研究者詳細 - 淺田　騰

論文 - 淺田　騰

分割表示 126 件中 1 - 20 件目／全件表示 >>

Antitumor activity of α-pinene in T-cell tumors. 査読国際誌

Masaya Abe, Noboru Asada, Maiko Kimura, Chie Fukui, Daisuke Yamada, Ziyi Wang, Masayuki Miyake, Takeshi Takarada, Mitsuaki Ono, Michinori Aoe, Wataru Kitamura, Masayuki Matsuda, Takashi Moriyama, Akifumi Matsumura, Yoshinobu Maeda

Cancer science 2024年1月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

T-cell acute leukemia and lymphoma have a poor prognosis. Although new therapeutic agents have been developed, their therapeutic effects are suboptimal. α-Pinene, a monoterpene compound, has an antitumor effect on solid tumors; however, few comprehensive investigations have been conducted on its impact on hematologic malignancies. This report provides a comprehensive analysis of the potential benefits of using α-pinene as an antitumor agent for the treatment of T-cell tumors. We found that α-pinene inhibited the proliferation of hematologic malignancies, especially in T-cell tumor cell lines EL-4 and Molt-4, induced mitochondrial dysfunction and reactive oxygen species accumulation, and inhibited NF-κB p65 translocation into the nucleus, leading to robust apoptosis in EL-4 cells. Collectively, these findings suggest that α-pinene has potential as a therapeutic agent for T-cell malignancies, and further investigation is warranted.

DOI： 10.1111/cas.16086

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Bone marrow microenvironment disruption and sustained inflammation with prolonged haematologic toxicity after CAR T-cell therapy. 査読国際誌

Wataru Kitamura, Noboru Asada, Yusuke Naoi, Masaya Abe, Hideaki Fujiwara, Daisuke Ennishi, Hisakazu Nishimori, Keiko Fujii, Nobuharu Fujii, Ken-Ichi Matsuoka, Tadashi Yoshino, Yoshinobu Maeda

British journal of haematology 202 ( 2 ) 294 - 307 2023年3月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Mechanisms of prolonged cytopenia (PC) after chimeric antigen receptor (CAR) T-cell therapy, an emerging therapy for relapsed or refractory diffuse large B-cell lymphoma, remain elusive. Haematopoiesis is tightly regulated by the bone marrow (BM) microenvironment, called the 'niche'. To investigate whether alterations in the BM niche cells are associated with PC, we analysed CD271+ stromal cells in BM biopsy specimens and the cytokine profiles of the BM and serum obtained before and on day 28 after CAR T-cell infusion. Imaging analyses of the BM biopsy specimens revealed that CD271+ niche cells were severely impaired after CAR T-cell infusion in patients with PC. Cytokine analyses after CAR T-cell infusion showed that CXC chemokine ligand 12 and stem cell factor, niche factors essential for haematopoietic recovery, were significantly decreased in the BM of patients with PC, suggesting reduced niche cell function. The levels of inflammation-related cytokines on day 28 after CAR T-cell infusion were consistently high in the BM of patients with PC. Thus, we demonstrate for the first time that BM niche disruption and sustained elevation of inflammation-related cytokines in the BM following CAR T-cell infusion are associated with subsequent PC.

DOI： 10.1111/bjh.18747

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Recent advances in “sickle and niche” research - Tribute to Dr. Paul S Frenette - 査読

Lidiane S. Torres, Noboru Asada, Mitchell J. Weiss, Andreas Trumpp, Toshio Suda, David T. Scadden, Keisuke Ito

Stem Cell Reports 17 ( 7 ) 1509 - 1535 2022年7月

Treatment outcomes of IgG4-producing marginal zone B-cell lymphoma: a retrospective case series 査読

Yuichi Sumii, Noboru Asada, Yasuharu Sato, Koh-ichi Ohshima, Masanori Makita, Yusuke Yoshimoto, Yuka Sogabe, Kenji Imajo, Yusuke Meguri, Daisuke Ennishi, Hisakazu Nishimori, Nobuharu Fujii, Ken-ichi Matsuoka, Tadashi Yoshino, Yoshinobu Maeda

International Journal of Hematology 112 ( 6 ) 780 - 786 2020年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

IgG4-producing marginal zone B-cell lymphomas (MZLs) have been recently proposed as a subtype of MZLs. Despite the abundant literature on pathophysiological features of this type of lymphoma, only a few retrospective studies pertaining to the treatment outcomes have been reported, and its prognosis remains unclear. We retrospectively analyzed seven patients with IgG4-producing MZLs diagnosed at our institute, with specific reference to treatment and outcomes. The median age was 69.0 years (55-79), and all were males. The median follow-up period was 66.6 months (8-121). All patients had localized disease; four patients had tumors of the ocular adnexa, whereas two had retroperitoneal tumors. Five patients were treated with irradiation (30 Gy/15 fr) (n = 4) or surgery (n = 1), resulting in tumor reduction. Two patients were treated by chemotherapy or irradiation. Among them, one commenced rituximab monotherapy, which led to an inadequate reduction of the tumor. Subsequent irradiation induced complete response (CR). The other patient experienced repeated relapses during follow-up and finally achieved CR by combination chemotherapy. Treatment was well tolerated in all cases, and none of the patients showed disease progression at the last follow-up visit. Our results indicate that the standard treatments for MZLs are generally appropriate for IgG4-producing MZL.

DOI： 10.1007/s12185-020-02968-w

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その他リンク： http://link.springer.com/article/10.1007/s12185-020-02968-w/fulltext.html

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression 査読

Qiaozhi Wei, Fumio Nakahara, Noboru Asada, Dachuan Zhang, Xin Gao, Chunliang Xu, Alan Alfieri, N. Patrik Brodin, Samuel E. Zimmerman, Jessica C. Mar, Chandan Guha, Wenjun Guo, Paul S. Frenette

Developmental Cell 53 ( 5 ) 503 - 513.e5 2020年6月

Prospective evaluation of prognostic impact of KIT mutations on acute myeloid leukemia with RUNX1-RUNX1T1 and CBFB-MYH11 査読国際誌

Yuichi Ishikawa, Naomi Kawashima, Yoshiko Atsuta, Isamu Sugiura, Masashi Sawa, Nobuaki Dobashi, Hisayuki Yokoyama, Noriko Doki, Akihiro Tomita, Toru Kiguchi, Shiro Koh, Heiwa Kanamori, Noriyoshi Iriyama, Akio Kohno, Yukiyoshi Moriuchi, Noboru Asada, Daiki Hirano, Kazuto Togitani, Toru Sakura, Maki Hagihara, Tatsuki Tomikawa, Yasuhisa Yokoyama, Norio Asou, Shigeki Ohtake, Itaru Matsumura, Yasushi Miyazaki, Tomoki Naoe, Hitoshi Kiyoi

Blood Advances 4 ( 1 ) 66 - 75 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Society of Hematology

<title>Key Points</title>
KIT exon 17 mutation is a poor prognostic factor in AML patients with RUNX1-RUNX1T1, but not in those with CBFB-MYH11. NRAS mutation is a poor prognostic factor in AML patients with CBFB-MYH11.

DOI： 10.1182/bloodadvances.2019000709

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Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review 査読

Hiroki Kobayashi, Noboru Asada, Takuro Igawa, Masaya Abe, Yusuke Meguri, Daisuke Ennishi, Hisakazu Nishimori, Nobuharu Fujii, Ken-ichi Matsuoka, Tadashi Yoshino, Yoshinobu Maeda

Internal Medicine 59 ( 21 ) 2757 - 2761 2020年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Japanese Society of Internal Medicine

Breast involvement of Adult T-cell leukemia-lymphoma (ATLL) is extremely rare, and the data on the characteristics are limited. We herein describe a 49-year-old woman who presented with skin involvement of ATLL. Positron emission tomography/computed tomography showed bilateral breast lesions. Although the patient once achieved a complete metabolic response, a relapse of her ATLL occurred. The patient received subsequent allogeneic hematopoietic stem cell transplantation (HSCT). To our knowledge, only four cases of ATLL with breast involvement have previously been reported, and the prognoses have generally been poor. Breast lesions of ATLL have aggressive features, and intensive systemic chemotherapy and HSCT are required to improve survival.

DOI： 10.2169/internalmedicine.5077-20

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Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche 査読

Maria Maryanovich, Ali H. Zahalka, Halley Pierce, Sandra Pinho, Fumio Nakahara, Noboru Asada, Qiaozhi Wei, Xizhe Wang, Paul Ciero, Jianing Xu, Avigdor Leftin, Paul S. Frenette

Nature Medicine 24 ( 6 ) 782 - 791 2018年6月

Regulation of malignant hematopoiesis by bone marrow microenvironment 査読

Noboru Asada

Frontiers in Oncology 8 119 2018年4月

The hematopoietic stem cell niche: from embryo to adult. 査読

Gao X, Xu C, Asada N, Frenette PS

Development (Cambridge, England) 145 ( 2 ) 2018年1月

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche. 査読

Guarnerio J, Mendez LM, Asada N, Menon AV, Fung J, Berry K, Frenette PS, Ito K, Pandolfi PP

Nature communications 9 ( 1 ) 66 2018年1月

Complexity of bone marrow hematopoietic stem cell niche 査読

Noboru Asada, Shoichiro Takeishi, Paul S. Frenette

INTERNATIONAL JOURNAL OF HEMATOLOGY 106 ( 1 ) 45 - 54 2017年7月

Differential cytokine contributions of perivascular haematopoietic stern cell niches 査読

Noboru Asada, Yuya Kunisaki, Halley Pierce, Zichen Wang, Nicolas F. Fernandez, Alexander Birbrair, Avi Ma'ayan, Paul S. Frenette

NATURE CELL BIOLOGY 19 ( 3 ) 214 - 223 2017年3月

G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE(2) 査読

Yuko Kawano, Chie Fukui, Masakazu Shinohara, Kanako Wakahashi, Shinichi Ishii, Tomohide Suzuki, Mari Sato, Noboru Asada, Hiroki Kawano, Kentaro Minagawa, Akiko Sada, Tomoyuki Furuyashiki, Satoshi Uematsu, Shizuo Akira, Toshimitsu Uede, Shuh Narumiya, Toshimitsu Matsui, Yoshio Katayama

BLOOD 129 ( 5 ) 587 - 597 2017年2月

Communication of bone cells with hematopoiesis, immunity and energy metabolism. 査読国際誌

Asada N, Sato M, Katayama Y

BoneKEy reports 4 748 - 748 2015年

Regulation of hematopoiesis in endosteal microenvironments 査読

Noboru Asada, Yoshio Katayama

INTERNATIONAL JOURNAL OF HEMATOLOGY 99 ( 6 ) 679 - 684 2014年6月

Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism 査読

Mari Sato, Noboru Asada, Yuko Kawano, Kanako Wakahashi, Kentaro Minagawa, Hiroki Kawano, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Yoshio Katayama

CELL METABOLISM 18 ( 5 ) 749 - 758 2013年11月

Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells 査読

Noboru Asada, Yoshio Katayama, Mari Sato, Kentaro Minagawa, Kanako Wakahashi, Hiroki Kawano, Yuko Kawano, Akiko Sada, Kyoji Ikeda, Toshimitsu Matsui, Mitsune Tanimoto

CELL STEM CELL 12 ( 6 ) 737 - 747 2013年6月

Random skin biopsy and bone marrow biopsy for diagnosis of intravascular large B cell lymphoma 査読

Kosei Matsue, Noboru Asada, Jun Odawara, Takayoshi Aoki, Shun-ichi Kimura, Kan-ichi Iwama, Hideaki Fujiwara, Masayuki Yamakura, Masami Takeuchi

ANNALS OF HEMATOLOGY 90 ( 4 ) 417 - 421 2011年4月

Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche 査読

Yuriko Kawamori, Yoshio Katayama, Noboru Asada, Kentaro Minagawa, Mari Sato, Atsuo Okamura, Manabu Shimoyama, Kimie Nakagawa, Toshio Okano, Mitsune Tanimoto, Shigeaki Kato, Toshimitsu Matsui

BLOOD 116 ( 25 ) 5528 - 5535 2010年12月

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