記述言語：英語   掲載種別：研究論文（学術雑誌）  

Lacosamide is a third-generation antiepileptic drug that selectively promotes the slow inactivation of sodium channels. Herein, we report a case of fatal lacosamide poisoning following an autopsy. A female in her fifties was found dead in her living room. She had been diagnosed with epilepsy and had been prescribed lacosamide, carbamazepine, lamotrigine, and perampanel. At the scene, empty blister packs containing a total of 4950 mg of lacosamide were found in her bag. Additionally, two tablets of a commercially available sleeping medication containing diphenhydramine were missing. A medicolegal autopsy was conducted two days later. The stomach contained 120 mL of a slightly viscid fluid, which appeared powdery and suspended. Qualitative analysis using gas chromatography-mass spectrometry detected lacosamide, carbamazepine, and lamotrigine, while perampanel and diphenhydramine were not found. The blood lacosamide concentration was 70.1-86.8 µg/mL. These values were higher than the current reference range of lacosamide and comparable to or higher than those of previous fatal cases. Carbamazepine and lamotrigine levels were within or below the therapeutic range. Based on these findings, we determined that the cause of her death was lacosamide poisoning.

DOI： 10.1016/j.legalmed.2025.102658

PubMed

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担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

It is reported that immunostaining of Myoglobin (Mb) is useful for forensic diagnosis. In this study, we investigated the condition of fixation of striated muscle in 10 % neutral-buffered formalin to obtain appropriate stationarity of Mb in immunostaining. Firstly, criteria for staining intensity and definition of the stainability of examined were determined for sheep muscle tissue. Sheep myocardial tissue was fixed using 10 % neutral-buffered formalin under the 21 different conditions based on combinations of the following: three ratios of volume of formalin (mL) to weight of myocardium (g) (RFM) of 1, 4 or 9, 7 durations of fixation (DF) of 0.5, 3 or 6 h, and 1, 2, 5 or 7 days. Secondly, detection of Mb diffused form skeletal muscle from autopsy cases into formalin during fixation were confirmed by ELISA. Finally, the evaluation of stainability of Mb of striated muscle in routine autopsy examinations was confirmed using sheep staining intensity standards. From this experimental investigation, it has been demonstrated that the most suitable formalin fixation condition for using Mb staining in forensic diagnosis is RFM4 with a fixation time of at least DF 3 h up to 1 day. It was evident that staining intensity decreases with fixation durations exceeding 2 days, irrespective of the RFM. Thus, the fixation time was deemed the most influential factor affecting the staining properties of Mb staining in skeletal muscle tissue. When conducting Mb staining using striated muscle as an evaluation sample, particular attention should be paid to the fixation time.

DOI： 10.1016/j.legalmed.2024.102496

PubMed

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担当区分：筆頭著者   記述言語：日本語   出版者・発行元：日本法医病理学会  

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記述言語：日本語   出版者・発行元：岡山医学会  

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00175&link_issn=&doc_id=20220808080008&doc_link_id=10.4044%2Fjoma.134.108&url=https%3A%2F%2Fdoi.org%2F10.4044%2Fjoma.134.108&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

記述言語：日本語   出版者・発行元：日本法医病理学会  

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開催年月日： 2023年

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開催年月日： 2020年12月

記述言語：日本語  

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開催年月日： 2020年8月

記述言語：日本語  

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開催年月日： 2020年8月

記述言語：日本語  

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開催年月日： 2020年8月

記述言語：日本語  

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