2021/04/08 更新

写真a

マツウラ エイジ
松浦 栄次
MATSUURA Eiji
所属
中性子医療研究センター 教授
職名
教授
外部リンク

学位

  • 修士(薬学) ( 岡山大学 )

  • 博士(医学) ( 岡山大学 )

研究キーワード

  • 脂質代謝学

  • 生化学

  • 分子イメージング学

  • 腫瘍生物学

  • 臨床診断学

  • 免疫学

研究分野

  • ライフサイエンス / 膠原病、アレルギー内科学

  • その他 / その他  / 病態検査学

  • ライフサイエンス / 代謝、内分泌学

  • ライフサイエンス / 免疫学

  • ライフサイエンス / 病態医化学

  • ライフサイエンス / 放射線科学

▼全件表示

学歴

  • 岡山大学   Graduate School, Division of Pharmaceutical Sciences  

    - 1984年

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経歴

  • 岡山大学中性子医療研究センター 教授   Neutron Therapy Research Center

    2017年4月 - 現在

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  • - Professor,Neutron Medical Research Center,Okayama University

    2017年

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  • 岡山大学大学院医歯薬学総合研究科産学官連携センター 教授   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

    2011年1月 - 現在

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  • 岡山大学医歯薬学総合研究科病態制御科学専攻病態機構学講座(細胞化学分野)准教授

    2007年4月 - 2011年1月

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  • Associate Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2007年 - 2011年

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  • 岡山大学大学医学部附属分子細胞医学研究施設 細胞工学部門 助教授

    2001年4月 - 2007年3月

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  • 岡山大学医学部附属分子細胞医学研究施設細胞工学部門 講師

    1997年5月 - 2001年3月

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  • 北海道大学医学部生化学第一講座 助手

    1995年11月 - 1997年4月

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  • ヤマサ醤油(株)診断薬部免疫研究室 主任研究員

    1988年11月 - 1995年10月

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  • Department of Pediatrics and Medicine, National Jewish Center for Immunology and Respiratory Medicine (affiliated to Colorado University Health Science Center), Denver, CO, USA, Research Associate

    1986年9月 - 1988年11月

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  • 岡山大学薬学部 助手   Faculty of Pharmaceutical Sciences

    1985年4月 - 1986年8月

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所属学協会

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論文

  • Identification and visualization of oxidized lipids in atherosclerotic plaques by microscopic imaging mass spectrometry-based metabolomics 査読

    Lianhua Shen, Takushi Yamamoto, Xian Wen Tan, Koretsugu Ogata, Eiji Ando, Eiichi Ozeki, Eiji Matsuura

    Atherosclerosis   2020年8月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.atherosclerosis.2020.08.001

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  • Rapid and specific detection of oxidized LDL/β2GPI complexes via facile lateral flow immunoassay 査読

    Xian Wen Tan, Fumiaki Takenaka, Hironori Takekawa, Eiji Matsuura

    Heliyon6 ( 6 ) e04114 - e04114   2020年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.heliyon.2020.e04114

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  • Tithonia diversifolia ‐derived orizabin suppresses cell adhesion, differentiation, and oxidized LDL accumulation by Akt signaling suppression via PTEN promotion in THP‐1 cells 査読

    Masahiro Ide, Izumi Yoshida, Momochika Kumagai, Takashi Mishima, Yushi Takahashi, Kazuhiro Fujita, Tomoji Igarashi, Eiji Matsuura

    Journal of Food Biochemistry   2020年5月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/jfbc.13268

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jfbc.13268

  • Sera anti-P53 antibody provides new information which explains the link between diabetes and cancer 査読

    Sauriasari R, Sekar AP Andisyah N, Syahdi RR, Matsuura E

    Diabetes Metab Syndr Obes11 ( 13 ) 325 - 331   2020年2月

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    担当区分:責任著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Novel single‐chain variant of antibody against mesothelin established by phage library 査読

    Hiromasa Yakushiji, Kazuko Kobayashi, Fumiaki Takenaka, Yoshiro Kishi, Midori Shinohara, Masaru Akehi, Takanori Sasaki, Eiji Ohno, Eiji Matsuura

    Cancer Science110 ( 9 ) 2722 - 2733   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/cas.14150

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/cas.14150

  • Mutants of β2-glycoprotein I: their features and potent applications 査読

    Lianhua Shen, Nuriza Ulul Azmi, Xian Wen Tan, Shinsuke Yasuda, Arum Tri Wahyuningsih, Junko Inagaki, Kazuko Kobayashi, Eiji Ando, Takanori Sasaki, Eiji Matsuura

    Best Practice & Research: Clinical Rheumatology32 ( 4 ) 856 - 862   2018年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome. 査読

    Ames PRJ, Lopez LL, Merashli M, Matsuura E

    Autoimmun Highlights9   2   2018年

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  • 89Zr標識ヒト抗体バリアントと新規DDSキャリアによるTheranostics技術 招待

    竹中文章, 小林和子, 木村俊作, 小関英一, 大槻, 小渕浩嗣, 松浦栄次

    Drug Delivery System33   214 - 222   2018年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Anti-high Mobility Group Box 1 Antibody Ameliorates Albuminuria in MRL/lpr Lupus-Prone Mice 査読

    Haruki Watanabe, Katsue S. Watanabe, Keyue Liu, Sumie Hiramatsu, Sonia Zeggar, Eri Katsuyama, Noriko Tatebe, Akiya Akahoshi, Fumiaki Takenaka, Takahisa Hanada, Masaru Akehi, Takanori Sasaki, Ken-ei Sada, Eiji Matsuura, Masahiro Nishibori, Jun Wada

    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT6   31 - 39   2017年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CELL PRESS  

    We evaluated the efficacy of a neutralizing anti-high mobility group box 1 (HMGB1) monoclonal antibody in MRL/lpr lupus-prone mice. The anti-HMGB1 monoclonal antibody (5 mg/kg weight) or class-matched control immunoglobulin G2a (IgG2a) was administered intravenously twice a week for 4-15 weeks. Urine albumin was monitored, and histological evaluation of the kidneys was conducted at 16 weeks. Lymphadenopathies were evaluated by 1-(2'-deoxy-2'-[F-18]fluoro-beta-D-arabinofuranosyl) cytosine ([F-18] FAC) positron emission tomography/computed tomography (PET/CT) at 12 weeks. Following 4-week treatment, [F-18]FAC-PET/CT showed similar accumulation in cervical and axillary lymph nodes at 12 weeks of age. However, anti-HMGB1 monoclonal antibody sufficiently inhibited the increase in albuminuria compared to an isotype control following 15-week treatment. Complement deposition was also improved; however, there were no significant differences in IgG deposition and renal pathological scores between the two groups. Anti-double-stranded DNA (dsDNA) antibody titers and cytokine and chemokine levels were also unaltered. Although there were no significant differences in glomerular macrophage infiltration, neutrophil infiltration was significantly decreased by the anti-HMGB1 monoclonal antibody. Antagonizing HMGB1 treatment suppressed HMGB1 translocation from nuclei in the kidney and suppressed neutrophil extracellular traps. The anti-HMGB1 monoclonal antibody demonstrated therapeutic potential against albuminuria in lupus nephritis by inhibiting neutrophil recruitment and neutrophil extracellular traps.

    DOI: 10.1016/j.omtm.2017.05.006

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  • The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPARγ

    Li J, Xiu Z, Wang R, Yu C, Chi Y, Qin J, Fu C, Matsuura E, Liu Q

    Life sciences. Pt. 2: Biochemistry, general and molecular biology177   27 - 40   2017年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.lfs.2017.03.024

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  • Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma

    Xiezhao Li, Peng Xu, Chongshan Wang, Naijin Xu, Abai Xu, Yawen Xu, Takuya Sadahira, Motoo Araki, Koichiro Wada, Eiji Matsuura, Masami Watanabe, Junxia Zheng, Pinghua Sun, Peng Huang, Yasutomo Nasu, Chunxiao Liu

    ONCOTARGET8 ( 13 ) 21177 - 21186   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IMPACT JOURNALS LLC  

    Renal cell carcinoma (RCC) management has undergone a major transformation over the past decade; immune checkpoint inhibitors are currently undergoing clinical trials and show promising results. However, the effectiveness of immune checkpoint inhibitors in patients with metastatic RCC (mRCC) is still limited. Lycorine, an alkaloid extracted from plants of the Amaryllidaceae family, is touted as a potential anti-cancer drug because of its demonstrative growth inhibition capacity (induction of cell cycle arrest and inhibition of vasculogenic mimicry formation). Moreover, T cell checkpoint blockade therapy with antibodies targeting cytotoxic T-lymphocyte associated protein 4 (CTLA-4) has improved outcomes in cancer patients. However, the anti-tumor efficacy of combined lycorine and anti-CTLA-4 therapy remains unknown. Thus, we investigated a combination therapy of lycorine hydrochloride and anti-CTLA-4 using a murine RCC model. As a means of in vitro confirmation, we found that lycorine hydrochloride inhibited the viability of various RCC cell lines. Furthermore, luciferase-expressing Renca cells were implanted in the left kidney and the lung of BALB/c mice to develop a RCC metastatic mouse model. Lycorine hydrochloride and anti-CTLA-4 synergistically decreased tumor weight, lung metastasis, and luciferin-staining in tumor images. Importantly, the observed anti-tumor effects of this combination were dependent on significantly suppressing regulatory T cells while upregulating effector T cells; a decrease in regulatory T cells by 31.43% but an increase in effector T cells by 31.59% were observed in the combination group compared with those in the control group). We suggest that a combination of lycorine hydrochloride and anti-CTLA-4 is a viable therapeutic option for RCC patients.

    DOI: 10.18632/oncotarget.15505

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  • In vivo distribution of single chain variable fragment (scFv) against atherothrombotic oxidized LDL/β2-glycoprotein I complexes into atherosclerotic plaques of WHHL rabbits: Implication for clinical PET imaging. 査読

    Sasaki T, Kobayashi K, Kita S, Kojima K, Hirano H, Shen L, Takenaka F, Kumon H, Matsuura E

    Autoimmun Rev16 ( 2 ) 159 - 167   2017年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.autrev.2016.12.007

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  • Real-time monitoring of tumor progression and drug responses in a preclinical mouse model of prostate cancer 査読

    Peng Xu, Naijin Xu, Kai Guo, Abai Xu, Fumiaki Takenaka, Eiji Matsuura, Chunxiao Liu, Hiromi Kumon, Peng Huang

    ONCOTARGET7 ( 22 ) 33025 - 33034   2016年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IMPACT JOURNALS LLC  

    Monitoring disease progression through imaging is playing an increasingly important role in the treatment of prostate cancer. Here, we report that primary mouse prostate cancer cell lines stably expressing luciferase and tumor biomarkers can be monitored through bioluminescence imaging along with assays of serum biomarkers and immune function. Tumorigenesis in immunocompetent C57BL/6 mice can be monitored in by collecting samples from the dorsal flank, dorsolateral prostate, and tail vein to obtain real-time subcutaneous, orthotopic, and metastasis indicators, respectively. We used this technique to confirm the therapeutic effect of immune checkpoint blockade. Our findings suggest the presented indicators are ideally suited for real-time tracking of drug responses, tumor progression and immune function.

    DOI: 10.18632/oncotarget.8846

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  • The function of β2-glycoprotein I in angiogenesis and its in vivo distribution in tumor xenografts 査読

    Arum Tri Wahyuningsih, Lianhua Shen, Kazuko Kobayashi, Takanori Sasaki, Fumiaki Takenaka, Takahisa Hanada, Masaru Akehi, Akiya Akahoshi, Eiichi Ozeki, Eiji Ando, Eiji Matsuura

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama70 ( 1 ) 13 - 24   2016年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Enhanced cellular uptake of lactosomes using cell-penetrating peptides 査読

    Akiya Akahoshi, Eiji Matsuura, Eiichi Ozeki, Hayato Matsui, Kazunori Watanabe, Takashi Ohtsuki

    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS17 ( 1 ) 245 - 252   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Polymeric micelles that are composed of synthetic polymers are generally size controllable and can be easily modified for various applications. Lactosomes (A(3)B-type) are biodegradable polymeric micelles composed of an amphipathic polymer, including three poly(sarcosine) blocks and a poly(L-lactic acid) block. Lactosomes accumulate in tumors in vivo through the enhanced permeability and retention (EPR) effect, even on frequently administering them. However, lactosomes cannot be efficiently internalized by cells. To improve cellular uptake of lactosomes, cell-penetrating peptide (CPP)-modified lactosomes were prepared. Seven CPPs (including EB1 and Pep1) were used, and most of them improved the cellular uptake efficiency of lactosomes. In particular, EB1- and Pep1-modified lactosomes were efficiently internalized by cells. In addition, by using CPP-modified and photosensitizer-loaded lactosomes, we demonstrated the photoinduced killing of mammalian cells, including human cancer cells. Accumulation of the EB1-modified lactosomes in NCI-N87 tumors was shown by in vivo imaging. Thus, this study demonstrated that the CPP-modified lactosome is a promising drug carrier.
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    DOI: 10.1080/14686996.2016.1178056

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  • Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes 査読

    Xian Wen Tan, Mrinal Bhave, Alan Yean Yip Fong, Eiji Matsuura, Kazuko Kobayashi, Lian Hua Shen, Siaw San Hwang

    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY2016   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI LTD  

    This study was aimed at preliminarily assessing the cytoprotective and antioxidative effects of rice bran extracts (RBEs) from a Sarawak local rice variety (local name: "BJLN") and a commercial rice variety, "MR219," on oxidative stress in rat H9c2(2-1) cardiomyocytes. The cardiomyocytes were incubated with different concentrations of RBE and hydrogen peroxide (H2O2), respectively, to identify their respective IC50 values and safe dose ranges. Two nonlethal and close-to-IC50 doses of RBE were selected to evaluate their respective effects on H2O2 induced oxidative stress in cardiomyocytes. Both RBEs showed dose-dependent cytotoxicity effects on cardiomyocytes. H2O2 induction of cardiomyocytes pretreated with RBE further revealed the dose-dependent cytoprotective and antioxidative effects of RBE via an increase in IC50 values of H2O2. Preliminary analyses of induction effects of RBE and H2O2 on cellular antioxidant enzyme, catalase (CAT), also revealed their potential in regulating these activities and expression profile of related gene on oxidative stress in cardiomyocytes. Pretreated cardiomyocytes significantly upregulated the enzymatic activity and expression level of CAT under the exposure of H2O2 induced oxidative stress. This preliminary study has demonstrated the potential antioxidant effects of RBE in alleviating H2O2-mediated oxidative injuries via upregulation in enzymatic activities and expression levels of CAT.

    DOI: 10.1155/2016/6943053

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  • A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model 査読

    Kai Guo, Peng Huang, Naijin Xu, Peng Xu, Haruki Kaku, Shaobo Zheng, Abai Xu, Eiji Matsuura, Chunxiao Liu, Hiromi Kumon

    ONCOTARGET6 ( 25 ) 21137 - 21147   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IMPACT JOURNALS LLC  

    YM155, a small molecule inhibitor of the antiapoptotic protein survivin, has been developed as a potential anti-cancer drug. We investigated a combination therapy of YM155 and interleukin-2 (IL-2) in a mouse model of renal cell carcinoma (RCC). YM155 caused cell cycle arrest and apoptosis in renal cancer (RENCA) cells. Next, luciferase-expressing RENCA cells were implanted in the left kidney and the lung of BALB/c mice to develop RCC metastatic model. In this orthotopic renal and metastatic lung tumors models, YM155 and IL-2 additively decreased tumor weight, lung metastasis, and luciferin-stained tumor images. Also, the combination significantly suppressed regulatory T cells and myeloid-derived suppressor cells compared with single agent treatment. We suggest that a combination of YM155 and IL-2 can be tested as a potential therapeutic modality in patients with RCC.

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  • Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan 査読

    Yoshiteru Tada, Kenji Yagi, Masaaki Uno, Nobuhisa Matsushita, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Shimada, Kyoko Nishi, Motohiro Hirasawa, Junichiro Satomi, Keiko T. Kitazato, Teruyoshi Kageji, Eiji Matsuura, Shinji Nagahiro

    JOURNAL OF STROKE & CEREBROVASCULAR DISEASES24 ( 7 ) 1487 - 1492   2015年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Background: Managing hypertension is crucial for preventing stroke recurrence. Some stroke patients experience resistant hypertension. In our experimental stroke model, olmesartan increased the expression of angiotensin (Ang) II converting enzyme-2. We hypothesized that switching to olmesartan affects biomarkers and the blood pressure (BP) in stroke patients whose BP is insufficiently controlled by standard doses of Ang II type I receptor blockers (ARBs) other than olmesartan. Methods: We recruited 25 patients to study our hypothesis. All had a history of stroke or silent cerebral infarction. We switched them to olmesartan (10-40 mg per day) for 12 weeks and determined their plasma level of Ang-(1-7), peroxiredoxin, oxidized low-density lipoprotein (oxLDL)/beta-2-glycoprotein I (beta 2GPI) complex, adiponectin, high mobility group box 1 (HMGB1), and tumor necrosis factor-alpha (TNF alpha) and recorded their BP before and after olmesartan treatment. Results: After switching the patients to olmesartan, their plasma level of Ang-(1-7) as a vasoprotective indicator and adiponectin regulating metabolic syndrome was increased, and peroxiredoxin and the oxLDL/beta 2GPI complex indicating its antioxidative stress and its proatherogenicity were lower than their baseline. This suggests that olmesartan may be more effective than other ARBs to improve these conditions. Neither HMGB1 nor TNF alpha reflecting an inflammatory response was affected, suggesting that the anti-inflammatory effects of olmesartan are similar to those of other ARBs. The recommended BP (<140/90) was obtained in 10 of the 25 patients after switching to olmesartan. No adverse events occurred. Conclusions: Switching from other ARBs to olmesartan may be a promising therapeutic option in patients with resistant hypertension.

    DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.015

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  • Positron Emission Tomography to Elucidate Pharmacokinetic Differences of Regioisomeric Retinoid X Receptor Agonists 査読

    Toshiki Kobayashi, Yuki Furusawa, Shoya Yamada, Masaru Akehi, Fumiaki Takenaka, Takanori Sasaki, Akiya Akahoshi, Takahisa Hanada, Eiji Matsuura, Hiroyuki Hirano, Akihiro Tai, Hiroki Kakuta

    ACS MEDICINAL CHEMISTRY LETTERS6 ( 3 ) 334 - 338   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER CHEMICAL SOC  

    RXR partial agonist NEt-41B (2a, 6-[ethyl-(4-isobutoxy-3-isopropylphenyl)amino]pyridine-3-carboxylic acid: EC50 = 169 nM, E-max = 55%) showed a blood concentration higher than its Emax after single oral administration at 30 mg/kg to mice, and repeated oral administration at 10 mg/kg/day to KK-A(y) mice afforded antitype 2 diabetes activity without the side effects caused by RXR full agonists. However, RXR full agonist NEt-3IB (la), in which the isobutoxy and isopropyl groups of 2a are interchanged, gave a much lower blood concentration than 2a. Here we used positron emission tomography (PET) with tracers [C-11] la, [C-11]2a and fluorinated derivatives [F-18] lb, [F-18]2b, which have longer half-lives, to examine the reason why la and 2a exhibited significantly different blood concentrations. As a result, the reason for the high blood concentration of 2a after oral administration was found to be linked to higher intestinal absorbability together with lower biliary excretion, compared with la.

    DOI: 10.1021/ml500511m

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  • A Novel PET Imaging Using Cu-64-Labeled Monoclonal Antibody against Mesothelin Commonly Expressed on Cancer Cells 査読

    Kazuko Kobayashi, Takanori Sasaki, Fumiaki Takenaka, Hiromasa Yakushiji, Yoshihiro Fujii, Yoshiro Kishi, Shoichi Kita, Lianhua Shen, Hiromi Kumon, Eiji Matsuura

    JOURNAL OF IMMUNOLOGY RESEARCH2015:268172. doi: 10.1155/2015   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI PUBLISHING CORPORATION  

    Mesothelin (MSLN) is a 40-kDa cell differentiation-associated glycoprotein appearing with carcinogenesis and is highly expressed in many human cancers, including the majority of pancreatic adenocarcinomas, ovarian cancers, and mesotheliomas, while its expression in normal tissue is limited to mesothelial cells lining the pleura, pericardium, and peritoneum. Clone 11-25 is a murine hybridoma secretingmonoclonal antibody (mAb) against human MSLN. In this study, we applied the 11-25 mAb to in vivo imaging to detect MSLN-expressing tumors. In in vitro and ex vivo immunochemical studies, we demonstrated specificity of 11-25 mAb to membranous MSLN expressed on several pancreatic cancer cells. We showed the accumulation of Alexa Fluor 750-labeled 11-25 mAb in MSLN-expressing tumor xenografts in athymic nude mice. Then, 11-25 mAb was labeled with Cu-64 via a chelating agent DOTA and was used in both in vitro cell binding assay and in vivo positron emission tomography (PET) imaging in the tumorbearing mice. We confirmed that Cu-64-labeled 11-25 mAb highly accumulated in MSLN-expressing tumors as compared to MSLN negative ones. The Cu-64-labeled 11-25 mAb is potentially useful as a PET probe capable of being used for wide range of tumors, rather than F-18-FDG that occasionally provides nonspecific accumulation into the inflammatory lesions.

    DOI: 10.1155/2015/268172

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  • 創薬を加速する技術の新潮流.最先端の分子イメージングで医療イノベーションを実現 招待

    松浦栄次

    日経サイエンス2015年5月号   2015年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Reconbinant domain V of β2-glycoprotein I inhibits the formation of atherogenic oxLDL/β2-glycoprotein I complexes. 査読

    Li J, Chi Y, Liu S, Wang L, Wang R, Han X, Matsuura E, Liu Q

    J Clin Immunol34 ( 6 ) 669 - 676   2014年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10875-014-0063-y

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  • 7-Ketocholesteryl-9-carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages 査読

    Chi Y, Wang L, Liu Y, Ma Y, Wang R, Han X, Qiao H, Lin J, Matsuura E, Liu S, Liu Q

    Atherosclerosis234 ( 2 ) 461 - 468   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.atherosclerosis.2014.01.052

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  • Is atherosclerosis an autoimmune disease? 査読

    Eiji Matsuura, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Maurizio Turiel, Luis R. Lopez, Michael T. Nurmohamed

    BMC MEDICINE12   47   2014年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Immunologic research into pathogenic mechanisms operating in autoimmune-mediated atherosclerosis initially focused on adaptive immunity. Current interest is directed to more basic inflammatory mechanisms. Chronic inflammation (innate immunity-associated) may trigger initial events that can lead to atherosclerotic cardiovascular disease. This chronic inflammation may start early in life and be perpetuated by classic atherosclerosis risk factors. Lipid peroxidation of low-density lipoprotein seems to be a key event in the initiation and progression of atherosclerosis. Oxidized low-density lipoprotein triggers inflammatory and immunogenic events that promote endothelial dysfunction and the synthesis and secretion of pro-inflammatory cytokines, leading to an autoimmune response capable of accelerating the intracellular accumulation of lipids within atherosclerotic plaques. Oxidized low-density lipoprotein binds beta 2-glycoprotein I to form circulating complexes found in both autoimmune and non-autoimmune atherosclerosis. It is likely that beta 2-glycoprotein I and/or these complexes contribute to early atherogenesis by stimulating pro-inflammatory innate immunity through endogenous sensors and inflammasome/ interleukin-1 pathways. We discuss the chronic inflammatory (innate) and autoimmune (adaptive) responses operating in atherosclerosis to discern the role of autoimmunity in atherosclerotic cardiovascular disease.

    DOI: 10.1186/1741-7015-12-47

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  • Ectopic calcification: Importance of common nanoparticle scaffolds containing oxidized acidic lipids 査読

    Hiromi Kumon, Eiji Matsuura, Noriyuki Nagaoka, Toshio Yamamoto, Shinya Uehara, Motoo Araki, Yukana Matsunami, Kazuko Kobayashi, Akira Matsumoto

    Nanomedicine: Nanotechnology, Biology, and Medicine10 ( 2 ) 441 - 450   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    The term nanobacteria, sometimes referred to as nanobacteria-like particles (NLPs), is presently recognized as a misnomer for inert calcified nanoparticles. However, misinterpretation of its propagation as a living organism still continues. Ultrastructural and elemental analyses, combining immuno-electron microscopy with an original NLP isolate (P-17) derived from urinary stones, and an IgM monoclonal antibody (CL-15) raised against P-17 have now revealed that, oxidized lipids with acidified functional groups were key elements in NLP propagation. Lamellar structures composed of acidic/oxidized lipids provided structural scaffolds for carbonate apatite crystals. During in vitro culture, lipid peroxidation induced by γ-irradiation of FBS was a major cause of accelerated NLP propagation. In pathological tissue samples from hyperlipidemic atherosclerosis-prone mice, CL-15 co-localized with fatty plaques, macrophage infiltrates and osteocalcin staining of aortic valve lesions. These observations indicate that naturally occurring NLP composed of mineralo-oxidized lipids complexes are generated as by-products rather than etiological agents of chronic inflammation. From the Clinical Editor: The term "nanobacteria-like particles (NLPs)" is presently recognized as a misnomer for inert calcified nanoparticles as opposed to living organisms. This study convincingly demonstrates that naturally occurring NLPs composed of mineralo-oxidized lipid complexes are generated as by-products rather than etiological agents of chronic inflammation. © 2014 Elsevier Inc.

    DOI: 10.1016/j.nano.2013.08.010

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  • Platelet thromboxane (11-dehydro-thromboxane B2) and aspirin response in patients with diabetes and coronary artery disease. 査読

    Lopez LR, Guyer KE, Torre IG, Pitts KR, Matsuura E, Ames PR

    World J Diabetes5   115 - 127   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • β2-Glycoprotein I Autoantibodies 査読

    Eiji Matsuura, Luis R. Lopez

    Autoantibodies: Third Edition   689 - 698   2013年12月

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    記述言語:英語   掲載種別:論文集(書籍)内論文   出版者・発行元:Elsevier B.V.  

    Elevated serum levels of antiphospholipid antibodies, venous or arterial thrombosis, and/or pregnancy morbidity (miscarriages, recurrent fetal loss) are the major serologic and clinical features of the antiphospholipid syndrome (APS). Antiphospholipid antibodies belong to a heterogeneous family of autoantibodies that play a crucial role in the development of thrombosis in patients with APS. These antibodies may react with negatively charged phospholipids, phospholipid/protein complexes, and certain plasma proteins attached to suitable surfaces (i.e., activated cell membranes, oxygenated polystyrene). Most antiphospholipid antibodies derived from patients with APS require the presence of certain plasma proteins for optimal phospholipid binding activity. β2-Glycoprotein I (β2GPI), a phospholipid-binding plasma protein, is now recognized as the most clinically relevant antigenic target for antiphospholipid antibodies. Antibodies to β2GPI are more specific for thrombosis (and APS) than anticardiolipin (aCL) antibodies. Recent prospective studies have shown that β2GPI-dependent aCL and anti-γ2GPI antibodies were significant predictors of arterial thrombosis (myocardial infarction and stroke). In addition to natural anticoagulant properties, β2GPI may also bind to oxidized low-density lipoprotein (oxLDL) likely to quench its proinflammatory and atherogenic effects. Circulating oxLDL/β2GPI complexes are immunogenic, and anti-oxLDL/β2GPI antibodies accelerate their macrophage uptake and the development of autoimmune-mediated atherothrombosis. Autoantibodies against oxLDL/β2GPI complexes strongly correlated with arterial thrombosis in patients with systemic lupus erythematosus (SLE) and APS. These findings suggest that β2GPI and anti-γ2GPI antibodies play a central pathogenic role in thrombosis, and particularly in autoimmune-mediated atherosclerosis. © 2014 Elsevier B.V. All rights reserved.

    DOI: 10.1016/B978-0-444-56378-1.00081-2

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  • Laminin-1 (LM-111) in preeclampsia and systemic lupus erythematosus 査読

    Maria-Carolina Paez, Eiji Matsuura, Luis A. Diaz, Yehuda Shoenfeld, Norma C. Serrano, Juan-Manuel Anaya

    AUTOIMMUNITY46 ( 1 ) 14 - 20   2013年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INFORMA HEALTHCARE  

    Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of antibodies. SLE has been associated with placental pathology, a finding that is also the determinant in preeclampsia (PE). Genetic evidence and serologic reports suggest laminin-1 (LM-111) as an immunogenic molecule and its polymorphic gene as a candidate gene for both disorders. Objective: To evaluate the association between LAMA1 (rs543355) and LAMC1 (rs20563) polymorphisms and the presence of SLE and PE as well as to determine serum levels of anti-LM-111 autoantibodies in the PE group. Methods: Group A: 169 women with PE and 172 healthy pregnant women. Group B: 204 women with SLE and 204 healthy women. Anti-LM-111 for group A was measured by ELISA and the genotyping was done by using a PCR system. Results: Group A: Levels of anti-LM-111 was similar in women with PE and the control group (p = 0.3). The allelic frequencies and genotypes did not show statistically significant differences for LAMA1 and LAMC1 polymorphisms. Group B: Significant differences between SLE patients and controls for rs543355 polymorphism were not observed. Nevertheless, LAMC1 rs20563 A-allele provided protection against the development of SLE (OR 0.73, 95% CI 0.55-0.96). Conclusions: Serum levels of anti-LM-111 at the third trimester of gestation do not seem to have any direct relationship with the presence of PE, and the SNPs evaluated are not associated with the risk of developing this disorder. LAMC1 polymorphism could be a protective factor for SLE.

    DOI: 10.3109/08916934.2012.730586

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  • 7-Ketocholesteryl-9-carboxynonanoate enhances the expression of ATP-binding cassette transporter A1 via CD36 査読

    Wenzhe Li, Dan Wang, Yan Chi, Renjun Wang, Fan Zhang, Guang Ma, Zilong Chen, Jingda Li, Zhe Liu, Eiji Matsuura, Qingping Liu

    ATHEROSCLEROSIS226 ( 1 ) 102 - 109   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    Background: CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated.
    Methods and results: OxLig-1 leads to activation and recruitment of Src kinase Fyn, Lyn and caveolin-1 to CD36 in J774A.1 cells, but not in CD36 knockdown cells. The mitogen-activated protein (MAP) kinases c-Jun N-terminal kinase 2 (JNK2) and extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are specifically phosphorylated in J774A.1 cells after treatment with oxLig-1 and inhibited by pretreatment of Src inhibitor, AG1879. The expression of ABCA1 is up-regulated by treatment with oxLig-1in J774A.1 cells, and the increased expression of ABCA1 is dramatically down-regulated by pretreatment with pharmacological inhibitors of ERK (PD98059) and JNK (SP600125).
    Conclusions: The specific CD36 signal induced by oxLig-1 initiated the activation of Fyn, Lyn, caveolin-1, JNK2 and ERK1/2, and resulted in the up-regulation of ABCA1. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

    DOI: 10.1016/j.atherosclerosis.2012.10.038

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  • A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging 査読

    Teruaki Toyota, Tadashi Hanafusa, Takashi Oda, Iwane Koumura, Takanori Sasaki, Eiji Matsuura, Hiromi Kumon, Tsuneo Yano, Toshiro Ono

    Journal of Radioanalytical and Nuclear Chemistry298 ( 1 ) 295 - 300   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals. © 2012 The Author(s).

    DOI: 10.1007/s10967-012-2340-7

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  • 岡山大学におけるPET研究施設の治験薬GMP(Good Manufacturing Practice)体制 招待

    佐々木崇了, 松浦栄次, 公文裕巳, 矢野恒夫

    Pharm Tech Japan29   123 - 128   2013年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • β2-glycoprotein I and oxidative inflammation in early atherogenesis: A progression from innate to adaptive immunity? 査読

    Matsuura E, Lopez LR, Shoenfeld Y, Ames PR

    Autoimmun Rev12 ( 2 ) 241 - 249   2012年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.autrev.2012.04.003

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  • Two young-adult female cases of dermatomyositis with antibodies for transcriptional intermediary factor 1-γ. 査読

    Matsuura E, Ishiguro N, Katsumata Y, Urano W, Yamanaka H, Kondo M, Kuwana M, Kaji K, Hamaguchi Y, Fujimoto M, Kawashima M

    European journal of dermatology : EJD22 ( 5 ) 668 - 671   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1684/ejd.2012.1824

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  • On aspirin treatment but not baseline thromboxane B2 levels predict adverse outcomes in patients with acute coronary syndromes 査読

    E. Matsuura, K. Guyer, H. Yamamoto, L. R. Lopez, K. Inoue

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS10 ( 9 ) 1949 - 1951   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    DOI: 10.1111/j.1538-7836.2012.04845.x

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  • Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus 査読

    Paul R. J. Ames, Joana R. Batuca, Ivana J. Muncy, Ignacio Garcia De la Torre, Sara Pascoe-Gonzales, K. Guyer, E. Matsuura, Luis R. Lopez

    THROMBOSIS RESEARCH130 ( 3 ) 350 - 354   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Introduction: Aspirin (ASA) irreversibly inhibits platelet cyclooxygenase-1 (COX-1) leading to decreased thromboxane-mediated platelet activation. The effect of ASA ingestion on platelet activation, thromboxane generation, oxidative stress and anti-oxidant biomarkers was studied in type 2 diabetes mellitus (DM). Material and methods: Baseline and post-ASA samples (100/325 mg x 7 days) were obtained from 75 DM patients and 86 healthy controls for urinary 11-dehydro-thromboxane B2 (11dhTxB2), 8-iso-prostaglandin-F2 alpha (8-isoPGF2 alpha) and serum sP-Selectin, nitrite (NO2-), nitrate (NO3-) and paraoxonase 1 (PON1) activity. Results: Compared to baseline controls, baseline DM had higher mean levels of 11dhTxB2 (3,665 +/- 2,465 vs 2,450 +/- 1,572 pg/mg creatinine, p=0.002), 8-isoPGF2 alpha (1,457 +/- 543 vs 1,009 +/- 412 pg/mg creatinine, p<0.0001), NO2-(11.8 +/- 7.3 vs 4.8 +/- 5.3 mu M, p<0.0001), NO3-(50.4 +/- 39.3 vs 20.9 +/- 16.7 mu M, p<0.0001) and sP-Selectin (120.8 +/- 56.7 vs 93.0 +/- 26.1 ng/mL, p=0.02), and the same held for post-ASA levels (p<0.0001). ASA demonstrated no effect on 8-isoPGF2 alpha, NO2-, NO3-, sP-Selectin or PON1 activity in either DM or controls. Post ASA inhibition of urinary 11dhTxB2 was 71.5% in DM and 75.1% in controls. There were twice as many ASA poor responders in DM than in controls (14.8% and 8.4%) based on systemic thromboxane reduction. Urinary 8-isoPGF2 alpha excretion was greater in DM ASA poor responders than good responders (p<0.009). Conclusions: This suggests that oxidative stress may maintain platelet function irrespective of COX-1 pathway inhibition and/or increase systemic generation of thromboxane from non-platelet sources. (C) 2012 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.thromres.2012.03.025

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  • Persimmon (Diospyros Kaki Thunb ‘Saijo’) peel improved dyslipidemia and its related production of atherogenic autoantigen complexes in low-density lipoprotein receptor-deficient mice. 査読

    Quan N, Kobayashi K, Matsunami Y, Ide M, Makarova M, Shen L, Ohno S, Zheng Y, Kobayashi H, Lopez LR, Matsuura E

    Open Nutr J6   12 - 20   2012年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • A Possible Mechanism of Autoimmune-Mediated infertility in Women with Endometriosis 査読

    Junko Inagaki, Lin Hao, Mikiya Nakatsuka, Tatsuji Yasuda, Yuji Hiramatsu, Yehuda Shoenfeld, Eiji Matsuura

    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY66 ( 2 ) 90 - 99   2011年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY-BLACKWELL  

    Problem
    Endometriosis has been proposed to be an autoimmune disease because of the presence of a variety of autoantibodies specific for endometrial or ovarian antigens. The object of the present study is to characterize binding specificity of anti-laminin-111 autoantibodies in infertile patients with endometriosis and to investigate whether these autoantibodies affect the in vitro embryo development.
    Method of study
    An ELISA analysis using overlapping synthesized peptides that covered the entire G domain of laminin-alpha 1 chain was performed in infertile patients with endometriosis (n = 45). Mouse blastocysts were cultured in media containing the purified IgG from one antibody-positive serum on laminin-111-coated dishes.
    Results
    Anti-laminin-111 autoantibodies were directed to several particular biologically functional peptide sequences in laminin-alpha 1 chain G domain. The tested IgG significantly inhibited the extent of in vitro trophoblast outgrowth.
    Conclusion
    Anti-laminin-111 autoantibodies may have major pathogenic roles on early reproductive failure including endometriosis-associated infertility.

    DOI: 10.1111/j.1600-0897.2010.00956.x

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  • In Vivo Oxidation, Platelet Activation and Simultaneous Occurrence of Natural Immunity in Atherosclerosis-Prone Mice 査読

    Lianhua Shen, Yukana Matsunami, Nanhu Quan, Kazuko Kobayashi, Eiji Matsuura, Keiji Oguma

    ISRAEL MEDICAL ASSOCIATION JOURNAL13 ( 5 ) 278 - 283   2011年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ISRAEL MEDICAL ASSOC JOURNAL  

    Background: Several murine models are susceptible to atherosclerosis, such as low density-lipoprotein receptor-deficient (LDLR(-/-)) and apolipoprotein E-deficient (apoE(-/-)) mice, and are used for studying pathophysiological mechanisms. Atherosclerotic lesions in the aortic valve and thoracic/abdominal aorta are commonly associated with hyperlipidemia. We recently demonstrated the development of large atherosclerotic plaques in Helicobacter pylori-infected heterozygous LDLR(+/-) apoE(+/-) mice.
    Objectives: To measure novel biomarkers related to atherosclerosis, blood coagulation, and oxidative stress in order to investigate their possible pathogenic roles in atherosclerosis-prone mice.
    Methods: Mice were fed with a normal chow diet or high-fat diet and sacrificed at different age intervals to measure aortic plaque size. Plasma cholesterol was enzymatically measured. Enzyme-linked immunosorbent assay was used to measure oxidized LDL (oxLDL)/beta-2-glycoprotein I (beta 2GPI) complexes, immunoglobulin M (IgM) antibodies against native LDL, oxLDL, or oxLDL/beta 2GPI, and urine 11-dehydrothromboxane B2 (11-dhTxB(2)) or 8-hydroxy-deoxyguanosine.
    Results: There was a parallel increase in plaque size, plasma cholesterol, and urinary 11-dhTxB(2) in atherosclerosis-prone mice. In contrast to atherosclerosis-prone strains, an elevation of urinary 11-dhTxB(2) with no significant plaque generation was observed in LDLR(+/-) apoE4 mice. The atherogenic autoantigen oxLDL/beta 2GPI complex was detected only in LDLR(-/-) mice. These levels seem to depend on plaque size. IgM antibodies against oxLDL in apoE(-/-) mice were found, accompanied by atherosclerotic progression.
    Conclusions: Progression of atherosclerotic lesions was associated not only with hypercholesterolemia but also with platelet activation and natural autoimmune-mediated regulatory mechanism(s) in murine models. IMAJ 2011; 13: 278-283

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  • Recombinant domain V of β2-glycoprotein I inhibits the formation of a 7-ketocholesteryl-9-carboxynonanoate and β2-glycoprotein I complex. 査読

    Zhang Y, Li W, Chi Y, Wang R, Wang D, Zhang F, Liu Z, Matsuura E, Liu Q

    J Biochem149 ( 1 ) 35 - 42   2011年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jb/mvq111

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  • 自己免疫・感染免疫が惹起する動脈硬化〜岡山発の“自己抗体に世路次世代標的医療” 招待

    松浦栄次

    BIOTOVO2011年11月号   2011年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Rosuvastatin treatment is associated with a decrease of serum oxidised low-density lipoprotein/beta2-glycoprotein i complex concentration in type 2 diabetes 査読

    Paul Rj Ames, Alfredo Ortiz-Cadenas, Ignacio Garcia-De La Torre, Arnulfo Nava, Aldo Oregon-Miranda, Joana R Batuca, Kazuo Kojima, Luis R Lopez, Eiji Matsuura

    British Journal of Diabetes and Vascular Disease10 ( 6 ) 292 - 299   2010年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Aims To evaluate the effect of rosuvastatin on oxidised low-density lipoprotein/beta2-glycoprotein I (oxLDL/ β2GPI) complex concentration in type 2 diabetes mellitus. Methods: open label 2:1 assignment of consecutive diabetic patients into oral rosuvastatin (10 mg daily for six weeks) arm or observational arm with measurements of serum oxLDL/ β2GPI complexes, nitric oxide metabolites, asymmetric dimethyl arginine, nitrotyrosine alongside routine biochemistry at baseline and end of study in all patients. Results After rosuvastatin treatment the mean serum concentration of oxLDL/β2GPI decreased from 0.79±0.49 units/mL to 0.53±0.36 units/mL (p&lt
    0.001). The decrease was statistically independent from the decrements of mean cholesterol, LDL and triglyceride concentrations (p&lt
    0.001) but probably dependent on the decrement of nitrate (p&lt
    0.001). Conclusion In type 2 diabetes, treatment with rosuvastatin was associated with a significant reduction of serum concentrations of oxLDL/β2GPI complexes, which is in further support of the already proposed effects of the drug on the oxidative metabolism of lipids and/or LDL. The oxLDL/β2GPI complex may represent a surrogate marker of oxidative stress in type 2 diabetes. © The Author(s), 2010.

    DOI: 10.1177/1474651410388057

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  • 7-Ketocholesteryl-9-carboxynonanoate induced nuclear factor-kappa B activation in J774A.1 macrophages 査読

    Zhenyu Huang, Wenzhe Li, Renjun Wang, Fan Zhang, Yan Chi, Dan Wang, Zhe Liu, Yingbiao Zhang, Eiji Matsuura, Qingping Liu

    LIFE SCIENCES87 ( 19-22 ) 651 - 657   2010年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Aims: 7-Ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxidized low-density lipoprotein (oxLDL), has been reported to be a crucial ligand of beta2-glycoprotein I (beta(2)-GPI), and plays a potential role in the development of atherosclerosis (AS), however, the role of the sole oxLig-1 in the development of AS remains unclear.
    Main methods: Expression and phosphorylation levels of several proteins, such as nuclear factor-kappaB (NF-kappa B), protein kinase C (PKC), I kappa B alpha and inter-cellular adhesion molecule 1 (ICAM-1) were determined by Western blot; nuclear localization of NF-kappa B was studied by immunocytochemistry; NF-kappa B activation was assayed by electrophoretic mobility shift assay (EMSA); and expressions of genes associated with AS process were investigated by Mouse Atherosclerosis RT(2) Profiler PCR Array assay.
    Key findings: The present work indicated that oxLig-1 induced I kappa B alpha phosphorylation and results in the nuclear translocation of NF-kappa B in J774A.1 macrophages. Moreover, oxLig-1-induced NF-kappa B DNA binding activity was detected by EMSA. Indeed, oxLig-1 led to the activation of PKC prior to activating NF-kappa B. The treatment of oxLig-1 in J774A.1 macrophages up-regulates the expression of NF-kappa B target genes including ICAM-1
    Significance: OxLig-1 on the oxLDL plays an important role in AS process, as evidenced by the NF-kappa B activation and up-regulation of genes involved in AS development in oxLig-1 challenged J774A.1 macrophages. (C) 2010 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.lfs.2010.09.028

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  • Oxidized-LDL/β2-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes. 査読

    Greco TP, Conti-Kelly AM, Anthony JR, Greco T Jr, Doyle R, Boisen M, Kojima K, Matsuura E, Lopez LR

    Am J Clin Pathol133 ( 5 ) 737 - 743   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1309/AJCP88WVRDRDFBAS

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  • High-density lipoprotein inversely relates to its specific autoantibody favoring oxidation in thrombotic primary antiphospholipid syndrome 査読

    P. R. J. Ames, E. Matsuura, J. R. Batuca, A. Ciampa, L. L. Lopez, F. Ferrara, L. Iannaccone, J. Delgado Alves

    LUPUS19 ( 6 ) 711 - 716   2010年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS LTD  

    Abnormalities of the lipid profile partly explain the atherogenic tendency of systemic lupus erythematosus but the picture is unclear in thrombotic primary antiphospholipid syndrome (PAPS). Herein we compare the lipid profile, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol (CHO), apolipoprotein A (ApoA-I), apolipoprotein B (ApoB), tryglicerides (TRY)), anti-lipoprotein antibodies, beta-2-glycoprotein I complexed to oxidized low-density lipoprotein (oxLDL-beta(2)GPI) and C-reactive protein (CRP) from thrombotic PAPS (n = 34), thrombotic patients with inherited thrombophilia (IT; n = 36), subjects persistently positive for antiphospholipid antibodies (aPL, n = 18) with no underlying autoimmune or non-autoimmune disorders and healthy controls (n 28) and determined the reciprocal effects of anti-lipoprotein antibodies, the lipid profile, oxLDL-beta(2)GPI and CRP. Average concentrations of HDL (p < 0.0001), LDL (p < 0.0001), CHO (p = 0.0002), ApoA-I (p = 0.002) were lower in PAPS whereas average TRY was higher (p = 0.01) than other groups. Moreover, the aPL and PAPS group showed higher levels of IgG anti-HDL (p 0.01) and IgG anti-ApoA-I (p < 0.0001) whereas the PAPS group showed greater average oxLDL-beta(2)GPI (p = 0.001) and CRP (p = 0.003). Within the PAPS group, IgG anti-HDL correlated negatively to HDL (p = 0.004) and was an independent predictor of oxLDL-beta(2)GPI (p = 0.009). HDL and ApoA-I correlated negatively with CRP (p 0.001 and p = 0.007, respectively). IgG anti-HDL may hamper the antioxidant and anti-inflammatory effect of HDL favoring low-grade inflammation and enhanced oxidation in thrombotic PAPS. Lupus (2010) 19, 711-716.

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  • 7-Ketocholesterol Induces Cell Apoptosis by Activation of Nuclear Factor kappa B in Mouse Macrophages 査読

    Zhenyu Huang, Qingping Liu, Wenzhe Li, Renjun Wang, Dan Wang, Yingbiao Zhang, Fan Zhang, Yan Chi, Zhe Liu, Eiji Matsuura, Zibo Liu, Qiming Zhang

    ACTA MEDICA OKAYAMA64 ( 2 ) 85 - 93   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We investigated the molecular mechanisms responsible for the induction of apoptosis in mouse monocytic macrophage cell line J774A.1 stimulated by 7-ketocholesterol (7-KC). Cell apoptosis was detected by Annexin V-propidium iodide (PI) staining. The DNA-binding activity of nuclear factor kappa B (NF-kappa B) was assessed by electrophoretic mobility shift assay (EMSA). Results showed that 7-KC-stimulation in J774A.1 cells activated NF-kappa B, which is involved in cell apoptosis, in a time- and dose-dependent manners. 7-KC was also found to increase the binding activity of NF-kappa B to specific DNA binding sites, a possible mechanism for the induction of the cell apoptosis. Moreover, these effects were partially inhibited by pyrrolidine dithiocarbamate (PDTC), an NF-kappa B inhibitor. Taken together, 7-KC may be an important factor in atherosclerosis due to the ability of 7-KC to induce cell apoptosis, which is at least partially mediated through the activation of NF-kappa B.

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  • Pathophysiology of β2-glycoprotein I in antiphospholipid syndrome. 査読

    Matsuura E, Shen L, Matsunami Y, Quan N, Makarova M, Geske FJ, Yasuda S, Kobayashi K, Lopez LR

    Lupus19 ( 4 ) 379 - 384   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1177/0961203310361352

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  • The role of oxidized low-density lipoprotein/β2-glycoprotein I complexes in autoimmune-mediated atherothrombosis. 査読

    Lopez LR, Geske FJ, Boisen M, Kobayashi K, Matsunami Y, Matsuura E

    International Atherosclerosis Society – published online (www.athero.org),May, 2010   2010年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

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  • High Expression of CD244 and SAP Regulated CD8(+) T Cell Responses of Patients with HTLV-I Associated Neurologic Disease 査読

    Yoshimi Enose-Akahata, Eiji Matsuura, Unsong Oh, Steven Jacobson

    PLOS PATHOGENS5 ( 12 )   2009年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PUBLIC LIBRARY SCIENCE  

    HTLV-I-specific CD8(+) T cells have been characterized with high frequencies in peripheral blood and cerebrospinal fluid and production of proinflammatory cytokines, which contribute to central nervous system inflammation in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However, little is known about the differences in CD8+ T cell activation status between asymptomatic carrier (ACs) and patients with HAM/TSP. The expression of CD244, a signaling lymphocyte activation molecule (SLAM) family receptor, was significantly higher on CD8(+) T cells in HTLV-I-infected patients, both ACs and patients with HAM/TSP, than those on healthy normal donors (NDs). Blockade of CD244 inhibited degranulation and IFN-gamma production in CD8(+) T cells of patients with HAM/TSP, suggesting that CD244 is associated with effector functions of CD8(+) T cells in patients with HAM/TSP. Moreover, SLAM-associated protein (SAP) was overexpressed in patients with HAM/TSP compared to ACs and NDs. SAP expression in Tax-specific CTLs was correlated in the HTLV-I proviral DNA loads and the frequency of the cells in HTLV-I-infected patients. SAP knockdown by siRNA also inhibited IFN-gamma production in CD8(+) T cells of patients with HAM/TSP. Thus, the CD244/SAP pathway was involved in the active regulation of CD8(+) T cells of patients with HAM/TSP, and may play roles in promoting inflammatory neurological disease.

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  • Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis 査読

    K. Ayada, K. Yokota, K. Hirai, K. Fujimoto, K. Kobayashi, H. Ogawa, K. Hatanaka, S. Hirohata, T. Yoshino, Y. Shoenfeld, E. Matsuura, K. Oguma

    LUPUS18 ( 13 ) 1154 - 1168   2009年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS LTD  

    Helicobacter pylori (H. pylori) is a predominant pathogen that causes not only gastroduodenal diseases but also extra-alimentary tract diseases. In this study, we demonstrated that H. pylori infection promoted atherogenesis in heterozygous apoe(+/-) ldlr(+/-) mice. The male mice were fed with high fat diet from the age of 6 weeks. At the age of 16 weeks, development of atherosclerotic lesions was observed in the H. pylori-infected mice, and it seemed to be associated with an elevation of Th1-immune response against H. pylori origin-heat shock protein 60 (Hp-HSP60) and an increment of transendothelial migration of T cells. Subcutaneous immunisation with Hp-HSP60 or H. pylori eradication with antibiotics significantly reduced the progression of atherosclerosis, accompanied by a decline of Th1 differentiation and reduction of their chemotaxis beyond the endothelium. Thus, oral infection with H. pylori accelerates atherosclerosis in mice and the active immunisation with Hp-HSP60 or the eradication of H. pylori with antibiotics can moderate/prevent cellular immunity, resulting in a reduction of atherosclerosis. Lupus (2009) 18, 1154-1168.

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  • Autoimmunity, Infectious Immunity, and Atherosclerosis 査読

    Eiji Matsuura, Kazuko Kobayashi, Yukana Matsunami, Lianhua Shen, Nanhu Quan, Marina Makarova, Sergey V. Suchkov, Kiyoshi Ayada, Keiji Oguma, Luis R. Lopez

    JOURNAL OF CLINICAL IMMUNOLOGY29 ( 6 ) 714 - 721   2009年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER/PLENUM PUBLISHERS  

    Vascular inflammation is common in certain systemic autoimmune diseases and contributes to the oxidation of low-density lipoprotein (oxLDL) and oxLDL/beta 2-glycoprotein I (beta 2GPI) complex formation. These complexes have been implicated as proatherogenic autoantigens that participate in the development of atherosclerotic disease.
    We have demonstrated that the in vitro macrophage uptake of oxLDL/beta 2GPI complexes increases in the presence of IgG anti-beta 2GPI antibodies and that IgG immune complexes containing oxLDL/beta 2GPI upregulate the expression of both scavenger and Fc gamma receptors to activate beta 2GPI-specific T cells. Some persistent infections may cause immune responses that promote atherogenesis. Cellular immunity (Th1) against Helicobacter pylori (H. pylori) derived heat shock protein 60 (Hp-HSP60) cross-reacts with endogenous HSP60 to cause cardiovascular disease likely by molecular mimicry.
    Infectious cellular response may be proatherogenic, while the humoral response (antibody production) may be protective. We review the recent progress in our understanding of autoimmunity and infectious immunity that promote atherosclerosis.

    DOI: 10.1007/s10875-009-9333-5

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  • Newer Antiphospholipid Antibodies Predict Adverse Outcomes in Patients With Acute Coronary Syndrome 査読

    Thomas P. Greco, Ann Marie Conti-Kelly, Thomas Greco, Robin Doyle, Eiji Matsuura, J. Robert Anthony, Luis R. Lopez

    AMERICAN JOURNAL OF CLINICAL PATHOLOGY132 ( 4 ) 613 - 620   2009年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC CLINICAL PATHOLOGY  

    Antiphospholipid antibodies (aPLs) have been implicated in atherogenesis. We studied 344 patients with acute coronary syndromes; approximately 40% were aPL+ in I or more tests and 60% aPL-. In 215 patients, coronary artery disease (CAD) was angiographically documented, with 43.7% positive for aft vs 34.9% of patients without CAD positive for aPLs. Anti-beta(2)-glycoprotein I (B2GPI; 54%) and anti-oxidized low-density; lipoprotein (oxLDL)/beta 2GPI (48%) were most frequent, accounting for 87% of all aPL+ CAD cases. aPLs correlated with severity of CAD (P=.012). Adverse events occurred in 16 7% of patients with CAD, more frequently in patients who were aPL+ (P=.0006; relative risk, 2.9; 95% confidence interval, 1.5-5.6). Patients who were aPL + with severe CAD had more adverse events than patients who were aPL- with severe CAD (P=.005) and aPL+patients undergoing revascularization procedures (P=.001). Vascular events occurred in 21.7% of aPL + patients compared with 7.1% of aPL-patients (P=.005). Anti-beta 2GPI and anti-oxLDL/beta 2GPI were associated with CAD severity and adverse outcomes.

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  • Nicked β2-glycoprotein I binds angiostatin 4.5 (plasminogen kringle 1-5) and attenuates its antiangiogenic property. 査読

    Nakagawa H, Yasuda S, Matsuura E, Kobayashi K, Ieko M, Kataoka H, Horita T, Atsumi T, Koike T

    Blood114 ( 12 ) 2553 - 2559   2009年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1182/blood-2008-12-190629

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  • Atherosclerosis and Autoimmunity 査読

    Eiji Matsuura

    CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY37 ( 1 ) 1 - 3   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HUMANA PRESS INC  

    DOI: 10.1007/s12016-008-8092-z

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  • Immunogenic oxidized low-density lipoprotein/β2-glycoprotein I complexes in the diagnostic management of atherosclerosis. 査読

    Lopez LR, Kobayashi K, Matsunami Y, Matsuura E

    Clin Rev Allergy Immunol37 ( 1 ) 12 - 19   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s12016-008-8096-8

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  • Chronic Infections and Atherosclerosis 査読

    Kiyoshi Ayada, Kenji Yokota, Kazuko Kobayashi, Yehuda Shoenfeld, Eiji Matsuura, Keiji Oguma

    CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY37 ( 1 ) 44 - 48   2009年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HUMANA PRESS INC  

    The immune response against heat shock protein 60 (HSP60) derived from pathogens causing chronic infections is thought to be an important pro-atherogenic mechanism because high serum levels of antibodies against HSP60 have been associated with atherosclerotic diseases, such as coronary artery diseases, or cerebro-vascular events. Furthermore, the presence of HSP60-specific T lymphocytes in circulation may increase the risk of atherosclerosis. Our recent in vitro and in vivo studies have also shown an association of Helicobacter pylori-HSP60 (Hp-HSP60) specific Th1 immune responses elicited by H. pylori infection with the progression of atherosclerosis in a hyperlipidemic mouse model. These Th1 dominant immune responses may cross-react with endogenous HSP60 expressed on stressed cells of the vascular endothelium, likely due to molecular mimicry. However, the exact mechanisms by which endothelial cells display their HSP60 molecule or present HSP60 antigenic epitopes on the surface are still unclear.

    DOI: 10.1007/s12016-008-8097-7

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  • The immunology of atherothrombosis in the antiphospholipid syndrome: Antigen presentation and lipid intracellular accumulation 査読

    Eiji Matsuura, Kazuko Kobayashi, Yukana Matsunami, Luis R. Lopez

    AUTOIMMUNITY REVIEWS8 ( 6 ) 500 - 505   2009年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    The antiphospholipid syndrome (APS), characterized by elevated serum levels of anti phospholipid antibodies (aPL) and thromboembolic complications, is a common cause of acquired hypercoagulability. The plasma protein beta 2-glycoprotein I (beta 2GPI) is the most clinically relevant antigenic target for aPL. Recent experimental evidence from our laboratory substantiated the concept that IgG anti-beta 2GPI immune complexes containing oxidized LDL (oxLDL) not only facilitated the intracellular accumulation of oxLDL in macrophages but also allowed the presentation of beta 2GPI epitopes to pathogenic autoreactive T cells. Both mechanisms required Fc gamma RI-mediated uptake by macrophages/monocytes. Furthermore, several clinical studies demonstrated that the presence of circulating oxLDL/beta 2GPI complexes and IgG autoantibodies to these complexes was significantly associated with vascular inflammation (i.e. autoimmune-mediated atherothrombosis) in autoimmune patients. In this article, we review recent findings concerning the biochemical and immunologic mechanisms involved in autoimmune-mediated atherothrombosis in patients with APS. (C) 2009 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.autrev.2008.12.018

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  • Atherosclerosis in autoimmune diseases 査読

    Eiji Matsuura, Kazuko Kobayashi, Luis R. Lopez

    Current Rheumatology Reports11 ( 1 ) 61 - 69   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Lipid peroxidation occurs frequently in patients with systemic autoimmune diseases and contributes to autoimmune vascular inflammation. Oxidized low-density lipoprotein (oxLDL) interacts with β2-glycoprotein I (β2GPI), forming oxLDL/β2GPI complexes. Circulating oxLDL/β2GPI complexes and autoantibodies to these complexes have been demonstrated in patients with systemic lupus erythematosus and antiphospholipid syndrome. These findings suggest an immunogenic nature of the complexes and an active proatherogenic role in autoimmunity. Biochemical characterization of the complexes and immunohistochemical studies of atherosclerotic lesions suggest that most of the complexes originate in the arterial wall and are released into circulation. The in vitro macrophage uptake of oxLDL/β2GPI complexes increased significantly in the presence of antiphospholipid antibodies (anti-β2GPI), suggesting that macrophage Fcγ receptors are involved in the lipid intracellular inflthat leads to foam cell formation. These findings provide an immunologic explanation for the accelerated development of atherosclerosis seen in systemic lupus erythematosus and antiphospholipid syndrome. © Springer Science+Business Media, LLC 2009.

    DOI: 10.1007/s11926-009-0009-1

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  • 感染と動脈血栓 招待

    松浦栄次, 小林和子, 申 蓮花, 松並由香菜, 綾田 潔, 小熊惠二

    日本血栓止血学会誌20   534 - 538   2009年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 自己免疫・感染免疫と動脈硬化 招待

    松浦栄次, 小林和子

    基礎老化研究33   3 - 9   2009年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • oxLDL/β2GPI complex and anti-oxLDL/β2GPI in SLE: prevalence and correlates. 査読

    Bassi N, Zampieri S, Ghirardello A, Tonon M, Zen M, Beggio S, Matsuura E, Doria A

    Autoimmunity42 ( 4 ) 289 - 291   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/08916930902828247

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  • New impacts of cutaneous lupus erythematosus for global standard concepts. 査読

    Furukawa F, Matsuura E

    Autoimmun Rev8   439 - 440   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • POST-INFECTIOUS CLINICAL-IMMUNOLOGICAL SYNDROME AND ITS PLACE IN CLINICAL PRACTICE 査読

    N. E. Cherepakhina, Z. S. Shogenov, T. Elbeik, K. A. Akhmedilova, M. M. Agirov, Zh. A. Tabaksoyeva, E. A. Ogneva, E. Matsuura, N. A. Mukhin, Y. Shoenfeld, M. A. Paltsev, S. V. Suchkov

    TERAPEVTICHESKII ARKHIV81 ( 12 ) 71 - 78   2009年

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    記述言語:ロシア語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IZDATELSTVO MEDITSINA  

    The progression of chronic-relapsing infectious disease (CRID) depends on a combination of cumulative immune-mediated responses of the human body, which, in turn, are united by a number of the common mechanisms. The mechanisms are called as the post-infectious clinical-immunological syndrome (PICIS) to demonstrate the features and scale of imbalances of immune homeostasis. PICIS usually accompanies most of the known CRID to define the type of the disease, to predict the progression of, and risks for the complications to be risen as well. PIFIS is generally provoked by either infectious pathogens of various nature or by the atypical immune responses from the infected patient, or by the onset of the disease itself, or by the inadequate antimicrobial therapy.
    Three forms of PICIS which depend on two key factors have been described These included (i) the spectrum of a microbial colonization landscape; (ii) the antimicrobial immunity itself to generate, for instance., either (if three alternative PICIS, namely, (1) postinfectious secondary immunodeficiency syndrome (PISIS); (2) postinfectious autoimmune syndrome (PIAIS), and (3) PISIS combined with PINS, i.e. PISIDAS.
    The dominant monosyndrome-like form of associated immune imbalances in CRID patients is PISIS. PISIS occurs in more than a third of the clinical cases to stress the autoaggression (PIFAS), or combininative form ojthe immune-mediated imbalances, i.e. PISIDAS. In the process of the development of CRID, PISIS can give a way to either PIAIS or PISIDAS.
    Besides the immune-mediated imbalances, an essential role in the pathogenesis of CRID and PICIS is also attributed to the infectious factors capable of forming microbial associates in the pathogenesis of PICIS. Therefore, treatment of such patients should be directed not only at the elimination of the infectious pathogen(s), but also at the restoration of the physiological level of the immune homeostasis impaired by PICIS.

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  • Primary antiphospholipid syndrome: a low-grade auto-inflammatory disease 査読

    P. R. J. Ames, I. Antinolfi, A. Ciampa, J. Batuca, G. Scenna, L. R. Lopez, J. Delgado Alves, L. Iannaccone, E. Matsuura

    RHEUMATOLOGY47 ( 12 ) 1832 - 1837   2008年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    Objective. To test the inflammation and immune activation hypothesis in primary thrombotic APS (PAPS) and to identify clinical and laboratory factors related to inflammation and immune activation.
    Methods. PAPS (n 41) patients were compared with patients with inherited thrombophilia (IT, n 44) and controls (CTR, n 39). IgG aCL, IgG anti-2-glycoprotein I ((2)GPI), high-sensitivity CRP (hs-CRP), serum amyloid A (SAA), CRP bound to oxidized low-density lipoprotein(2)GPI complex (CRPoxLDL(2)GPI) (as inflammatory markers) neopterin (NPT), soluble CD14 (sCD14) (as immune activation markers) were measured by ELISA.
    Results. After correction for confounders, PAPS showed higher plasma levels of hs-CRP (P 0.0004), SAA (P 0.01), CRPoxLDL(2)GPI (P 0.0004), NPT (P 0.0001) and sCD14 (P 0.007) than IT and CTR. Two regression models were applied to the PAPS group: in the first, IgG aCL and IgG (2)GPI were included amongst the independent variables and in the second they were excluded. In the first model, SAA (as the dependent variable) independently related to thrombosis number (P 0.003); NPT (as the dependent variable) independently related to thrombosis type (arterial, P 0.03) and number (P 0.04); sCD14 (as the dependent variable) independently related to IgG (2)GPI (P 0.0001), age (0.001) and arterial thrombosis (P 0.01); CRPoxLDL(2)GPI (as the dependent variable) independently related to IgG (2)GPI (P 0.0001). In the second model, sCD14 and NPT independently related to each other (P 0.002) (this was noted also in the IT group, P 0.0001) and CRPoxLDL(2)GPI independently predicted SAA (P 0.002).
    Conclusion. Low-grade inflammation and immune activation occur in thrombotic PAPS and relate to clinical features and aPL levels.

    DOI: 10.1093/rheumatology/ken382

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  • Self-interaction of soluble and surface-bound beta 2-glycoprotein I and its enhancement by lupus anticoagulants 査読

    Akira Hayashi, Ayumi Hayashi, Eiji Matsuura, Koji Suzuki, Takao Koike, Eikichi Hashimoto, Hiroyuki Takeya

    FEBS LETTERS582 ( 23-24 ) 3308 - 3312   2008年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Antiphospholipid antibodies found in antiphospholipid syndrome are autoantibodies to phospholipid-binding proteins, such as beta 2-glycoprotein I (beta 2GPI). We have previously reported that among these antibodies, the so-called lupus anticoagulants (LAs) augment beta 2GPI binding to the phospholipid membrane surface, which is associated with the pathological action of LAs. However, the molecular mechanisms underlying this augmentation are uncertain. Here we show that beta 2GPI, which is monomeric in solution, self-interacts at the interface of soluble and surface-bound molecules. In addition, this self-interaction is enhanced by LA-positive, but not LA-negative, anti-beta 2GPI monoclonal antibodies. This study suggests that beta 2GPI self-interaction upon surface binding could be involved in the LA-induced potentiation of b2GPI binding to the phospholipid surface.

    DOI: 10.1016/j.febslet.2008.09.037

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  • Self-interaction of soluble and surface-bound β2-glycoprotein I and its enhancement by lupus anticoagulants. 査読

    Hayashi A, Matsuura E, Suzuki K, Koike T, Hashimoto E, Takeya H

    FEBS Lett582 ( 23-24 ) 3308 - 3312   2008年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.febslet.2008.09.037

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  • Oxidation of LDL and its clinical implication 査読

    Eiji Matsuura, Graham R. V. Hughes, Munther A. Khamashta

    AUTOIMMUNITY REVIEWS7 ( 7 ) 558 - 566   2008年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Oxidative modification of low-density lipoprotein (LDL) is one of the earliest events in atherosclerosis. Oxidized LDL (oxLDL) represents a variety of modification of both lipid and apolipoprotein B (apoB) components by lipid peroxidation. This promotes atherosclerosis through inflammatory and immunologic mechanisms that lead to the formation of macrophage foam cells. Recent findings also suggest that oxLDL forms complexes with beta(2)-glycoprotein I (beta(2)GPI) and/or C-reactive protein (CRP) within atherosclerotic lesions and that these complexes appear in the circulation. Autoantibodies (auto-Abs) against oxLDL/beta(2)GPI complexes occur in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). These autoantibodies significantly correlate with arterial thrombosis. IgG auto-Abs having similar specificity emerge spontaneously in NZW x BXSB F1 mice, which generally are considered to be an animal model of APS, and these mice produce a monoclonal IgG auto-Ab (WB-CAL-1) against oxLDL/beta(2)GPI complexes. WB-CAL-1 significantly increased the in vitro uptake of oxLDL/beta(2)GPI complexes by macrophages, which suggests that such IgG auto-Abs are pro-atherogenic. In contrast, IgM anti-oxLDL natural Abs found in the atherosclerosis-prone mice have been proposed to be protective. The presence of such Abs in humans has been documented in many publications but their exact pathophysiological significance remains unclear. In this article, we review recent progress in our understanding of the clinical significance of oxidation of LDL, formation of oxLDL complexes, and Abs in atherosclerotic and/or autoimmune disease. (C) 2008 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.autrev.2008.04.018

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  • Anti-cardiolipin antibodies and endothelial function in patients with coronary artery disease 査読

    Ibrahim Marai, Michael Shechter, Pnina Langevitz, Boris Gilburd, Ardon Rubenstein, Eiji Matssura, Yaniv Sherer, Yehuda Shoenfeld

    AMERICAN JOURNAL OF CARDIOLOGY101 ( 8 ) 1094 - 1097   2008年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC  

    Endothelial dysfunction is considered an important marker in atherosclerosis, having a prognostic value. Antiphospholipid antibodies are considered prothrombotic and have recently been reported to be associated also with atherosclerosis. This study was conducted to investigate a possible association of endothelial dysfunction with various antiphospholipid autoantibodies in healthy subjects and patients with cardiovascular disease. In a single-center, prospective study, 2 groups were included. The study group included patients with cardiovascular diseases (coronary disease and/or cerebrovascular disease) and healthy subjects without apparent heart disease who were referred to the endothelial function laboratory for the assessment of endothelial function. Flow-mediated dilatation, which indicates endothelial function, and nitroglycerin-mediated vasodilatation, which indicates smooth-muscle function, were measured. The 2 groups were evaluated for autoantibodies, including anticardiolipin (aCL; immunoglobulin G [IgG], immunoglobulin M [IgM], and immunoglobulin A [IgA]), antinuclear antibody, anti-beta 2-glycoprotein I (IgG, IgM, and IgA), and oxidized low-density lipoprotein. One hundred seven subjects were included in the study: 45 patients (42%) and 62 healthy controls (58%). Flow-mediated dilatation was significantly lower in patients compared with healthy controls (8.0 +/- 9.5% vs 8.0 +/- 13.5%, p = 0.012). In addition, nitroglycerin-mediated vasodilatation was nonsignificantly lower in patients than in healthy controls (8.0 +/- 13.4% vs 11.0 +/- 16.7%, p = 0.084). The mean levels of anti-beta 2-glycoprotein I (IgG, IgM, and IgA), aCL (IgM and IgA), antinuclear antibody, and oxidized low-density lipoprotein were not different between groups. However, the mean level of IgG aCL was significantly higher in patients than in healthy controls. In conclusion, in accordance with previous reports of an association between aCL and atherosclerosis, patients with cardiovascular disease had endothelial dysfunction and elevated levels of aCL. (C) 2008 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.amjcard.2007.12.010

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  • Atherosclerosis in primary antiphospholipid syndrome 査読

    Paul R. J. Ames, Giovanna Scenna, Iolanda Antinolfi, Luis Lopez, Luigi Iannaccone, Eiji Matsuura, Annamaria Margarita

    EXPERT REVIEW OF CLINICAL IMMUNOLOGY4 ( 1 ) 53 - 60   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Antiphospholipid syndrome (APS) is the most common cause of acquired thrombophilia, but experimental and clinical evidence accumulated over the years suggest that the clinical manifestations of APS go beyond those of a simple hypercoagulable state. Although still a controversial topic, the elevated risk of atherosclerosis in systemic lupus erythematosus seems little accounted for by the presence of antiphospholipid antibodies, whereas premature atherosclerosis has been addressed in few series of patients with primary APS. The available data in primary APS suggest that traditional risk factors for atherosclerosis are less involved in arterial disease, rather antiphospholipid antibodies appear as major players. Their effect on the coagulation system, the vessel wall and on the antioxidant/oxidant balance impairs vascular homeostasis, leading to premature arterial thickening.

    DOI: 10.1586/1744666X.4.1.53

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  • Preventing autoimmune and infection triggered atherosclerosis for an enduring healthful lifestyle 査読

    Eiji Matsuura, Kazuko Kobayashi, Luis R. Lopez

    AUTOIMMUNITY REVIEWS7 ( 3 ) 214 - 222   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Atherosclerosis is a chronic inflammatory disease of the arteries associated with various risk factors that promote lipid abnormalities (i.e., dyslipidemia), development and progression of atherosclerotic lesions, plaque rupture, and vascular thrombosis. Experimental evidence from biochemical and clinical studies support the idea that arterial thrombosis is an autoimmune process resulting from 'autoantibody'-mediated pro-atherogenic mechanisms now seen in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). In addition, it has been shown that persistent infections of Clamydia pneumoniae (C. pneumoniae), Porphyromonas gingivalis (P. gingivalis), and Helicobacter pylori (H. pylori) cause immune responses (infectious immunity) in their hosts that promote atherogenesis. In this article, we review recent progress in our understanding of immune- and infection-mediated atherosclerosis. (C) 2007 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.autrev.2007.11.008

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  • Autoimmune diseases and infections: controversial issues 査読

    Pierangelo Baio, Antonio Brucato, Dan Buskila, M. Eric Gershwin, Donatella Giacomazzi, Luis R. Lopez, Roberto Luzzati, Eiji Matsuura, Carlo Selmi, Piercarlo Sarzi-Puttini, Fabiola Atzeni

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY26 ( 1 ) S74 - S80   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CLINICAL & EXPER RHEUMATOLOGY  

    The etiology and pathogenesis of certain types of disease remain controversial and stand like a bridge that crosses infectious, autoimmune and autoinflammatory pathways. Infection, for example, may initiate a disease, although it is the genetic regulation in the host, the interplay between virus or bacteria persistence and autoimmunity that produces the later phases of disease, the antigenic determinants responsible for inducing autoimmune disease, and the pathogenetic effector mechanisms. Infections agents cause pericarditis, but in 85% of cases it is "idiopathic". It has also been shown that persistent Clamydia pneumoniae, Porphyromonas gingivalis, and Helicobacter pylori infections cause host immunity and promote atherogenesis. A number of infectious agents have been suggested as potential triggers for primary biliary cirrhosis. Infections and vaccinations have also been linked to the pathogenesis of fibromyalgia syndrome, a common, chronic syndrome of widespread pain. Many factors are also responsible for fever of unknown origin such as: infections, autoimmunity disease, etc. However, it is difficult to determine a direct correlation between the infections, agents in such a large group of diseases. The aim of this review is to analyze some of the controversies about the role of infections in autoimmune diseases.

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  • The role of anti-oxLDL/β2GPI antibodies (anti-AtherOx) in autoimmune-mediated atherosclerosis. 査読

    Lopez LR, Matsuura E

    FOL (AACC–Lipids and Cardiovascular Disease Newsletterpublished online, June 2008   2008年

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    記述言語:英語   掲載種別:研究論文(その他学術会議資料等)  

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  • Autoimmune-mediated atherothrombosis 査読

    E. Matsuura, L. R. Lopez

    LUPUS17 ( 10 ) 878 - 887   2008年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS LTD  

    Autoimmune vascular inflammation and oxidative stress (lipid peroxidation) are common in systemic autoimmune diseases and contribute to the oxidative modification of low-density lipoprotein (oxLDL) and oxLDL/beta 2GPI complex formation. Circulating oxLDL/beta 2GPI complexes have been detected in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The presence of antibodies to oxLDL/beta 2GPI complexes indicates that these complexes are immunogenic, and the coexistence of complexes and antibodies has pointed to an active proatherogenic role in the development of autoimmune vascular complications. Immunohistochemical staining of atherosclerotic lesions suggest that these complexes are formed in the arterial wall and released into circulation. The in vitro macrophage uptake of oxLDL/beta 2GPI complexes was significantly increased in the presence of antiphospholipid antibodies, either beta 2GPI-dependent anticardiolipin or anti-beta 2GPI antibodies, suggesting that macrophage Fe gamma receptors are involved in lipid intracellular influx and foam cell formation. These findings provide an explanation for the accelerated development of atherosclerosis seen in SLE and APS. The presence of circulation oxLDL/beta 2GPI complexes and IgG antibodies to these complexes indicate significant vascular injury and oxidative stress as well as an active role in autoimmune-mediated atherothrombosis. Lupus (2008) 17, 878 887.

    DOI: 10.1177/0961203308093553

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  • ARCHITECTONICS OF CELL SUBPOPULATIONS OF PERIPHERAL BLOOD IN PATIENTS WITH AUTOIMMUNE MYOCARDITIS: CLINICAL AND PATHOGENETIC ASPECTS 査読

    Z. S. Shogenov, N. N. Kekenadze, Se. Vorobyeva, M. P. Usik, T. Elbeik, K. A. Akhmedilova, E. E. Mamonova, E. Matsuura, M. A. Paltsev, S. V. Suchkov

    TERAPEVTICHESKII ARKHIV80 ( 12 ) 23 - 28   2008年

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    記述言語:ロシア語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IZDATELSTVO MEDITSINA  

    Aim. To compare the most significant architectonic parameters of peripheral blood cell subpopulations in patients with different variants of an autoimmune myocarditis (AIM) course and their clinical value in therapeutic practice.
    Material and methods. Blood cell subpopulations were studied with flow cytometry in 99 blood samples from patients having different AIM variants and myocardiosclerosis as well as in 40 healthy donors.
    Results. Severe (malignant) AIM was characterized by growing indices of T-/B lymphocyte activation, expression of activation markers on the cells of both differentiation lines, disproportions in composition of subpopulations of the immunoregulatory cells, parallel rise in specific weight of dendritic cells, reduced intensity of apoptosis of autoreactive T-lymphocytes. In benign AIM marked immunopathology was not found. This group can be considered as a separate variant of AIM course necessitating an individual approach to planning pathogenetically sound therapeutic and rehabilitation measures.
    Conclusion. The study of activation markers expression on peripheral blood cells is superior to the study of endomyocardial biopsies providing a non-invasive method of immunodiagnosis.

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  • 自己免疫・感染免疫が惹起する動脈硬化 招待

    松浦栄次

    Priming Biomedicine3   1 - 11   2008年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Excessive exposure to anionic surfaces maintains autoantibody response to β2-glycoprotein I in patients with antiphospholipid syndrome. 査読

    Yamaguchi Y, Seta N, Kaburaki J, Kobayashi K, Matsuura E, Kuwana M

    Blood110 ( 13 ) 4312 - 4318   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1182/blood-2007-07-100008

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  • Ecessive exposure to anionic surfaces maintains autoantibody response to β2-glycoprotein I in patients with antiphospholipid syndrome. 査読

    Yamaguchi Y, Seta N, Kaburaki J, Kobayashi K, Matsuura E, Kuwana M

    Blood110 ( 13 ) 4312 - 4318   2007年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1182/blood-2007-07-100008

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  • Antibodies against heat shock protein 60 derived from Helicobacter pylori: Diagnostic implications in cardiovascular disease 査読

    Tomoyuki Okada, Kiyoshi Ayada, Shinichi Usui, Kenji Yokata, Jinhua Cui, Yoshiro Kawahara, Tomoki Inaba, Satoshi Hirohata, Motowo Mizuno, Daisuke Yamamoto, Shozo Kusachi, Eiji Matsuura, Keiji Oguma

    JOURNAL OF AUTOIMMUNITY29 ( 2-3 ) 106 - 115   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD  

    Immune responses against heat shock protein 60 (HSP60) of pathogen-origin are thought to be defensive events which, due to molecular mimicry, misdirect to a human counterpart. Therefore, atherosclerosis may be serologically predicted by anti-HSP60 antibodies (Abs). In the present study, we analyzed the clinical prevalence of the serum IgG Abs against Helicobacter pylori (Hp)-derived HSP60 (Hp-HSP60) or its peptide fragments in patients with cardiovascular disease (CVD; n = 250), as compared to those in age- and gender-matched non-CVD patients (n = 293). Anti-Hp cell lysate Abs frequently appeared in Hp-infected patients who were not associated with CVD. In contrast, Abs against the particular amino acid sequence Hp-HSP60(II3) (II3 region, Glu(141)-Leu(160), in Hp-HSP60) predominantly appeared in CVD patients, as well as IgG anti-human HSP60 (Hu-HSP60(w)). Furthermore, neither titer of anti-Hp-HSP60(113) nor anti-Hu-HSP60(w) Abs was correlated with the levels of high sensitivity C-reactive protein (hsCRP). This data strongly suggested that IgG anti-Hp-HSP60(II3) Abs cross-reacted with Hu-HSP60(w) were independent diagnostic markers relevant to CVD. Further, the 20 amino acid residues (Glu(141)-Leu(160)) might be predominant CVD-associated epitopes that induce anti-Hu-HSP60 auto-Abs, whose location was predicted in the tertiary structure of Hu-HSP60. (c) 2007 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jaut.2007.05.004

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  • Intracellular trafficking of β2-glycoprotein I complexes with lipid vesicles in macrophages: implications on the development of antiphospholipid syndrome. 査読

    Kajiwara T, Yasuda T, Matsuura E

    J Autoimmun29 ( 2-3 ) 164 - 173   2007年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jaut.2007.07.003

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  • Cancer-associated immune-mediated syndromes: Pathogenic values. and clinical implementation 査読

    S. V. Suchkov, D. D. Petrunin, A. V. Kostalevskaya, I. A. Kachkov, T. Elbeik, E. Matsuura, M. A. Paltsev

    BIOMEDICINE & PHARMACOTHERAPY61 ( 6 ) 323 - 337   2007年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER  

    The ability of tumors to provoke formation of cancer-associated secondary immunodeficiency (CASID) with predominant suppression of CMI and cancer-associated secondary immunodeficiency with clinical autoimmunity syndrome (CASICAS) with triggering of a set of the auto-immune deviations is appearing to be a key event in the restriction of hosts' anti-tumor immunity. Earlier the existence of the above-mentioned syndromes was demonstrated in BCC and GBM patients. In order to reach a point where immunological phenotypes in GBM and BCC can be clarified clinically and, partly, pathogenically, we have conducted a series of studies of typical and atypical types of immune responsiveness in patients with GBM and BCC. For GBM and BCC three scenarios of the involvement of the immune responsiveness have been established in a series of our studies, i.e., (i) malignancy with no immunopathology, (ii) malignancy as CASID, and (iii) malignancy as CASICAS. All of those scenarios demonstrated significant differences in their immune-mediated manifestations which, in turn, were proven to reveal close associative relationships with a specific clinicopathologic type and clinical manifestations of the tumor. CASID and CASICAS share two common features, i.e., (i) signs of immunodeficiency and (ii) a tandem of the deviations within the adaptive and innate links of the host immune responsiveness. At the same time, CASID and CASICAS are distinct pathogenically and clinically, and in terms of depth of the immune deviations observed, CASID patients manifest a breakage in both links, whereas in CASICAS patients, a breakage in the adaptive link would dominate. To get these differences clarified, we summarized major types of the immune imbalances and sets of clinical and clinicopathologic manifestations to illustrate the above-mentioned features in CASID and CASICAS patients. There are distinct close correlations between clinicopathologic features of the disease course and sets of the immune-mediated imbalances in patients harboring the tumors. The latter implicates a panel of the new immuno-diagnostic and immuno-prognostic criteria for patients with solid tumors, i.e., BCC, MCC and GB, which is of great value for clinical practice. In particular, the blood levels of some of the immunocompetent cells, state of their functional activity, serum titers of the antigenic markers and auto-antibodies, apoptotic parameters, and others may be accepted as additional and clinically informative criteria to be implemented for immunological monitoring and immunotherapy of patients with solid tumors. (C) 2007 Elsevier Masson SAS. All rights reserved.

    DOI: 10.1016/j.biopha.2007.06.007

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  • Postinfectious immunodeficiency and autoimmunity: Pathogenic and clinical values and implications 査読

    Alexander N. Khitrov, Zaur S. Shogenov, Eugenia B. Tretyak, Anatoly I. Ischenko, Eiji Matsuura, Oliver Neuhaus, Mikhail A. Paltsev, Sergey V. Suchkov

    Expert Review of Clinical Immunology3 ( 3 ) 323 - 331   2007年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Autoimmunity is still a mystery of clinical immunology and medicine as a whole. The etiology and pathogenesis of autoimmune disorders remain unclear and, thus, are assessed as a balance between hereditary predisposition, triggering factors and the appearance of autoantibodies and/or self-reactive T cells. Among the immunological armamentarium, molecular mimicry, based on self-reactive T- and B-cell activation by cross-reactive epitopes of infectious agents, is of special value. Hypotheses regarding the possible involvement of molecular mimicry in the development of postinfectious autoimmunity are currently very intriguing. They provide new approaches for identifying etiological agents that are associated with postinfectious autoimmunity, paired microbial- and tissue-linked epitopes targeted for autoimmune reaction determination, postinfectious autoimmunity pathogenesis recognition and specific prevention, and therapy for autoimmune disorder development. © 2007 Future Drugs Ltd.

    DOI: 10.1586/1744666X.3.3.323

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  • The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis 査読

    Masako Tabuchi, Katsumi Inoue, Hitomi Usui-Kataoka, Kazuko Kobayashi, Misako Teramoto, Koji Takasugi, Kenichi Shikata, Masahiro Yamamura, Kenji Ando, Keiichiro Nishida, Junko Kasahara, Noriaki Kume, Luis R. Lopez, Kazuaki Mitsudo, Masakiyo Nobuyoshi, Tatsuji Yasuda, Toru Kita, Hirofumi Makino, Eiji Matsuura

    JOURNAL OF LIPID RESEARCH48 ( 4 ) 768 - 781   2007年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC  

    C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with beta 2-glycoprotein I (beta 2GPI), implicating oxLDL/P2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascular disease. In this study, we investigated the interaction of CRP with oxLDL/beta 2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus (DM). CRP/oxLDL/R2GPI complexes were predominantly found in sera of DM patients with atherosclerosis. In contrast, noncomplexed CRP isoforms were present in sera of patients with acute/chronic inflammation, i.e., various pyrogenic diseases, rheumatoid arthritis (RA), and DM. Immunohistochemistry staining colocalized CRP and beta 2GPI together with oxLDL in carotid artery plaques but not in synovial tissue from RA patients, strongly suggesting that complex formation occurs during the development of adierosclerosis. Serum levels of CRP correlated with soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and oxLDL/beta 2GPI complexes correlated with total cholesterol and hemoglobin Al c. Thus, the generation of CRP/oxLDL/beta 2GPI complexes seems to be associated with arterial inflammation, hyperglycemia, and hypercholesterolemia. CRP/oxLDL/R2GPI complexes can be distinguished from pyrogenic noncomplexed CRP isoforms and may represent a more specific and predictive marker for atherosclerosis.

    DOI: 10.1194/jlr.M600414-JLR200

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  • β2-Glycoprotein I autoantibodies 査読

    Eiji Matsuura, Ken J. Dier, Luis R. Lopez

    Autoantibodies   687 - 693   2007年

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    記述言語:英語   掲載種別:論文集(書籍)内論文   出版者・発行元:Elsevier Inc.  

    Elevated serum levels of antiphospholipid antibodies, thrombosis and/or pregnancy morbidity (miscarriages, recurrent fetal loss) are the major features of the antiphospholipid syndrome (APS). Antiphospholipid antibodies are a heterogeneous family of autoantibodies thought itplays an active role in the development of thrombosis in patients with APS. These antibodies react with negatively charged phospholipids, phospholipid/protein complexes, and certain plasma proteins presented on suitable surfaces (that is, activated cell membranes, oxygenated polystyrene). Most antiphospholipid antibodies from APS patients require the presence of certain plasma proteins for optimal phospholipid binding activity. β2-glycoprotein I (β2GPI), a phospholipid-binding protein, is now recognized as the most clinically relevant antigenic target for antiphospholipid antibodies. Antiβ2GPI antibodies are more specific for thrombosis (and APS) than anticardiolipin (aCL) antibodies. Recent prospective studies have shown that β2GPI-dependent aCL and antiβ2GPI antibodies were significant predictors of arterial thrombosis (myocardial infarction and stroke) in men. β2GPI has natural anticoagulant properties but it may also bind to oxidized low-density lipoprotein (oxLDL) to neutralize its pro-inflammatory effects and possibly to promote its clearance. Circulating oxLDL/β2GPI complexes are immunogenic and anti-oxLDL/β2GPI antibodies accelerate the development of autoimmune-mediated thrombosis and atherosclerosis. © 2007 Elsevier Inc. All rights reserved.

    DOI: 10.1016/B978-044452763-9/50089-5

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  • Distinguished effects of antiphospholipid antibodies and anti-oxidized LDL antibodies on oxidized LDL uptake by macrophages 査読

    K. Kobayashi, K. Tada, H. Itabe, T. Ueno, P-H Liu, A. Tsutsumi, M. Kuwana, T. Yasuda, Y. Shoenfeld, P. G. de Groot, E. Matsuura

    LUPUS16 ( 12 ) 929 - 938   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SAGE PUBLICATIONS LTD  

    Several interpretations have been made regarding the specificity of antiphospholipid antibodies and antibodies against oxidized low-density lipoprotein (oxLDL), but these are still controversial. In the present study, we delineated specificity of these two types of antibodies and analyzed their regulatory effect on oxLDL and/or beta(2)-glycoprotein I (beta(2)GPI) binding to macrophages. Scavenger receptormediated binding of oxLDL (or its beta(2)GPI complexes) to macrophages was observed and the binding was partly prevented by beta(2)GPI. The IgG monoclonal anti-beta(2)GPI antibody (WB-CAL-1), which was derived from NZW X BXSB F1 mouse (a model of antiphospholipid syndrome), significantly increased the oxLDL/beta(2)GPI binding to macrophages. In contrast, IgM anti-oxLDL natural antibody, EO6 (derived from apoe(-1-) mouse), prevented the binding. Different antigenic specificity of these antibodies to oxLDL and its beta(2)GPI complexes was also confirmed in TLC-ligand blot and ELISA. Thus, IgG anti-beta(2)GPI autoantibodies contribute to lipid metabolism (housekeeping of oxLDL by macrophages) whereas IgM natural anti-oxLDL antibodies may protect against atherogenesis. In addition, in vitro data suggest that relatively high dose of intravenous immunoglobulin preparations (mainly contain IgG anti-oxLDL antibodies) might also prevent atherogenesis by inhibiting the oxLDL binding to macrophages.

    DOI: 10.1177/0961203307084170

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  • Chronic infections and atherosclerosis 査読

    Kiyoshi Ayada, Kenji Yokata, Kazuko Kobayashi, Yehuda Shoenfeld, Eiji Matsuura, Keiji Oguma

    AUTOIMMUNITY, PT D1108   594 - 602   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Immunoinflammatory processes due to chronic infection are thought to be one of the definitive atherogenetic processes. Especially, anti-heat shock protein antibodies have been related to the prevalence of disease such as coronary artery disease or cerebral infarction, etc., resulted from atherosclerosis. Furthermore, the presence of HSP60specific T lymphocytes in circulation may increase the risk of atherosclerosis. We have recently demonstrated the evidences that Helicobacter pylori infection induced atherosclerosis in apoe(+/-)Idlr(+/-) mice and that Hp-anti-heat-shock protein specific Th1-dominant immune responses had a major involvement in the progression of atherosclerosis. These cellular immune responses caused autoimmunity against endogenous HSP60 (expressed on the stressed cells of vascular endothelium), due to the molecular mimicry. Therefore, an appropriate treatment with antibiotics or with anti-HSP60 antibodies, which regulates the Th1 induction, could sufficiently reduce the progression of atherosclerosis.

    DOI: 10.1196/annals.1422.062

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  • Determination of oxidized low-density lipoprotein (oxLDL) versus oxLDL/β2GPI complexes for the assessment of autoimmune-mediated atherosclerosis. 査読

    Lopez LR, Hurley BL, Buckner T, Kobayashi K, Matsuura E

    Ann NY Acad Sci1109   303 - 310   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1196/annals.1398.036

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  • Oxidation of LDL and its clinical implication.

    Matsuura E, Hughes GRV, Khamashta MA

    Autoimmun Rev7   558 - 566   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Antiphospholipid antibodies patients with coronary artery disease - New cardiac risk factors? 査読

    Tom P. Greco, Ann Marie Conti-Kelly, Eiji Matsuura, Tom Greco, Ken J. Dier, Gregory Svanas, Robin Doyle, Luis R. Lopez

    AUTOIMMUNITY, PT D1108   466 - 474   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Antiphospholipid antibodies (aPL) have been implicated in the pathogenesis of coronary artery disease (CAD). We evaluated the presence of aPL in patients with chest pain/acute coronary syndromes (ACS) to determine if aPL were associated with the presence and severity of CAD, adverse outcomes, and other coronary risk factors. Patients with chest pain/ACS were evaluated for aPL prior to diagnostic and therapeutic investigations. Coronary angiograms were graded according to the severity of disease. Risk factors, including family histories, were assessed and patients were followed for adverse outcomes. To date, 232 patients (116 M, 116 F, mean age 63 years) with a mean follow-up of 9 months were studied. Thirty-seven percent (86/232) were positive for one or more aPL. More women, 49/86 (57%), were aPL positive versus men, 37/86 (43%). The presence of aPL appeared associated with both presence and severity of CAD (P = 0.176 women; P = 0.163 men). In patients undergoing procedures (angioplasty, stent, bypass), aPL was significantly associated with both an increase in adverse cardiac outcomes (P = 0.045) and extracardiac thrombotic events (P = 0.033). Anti-beta 2 glycoprotein-1 (a beta 2GP1) was the most frequent aPL, occurring in 68.5% of aPL-positive patients with CAD. Anticardiolipin antibody (aCL) occurred in only 7.4%. IgM isotypes were the most frequent for all categories of aPL (range 55-90%). Family history of antiphospholipid syndrome (APS)-related events was more significant in aPL-positive than aPL-negative individuals (P = 0.027).

    DOI: 10.1196/annals.1422.049

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  • Subclinical atherosclerosis in primary antiphospholipid syndrome 査読

    Annamaria Margarita, Joana Batuca, Giovanna Scenna, Jose' Delgado Alves, Louis Lopez, Luigi Iannaccone, Eiji Matsuura, Paul R. J. Ames

    AUTOIMMUNITY, PT D1108   475 - 480   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    To test the atherosclerosis hypothesis in primary antiphospholipid syndrome (PAPS) we measured intima media thickness (IMT) of carotid arteries and other cardiovascular risk factors in 44 patients with PAPS (mean age 35 +/- 12 years), in 25 patients with inherited thrombophilia (mean age 40 +/- 10 years), and in 34 normal controls (mean age 38 +/- 11 years). The frequency of smoking, hypertension, and dyslipidemia was similar across groups. IMT was almost similar across groups at age groups below 40 years but IMT was greater in PAPS than controls at the common carotid (P = 0.01), at the bifurcation (P = 0.003), and at the internal carotid (P = 0.005) in the age group over 40 years. Atherosclerosis is a possibility in PAPS patients in their fourth decade of life or older.

    DOI: 10.1196/annals.1422.050

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  • Atherogenic Antiphospholipid antibodies in Antiphospholipid syndrome 査読

    Kazuko Kobayashi, Luis R. Lopez, Eiji Matsuura

    AUTOIMMUNITY, PT D1108   489 - 496   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL PUBLISHING  

    Macrophage uptake of oxidized LDL (oxLDL) plays a critical role in early stages of atherosclerosis. We previously reported that oxLDL forms stable complexes with beta(2)-glycoprotein I (beta(2)GPI), and that these complexes were frequently present in the sera of patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). oxLDL/beta(2)GPI complexes were shown to be antigenic targets for autoantibodies present in APS. To understand the role of autoantibodics in accelerated atherosclerosis of SLE and APS, we investigated the binding characteristics of beta(2)GPI and oxLDL to mouse macrophages, and the effect of anti-p2GPI and anti-oxLDL autoantibodies on this macrophage binding. IgM anti-oxLDL antibody (derived from Apoe(-/-) mouse) showed inhibitory effect on oxLDL binding to macrophages. Although beta(2)GPI partly inhibited oxLDL binding to macrophages, IgG anti-beta(2)GPI antoantibody (derived from APS model mouse) showed pro-atherogenic property by promoting the binding of oxLDL/beta(2)GPI to macrophages.

    DOI: 10.1196/annals.1422.052

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  • Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia 査読

    Kumiko Hirokoshi, Yohei Maeshima, Kazuko Kobayashi, Eiji Matsuura, Hitoshi Sugiyama, Yasushi Yamasaki, Hisashi Masuyama, Yuji Hiramatsu, Hirofumi Makino

    NEPHRON CLINICAL PRACTICE106 ( 1 ) C43 - C50   2007年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Background: An imbalance of angiogenesis-associated factors may predispose to preeclampsia. Here, we determined the ratio of serum concentration of soluble fms-like tyrosine kinase 1 (sFlt-1), a natural inhibitor of pro-angiogenic vascular endothelial growth factor (VEGF) relative to angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of VEGF, in women with preeclampsia. Methods: The levels of serum sFlt-1 and Ang-2 were measured by enzyme-linked immunosorbent assay. Results: Significant decrease of serum Ang-2 and the increase of sFlt-1 were observed in women with preeclampsia as compared to healthy pregnant women. The serum sFlt-1/Ang-2 ratio was strikingly increased in preeclamptic women in contrast to healthy pregnant women exhibiting lower value similar to non-pregnant women. The serum sFlt1 concentrations tended to positively correlate with mean blood pressure (BP) in preeclamptic women, but not in healthy pregnant women. A cut-off value > 0.25 in the serum sFlt-1/Ang-2 ratio showed 87.1% sensitivity and 82.8% specificity in differentiating preeclamptic women from healthy pregnant women. Conclusion: The serum sFlt-1/Ang-2 ratio is significantly elevated in preeclamptic women as compared to healthy pregnant women. Remarkable difference of sFlt-1/Ang-2 ratio between these two groups with excellent specificity and sensitivity suggests the clinical usefulness of the serum sFlt-1/Ang-2 ratio in diagnosing and potentially predicting the onset of preeclampsia. Copyright (c) 2007 S. Karger AG, Basel.

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  • Accelerated atheroma in the antiphospholipid syndrome 査読

    Eiji Matsuura, Kazuko Kobayashi, Masako Tabuchi, Luis R. Lopez

    RHEUMATIC DISEASE CLINICS OF NORTH AMERICA32 ( 3 ) 537 - +   2006年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

    Increased cardiovascular morbidity and mortality due to the premature or accelerated development of atherosclerosis has been reported in patients with systemic autoimmune diseases such as a systemic lupus erythematosus (SLE) [1-3]. These findings motivated a great deal of research into the role of autoimmunity in atherogenesis. The relationship of cholesterol metabolism to atherosclerosis has been well established. However, the participation of newer inflammatory and immunologic mechanisms are emerging as relevant factors for the initiation and progression of atherosclerotic lesions. The oxidative modification of low-density lipoprotein (oxLDL) with the development of autoantiboclies to oxLDL have been identified as key proatherogenic events that accelerate the formation of macro phage-derived foam cells and atherosclerotic lesions [4-7]. Many of the life-threatening clinical complications presented by patients with antiphospholipid syndrome (APS) involve both the venous and arterial blood vessels. Since the original description of APS, much attention has been directed toward the basic and clinical mechanisms of vascular injury and thrombosis. The venous and arterial thromboembolic events of APS are associated with elevated serum levels of antiphospholipid antibodies, and frequently observed in the context of an autoimmune disorder [8,9]. The exact mechanism by which antiphospholipid antibodies promote thrombosis is not yet completely understood. However, it is widely accepted that these antibodies play a direct pathogenic role in the development of thrombosis. Venous thrombosis is the most common vascular event; however, one of three APS patients presents arterial thrombosis (myocardial infarction, cerobrovascular accident, angina, and suggest that beta 2-glycoprotein I (beta 2GPI) is the major antigenic target for antiphospholipid antibodies, and thought to play a central role in the development of the clinical complications of APS [13-16]. Further, anti-beta 2GPI antibodies have been associated with the history of arterial thrombosis [17-19]. OxLDL is the principal lipoprotein found in atherosclerotic lesions by immunohistochemical analysis, and it colocalizes with beta 2GPI, immunoreactive CD4 and CD8 lymphocytes and immunoglobulins [20,21]. These findings further suggested an active role of antiphospholipid antibodies in atherogenesis. OxLDL binds to beta 2GPI in vitro, and circulating OxLDL/ beta 2GPI complexes were demonstrated in patients with various systemic autoimmune and chronic inflammatory diseases, such as SLE, APS, chronic renal disease, diabetes mellitus, and in some patients with acute myocardial infarction [22-25]. IgG antibodies to OxLDL/beta 2GPI complexes were only detected in patients with SLE and APS, and were strongly associated with arterial thrombosis [26]. In vitro experiments have shown that OxLDL/beta 2GPI complexes were more rapidly internalized by macrophages when anti-beta 2GPI antibodies were present, suggesting the participation of Fey receptors [23-25]. Thus, circulating IgG immune complexes containing oxLDL and beta 2GPI may be atherogenic.

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  • Antibodies against β2-glycoprotein I complexed with an oxidised lipoprotein relate to intima thickening of carotid arteries in primary antiphospholipid syndrome. 査読

    Ames PR, Delgado Alves J, Lopez LR, Gentile F, Margarita A, Pizzella L, Batuca J, Scenna G, Brancaccio V, Matsuura E

    Clin Develop Immunol13 ( 1 ) 1 - 9   2006年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/17402520600554930

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  • Roles of interaction between β2-glycoprotein I and plasma lipoproteins in atherosclerosis. 査読

    Matsuura E, Kobayashi K, Tabuchi M, Lopez LR

    Prog Lipid Res45   466 - 486   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • IVIG and atherosclerosis. 査読

    Matsuura E, Kobayashi K, Inoue K, Shoenfeld Y

    Clin Rev Allergy Immunol29   311 - 319   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Oxidized low-density lipoprotein and β2-glycoprotein I in patients with systemic lupus erythematosus and increased carotid intima-media thickness: implications in autoimmune-mediated atherosclerosis. 査読

    Lopez LR, Salazar-Paramo M, Palafox-Sanchez C, Hurley BL, Matsuura E, Garcia-De La Torre I

    Lupus15 ( 2 ) 80 - 86   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1191/0961203306lu2267oa

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  • Atherogenic oxidized low-density lipoprotein/β2-glycoprotein I (oxLDL/β2GPI) complexes in patients with systemic lupus erythematosus and antiphospholipid syndrome. 査読

    Matsuura E, Kobayashi K, Hurley BL, Lopez LR

    Lupus15 ( 7 ) 478 - 483   2006年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1191/0961203306lu2337oa

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  • Intravenous immunoglobulin and atherosclerosis 査読

    E Matsuura, K Kobayashi, K Inoue, Y Shoenfeld

    CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY29 ( 3 ) 311 - 319   2005年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HUMANA PRESS INC  

    Several inflammatory and immunological factors have been established as important contributors to atherogenesis. Among these, oxidized low-density lipoprotein (oxLDL) play a central role in the initiation and progression of atherosclerotic lesions. In atherosclerotic lesions, oxLDL was also found to co-localize with beta(2)-glycoprotein I (beta(2)-GPI). Immunoglobulin (Ig)G autoantibodies against beta(2)-GPI complexes with oxLDL are pro-atherogenic because they increase uptake of the complexes by macrophages. In contrast, IgM natural anti-oxLDL antibodies derived from atherosclerosis-prone apolipoprotein E (ApoE) deficient mice reduced incidence of atherosclerosis. Such anti-oxLDL antibodies have been found in humans, and the accumulating evidences seem to support the idea that anti-oxLDL antibodies have a protective role for atherogenesis. Intravenous immunoglobulins (IVIgs) contain natural anti-oxLDL antibodies and infusion of IVIg into ApoE-deficient mice has been reported to decrease atherosclerosis. The anti-atherogenic property of IVIg may be derived from non-antigen-specific antibody binding to FC gamma receptors, which blocks foam cell formation of macrophages. Several other possible mechanisms are also discussed.

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  • Antigenic structures recognized by anti-β2-glycoprotein I auto-antibodies. 査読

    Kasahara H, Matsuura E, Kaihara K, Yamamoto D, Kobayashi K, Inagaki J, Ichikawa K, Tsutsumi A, Yasuda S, Atsumi T, Yasuda T, Koike T

    Int Immunol17 ( 12 ) 1533 - 1542   2005年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/intimm/dxh330

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  • Accelerated atherosclerosis in autoimmune rheumatic diseases 査読

    Y Shoenfeld, R Gerli, A Doria, E Matsuura, MM Cerinic, N Ronda, LJ Jara, M Abu-Shakra, PL Meroni, Y Sherer

    CIRCULATION112 ( 21 ) 3337 - 3347   2005年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1161/CIRCULATIONHA.104.507996

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  • Increase of serum angiopoietin-2 during pregnancy is suppressed in women with preeclampsia 査読

    K Hirokoshi, Y Maeshima, K Kobayashi, E Matsuura, H Sugiyama, Y Yamasaki, H Masuyama, Y Hiramatsu, H Makino

    AMERICAN JOURNAL OF HYPERTENSION18 ( 9 ) 1181 - 1188   2005年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Background: Numerous recent reports demonstrated that changes in serum levels of angiogenesis-related factors were associated with preeclampsia. Here, we determined the serum concentration of angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of angiogenic stimuli such as vascular endothelial growth factor (VEGF), in women with preeclampsia.
    Methods: The levels of serum Ang-2 and Tie-2, a receptor for Ang-1 expressed on endothelial cells, were determined by enzyme-linked immunosorbent assay.
    Results: The concentrations of serum Ang-2 were significantly elevated in healthy pregnant women (18.9 ng/ mL) as compared to nonpregnant women or women in postpartum period. Increase in the levels of serum Ang-2 was significantly suppressed in preeclamptic women (4.5 ng/mL). The serum Ang-2 concentrations inversely correlated with gestational age in healthy pregnant women, but not in preeclamptic women. The serum Ang-2 concentrations positively correlated with placental weight or mean blood pressure (BP) in healthy pregnant women,but not in preeclamptic women. The serum Ang-2 concentrations inversely correlated with proteinuria in preeclamptic women. The serum concentrations of Tie-2 were riot significantly different between preeclamptic and nonpreeclamptic women.
    Conclusions: These results suggest the potential requirement of circulating Ang-2 in proper formation of placental vasculatures during pregnancy. Although we cannot exclude the possibility that suppression in the increase of serum Ang-2 levels during pregnancy in preeclampsia as a consequence rather than a cause, measurement of serum Ang-2 concentration in pregnant women may serve as a useful marker in the diagnosis and potentially in predicting subsequent development of preeclampsia.

    DOI: 10.1016/j.amjhyper.2005.03.745

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  • Research around β2-glycoprotein I. a major target for antiphospholipid antibodies. 査読

    Atsumi T, Amengual O, Yasuda S, Matsuura E, Koike T

    Autoimmun38 ( 5 ) 377 - 381   2005年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/08916930500124312

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  • Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: Identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid 査読

    K Amano, PSC Leung, R Rieger, C Quan, XB Wang, J Marik, YF Suen, MJ Kurth, MH Nantz, AA Ansari, KS Lam, M Zeniya, E Matsuura, RL Coppel, ME Gershwin

    JOURNAL OF IMMUNOLOGY174 ( 9 ) 5874 - 5883   2005年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC IMMUNOLOGISTS  

    Emerging evidence has suggested environmental factors as causative agents in the pathogenesis of primary biliary cirrhosis (PBC). We have hypothesized that in PBC the lipoyl domain of the immunodominant E2 component of pyruvate dehydrogenase (PDC-E2) is replaced by a chemical xenobiotic mimic, which is sufficient to break self-tolerance. To address this hypothesis, based upon our quantitative structure-activity relationship data, a total of 107 potential xenobiotic mimics were coupled to the lysine residue of the immunodominant 15 amino acid peptide of the PDC-E2 inner lipoyl domain and spotted on microarray slides. Sera from patients with PBC (n = 47), primary sclerosing cholangitis (n = 15), and healthy volunteers (n = 20) were assayed for Ig reactivity. PBC sera were subsequently absorbed with native lipoylated PDC-E2 peptide or a xenobiotically modified PDC-E2 peptide, and the remaining reactivity analyzed. Of the 107 xenobiotics, 33 had a significantly higher IgG reactivity against PBC sera compared with control sera. In addition, 9 of those 33 compounds were more reactive than the native lipoylated peptide. Following absorption, 8 of the 9 compounds demonstrated cross-reactivity with lipoic acid. One compound, 2-octynoic acid, was unique in both its quantitative structure-activity relationship analysis and reactivity. PBC patient sera demonstrated high Ig reactivity against 2-octynoic acid-PDC-E2 peptide. Not only does 2-octynoic acid have the potential to modify PDC-E2 in vivo but importantly it was/is widely used in the environment including perfumes, lipstick, and many common food flavorings.

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  • Characterization of a murine anti-laminin-1 monoclonal antibody (AK8) produced by immunization with mouse-derived laminin-1 査読

    Akane Kondo, Junko Inagaki, Kazuko Kobayashi, Hideo Tsukamoto, Daisuke Yamamoto, Mikiya Nakatsuka, Nobuharu Suzuki, Motoyoshi Nomizu, Satoshi Amano, Hidehiko Matsubayashi, Tatsuji Yasuda, Luis R. Lopez, Yehuda Shoenfeld, Tsunehisa Makino, Eiji Matsuura

    Clinical and Developmental Immunology12 ( 1 ) 67 - 73   2005年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Laminin-1 is a structural glycoprotein that forms an integral part of the scaffolding of basement membranes, and plays an important role during embryonic development. We have recently demonstrated a significant association between anti-laminin-1 antibodies (Abs) and reproductive failure, such as recurrent spontaneous abortions and infertility-associated endometriosis in both human and mouse studies. In the present study, we established an IgM (μ, κ) monoclonal anti-laminin-1 Ab (AK8) by immunizing mice with mouse Engelbreth-Holm-Swarm sarcoma (EHS)-derived laminin-1. The AK8 monoclonal antibody (mAb) reacted with particular peptide sequences from the globular G domain of mouse laminin-α1 chain of using ELISA and Western blot techniques. The peptide tertiary structure of the epitope recognized by AK8 mAb was predicted using eight synthesized domain peptide sequences and three consensus sequences obtained by phage displayed random peptide library. Basement membranes of endometrium of pregnant mice and humans were immunostained with AK8 mAb. Thus, AK8 mAb recognized a common structure present in the G domain of the laminin-α1 chain in both mice and humans. The passive immunization of mice with AK8 mAb may represent a suitable animal model for anti-laminin-1 Ab-mediated reproductive failure. © 2005 Taylor &amp
    Francis Group Ltd.

    DOI: 10.1080/17402520400014168

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  • Binding of β2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells. 査読

    Kuwana M, Matsuura E, Kobayashi K, Okazaki Y, Kaburaki J, Ikeda Y, Kawakami

    Blood105 ( 4 ) 1552 - 1557   2005年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1082/blood-2004-08-3145

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  • Significance of valine/leucine247 polymorphysm of β2-glycoprotein I in antiphospholipid syndrome: increased reactivity of anti-β2-glycoprotien I autoantibodies to the valine247 β2-glycoprotein I variant.

    Yasuda S, Atsumi T, Matsuura E, Kaihara K, Yamamoto D, Ichikawa K, Koike T

    Arthritis Rheum52 ( 1 ) 212 - 218   2005年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/art.20741

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  • Lymphocyte subpopulations and intima media thickness in primary antiphospholipd syndrome 査読

    PRJ Ames, C Tommasino, G Fossati, E Matsuura, A Margarita, A Saulino, L Lopez, G Scenna, Brancaccio, V

    LUPUS14 ( 10 ) 809 - 813   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HODDER ARNOLD, HODDER HEADLINE PLC  

    The aim of this study was to evaluate a possible association between lymphocyte subsets and intima media thickness (IMT) of carotid arteries in primary antiphospholipid syndrome (PAPS). We used a cross-sectional study on PAPS patients (n = 18) and healthy controls (n = 16). IgG anti-cardiolipin antibody (aCL), IgG anti-beta(2)glycoprotein-I (anti-beta(2)GPI), IgG anti-beta(2)glycoprotein-I complexed to oxidized low-density lipoprotein (oxLDL) and to a specific oxidized moiety of LDL (oxLig1), and beta(2)GPI-oxLDL were measured by ELISA. Lymphocyte immunophenotyping was performed using pairs of monoclonal antibodies directly labelled with fluorescein isothiocyanate, or phycoerythrin or phycoerythrin-Texas-red-X. Intima media thickness (IMT) of carotid arteries was determined by high-resolution sonography. Total peripheral blood lymphocytes did not differ between PAPS and controls. Memory CD4+/CD45RO + T cells were lower in PAPS than controls (P = 0.0007) as well as CD 16+ 56+ natural killer cells (P = 0.02), In PAPS memory T CD45RO + cells positively correlated with IgG anti-beta(2)GPI-oxLig1 (P = 0.002) and to IMT of carotid arteries (common carotid P = 0.02, bifurcation P = 0.007). Naive CD4+ /CD45RA+ T cells inversely correlated with beta 2GPI-oxLDL (P = 0.009). The relation between IgG anti-beta 2GPI-oxLig1 and IMT of carotid arteries with memory CD45RO + T lymphocytes suggests a role for the latter in PAPS related atherogenesis. Lupus (2005) 14, 809-813.

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  • The role of innate and adaptive immunity to oxidized low-density lipoprotein in the development of atherosclerosis

    K Kobayashi, LR Lopez, Y Shoenfeld, E Matsuura

    AUTOIMMUNE DISEASES AND TREATMENT: ORGAN-SPECIFIC AND SYSTEMIC DISORDERS1051   442 - 454   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NEW YORK ACAD SCIENCES  

    Atherosclerosis is a chronic inflammatory process of the arterial wall associated with systemic and local immune responses to various antigens, oxidized low-density lipoprotein (oxLDL) being the most significant. Both IgM and IgG antibodies to oxLDL are produced during atherosclerosis. Some studies have shown that elevated levels of antibody to oxLDL correlate with the degree of atherosclerosis. Other studies reported that immunization of experimental animals with oxLDL induces high levels of antibodies to oxLDL, with decreased atherosclerosis, suggesting that the immune response to oxLDL may be antiatherogenic. The accelerated development of atherosclerosis has been observed in patients with systemic autoimmune diseases. In patients with antiphospholipid syndrome (APS), beta 2-glycoprotein I (beta 2GPI) is a major antigenic target for anticardiolipin antibodies (aCLs). We recently reported that oxLDL interacts with beta 2GPI via oxLDL-derived specific ligands, such as 7-ketocholesteryl-9-caboxynonanoate (oxLig-1) to form complexes. In vitro, anti-beta 2GPI autoantibodies bind to oxLDL/beta 2GPI complexes that are actively taken up by macrophages via Fc gamma receptors. Circulating oxLDL/beta 2GPI complexes were detected in patients with systemic lupus erythematosus (SLE) and APS, at higher levels than in healthy individuals. Autoantibodies against these complexes were also present; however, IgG anti-oxLig-1/beta 2GPI antibody levels in SLE patients with APS were significantly higher than those in SLE patients without APS and those in healthy individuals.

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  • OxLDL/β2GPI complex: role in atherosclerosis. 査読

    Matsuura E, Kobayashi K, Inoue K, Lopez LR, Shoenfeld Y

    Lupus14 ( 9 ) 736 - 741   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1191/0961203305lu2211oa

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  • From animal models to human genetics: Research on the induction and pathogenicity of autoantibodies 査読

    Karsten Conrad, Michael P. Bachmann, Eiji Matsuura, Yehuda Shoenfeld

    Autoimmunity Reviews4 ( 3 ) 178 - 187   2005年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:Elsevier  

    The revolutionary techniques of modern molecular and cellular biology enhance almost daily our knowledge of immunity and autoimmunity in men and experimental animals. Our fragmentary puzzle of the immune system is going to form a fascinating picture of a masterpiece of evolution. Although many of these aspects were achieved by analysis of human body fluids and tissues, the etiopathogenesis of autoimmune diseases cannot readily be analyzed without appropriate animal models. Therefore, the 7th Dresden Symposium on Autoantibodies has focused on experimental autoimmune models. The 295 attendants of the symposium listened to and discussed about the pathogenesis and therapy of autoimmunity in experimental mouse models, natural and pathogenic autoantibodies, molecular mechanisms of xenobiotic-induced autoimmunity, the genetic background of autoimmune diseases, novel autoantibodies and their pathogenic and/or clinical relevance, autoantibodies in systemic and neurological diseases, the occurrence and measurement of therapy-induced antibodies and methodical aspects as well as novel diagnostic strategies including multiplex assays for autoantibody profiling. Those who are interested to read the full length articles are referred to the book published in parallel to this meeting ([Conrad K, Bachmann MP, Chan EKL, Fritzler MJ, Humbel RL, Sack U, Shoenfeld Y, editors. From animal models to human genetics: research on the induction and pathogenicity of autoantibodies, Report on the 7th Dresden Symposium on Autoantibodies held in Dresden on September 1-4, 2004. Germany: Pabst Science Publishers
    2004.]
    www.pabst-publishers.de). © 2004 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.autrev.2004.10.001

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  • Oxidized low-density lipoprotein/β2-glycoprotein I complexes and autoantibodies in patients with type 2 diabetes mellitus. 査読

    Lopez LR, Hurley BL, Simpson DF, Matsuura E

    Ann NY Acad Sci1051   97 - 103   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1196/annals.1361.050

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  • OxLDL/β2GPI complexes and autoantibodies in patients with systemic lupus erythematosus, systemic sclerosis and antiphospholipid syndrome: pathogenic Implications for vascular involvement. 査読

    Lopez LR, Simpson DF, Hurley BL, Matsuura E

    Ann NY Acad Sci1051   313 - 322   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1196/annals.1361.073

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  • Pregnancy loss and endometriosis - Pathogenic role of anti-laminin-1 autoantibodies 査読

    J Inagaki, A Kondo, LR Lopez, Y Shoenfeld, E Matsuura

    AUTOIMMUNE DISEASES AND TREATMENT: ORGAN-SPECIFIC AND SYSTEMIC DISORDERS1051   174 - 184   2005年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NEW YORK ACAD SCIENCES  

    Laminin-1 is a major multifunctional glycoprotein that forms an integral part of the scaffolding network of basement membranes, and is the earliest synthesized component during embryogenesis. This protein (alpha 1 beta 1 gamma 1) plays an important role in basement membrane assembly and epiblast differentiation during embryonic development. Anti-laminin-1 autoantibodies are known to cause infertility and recurrent spontaneous abortion in animals. Recently, we reported that the presence of IgG anti-laminin-1 antibodies (Abs) in the blood is significantly associated with recurrent first-trimester miscarriages and subsequent negative pregnancy outcomes. Interestingly, these antibodies are also strongly associated with infertility, especially infertility caused by endometriosis. Laminin-alpha 1, laminin-beta 1, and laminin-gamma 1 mRNAs were also detected in 90% of endometriotic lesions, and all laminin-alpha 1, laminin-beta 1, and laminin-gamma 1 chains were localized to the basement membranes of glandular epithelium in endometriotic peritoneal lesions. ELISA showed specific reactivity of the autoantibodies to a particular region of the laminin-1 molecule, that is, the alpha 1 chain G domain. IgM monoclonal anti-laminin-1 Abs, which we recently established, also recognized the G domain and cross-reacted with human alpha 1 chain located in the basement membrane of the glandular epithelium of human endometrium. We also established an animal model that produced high titers of anti-laminin-1 Abs after immunization with mouse laminin-1. Anti-laminin-1 Abs from the immunized mice caused a higher fetal resorption rate with lower embryonic and placental weights. Thus, anti-laminin-1 Abs may be important in the development of autoimmune-mediated reproductive failures, and the assessment of the such antibodies may provide a novel means for noninvasive diagnosis of endometriosis.

    DOI: 10.1196/annals.1361.059

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  • Are anti-oxidized low-density lipoprotein antibodies pathogenic or protective? 査読

    Y Shoenfeld, RH Wu, LD Dearing, E Matsuura

    CIRCULATION110 ( 17 ) 2552 - 2558   2004年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    DOI: 10.1161/01.CIR.0000143225.07377.EA

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  • Anti-laminin-1 autoantibodies, pregnancy loss and endometriosis 査読

    Junko Inagaki, Akane Kondo, Luis R. Lopez, Yehuda Shoenfeld, Eiji Matsuura

    Clinical and Developmental Immunology11 ( 3-4 ) 261 - 266   2004年9月

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    Laminin-1 is a major component and multifunctional glycoprotein of basement membranes that consists of three different subunits, α1, β1 and γ1 chains. It is the earliest synthesized network-forming protein during embryogenesis and plays an important role in embryonic development, embryonic implantation and placentation. We have recently shown that IgG anti-laminin-1 antibodies were significantly associated with recurrent first-trimester miscarriages and with subsequent pregnancy outcome. Interestingly, these antibodies were also observed in patients with endometriosis-associated infertility but not in patients with other causes of infertility, including tubal factors, hormonal and uterine abnormalities. Laminin-α1, -β1 and -γ1 mRNAs have been detected in 90% of endometriotic lesions and all laminin-α1, -β1 and -γ1 chains were localized in the basement membranes of glandular epithelium in endometriotic peritoneal lesions. Western blot analysis showed that anti-laminin-1 antibodies from those patients reacted with all laminin-1's chains. ELISA also confirmed that one of the target epitopes for these antibodies was located in a particular region of the laminin-1 molecule, i.e. the carboxyl-terminal globular G domain of α1 chain. IgM monoclonal anti-laminin-1 autoantibody, that we recently established, also recognized the G domain. Anti-laminin-1 antibodies from mice immunized with "mouse" laminin-1, caused a higher fetal resorption rate with lower embryonic and placental weights. Thus, anti-laminin-1 antibodies may be important in development of autoimmune-mediated reproductive failures and the assessment of the antibodies may provide a novel non-invasive diagnosis of endometriosis.

    DOI: 10.1080/17402520400001678

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  • Are oxidized LDL/β2-glycoprotein I complexes pathogenic antigens in autoimmune-mediated atherosclerosis? 査読

    Matsuura E, Lopez LR

    Clincal and Developmental Immunology11 ( 2 ) 103 - 111   2004年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/10446670410001722186

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  • Nicked β2-glycoprotein I: a marker of cerebral infarct and a novel role in the negative feedback pathway of extrinsic fibrinolysis. 査読

    Yasuda S, Atsumi T, Ieko M, Matsuura E, Inagaki J, Hisao H, Tanaka H, Yamakado M, Akino M, Saito H, Amasaki Y, Jodo S, Amengual O, Koike T

    Blood103 ( 10 ) 3766 - 3772   2004年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1182/blood-2003-08-2712

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  • Oxidized low-density lipoprotein/β2-glycoprotein I complexes and autoantibodies to oxLig-1/β2-glycoprotein I in patients with systemic lupus erythematosus and antiphospholipid syndrome. 査読

    Lopez D, Garcia-Valladares I, Palafox-Sanchez CA, De La Torre IG, Kobayashi K, Matsuura E, Lopez LR

    Am J Clin Pathol121 ( 3 ) 426 - 436   2004年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1309/2AUE6HD4W6TLEUU5

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  • Immunology of anti-phospholipid antibodies and cofactors 査読

    Tatsuya Atsumi, Eiji Matsuura, Takao Koike

    Systemic Lupus Erythematosus: Fourth Edition   1081 - 1105   2004年

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    記述言語:英語   掲載種別:論文集(書籍)内論文   出版者・発行元:Elsevier Inc.  

    Anti-phospholipid antibodies (aPLs) are present in a wide range of infectious and autoimmune diseases. aPLs, in particular anti-cardiolipin antibodies (aCL) and lupus anticoagulants (LA), are of considerable clinical importance because of the close association with predominant clinical features of venous, arterial thrombosis, and pregnancy morbidity. The term "antiphospholipid syndrome (APS)" has been used to define this set of pathologic features. Numerous studies have elucidated the specificity of anti-phospholipid antibodies (aPLs). It is clear that the nomenclature of aPLs is a misnomer and that these autoantibodies react with phospholipid-binding plasma proteins (cofactors), such as β2-glycoprotein, prothrombin, annexin V, high-molecular-weight kininogen, protein S, and protein C. Many varieties of pathophysiologic mechanisms have been explored in order to understand the wide spectrum of antigenic specificities of aPLs. Numerous observations are reviewed in this discussion concerning putative mechanisms related to anti-β2-GPI antibodies or other aPLs predisposing to thrombosis and to atherosclerosis. © 2004 Elsevier Inc. All rights reserved.

    DOI: 10.1016/B978-012433901-9/50042-9

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  • Anti-laminin-1 autoantibodies in endometriosis 査読

    J Inagaki, M Nakatsuka, M Nomizu, K Aoki, E Matsuura

    PROCEEDINGS OF THE IX INTERNATIONAL CONGRESS OF REPRODUCTIVE IMMUNOLOGY - ISIR   77 - 80   2004年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:MEDIMOND PUBLISHING CO  

    Laminin-1, an extracellular matrix glycoprotein located in the basement membrane (BM), is important in embryogenesis and placentation. We showed that serum IgG anti-laminin-1 autoantibodies (autoAbs) are associated with recurrent first-trimester miscarriages and endometriosis-associated infertility. The Abs were significantly associated with endometriosis, but not with adenomyosis. The Abs recognized the G domain of laminin-a1 chain and several peptides in the domain. The assessment of the Abs may be useful for the diagnosis and medical treatment of endometriosis.

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  • Clinical significance of serum oxidized low-density lipoprotein/β2-glycoprotein I complexes in patients with chronic renal diseases. 査読

    Kasahara J, Kobayashi K, Maeshima Y, Yamasaki Y, Yasuda T, Matsuura E, Makino H

    Nephron Clin Practice98 ( 1 ) C15 - C24   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000079923

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  • 自己免疫と動脈硬化 招待

    松浦栄次, 小林和子, 小池隆夫

    日本アフェレシス学会学会誌23   167 - 175   2004年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Hybridomas expressing gamma delta T-cell receptors respond to cardiolipin and β2-glycoprotein 1 (apolipoprotein H). 査読

    Born WK, Vollmer M, Reardon C, Matsuura E, Voelker DR, Giclas PC, O'Brien R

    Scand J Immunol58 ( 3 ) 374 - 381   2003年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Immunization of naive mice with mouse laminin-1 affected pregnancy outcome in a mouse model 査読

    ST Matalon, M Blank, E Matsuura, J Iganaki, M Nomizu, Y Levi, T Koike, Y Shere, A Ornoy, Y Shoenfeld

    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY50 ( 2 ) 159 - 165   2003年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL MUNKSGAARD  

    PROBLEM: Laminins have important roles during placental and embryonic development. The aim of our study was to determine if active immunization of mice with laminin-1 could elicit an autoimmune response, and induce features of reproductive failure.
    METHOD OF STUDY: BALB/c mice were immunized with mouse laminin-1. Autoantibodies to laminin-1 were measured by enzyme-linked immunosorbent assay. Pregnant mice were killed on day 14 of pregnancy and examined for pregnancy outcome.
    RESULTS: Mice immunized with laminin-1 developed elevated levels of anti-laminin-1 auto-antibodies contrary to the control group. A higher fetal resorption rate was found in the laminin-1 immunized group (23.8%) compared with that of the control group (12.2%), and was even higher in the subgroup of those animals with very high levels of anti-laminin-1 (P < 0.01). Laminin-1 immunized mice also had lower fetal and placental weights.
    CONCLUSIONS: Active immunization with laminin-1 followed by elevated circulating anti-laminin-1 antibodies results in reproductive failure manifested by a higher fetal resorption rate.

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  • IgG autoantibodies against β2-glycoprotein I complexed with a lipid ligand derived from oxidized low-density lipoprotein are associated with arterial thrombosis in antiphospholipid syndrome. 査読

    Lopez D, Kobayashi K, Merrill JT, Matsuura E, Lopez LR

    Clin Develop l Immunol10 ( 2-4 ) 203 - 211   2003年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/10446670310001642113

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  • Circulating oxidized low density lipoprotein forms complexes with β2-glycoprotein I: implication as an atherogenic autoantigen. 査読

    Kobayashi K, Kishi M, Atsumi T, Bertolaccini ML, Makino, H, Sakairi N, Yamamoto I, Yasuda T, Khamashta, MA, Hughes GRV, Koike T, Voelker DR, Matsuura E

    J Lipid Res44 ( 4 ) 716 - 726   2003年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1194/jlr.M200329-JLR200

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  • Anti-idiotypes to oxidized LDL antibodies in intravenous immunoglobulin preparations - Possible immunomodulation of atherosclerosis 査読

    RH Wu, Y Shoenfeld, Y Sherer, M Patnaik, E Matsuura, B Gilburd, T Koike, JB Peter

    AUTOIMMUNITY36 ( 2 ) 91 - 97   2003年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Objective: The aim of this study was to examine whether intravenous immunoglobulin (IVIg) preparations contain anti-oxLDL and anti-anti-oxLDL antibodies.
    Background: Oxidized low-density lipoprotein (oxLDL) is one of the major players in atherogenesis. IVIg can reduce atherosclerosis in experimental animal models.
    Methods: Six commercial IVIg preparations were tested for the presence of anti-oxLDL antibodies by EIA. Inhibition studies were performed with the different IVIg preparations and IgGs purified from a pool of sera from patients with high anti-oxLDL antibody levels. Absorption assays were carried out to evaluate the presence of anti-idiotypes against anti-oxLDL antibodies in IVIg preparations.
    Results: IVIg preparations tested had various degrees of reactivity towards oxLDL. Absorption experiments suggested that the reactivity was specific because it could be effectively absorbed by oxLDL and not by an irrelevant antigen PPD. The reactivity was smaller than that observed with the IgG from the pool with high anti-oxLDL antibody levels. Inhibition studies with IVIg demonstrated 20-45% inhibition of anti-oxLDL binding to oxLDL, compared to 76% inhibition by the pool with high anti-oxLDL levels. To investigate the presence of anti-idiotypes against anti-oxLDL antibodies within IVIg, F(ab')(2) fragments of IVIg IgG were used to absorb IgG F(ab')(2) fragments from the pool of sera with high anti-oxLDL levels. The decreased binding to oxLDL of the absorbed supernatants shows that IgG F(ab')(2) fragments of the IVIg preparations had high inhibitory capacities ranging from 65 to 90%.
    Conclusions: IVIg preparations contain both anti-oxLDL and anti-anti-oxLDL activity. This finding may explain the immunomodulating effect of IVIg in atherosclerosis.

    DOI: 10.1080/0891693031000080228

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  • An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients 査読

    J Inagaki, M Sugiura-Ogasawara, M Nomizu, M Nakatsuka, K Ikuta, N Suzuki, K Kaihara, K Kobayashi, T Yasuda, Y Shoenfeld, K Aoki, E Matsuura

    HUMAN REPRODUCTION18 ( 3 ) 544 - 549   2003年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OXFORD UNIV PRESS  

    BACKGROUND: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. METHODS: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. RESULTS: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-alpha1 chain G domain. mRNA encoding laminin-alpha1, -beta1, and -gamma1 chains was expressed in 90% of endometriotic lesions. CONCLUSIONS: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.

    DOI: 10.1093/humrep/deg148

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  • Multiple autoantibodies associated with autoimmune reproductive failure 査読

    Y Sherer, S Tartakover-Matalon, M Blank, E Matsuura, Y Shoenfeld

    JOURNAL OF ASSISTED REPRODUCTION AND GENETICS20 ( 2 ) 53 - 57   2003年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KLUWER ACADEMIC/PLENUM PUBL  

    Purpose: Autoimmune factors are involved in some of the cases of reproductive failure. The aim of this paper is to discuss the association between autoantibodies and reproductive failure.
    Methods: Literature review of autoantibodies associated with reproductive failure.
    Results: Several autoantibodies were found in association with such clinical manifestations, mainly in patients having systemic lupus erythematosus or the antiphospholipid syndrome. These autoantibodies include "classical" antiphospholipid antibodies such as anticardiolipin, anti-beta2-glycoprotein-I, antiphosphatidylserine, and antiphosphatidylethanolamine. There are also some "nonclassical" antiphospholipid antibodies directed to prothrombin, thromboplastin, or mitochondrial antibodies of M5 type, which were also found in patients with reproductive failure. Moreover, animal models as well as some human studies support a role for other autoantibodies in these clinical manifestations including antithyroglobulin, antilaminin-1, anti-corpus luteum, antiprolactin, anti-poly(ADP-ribose), and lymphocytotoxic antibodies.
    Conclusions: Even though there is not enough data currently to support a firm association between some of these autoantibodies and reproductive failure, future studies are likely to help us determine and expand the number of autoantibodies screened in these patients.

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  • Atherogenic autoantigen: oxidized LDL complexes with β2-glycoprotein I. 査読

    Matsuura E, Kobayashi K, Koike T, Shoenfeld Y, Khamashta MA, Hughes GRV

    Immunobiol207 ( 1 ) 17 - 22   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 子宮内膜症と抗ラミニン-1抗体 招待 査読

    稲垣純子, 青木耕治, 松浦栄次

    臨床免疫39   575 - 581   2003年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Oxidized low-density lipoprotein as a risk factor of thrombosis in antiphospholipid syndrome 査読

    E Matsuura, K Kobayashi, T Koike, Y Shoenfeld, MA Khamashta, GRV Hughes

    LUPUS12 ( 7 ) 550 - 554   2003年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ARNOLD, HODDER HEADLINE PLC  

    beta2-Glycoprotein I (beta2-GPI) is a major antigen for anticardiolipin antibodies (aCL, Abs) present in patients with antiphospholipid syndrome (APS). We recently reported that oxidized LDL (oxLDL) is subsequently targeted by beta2-GPI and anti-beta2-GPI auto-Abs and that -carboxyl variants of 7-ketocholesteryl esters, such as 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and 7-ketocholesteryl-12-carboxy (keto) octadodecanoate (oxLig-2), are ligands for beta2-GPI (J Lipid Res 2001; 42: 697; J Lipid Res 2002; 43: 1486). These beta2-GPI ligands provide an electrostatic interaction between oxLDL and beta2-GPI followed by forming stable complexes (such as Schiff base adducts). The -carboxyl function in these ligands is responsible for beta2-GPI binding to oxLDL and the oxLDL-beta2-GPI complexes are anti-beta2-GPI auto-Ab-dependently taken up by macrophages (i.e., by phagocytosis). Our recent observations are consistent with the evidence that beta2-GPI co-localizes with lymphocytes and mononuclear cells in human athero-plaques. Thus, autoimmune thrombogenesis (atherogenesis) is linked to interaction of anti-beta2-GPI Abs with the beta2-GPI-oxLDL complexes. We propose an alternative idea, that an immune response against the beta2-GPI-oxLDL complexes may be involved in mechanisms in the development of atherosclerosis, which has been explained by the theory of 'the response to injury'.

    DOI: 10.1191/0961203303lu400oa

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  • Autoantibody-mediated atherosclerosis 招待 査読

    Eiji Matsuura, Kazuko Kobayashi, Takao Koike, Yehuda Shoenfeld

    Autoimmunity Reviews1 ( 6 ) 348 - 353   2002年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    β2-Glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (aPL) present in patients with antiphospholipid syndrome (APS). Oxidized low-density lipoprotein (oxLDL) is subsequently targeted by β2-GPI and anti-β2-GPI autoantibodies. Ligands specific for β2-GPI derived from oxLDL have been characterized as oxidized forms of cholesteryl linoleate, such as 7-ketocholesterol-9-carboxynonanoate, i.e. 9-oxo-9-(7-ketocholest-5-en-3β- yloxy) nonanoic acid, (namely oxLig-1). The in vitro phenomenon that it is significantly increased in binding of oxLig-1 containing liposomes to macrophages via an interaction with β2-GPI and an anti-β2-GPI autoantibody (via the Fcγ receptor) may propose a novel mechanism on 'autoantibody-mediated athrosclerosis'. Furthermore, autoantibodies against a complex of β2-GPI and oxLig-1 are detected in sera of APS patients and appearance of the antibodies is associated with episodes of thrombosis, especially, arterial thrombosis. Thus, autoimmune atherogenesis linked to β2-GPI interaction with oxLDL and autoantibodies may be present in APS. © 2002 Elsevier Science B.V. All rights reserved.

    DOI: 10.1016/S1568-9972(02)00084-8

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  • Omega-carboxyl variants of 7-ketocholesteryl esters are ligands for β2-glycoprotein I and mediate antibody-dependent uptake of oxidized LDL by macrophages.

    Liu Q, Kobayashi K, Furukawa J, Inagaki J, Sakairi N, Iwado A, Yasuda T, Koike T, Voelker DR, Matsuura E

    J Lipid Res43 ( 9 ) 1486 - 1495   2002年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1194/jlr.M20063-JLR200

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  • Anti-β2-glycoprotein I antibodies in children with atopic dermatitis. 査読

    Ambrozic A, Avicin T, Ichikawa K, Kveder T, Matsuura E, Hojnik M, Atsumi T, Rozman B, Koike T

    Int Immunol14 ( 7 ) 823 - 830   2002年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • The orientation of β2GPI on the plate is important for the binding of anti-β2GPI autoantibodies by ELISA. 査読

    Iverson GM, Matsuura E, Victori EJ, Cockerill KA, Linnik MD

    J Autoimmun18 ( 4 ) 289 - 297   2002年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1006/jaut.2002.0590

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  • Anti-β2-glycoprotein I autoantibodies and atherosclerosis. 査読

    Matsuura E, Kobayashi K, Kasahara J, Yasuda T, Makino H, Koike T, Shoenfeld Y

    Int Rev Immunol21   51 - 66   2002年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 抗リン脂質抗体症候群 招待

    松浦栄次

    岡山医学会雑誌114   19 - 26   2002年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Analysis of epitopes of mouse monoclonal antibodies against human alpha-fetoprotein 査読

    Y Kang, E Matsuura, T Sakamoto, M Sakai, S Nishi

    TUMOR BIOLOGY22 ( 4 ) 254 - 261   2001年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Thirty-six monoclonal antibodies (MAbs) against human alpha-fetoprotein (AFP) were analyzed for the location of their epitopes by reacting them with a set of yeast recombinant AFP proteins using ELISA. Recombinant AFP proteins containing either one, two or all three domains, i.e. domain I, domain III, domain I-II, domain II-III and domain I-II-III, were produced and secreted into the culture medium of yeast cells harboring the expression plasmids. Epitopes of 13 MAbs were localized on domain I and 17 others were on domain III. However, the exact location of the epitopes of the remaining 6 MAbs could not be defined. The epitope of an antibody, namely AFY6, which was located in domain I, was successfully mapped on an octapeptide, C(175)KAENAVE(182), using synthesized overlapping octapeptides. Copyright (C) 2001 S. Karger AG, Basel.

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  • A specific ligand for beta(2)-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages 査読

    K Kobayashi, E Matsuura, Q Liu, J Furukawa, K Kaihara, J Inagaki, T Atsumi, N Sakairi, T Yasuda, DR Voelker, T Koike

    JOURNAL OF LIPID RESEARCH42 ( 5 ) 697 - 709   2001年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPID RESEARCH INC  

    beta (2)-Glycoprotein I (beta (2)-GPI) is a major antigen for antiphospholipid antibodies (Abs) present in patients with the antiphospholipid syndrome (APS), We previously reported that beta (2)-GPI specifically binds to oxidized low density lipoprotein (oxLDL), but not to native low density lipoprotein (LDL), In the present study, a ligand specific for beta (2)- GPI, oxLig-1, was purified from the extracted lipids of oxLDL, The structure of oxLig-1 was sho cvn to be identical to that of synthesized 7-keto cholesteryl-9-carboxynonanoate by mass spectroscopy and nuclear magnetic resonance analyses. Both purified and synthesized oxLig-1 were recognized by beta (2)-GPI and subsequently by anti-BP-GPI auto-Abs, either in enzyme-linked immunosorbent assay (ELISA) or in ligand blot analysis. Binding of liposomes containing oxLig-1 (oxLig-1-liposomes) to mouse macrophages, J774A.1 cells, was relatively low, as compared with that of phosphatidylserine (PS)-liposomes. In contrast, binding of oxLig-1-liposomes was enhanced more than 10-fold in the presence of both beta2-GPI and an anti-beta (2)-GPI auto-Ab (WB-CAL-1), derived from (NZW x BXSB) F1 mouse, an animal APS model, Anti-PP-GPI auto-Abs derived from APS patients with episodes of arterial thrombosis were detected in ELISA, using a solid phase oxLig-1 complexed with beta (2)-GPI.j/r We suggest that autoimmune atherogenesis linked to PP-GPI interaction with oxLDL and Abs may be present in APS.-Kobayashi Ii, E. Matsuura, Q. Liu, J. Furukawa, It. Kaihara, J. Inagaki, T. Atsumi, N. Sakairi, T. Yasuda, D. R. Voelker, and T. Koike. A specific ligand for beta (2)-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages.

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  • IgG anti-laminin-1 autoantibody and recurrent miscarriages 査読

    J Inagaki, E Matsuura, M Nomizu, M Sugiura-Ogasawara, K Katano, K Kaihara, K Kobayashi, T Yasuda, K Aoki

    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY45 ( 4 ) 232 - 238   2001年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MUNKSGAARD INT PUBL LTD  

    PROBLEM: The present study assesses the clinical significance of anti-lamillin-1 auto-antibodies (auto-Abs) in recurrent miscarriages.
    METHOD OF STUDY: A total of 207 recurrent aborters with a history of two or more consecutive first-trimester miscarriages were tested for the presence of anti-laminin-1 Abs, beta (2)-glycoprotein I-dependent anticardiolipin Abs, lupus anticoagulants, anti-DNA Abs, and anti-nuclear Abs, before they had conceived again. Recurrent aborters then were followed up during subsequent pregnancies and their outcomes were evaluated relative to their blood test results prior to pregnancy.
    RESULTS: Fifty-five (31.1%) women out of 177 recurrent aborters were positive for IgG anti-laminin-1 auto-Abs. The levels of IgG anti-laminin-1 auto-Abs in recurrent aborters were significantly higher than those in healthy pregnant women and in healthy non-pregnant women (P = 0.0043 and 0.0073, respectively). The live birth rate of subsequent pregnancies in IgG anti-laminin-1 auto-Abs-positive recurrent aborters was significantly lower than the IgG anti-laminin-1 auto-Abs-negative recurrent aborters (P = 0.0320). There were no specifically significant relationships observed between IgG anti-laminin-1 auto-Abs and other tested auto-Abs.
    CONCLUSION: IgG anti-laminin-1 auto-Abs are associated with recurrent miscarriages and the subsequent pregnancy outcome of recurrent aborters.

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  • 抗リン脂質抗体と動脈硬化 招待

    松浦栄次

    臨床免疫36   564 - 573   2001年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • IgG抗ラミニン-1自己抗体:反復流産および子宮内膜症の危険因子 招待

    稲垣純子

    第31回日本免疫学会総会・学術集会   2001年

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    記述言語:日本語   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • beta2-グリコプロテインIに特異的な酸化脂質リガンドと自己抗体の動脈硬化進展への関与 招待

    松浦栄次

    第31回日本免疫学会総会・学術集会   2001年

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    記述言語:日本語   掲載種別:研究論文(研究会,シンポジウム資料等)  

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  • 抗リン脂質抗体とマクロファージによる酸化LDLの取り込み

    松浦栄次

    臨床免疫36,1,116-122   2001年

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  • β2-Glycoprotein I deficiency: prevalence, genetic background and effects on plasma lipoprotein metabolism and hemostasis. 査読

    Yasuda S, Tsutsumi A, Chiba H, Yanai H, Miyoshi Y, Takeuchi R, Hiorta T, Atsumi T, Ichikawa K, Matsuura E, Koike T

    Atherosclerosis152 ( 2 ) 337 - 346   2000年10月

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  • β2-glycoprotein I-anti-β2-glycoprotein I interaction. 招待

    Koike T, Ichikawa K, Atsumi T, Kasahara H, Matsuura E

    J Autoimmun15 ( 2 ) 97 - 100   2000年9月

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  • Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant 査読

    T Atsumi, M Ieko, ML Bertolaccini, K Ichikawa, A Tsutsumi, E Matsuura, T Koike

    ARTHRITIS AND RHEUMATISM43 ( 9 ) 1982 - 1993   2000年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    Objective. To clarify the association of autoantibodies against prothrombin with the clinical manifestations of the antiphospholipid syndrome (APS) and with the presence of lupus anticoagulant (LAC).
    Methods. We examined 265 patients who visited our autoimmune disease clinic. IgG and IgM antiprothrombin antibodies were tested by enzyme-linked immunosorbent assay (ELISA) as either antiphosphatidylserine-prothrombin complex (aPS/PT) antibodies or as antibodies against prothrombin coated on irradiated ELISA plates (as antigen) (aPT). IgG, IgM, and IgA anticardiolipin (aCL) antibodies and their beta(2)-glycoprotein I (beta(2)GPI) dependency were also evaluated by ELISA. LAC was tested by 3 different methods.
    Results. The presence of aPS/PT, but not of aPT, significantly correlated with the clinical manifestations of APS (odds ratio [OR] 4.39, 95% confidence interval [95% CI] 2.06-9.38), and aPS/PT antibodies were as specific as beta(2)GPI-dependent aCL for APS (93.1% for both). IgG aPS/PT strongly correlated with the presence of LAC as detected using the dilute Russell viper venom time test (OR 38.2, 95% CI 13.4-109.1).
    Conclusion. Antiprothrombin antibodies are heterogeneous and their clinical relevance depends on the method of detection applied. Positive results on the aPS/PT test can serve as a marker of thrombotic events in patients with autoimmune diseases.

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  • Proteolytic cleavage of β<sub>2</sub>-glycoprotein I : reduction of antigenicity and the structural relationship 査読

    Matsuura E, Inagaki J, Kasahara H, Yamamoto D, Atsumi T, Kobayashi K, Kaihara K, Zhao D, Ichikawa K, Tsutsumi A, Yasuda T, Triplett DA, Koike T

    Int Immunol12 ( 8 ) 1183 - 1192   2000年8月

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  • Proteolytic cleavage of β2-glycoprotein I: reduction of antigenicity and the structural relationship. 査読

    Matsuura E, Inagaki J, Kasahara H, Yamamoto D, Atsumi T, Kobayashi K, Kaihara K, Zhao D, Ichikawa K, Tsutsumi A, Yasuda T, Triplett DA, Koike T

    Int Immunol12 ( 8 ) 1183 - 1192   2000年8月

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  • Heterogeneous behavior of anti-β2-glycoprotein I antibodies on various commercially available enzyme immunoassay plates coated with β2-glycoprotein I.

    Tsutsumi A, Ichikawa K, Matsuura E, Sawada K, Koike T

    J Rheumatol27 ( 2 ) 391 - 396   2000年2月

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  • Heterogenous behavior of anti-β<sub>2</sub>-glycoprotein I antibodies on various commercial available enzyme immunoassay plates coated with β<sub>2</sub>-glycoprotein I 査読

    Tsutsumi A, Ichikawa K, Matsuura E, Sawada K, Koike T

    J Rheumatol27 ( 2 ) 391 - 396   2000年2月

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  • Accelerated atheroma and anti-β2-glycoprotein I antibodies. 招待

    Matsuura E, Koike T

    Lupus9 ( 3 ) 210 - 216   2000年

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  • 抗リン脂質抗体の測定原理と多様性 招待

    松浦栄次

    臨床病理48   317 - 322   2000年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 抗リン脂質抗体の反応エピトープとその機能 招待

    松浦栄次, 小池隆夫

    リウマチ科23   422 - 428   2000年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 全身性エリテマトーデスの病態形成に関与する分子群・抗リン脂質抗体 招待

    保田晋助, 渥美達也, 笠原英樹, 松浦栄次, 市川健司, 小池隆夫

    臨床免疫34   470 - 474   2000年

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  • 抗リン脂質抗体・ループスアンチコアグラント 招待

    松浦栄次

    血栓と循環8   134 - 139   2000年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 抗リン脂質抗体と動脈硬化 招待

    松浦栄次, 小林和子, 笠原順子, 貝原恵子, 小池隆夫

    リウマチ科24   378 - 384   2000年

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  • A chimeric antibody with the human γ'' constant region as a putative standard for assays to detect IgG β<sub>2</sub>-glycoprotein I (β<sub>2</sub>-GPI) dependent anticardiolipin and anti-β<sub>2</sub>GPI antibodies 査読

    Ichikawa K, Tsutsumi A, Atsumi T, Matsuura E, Kobayashi S, Hughes GRV, Khamashta MA, Koike T

    Arthritis Rheum42 ( 11 ) 2461 - 2470   1999年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Modulation of T cell function by α-fetoprotein: an in vivo study on porcine thyroid peroxidase-induced experimental autoimmune thyroiditis in transgenic mice producing human α-fetoprotein. 査読

    Matsuura E, Kang Y, Kitakawa H, Ogata A, Kotani T, Ohtaki S, Nishi S

    Tumor Biol20 ( 3 ) 162 - 171   1999年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Antiphospholipid syndrome 招待

    K Ichikawa, A Tsutsumi, E Matsuura, T Koike

    INTERNAL MEDICINE38 ( 2 ) 170 - 173   1999年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

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  • β2-Glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies.

    Ieko M, Ichikawa K, Triplett DA, Matsuura E, Atsumi T, Sawada K, Koike T

    Arthritis Rheum42 ( 1 ) 167 - 174   1999年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • β<sub>2</sub>-Glycoprotein I is necessary to inhibit protein C activity by monoclonal anticardiolipin antibodies 査読

    Ieko M, Ichikawa K, Triplett DA, Matsuura E, Atsumi T, Sawada K, Koike T

    Arthritis Rheum42 ( 1 ) 167 - 174   1999年1月

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  • A 50-kDa variant form of human surfactant protein D 査読

    RJ Mason, LD Nielsen, Y Kuroki, E Matsuura, JH Freed, JM Shannon

    EUROPEAN RESPIRATORY JOURNAL12 ( 5 ) 1147 - 1155   1998年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MUNKSGAARD INT PUBL LTD  

    The dominant form of human surfactant protein D (SP-D) is a multimeric collagenous glycoprotein composed of monomeric subunits that have a molecular mass of 43 kDa under reducing conditions, However, in evaluating monoclonal antibodies to human SP-D, an additional monomeric subunit was identified with a reduced molecular mass of 50 kDa.
    This 50-kDa variant was detected in approximately half of the samples evaluated and was found in lavage fluid from normal subjects, patients with alveolar proteinosis or idiopathic pulmonary fibrosis and in amniotic fluid. This 50-kDa variant had the same amino-terminal sequence, amino acid composition and apparent size of the carboxy-terminal collagenase-resistant fragment (20 kDa) as the 43-kDa subunit. The major difference was in the amino-terminal portion of the molecule and was due to altered glycosylation, as determined by carbohydrate staining, chemical deglycosylation, treatment with N-glycanase and neuraminidase and reduced signals for threonine at positions 5, 9 and 10 during amino-terminal sequencing.
    After gel filtration chromatography, the 50-kDa form was not present in the high molecular weight fraction, which is commonly used in purification of SP-P), but was found only in the smaller molecular weight fraction of monomers and trimers of SP-D.
    In conclusion, the 50 kDa-form of surfactant protein D is produced by post-translational glycosylation and does not form higher ordered oligomers, but its precise physiological function remains to be determined.

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  • Use of various methods for anticardiolipin detection in the updated American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus: comment on the letter by Hochberg 査読

    A Tsutsumi, K Ichikawa, T Atsumi, E Matsuura, T Koike, SA Krilis

    ARTHRITIS AND RHEUMATISM41 ( 7 ) 1326 - 1327   1998年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Target recognition of β<sub>2</sub>-glycoprotein I-dependent anticardiolipin antibodies : evidence for involvement of the fourth domain of β2-GPI in antibody binding. 査読

    George J, Hojnik M, Gilburd B, Blank M, Langevitz P, Matsuura E, Koike T, Shoenfeld Y

    J Immunol160 ( 8 ) 3917 - 3923   1998年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • IgA class anti-β<sub>2</sub>-glycoprotein I in patients with systemic lupus erythematosus. 査読

    Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Koike T

    J Rheumatol25 ( 1 ) 74 - 78   1998年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Antiphospholipid antibodies and atherosclerosis 招待

    E Matsuura, K Kobayashi, T Yasuda, T Koike

    LUPUS7   S135 - S139   1998年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:STOCKTON PRESS  

    B-2-Glycoprolein I (beta(2)-GPI) is a major antigen for anticardiolipin antibodies (aCL) induced in patients with antiphospholipid syndrome and their antigenic epitopes are cryptic. The epitopes appear on the surface of beta(2)-GPI molecule only when beta(2)-GPI interacts with lipid membranes containing negatively charged phospholipids or polyoxygenated polystyrene surface. Our data also indicated that CuSO4-oxidized low density lipoproteins (oxLDL) are subsequently targeted by beta(2)-GPI and aCL; however, malonedialdehyde (MDA)-modified LDL were recognized neither by beta(2)-GPI nor aCL. beta(2)-GPI binding to LDL was rapidly increased by incubation with CuSO4. Oxidation of lipoproteins was accompanied with the increment of thiobarbituric acid-reactive substances (TBARS) and denature of apolipoprotein. Ligands on LDL for beta(2)-GPI seemed to be intermediate oxidative derivatives which were extractable into the chloroform phase by Bligh and Dyer's extraction, but not MDA. Further, immune responses against beta(2)-GPI, as an anti-atherogenic protein, were demonstrated to induce atherogenic effect in in vitro oxLDL uptake by macrophages.

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  • Anti-β2-glycoprotein I antibodies. 招待

    Tsutsumi A, Ichikawa K, Matsuura E, Koike T

    Lupus7   S98 - S102   1998年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Epitopes on β2-GPI recognized by anticardiolipin antibodies.

    Koike T, Ichikawa K, Kasahara H, Atsumi A, Matsuura E

    Lupus7   S14 - S17   1998年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 抗リン脂質抗体症候群における新展開 招待

    松浦栄次, 小池隆夫

    炎症と免疫6   76 - 82   1998年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 抗カルジオリピン抗体と血栓形成 招待

    松浦栄次, 北川浩彦, 保田立二, 小池隆夫

    臨床免疫30   239 - 245   1998年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 自己免疫疾患の病態と治療.1.自己免疫疾患の病態−最近の知見から−.3)抗リン脂質抗体症候群 招待

    市川健司, 堤 明人, 渥美達也, 松浦栄次, 小池隆夫

    日本内科学会雑誌87   1729 - 1734   1998年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Antibodies to β2-glycoprotein I in patents with systemic lupus erythematosus: comment on the articles by Tsutsumi et al and Roubey et al. Reply 査読

    Tsutsumi A, Matsuura E, Ichikawa K, Koike T

    Arthritis Rheum40 ( 7 ) 1366 - 1367   1997年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Immunogenic characterization and functional properties of murine antibodies raised against deleted mutants of human β<sub>2</sub>-glycoprotein I. 査読

    George J, Blank M, Gilburd B, Hojnik M, Shenkman B, Tamarin I, Varon D, Matsuura E, Koike T, Shoenfeld Y

    Int Immunol9 ( 6 ) 913 - 921   1997年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Oxidized low-density lipoprotein (Ox-LDL) but not LDL aggravates the manifestations of experimental antiphospholipid syndrome (APS) 査読

    J George, M Blank, M Hojnik, E BarMeir, T Koike, E Matsuura, M Lorber, M Aviram, Y Shoenfeld

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY108 ( 2 ) 227 - 233   1997年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL SCIENCE LTD  

    Ox-LDL is thought to play a major role in atherogenesis. The mechanisms mediating the deleterious influences of Ox-LDL include foam cell formation and cell cytotoxicity. The production of anti-Ox-LDL antibodies results in the formation of immune complexes which are taken up at enhanced rate by macrophages, leading to foam cell formation. APS is characterized by repeated venous and arterial thromboembolic phenomena, recurrent fetal loss and thrombocytopenia, associated with the presence of antibodies to negatively charged phospholipids (aPL) (i.e. cardiolipin, phosphatidylserine). Phospholipids bear structural resemblance to LDL, and several studies have indeed proved that aPL display cross-reactivity with anti-Ox-LDL antibodies. In this study we assessed the capacity of oxidized and native forms of LDL to aggravate the clinical picture of experimentally induced APS in naive mice. Mice were actively immunized intradermally with anticardiolipin antibodies and developed a clinical picture resembling APS in humans. Subsequently, the mice were infused with either Ox-LDL, native LDL or PBS, and similar regimens were applied to controls. APS mice infused with Ox-LDL were found to exhibit a significantly more severe form of the disease in comparison with native LDL- and PBS-infused mice, expressed by lower platelet counts (261 000/mm(3), 535 000/mm(3) and 455 000/mm(3), respectively), longer activated partial thromboplastin time (aPTT) (99 +/- 12 s, 63 +/- s s and 74 +/- 8 s respectively) and higher fetal resorption rates (72.7%, 34.4% and 32.6%, respectively). The results of this study show that Ox-LDL, compared with native LDL, aggravates the clinical manifestations of experimental APS and suggest that cross-reactivity of Ox-LDL with phospholipids may provide a pathogenic explanation for this effect.

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  • Anti-β<sub>2</sub>-glycoprotein I(β<sub>2</sub>-GPI)monoclonal antibodies with lupus anticoagulant-like activity enhance the β<sub>2</sub>-GPI binding to phospholipid. 査読

    Takeya H, Mori T, Gabazza EC, Kuroda K, Deguchi H, Matsuura E, Ichikawa K, Koike T, Suzuki K

    J Clin Invest99 ( 9 ) 2260 - 2268   1997年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • β2-Glycoprotein I and antiphospholipid syndrome. 招待

    Koike T, Matsuura E

    Israel J Med Sci (Continued by Isr Med Assoc J)33 ( 4 ) 225 - 238   1997年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Involvement of β<sub>2</sub>-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages. 査読

    Hasunuma Y, Matsuura E, Makita Z, Katahira T, Nishi S, Koike T

    Clin Exp Immunol107 ( 3 ) 569 - 573   1997年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • DNA-alginate complex recognized by autoantibodies against DNA 査読

    H Kitamura, E Matsuura, A Nagata, N Sakairi, S Tokura, N Nishi

    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES20 ( 1 ) 75 - 77   1997年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Double-stranded DNA was effectively complexed with alginic acid and immobilized on a surface of polystyrene microtiter plate. Dose-dependent binding of anti-DNA autoantibodies was finely observed to the solid phase DNA-alginate complex in enzyme-linked immunosorbent assay (ELISA). In contrast, non-specific binding of antibodies to alginate was scarcely detected ratheer than to poly-L-lysine. These results show an availability of the solid phase DNA-alginate complex as an antigen in ELISA for detection of anti-DNA antibodies. (C) 1997 Elsevier Science B.V.

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  • Structure and function of the recombinant fifth domain of human β<sub>2</sub>-glycoprotein I : effect of specific cleavage between Lys77 and Thr78. 査読

    Hagihara Y, Enjyoji K, Omasa T, Katakura Y, Suga K, Igarashi M, Matsuura E, Kato H, Goto Y

    J Biochem121 ( 1 ) 128 - 137   1997年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • β2-グリコプロテインIと抗リン脂質抗体 招待

    松浦栄次, 北川浩彦, 小池隆夫

    内科80   34 - 38   1997年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Conformational change of DNA on the formation of DNA-anti-DNA antibody immune complex. 査読

    Kitamura H, Shindo K, Sasabe M, Matsuura E, Sakairi N, Nishi N

    Nucleic Acids Symp Ser37   145 - 146   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 抗カルジオリピン抗体 招待

    松浦栄次, 北川浩彦, 小池隆夫

    日本アフェレシス学会学会誌16   353 - 360   1997年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Anti-β2-glycoprotein I antibodies and lupus anticoagulant in patients with recurrent pregnancy loss: prevalence and clinical significance. 査読

    Ogasawara M, Aoki K, Matsuura E, Sasa H, Yagami Y

    Lupus5 ( 6 ) 587 - 592   1996年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Anti-β2-glycoprotein I antibody: specificity and clinical significance. 招待

    Koike T, Matsuura E

    Lupus5 ( 5 ) 378 - 380   1996年10月

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  • Antibodies to β2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus. 査読

    Tsutsumi A, Matsuura E, Ichikawa K, Fujisaku A, Mukai M, Kobayashi S, Koike T

    Arthritis Rheum39 ( 9 ) 1466 - 1474   1996年9月

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  • Anticardiolipin antibodies and β2-glycoprotein I. 査読

    Koike T, Matsuura E

    Lupus5 ( 2 ) 156 - 157   1996年4月

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  • Human β<sub>2</sub>-glycoprotein I as an anticardiolipin cofactor determined using deleted mutants expressed by a baculovirus system. 査読

    Igarashi M, Matsuura E, Igarashi Y, Nagae H, Ichikawa K, Triplett DA, Koike T

    Blood87 ( 8 ) 3262 - 3270   1996年4月

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  • β2-Glycoprotein I-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in healthy pregnant women. 査読

    Katano K, Aoki K, Sasa H, Ogasawara M, Matsuura E, Yagami Y

    Human Reprod11 ( 3 ) 509 - 512   1996年3月

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  • Phospholipid-dependent anti-β2-glycoprotein I (β2-GPI) antibodies and antiphospholipid syndrome. 査読

    Kaburaki J, Kuwana M, Yamamoto M, Kawai S, Matsuura E, Ikeda Y

    Internal Med35 ( 2 ) 105 - 110   1996年2月

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  • Participation of αIIbβ3 in platelet microparticle generation by collagen plus thrombin 査読

    Nomura S, Komiyama Y, Matsuura E, Xie GL, Katsura K, Miyake T, Miyazaki Y, Kagawa H, Koike T

    Haemostasis (Pathophysiology of Haemostasis and Thrombosis)26 ( 1 ) 31 - 37   1996年1月

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  • 抗リン脂質抗体の多様性 招待

    松浦栄次, 西 信三, 小池隆夫

    臨床免疫28   1566 - 1575   1996年

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  • 抗リン脂質抗体のエピトープマッピング 招待

    松浦栄次, 小池隆夫

    医学の歩み176   325 - 329   1996年

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  • 抗カルジオリピン抗体の測定法 招待

    松浦栄次, 小池隆夫

    臨床検査40   141 - 145   1996年

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  • PULMONARY SURFACTANT PROTEIN-D IN SERA AND BRONCHOALVEOLAR LAVAGE FLUIDS 査読

    Y HONDA, Y KUROKI, E MATSUURA, H NAGAE, H TAKAHASHI, T AKINO, S ABE

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE152 ( 6 ) 1860 - 1866   1995年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER LUNG ASSOC  

    Pulmonary surfactant protein D (SP-D) is a hydrophilic glycoprotein with a reduced molecular mass of 43 kDa and a member of the C-type lectin superfamily, along with mannose-binding proteins and surfactant protein A (SP-A). We have recently prepared monoclonal antibodies against human SP-D and developed an enzyme-linked immunosorbent assay (ELISA). In this study, the levels of SP-D in sera and bronchoalveolar lavage (BAL) fluids of patients with lung diseases were determined by ELISA, using human recombinant SP-D as a standard. We demonstrated that the concentrations of SP-D in sera are prominently increased in patients with idiopathic pulmonary fibrosis (IPF), interstitial pneumonia with collagen disease (IPCD), and pulmonary alveolar proteinosis (PAP). Patients with IPF, IPCD, and PAP exhibited levels of serum SP-D 5.1-fold, 7.2-fold, and 7.0-fold, respectively, of those in healthy volunteers; 91.5% of the patients with IPF, 81.3% with IPCD, and 100% with PAP exhibited serum SP-D levels that exceeded the cut-off value (mean + 2 SD of control value). Serum SP-D levels appeared to reflect the disease activity of IPF and IPCD and the disease severity of PAP. High levels of SP-D in BAL fluids were shown in patients with PAP, but not with IPF and IPCD. We conclude that measurement of SP-D in sera can provide an easily identifiable and useful clinical marker for the diagnosis of IPF, IPCD, and PAP, and can predict the disease activity of IPF and IPCD and the disease severity of PAP.

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  • Clinical significance of phospholipid-dependent anti-β2-glycoprotein I (β2-GPI) antibodies in systemic lupus erythematosus. 査読

    Kaburaki J, Kuwana M, Yamamoto M, Kawai S, Matsuura E, Ikeda Y

    Lupus4 ( 6 ) 472 - 476   1995年12月

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  • AUTOIMMUNE-PRONE (NZWXBXSB)F-1 (W/BF1) MICE ESCAPE SEVERE THROMBOCYTOPENIA AFTER TREATMENT WITH DEOXYSPERGUALIN, AN IMMUNOSUPPRESSANT 査読

    K NEMOTO, T MAE, K SAIGA, E MATSUURA, T KOIKE

    BRITISH JOURNAL OF HAEMATOLOGY91 ( 3 ) 691 - 696   1995年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BLACKWELL SCIENCE LTD  

    Male (NZW x BXSB)F-1 mice spontaneously develop a disease which closely resembles human systemic autoimmune disease, involving idiopathic thrombocytopenic purpura and glomerulonephritis. We investigated whether autoimmune thrombocytopenia in the mice responded to deoxyspergualin, as immunosuppressant. Deoxyspergualin completely prevented the development of thrombocytopenia and suppressed the increase in circulating autoantibodies against platelets. This agent also ameliorated lupus nephritis. These findings suggest that deoxyspergualin may be effective in the prevention of idiopathic thrombocytopenic purpura.

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  • Anticardiolipin antibodies in patients with pregnancy loss induce factor Xa production in the presence of β2-glycoprotein I. 査読

    Ogasawara M, Aoki K, Matsuura E, Kunimatsu M, Ohkubo I, Galli M, Sasaki M, Yagami Y

    Am J Reprod Immunol34 ( 5 ) 269 - 273   1995年11月

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  • Systemic lupus erythematosus and anticardiolpin antibodies in Klinfelter’s syndrome. 査読

    Miyagawa S, Matsuura E, Kitamura W, Ohno H, Kichikawa K, Uchida H, Shirai T, Okamoto S

    Lupus4 ( 3 ) 236 - 238   1995年6月

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  • ANTIGENIC SPECIFICITY OF THE ANTICARDIOLIPIN ANTIBODIES 査読

    T KOIKE, A TSUTSUMI, K ICHIKAWA, E MATSUURA

    BLOOD85 ( 8 ) 2277 - 2278   1995年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:W B SAUNDERS CO  

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  • Clinical significance of β2-glycoprotein I-dependent anticardiolipin antibodies in reproductive autoimmune failure syndrome : correlation with conuentional antiphospholipid antibody detection system. 査読

    Aoki K, Dudkiewicz AB, Matsuura E, Novotny M, Kaberlein G, Gleicher N

    Am J Obst Gynecol172 ( 3 ) 926 - 931   1995年3月

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  • Disease distribution of β2-glycoprotein I-dependent anticardiolipin antibodies in rheumatic diseases. 招待

    Kaburaki J, Kuwana M, Yamamoto M, Kawai S, Matsuura E, Ikeda Y

    Lupus4   S27 - S31   1995年2月

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  • Molecular studies on phospholipid-binding sites and cryptic epitopes appearing on β<sub>2</sub>-glycoprotein I structure recognized by anticardiolipin antibodies. 招待 査読

    Matsuura E, Igarashi M, Igarashi Y, Katahira T, Nagae H, Ichikawa K, Triplett DA, Koike T

    Lupus4 ( Supp 9-1 ) S13 - S17   1995年2月

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  • Relationship of microparticles with β2-glycoprotein I and P-selectin positivity to anticardiolipin antibodies in immune thrombocytopenic purpura. 査読

    Nomura S, Yanabu M, Miyake T, Miyazaki Y, Kido H, Kagawa H, Fukuhara S, Komiyama Y, Matsuura E, Koike T

    Ann Hematol70 ( 1 ) 25 - 30   1995年1月

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  • 抗リン脂質抗体症候群の病型とβ2-glycoprotein I 査読

    鏑木淳一, 桑名正隆, 山本美保子, 河合眞一, 松浦栄次, 池田康夫

    臨床血液36   1170 - 1174   1995年

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  • 抗β2-グリコプロテインI抗体 招待

    松浦栄次, 小池隆夫

    Modern Physician15   1599 - 1602   1995年

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  • β2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. 査読

    Ichikawa K, Khamashta MA, Koike T, Matsuura E, Hughes GRV

    Arthritis and Rheumatism37 ( 10 ) 1453 - 1461   1994年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • β2-Glycoprotein I-dependent and-independent anticardiolipin antibodies in healthy pregnant women. 査読

    Aoki K, Matsuura E, Sasa H, Yagami Y, Dudkiewicz AB, Gleicher N

    Human Reprod9 ( 10 ) 1849 - 1851   1994年10月

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  • ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR HUMAN PULMONARY SURFACTANT PROTEIN-D 査読

    T INOUE, E MATSUURA, A NAGATA, Y OGASAWARA, A HATTORI, Y KUROKI, S FUJIMOTO, T AKINO

    JOURNAL OF IMMUNOLOGICAL METHODS173 ( 2 ) 157 - 164   1994年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We developed a simple and sensitive enzyme-linked immunosorbent assay (ELISA) for human pulmonary surfactant protein D (SP-D). Human SP-D was purified from bronchoalveolar lavage fluids of patients with pulmonary alveolar proteinosis. Nine monoclonal antibodies (MAbs) were established from BALB/c mice immunized with the purified human SP-D. All MAbs were directed to either 43 kDa SP-D contained in lung lavage fluids of patients with pulmonary alveolar proteinosis or in amniotic fluids from healthy normal pregnancies. The ELISA is based on a sandwich method using two MAbs, 6B2 and 7C6. Cross-reactivity to human SP-A or rat SP-D was evaluated as below 0.6%. The recovery of different concentrations of SP-D ranged from 94.4% to 111.2%, and serial dilutions of amniotic fluids showed good linearity. SP-D concentrations in 21 amniotic fluids from normal pregnancies were measured by the ELISA. The mean concentration in amniotic fluids from pregnancies in the third trimester was significantly higher than that from earlier stages of gestation (p &lt; 0.001), indicating that this ELISA may be applicable for prediction of fetal lung maturity.

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  • Cofactor (β2-glycoprotein I) dependent anticardiolipin antibodies and thrombosis. 査読

    Kaburaki J, Kuwana M, Ikeda Y, Yamamoto M, Kawai S, Matsuura E

    J Rheumatol21 ( 7 ) 1371 - 1372   1994年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • β2-Glycoprotein I and anticardiolipin antibody influence factor Xa generation but not factor Xa binding to platelet-derived microperticles. 査読

    Nomura S, Fukuhara S, Komiyama Y, Takahashi H, Matsuura E, Nakagaki T, Funatsu A, Sugo T, Matsuda M, Koike T

    Thromb Haemost71 ( 4 ) 526 - 527   1994年4月

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  • Anticardiolipin antibodies recognize β2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. 査読

    Matsuura E, Igarashi Y, Yasuda T, Triplett DA, Koike T

    J Exp Med179 ( 2 ) 457 - 462   1994年2月

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  • 抗リン脂質抗体症候群 招待

    松浦栄次, 小池隆夫

    Immuno-Review11   75 - 80   1994年

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  • β2-GPI-dependent and independent binding of anticardiolipin antibodies in patients with recurrent spontaneous abortions. 査読

    Ozawa N, Makino T, Matsubayashi H, Hosokawa T, Someya K, Nozawa S, Matsuura E

    J Clin Lab Analysis8 ( 5 ) 255 - 259   1994年

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  • 抗リン脂質抗体の対応抗原 招待

    松浦栄次, 小池隆夫

    臨床免疫26   431 - 437   1994年

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  • 抗カルジオリピン抗体 招待

    松浦栄次

    Mebio11   45 - 53   1994年

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  • 抗リン脂質抗体症候群の名称は果たして妥当か 招待

    松浦栄次, 小池隆夫

    臨床免疫26   222 - 230   1994年

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  • 巨大網状皮斑、腎機能低下を呈し、シェーグレン症候群に合併した抗リン脂質抗体症候群の1例 査読

    中林 厳, 久保田孝雄, 明石好弘, 高田高志, 鈴木康史, 清水 潤, 清水栄一, 石田亜希, 西山淳一, 岡田純一, 田沢慶次, 押川泰浩, 近藤修市, 竹内昭彦, 大嶋 智, 吉澤信行, 松浦栄次

    アレルギーの臨床14   40 - 43   1994年

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  • Binding of β2-glycoprotein I to platelet-derived microparticles. 査読

    Nomura S, Komiyama Y, Matsuura E, Kokawa T, Takahashi H, Koike T

    Brit J Haematol85 ( 3 ) 640 - 640   1993年11月

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  • Expression of anticardiolipin cofactor, human β2-glycoprotein I, by a recombinant baculovirus/insect cell system. 査読

    Igarashi M, Matsuura E, Igarashi Y, Nagae H, Matsuura Y, Ichikawa K, Yasuda T, Voelker DR, Koike T

    Clin Exp Immunol93 ( 1 ) 19 - 25   1993年7月

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  • 抗リン脂質抗体症候群の臨床−内科から:cofactor (β2-glycoprotein I) 依存性抗カルジオリピン抗体の臨床的意義− 招待

    鏑木淳一, 池田康夫, 桑名正隆, 山本美保子, 川合眞一, 松浦栄次

    臨床免疫学会誌16   555 - 560   1993年

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  • 抗リン脂質抗体症候群 査読

    松浦栄次, 小池隆夫

    感染・炎症・免疫23   9 - 17   1993年

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  • 膠原病におけるcofactor(β2-glycoprotein I)依存性抗カルジオリピン抗体の疾患特異性 査読

    山本美保子, 鏑木淳一, 桑名正隆, 河合眞一, 松浦栄次, 池田康夫

    臨床血液34   879 - 881   1993年

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  • 抗リン脂質抗体の対応抗原 招待

    松浦栄次, 小池隆夫

    臨床免疫学会誌16   537 - 544   1993年

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  • Anticardiolipin antibodies in NZW × BXSB F1 mice. A model of antiphospholipid syndrome. 査読

    Hashimoto Y, Kawamura M, Ichikawa M, Suzuki T, Sumida T, Yoshida S, Matsuura E, Ikehara S, Koike T

    J Immunol149 ( 3 ) 1063 - 1068   1992年8月

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  • HETEROGENEITY OF ANTICARDIOLIPIN ANTIBODIES DEFINED BY THE ANTICARDIOLIPIN COFACTOR 査読

    E MATSUURA, Y IGARASHI, M FUJIMOTO, K ICHIKAWA, T SUZUKI, T SUMIDA, T YASUDA, T KOIKE

    JOURNAL OF IMMUNOLOGY148 ( 12 ) 3885 - 3891   1992年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER ASSOC IMMUNOLOGISTS  

    Anticardiolipin antibodies (aCL) found in sera from patients with SLE react with cardiolipin (CL) in the presence of a 50-kDa serum cofactor. The cofactor, which was identified to be beta-2-glycoprotein I by sequencing the N-terminal amino acids, not only enhances CL binding by antibodies in SLE but also depresses it by antibodies associated with syphilis. Cofactor-dependent binding of aCL in SLE to solid phase CL was competitively inhibited by the simultaneous addition of fluid phase CL but was unaffected by either prior or simultaneous addition of a high excess of the cofactor. Binding of aCL in syphilis to solid phase CL was competitively inhibited by either addition of the cofactor or fluid phase CL. aCL in SLE reacted with CL, PS, and PA in the presence of cofactor. In contrast, biotinyl-cofactor bound directly to these anionic phospholipids (PL) and also to PG. These results show that the cofactor-CL complex bears an epitope that confers recognition specificity for aCL in SLE, in contrast with direct CL recognition by syphilitic aCL. The direct binding of the cofactor to PL suggests that the cofactor dependence of aCL binding to PL is due to recognition by aCL of a unique epitope generated upon the formation of the cofactor-CL complex.

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  • 抗カルジオリピン抗体と測定法 招待

    松浦栄次, 小池隆夫

    神経内科37   542 - 550   1992年

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  • シェーグレン症候群にMLF症候群を合併した1例:SLCキットにより抗カルジオライピン抗体高値の原因が梅毒との鑑別可能であった一例 査読

    向井正也, 佐川 昭, 渥美達也, 浄土 智, 天崎吉晴, 中林 透, 渡辺一郎, 藤咲 淳, 中川昌一, 小池隆夫, 松浦栄次

    リウマチ科6   238 - 242   1992年

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  • 抗カルジオリピン抗体・コファクターの核酸配列と蛋白発現 招待

    松浦栄次, 小池隆夫

    臨床免疫24   1396 - 1403   1992年

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  • 抗カルジオリピン抗体 招待

    松浦栄次, 小池隆夫

    Chronic Disease3   399 - 403   1992年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 抗リン脂質抗体の対応抗原 招待

    松浦栄次, 小池隆夫

    臨床免疫24   207 - 214   1992年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • 抗リン脂質抗体測定法の実際 招待

    松浦栄次, 小池隆夫

    リウマチ科5   408 - 414   1992年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • β2-グリコプロテインIの新しい機能 招待

    家子正裕, 松浦栄次, 小池隆夫

    臨床検査37   794 - 796   1992年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Molecular definition of human β2-ghycoprotein I (β2-GPI) by cDNA cloning and inter-species objferences of β2-GPI in afternation of anticardiolipin binding

    Matsuura E, Igarashi M, Igarashi Y, Nagae H, Ichikawa K, Yasuda T, Koike T

    Int Immunol3 ( 12 ) 1217 - 1221   1991年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • WHAT IS THE TRUE ANTIGEN FOR ANTICARDIOLIPIN ANTIBODIES 査読

    T KOIKE, E MATSUURA

    LANCET337 ( 8742 ) 671 - 672   1991年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LANCET LTD  

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  • A SIMPLE AND SENSITIVE RADIOIMMUNOASSAY FOR ADENOSINE 査読

    R YAMANE, T NAKAMURA, E MATSUURA, H ISHIGE, M FUJIMOTO

    JOURNAL OF IMMUNOASSAY12 ( 4 ) 501 - 519   1991年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MARCEL DEKKER INC  

    We developed a simple and sensitive radioimmunoassay (RIA) for adenosine. The RIA is based on the double antibody method with adenosine 2',3'-O-disuccinyl-3-[I-125]-iodotyrosine methyl ester (diSc-adenosine-[I-125]-TME) as a tracer. Anti-adenosine antiserum for the RIA was raised in rabbits immunized with diSc-adenosine conjugated to human serum albumin (diSc-adenosine-HSA). All samples and standards were succinylated prior to assay. The present immunoassay allows detection of 6.25-400 pmol/ml of adenosine in sample. Values obtained by the RIA and by a HPLC analysis showed a high correlation with correlation coefficient of 0.997.
    In order to determine adenosine in plasmas, blood cells must be separated in the presence of 6 mM EDTA, 0.006% dipyridamole (Dip) and 23-mu-M 2'-deoxycoformycin (dCF) at 2-degrees-C. Adenosine in plasma could be accurately determined by the proposed method even without any pretreatments by deproteinizing. The adenosine levels with or without EDTA-treated normal human plasmas determined were 26.2 +/- 7.26 and 100 +/- 3.62 pmol/ml (Mean +/- SEM), respectively.

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  • 抗カルジオリピン抗体測定法の標準化 招待

    松浦栄次, 小池隆夫

    臨床免疫23   749 - 754   1991年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • ANTICARDIOLIPIN COFACTOR(S) AND DIFFERENTIAL-DIAGNOSIS OF AUTOIMMUNE-DISEASE 査読

    E MATSUURA, Y IGARASHI, M FUJIMOTO, K ICHIKAWA, T KOIKE

    LANCET336 ( 8708 ) 177 - 178   1990年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LANCET LTD  

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  • 抗リン脂質抗体の測定原理と多様性 招待

    松浦栄次, 小池隆夫

    臨床免疫22   170 - 179   1990年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Inhibition of cell proliferation with antibody-targeted liposomes containing methotrexate-γ-dimyristoyl- phosphatidylethanolamine. 査読

    Noe C, Hernandes-Borrell J, Kinsky SC, Matsuura E, Leserman L

    Biochim Biophys Acta946 ( 2 ) 253 - 260   1988年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Detection and clinical significance of acetoneinsoluble liver cell membrane antigen in sera of patients with chronic active liver diseases 査読

    Takao Tsuji, Kenji Takahashi, Masahiko Sawahara, Eiji Matsuura, Itaru Yamamoto

    Gastroenterologia Japonica20 ( 1 ) 37 - 47   1985年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer-Verlag  

    An enzyme-linked immunosorbent assay was developed to detect insoluble liver cell membrane antigen (LMAg) which gives rise to serum LMA (anti-LM) in HBsAg-negative patients. The optical density (OD) ratio of the average LMAg level of normal subjects was less than 1.2. In HBsAg-positive cases, high LMAg levels (OD ratio &gt
    2.4) were noted in 8 of 8 patients with acute hepatitis (AH), 3 of 8 with chronic persistent hepatitis (CPH), 5 of 10 with moderate chronic aggressive hepatitis (CAH), 7 of 10 severe CAH and 4 of 8 with liver cirrhosis (LC). In HBsAg-netative cases, however, high LMAg levels were noted in only 6 of 8 patients with AH, 1 of 10 with CPH, 1 of 10 with moderate CAH, 1 of 10 with severe CAH, 0 of 8 with LC, 0 of 8 with fatty liver and 5 of 10 with alcoholic hepatitis. In micro-immunodiffusion experiments, intensively absorbed rabbit anti-rat LM precipitated two organ-specific components of rat liver homogenate, one of which was identical to liver specific protein (LSP). In immunohistochemical demonstrations of LMAg and LSP, anti-LM, prepared from the serum of a HBsAg-negative CAH patient, bound to both human and rat acetone-fixed liver cell membranes, but not to those of human or rat kidneys. Absorbed rabbit anti-rat LM also bound to liver cell membranes, but absorbed anti-rat LSP lacked organ-specificity when assayed with the immunofluorescence technique using acetone-fixed liver sections. In conclusion, the appearance of serum LMAg was associated with high-SGPT patients and HBsAg-positive CAH patients. © 1985 The Japanese Society of Gastroenterology.

    DOI: 10.1007/BF02774672

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  • SHR脾細胞のCon A応答 査読

    山本 格, 山口知栄子, 山内 宏, 松浦栄次, 辻 淳一

    消化器と免疫14   37 - 40   1985年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Monoclonal antibody for calcitriol (1α, 25-dihydroxyvitamin D3). 査読

    Yamamoto I, Matsuura E

    J Biochem98 ( 4 ) 991 - 998   1985年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • ENZYME-IMMUNOASSAY FOR MABUTEROL, A SELECTIVE BETA-2-ADRENERGIC STIMULANT IN THE TRACHEA 査読

    YAMAMOTO, I, E MATSUURA, M HORIBA, K AKIMA, K NOMURA, T AIZAWA

    JOURNAL OF IMMUNOASSAY6 ( 3 ) 261 - 276   1985年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MARCEL DEKKER INC  

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  • Immunoregulatory α-globulinのリンパ球幼若化反応および実験的慢性関節炎抑制作用 査読

    松浦栄次, 土本雅弘, 山口知栄子, 末吉俊幸, 杉江邦夫, 辻 淳一, 山本 格

    消化器と免疫14   46 - 49   1985年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • AN EXPERIMENTAL-MODEL OF NEPHRITIS INDUCED BY CALF SERUM INJECTION IN MICE 査読

    M TSUCHIMOTO, K KOMORIYA, T KOYAMA, K HOSODA, T TAKESHITA, T NARUCHI, E MATSUURA, YAMAMOTO, I

    JAPANESE JOURNAL OF PHARMACOLOGY36 ( 2 ) 223 - 234   1984年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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▼全件表示

書籍等出版物

  • The Heart in Systemic Autoimmune Diseases (Second edition)

    Matsuura E, Tan XW, Shen LH, Nuriza UA, Lopez LR( 担当: 分担執筆 ,  範囲: Inflammasomes and inflammatory cytokines in early atherosclerosis)

    Elsevier Science BV, Amsterdam, The Netherlands  2017年 

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  • Autoantibodies (Third edition)

    Matsuura E, Lopez LR( 担当: 分担執筆 ,  範囲: Anti-β2-glycoprotein I antibodies)

    Elsevier Science BV, Amsterdam, The Netherlands  2012年 

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  • 平成18年度~19年度科学研究費補助金(基盤研究C)研究成果報告書

    松浦栄次( 担当: 単著 ,  範囲: 感染による動脈硬化の進展とその抑制に関する病態生化学的・免疫学的解析)

    2008年 

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  • 日本テンペ研究会誌

    松浦栄次( 担当: 分担執筆 ,  範囲: テンペと生活習慣病)

    2007年 

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  • Autoantibodies (Second edition)

    Matsuura E, Dier K, Lopez LR( 担当: 分担執筆 ,  範囲: Anti-β2-glycoprotein I antibodies)

    Elsevier B.V.,Amsterdam, Netherlands.  2007年 

     詳細を見る

  • 平成16年度〜平成17年度バイオアクティブおかやま委託研究事業成果報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 「テンペ」の脂質代謝の改善(抗動脈硬化)食品としての実用化研究)

    2006年 

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  • 平成16-17年度文部科学省科学研究補助金(萌芽研究)研究成果報告書

    松浦栄次( 担当: 単著 ,  範囲: “タンパク質”修飾酸化LDLの診断法の確と動脈硬化における意義に関する研究)

    2006年 

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  • 厚生労働科学研究費補助金難治性疾患克服研究事業平成15年度-平成17年度総合研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: PBCマウスモデルの作製に関する研究.難治性自己免疫性肝疾患の画期的治療法の開発に関する臨床研究)

    2006年 

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  • Hughes Syndrome: Antiphospholipid Syndrome (Second Edition)

    Matsuura E, Kobayashi K, Lopez LR( 担当: 分担執筆 ,  範囲: Atherogenesis and antiphospholipid antibodies)

    Springer, London, UK  2006年 

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  • 自己抗体と自己免疫

    松浦栄次( 担当: 分担執筆 ,  範囲: 酸化LDL・β2-glycoprotein I複合体と動脈硬化性疾患)

    医学生物学研究所、名古屋  2006年 

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  • 図説ARTマニュアル、改訂第2版

    小林和子, 井上勝美, 保田晋助, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗リン脂質抗体症候群)

    永井書店、大阪  2005年 

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  • 厚生労働科学研究費補助金難治性疾患克服研究事業平成16年度研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: LDLの変性およびタンパク質修飾:免疫が関与する動脈硬化の進展機序と早期診断法.自己免疫疾患に関する調査研究)

    2005年 

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  • Systemic Lupus Erythematosus (Fourth Edition)

    Atsumi T, Matsuura E, Koike T( 担当: 分担執筆 ,  範囲: Immunology of antiphospholipid antibodies and cofactors)

    Elsevier Science BV, Amsterdam, The Netherlands  2004年 

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  • Recent Research of Developments in Lipids (Vol 7)

    Lopez LR, Matsuura E( 担当: 分担執筆 ,  範囲: Autoimmune-mediated atherosclerosis: pathogenic role of oxLDL/β2GPI complexes)

    Transworld Research Network,Kerala  2004年 

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  • 三共生命科学研究振興財団研究助成報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 酸化ストレスにより誘導される酸化LDL・β2-グリコプロテインI複合体の病因的意義)

    2004年 

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  • 厚生科学研究費補助金特定疾患対策研究事業平成15年度研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 抗リン脂質抗体症候群の診断法に関する検討.自己免疫疾患に関する調査研究)

    2004年 

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  • Autoantigens, Autoantibodies, Autoimmunity (Vol 4)

    Inagaki J, Kondo A, Lopez LR, Shoenfeld Y, Matsuura E( 担当: 分担執筆 ,  範囲: Anti-laminin-1 autoantibodies in reproductive failure: animal and human studies)

    Pabst Science Publisher, Lengerich, Germany  2004年 

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  • 平成14-15年度文部科学省科学研究補助金 (基盤研究(C)(2)) 研究成果報告書

    松浦栄次( 担当: 単著 ,  範囲: 抗リン脂質抗体症候群におけるマクロファージの役割:抗原提示および血栓形成の機序)

    2004年 

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  • 厚生科学研究費補助金特定疾患対策研究事業平成14年度研究報告書

    松浦栄次, 小池隆夫( 担当: 分担執筆 ,  範囲: 抗リン脂質抗体症候群の診断法:酸化LDL・β2-グリコプロテイン I 複合体(自己抗原)とそれらの免疫複合体の測定意義.自己免疫疾患に関する調査研究)

    2003年 

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  • 厚生科学研究費補助金特定疾患対策研究事業平成11-13年度研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 自己免疫疾患の病因・病態解析と新たな治療法の開発に関する研究)

    2003年 

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  • アニムス

    松浦栄次, 小林和子( 担当: 分担執筆 ,  範囲: 酸化LDL研究の現状)

    アニムス刊行会  2003年 

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  • 平成9年度〜平成12年度文部省科学研究費(特定領域研究 A1) 動脈硬化の分子機構研究成果報告書

    松浦栄次, 小池隆夫( 担当: 分担執筆 ,  範囲: 新規酸化LDLリガンドと自己抗体が関与する動脈硬化の発症機序に関する研究)

    2002年 

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  • 厚生科学研究費補助金特定疾患対策研究事業平成13年度研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 酸化LDLの測定法と抗リン脂質抗体症候群における酸化LDLの臨床意義に関する研究.自己免疫疾患の病因・病態解析と新たな治療法の開発に関する研究)

    2002年 

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  • 血小板と生理活性脂質

    小林和子, 近藤朱音, 松浦栄次( 担当: 分担執筆 ,  範囲: 脂質の酸化と生理活性)

    金芳堂  2002年 

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  • 厚生科学研究費補助金特定疾患対策研究事業平成12年度研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 病因となる自己抗体の検出とその臨床意義:抗β2-GPI抗体、抗 laminin-1抗体、および抗sulfatide抗体.自己免疫疾患の病因・病態解析と新たな治療法の開発に関する研究)

    2001年 

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  • Atherosclerosis and Autoimmunity

    Matsuura E, Kobayashi K, Kasahara J, Kaihara K, Shoenfeld Y, Koike T( 担当: 分担執筆 ,  範囲: Oxidized autoantigens in atherosclerosis)

    Elsevier Science BV, Amsterdam, The Netherlands  2001年 

     詳細を見る

  • 生体機能分子データブック

    松浦栄次( 担当: 分担執筆 ,  範囲: 自己抗原・自己抗体)

    中外医学社、東京  2001年 

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  • 厚生科学研究費補助金特定疾患対策研究事業平成11年度研究報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 抗リン脂質抗体症候群における自己抗体の関与した動脈硬化の発症機序の解明.自己免疫疾患の病因・病態解析と新たな治療法の開発に関する研究)

    2000年 

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  • Systemic Lupus Erythematosus (Third Edition)

    Koike T, Matsuura E( 担当: 分担執筆 ,  範囲: Immunology of anti-phospholipid antibodies)

    Academic Press, New York, USA  1999年 

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  • 厚生省特定疾患免疫疾患調査研究班自己免疫疾患分科会.平成10年度報告書

    小池隆夫, 市川健司, 堤 明人, 渥美達也, 松浦栄次, 小林清一( 担当: 分担執筆 ,  範囲: IgG抗カルジオリピン抗体測定系の標準となりうる、ヒトIgG型キメラ抗体の作成)

    1999年 

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  • 平成9年度厚生省厚生科学研究費補助金感覚器障害及び免疫・アレルギー等研究事業研究成果報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: 免疫・アレルギー性疾患の症状発現および増悪に関する研究)

    1999年 

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  • The Medical Bulletin(The Ryouichi Naito Foundation for Medical Research)

    松浦栄次( 担当: 分担執筆 ,  範囲: 抗リン脂質抗体症候群における血管病変の発症機序の解明)

    内藤医学研究振興財団  1999年 

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  • The Decade of Autoimmunity

    Koike T, Matsuura E( 担当: 分担執筆 ,  範囲: Anticardiolipin antibody, thrombosis and atherosclerosis)

    Elsevier Science B.V. Amsterdam, The Netherlands  1999年 

     詳細を見る

  • 厚生省特定疾患調査研究班免疫疾患調査研究班平成9年度報告書

    小池隆夫, 市川健司, 笠原英樹, 堤 明人, 渥美達也, 松浦栄次, 山本大助( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体が認識するアミノ酸配列の解析)

    1998年 

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  • 臨床免疫学

    松浦栄次, 小池隆夫( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体)

    朝倉書店、東京  1997年 

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  • 文部省がんに係る重点領域研究平成8年度報告書

    西 信三, 酒井正春, 小山芳一, 松浦栄次( 担当: 分担執筆 ,  範囲: 発生工学を応用した α-フェトプロテインの糖鎖構造及び機能の解析)

    1997年 

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  • 厚生省特定疾患調査研究班免疫疾患調査研究班平成8年度報告書

    小池隆夫, 松浦栄次, 北川浩彦, 市川健司, 堤 明人, 西 信三( 担当: 分担執筆 ,  範囲: β2-グリコプロテインI (β2-GPI) および抗β2-GPI抗体の動脈硬化およびアポトーシスへの関与)

    1997年 

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  • 厚生省特定疾患自己免疫疾患調査研究班平成8年度報告書

    小池隆夫, 堤 明人, 市川健司, 松浦栄次, 小林清一( 担当: 分担執筆 ,  範囲: 全身性エリテマトーデス患者血清中の抗β2-GPI抗体の臨床的意義)

    1997年 

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  • 別冊・医学のあゆみ「全身性エリテマトーデス」

    松浦栄次, 小池隆夫( 担当: 分担執筆)

    医歯薬出版、東京  1997年 

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  • 1995年度国際血栓止血学会SSC報告書

    松浦栄次( 担当: 分担執筆 ,  範囲: Subcommittee on Lupus Anticoagulants and Phospholipid-Dependent Antibodies)

    血栓止血情報センター  1996年 

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  • 厚生省特定難治性血管炎調査研究班1995年度報告書

    小池隆夫, 牧田善二, 蓮沼祐子, 松浦栄次, 片平智禎( 担当: 分担執筆 ,  範囲: β2-グリコプロテインIおよび自己抗体による酸化LDL取り込みの制御)

    1996年 

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  • Autoantibodies

    Matsuura E, Koike T( 担当: 分担執筆 ,  範囲: β2-Glycoprotein I antibodies)

    Elsevier Science BV, Amsterdam, The Netherlands  1996年 

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  • 厚生省特定疾患自己免疫疾患調査研究班平成6年度報告書(2)

    小池隆夫, 堤 明人, 市川健司, 小林清一, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体の新しい測定法の開発)

    1995年 

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  • 厚生省特定疾患自己免疫疾患調査研究班平成6年度報告書(1)

    小池隆夫, 市川健司, 堤 明人, 松浦栄次( 担当: 分担執筆 ,  範囲: β2-グリコプロテインI上のリン脂質結合部位と抗原決定基の分子生物学的解析)

    1995年 

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  • 厚生省特定難治性血管炎調査研究班1994年度報告書

    小池隆夫, 堤 明人, 市川健司, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体と酸化LDL)

    1995年 

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  • 厚生省特定疾患自己免疫疾患調査研究班平成5年度研究報告

    小池隆夫, 市川健司, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗リン脂質抗体症候群患者より樹立したモノクローナル抗カルジオリピン抗体の特異性の検討)

    1994年 

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  • 免疫93-94

    小池隆夫, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体とその対応抗原)

    中山書店、東京  1993年 

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  • 自己免疫とトレランス

    小池隆夫, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体)

    中外医学社、東京  1993年 

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  • 厚生省特定疾患自己免疫疾患調査研究班平成4年度研究報告書

    小池隆夫, 松浦栄次, 住田孝之( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体の対応抗原)

    1993年 

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  • Interactable Vasculitis

    Koike T, Matsuura E( 担当: 分担執筆 ,  範囲: Anticardiolipin antibody and β2-glycoprotein I)

    University Press, Sapporo, Japan,  1993年 

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  • 厚生省特定疾患自己免疫疾患調査研究班平成2年度研究報告書

    小池隆夫, 市川健二, 鈴木隆弘, 住田孝之, 藤本正雄, 五十嵐佳子, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体測定系の確立)

    1991年 

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  • 厚生省特定疾患系統的脈管障害調査研究班・自己免疫疾患調査研究班平成元年度合同シンポジウム報告書

    小池隆夫, 市川健司, 石原貞子, 佐藤俊子, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体の測定)

    1990年 

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    記述言語:英語

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  • 厚生省特定疾患系統的脈管障害調査研究班・自己免疫疾患調査研究班平成元年度合同シンポジウム報告書

    小池隆夫, 市川健司, 石原貞子, 佐藤俊子, 松浦栄次( 担当: 分担執筆 ,  範囲: 抗カルジオリピン抗体の測定)

    1990年 

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    記述言語:英語

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▼全件表示

MISC

  • Tracking and Imaging of Tumor Progression and Immune Function in a Preclinical Mouse Model

    Peng Huang, Naijin Xu, Eiji Matsuura, Masami Watanbe, Hiromi Kumon, Yasutomo Nasu, Chunxiao Liu

    MOLECULAR THERAPY25 ( 5 ) 98 - 98   2017年5月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:CELL PRESS  

    Web of Science

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  • SIGNIFICANT ACCUMULATION OF OXLDL/BETA2-GLYCOPROTEIN I COMPLEXES IN ARTERIAL LESIONS OF WHHL RABBITS: PET/CT IMAGING USING AN AUTO ANTIBODY'S SCFV VARIANT

    T. Sasaki, Y. Matsunami, F. Takenaka, S. Kita, H. Hirano, L. Shen, K. Kobayashi, E. Matsuura

    ATHEROSCLEROSIS235 ( 2 ) E68 - E68   2014年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • CIRCULATING PRO-ATHEROGENIC OXIDIZED-LDL/beta 2-GLYCOPROTEIN I COMPLEXES ARE DETECTED IN ARTERIAL AND VENOUS DISEASES AND ARE INDEPENDENT PREDICTORS OF CAROTID ARTERIAL DISEASE

    L. R. Lopez, E. Matsuura, K. E. Guyer, C. B. Rockman, J. S. Berger

    ATHEROSCLEROSIS235 ( 2 ) E218 - E218   2014年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

    Web of Science

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  • Elucidation of the pharmacokinetic difference of regioisomeric retinoid X receptor agonists having an alkoxy group by PET imaging

    Toshiki Kobayashi, Kohei Kawata, Mariko Nakayama, Yuki Furusawa, Shoya Yamada, Hiroyuki Hirano, Fumiaki Takenaka, Masaru Akehi, Takanori Sasaki, Eiji Matsuura, Akihiro Tai, Hiroki Kakuta

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY248   2014年8月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:AMER CHEMICAL SOC  

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  • PETイメージングを用いたアルコキシ基を有するレチノイドX受容体アゴニストの体内動態解析

    加来田 博貴, 小林 俊貴, 古沢 優貴, 山田 翔也, 竹中 文章, 明日 卓, 佐々木 崇了, 松浦 栄次, 田井 章博

    ビタミン88 ( 4 ) 213 - 213   2014年4月

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    記述言語:日本語   出版者・発行元:(公社)日本ビタミン学会  

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  • アルコキシ基を有するレチノイドX受容体アゴニストの位置異性体間における体内動態差の解明とその応用

    小林 俊貴, 古沢 優貴, 山田 翔也, 平野 裕之, 竹中 文章, 明日 卓, 佐々木 崇了, 松浦 栄次, 田井 章博, 加来田 博貴

    日本薬学会年会要旨集134年会 ( 4 ) 81 - 81   2014年3月

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    記述言語:日本語   出版者・発行元:(公社)日本薬学会  

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  • Atherosclerosis in primary antiphospholipid syndrome: Summary of clinical and pathogenic evidence

    P. R J Ames, L. R. Lopez, E. Matsuura, A. Margarita

    Journal of Clinical and Experimental Cardiology5 ( 2 )   2014年

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:OMICS Publishing Group  

    The Antiphospholipid Syndrome (APS) was described in the early '80s as a combination of thrombosis, thrombocytopenia and recurrent miscarriages associated with persistent high titers of Antiphospholipid Antibodies (aPL). In subsequent years, it became apparent that aPL were also associated with premature atherosclerosis in Systemic Lupus Erythematosus (SLE) and more recently in primary APS (PAPS). The studies exploring atherosclerosis in PAPS were heterogeneous in conception and size, but overall, provided enough evidence that Intima Media Thickness (IMT) of carotid arteries and endothelial function are abnormal in PAPS. In keeping with the general view that atherosclerosis is a low grade inflammatory and "auto"immune disorder characterized by oxidative and nitrative stress, several studies have confirmed similar findings in PAPS, though a specific relation with the severity of atherosclerosis is lacking. Given its development at an earlier age than average, atherosclerosis should be taken into account in the overall management of PAPS patients as it may significantly add to the vascular risk. © 2014 Ames PRJ, et al.

    DOI: 10.4172/2155-9880.1000293

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  • Aspirin inhibition of thromboxane does not affect oxidative stress, nitric oxide metabolites, paraoxonase activity or P-selectin levels in diabetes

    L. R. Lopez, J. R. Batuca, I. J. Muncy, I. Garcia De La Torre, E. Matsuura, P. R. J. Ames

    DIABETOLOGIA54   S305 - S305   2011年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SPRINGER  

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  • Simultaneous occurrence of natural immunity, atherogenic in vivo LDL oxidation and thromboxane-mediated platelet activation in atherosclerosis-prone (LDLR-/- and apoE-/-) mice

    E. Matsuura, L. Shen, Y. Matsunami, N. Quan, K. Kobayashi, Y. Shoenfeld, K. Oguma, L. R. Lopez

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS9   906 - 906   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • Distinctive aspirin effect on the arachidonic acid pathway, oxidative stress, nitric oxide metabolites and P-selectin in diabetes mellitus

    L. R. Lopez, Muncy, I, E. Matsuura, J. Batuca, K. Guyer, I. G. De La Torre, P. R. J. Ames

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS9   338 - 339   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • Anti-atherogenic plaque reduction, inhibition of oxLDL/B2GPI autoantigen and thromboxane platelet activation by persimmon (diospyros Kaki) peel in LDLR-/- deficient mice

    E. Matsuura, N. Quan, K. Kobayashi, Y. Matsunami, M. Ide, M. Makarova, L. Shen, S. Ohno, Y. Zheng, H. Kobayashi, L. R. Lopez

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS9   906 - 907   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • Rosuvastatin decreases serum levels of oxidized low-density lipoprotein/beta2-glycoprotein I complex through the nitric oxide pathway in diabetes mellitus

    L. R. Lopez, E. Matsuura, J. Batuca, I. G. De La Torre, P. R. J. Ames

    JOURNAL OF THROMBOSIS AND HAEMOSTASIS9   650 - 650   2011年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • ANTI-ATHEROGENIC EFFECTS OF PERSIMMON (DIOSPYROS KAKI) PEEL IN LDLR-/--DEFICIENT MICE: PLAQUE REDUCTION, INHIBITION OF OXLDL/beta 2GPI AUTOANTIGEN AND THROMBOXANE PLATELET ACTIVATION

    E. Matsuura, N. Quan, K. Kobayashi, Y. Matsunami, M. Ide, M. Makarova, L. Shen, S. Ohno, Y. Zheng, H. Kobayashi, L. R. Lopez

    ATHEROSCLEROSIS SUPPLEMENTS12 ( 1 ) 52 - 52   2011年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • ATHEROGENIC IN VIVO LDL OXIDATION, THROMBOXANE-MEDIATED PLATELET ACTIVATION AND SIMULTANEOUS OCCURRENCE OF NATURAL IMMUNITY IN ATHEROSCLEROSIS-PRONE (LDLR-/- AND APOE(-/-)) MICE

    E. Matsuura, L. Shen, Y. Matsunami, N. Quan, K. Kobayashi, Y. Shoenfeld, K. Oguma, L. R. Lopez

    ATHEROSCLEROSIS SUPPLEMENTS12 ( 1 ) 85 - 85   2011年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • Nicked β2-Glycoprotein I と Angiostatin Kringle 1-4.5 の血管新生に与える影響

    中川 久子, 保田 晋助, 松浦 栄次, 小林 和子, 家子 正裕, 片岡 浩, 堀田 哲也, 渥美 達也, 小池 隆夫

    日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis21 ( 3 ) 314 - 318   2010年6月

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    記述言語:日本語   出版者・発行元:日本血栓止血学会  

    DOI: 10.2491/jjsth.21.314

    CiNii Article

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  • OXIDIZED-LDL/beta 2-GLYCOPROTEIN I COMPLEXES AND ANTIPHOSPHOLIPID ANTIBODIES ARE ASSOCIATED WITH DISEASE SEVERITY AND RISK FOR ADVERSE OUTCOMES IN ACUTE CORONARY SYNDROME

    L. Lopez, T. Greco, A. M. Conti-Kelly, R. Anthony, J. Geske, M. Boisen, E. Matsuura

    ATHEROSCLEROSIS SUPPLEMENTS11 ( 2 ) 41 - 41   2010年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • ROSUVASTATIN PROMOTES ANTIOXIDANT EFFECT THROUGH NITRIC OXIDE PATHWAY AND REDUCES SERUM LEVELS OF OXIDIZED-LDL/beta 2GPI COMPLEXES IN PATIENTS WITH DIABETES MELLITUS

    L. Lopez, P. Ames, J. Batuca, I. Garcia De la Torre, K. Kojima, E. Matsuura

    ATHEROSCLEROSIS SUPPLEMENTS11 ( 2 ) 68 - 68   2010年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:ELSEVIER IRELAND LTD  

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  • Low grade inflammation and in vivo immune activation in primary antiphospholipid syndrome

    Paul R. Ames, Antonio Ciampa, Eiji Matsuura, Luis Lopez, Giovanna Scenna, Iolanda Antinolfi, Luigi Iannaccone, Felicetto Ferrara

    RHEUMATOLOGY47   II93 - II94   2008年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:OXFORD UNIV PRESS  

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  • Distinguished effects of antiphospholipid antibodies and anti-oxidized LDL antibodies on oxidized LDL uptake by macrophages (vol 16, pg 929, 2007)

    K. Kobayashi, K. Tada, H. Itabe, T. Ueno, P-H Liu, A. Tsutsumi, M. Kuwana, T. Yasuda, Y. Shoenfeld, P. G. de Groot, E. Matsuura

    LUPUS17 ( 1 ) 75 - 75   2008年1月

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    記述言語:英語   出版者・発行元:SAGE PUBLICATIONS LTD  

    DOI: 10.1177/0961203307087668

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  • Atherosclerosis in primary antiphospholipid syndrome

    P. R. J. Ames, A. Margarita, L. Lopez, E. Matsuura, I. Antinolfi, G. Scenna

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY25 ( 2 ) 132 - 132   2007年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:CLINICAL & EXPER RHEUMATOLOGY  

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  • C-reactive protein in primary antiphospholipid syndrome

    P. R. J. Ames, A. Ciampa, G. Scenna, I. Antinolfi, L. Lopez, E. Matsuura

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY25 ( 2 ) 132 - 132   2007年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:CLINICAL & EXPER RHEUMATOLOGY  

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  • Antiphospholipid antibodies in patients with coronary artery disease: New cardiac risk factors?

    T. P. Greco, A. M. Cont-Kelly, T. P. Greco, K. Dier, E. Matsuura, L. R. Lopez

    CLINICAL AND EXPERIMENTAL RHEUMATOLOGY25 ( 2 ) 133 - 133   2007年3月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:CLINICAL & EXPER RHEUMATOLOGY  

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  • Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis

    Eiji Matsuura, Kazuko Kobayashi, Masako Tabuchi, Luis R. Lopez

    PROGRESS IN LIPID RESEARCH45 ( 6 ) 466 - 486   2006年11月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Oxidized low-density lipoprotein (oxLDL) is thought to promote atherosclerosis through complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and foam cell formation. Recent findings suggested that oxLDL forms complexes with beta(2)-glycoprotein I (beta(2)GPI) and/or C-reactive protein (CRP) in the intima of atherosclerotic lesions. Autoantibodies against oxLDL/beta 2GPI complexes occur in patients with systemic lupus erythematosus (SLE) and/or anti-phospholipid syndrome (APS) and significantly correlate with arterial thrombosis. IgG autoantibodies having similar specificity emerged spontaneously in non-immunized NZW x BXSB F1 mice, an animal model of APS, and a monoclonal autoantibody (WB-CAL-1; IgG2a) against complexed beta(2)GPI (oxLDL/beta 2GPI complexes) was derived from the same mice. WB-CAL-1 significantly increased the in vitro uptake of oxLDL/P2GPI complexes by macrophages. This observation strongly suggests that such IgG autoantibodies are pro-atherogenic. In contrast, IgM anti-oxLDL natural antibodies found in the atherosclerosis-prone mice (ApoE(-/-) and LDL-R-/- mice) have been proposed to be anti-atherogenic (protective). The presence of IgG anti-oxLDL antibodies in humans has been documented in many publications but their exact clinical significance remains unclear. In this article, we review recent progress in our understanding of the mechanisms involved in oxidation of LDL, formation of oxLDL complexes, and antibody mediated-immune regulation of atherogenesis. (c) 2006 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.plipres.2006.05.001

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  • Excessive exposure to anionic surfaces maintains autoimmune response to ss 2-glycoprotein I in patients with antiphospholipid syndrome.

    Yukie Yamaguchi, Noriyuki Seta, Yuka Okazaki, Junichi Kaburaki, Eiji Matsuura, Masataka Kuwana

    ARTHRITIS AND RHEUMATISM54 ( 9 ) S561 - S562   2006年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • INCREASE OF SERUM ANGIOPOIETIN-2 DURING PREGNANCY IS AMELIORATED IN WOMEN WITH PREECLAMPSIA

    Kumiko Hirokoshi, Yohei Maeshima, Hitoshi Sugiyama, Yasushi Yamasaki, Hirofumi Makino, Kazuko Kobayashi, Eiji Matsuura, Hisashi Masuyama, Yuji Hiramatsu

    NEPHROLOGY10   A103 - A103   2005年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-BLACKWELL  

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  • Nicked beta2-glycoprotein I binds to plasminogen and plays a role in extrinsic fibrinolysis via negative feedback mechanism

    S Yasuda, T Atsumi, M Ieko, E Matsuura, Y Amasaki, T Koike

    ARTHRITIS AND RHEUMATISM50 ( 9 ) S640 - S640   2004年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • ANTIBODIES AGAINST OXIDISED THE COMPLEX LOW DENSITY LIPOPROTEIN-BETA-2-GLYCOPROTEIN-I MAY HAVE A PRO-ATHEROGENIC ROLE IN PRIMARY ANTIPHOSPHOLIPID SYNDROME

    P. R. J. Ames, J. Delgado-Alves, D. Lopez, L. Lopez, E. Matsuura, A. Margarita, L. Iannaccone, V. Brancaccio

    RHEUMATOLOGY43   109 - 109   2004年4月

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  • Circulating oxLDL/beta(2)GPI complexes in autoimmune diseases: Pathogenic implications for systemic lupus erythematosus and systemic sclerosis

    LR Lopez, K Dier, B Hurley, J Kuca, C Fink, E Matsuura

    THROMBOSIS RESEARCH114 ( 5-6 ) 653 - 653   2004年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

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  • T lymphocyte subsets in primary antiphospholipid syndrome

    C Tommasino, G Fossati, LR Lopez, E Matsuura, A Margarita, G Scenna, Brancaccio, V, PRJ Ames

    THROMBOSIS RESEARCH114 ( 5-6 ) 612 - 612   2004年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

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  • The relationship of oxLDL, beta(2)GPI and beta(2)GPI-oxLDL complexes in patients with APS

    A Ambrozic, T Kveder, B Rozman, E Matsuura

    THROMBOSIS RESEARCH114 ( 5-6 ) 646 - 647   2004年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

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  • Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells.

    M Kuwana, Y Okazaki, J Kaburaki, Y Kawakami, E Matsuura

    ARTHRITIS AND RHEUMATISM48 ( 9 ) S446 - S446   2003年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • Anti-idiotypes against oxidized LDL antibodies intravenious immunoglobulin preparations explanation for its immunomodulatory effects in atherosclerosis

    Y Sherer, R Wu, E Matsuura, B Gilburd, T Koike, JB Peter, Y Shoenfeld

    ANNALS OF THE RHEUMATIC DISEASES62   125 - 126   2003年7月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:B M J PUBLISHING GROUP  

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  • 抗リン脂質抗体症候群における血栓形成機序 酸化LDL-β2-グリコプロテインI複合体の自己抗原としての意義

    松浦 栄次, 小林 和子, 貴志 周, 渥美 達也, 稲垣 純子, 山本 格, 保田 立二, 小池 隆夫

    日本免疫学会総会・学術集会記録32   208 - 208   2002年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本免疫学会  

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  • Antigenic levels and autoantibodies to oxidized-LDL in patients with antiphospholipid syndrome.

    D Lopez, KJ Dier, CA Fink, LR Lopez, JT Merrill, E Matsuura

    ARTHRITIS AND RHEUMATISM46 ( 9 ) S219 - S219   2002年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • Oxidized LDL, not anti-oxidized LDL, predicts coronary calcification.

    M Petri, Y Shoenfeld, E Matsuura

    ARTHRITIS AND RHEUMATISM46 ( 9 ) S54 - S54   2002年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • β2-グリコプロテイン1に対する自己抗体の動脈血栓発症への関与

    小林 和子, 松浦 栄次, 劉 慶平, 笠原 順子, 稲垣 純子, 保田 立二, 小池 隆夫

    リウマチ42 ( 2 ) 271 - 271   2002年3月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • A chimeric antibody as a putative standard for assays to detect IgA anticardiolipin and anti-beta 2-glycoprotein 1 antibodies.

    K Ichikawa, T Atsumi, E Matsuura, Y Amasaki, T Koike

    ARTHRITIS AND RHEUMATISM44 ( 9 ) S147 - S147   2001年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:WILEY-LISS  

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  • 抗リン脂質抗体症候群患者血清中に抗スルファチド抗体の特異性

    貝原 恵子, 松浦 栄次, 小林 和子, 稲垣 純子, 劉 慶平, 保田 立二, 宮脇 昌二, 小池 隆夫

    リウマチ41 ( 2 ) 392 - 392   2001年4月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • 抗リン脂質抗体症候群における動脈硬化発症への酸化コレステロールエステルの関与

    小林 和子, 松浦 栄次, 劉 慶平, 貝原 恵子, 稲垣 純子, 保田 立二, 小池 隆夫

    リウマチ41 ( 2 ) 391 - 391   2001年4月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • 抗リン脂質抗体症候群における血中酸化LDLの臨床的意義

    笠原 順子, 松浦 栄次, 趙 丹丹, 小林 和子, 劉 慶平, 貝原 恵子, 稲垣 純子, 保田 立二, 槇野 博史

    日本免疫学会総会・学術集会記録30   108 - 108   2000年11月

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    記述言語:日本語   出版者・発行元:(NPO)日本免疫学会  

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  • 自己免疫疾患患者おける抗スルファチド抗体の出現 SLE及び抗リン脂質抗体症候群における解析

    貝原 恵子, 松浦 栄次, 小林 和子, 稲垣 純子, 劉 慶平, 保田 立二, 宮脇 昌二, 小池 隆夫

    日本免疫学会総会・学術集会記録30   107 - 107   2000年11月

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    記述言語:日本語   出版者・発行元:(NPO)日本免疫学会  

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  • 抗リン脂質抗体症候群における動脈血栓への抗β2-グリコプロテインI自己抗体の関与

    小林 和子, 松浦 栄次, 劉 慶平, 貝原 恵子, 稲垣 純子, 保田 立二, 小池 隆夫

    日本免疫学会総会・学術集会記録30   107 - 107   2000年11月

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    記述言語:日本語   出版者・発行元:(NPO)日本免疫学会  

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  • Valine/leucine(247) polymorphism of beta 2-glycoprotein 1 affects the reactivity of anti-beta 2-glycoprotein 1 antibodies.

    S Yasuda, T Atsumi, K Ichikawa, E Matsuura, K Kaihara, T Yasuda, Y Amasaki, T Koike

    ARTHRITIS AND RHEUMATISM43 ( 9 ) S404 - S404   2000年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 抗β2-グリコプロテインI・酸化LDL抗体による動脈硬化の発症機序

    小林 和子, 松浦 栄次, 劉 慶平, 貝原 恵子, 稲垣 純子, 保田 立二, 小池 隆夫

    リウマチ40 ( 2 ) 385 - 385   2000年4月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • 自己抗原の発現に関与するβ2-グリコプロテインIのドメインIV-V間の相互作用

    貝原 恵子, 松浦 栄次, 山本 大助, 小林 和子, 稲垣 純子, 劉 慶平, 保田 立二, 小池 隆夫

    リウマチ40 ( 2 ) 387 - 387   2000年4月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • cryptic epitopeの発現に関与するβ2-グリコプロテインIのドメインIV-V間の相互作用

    貝原 恵子, 松浦 栄次, 山本 大助, 小林 和子, 稲垣 純子, 劉 慶平, 保田 立二, 小池 隆夫

    日本免疫学会総会・学術集会記録29   35 - 35   1999年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本免疫学会  

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  • 抗β2-グリコプロテインI抗体の動脈硬化への関与I.酸化LDL由来のリガンドの精製と自己抗体の反応性

    松浦 栄次, 小林 和子, 劉 慶平, 貝原 恵子, 稲垣 純子, 保田 立二, 小池 隆夫

    日本免疫学会総会・学術集会記録29   35 - 35   1999年10月

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    記述言語:日本語   出版者・発行元:(NPO)日本免疫学会  

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  • A chimeric antibody with the human gamma 1 constant region as a putative standard for assays to detect IgG anticardiolipin and anti-beta 2-glycoprotein 1 antibodies.

    K Ichikawa, A Tsutsumi, T Atsumi, E Matsuura, S Kobayashi, T Koike

    ARTHRITIS AND RHEUMATISM42 ( 9 ) S367 - S367   1999年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 抗リン脂質抗体の動脈硬化の進展への関与

    小林 和子, 松浦 栄次, 稲垣 純子, 貝原 恵子, 保田 立二, 小池 隆夫

    リウマチ39 ( 2 ) 322 - 322   1999年4月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • plasminによる限定分解 自己抗原であるβ2-グリコプロテイン1の抗原性の消失

    松浦 栄次, 稲垣 純子, 小林 和子, 貝原 恵子, 保田 立二, 笠原 英樹, 市川 健司, 堤 明人, 小池 隆夫

    リウマチ39 ( 2 ) 323 - 323   1999年4月

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    記述言語:日本語   出版者・発行元:(一社)日本リウマチ学会  

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  • IgA class anti-beta(2)-glycoprotein I in patients with systemic lupus erythematosus - Reply

    A Tsutsumi, E Matsuura, K Ichikawa, T Koike

    JOURNAL OF RHEUMATOLOGY25 ( 11 ) 2283 - 2284   1998年11月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:J RHEUMATOL PUBL CO  

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  • 抗β2-グリコプロテインI抗体の反応特異性の解析:酸性リン脂質由来の脂肪酸の関与

    小林 和子, 松浦 栄次, 稲垣 純子, 貝原 恵子, 保田 立二, 小池 隆夫

    日本臨床免疫学会会誌 ( 26回抄録集 ) 242 - 242   1998年10月

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    記述言語:日本語   出版者・発行元:日本臨床免疫学会  

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  • 自己抗原であるβ2-グリコプロテインIの三次構造

    山本 大助, 松浦 栄次, 貝原 恵子, 稲垣 純子, 小林 和子, 保田 立二, 小池 隆夫

    日本臨床免疫学会会誌 ( 26回抄録集 ) 239 - 239   1998年10月

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    記述言語:日本語   出版者・発行元:日本臨床免疫学会  

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  • 自己抗原であるβ2-グリコプロテインIの不活化:plasminによる酵素的開裂に伴う抗原性の消失

    松浦 栄次, 稲垣 純子, 小林 和子, 貝原 恵子, 保田 立二, 山本 大助, 笠原 英樹, 市川 健司, 堤 明人, 小池 隆夫

    日本臨床免疫学会会誌 ( 26回抄録集 ) 242 - 242   1998年10月

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    記述言語:日本語   出版者・発行元:日本臨床免疫学会  

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  • Identification of the epitopes of anticardiolipin antibodies on the tertial structure of beta 2-glycoprotein I.

    K Ichikawa, H Kasahara, E Matsuura, D Yamamoto, A Tsutsumi, H Kitakawa, T Atsumi, T Koike

    ARTHRITIS AND RHEUMATISM41 ( 9 ) S135 - S135   1998年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Detection of peptides recognized by anticardiolipin antibodies using phage displayed random peptide library.

    H Kasahara, K Ichikawa, A Tsutsumi, E Matsuura, S Kobayashi, T Koike

    ARTHRITIS AND RHEUMATISM40 ( 9 ) 430 - 430   1997年9月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:LIPPINCOTT-RAVEN PUBL  

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  • Anti-beta 2-glycoprotein I antibody and lupus anticoagulant in patients with recurrent pregnancy loss

    M Ogasawara, T Aoyama, K Katano, E Matsuura, K Aoki

    THROMBOSIS AND HAEMOSTASIS   P1345 - P1345   1997年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN  

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  • Anti-beta 2-glycoprotein I monoclonal antibodies with lupus anticoagulant-like activity enhance the beta 2GPI binding to phospholipids

    H Takeya, EC Gabazza, E Matsuura, T Koike, K Suzuki

    THROMBOSIS AND HAEMOSTASIS   OC687 - OC687   1997年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN  

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  • Inhibitory effect of beta 2-glycoprotein I on the anticoagulant activity of activated protein C, and its modulation by anti-beta 2-glycoprotein I monoclonal antibodies

    H Urano, H Takeya, T Mori, EC Gabazza, E Matsuura, T Koike, K Suzuki

    THROMBOSIS AND HAEMOSTASIS   P2199 - P2199   1997年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN  

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  • COFACTOR (BETA(2)-GLYCOPROTEIN-1) DEPENDENT ANTICARDIOLIPIN ANTIBODIES AND THROMBOSIS

    J KABURAKI, M KUWANA, Y IKEDA, M YAMAMOTO, S KAWAI, E MATSUURA

    JOURNAL OF RHEUMATOLOGY21 ( 7 ) 1371 - 1371   1994年7月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:J RHEUMATOL PUBL CO  

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  • BINDING OF BETA-2-GLYCOPROTEIN-I TO PLATELET-DERIVED MICROPARTICLES

    S NOMURA, Y KOMIYAMA, E MATSUURA, T KOKAWA, H TAKAHASHI, T KOIKE

    BRITISH JOURNAL OF HAEMATOLOGY85 ( 3 ) 639 - 639   1993年11月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:BLACKWELL SCIENCE LTD  

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  • ANTICARDIOLIPIN ANTIBODIES RECOGNIZE AN ALTERED BETA-2-GLYCOPROTEIN-I STRUCTURE

    E MATSUURA, Y IGARASHI, H NAGAE, M IGARASHI, T KOIKE

    THROMBOSIS AND HAEMOSTASIS69 ( 6 ) 1012 - 1012   1993年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:F K SCHATTAUER VERLAG GMBH  

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  • SPECIFICITY AND CLINICAL-SIGNIFICANCE OF ANTICARDIOLIPIN AUTOANTIBODIES DETECTED BY AN IMPROVED ELISA SYSTEM USING THE COMPLEX OF CARDIOLIPIN AND A COFACTOR

    T KOIKE, T SUZUKI, K ICHIKAWA, M FUJIMOTO, Y IGARASHI, E MATSUURA

    THROMBOSIS AND HAEMOSTASIS65 ( 6 ) 1256 - 1256   1991年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:F K SCHATTAUER VERLAG GMBH  

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  • CHARACTERIZATION OF THE ANTICARDIOLIPIN COFACTOR AND A PRECISE ASSAY SYSTEM FOR ANTICARDIOLIPIN ANTIBODIES IN PATIENTS WITH AUTOIMMUNE-DISEASES

    E MATSUURA, Y IGARASHI, M FUJIMOTO, K ICHIKAWA, T SUZUKI, T KOIKE

    THROMBOSIS AND HAEMOSTASIS65 ( 6 ) 848 - 848   1991年6月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:F K SCHATTAUER VERLAG GMBH  

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  • EFFECT OF IMMUNOREGULATORY ALPHA-GLOBULIN (IRA) ON EXPERIMENTAL ARTHRITIS IN RATS

    E MATSUURA, M TSUCHIMOTO, C YAMAGUCHI, T SUEYOSHI, YAMAMOTO, I

    FOLIA PHARMACOLOGICA JAPONICA85 ( 5 ) P57 - P58   1985年

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    記述言語:日本語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:JAPANESE PHARMACOLOGICAL SOC  

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  • DEFICIENCY OF PLASMA IMMUNOSUPPRESSIVE ALPHA-GLOBULINS IN SPONTANEOUSLY HYPERTENSIVE RATS

    E MATSUURA, T SUEYOSHI, YAMAMOTO, I

    CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE7 ( 12 ) 1772 - 1772   1985年

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MARCEL DEKKER INC  

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▼全件表示

講演・口頭発表等

  • A novel single chain valiant of antibody (scFv) against mesothelin (MSLN) established by phage library for PET imaging

    Matsuura E, Yakushiji H, Kobayash K, Takenaka F, Akehi M, Sasaki T

    World Mol Imaging Conference, Seattle, USA  2018年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • roteolysis-resistant domains in β2-glycoprotein I (β2GPI): Features and potent applications in lipidomics 招待

    Matsuura E

    nternational Congress on Autoimmunity, Lisbon, Portugal  2018年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Autoimmunity and angiogenesis 招待

    Matsuura E

    International Congress on Autoimmunity, Lisbon, Portugal  2018年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • New era of in vivo molecular imaging and targeted medical care: Antibody-based theranostics 招待

    Matsuura E

    NewYork Pharma Forum (NYPF) , New York、USA  2018年3月 

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    記述言語:英語  

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  • Theranostics: A holistic and revolutionized regime in cardiovascular medicine 招待

    Matsuura E

    Joint Meeting of Coronary Revascularization Convenes in Busan. Busan, South Korea  2017年12月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Theranostics: The modern revolution and future of cancer medicine and oncological management 招待

    Matsuura E

    Scholar Summit 2017. Depok, Indonesia  2017年10月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • A holistic and revolutionized regime in cardiovascular medicine 招待

    Matsuura E

    International Conference on Advance Pharmacy and Pharmaceutical Sciences (ICAPPS)  2017年10月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Harnessing disease-specific antibodies and its variant in theranostics 招待

    Matsuura E

    oint meeting of Australia’s MedTech Conference and International Conference on Mechanics in Medicine and Biology (ICMMB), Melbourne, Australia,  2017年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Harnessing autoimmunity (disease-specific autoantibodies and its variant) in theranostics of disease 招待

    Matsuura E

    Joint meeting of Lupus and Asian Congress on Autoimmunity, Melbourne, Australia  2017年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Natural ameliorative biomaterial for oxidative stress and inflammation

    Tan XW, Wang SS, Matsuura E

    Joint meeting of Australia’s MedTech Conference and International Conference on Mechanics in Medicine and Biology (ICMMB), Melbourne, Australia  2017年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Evaluation of whole-body biodistribution of 89Zr-labeled antibodies in cynomolgus macaque with PET

    Sasaki T, Kimura S, Noda A, Murakami Y, Takenaka F, Miyoshi S, Matsuura E

    Annual Meeting of the European Association of Nuclear Medicine, Barcelona, Spain,  2016年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Okayama Medical Innovation Center (OMIC) and molecular imaging 招待

    Matsuura E

    The 1st Asian Researcher Symposium 2016. Depok, Indonesia  2016年8月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Intensive Scientific Writing Coaching Clinic. 招待

    Matsuura E

    2016年8月 

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    記述言語:英語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • Immuno-thera-diagnostics (theranostics) in autoimmunity and oncology 招待

    Matsuura, E

    International Congress on Autoimmunity, Leipzig, Germany  2016年4月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Narcolepsy as an autoimmune disease

    Arango M, Kivity S, Sasaki T, Blank M, Matsuura E, Shoenfeld Y

    International Congress on Autoimmunity, Leipzig, Germany  2016年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • The role of lipoprotein oxidative inflammation and β2-glycoprotein I in innate immunity of early atherosclerosis 招待

    Matsuura E

    International Congress on Autoimmunity, Leipzig, Germany,  2016年4月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Okayama Medical Innovation Center (OMIC) and molecular targeting technology 招待

    Matsuura, E

    International Symposium on Bio-imaging and Gene Targeting Sciences in Okayama. Okayama, Japan  2015年2月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Okayama Medical Innovation Center (OMIC) and a novel molecular targeting technology 招待

    Matsuura E

    National Conference for Clinical Research 2014, Kuching, Malaysia  2014年10月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Elucidation of the pharmacokinetic difference of regioisomeric retinoid X receptor agonists having an alkoxy group by PET imaging

    Kobayashi T, Kawata K, Nakayama M, Furusawa Y, Yamada S, Hirano H, Takenaka F, Akehi M, Sasaki T, Matsuura E, Tai A, Kakuta H

    National Meeting of the American Chemical Society (ACS), San Francisco, USA  2014年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Circulating pro-atherogenic oxidized LDL/β2-glycoprotein I complexes are detected in arterial and venous diseases and are independent predictors of carotid arterial disease

    Lopez LR, Matsuura E, Guyer KE, Rockman CB, Berger JS

    Congress of the European Atherosclerosis Society, Madrid, Spain  2014年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Significant accumulation of oxLDL/β2-glycoprotein I complexes in arterial lesions of WHHL rabits: PET/CT imaging using an autoantibody’s scFv variant

    Sasaki T, Matsunami Y, Takanaka F, Kita S, Hirano H, Shen L, Kobayashi K, Matsuura E, Guyer KE, Rockman CB, Berger JS

    Congress of the European Atherosclerosis Society, Madrid, Spain  2014年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Autoimmune and infection-mediated atherosclerosis: possible mechanisms and innovation from translational biomedical researches 招待

    Matsuura E

    International Congress on Autoimmunity, Nice, France  2014年3月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Immunogenic oxidized low-density lipoprotein/β2-glycoprotein I (oxLDL/β2GPI) complexes in atherothrombotic cardiovascular diseases: clinical determinants and significance

    Berger JS, Guyer K, Rockman CB, Matsuura E, Lopez LR

    International Congress on Autoimmunity, Nice, France  2014年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • In vivo molecular imaging using humanized anti-β2-glycoprotein I autoantibodies to detect arterial lesions in the atherosclerosis-prone ApoE-/- mice

    Matsunami Y, Sasaki T, Takenaka F, Kobayashi K, Kita S, Kojima K, Matsuura E

    International Congress on Autoimmunity, Nice, France  2014年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidized lipids composed of atherogenic complex autoantigen: by liposome analyses with cutting-edge imaging mass microscope (IMscope)

    Shen L, Arum Tri W, Kobayashi K, Yamamoto T, Ogata K, Ando E, Ozeki E, Matsuura E

    International Congress on Autoimmunity, Nice, France  2014年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Recombinant domain V of β2-glycoprotein I inhibits the formation of atherogenic oxLDL/β2-glycoprotein I complexes

    Liu Q, Chi Y, Li J, Wang R, Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Infection and immunity-mediated atherosclerosis 招待

    Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Autoantibodies against β2-glycoprotein I really atherogenic?: Answers from in vivo PET imaging studies in apolipoprotein E-deficient mice

    Matsunami, Y, Sasaki T, Takenaka F, Kobayashi K, Kojima K, Kita S, Hirano H, Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • A non-invasive PET/CT imaging procedure for diagnosing atherosclerotic lesions: immunologic targeting to oxLDL/β2-glycoprotein I in the WHHL rabbits

    Sasaki T, Matsunami Y, Takenaka F, Hirano F, Kita S, Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • etection of oxidized lipoproteins accumulated in atherosclerosis lesions byimaging mass microscopy (iMS)

    Shen L, Arum Tri Wahyuningsih, Kobayashi K, Sasaki T, Matsunami Y, Takenaka F, Ando E, Yamamoto T, Ogata K, Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Pathological implication of autoantibodies against β2-glycoprotein I and a novel “Immuno-TheranoDiagnostics” in atherosclerosis 招待

    Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Lipoprotein/β2-Glycoprotein I (oxLDL/β2GPI) complexes in atherothrombotic cardiovascular diseases

    Lopez LR, Guyer K, Matsuura E, Rockman CB, Berger JS

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Autoimmunity accelerates atherogenesis: oxidized-LDL/β2-glycoprotein I complexes and anti-β2-glycoprotein I antibodies enhance the risk of cardiovascular events in acute coronary syndrome

    Lopez LR, Greco TP, Hurley B, Boisen M, Matsuura E

    Autoimmune Congress Asia, Hong Kong  2013年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Autoimmunity, oxidative inflammation, and β2-glycoprotein I in early atherogenesis 招待

    Matsuura E

    Controversies and Rheumatology & Autoimmunity 2013. Budapest, Hungary  2013年4月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Pathophysiology of atherosclerosis: acceleration by inflammation and immunity 招待

    Matsuuura E

    International Conference “Bioactive Okayama 2012, Okayama, Japan  2012年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • β2-Glycoprptein I and oxidative inflammation in atherogenesis of autoimmune atherothrombotic diseases 招待

    Matsuura E

    International Congress on Autoimmunity, Granada, Spain  2012年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Aspirin inhibition of thromboxane does not affect oxidative stress, nitric oxide matabolites, paraoxonase activity or P-selectin levels in diabetes

    Lopez LR, Batuca JR, Muncy IJ, De La Torre, IG Matsuura E, Ames PRJ

    European Association for Study of Diabetes (EASD 2011) Annual Meeting, Lisbon, Portugal  2011年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-atherogenic plaque reduction, inhibition of oxLDL/β2GPI autoantigen and thromboxane platelet activation by persimmon (Diospyros kaki) peel in LDLR-/--deficient mice

    Matsuura E, Quan N, Kobayashi K, Matsunami Y, Ide M, Makarova M, Shen L, Ohno S, Zheng Y, Kobayashi H, Lopez LR

    Congress of the International Society on Thrombosis and Haemostasis (ISTH 2011), Kyoto, Japan  2011年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Rosuvasutatin decreases serum levels of oxidized low-density lipoprotein/β2-glycoprotein I complex through the nitric oxide pathway in diabetes mellitus

    Lopez LR, Muncy I, Matsuura E, Batuca J, Garcia-De La Torre I, Ames PRJ

    Congress of the International Society on Thrombosis and Haemostasis (ISTH 2011), Kyoto, Japan  2011年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Distinctive aspirin effect on the arachidonic acid pathway, oxidative stress, Nitric oxide metabolites and P-selectin in diabetes mellitus

    Lopez LR, Muncy I, Matsuura E, Batuca J, Guyer K, Garcia-De La Torre I, Ames PRJ

    Congress of the International Society on Thrombosis and Haemostasis (ISTH 2011), Kyoto, Japan  2011年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Simultaneous occurrence of natural immunity, atherogenic in vivo LDL oxidation and thromboxane-mediated platelet activation in atherosclerosis-prone (LDLR+/- apoE+/-) mice

    Matsuura E, Shen L, Matsunami Y, Quan N, Kobayashi K, Shoenfeld Y, Oguma K, Lopez LR

    Congress of the International Society on Thrombosis and Haemostasis (ISTH 2011), Kyoto, Japan  2011年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-atherogenic effects of Persimmon (Diospyros Kaki) peel in LDLR-/--deficient mice. Plaque reduction, inhibition of oxLDL/β2GPI autoantigeni and thromboxane platelet activation

    Matsuura E, Quan N, Kobayashi K, Matsunami Y, Ide M, Makarova M, Shen L, Ohno S, Zheng Y, Kobayashi H, Lopez LR

    European Atherosclerosis Society Congress (EAS 2011), Gothenburg, Sweden  2011年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Differential effect of aspirin on oxidative stress, thromboxane, nitric oxide metabolites and P-selectin in type 2 diabetes mellitus

    Lopez LR, Muncy I, Matsuura E, Batuca J, Oregon-Miranda A, Garcia De, La Torre I, Ames PR

    European Atherosclerosis Society Congress (EAS 2011), Gothenburg, Sweden  2011年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Atherogenic in vivo oxidation, thromboxane-mediated platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone (LDLR-/- and ApoE-/-) mice

    Matsuura E, Shen L, Matsunami Y, Quan N, Kobayashi K, Shoenfeld Y, Oguma K, Lopez LR

    European Atherosclerosis Society Congress (EAS 2011), Gothenburg, Sweden  2011年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Atherogenic oxLDL/β2GPI and nitric oxide metabolites in type 2 diabetes: baseline relationships and effect of rosuvastatin treatment

    Ames PRJ, Garcia-De La Torre I, Batuca J, Ortiz-Cadenas A, Oregon-Miranda A, Kojima K, Matsuura E, Lopez LR

    International Congress on Autoimmunity, Ljubljana, Slovenia  2011年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Accelerated Atherosclerosis in APS 招待

    Matsuura E

    International Congress on APL antibodies, Galveston, Texas, USA  2010年8月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Oxidized-LDL/β2-glycoprotein I complexes and antiphospholipid antibodies are associated with disease severity and risk for adverse outcomes in acute coronary syndrome

    Lopez LR, Greco TP, Conti-Kelly AM, Anthony JR, Doyle R, Geske FJ, Boisen M, Matsuura E

    European Atherosclerosis Society Congress, Hamburg, Germany  2010年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Rosuvastatin promotes antioxidant effect through nitric oxide pathway and reduces serum levels of oxidized-LDL/β2GPI complexes in patients with diabetes mellitus

    Lopez LR, Ames PRJ, Batuca J, Garcia-De La Torre I, Kojima K, Matsuura E

    European Atherosclerosis Society Congress, Hamburg, Germany  2010年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Co-presence of oxidized-LDL/β2-glycoprotein I complexes and antiphospholipid antibodies enhances the risk of adverse cardiovascular events

    Lopez LR, Greco TP, Conti-Kelly AM, Anthony R, Greco T Jr, Boisen M, Kojima K, Matsuura E

    International Congress on Autoimmunity, Ljubljana, Slovenia  2010年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Pathophysiological roles of β2-glycoprotein (β2GPI) and anti-β2GPI antibodies 招待

    Matsuura E

    International Congress on Autoimmunity, Ljubljana, Slovenia  2010年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Effect of bacterial heat shock protein 60 on immunological reactions in Behcet’s disease and in mouse model for atherosclerosis

    Oguma K, Yokota K, Lianhua S, Kaneko F, Isogai E, Matsuura E

    International Congress on Autoimmunity, Ljubljana, Slovenia  2010年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • The role of oxidized LDL/β2GPI complexes and anti-β2GPI antibodies in autoimmune-mediated atherosclerosis

    Lopez LR, Greco T, Conti-Kelly AM, Anthony R, Boisen M, Kojima K, Matsuura E

    International Congress on APL antibodies, Galveston, Texas, USA  2010年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • The role of oxidized LDL/β2GPI complexes and anti-β2GPI antibodies in autoimmune-mediated atherosclerosis. Atherogenic oxLDL/β2GPI complexes and nitric oxide metabolites in type 2 DM: baseline relationships and effect of Rosuvastatin treatment

    Ames PRJ, Garcia-De La Torre I, Batuca J, Kojima K, Matsuura E, Lopez LR

    International Congress on APL antibodies, Galveston, Texas, USA  2010年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 自己免疫・感染免疫が惹起する動脈血栓 招待

    松浦栄次

    岡山研究皮膚科フォーラム  2010年1月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • APL antibodies (anti-β2GPI and anti-oxLDL/β2GPI) predict adverse outcomes in patients with acute coronary syndromes

    Greco T, Conti-Kelly AM, Doyle R, Greco T Jr, Matsuura E, Anthony R, Lopez LR

    International Congress on Coronary Artery Disease, Prague, Czech Republic  2009年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Elevated serum levels of oxidized LDL/β2GPI complexes increase the risk for cardiovascular adverse outcomes in patients with acute coronary syndromes

    Lopez LR, Conti-Kelly AM, Doyle R, Kojima K, Matsuura E, Anthony R, Greco T

    International Congress on Coronary Artery Disease, Prague, Czech Republic  2009年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Rosuvastatin reduces serum levels of oxidized LDL/β2GPI complexes in patients with type 2 DM

    Lopez LR, Ortiz-Cadenas A, Garcia-De La Torre I, Nava A, Oregon-Miranda A, Kojima K, Matsuura E

    International Congress on Coronary Artery Disease, Prague, Czech Republic  2009年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Atherogenesis an angiogenesis in autoimmunity 招待

    Matsuura E

    Asian Congress on Autoimmunity. Singapore  2009年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Immunity in infection-triggered atherosclerosis 招待

    Matsuura E

    The 6th International Congress on Autoimmunity  2008年9月 

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  • Antiphospholipid antibodies predict adverse outcomes in patients with acute coronary syndrome

    Greco T, Conti-Kelly AM, Doyle R, Matsuura E, Lopez LR

    The 6 th International Congress on Autoimmunity  2008年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidized low-density lipoprotein I and β2-glycoprotrein I in patients with systemic lupus erythematosus: implications in autoimmune-mediated atherosclerosis

    Lopez LR, Salazar-Paramo M, Palafox-Sanchez C, Matsuura E, Garcia De La Torre I

    The 6 th International Congress on Autoimmunity  2008年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Atherothrombosis in autoimmunity 招待

    Matsuura E

    The 6th International Congress on Autoimmunity  2008年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Recent progress in understanding on immune- and infection-mediated atherosclerosis and cardiovascular disease 招待

    Matsuura E

    The 2nd Moscow International Conference“Immunophysiology: Natural Autoimmunity in Pysiology and Pathology  2008年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • An abnormal lipid profile in primary antiphospholipid syndrome relates to oxidized low-density lipoprotein bound to β2-glycoprotein I

    Ames A, Batuca J, Foglia M, Delgado Alves J, Ciampa A, Antinolfi I, Lopez LR, Matsuura E

    The 6th International Congress on Autoimmunity  2008年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Antiphospholipid Syndrome and pro-atherogenic oxidized low-density lipoprotein β2-glycoprotein I complexes 招待

    Matsuura E

    International Conference on Cutaneous Lupus Erythematosus, Kyoto, Japan  2008年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Low grade inflammation and in vivo immune activation in primary antiphospholipid syndrome

    Ames PR, Ciampa A, Matsuura E, Lopez LR, Scenna G, Antinolfi I, Iannaccone L, Ferrara F

    Annual Meeting of the British Society Rheumatology/Spring Meeting of British Professonal Rheumatology, Liverpool, UK  2008年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 自己免疫・感染免疫が惹起する動脈硬化 招待

    松浦栄次

    第12回九州セロトニン研究会  2008年3月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Preventing autoimmune and infection triggered atherosclerosis for an enduring healthful lifestyle

    The Mosaic of Autoimmunity An International Satellite of the Congress on Autoimmunity  2008年 

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  • Are Antiphospholipid Antibodies Risk Factors for Coronary Artery Disease?

    Greco TP, Conti-Kelly AM, Matsuura E, Greco T Jr, Dier KJ, Svanas G, Doyle R, Lopez LR

    International Society on Thrombosis and Haemostasis, Geneva, Switzerland  2007年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Reduction of diabetes-related lipid oxidative stress by statin therapy as monitored by serum oxidized LDL/β2GPI complex levels

    Svanas G, Boisen M, Oottamasathein D, Matsuura E, Lopez LR

    International Society on Thrombosis and Haemostasis, Geneva, Switzerland  2007年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Association of IgG anti-oxLDL/β2GPI and 2GPI-dependent anti-cardiolipin (aCL) antibodies with vascular thrombosis in patients with antiphospholipid syndrome (APS)

    Svanas G, Boisen M, Oottamasathein D, Matsuura E, Lopez LR

    International Society on Thrombosis and Haemostasis, Geneva, Switzerland  2007年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 自己免疫・感染免疫と動脈硬化 招待

    松浦栄次

    第30回日本基礎老化学会・シンポジウム  2007年6月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Clinical significance of antiphospholipid antibodies and autoimmune-accelerated atherosclerosis 招待

    Matsuura E

    The 2007 Changsha International Symposium on Lupus. Changsha, China  2007年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Infection and atherosclerosis 招待

    Matsuura E

    International Congress on SLE. Shanghai, China  2007年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Accelerated atherosclerosis in autoimmune rheumatic diseases.

    Shoenfeld Y, Gerli R, Doria A, Matsuura E, Cerinic MM, Ronda N, Jara LJ, Abu-Shakra M, Meroni PL, Sherer Y

    5th International Congress on Autoimmunity  2006年12月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Antiphospholipid antibodies involved in atherosclerosis in APS.

    Kobayashi K, de Groot PG, Matsuura E

    5th International Congress on Autoimmunity  2006年12月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • ntiphospholipid and anti-oxidized LDL antibodies in patients with undergoing coronary artery angiography

    Greco TP, Conti-Kelly AM, Greco, TP Jr, Dier K, Matsuura E, Lopez LR

    International Congress on Autoimmunity, Sorrento, Italy,  2006年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Excessive exposure to anionic surfaces maintains autoimmune response to β2-glycoprotein I in patients with antiphospholipid syndrome

    Yamaguchi Y, Seta N, Okazaki Y, Kaburaki J, Matsuura E, Kuwana M

    American College of Rheumatology (ACR) Meeting Washington DC, USA  2006年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • ew aspects on autoimmunity, infection, and atherosclerosis 招待

    Matsuura E, Shoenfeld Y

    International Congress on Autoimmunity. Sorrento, Italy  2006年11月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Elicited Th1 immune response to Helicobacter pylori promotes atherosclerosis in mice.

    Ayada K, Yokota K, Kobayashi K, Okada T, Yoshino T, Shoenfeld Y, Matsuura E, Oguma K

    5th International Congress on Autoimmunity  2006年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Atherosclerosis in primary antiphospholipid syndrome

    Ames PRJ, Lopez LR, Margarita A, Scenna G, Matsuura E, Ciampa A, Brancaccio V

    International Congress on Autoimmunity, Sorrento, Italy  2006年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Determination of oxidized-LDL versus oxidized-LDL/β2GPI complexes for the assessment of autoimmune-mediated atherosclerosis. Atherosclerosis in primary antiphospholipid syndrome

    Lopez LR, Hurley BL, Kobayashi K, Matsuura E

    International Congress on Autoimmunity, Sorrento, Italy  2006年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 自己免疫・感染免疫と動脈硬化 招待

    松浦栄次

    Helicobacter pyloriフォーラム  2006年9月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Atherosclerosis in primary antiphospholipid syndrome.

    Ames PRJ, Margarita A, Scenna G, Lopez LR, Matsuura E, Ciampa A, Brancaccio V

    5th International Congress on Autoimmunity  2006年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Measurement of oxidized low-density lipoproteins (oxLDL) and oxLDL/β2GPI complexes by ELISA for the assessment of autoimmune-mediated atherosclerosis

    Lopez LR, Hurley BL, Matsuura E

    Congress of the Pan American League of Associations for Rheumatism, Lima, Peru  2006年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Autoimmune-mediated atherosclerosis: Carotid intima-media thickness and oxidized low-density lipoproteins in SLE

    Palofox-Sanchez C, Salazar-Paramo M, Lopez LR, Matsuura E, Garcia de, la Torre I

    Congress of the Pan American League of Associations for Rheumatism, Lima, Peru  2006年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Update “Autoimmunity and atherosclerosis" 招待

    Matsuura E

    Methodist Hospital Special Lecture. Indianapolis, USA  2006年6月 

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    記述言語:英語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • 酸化LDL・2-glycoprotein Iと動脈硬化性疾患 招待

    松浦栄次

    第13回自己抗体と自己免疫シンポジウム「臓器特異的自己抗体 ―新たな展開―」  2006年1月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Clinical significance of natural and autoantibodies against oxidized low-density lipoprotein (oxLDL) and its complexes with β2-glycoprotein I. 招待

    Matsuura E

    1st Moscow International Working Conference "Natural Autoimmunity in Physiology and Pathology,  2005年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Autoantibodies to oxLDL/β2GPI complexes and autoimmune-mediated athero-thrombotic disease in patients with systemic autoimmune disorders and antiphospholipid syndrome 招待

    Matsuura E, Lopez LR

    Scientific Subcommittees of the Scientific and Standardization Committee. International Society on Thrombosis and Haemostasis, Sydney, Australia  2005年7月 

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  • Basic and clinical aspects on oxidized LDL complexes with 2-glycoprotein I and CRP 招待

    Matsuura E

    Conference on Heart, Rheumatism, and Autoimmunity, Pescara, Italy  2005年5月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Clinical significance of protein-oxLDL complexes and related autoantibodies. 招待

    Matsuura E

    2nd Tutzing Antiphospholipid Conference.  2005年4月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Pro-atherogenic role for IgG anti-oxidized low-density lipoprotein-β2-glycoprotein I complex in primary antiphospholipid syndrome

    Ames PRJ, Delgado Alves J, Lopez LR, Iannaccone L, Margarita A, Scenna G, Brancaccio V, Matsuura E

    International Congress on Autoimmunity, Budapest, Hungary  2004年11月 

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  • IgG antibodies to oxLDL/β2GPI complexes are associated with arterial thrombosis in patients with antiphospholipid syndrome

    Lopez LR, Kuca J, Hurley B, Andrews J, Fink C, Merrill JT, Matsuura E

    4th International Congress on Autoimmunity  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Role of natural antibodies and autoantibodies on development of atherosclerosis

    Matsuura E, Kobayashi K, Shoenfeld Y, Lopez LR

    4th International Congress on Autoimmunity  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • IgG and IgM anti-oxLDL/β2GPI antibodies in patients with autoimmune disorders and antiphospholipid syndrome

    Lopez LR, Kuca J, Hurley B, Fink C, Matsuura E

    4th International Congress on Autoimmunity  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • IgG anti-oxLDL/β2GPI antibodies in the antiphospholipid syndrome: association with arterial thrombosis

    Lopez LR, Dier K, Andrews J, Fink C, Merrill, JT, Matsuura E

    11th International Congress on Antiphosphoipid Antibodies  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • T lymphocyte subsets in primary antiphospholipid syndrome.

    Ames PRJ, Tommasino C, Fossati G, Lopez LR, Matsuura E, Margarita A, Scenna G, Brancaccio V

    11th International Congress on Antiphosphoipid Antibodies  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Reduced concentration of β2GPI in RA and aPL positive patients - a probable marker of accelerated atherosclerosis?

    Ambrozic A, Pahor V, Rozman B, Tomsic M, Kveder T, Kobayashi K, Matsuura E

    4th International Congress on Autoimmunity  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-laminin-1 autoantibodies, pregnancy loss and endometriosis

    Inagaki J, Kondo A, Lopez LR, Shoenfeld Y, Matsuura E

    4th International Congress on Autoimmunity  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • OxLDL/β2GPI complexes in patients with systemic lupus erythematosusu and systemic sclerosis: pathogenic implications for vascular involvement

    Lopez LR, Hurley B, Dier K, Fink C, Matsuura E

    International Congress on Autoimmunity, Budapest, Hungary  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • The relationship of oxLDL, β2GPI and β2GPI-oxLDL complexes in patients with APS

    Ambrozic A, Kveder T, Rosman B, Matsuura E

    11th International Congress on Antiphosphoipid Antibodies  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Circulation oxLDL/β2GPI complexes in autoimmune disease: pathogenic implications for systemic lupus erythematosus and systemic sclerosis

    Lopez LR, Dier K, Hurley B, Kuca J, Fink C, Matsuura E

    11th International Congress on Antiphosphoipid Antibodies  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • OxLDL/β2GPI complexes in type II diabetes mellitus

    Lopez LR, Hurley B, Kuca J, Dier K, Fink C, Matsuura E

    11th International Congress on Antiphosphoipid Antibodies  2004年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Thrombogenic autoantigen in APS 招待

    Matsuura E

    9th International Congress of Reproductive Immunology  2004年10月 

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  • icked β2-glycoprotein I binds plasminogen and play a role in extrinsic fibrinolysis via negative feedback mechanism

    Yasuda S, Atsumi T, Ieko M, Matsuura E, Amasaki Y, Koike T

    American College of Rheumatology (ACR) Meeting, San Antonio, USA  2004年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-laminin-1 autoantibodies in endometriosis

    Inagaki J, Nakatsuka M, Nomizu M, Aoki K, Matsuura E

    9th International Congress of Reproductive Immunology  2004年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-laminin-1 autoantibodies in reproductive failure: human and animal studies 招待

    Matsuura E

    Dresden Symposium on Autoantibodies. Dresden, Germany  2004年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Atherogenic role of protein modified oxidized low-density lipoproteins and their autoantibodies 招待

    Matsuura E

    7th Dresden Symposium on Autoantibodies  2004年9月 

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  • 抗リン脂質抗体と酸化LDL 招待

    松浦栄次

    臨床化学会夏期セミナー(シンポジウム)  2004年8月 

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    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • Oxidized low-density lipoprotein complexed with β2-glycoprotein I: a common metabolic form and a possible thrombogenic autoantigen

    Matsuura E, Kobayashi K, Yasuda T, Makino H, Lopez LR

    12th International Congress of Immunology  2004年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Hybridomas expressing γδT cell receptor respond to cardiolipin and β2-glycoprotein I (apolipoprotein H)

    Born W, Vollmer M, Readon C, Matsuura E, Voelker DR

    International Congress of Immunology, Montreal, Canada  2004年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Autoantibodies to β2GPI/oxLDL complexes: a novel risk factor for thromboembolic disease in SLE?

    Lopez LR, Garcia De, La Torre I, Matsuura E

    Int Congress on Thrombosis. Ljubljana, Slovenia  2004年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Carboxyl variants of cholesteryl-linoleate as a ligand for β2-GPI and a possible mechanism on autoantibody mediated atherosclerosis 招待

    Matsuura E

    Tutzing Antiphospholipid Conference. Tutzing, Germany  2004年4月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Binding of β2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells.

    Kuwana M, Okazaki Y, Kaburaki J, Kawakami Y, Matsuura E

    American College of Rheumatology  2003年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-idiotypes against oxidized LDL antibodies intravenous immunoglobulin preparations explanation for its immunomolulatory effects in atherosclerosis

    Sherer Y, Wu R, Matsuura E, Gilburd B, Koike T, Peter JB, Shoenfeld Y

    Annual European Congress of Rheumatology, Lisbon, Portugal  2003年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • IgG autoantibodies to oxLig-1/β2GPI complex are associated with arterial thrombosis in patients with antiphospholipid syndrome

    Lopez D, Merrill JT, Matsuura E, Lopez LR

    Congress of the International Society on Thrombosis and Haemostasis  2003年7月 

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  • Detection and clinical significance of oxidized LDL complexes with β2-glycoprotein I and/or C-reactive protein

    Kobayashi, K, Kishi M, Atsumi T, Bertolaccini ML, Kasahara J, Makino H, Sakairi N, Yamamoto I, Yasuda T, Khamashta MA, Hughes GRV, Koike T, Voelker DR, Matsuura E

    Atherosclerosis, Gordon Research Conference  2003年6月 

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    記述言語:英語   会議種別:シンポジウム・ワークショップ パネル(公募)  

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  • OxLDL/β2GPI complexes are frequent in SLE whereas autoantibodies to oxLig-1/β2GPI are more prevalent in patients with antiphospholipid syndrome

    Lopez D, Garcia-Valladares I, Palafox-Sanchez C, Matsuura E, De La Torre IG, Lopez LR

    Congress of the International Society on Thrombosis and Haemostasis, Birmingham, UK  2003年6月 

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  • 酸化LDL研究の現状と将来.概論・臨床面・近年の動向 招待

    松浦栄次

    第13回日本生物試料分析学会総会・シンポジウム  2003年3月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Increased levels of oxidized-LDL and autoantibodies to oxLig-1/β2GPI Complex in systemic lupus erythematosus

    Matalon ST, Blank M, Matsuura E, Inagaki J, Nomizu M, Koike T, Sherer Y, Ornoy A, Lopez LR, Lopez D, Dier KJ, Fink CA, Kobayashi K, Matsuura E

    American College of Rheumatology Annual Scientific Meeting, New Orleans, USA  2002年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Determination and significance of Autoantibodies to oxLig-1/β2GPI complex in patients with APS.

    Lopez D, Garcia-Valladares I, Dier K, Fink C, Kobayashi K, Matsuura E, Lopez LR

    10th International Congress on Antiphospholipid Antibodies  2002年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidized LDL, not anti-oxidized LDL, predicts coronary calcification

    Petri M, Shoenfeld Y, Matsuura E

    American College of Rheumatology Annual Scientific Meeting, New Orleans, USA  2002年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Antigenic levels and autoantibodies to oxidized-LDL in patients with antiphospholipid syndrome

    Lopez D, Dier JK, Fink CA, Lopez LR, Merrill JT, Matsuura E

    American College of Rheumatology Annual Scientific Meeting, New Orleans, USA  2002年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Increased levels of oxidized-LDL in SLE: detection by ELISA using an anti-β2GP1 monoclonal antibody

    Lopez D, Dier K, Fink C, Kobayashi K, Matsuura E, Lopez LR

    International Congress on Antiphospholipid Antibodies, Taormina, Italy  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Induction of reproductive failure by active immunization with laminin-1.

    Matalon ST, Blank M, Matsuura E, Inagaki J, Nomizu M, Koike T, Sherer Y, Ornoy A, Shoenfeld Y

    10th International Congress on Antiphospholipid Antibodies  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Clinical association of IgG anti-laminin-1 autoantibodies with reproductive failure.

    Inagaki J, Aoki K, Koike T, Shoenfeld Y, Matsuura E

    10th International Congress on Antiphospholipid Antibodies  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Pregnancy outcome: Association with anti-laminin-1 antibodies in human and in immunized mice.

    Kondo A, Tartakover-Matalon S, Blank M, Inagaki J, Kobayashi K, Yasuda T, Aoki K, Koike T, Makino T, Shoenfeld Y, Matsuura E

    10th International Congress on Antiphospholipid Antibodies  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • A novel ELISA for oxidized LDL, utilizing an interaction among oxidized LDL, β2-glycoprotein I, and anti-β2-glycoprotein I autoantibody

    Kobayashi K, Kishi M, Lopez D, Liu Q, Yasuda T, Koike T, Lopez LR, Matsuura E

    nternational Congress on Antiphospholipid Antibodies, Taormina, Italy  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidized LDL as a risk of thrombosis in APS 招待

    Matsuura E

    International Congress on Antiphospholipid Antibodies. Taormina, Italy  2002年9月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Update “Autoimmunity and atherosclerosis” 招待

    Matsuura E

    St. Thomas’ Hospital Special Lecture. London, UK  2002年9月 

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    記述言語:英語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • ω-Carboxyl variants of 7-ketocholesteryl esters are ligands for β2-GPI.

    Kobayashi K, Liu Q, Yasuda T, Voelker DR, Koike T, Matsuura E

    10th International Congress on Antiphospholipid Antibodies  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • The orientation of β2GPI on the plate is important for the binding of anti-β2GPI autoantibodies by ELISA

    Iverson GM, Matsuura E, Victoria EJ, Cockerill KA, Linnik MD

    International Congress on Antiphospholipid Antibodies, Taormina, Italy  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Clinical significance of serum oxidized LDL in patients with chronic renal disease

    Kasahara J, Kobayashi K, Yamasaki Y, Yasuda T, Koike T, Makino H, Matsuura E

    International Congress on Antiphospholipid Antibodies, Taormina, Italy  2002年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Update “Autoimmunity and atherosclerosis” 招待

    Matsuura E

    National Jewish Center for Immunology and Respiratory Medicine Special Lecture  2002年6月 

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    記述言語:英語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • Use of mutations in domain 1 and domain 4 of β2GPI to determine fine antigenic specificity of antiphospholipid antibodies.

    Iverson M, Matsuura E, Victoria E, Cockerill M, Linnik M

    3rd International Congress on Autoimmunity  2002年2月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • A ligand for β2-glycoprotein I: ω-carboxyl variants of cholesteryl ester.

    Matsuura E, Liu Q, Kobayashi K, Voelker DR, Koike T

    3rd International Congress on Autoimmunity  2002年2月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • An association of IgG laminin-1 autoantibodies with reproductive failure.

    Matsuura E, Inagaki J, Tarakover-Matalon S, Blank M, Aoki K, Koike T, Shoenfeld Y

    3rd International Congress on Autoimmunity  2002年2月 

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  • 抗リン脂質抗体測定法の変遷 招待

    松浦栄次

    日本産科婦人科学会関東連合地方部会・シンポジウム  2001年10月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • 抗リン脂質抗体の多様性と臨床症状の関連:内科的側面から 招待

    松浦栄次

    日本生殖免疫学会総会・シンポジウム  2001年9月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • oxLDL-ligand for β2-glycoprotein I and a possible mechanism on autoantibody-mediated atherosclerosis

    Matsuura E, Kobayashi K, Liu Q, Kasahara J, Inagaki J, Koike T Voelker DR

    Atherosclerosis, Kern-Aspen Lipid Conference, Aspen, USA  2001年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • oxLDL-ligand for β2-glycoprotein I and a possible mechanism on autoantibody-mediated atherosclerosis

    Matsuura E, Kobayashi K, Liu Q, Kasahara J, Inagaki J, Koike T, Voelker DR

    oxLDL-ligand for β2-glycoprotein I and a possible mechanism on autoantibody-mediated atherosclerosis  2001年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 抗リン脂質抗体と動脈硬化症 招待

    松浦栄次

    第45回日本リウマチ学会総会・シンポジウム  2001年5月 

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  • Oxidized autoantigens in atherosclerosis 招待

    Matsuura E

    European Atherosclerosis Society Workshop on the Immune System in Atherosclerosis, Geneva, Switzerland  2001年3月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Autoantibody-dependent uptake of oxidized LDL by macrophages is mediated by oxidized lipid ligands

    Kobayashi K, Matsuura E, Liu Q, Kaihara K, Inagaki J, Kasahara J, Yasuda T, Koike T

    European Atherosclerosis Society Workshop on the Immune System in Atherosclerosis  2001年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Update “Autoimmunity and atherosclerosis" 招待

    Matsuura E

    Ljubliana University Medical Centre Special Lecture  2001年3月 

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    記述言語:英語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • Valine/leucine247 polymorphism of β2-glycoprotein I affects the reactivity of anti-β2-glycoprotein I antibodies

    Yasuda S, Atsumi T, Ichikawa K, Matsuura E, Kaihara K, Yasuda T, Amasaki Y, Koike T

    National Scientific Meeting of American College of Rheumatology, Pennsylvania, USA,  2000年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Valine/leucine polymorphism at position 247 of human β2-glycoprotein I and reactivity of anti-β2-glycoprotein I antibodies

    Yasuda S, Atsumi T, Ichikawa K, Matsuura E, Kaihara K, Takeuchi R, Horita T, Amasaki Y, Ieko M, Yasuda T, Koike T

    International Symposium on Antiphospholipid Antibodies, Tours, France  2000年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-β2-glycoprotein I antibodies in children with atopic dermatitis

    Ambrozic A, Kveder T, Ichikawa K, Avcin T, Matsuura E, Rozman B, Koike T

    International Symposium on Antiphospholipid Antibodies, Tours, France  2000年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-Glycoprtein I- anti-β2-glycoprotein I Interaction

    Koike T, Ichikawa K, Atsumi T, Kasahara H, Matsuura E

    International Symposium on Antiphospholipid Antibodies, Tours, France  2000年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidized low density lipoprotein is a risk factor of arterial thrombosis in antiphospholipid syndrome

    Zhao D, Wang X, Kasahara J, Kobayashi K, Dlott J, Kaihara K, Inagaki J, Yasuda T, Triplett DA, Koike T, Matsuura E

    International Symposium on Antiphospholipid Antibodies, Tours, France  2000年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • A β2-glycoprotein I-specific ligand derived from oxidized LDL: a possible involvement in development of arterial thrombosis/atherosclerosis in the secondary antiphospholipid syndrome

    Matsuura E, Kobayashi K, Liu Q, Kaihara K, Inagaki J, Atsumi T, Yasuda T, Khamashta MA, Hughes GRV, Koike T

    International Symposium on Antiphospholipid Antibodies, Tours, France  2000年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • A chimeric antibody as a putative standard for assays to detect IgG anticardiolipin and anti-β2-glycoprotein I antibodies

    Ichikawa K, Matsuura E, Atsumi T, Amasaki Y, Kobayashi S, Hughes GRV, Khamashta MA, Koike T

    International Symposium on Antiphospholipid Antibodies, Tours, France  2000年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • ブレインサイエンス領域におけるゲノムの機能解析:脳梗塞などの血栓症を引き起こす自己抗体.特異性と抗体測定法 招待

    松浦栄次

    日本生化学会近畿支部会テクニカルセミナー  2000年5月 

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    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • 抗カルジオリピン抗体.特異性と対応抗原 招待

    松浦栄次

    第40回日本リウマチ学会総会  2000年5月 

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    記述言語:日本語   会議種別:シンポジウム・ワークショップ パネル(指名)  

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  • A chimeric antibody with Human γ1 constant region as a putative standard for assays to detect IgG anticardiolipin and anti-β2-glycoprotein I antibodies

    Ichikawa K, Tsutsumi A, Atsumi T, Matsuura E, Kobayashi S, Koike T

    National Scientific Meeting of American College of Rheumatology, Boston, USA  1999年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 抗リン脂質抗体の最近の話題 招待

    松浦栄次

    日本皮膚科学会岡山地方会  1999年9月 

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    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • A possible mechanism on autoimmune-mediated atherosclerosis

    Matsuura E, Kobayashi K, Liu Q, Kaihara K, Inagaki J, Yasuda T, Koike T, Voelker DR

    Atherosclerosis, Gordon Research Conference, Meriden, USA  1999年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 医学分野におけるタンパク質化学:血栓症を引き起こす自己抗体:その特異性と血栓形成の機序 招待

    松浦栄次

    日本高分子学会北海道支部会講演会  1999年1月 

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    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • 抗リン脂質抗体:特異性と血管病変形成の機序 招待

    松浦栄次

    藤田学園医学会  1998年10月 

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    記述言語:日本語   会議種別:公開講演,セミナー,チュートリアル,講習,講義等  

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  • Three-dimensional model of β2-glycoprotein I and electrostatic interactions between its domain IV and V

    Yamamoto D, Matsuura E, Kaihara K, Inagaki J, Kobayashi K, Yasuda T, Ichikawa K, Tsutsumi A, Kasahara H, Koike T

    nternational Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Epitopes on β2-GPI recognized by anticardiolipin antibodies

    Koike T, Ichikawa K, Kasahara H, Atsumi T, Tsutsumi A, Matsuura E

    International Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-β2-glycoprotein I antibodies

    Tsutsumi A, Ichikawa K, Matsuura E, Koike T

    International Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Antiphospholipid antibodies and atherosclerosis 招待

    Matsuura E

    International Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Involvement of β2-glycoprotein I and anti-β2-glycoprotein I in apoptosis

    Kitakawa H, Matsuura E, Inagaki J, Kobayashi K, Kaihara K, Yasuda T, Koike T

    nternational Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • A regulatory mechanism on antigenicity of β2-glycoprotein I by proteolytic cleavage between K317 and T318

    Matsuura E, Inagaki J, Kaihara K, Kobayashi K, Yasuda T, Yamamoto D, Kasahara H, Ichikawa K, Tsutsumi A, Koike T

    International Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Requirement of fatty acid chains derived from acidic phospholipids for the binding of β2-glycoprotein I (β2-GPI) and autoimmune β2-GPI antibodies

    Kobayashi K, Matsuura E, Kaihara K, Inagaki J, Yasuda T, Ichikawa K, Tsutsumi A, Koike T

    International Symposium on Antiphospholipid Antibodies, Sapporo, Japan  1998年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Analysis of a patient with β2-glycoprotein I deficiency

    Yasuda S, Tsutsumi A, Ichikawa K, Miyoshi Y, Horita T, Takeuchi R, Kasahara H, Atsumi T, Matsuura E, Kobayashi S, Koike T

    International Conference on Systemic Lupus Erythematosus. Cancun, Mexico  1998年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Detection of peptide recognized by anticardiolipin antibodies using phage displayed random peptide library

    Kasahara H, Ichikawa K, Tsutsumi A, Matsuura E, Kobayashi S, Koike T

    International Conference on Systemic Lupus Erythematosus. Cancun, Mexico  1998年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Significance of IgG, IgA, and IgM anti-β2-glycoprotein I antibody inpatients with systemic lupus erythematosus

    Tsutsumi A, Ichikawa K, Matsuura E, Horita T, Yasuda S, Takeuchi R, Kasahara H, Atsumi T, Miyoshi Y, Kobayashi S, Koike T

    International Conference on Systemic Lupus Erythematosus. Cancun, Mexico  1998年4月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Characterization on antigenicity of gangliosides by analysis of specific antibodies

    Matsuura E, Kobayashi K, Watarai S, Yasuda T

    Glycolipid and Sphingolipid Biology, Gordon Research Conference, Ventura, USA  1998年1月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Chimeric anticardiolipin antibody consists of human constant regions and the variable region of monoclonal anticardiolipin antibody derived from antiphospholipid syndrome model mouse

    Ichikawa K, Tsutsumi A, Kobayashi S, Matsuura E, Kasahara H, Koike T

    National Scientific Meeting of American College of Rheumatology, Washington DC, USA  1997年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Detection of peptides recognized by anticardiolipin antibodies using phage displayed random peptide library

    Kasahara H, Ichikawa K, Higuchi M, Miyoshi Y, Kitakawa H, Nakabayashi A, Tsutsumi A, Mukai M, Fujisaku A, Matsuura E, Koike T

    National Scientific Meeting of American College of Rheumatology, Washington DC, USA  1997年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 抗リン脂質抗体の対応抗原 招待

    松浦栄次

    日本臨床免疫学会総会・シンポジウム  1997年9月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Down regulation of porcine thyroid peroxidase-induced experimental thyroiditis in transgenic mice producing human alpha-fetoprotein

    Matsuura E, Kang Y, Kitakawa H, Ogata A, Kotani T, Ohtaki S, Nishi S

    International Society for Oncodevelopmental Biology and Medicine, Montreux, Switzerland  1997年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Reactivity of antibodies to DNA insolubilized with alginate

    Kitamura H, Matsuura E, Nagata A, Tokura S, Nishi N

    Nucleic Acids Symposium, Gifu, Japan  1996年11月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-β2-glycoprotein I antibody and lupus anticoagulant in patients with miscarriage

    Ogasawara M, Aoki K, Sasa H, Matsuura E, Yagami Y

    International Symposium on Antiphospholipid Antibodies, New Orleans, USA  1996年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Anti-β2-glycoprotein I antibody: specificity and clinical significance

    Koike T, Matsuura E

    International Symposium on Antiphospholipid Antibodies, New Orleans, USA  1996年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-GPI-dependent anticardiolipin antibodies as a predictor of adverse pregnancy outcomes in a general pregnant population

    Katano K, Aoki K, Sasa H, Ogasawara M, Matsuura E

    International Symposium on Antiphospholipid Antibodies, New Orleans, USA  1996年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Antibodies to β2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus

    Tsutsumi A, Ichikawa K, Matsuura E, Koike T

    International Symposium on Antiphospholipid Antibodies, New Orleans, USA  1996年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidatively modified LDL as a target for β2-glycoprotein I and anti-β2-glycoprotein I antibodies

    Matsuura E, Hasunuma Y, Makita Z, Nishi S, Koike T

    International Symposium on Antiphospholipid Antibodies, New Orleans, USA  1996年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Antibodies having unique specificity induced in mice immunized with human β2-glycoprotein I

    Matsuura E, Hojnik M, Ichikawa K, Tsutsumi A, Nishi S, Koike T

    nternational Symposium on Antiphospholipid Antibodies, New Orleans, USA  1996年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-Glycoprotein I and autoimmunity 招待

    松浦栄次

    The Lake Shirakaba Conference  1996年10月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Anticardiolipin antibodies and β2-glycoprotein I

    Koike T, Matsuura E

    Antiphospholipid Syndrome Symposium at Annual Meeting of the Australian Society of Clinical Immunology and Allergy, Sydney, Australia  1995年10月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Oxidatively modified lipoproteins are subsequently targeted by β2-glycoprotein I and autoantibodies

    Matsuura E, Katahira T, Igarashi Y, Igarashi M, Yasuda T, Koike T

    Lipid Metabolism, Gordon Research Conference, Meriden, USA  1995年6月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • ELISA for anti-β2-glycoprotein I antibodies 招待

    Matsuura E, Nishi S, Koike T, Triplett DA

    LA/Phospholipid Dependent Antibodies, ISTH Scientific Subcommittee Sessions, Barcelona, Spain  1995年6月 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • 2-Glycoprotein I (β2-GPI) reactivity of monoclonal anticardiolipin antibodies from patients with antiphospholipid syndrome

    Ichikawa K, Khamashta MA, Koike T, Matsuura E, Hughes GRV

    International Conference on Systemic Lupus Erythematosus, Jerusalem, Israel  1995年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-glycoprotein I and antiphospholipid syndrome

    Koike T, Matsuura E

    Autoimmunity Meeting. Tel-Hashomer, Israel  1995年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Pathogenic anticardiolipin antibodies in patients with SLE recognize epitopes expressed on β2-glycoprotein I

    Ichikawa K, Matsuura E, Koike T

    International Conference on Systemic Lupus Erythematosus, Jerusalem, Israel  1995年3月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-Glycoprotein I and anticardiolipin antibodies in patients with recurrent spontaneous abortions

    Ozawa N, Makino H, Matsubayashi H, Nozawa S, Matsuura E, Ito H

    International Symposium on Antiphospholipid Antibodies, Leuven, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-Glycoprotein I bound to oxidatively modified lipoproteins could be targeted by anticardiolipin antibodies

    Matsuura E, Katahira Y, Igarashi Y, Koike T

    International Symposium on Antiphospholipid Antibodies, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Recognition of β2-glycoprotein I by monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome

    Ichikawa K, Khamashta MA, Koike T, Matsuura E, Hughes GRV

    International Symposium on Antiphospholipid Antibodies. Leuven, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Molecular studies on phospholipid binding sites and cryptic epitopes appearing on β2-glycoprotein I structure recognized by anticardiolipin antibodies

    Matsuura E, Igarashi M, Ichikawa K, Koike T

    International Symposium on Antiphospholipid Antibodies, Leuven, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Clinical significance of β2-glycoprotein dependent anticardiolipin antibodies in primary and secondary antiphospholipid syndrome

    Kaburaki J, Kuwana M, Yamamoto M, Matsuura E, Ikeda Y

    International Symposium on Antiphospholipid Antibodies, Leuven, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • β2-Glycoprotein I-dependent anticardiolipin antibodies induce factor Xa production in patients with pregnancy loss

    Ogasawara M, Aoki K, Matsuura E, Sasa H, Yagami Y

    International Symposium on Antiphospholipid Antibodies. Leuven, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Clinical survey on antiphospholipid syndrome (APS) in recurrent spontaneous abortion

    Makino T, Matsubayashi H, Ozawa H, Nozawa S, Ikeda Y, Matsuura E

    International Symposium on Antiphospholipid Antibodies. Leuven, Belgium  1994年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Enzyme-linked immunosorbent assay for human pulmonary surfactant protein D

    Nagae H, Matsuura E, Kuroki Y, Fujimoto S, Akino T

    Academic/Industry Joint Conference, Sapporo, Japan  1994年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Surfactant protein D (SP-D) levels in sera of patients with lung diseases

    Honda Y, Kuroki Y, Matsuura E, Takahashi H, Abe S, Akino T

    Academic/Industry Joint Conference, Sapporo, Japan  1994年8月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Surfactant protein D (SP-D) levels in sera of patients with lung diseases

    Honda Y, Kuroki Y, Matsuura E, Inoue T, Takahashi H, Abe S, Akino T

    International Conference of American Association and American Thoracic Society. Boston, USA  1994年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Enzyme-linked immunosorbent assay for human pulmonary surfactant protein D

    Inoue T, Matsuura E, Nagata A, Ogasawara Y, Hattori A, Kuroki Y, Fujimoto S, Akino T

    International Conference of American Association and American Thoracic Society, Boston, USA  1994年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • An infectious type of anti-cardiolipin antibodies is involved in sarcoidosis

    Hasegawa Y, Ina Y, Matsuura E, Takada K, Sato S, Ito H, Kawaguchi H, Morishita M

    International Conference of American Association and American Thoracic Society, Boston, USA  1994年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • 抗リン脂質抗体の対応抗原と測定法 招待

    松浦栄次

    第1回大阪妊娠と免疫研究会  1994年4月 

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    記述言語:日本語   会議種別:口頭発表(招待・特別)  

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  • Antigens targeted by anticardiolipin antibodies 招待

    Matsuura E, Koike T, Triplett DA

    LA/Phospholipid Dependent Antibodies, ISTH Scientific Subcommittee Sessions  1994年 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Anticardiolipin antibodies recognize an altered β2-glycoprotein I structure

    Matsuura E, Igarashi Y, Nagae H, Igarashi M, Koike T

    Congress of International Society on Thrombosis and Haemostasis, New York, USA  1993年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Cofactor-dependent anticardiolipin antibodies can determine a subset in patients with SLE

    Kaburaki J, Ikeda Y, Yamamoto M, Kuwana M, Matsuura E

    ILAR Congress of Rheumatology, Barcelona, Spain  1993年7月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Immunohistochemical localization of pulmonary surfactant protein D (SP-D) in lung carcinomas

    Fujishima T, Shijubo N, Honda Y, Kuroki Y, Matsuura E, Inoue T, Abe S, Akino T

    ALA/ATS International Conference. San Francisco, USA  1993年5月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Clinical significance of cofactor-dependent IgG anti-cardiolipin antibodies in patients with antiphospholipid syndrome

    Kaburaki J, Ikeda Y, Yamamoto M, Watanabe K, Matsuura E

    International Symposium on Antiphospholipid Antibodies, San Antonio, USA  1992年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Cloning and secretion of human β2-glycoprotein I utilizing baculovirus/insect cell expression system

    Matsuura E, Igarashi M, Nagae H, Igarasi Y, Koike T

    International Symposium on Antiphospholipid Antibodies, San Antonio, USA  1992年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • Murine model of antiphospholipid syndrome

    Hashimoto Y, Ichikawa K, Suzuki T, Sumida T, Yoshida S, Matsuura E, Koike T

    International Symposium on Antiphospholipid Antibodies. San Antonio, USA  1992年9月 

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    記述言語:英語   会議種別:口頭発表(一般)  

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  • An alternative ELISA system for detection of anticardiolipin antibodies from patients with antiphospholipid syndrome utilizing solid phase β2-glycoprotein I

    Matsuura E, Igarashi Y, Nagae H, Igarashi M, Koike, T

    International Symposium on Antiphospholipid Antibodies, San Antonio, USA  1992年9月 

     詳細を見る

    記述言語:英語   会議種別:口頭発表(一般)  

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  • Heterogeneity of anticardiolipin antibodies defined by aCL-ELISA utilizing β2-glycoprotein I

    Matsuura E, Igarashi M, Nagae H, Igarashi Y, Koike, T

    International Symposium on Antiphospholipid Antibodies, San Antonio, USA  1992年9月 

     詳細を見る

    記述言語:英語   会議種別:口頭発表(一般)  

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  • Molecular characteristic of the aCL cofactor, β2-glycoprotein I 招待

    Matsuura E, Koike T

    International Congress on Systemic Lupus Erythematosus, London, UK  1992年 

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    記述言語:英語   会議種別:口頭発表(招待・特別)  

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  • Specificity and clinical significance of anticardiolipin autoantibodies detected by an improved ELISA system using the complex of cardiolipin and a cofactor

    Koike T, Suzuki K, Ichikawa K, Fujimoto M, Igarashi Y, Matsuura E

    Congress of International Society on Thrombosis and Haemostasis, Amsterdam, The Netherlands  1991年6月 

     詳細を見る

    記述言語:英語   会議種別:口頭発表(一般)  

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  • Characterization of the anticardiolipin cofactor and a precise assay system for anticardiolipin antibodies in patients with autoimmune diseases

    Matsuura E, Igarashi Y, Fujimoto M, Icikawa K, Suzuki T, Koike T

    Congress of International Society on Thrombosis and Haemostasis, Amsterdam, The Netherlands  1990年6月 

     詳細を見る

    記述言語:英語   会議種別:口頭発表(一般)  

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  • A simple and sensitive radioimmunoassay for adenosine

    Matsuura E, Nakamura T, Ishige H, Yamane R, Fujimoto M

    International Symposium on Adenosine and Adenine Nucleotides. Kobe, Japan  1990年5月 

     詳細を見る

    記述言語:英語   会議種別:口頭発表(一般)  

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  • Improved enzyme immunoassay for anticardiolipin antibody: a high specific assay for antiphospholipid syndrome

    Matsuura E, Igarashi Y, Fujimoto M, Koike T

    International Symposium on Antiphospholipid Antibodies, Sirmione, Italy  1990年4月 

     詳細を見る

    記述言語:英語   会議種別:口頭発表(一般)  

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▼全件表示

産業財産権

  • DNA、ポリペプチド、抗メソセリン抗体、腫瘍イメージング剤及び複合体

    松浦栄次, 小林和子, 竹中文章

     詳細を見る

    出願番号:特願2017-210508  出願日:2017年

    特許番号/登録番号:日本特許:6339283、PCT/JP2018/012391(外国特許:審査中) 

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  • 遺伝子導入りンハ球の移植仁よる細胞療法1、おける治療 効果及びGVHDを可視化するPETイメージング技術

    松浦栄次, 阪口政政清, 公文裕巳, 黄 鵬, 竹中文章

     詳細を見る

    出願人:岡山大学

    出願番号:特願2016-066068  出願日:2016年3月29日

    特許番号/登録番号:特許6707256  登録日:2020年5月22日 

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  • 放射性同位元素製造装置

    竹中文章, 佐々木崇了, 松浦栄次, 公文裕巳, 谷口愛実, 小田 敬, 菅 亨

     詳細を見る

    出願番号:特願2014-189280  出願日:2014年

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  • 89Zrの標識方法、及び89Zrの標識装置

    竹中文章, 松浦栄次, 小田 敬

     詳細を見る

    出願番号:特願2014-191365  出願日:2014年

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  • ポリ乳酸修飾RNAを含有する分子集合体及びそれを用いたRNA送達システム

    大槻高史, 松浦栄次, 小渕浩嗣, 赤星彰也, 小関 英一

     詳細を見る

    出願番号:特願2014-227611  出願日:2014年

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  • 石灰化小球に対する抗体及びその用途

    松浦栄次, 公文裕巳, 小島和夫

     詳細を見る

    出願番号:PCT/2009/054475  出願日:2009年

    特許番号/登録番号:米国特許8410251、日本特許 5739157 

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  • 酸化LDL-β2GPI複合体に対する抗体及びその用途

    松浦栄次, 小島和夫

     詳細を見る

    出願番号:PCT/JP2009/054473  出願日:2009年

    特許番号/登録番号:米国特許8575314、日本特許5616592、中国 特許ZL200980132253.1、英2319869、特許独特許6020 

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  • 新規な酸化LDL 複合体及びその検知方法

    松浦栄次

     詳細を見る

    出願番号:特願2006-149430  出願日:2006年

    特許番号/登録番号:日本特許5110353 

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  • β2-グリコプロテインI に対するリガンド及びその用途

    松浦栄次, 小林和子

     詳細を見る

    出願番号:特願2003-526939  出願日:2003年

    特許番号/登録番号:米国特許7160733、日本特許4272518 

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  • 生体内酸化LDL-β2-グリコプロテインI 複合体の測定法

    松浦栄次

     詳細を見る

    出願番号:2004ー534180  出願日:2003年

    特許番号/登録番号:特許米国特許7160733、日本特許4272518 

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  • 「酸化LDL-CRP 複合体の測定方法及び測定キット

    松浦栄次

     詳細を見る

    出願番号:特願2003-333927  出願日:2003年

    特許番号/登録番号:米国特許7422864、日本特許3898680、欧州(英・ 独・仏)EP1596198  発行日:2007年

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  • 抗ラミニン抗体の測定法およびその応用

    松浦栄次, 稲垣純子, 青木耕治

     詳細を見る

    出願番号:特願2000-355148  出願日:2000年

    特許番号/登録番号:日本特許3989837、米国特許7029867、 

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  • アデノシンの定量法

    中村武志, 松浦栄次

     詳細を見る

    出願番号:特願平01-272537  出願日:1999年

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  • 「酸化リポタンパク質の測定法及びその用途

    松浦栄次, 片平智禎, 小池隆夫

     詳細を見る

    出願番号:特願平07-510213  出願日:1997年

    特許番号/登録番号:米国特許 5900359、日本特許3370334 

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  • 抗リン脂質抗体の測定法及びキット

    松浦栄次, 永江 尚人, 五十嵐 誠, 五十嵐 佳子, 小池 隆夫

     詳細を見る

    出願番号:特願平07-514341  出願日:1995年

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  • ヒト肺サーフアクタントアポ蛋白Dに対するモノクローナル抗体およびその用途

    松浦栄次, 井上 武, 黒木由夫, 秋野豊明

     詳細を見る

    出願番号:特願平06-501331  出願日:1994年

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  • 抗リン脂質抗体結合用担体、それを使用する免疫学的測定およびキツト

    松浦栄次, 五十嵐 佳子, 永江 尚人

     詳細を見る

    出願番号:特願平06-006107  出願日:1994年

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  • ヒト肺サーフアクタントアポ蛋白Dに対するモノクローナル抗体およびその用途

    五十嵐誠, 五十嵐佳子, 永江 尚人, 松浦栄次

     詳細を見る

    出願番号:特願06-501331  出願日:1994年

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  • β2-グリコプロテインIの製造法、それに使用する転移ベクターおよび組換え型バキュロウイルス

    五十嵐 誠, 五十嵐佳子, 永江尚人, 松浦栄次

     詳細を見る

    出願番号:特願平04-152619  出願日:1992年

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  • ヒトβ2-グリコプロテインIに対するモノクローナル抗体およびその用途

    小池隆夫, 松浦栄次, 永江尚人

     詳細を見る

    出願番号:特願平04-508693  出願日:1992年

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  • 抗リン脂質抗体を分類するための方法およびそれに使用するキット

    松浦栄次, 五十嵐佳子, 永江尚人

     詳細を見る

    出願番号:特願平04-056922  出願日:1992年

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  • 感染症患者に特異的に出現する抗体の検出法及びそれに用いるキット

    松浦栄次, 五十嵐佳子

     詳細を見る

    出願番号:特願平02-336634  出願日:1990年

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  • 抗リン脂質抗体結合用担体、それを使用する免疫学的測定法およびキット(2)

    松浦栄次, 五十嵐佳子, 永江尚人

     詳細を見る

    出願番号:特願平02-514157  出願日:1990年

    特許番号/登録番号:日本特許1909614 

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  • 抗リン脂質抗体結合用担体、それを使用する免疫学的測定法及びキット(1)

    松浦栄次, 五十嵐佳子

     詳細を見る

    出願番号:特願平1-272537  出願日:1989年

    特許番号/登録番号:米国特許5506110、ニュージーランド特許237535 

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  • アデノシンの定量法

    中村武志, 松浦栄次

     詳細を見る

    出願番号:特願平01-099095  出願日:1989年

    特許番号/登録番号:日本特許2039266 

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  • 慢性関節リウマチ治療剤

    山本 格, 松浦栄次, 末吉俊幸, 山口知恵子, 土本雅弘

     詳細を見る

    出願番号:特願昭60-060823  出願日:1985年

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▼全件表示

受賞

  • (財)両備檉園記念財団研究助成

    2009年  

    松浦 栄次

     詳細を見る

  • 三共生命科学研究振興財団研究助成

    2002年  

    松浦 栄次

     詳細を見る

  • 日本腫瘤研究所海外渡航助成

    1997年  

    松浦 栄次

     詳細を見る

  • 秋山記念生命科学研究助成

    1995年  

    松浦 栄次

     詳細を見る

  • 日本リウマチ財団研究助成

    1995年  

    松浦 栄次

     詳細を見る

  • 内藤医学研究振興財団助成

    1995年  

    松浦 栄次

     詳細を見る

  • 日本リウマチ学会学会奨励賞

    1993年  

     詳細を見る

    受賞国:日本国

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▼全件表示

共同研究・競争的資金等の研究

  • PET核種の光増感作用を活用し たセラノスティックスのための量子ドットナノマシン

    2018年07月 - 2020年03月

    日本学術振興会  挑戦的萌芽研究 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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  • 細胞膜・血液脳関門通過型Aβ オリゴマーマイクロ抗体による 新規PET画像診断の創出

    2016年04月 - 2019年03月

    日本学術振興会  基盤研究(B) 

    松原悦朗

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    資金種別:競争的資金

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  • 深部・転移がんへのRadioPhotoDynamic(RPD)・Theranosticsを実現する89Zr標識・抗体担持生分解性キャリアの開発

    2016年04月 - 2019年03月

    日本医療研究開発機構  次世代がん医療創成研究事業 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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  • 深部病巣を標的とするTheranosticsに不可欠な新規放射線工学療法の開発

    2016年04月 - 2018年03月

    日本学術振興会  挑戦的萌芽研究 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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  • Theranosticsを実現する89Zr標識による新規抗体・DDSキャリアの開発

    2014年10月 - 2016年03月

    文部科学省・日本医療研究開発機構  次世代がん研究シーズ育成プログラム 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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  • 動脈硬化性疾患の早期診断を可能にする分子イメージング・リピドーム解析技術の構築

    2014年04月 - 2017年03月

    日本学術振興会  基盤研究(A) 

    松浦栄次

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    担当区分:研究代表者  資金種別:競争的資金

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  • 新規核種(89Zr)による抗体PETプローブの開発

    2012年10月 - 2015年09月

    文部科学省・日本医療研究開発機構  研究成果最適展開支援プログラム(A-STEP)【本格研究】(ハイリスク挑戦タイプ) 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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  • 線溶系代謝物を用いる病原性血管新生の標的医療(画像診断と同時治療法)の開発

    2011年04月 - 2014年03月

    日本学術振興会  基盤研究(B) 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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  • 特異抗体によるがんの標的医療(画像診断と同時治療法)の開発

    2011年04月 - 2013年03月

    日本学術振興会  挑戦的萌芽研究 

    松浦栄次

      詳細を見る

    担当区分:研究代表者  資金種別:競争的資金

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▼全件表示

 

担当授業科目

  • 分子イメージング科学実習 (2020年度) 特別  - その他

  • 分子イメージング科学概論 (2020年度) 集中  - その他

  • 分子イメージング科学(演習・実習) (2020年度) 特別  - その他

  • 分子イメージング科学(講義・演習) (2020年度) 特別  - その他

  • 分子医科学演習 (2020年度) 通年  - その他

  • 分子医科学総論 (2020年度) 通年  - その他

  • 生化学 (2020年度) 特別  - その他

  • 生化学 (2020年度) 集中  - その他

  • 生化学・分子医化学実習 (2020年度) 特別  - その他

  • 細胞化学I(演習・実習) (2020年度) 特別  - その他

  • 細胞化学I(講義・演習) (2020年度) 特別  - その他

  • 細胞化学II(演習・実習) (2020年度) 特別  - その他

  • 細胞化学II(講義・演習) (2020年度) 特別  - その他

  • PET科学アカデミー (2020年度) 特別  - その他

▼全件表示