253_1   2020

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    【背景】日本における高齢者レシピエントの長期成績に関しての報告は少ない.今回当院における高齢者レシピエントの長期成績について後方視的に検討した.【対象と方法】1998年1月~2020年1月に施行した18歳以上の肺移植症例161例を対象とした.60歳以上の高齢群(H群:n=10)と18-59歳の非高齢群(L群:n=151)の2群に分けて,全生存期間(OS)およびCLAD発症までの期間(CFS)について解析を行った.【結果】H群ではL群と比較して片肺移植(p=0.03),間質性肺炎(p=0.02),男性(p=0.04)の割合が有意に多かった.BMI,ドナー年齢,総虚血時間,LASスコアには有意差は認めなかった.H群とL群の5年OSはそれぞれ51.9%と75.5%であり,有意差を認めた(p=0.02).H群とL群の5年CFSはそれぞれ53.3%と72.5%であった.サブグループ解析では,H群の片肺移植症例(5年:OS 25%)は両肺移植症例(5年OS:75%)と比較してOSが悪い傾向にあった(p=0.08)が,H群の両肺移植症例はL群の両肺移植症例(5年OS:74.2%)と比較しても同等の成績であった(p=0.5).【結語】60歳以上のレシピエントの成績は60歳未満と比較し不良だが,両肺移植がより望ましい可能性が示唆された.

    DOI: 10.11386/jst.55.supplement_253_1

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  • 肺移植におけるLiquid biopsy:ドナー由来血中遊離DNAとマイクロRNA

    杉本 誠一郎, 塩谷 俊雄, 富岡 泰章, 石上 恵美, 石原 恵, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   55 ( Supplement )   242_2 - 242_2   2020

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    【背景】低侵襲に血液や体液を採取し解析を行うLiquid biopsyは、癌領域では既に臨床応用され治療方針の決定に一役買っているが、移植領域ではまだ発展途上である。当科では肺移植におけるLiquid biopsyとして、ドナー由来血中遊離DNA(dd-cf-DNA)とマイクロRNA(miRNA)を標的にした研究を行ってきたため、その成果を報告する。【方法】ドナーとレシピエントの一塩基多型を比較してdd-cf-DNAを測定し、生体肺移植後の急性拒絶反応(AR)における診断的意義を検討した。次にレシピエントのみの検体で評価できるmiRNAを測定し、脳死・生体肺移植後の移植片慢性機能不全(CLAD)における診断的意義を検討した。【結果】dd-cf-DNAは、感染群(p=0.028)や安定群(p=0.001)よりAR群で有意に増加しており、生体肺移植後ARの診断に有用であった(Sci Rep 2018)。また線維化に関与するmiRNAが、非CLAD群よりCLAD群で有意に増加しており(p=0.008)、一秒量の変化率とも相関し(p=0.014)、CLAD診断に有用であった。【結論】肺移植のLiquid biopsy として、dd-cf-DNAは生体肺移植後ARの診断に、またmiRNAはCLADの診断に有用である。今後の臨床応用を目指して症例数の集積と簡便で精度の高い方法の開発が望まれる。

    DOI: 10.11386/jst.55.supplement_242_2

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  • 肺癌との鑑別が困難であった肺結節性リンパ過形成の1例

    富岡 泰章, 山本 寛斉, 松原 慧, 山本 治慎, 塩谷 俊雄, 難波 圭, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   878 - 878   2019.11

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  • 定型カルチノイドを伴うびまん性特発性肺神経内分泌過形成の1例

    富岡 泰章, 山本 寛斉, 松原 慧, 山本 治慎, 塩谷 俊雄, 難波 圭, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   878 - 878   2019.11

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  • A case of benign emptying of the postpnenumonectomy space after left pneumonectomy for lung cancer

    千葉直久, 富岡泰章, 戸矢崎利也, 上田雄一郎, 後藤正司, 中川達雄

    日本呼吸器外科学会雑誌(Web)   32 ( 2 )   2018

  • A case of resected pulmonary carcinosarcoma requiring the differential diagnosis of a solitary fibrous tumor

    上田雄一郎, 中川達雄, 富岡泰章, 戸矢崎利也, 後藤正司

    日本呼吸器外科学会雑誌(Web)   32 ( 2 )   2018

  • A case of chest wall tumor resection with thoracoscopic assistance using a pneumatic high-speed power drill

    富岡泰章, 戸矢崎利也, 千葉直久, 上田雄一郎, 後藤正司, 中川達雄

    日本呼吸器外科学会雑誌(Web)   31 ( 4 )   2017

  • 左肺上舌区域間に明瞭な過分葉を伴う肺癌に対し区域切除を施行した2例

    千葉直久, 富岡泰章, 戸矢崎利也, 上田雄一郎, 後藤正司, 中川達雄

    日本呼吸器外科学会雑誌(Web)   30 ( 7 )   2016

  • 術前・術中診断が困難であった肝類上皮性血管内皮腫の一例

    富岡泰章, 児玉英謙, 嶋健太郎, 大原勝人, 初貝和明, 市川宏文, 赤羽武弘, 高橋徹, 金田巖

    日本消化器外科学会雑誌(Web)   46 ( Supplement1 )   2013

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Research Projects

  • ナノポアシーケンサーを用いた移植肺障害の革新的な迅速診断法の開発と病態解明

    Grant number:23KK0154  2023.09 - 2027.03

    日本学術振興会  科学研究費助成事業  国際共同研究加速基金(海外連携研究)

    杉本 誠一郎, 大谷 真二, 橋本 好平, 三好 健太郎, 富岡泰章

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    Grant amount:\20930000 ( Direct expense: \16100000 、 Indirect expense:\4830000 )

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  • Identification of genetic loci associated with chronic lung allograft dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array

    Grant number:23K08294  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    富岡 泰章, 冨田 秀太, 豊岡 伸一, 杉本 誠一郎

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

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