2021/10/11 更新

写真a

ソガ ヨシヒコ
曽我 賢彦
SOGA Yoshihiko
所属
岡山大学病院 准教授
職名
准教授
外部リンク

学位

  • 博士(歯学) ( 岡山大学 )

研究キーワード

  • 口腔内感染巣

  • compromised patients

  • oral care

  • infection control

  • 口腔ケア

  • 易感染

  • 口腔感染管理

研究分野

  • ライフサイエンス / 保存治療系歯学

  • ライフサイエンス / 保存治療系歯学

学歴

  • 岡山大学    

    - 2002年

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    国名: 日本国

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  • 岡山大学   Graduate School, Division of Dental Research  

    - 2002年

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  • 岡山大学   Faculty of Dentistry  

    - 1998年

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  • 岡山大学   歯学部  

    - 1998年

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    国名: 日本国

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経歴

  • - 岡山大学岡山大学病院医療支援歯科治療部 部長

    2017年

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  • - 岡山大学岡山大学病院 准教授

    2013年

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  • - Associate Professor,University Hospital of Medicine and Dentistry,Okayama University

    2013年

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  • 岡山大学岡山大学病院医療支援歯科治療部 副部長   Okayama University Hospital

    2011年 - 2017年

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  • 岡山大学岡山大学病院 助教   Okayama University Hospital

    2008年 - 2012年

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  • Assistant Professor,University Hospital of Medicine and Dentistry,Okayama University

    2008年 - 2012年

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所属学協会

  • 日本がん口腔支持療法学会

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  • 日本造血細胞移植学会

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  • 日本口腔内科学会

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  • 日本臨床腫瘍学会

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  • Multinational Association of Supportive Care in Cancer

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  • 日本歯周病学会

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  • 岡山歯学会

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  • Multinational Association of Supportive Care in Cancer

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  • 日本歯科医学教育学会

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  • 日本口腔感染症学会

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  • International association of dental research

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  • 日本歯科保存学会

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委員歴

  • 日本造血細胞移植学会   評議員  

    2017年   

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    団体区分:学協会

    日本造血細胞移植学会

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  • Multinational Association of Supportive Care in Cancer   member of the "membership committee"  

    2016年   

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    団体区分:学協会

    Multinational Association of Supportive Care in Cancer

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  • 日本がん口腔支持療法学会   理事長  

    2015年   

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    団体区分:学協会

    日本がん口腔支持療法学会

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  • 岡山歯学会   評議員  

    2013年   

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    団体区分:学協会

    岡山歯学会

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  • 日本歯科保存学会   評議員  

    2009年   

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    団体区分:学協会

    日本歯科保存学会

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書籍等出版物

  • チーム医療のための造血細胞移植ガイドブック -移植チーム・造血細胞移植コーディネーター必携-

    医薬ジャーナル社  2018年 

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  • がん口腔支持療法 多職種連携によるがん患者の口腔内管理

    永末書店  2017年  ( ISBN:4816013288

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  • がん患者の口腔マネージメントテキスト 看護師がお口のことで困ったら

    文光堂  2016年  ( ISBN:4830646799

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  • がん患者の口腔マネージメントテキスト 看護師がお口のことで困ったら

    文光堂  2016年  ( ISBN:4830646799

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  • 多職種協働チーム先制医療での口腔ケアFAQ50

    一世出版  2016年  ( ISBN:4870781808

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  • がん患者の口腔マネージメントテキスト 看護師がお口のことで困ったら

    文光堂  2016年  ( ISBN:4830646799

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  • がんと歯科治療

    デンタルダイヤモンド社  2015年  ( ISBN:9784885103322

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  • MASCC/ISOOがん治療に伴う粘膜障害に対するエビデンスに基づいた臨床診療ガイドライン

    2013年 

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  • 臨床歯周病学 第2版

    医歯薬出版株式会社  2013年  ( ISBN:9784263456620

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  • ビジュアル歯周病を科学する

    クインテッセンス出版  2012年  ( ISBN:4781202543

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  • すべてがわかる最新糖尿病治療・ケア・教育

    照林社  2011年  ( ISBN:4796522476

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  • 糖尿病と酸化ストレス

    メディカルレビュー社  2011年 

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  • Leprosy: Science working towards dignity

    Tokai University Press  2011年 

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  • 歯科衛生士のための歯周治療ガイドブック

    医歯薬出版  2009年 

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  • ザ・ペリオドントロジー

    永末書店  2009年 

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  • 歯周病と7つの病気

    永末書店  2007年 

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MISC

  • Replacing zoledronic acid with denosumab is a risk factor for developing osteonecrosis of the jaw

    Tomoko Higuchi, Yoshihiko Soga, Misato Muro, Makoto Kajizono, Yoshihisa Kitamura, Toshiaki Sendo, Akira Sasaki

    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology   125 ( 6 )   547 - 551   2018年6月

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    記述言語:英語   出版者・発行元:Mosby Inc.  

    Objective: Intravenous zoledronic acid (ZA) is often replaced with subcutaneous denosumab in patients with bone metastatic cancer. Despite their different pharmacologic mechanisms of action, both denosumab and ZA are effective in bone metastasis but cause osteonecrosis of the jaw (ONJ) as a side effect. ZA persists in the body almost indefinitely, whereas denosumab does not persist for long periods. This study evaluated the risks of developing ONJ when replacing ZA with denosumab. Study Design: In total, 161 Japanese patients administered ZA for bone metastatic cancer were enrolled in this single-center, retrospective, observational study. The risk of developing ONJ was evaluated by logistic regression analysis using the following factors: age, gender, cancer type, angiogenesis inhibitors, steroids, and replacement of ZA with denosumab. Results: Seventeen patients (10.6%) developed ONJ. Multiple regression analysis indicated a significant difference in rate of ONJ associated with replacement of ZA with denosumab (odds ratio = 3.81
    95% confidence interval 1.04-13.97
    P =.043). Conclusions: Replacing ZA with denosumab is a risk factor for the development of ONJ. Both binding of bisphosphonate to bone and receptor activator of nuclear factor-κ B ligand inhibition could additively increase the risk of ONJ. We bring the replacement of ZA with denosumab to the attention of clinical oncologists.

    DOI: 10.1016/j.oooo.2018.02.010

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  • Changes in attitudes of first-year dental school students toward end-of-life care after a lecture

    Norihiro Sonoi, Yoshihiko Soga, Jun-ichi Asaumi

    Dental and Craniofacial Research   1 ( 1 )   2018年

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  • Unusual oral mucosal microbiota after hematopoietic cell transplantation with glycopeptide antibiotics: potential association with pathophysiology of oral mucositis

    Misato MURO, Yoshihiko SOGA, Tomoko HIGUCHI, Kota KATAOKA, Daisuke EKUNI, Yoshinobu MAEDA, Manabu MORITA

    Folia Microbiologica   65 ( 5 )   587 - 597   2018年

  • Prevalence of oral health-related conditions that could trigger accidents for patients with moderate-to-severe dementia

    Naoki Kobayashi, Yoshihiko Soga, Kyoko Maekawa, Yuko Kanda, Eiko Kobayashi, Hisako Inoue, Ayana Kanao, Yumiko Himuro, Yumi Fujiwara

    GERODONTOLOGY   34 ( 1 )   129 - 134   2017年3月

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    記述言語:英語   出版者・発行元:WILEY  

    Objective: This study was performed to determine the prevalence of oral health conditions unnoticed by doctors and ward staff that may increase risk of incidents and/or accidents in hospitalised patients with moderate-severe dementia.
    Background data discussing the present status of the field: Dementia patients may not recognise risks in the mouth, such as tooth mobility or ill-fitting dental prostheses and/or dentures. In addition to the risk of choking, injury by sharp edges of collapsed teeth or prosthodontics could pose risks. However, many previous publications were limited to case reports or series.
    Materials and methods: Ninety-two consecutive hospitalised dementia patients (M: 52, F: 40, median age: 82.5 years, range: 62-99 years, from 2011 to 2014), referred for dentistry for dysphagia rehabilitation, were enrolled in this study. Participants referred for dental treatment with dental problems detected by ward staff were excluded. All participants had a Global Clinical Dementia Rating Score >2. Their dental records were evaluated retrospectively for issues that may cause incidents and/or accidents.
    Results: Problems in the mouth, for example tooth stumps, dental caries, and ill-fitting dentures, were detected in 51.1% of participants (47/92). Furthermore, 23.9% (22/92) showed risk factors that could lead to incidents and/or accidents, for example falling out of teeth and/or prosthodontics or injury by sharp edges of teeth and/or prosthodontics.
    Conclusions: Hospitalised moderate-severe dementia patients had a high prevalence of oral health conditions unnoticed by doctors and ward staff that may increase risk of incidents and/or accidents.

    DOI: 10.1111/ger.12235

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  • Examination of Diseases Requiring Oral Surgery Treated via Medical-Dental Cooperation in the Department of Oral and Maxillofacial Surgery(Biopathology), Okayama University Hospital

    Masanori Masui, Tsuyoshi Shimo, Norie Yoshioka, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Mayumi Yao, Shoko Yoshida, Yurika Murase, Koji Kishimoto, Akiyoshi Nishiyama, Yoshihiko Soga, Akira Sasaki

    International Journal of Surgery & Surgical Procedures   2   115   2017年

  • 食道がん治療および発症予防における歯科的支援の意義

    別冊 BIO Clinica 慢性炎症と疾患   6 ( 3 )   140 - 146   2017年

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  • Perioperative Management Center (PERIO) for Neurosurgical Patients

    Takao Yasuhara, Tomohito Hishikawa, Takashi Agari, Kazuhiko Kurozumi, Tomotsugu Ichikawa, Masahiro Kameda, Aiko Shinko, Joji Ishida, Masafumi Hiramatsu, Motomu Kobayashi, Yoshikazu Matsuoka, Toshihiro Sasaki, Yoshihiko Soga, Reiko Yamanaka, Takako Ashiwa, Akemi Arioka, Yasuko Hashimoto, Ayasa Misaki, Yuriko Ishihara, Machiko Sato, Hiroshi Morimatsu, Isao Date

    NEUROLOGIA MEDICO-CHIRURGICA   56 ( 9 )   574 - 579   2016年

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    記述言語:英語   出版者・発行元:JAPAN NEUROSURGICAL SOC  

    Perioperative management is critical for positive neurosurgical outcomes. In order to maintain safe and authentic perioperative management, a perioperative management center (PERIO) was introduced to patients of our Neurosurgery Department beginning in June 2014. PERIO involves a multidisciplinary team consisting of anesthesiologists, dentists/dental hygienists/technicians, nurses, physical therapists, pharmacists, and nutritionists. After neurosurgeons decide on the course of surgery, a preoperative evaluation consisting of blood sampling, electrocardiogram, chest X-ray, and lung function test was performed. The patients then visited the PERIO clinic 7-14 days before surgery. One or two days before surgery, the patients without particular issues enter the hospital and receive a mouth cleaning one day before surgery. After surgery, postoperative support involving eating/swallowing evaluation, rehabilitation, and pain control is provided. The differences in duration from admission to surgery, cancellation of surgery, and postoperative complications between PERIO and non-PERIO groups were examined. Eighty-five patients were enrolled in the PERIO group and 131 patients in the non-PERIO group. The duration from admission to surgery was significantly decreased in the PERIO group (3.6 +/- 0.3 days), compared to that in the non-PERIO group (4.7 +/- 0.2 days). There was one cancelled surgery in the PERIO group and six in the non-PERIO group. Postoperative complications and the overall hospital stay did not differ between the two groups. The PERIO system decreased the duration from admission to surgery, and it is useful in providing high-quality medical service, although the system should be improved so as not to increase the burden on medical staff.

    DOI: 10.2176/nmc.oa.2016-0085

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  • Incidence and Risk Factors of Osteonecrosis of the Jaw in Advanced Cancer Patients after Treatment with Zoledronic Acid or Denosumab: A Retrospective Cohort Study

    Makoto Kajizono, Hikaru Sada, Yuhko Sugiura, Yoshihiko Soga, Yoshihisa Kitamura, Junji Matsuoka, Toshiaki Sendo

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   38 ( 12 )   1850 - 1855   2015年12月

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    記述言語:英語   出版者・発行元:PHARMACEUTICAL SOC JAPAN  

    Zoledronic acid and denosumab are two antiresorptive drugs currently in use for treating osteoporosis. They have different mechanisms of action, but both have been shown to delay the onset of skeletal-related events in patients with advanced cancer. However, medication-related osteonecrosis of the jaw (MRONJ) has been reported in cancer patients treated with zoledronic acid or denosumab. We studied 155 patients with several types of advanced cancer who were treated with zoledronic acid or denosumab in our hospital during the period from April 2010 through March 2013. Thirteen of these 155 patients (8.4%) developed MRONJ. MRONJ development was significantly associated with the number of zoledronic acid or denosumab infusions (p<0.001) and the duration of zoledronic acid or denosumab therapy (p<0.001). Logistic regression analysis showed that diabetes [odds ratio (OR)=6.699, 95% confidence interval (CI), 1.435-31.277, p=0.016], anemia [OR=14.559, 95% CI, 2.161-98.069, p=0.006], and pus discharge [OR=6.491, 95% CI, 1.514-27.835, p=0.012] significantly increased the risk of developing MRONJ. However, the risk of MRONJ was significantly lower [OR=0.137, 95% CI, 0.020-0.944, p=0.043] when patients received periodical dentistry maintenance. Diabetes, anemia, and pus discharge may also play roles in its development. These findings suggest that the active inclusion of dentistry maintenance in bisphosphonate or denosumab treatment of cancer patients can reduce MRONJ development.

    DOI: 10.1248/bpb.b15-00385

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  • Detection of Identical Isolates of Enterococcus faecalis from the Blood and Oral Mucosa in a Patient with Infective Endocarditis

    Akemi Okui, Yoshihiko Soga, Susumu Kokeguchi, Motoko Nose, Reiko Yamanaka, Nobuchika Kusano, Manabu Morita

    INTERNAL MEDICINE   54 ( 14 )   1809 - 1814   2015年

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    記述言語:英語   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    The detection of infective endocarditis (IE) of oral origin has been previously discussed. However, there are few reports confirming this infection using molecular biological techniques. We herein describe the case of a 67-year-old man who developed IE. Blood culture samples and strains obtained from the gingival and buccal mucosa showed 100% identity to Enterococcus faecalis JCM 5803 on sequencing of 16S rRNA gene fragments. A random amplification of polymorphic DNA (RAPD) analysis showed the same pattern for these samples, thus confirming the identity of E. faecalis isolates in the blood and oral mucosa. Our observations provide novel information regarding the level of identity between IE pathogens and oral bacteria.

    DOI: 10.2169/internalmedicine.54.3223

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  • オーラルヘルスケアのコンセプトと実際①大学病院における医学部と連携した歯学部での取り組み

    佐々木朗, 曽我賢彦

    別冊ザ・クインテッセンス 口腔外科 YEAR BOOK 一般臨床家,口腔外科医のための口腔外科ハンドマニュアル'15   47 - 51   2015年

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  • Management of Lacerated and Swollen Tongue after Convulsive Seizure with a Mouth Protector: Interprofessional Collaboration Including Dentists in Intensive Care

    Reiko Yamanaka, Yoshihiko Soga, Yoshie Moriya, Akemi Okui, Tetsuo Takeuchi, Kenji Sato, Hiroshi Morimatsu, Manabu Morita

    ACTA MEDICA OKAYAMA   68 ( 6 )   375 - 378   2014年12月

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    記述言語:英語   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    We encountered a 74-year-old male patient with tongue laceration after convulsive seizures under intensive care. The tongue showed severe swelling, and the right ventral surface had been lacerated by his isolated and pointed right lower canine. Our university hospital has established a perioperative management center, and is promoting interprofessional collaboration, including dentists, in perioperative management. Dentists collaborating in the perioperative management center took dental impressions, with the support of anesthesiologists who opened the patient's jaw under propofol sedation, to produce a mouth protector. By raising the patient's bite, the completed mouth protector prevented the isolated tooth from contacting the tongue and protected the lacerated wound. Use of the mouth protector prevented the lacerated tongue from coming into contact with the pointed tooth, and the tongue healed gradually. These findings underscore that interprofessional collaboration including dentists can improve the quality of medical care.

    DOI: 10.18926/AMO/53027

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  • With regard to our manuscripts on the commercial saliva substitute, Oralbalance®--its formula has been changed

    Sugiura Y, Soga Y, Tanimoto I, Kokeguchi S, Morishige-Nishide S, Itami-Kono K, Takahashi K, Fujii N, Ishimaru F, Tanimoto M, Yamabe K, Tsutani S, Nishimura F, Takashiba S

    Support Care Cancer   22 ( 12 )   3121 - 3122   2014年12月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)  

    DOI: 10.1007/s00520-014-2432-8

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  • Distribution of oral mucosal bacteria with mecA in patients undergoing hematopoietic cell transplantation

    Takayuki Ebinuma, Yoshihiko Soga, Takamaro Sato, Kazuyuki Matsunaga, Chieko Kudo, Hiroshi Maeda, Yoshinobu Maeda, Mitsune Tanimoto, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   22 ( 6 )   1679 - 1683   2014年6月

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    記述言語:英語   出版者・発行元:SPRINGER  

    We recently reported frequent detection of antibiotic-resistant bacteria on the oral mucosa during the period of hematopoietic cell transplantation (HCT) and suggested an association between oral mucositis and antibiotic-resistant bacterial infection. Methicillin-resistant Staphylococcus spp. were frequently detected, and the oral cavity may be a reservoir of the gene mediating methicillin resistance, mecA. Here, we examined the frequency of mecA carriers in patients undergoing HCT.
    Fifty-nine patients (male (M) = 37, female (F) = 22, 47.3 +/- 11.0 years) receiving HCT were enrolled in this study. Buccal swab samples were obtained four times from day -7 to day +20 (once/week), and mecA was detected by PCR. Fifty-two subjects without systemic disease, who completed dental treatment, especially periodontal treatment (M = 21, F = 31, 55.4 +/- 14.2 years), were also enrolled as controls and checked for mecA on the oral mucosa.
    Seventy-six percent (45/59) of the HCT patients carried mecA at least once in the study period (days -7 to +20), while no control subjects had mecA. The frequency of mecA carriers was 19.2 % from days -7 to -1, while it was significantly increased on days +7 to +13 and +14 to +20, with frequencies of 60.9 and 63.2 %, respectively (P < 0.01, ANOVA).
    mecA was detected in oral mucosa of patients undergoing HCT. The high detection frequency of staphylococci resistant to penicillin and beta-lactams in our recent report was supported.

    DOI: 10.1007/s00520-014-2151-1

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  • 口腔ケアとは

    臨牀と研究   91 ( 10 )   1269 - 1273   2014年

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  • Basic Oral Care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: A Position paper from the joint task force of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (・・・

    Sharon Elad, Judith Raber-Durlacher, Michael T Brennan, Deborah P Saunders, Arno AP Mank, Yehuda Zadik, Barry Quinn, Joel B Epstein, Nicole MA Blijlevens, Tuomas Waltimo, Jakob R Passweg, Elvira M Correa, Göran Dahllöf, Karin UE Garming-Legert, Richard M Logan, Carin MJ Potting, Michael Y Shapira, Yoshihiko Soga, Jacqui Stringer, Monique A Stokman, Samuel Vokurka, Elisabeth Wallhult, Noam Yarom, Siri Beier Jensen

    Supportive Care in Cancer   2014年

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    Basic Oral Care for hematology-oncology patients and hematopoietic stem cell transplantation recipients: A Position paper from the joint task force of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO) and the European Group for Blood and Marrow Transplantation (EBMT)

    DOI: 10.1007/s00520-014-2378-x

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  • Cytokine expression in human dermal fibroblasts stimulated with eosinophil cationic protein measured by protein array

    Takamaro Sato, Yoshihiko Soga, Tomoko Yamaguchi, Michio Meguro, Hiroshi Maeda, Joji Tada, Takayuki Otani, Masaharu Seno, Shogo Takashiba

    ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY   31 ( 4 )   271 - 276   2013年12月

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    記述言語:英語   出版者・発行元:ALLERGY IMMUNOL SOC THAILAND,  

    Background: Eosinophil cationic protein (ECP) was reported previously to be involved in allergic inflammation with cytotoxic activity. On the other hand, recent studies showed that ECP did not induce cell death but inhibited the growth of cancer-derived cells. Our previous study indicated that human ECP enhanced differentiation of rat neonatal cardiomyocytes and stress fiber formation in Balb/c 3T3 mouse fibroblasts, while the effects of human ECP on human fibroblasts are unknown.
    Objective: The present study was performed to determine the effects of human ECP on cytokine expression in human fibroblasts by protein array.
    Methods: The effects of recombinant human ECP (rhECP) on normal human dermal fibroblasts (NHDF) were examined by assaying cell growth. Furthermore, cytokine expression of NHDF stimulated by ECP, which could influence cell growth, was evaluated by protein array.
    Results: ECP was not cytotoxic but enhanced the growth of NHDF. The peak rhECP concentration that enhanced the cell counts by 1.56-fold was 100 ng/mL, which was significantly different from cultures without ECP stimulation (ANOVA/ Scheffe's test, P < 0.05). Array analyses indicated that ciliary neurotrophic factor (CNTF), neutrophil-activating peptide (NAP)-2, and neurotrophin (NT)-3 were significantly upregulated in NHDF stimulated with 100 ng/mL ECP compared to those without stimulation.
    Conclusion: ECP is not cytotoxic but enhances the growth of NHDF. CNTF, NAP-2, and NT-3 were suggested to be involved in enhancing the growth of NHDF. These findings will contribute to determination of the role of ECP in allergic inflammation.

    DOI: 10.12932/AP0287.31.4.2013

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  • Occlusion and Weight Change in a Patient After Esophagectomy: Success Derived from Restoration of Occlusal Support

    Reiko Yamanaka, Yoshihiko Soga, Mami Minakuchi, Kumiko Nawachi, Takayuki Maruyama, Takuo Kuboki, Manabu Morita

    INTERNATIONAL JOURNAL OF PROSTHODONTICS   26 ( 6 )   574 - 576   2013年11月

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    記述言語:英語   出版者・発行元:QUINTESSENCE PUBLISHING CO INC  

    Occlusal support may be an important factor affecting nutritional support after major surgery. This report presents a patient who gained body weight after receiving a new prosthesis. The patient was an 82-year-old man with thoracic esophageal carcinoma. He did not have occlusal support because of multiple caries lesions. His body weight slowly increased after surgery, but almost stopped in the period of 54 to 68 days after surgery. After treatment with dentures (day 72 postsurgery), body weight gain was observed again, although his medical treatment had not changed. An appropriate prosthesis could contribute to perioperative nutrition support and may lead to earlier recovery after surgery.

    DOI: 10.11607/ijp.3622

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  • Antibiotic sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation

    Yoshihiko Soga, Yoshinobu Maeda, Mitsune Tanimoto, Takayuki Ebinuma, Hiroshi Maeda, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   21 ( 2 )   367 - 368   2013年2月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:SPRINGER  

    DOI: 10.1007/s00520-012-1602-9

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  • Antibiotic sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation

    Yoshihiko Soga, Yoshinobu Maeda, Mitsune Tanimoto, Takayuki Ebinuma, Hiroshi Maeda, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   21 ( 2 )   367 - 368   2013年2月

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    記述言語:英語   掲載種別:速報,短報,研究ノート等(学術雑誌)   出版者・発行元:SPRINGER  

    DOI: 10.1007/s00520-012-1602-9

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  • Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients

    Judith E. Raber-Durlacher, Inger von Bultzingslowen, Richard M. Logan, Joanne Bowen, Abdul Rahman Al-Azri, Hele Everaus, Erich Gerber, Jess Garcia Gomez, Bo G. Pettersson, Yoshihiko Soga, Fred K. L. Spijkervet, Wim J. E. Tissing, Joel B. Epstein, Sharon Elad, Rajesh V. Lalla

    SUPPORTIVE CARE IN CANCER   21 ( 1 )   343 - 355   2013年1月

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    記述言語:英語   掲載種別:書評論文,書評,文献紹介等   出版者・発行元:SPRINGER  

    The aim of this project was to review the literature and define clinical practice guidelines for the use of cytokines and growth factor agents for the prevention or treatment of oral mucositis induced by cancer chemotherapy or radiotherapy.
    A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible.
    Sixty-four clinical studies across 11 interventions were evaluated. A recommendation was made for the use of recombinant human KGF-1 (palifermin) at a dose of 60 mu g/kg per day for 3 days prior to conditioning treatment and for 3 days post-transplant for prevention of oral mucositis in patients receiving high-dose chemotherapy and total body irradiation followed by autologous stem cell transplantation for hematological malignancies. A suggestion was made against using granulocyte macrophage colony-stimulating factor mouthwash for the prevention of oral mucositis in the setting of high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation. No guideline was possible for any other cytokine or growth factor agents due to inconclusive evidence.
    Of the cytokine and growth factor agents studied for oral mucositis, the evidence only supports use of palifermin in the specific population listed above. Additional well-designed research is needed on other cytokine and growth factor interventions and in other cancer treatment settings.

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  • 周術期医療に歯科の専門性はどう役立つか?

    曽我賢彦

    日本歯科評論   73 ( 5 )   154 - 157   2013年

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  • 岡山大学病院歯科系診療科等が医科系診療科等から受けた院内紹介とそれに対する初動対応 平成22年度と23年度を対象とした実態調査

    山中 玲子, 宇高 惠美子, 吉冨 愛子, 松本 江里子, 曽我 賢彦, 森田 学

    岡山歯学会雑誌   32 ( 2 )   57 - 63   2013年

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  • 頭頸部がん患者に対して口腔ケアを行った2症例

    丸山 貴之, 山中 玲子, 志茂 加代子, 田中 千加, 曽我 賢彦, 森田 学

    日本歯周病学会会誌   55 ( 3 )   262 - 268   2013年

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  • もう一歩先へ -最前線の現場から- 岡山大学病院のチーム医療への取り組み〈前編〉

    森田学, 曽我賢彦, 宮脇卓也, 三浦留美

    デンタルハイジーン   33 ( 8 )   886 - 889   2013年

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  • 特定機能病院における医科歯科連携の中で果たす歯科医療の役割

    曽我賢彦

    歯界展望   ( 特別号 )   240 - 240   2013年

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  • Histological and immunohistochemical features of gingival enlargement in a patient with AML

    Norihiro Sonoi, Yoshihiko Soga, Hiroshi Maeda, Koichi Ichimura, Tadashi Yoshino, Kazutoshi Aoyama, Nobuharu Fujii, Yoshinobu Maeda, Mitsune Tanimoto, Richard Logan, Judith Raber-Durlacher, Shogo Takashiba

    ODONTOLOGY   100 ( 2 )   254 - 257   2012年7月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Here, we discuss the pathophysiology of leukemia-associated gingival enlargement based on a case of acute myelomonocytic leukemia (AML-M4) with typical gingival enlargement. Uniquely, this patient was well enough to allow full periodontal examination and incisional gingival biopsy to be performed both before and after chemotherapy. The patient was a 39-year-old Japanese woman with AML-M4 showing gingival enlargement. Histological and immunohistochemical features of gingiva and bacterial counts in the periodontal pockets were examined before and after chemotherapy. The results were as follows: (1) infiltration of myelomonocytic blasts in enlarged gingiva; (2) resolution of gingival enlargement with complete remission of AML by anticancer chemotherapy; and (3) the numbers of bacteria in the periodontal pockets were not high and were not altered before or after chemotherapy. In patients with AML-M4, remarkable mucosal enlargement is not generally observed in the body except in the gingiva. We hypothesized that antigens derived from periodontal bacteria, even if they are not present in large numbers, could act as chemoattractants for myelomonocytic leukemic cells.

    DOI: 10.1007/s10266-011-0051-0

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  • Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications

    Hideo Nakarai, Akiko Yamashita, Shintaro Nagayasu, Misaki Iwashita, Sonoko Kumamoto, Hideki Ohyama, Masaki Hata, Yoshihiko Soga, Akifumi Kushiyama, Tomoichiro Asano, Yoshimitsu Abiko, Fusanori Nishimura

    INNATE IMMUNITY   18 ( 1 )   164 - 170   2012年2月

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    記述言語:英語   出版者・発行元:SAGE PUBLICATIONS LTD  

    Chronic low-grade infection has been suggested to be associated with metabolic disorder such as diabetes. However, the molecular mechanism underlying this important association is largely unknown. The only clue established so far is that many subjects exhibit elevated levels of C-reactive protein as measured by highly sensitive assay. Here, we hypothesized that adipocyte-macrophage interaction plays a key role in amplifying such low grade infection to the level of influencing metabolic disorders. The presence of macrophages in abdominal adipose tissues was investigated by immunohistochemistry. To see whether molecules associated with acute phase protein, LPS signaling, and persistent recruitment of monocytes, are produced at higher amounts in adipocytes co-cultured with macrophages stimulated with low concentration of LPS (1 ng/ml), we measured serum amyloid A (SAA), LPS binding protein (LBP), soluble CD14 (sCD14), and RANTES levels in culture supernatant of co-cultures. Lastly, we investigated in vivo effect of low-grade LPS infusion on the production of these molecules using obese model mice. The macrophages were certainly identified in abdominal adipose tissues. Investigated molecules, especially LBP, SAA, and RANTES were produced at higher amounts in co-cultures stimulated with LPS compared with the cells without LPS. The ob/ob, and high-fat diet-induced obesity mice produced higher amounts of LBP, SAA, and RANTES one day after LPS infusion (1 ng/ml/g body weight) compared with ob/- and normal-fat fed control mice. Thus, adipocytes and infiltrated macrophages, and their interaction with low endotoxin stimulation appear to play an important role in amplifying and maintaining LPS-induced low-grade inflammation.

    DOI: 10.1177/1753425910393370

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  • 歯科医師臨床研修におけるチーム医療研修プログラム―研修医の関心および理解に与えた効果の検討―

    山中玲子, 曽我賢彦, 吉冨愛子, 白井肇, 鈴木康司, 河野隆幸, 鳥井康弘, 森田学

    日本歯科医学教育学会雑誌   28 ( 2 )   76 - 84   2012年

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  • 多職種連携をいかに教育するか

    日本歯科医学教育学会雑誌   28 ( 3 )   142 - 143   2012年

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  • 周術期の感染予防に歯科の専門性はどう役立つか

    医学のあゆみ   243 ( 8 )   651 - 655   2012年

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  • 診療報酬に、なぜ「周術期口腔機能管理」が取り上げられたの?

    岸本裕充, 曽我賢彦

    エキスパートナース   28 ( 10 )   28 - 31   2012年

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  • 気管挿管における口腔内偶発症防止対策の必要性

    縄稚久美子, 曽我賢彦, 山中玲子, 足羽孝子, 伊藤真理, 佐藤真千子, 窪木拓男, 森田潔

    日集中医療誌   19 ( 3 )   431 - 432   2012年

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  • がん化学療法を受けている患者に対する口腔内管理の意義

    曽我賢彦

    日本歯科評論   72 ( 6 )   147 - 149   2012年

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  • 病院医療支援を目的とした口腔の管理学および専門診療分野の必要性―周術期医療への歯科的介入を例として―

    曽我賢彦

    口腔リハビリ誌   24 ( 1 )   1 - 10   2012年

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  • 岡山大学病院歯科系診療科等が医科系診療科等から受けた院内紹介とそれに対する初動対応 ― 平成22年度を対象とした実態調査―

    曽我賢彦, 藏重惠美子, 山中玲子, 吉冨愛子, 森田学

    岡山歯学会雑誌   31 ( 2 )   67 - 71   2012年

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  • Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation

    Yoshihiko Soga, Yoshinobu Maeda, Fumihiko Ishimaru, Mitsune Tanimoto, Hiroshi Maeda, Fusanori Nishimura, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   19 ( 7 )   995 - 1000   2011年7月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT.
    Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated.
    The changes in detection frequencies of CoNS and alpha-streptococci from before to 3 weeks after HCT were significant (P < 0.05, chi (2) test): 14.5-53.3% and 92.7-53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P < 0.05, chi (2) test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed.
    Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.

    DOI: 10.1007/s00520-010-0923-9

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  • Discovery of a patient with strongly suspected bullous pemphigoid in a ward by oral health care providers

    N. Kanda, Y. Soga, M. Meguro, A. Tanabe, Y. Yagi, Y. Himuro, Y. Fujiwara, S. Takashiba, N. Kobayashi

    INTERNATIONAL JOURNAL OF DENTAL HYGIENE   9 ( 2 )   159 - 162   2011年5月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL  

    Objectives: Oral health care providers may discover systemic diseases incidentally from signs observed in the oral cavity. Here, we report a case in which oral health care providers in a hospital discovered a patient with strongly suspected bullous pemphigoid (BP), which is a relatively rare but important disease, in a ward. Methods: The patient was a 78-year-old Japanese woman admitted to our hospital because of severe Alzheimer's disease. We discovered recurrent ulcers in the oral mucosa and skin when performing oral care in her ward. Biopsy could not be performed safely because of involuntary biting. We performed blood tests for anti-BP180-NC16a antibody, which is autoantibody specific for BP. Results: The patient had a very high anti-BP180-NC16a antibody titre. We consulted a dermatologist regarding her clinical course and the clinical features of the oral mucosa and skin along with blood test results. BP was very strongly suspected. Discussion: In cases in which oral health care providers suspect their patients may have BP, appropriate examination and provision of information to the doctor are important. Oral health care providers should have knowledge about systemic diseases, the signs of which appear in oral cavity to avoid missing important systemic diseases.

    DOI: 10.1111/j.1601-5037.2010.00448.x

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  • Progress of oral care and reduction of oral mucositis-a pilot study in a hematopoietic stem cell transplantation ward

    Yoshihiko Soga, Yuko Sugiura, Kanayo Takahashi, Hitomi Nishimoto, Yoshinobu Maeda, Mitsune Tanimoto, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   19 ( 2 )   303 - 307   2011年2月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Oral mucositis is a common symptomatic complication associated with hematopoietic stem cell transplantation (HCT). We use simple strategies aimed to reduce oral mucositis by keeping the oral cavity clean and moist. Here, we report on the progress of oral care and the changes in the degree of oral mucositis. The purpose of this pilot study is to evaluate the effects of our strategies on the prevalence and the severity of oral mucositis.
    Fifty-three consecutive patients from 2003 to 2006 administered with conventional allogeneic HCT were enrolled in this study. The degree of oral mucositis was evaluated daily in all patients. Our oral care program was divided into two periods: "examination and trial period (2003 and 2004)" and "intensive oral care period (2005 and 2006)." In the latter, an oral care regimen was carried out systematically by a multidisciplinary team.
    Using our oral care strategies, the prevalence of ulcerative oral mucositis was decreased significantly. The rate was reduced from 76% (10 of 13) of patients with ulcerative oral mucositis in 2003 to only 20% (3 of 15) in 2006.
    Our pilot study suggests that oral mucositis in HCT patients can be alleviated by simple strategies aimed at keeping the oral cavity clean and moist.

    DOI: 10.1007/s00520-010-1002-y

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  • 生活習慣病における骨と歯 II.歯 4.歯周病と糖尿病

    西村英紀, 曽我賢彦

    Bone   25 ( 4 )   427 - 431   2011年

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  • Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT

    K. Yamabe, H. Maeda, S. Kokeguchi, Y. Soga, M. Meguro, K. Naruishi, S. Asakawa, S. Takashiba

    MOLECULAR ORAL MICROBIOLOGY   25 ( 2 )   112 - 122   2010年4月

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    記述言語:英語   出版者・発行元:WILEY-BLACKWELL PUBLISHING, INC  

    P>Methanobrevibacter oralis is an archaeal species frequently isolated from sites of severe periodontitis. However, its pathogenic roles remain unclear. Here, we aimed to isolate group II chaperonin from M. oralis and examine its antigenicity. The genes encoding two chaperonin subunits (Cpn-1 and Cpn-2) were cloned from M. oralis using polymerase chain reaction and genome walking procedures. Recombinant proteins Cpn-1 and Cpn-2 were generated, and the reactivities of sera from patients with periodontitis were examined by Western immunoblotting. The open reading frames of Cpn-1 and Cpn-2 genes consisted of 1641 and 1614 base pairs, respectively. Putative ATP-binding domains conserved among the chaperonin family were observed in both genes. The deduced amino acid sequences of the two genes showed 28.8-40.0% identity to each of the subunits of human CCT (CCT1-8). Thirty and 29 of 36 patients' sera reacted with the recombinant Cpn-1 and recombinant Cpn-2, respectively. Western immunoblotting using antiserum against human CCT subunits indicated that anti-CCT3 and anti-CCT8 antibodies recognized recombinant Cpn-1. In addition, anti-CCT1, CCT3, CCT6, and CCT8 antibodies recognized an antigen of approximately 60 kDa in M. oralis. The results suggested that the chaperonin subunits of M. oralis were antigenic molecules that were recognized by periodontitis patients and that may cross-react with human chaperonin CCT.

    DOI: 10.1111/j.2041-1014.2009.00548.x

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  • Total bacterial counts on oral mucosa after using a commercial saliva substitute in patients undergoing hematopoietic cell transplantation

    Yuko Sugiura, Yoshihiko Soga, Kokoro Yamabe, Soichiro Tsutani, Ichiro Tanimoto, Hiroshi Maeda, Susumu Kokeguchi, Nobuharu Fujii, Fumihiko Ishimaru, Mitsune Tanimoto, Fusanori Nishimura, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   18 ( 3 )   395 - 398   2010年3月

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    記述言語:英語   出版者・発行元:SPRINGER  

    The commercial saliva substitute OralbalanceA (R) has been reported to alleviate symptoms of postradiotherapy xerostomia in head and neck cancer patients. OralbalanceA (R) may also be effective for xerostomia in patients undergoing hematopoietic cell transplantation (HCT) with high-dose chemotherapy and total-body irradiation. However, HCT patients are in a severely compromised condition, and saliva substitute must not promote infection. We reported previously that OralbalanceA (R) has antimicrobial effects against microbial species detected during HCT in vitro. This study was performed to determine the in vivo effects of OralbalanceA (R) on oral mucosal total bacterial counts in patients undergoing HCT.
    A total of 18 neutropenic patients undergoing HCT were enrolled in this study. Before and after 1 week of OralbalanceA (R) use, bacterial samples were obtained from patients by wiping an area of I center dot 1 cm on the buccal mucosa with sterilized cotton swabs. Total bacterial counts of the obtained samples were examined by quantitative polymerase chain reaction amplification of the bacterial 16S ribosomal RNA gene. As controls, bacterial samples were also obtained from ten healthy subjects, and total bacterial counts were examined.
    No significant increase in bacterial count was observed with use of OralbalanceA (R). None of the patients showed bacterial counts above the range found in healthy controls after using OralbalanceA (R).
    In neutropenic patients undergoing HCT, OralbalanceA (R) did not increase the total counts of oral mucosal bacteria beyond the range found in healthy controls. Oral care using OralbalanceA (R) may alleviate the symptoms induced by hyposalivation without promoting infection.

    DOI: 10.1007/s00520-009-0789-x

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  • Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen

    Kanayo Takahashi, Yoshihiko Soga, Yumeno Murayama, Mika Udagawa, Hitomi Nishimoto, Yuko Sugiura, Yoshinobu Maeda, Mitsune Tanimoto, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   18 ( 1 )   115 - 119   2010年1月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Severe oral mucositis induced by allogeneic hematopoietic cell transplantation (HCT) is associated with intolerable pain and risk of systemic bacteremia infection. Differences between conventional HCT and reduced-intensity regimens for allogeneic HCT (RIST) may influence the occurrence and severity of oral mucositis. Here, we evaluated oral mucositis in patients undergoing RIST and compared the results with those in conventional allogeneic HCT patients to facilitate predictive measures for mucositis.
    A total of 127 consecutive patients undergoing HCT (conventional, 63; RIST, 64) were included in this study. Severity of oral mucositis during HCT period was evaluated daily. Differences in severity of mucositis among HCT types were analyzed. Use of morphine to control pain due to oral mucositis was evaluated in each HCT method.
    The severity of oral mucositis was reduced in patients undergoing RIST. Worsening of oral mucositis was delayed in patients receiving RIST. Use of morphine to control pain due to oral mucositis was significantly decreased in patients undergoing RIST compared with those receiving conventional allogeneic HCT.
    The severity of oral mucositis was reduced and the peak day of oral mucositis was delayed in RIST patients compared with those receiving conventional HCT.

    DOI: 10.1007/s00520-009-0637-z

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  • 【歯周医学(Periodontal Medicine) 歯周病と全身疾患】 歯周病と糖尿病

    西村英紀, 曽我賢彦

    医学のあゆみ   232 ( 3 )   167 - 171   2010年

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  • 知ってるようで意外と答えられない よく使う医科用語 CRP

    曽我賢彦

    歯科衛生士   34 ( 4 )   84 - 84   2010年

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  • 特集 糖尿病第6の合併症--歯周病 歯周病と糖尿病の相互作用のメカニズム

    曽我賢彦, 西村英紀

    月刊糖尿病   2 ( 13 )   33 - 42   2010年

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  • 医療の"いま"を伝える 周術期における医科-歯科連携 病院医療への歯科衛生士の参画

    曽我賢彦

    歯科衛生士   34 ( 11 )   70 - 74   2010年

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  • 移植後合併症の看護ポイント - GVHD ③ 口腔GVHD

    造血細胞移植now & future   2010年

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  • 無理のない口腔ケアの実践(第2回) 前頭側頭型/アルツハイマー型認知症に対応した口腔ケアの評価と訓練法 自立した歯磨き行為を維持する認知リハビリテーション

    椿坂康之, 村松真澄, 曽我賢彦, 小林直樹

    臨床老年看護   17 ( 5 )   103 - 110   2010年

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  • 血液がんの副作用対策 ~移植・化学療法の口腔ケア~

    曽我賢彦

    Newsletter ひろば   2 - 11   2010年

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  • Febrile neutropenia and periodontitis: lessons from a case periodontal treatment in the intervals between chemotherapy cycles for leukemia reduced febrile neutropenia

    Yoshihiko Soga, Yoshiko Yamasuji, Chieko Kudo, Kaori Matsuura-Yoshimoto, Kokoro Yamabe, Yuko Sugiura, Yoshinobu Maeda, Fumihiko Ishimaru, Mitsune Tanimoto, Fusanori Nishimura, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   17 ( 5 )   581 - 587   2009年5月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Oral and systemic infections arising from the oral cavity are significant problems in clinical management of patients undergoing leukemia treatment. However, there is significant disparity in the reported incidences of development of periodontal infections. Evidence is limited to those showing the systemic influence of periodontal infection in neutropenic patients. This study indicated an association between febrile neutropenia (FN) and periodontitis in a case in which periodontal treatment in the intervals between chemotherapy cycles reduced FN in subsequent courses of chemotherapy and hematopoietic transplantation (HCT).
    Periodontal treatment was performed in a 61-year-old man with advanced periodontitis, who received HCT following three cycles of chemotherapy. After recovery from neutropenia induced by initial chemotherapy, periodontal treatment was performed in each chemotherapy interval period. Following extraction of teeth with severe advanced periodontitis, all teeth were subjected to periodontal pocket curettage and root planning, which are common periodontal treatments to reduce periodontal pockets harboring anaerobic periodontal bacteria, before HCT.
    Periodontal treatment successfully reduced periodontal pockets from 4.1 +/- 1.5 mm to 3.0 +/- 0.6 mm, which was almost within the healthy range (< 3.0 mm), before HCT. The frequency of FN decreased significantly with increasing cycles of chemotherapy, and decreases in FN corresponded to progress of periodontal treatment. Blood cultures obtained a total of 12 times throughout leukemia treatment were all negative.
    The observations reported here indicate the importance of periodontal treatment in clinical management of patients undergoing leukemia treatment to prevent FN, although all blood cultures were negative.

    DOI: 10.1007/s00520-008-0532-z

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  • Assessment of Chromosome 19 for Genetic Association in Severe Chronic Periodontitis

    Koichi Tabeta, Yasuko Shimada, Hideaki Tai, Yuichi Ishihara, Toshihide Noguchi, Yoshihiko Soga, Shogo Takashiba, Genki Suzuki, Terukazu Kobayashi, Akira Oka, Tetsuo Kobayashi, Kazuhisa Yamazaki, Hidetoshi Inoko, Hirornasa Yoshie

    JOURNAL OF PERIODONTOLOGY   80 ( 4 )   663 - 671   2009年4月

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    記述言語:英語   出版者・発行元:AMER ACAD PERIODONTOLOGY  

    Background: A genome-association study is a powerful toot for analyzing small gene effects in complex diseases such as chronic periodontitis (CP), although the cost of analysis is prohibitive. We designed a study using the DNA pooling method, which could be a breakthrough in lowering such costs. This study was conducted to assess the genetic association in severe CP in a Japanese population.
    Methods: We adopted a DNA pooling method by genotyping 454 densely spaced microsatellite (MS) markers in chromosome 19 as a pilot study, with the possibility of future use in a whole-genome study. This can reduce the high cost and technical burden, which is generally unavoidable in a genomic association study. Pooled DNA samples from 300 case subjects, 300 control subjects, and 200 systemically healthy subjects were screened by genotyping MS markers. The case-control association in the candidate region was analyzed by individual typing of MS and single nucleotide polymorphisms (SNPs).
    Results: The single MS marker allele 17 of 1902G31 was isolated in association with severe CP (P = 0.0012 for 2 x 2; P<0.046 for 2 x m, where m refers to the number of polymorphic alleles observed in a population). No other SNP or MS polymorphism hypothesized to affect biologic functions in the critical region was found in the linkage disequilibrium block analysis.
    Conclusions: We efficiently isolated the susceptible locus for severe CP in chromosome 19 and identified a useful marker to evaluate the risk for disease. This approach can be applied to a whole-genome study in severe CP. J Periodontol 2009;80:663-671.

    DOI: 10.1902/jop.2009.080516

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  • 【病棟でもココまでできる口腔ケア実践ガイド】 症状別基本ケア 口内炎・口腔内潰瘍

    曽我賢彦, 杉浦裕子, 高橋郁名代

    ナーシング・トゥデイ   24 ( 12 )   6 - 7   2009年

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  • 【病棟でもココまでできる口腔ケア実践ガイド】 症状別基本ケア 出血

    曽我賢彦, 杉浦裕子, 高橋郁名代

    ナーシング・トゥデイ   24 ( 12 )   7 - 8   2009年

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  • 【病棟でもココまでできる口腔ケア実践ガイド】 症状・状態別 口腔ケア応用編 口内炎・口腔内潰瘍のケア

    曽我賢彦, 杉浦裕子, 高橋郁名代

    ナーシング・トゥデイ   24 ( 12 )   52 - 55   2009年

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  • 【病棟でもココまでできる口腔ケア実践ガイド】 症状・状態別 口腔ケア応用編 口腔内の出血のケア

    曽我賢彦, 杉浦裕子, 高橋郁名代

    ナーシング・トゥデイ   24 ( 12 )   56 - 59   2009年

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  • Periodontal disease: Chronic low-grade inflammation accelerating aging

    Fusanori Nishimura, Yoshihiko Soga, Akiko Yamashita

    Inflammation and Regeneration   29 ( 3 )   186 - 189   2009年

  • 【歯科衛生士のためのペリオドンタルメディシン 全身の健康と歯周病とのかかわり】 歯周医学をひもとく 理論と根拠を学ぶ 誤嚥性肺炎と歯周病

    高柴正悟, 曽我賢彦

    デンタルハイジーン別冊歯科衛生士のためのペリオドンタルメディシン   90 - 95   2009年

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  • 【歯科衛生士のためのペリオドンタルメディシン 全身の健康と歯周病とのかかわり】 歯周医学をひもとく 理論と根拠を学ぶ 誤嚥性肺炎予防としての口腔ケアのあゆみ

    高柴正悟, 曽我賢彦

    デンタルハイジーン別冊歯科衛生士のためのペリオドンタルメディシン   95 - 95   2009年

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  • DNA microarray analyses of genes expressed differentially in 3T3-L1 adipocytes co-cultured with murine macrophage cell line RAW264.7 in the presence of the toll-like receptor 4 ligand bacterial endotoxin

    A. Yamashita, Y. Soga, Y. Iwamoto, T. Asano, Y. Li, Y. Abiko, F. Nishimura

    INTERNATIONAL JOURNAL OF OBESITY   32 ( 11 )   1725 - 1729   2008年11月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Recent studies have suggested that macrophages were integrated into adipose tissues to interact with adipocytes, thereby exacerbating inflammatory responses. Furthermore, both adipocytes and macrophages appear to express toll-like receptor-4 (TLR-4), and free fatty acids may stimulate cells through TLR-4. Herein, we analyzed genes differentially expressed in adipocytes when co-cultured with macrophages in the presence of a ligand for TLR-4, bacterial lipopolysaccharide (LPS). RAW264.7, a murine macrophage cell line and differentiated 3T3-L1 adipocytes were co-cultured using a transwell system. Genes differentially expressed in adipocytes were analyzed by the DNA microarray method following 4, 8, 12 and 24 h stimulation with 1 ng ml(-1) of Escherichia coli LPS. Randomly selected genes with high expressions were confirmed by quantitative methods at both the gene and the protein level. Co-culture of macrophages and adipocytes with a low LPS concentration (1 ng ml(-1)) markedly upregulated gene expressions associated with inflammation and/or angiogenesis, such as those of interleukin-6 (IL-6), MCP-1, RANTES and CXCL1/KC, in adipocytes. Furthermore, several genes associated with insulin resistance were differentially expressed. Upregulations of genes encoding MCP-1, RANTES and CXC/KC were confirmed by quantitative methods. These results suggest that ligands for TLR-4 stimulate both adipocytes and macrophages to upregulate the expressions of many genes associated with inflammation and/or angiogenesis.

    DOI: 10.1038/ijo.2008.153

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  • Evaluation of xerostomia in hematopoietic cell transplantation by a simple capacitance method device

    Yuko Sugiura, Yoshihiko Soga, Sachiko Nishide, Kotoe Kono, Kanayo Takahashi, Nobuharu Fujii, Fumihiko Ishimaru, Mitsune Tanimoto, Fusanori Nishimura, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   16 ( 10 )   1197 - 1200   2008年10月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Goals Hematopoietic cell transplantation (HCT) may lead to the development of xerostomia. However, there have been few reports of xerostomia in HCT patients based on objective data. We investigated moisture in the oral mucosa in patients undergoing HCT by the capacitance method using a convenient device, Moisture Checker for Mucus (R) (MCM; Life Co., Ltd., Saitama, Japan).
    Subjects and methods Thirty-six patients undergoing HCT at Okayama University Hospital of Medicine and Dentistry (Male=22, Female=14; age=41.6 +/- 16.2 years old) were enrolled in this study. Moisture in the oral mucosa was measured by MCM in accordance with the manufacturer's instructions. The results were obtained as MCM values (%), which are the weight percentage of water content in the oral mucosal epithelium. As controls, moisture of the oral mucosa was also examined in healthy volunteers (Male=27, Female=35; age=43.0 +/- 14.6 years old).
    Main results Throughout the examination period, MCM values were significantly lower in patients who underwent HCT than in controls. The degree of mucosal moisture in HCT patients showed wide interindividual differences.
    Conclusion The degree of mucosal moisture in HCT patients was low and showed wide interindividual differences. Evaluation of xerostomia using such a device may contribute to appropriate oral care with saliva substitute.

    DOI: 10.1007/s00520-008-0470-9

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  • Antimicrobial effects of the saliva substitute, Oralbalance (R), against microorganisms from oral mucosa in the hematopoietic cell transplantation period

    Yuko Sugiura, Yoshihiko Soga, Ichiro Tanimoto, Susumu Kokeguchi, Sachiko Nishide, Kotoe Kono, Kanayo Takahashi, Nobuharu Fujii, Fumihiko Ishimaru, Mitsune Tanimoto, Kokoro Yamabe, Soichiro Tsutani, Fusanori Nishimura, Shogo Takashiba

    SUPPORTIVE CARE IN CANCER   16 ( 4 )   421 - 424   2008年4月

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    記述言語:英語   出版者・発行元:SPRINGER  

    Goals The commercially available saliva substitute Oralbalance (R) has been reported to alleviate symptoms of post-radiotherapy xerostomia in head and neck cancer patients. Oralbalance (R) may also be effective for xerostomia in patients undergoing hematopoietic cell transplantation (HCT) with high-dose chemotherapy and total-body irradiation. However, HCT patients are severely compromised, and saliva substitute must therefore not promote infection. This study was performed to determine the effects of Oralbalance (R) on microbial species identified during HCT.
    Patients and methods Microbial identification of oral mucosa was performed in 28 patients undergoing HCT. The antimicrobial effects of Oralbalance (R) against bacteria and fungi detected in the HCT period were examined in vitro. Briefly, bacteria and fungi were spread on agar plates, and 0.1g of Oralbalance (R) gel was applied (about phi 1cm). After incubation at 37 degrees C for 24h, the presence of a transparent zone of inhibition around Oralbalance (R) was observed.
    Main results Not only bacterial species constituting normal flora of the oral mucosa but also those not usually constituting normal flora, e.g., coagulase-negative Staphylococcus, were detected. A transparent zone was observed around Oralbalance (R) in all bacterial species examined. No transparent zone was observed for Candida albicans, but growth was inhibited in the area where Oralbalance (R) was applied.
    Conclusions Oralbalance (R) does not facilitate increases in microorganisms in the HCT period. Oral care with Oralbalance (R) does not promote infection in patients undergoing HCT.

    DOI: 10.1007/s00520-007-0391-z

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  • Polymorphisms in the 5 ' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population

    Kazu Takeuchi-Hatanaka, Hideki Ohyama, Fusanori Nishimura, Nahoko Kato-Kogoe, Yoshihiko Soga, Sho Matsushita, Keiji Nakasho, Koji Yamanegi, Naoko Yamada, Nobuyuki Terada, Shogo Takashiba

    JOURNAL OF CLINICAL PERIODONTOLOGY   35 ( 4 )   317 - 323   2008年4月

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING  

    Objectives: The expression of interleukin (IL)-12R beta 2 molecule is a crucial regulatory factor in the T-helper type (Th) 1 differentiation of T cells. To elucidate the role of the cell-mediated immune (CMI) response in the pathogenesis of periodontitis, Japanese periodontal patients were subjected to single nucleotide polymorphism (SNP) analyses of the 5' flanking region of IL12RB2, whose variants are frequently detected in lepromatous leprosy patients, in which the very weak cellular immune response is caused by low expression of IL-12R beta 2.
    Material and Methods: The gene polymorphisms of the 5' flanking region of IL12RB2 were examined in subjects with several types of periodontal disease and in healthy controls. Serum immunoglobulin (Ig) G antibody titres against periodontopathic bacteria were measured and compared in periodontal patients with and without variant alleles of IL12RB2.
    Results: The frequencies of variant alleles of IL12RB2 were significantly higher in aggressive periodontitis patients as compared with healthy controls or chronic periodontitis patients. Serum IgG titres against all periodontal bacteria examined in subjects carrying variant alleles were higher than those in subjects without variant alleles.
    Conclusion: IL-12R beta 2 SNPs could be useful as genetic markers to access the susceptibility of the general population to periodontal disease. Low CMI responses or high humoral responses are associated with the pathogenesis of inflammatory periodontal diseases.

    DOI: 10.1111/j.1600-051X.2008.01208.x

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  • Appearance of multidrug-resistant opportunistic bacteria on the gingiva during leukemia treatment

    Yoshihiko Soga, Takashi Saito, Fusanori Nishimura, Fumihiko Ishimaru, Junji Mineshiba, Fumi Mineshiba, Hirokazu Takaya, Hideaki Sato, Chieko Kudo, Susumu Kokeguchi, Nobuharu Fujii, Mitsune Tanimoto, Shogo Takashiba

    JOURNAL OF PERIODONTOLOGY   79 ( 1 )   181 - 186   2008年1月

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    記述言語:英語   出版者・発行元:AMER ACAD PERIODONTOLOGY  

    Background: Dentists generally recognize the importance of periodontal treatment inpatients with leukemia, with the most attention paid to preventing the development of odontogenic infection. For physicians, the worst type of infection is one caused by multidrug-resistant bacteria. Here, we report a patient with an abnormal increase in multidrug-resistant opportunistic bacteria in the gingiva during hematopoietic cell transplantation (HCT).
    Methods: A 53-year-old woman receiving HCT for leukemia had an insufficient blood cell count for invasive periodontal treatment before HCT. Even brushing caused difficulties with hemostasis. Therefore, frequent pocket irrigation and local minocycline administration were performed.
    Results: The multidrug-resistant opportunistic bacterium Stenotrophomonas maltophilia was detected first in phlegm 2 days before HCT, and it was detected in a gingival smear and a blood sample 7 and I I days after HCT, respectively. The patient developed sepsis on day I I and died 14 days after HCT. Frequent irrigation and local antibiotic application were ineffective against S. maltophilia on the gingiva. Inflammatory gingiva without scaling and root planing showed bleeding tendency, and this interfered with the eradication of this bacterium.
    Conclusions: The gingiva in patients undergoing leukemia treatment acts as sites of proliferation and reservoirs for multidrug-resistant opportunistic bacteria. Severe systemic infection by multidrug-resistant bacteria in such patients with leukemia also may involve the gingiva. To prevent abnormal increases in such bacteria on the gingiva, scaling and/or root planing before chemotherapy, which reduces bleeding on brushing during the neutropenic period caused by chemotherapy, may contribute to infection control in such patients, although it was impossible in this case.

    DOI: 10.1902/jop.2008.070205

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  • 糖尿病合併症・歯科治療の新たな展開;糖尿病学習コーナー「歯に要注意! 講義編」.

    曽我賢彦, 高柴正悟

    べんちのーと   20 ( 1 )   16 - 17   2008年

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  • 糖尿病と歯周病

    西村英紀, 曽我賢彦, 山下明子, 岩本義博

    DIABETES JOURNAL (糖尿病と代謝)   36 ( 1 )   9 - 13   2008年

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  • 薬物誘発性歯肉増殖症の発症に関与する遺伝子多型の検索 α2インテグリン+1648G/A遺伝子多型.

    美原, 和田]智恵, 板東美香, 片岡正俊, 久保田健彦, 板垣真奈美, 島田靖子, 田井秀明, 吉江弘正, 西村英紀, 曽我賢彦, 高柴正悟, 永田俊彦, 木戸淳一

    日本歯科保存学雑誌   51 ( 4 )   464 - 471   2008年

  • Macrophage-adipocyte interaction: Marked interleukin-6 production by lipopolysaccharide

    Akiko Yamashita, Yoshihiko Soga, Yoshihiro Iwamoto, Sayuri Yoshizawa, Hirotaka Iwata, Susumu Kokeguchi, Shogo Takashiba, Fusanori Nishimura

    OBESITY   15 ( 11 )   2549 - 2552   2007年11月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    Objective: Recent studies suggested macrophages were integrated in adipose tissues, interacting with adipocytes, thereby exacerbating inflammatory responses. Persistent low-grade infection by gram-negative bacteria appears to promote atherogenesis. We hypothesized a ligand for toll-like receptor 4 (TLR4), bacterial lipopolysaccharide (LPS), would further exaggerate macrophage-adipocyte interaction.
    Research Methods and Procedures: RAW264.7 macrophage cell line and differentiated 3T3-L1 preadipocytes were co-cultured using transwell system. As a control, each cell was cultured independently. After incubation of the cells with or without Escherichia coli LPS, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production was evaluated.
    Results: Co-culture of macrophages and adipocytes with low concentration of Escherichia coli LPS (1 ng/mL) markedly up-regulated IL-6 production (nearly 100-fold higher than that of adipocyte culture alone, p < 0.01), whereas TNF-alpha production was not significantly influenced. This increase was partially inhibited by anti-TNF-alpha neutralizing antibody. Recombinant TNF-a and LPS synergistically upregulated IL-6 production in adipocytes. However, this increase did not reach the level of production observed in co-cultures stimulated with LPS.
    Discussion: A ligand for TLR-4 stimulates macrophages to produce TNF-alpha. TNF-alpha, thus produced, cooperatively upregulates IL-6 production with other soluble factors secreted either from adipocytes or macrophages in these cells. Markedly up-regulated IL-6 would greatly influence the pathophysiology of diabetes and its vascular complications.

    DOI: 10.1038/oby.2007.305

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  • The periodontal host response with diabetes

    Fusanori Nishimura, Yoshihiro Iwamoto, Yoshihiko Soga

    PERIODONTOLOGY 2000   43 ( 1 )   245 - 253   2007年

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    記述言語:英語   出版者・発行元:BLACKWELL PUBLISHING  

    DOI: 10.1111/j.1600-0757.2006.00171.x

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  • High glucose up-regulates lipopolysaccharide-stimulated inflammatory cytokine production via c-jun N-terminal kinase in the monocytic cell line THP-1

    Hirotaka Iwata, Yoshihiko Soga, Michio Meguro, Sayuri Yoshizawa, Yuka Okada, Yoshihiro Iwamoto, Akiko Yamashita, Shogo Takashiba, Fusanori Nishimura

    JOURNAL OF ENDOTOXIN RESEARCH   13 ( 4 )   227 - 234   2007年

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    記述言語:英語   出版者・発行元:SAGE PUBLICATIONS LTD  

    Diabetic subjects are susceptible to atherosclerosis. It has been postulated that inflammation plays a crucial role in atherogenesis. Since previous studies suggested persistent low-grade infection by Gram-negative bacteria such as Chlamydia spp. and/or periodontal infection is associated with increased atherogenesis among diabetic subjects, we hypothesized that macrophages under hyperglycemia respond to lipopolysaccharide (LPS) challenge in a more exaggerated manner than under normal glucose conditions. Therefore, we examined cytokine productivity and associated signal transduction molecules in LPS-stimulated the monocytic cell line THP-1, under conditions of hyperglycemia. Differentiated THP-1 cells were cultured under normal and high glucose conditions without fetal bovine serum, and were stimulated with Escherichia coli LPS in the presence of LPS binding protein. Following stimulation, activated signal transduction molecules were detected by protein rnicroarray and confirmed thereafter. Results indicated that c-jun N-terminal kinase (INK) was highly-phosphorylated at high glucose concentrations, and this was confirmed by Western-immunoblotting. Tumor necrosis factor-alpha and monocyte chemo-attractant protein-1 production were significantly enhanced under these conditions. SP600125, a selective inhibitor of JNK, dose-dependently suppressed the production of these cytokine. Therefore, we suggest that this may be one of the mechanisms by which sub-clinical infection by Gram-negative bacteria promotes atherosclerosis in diabetic subjects.

    DOI: 10.1177/0968051907082608

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  • Periodontal infection and dyslipidemia in type 2 diabetics: Association with increased HMG-CoA reductase expression

    F. Nishimura, A. Taniguchi, M. Yamaguchi-Morimoto, Y. Soga, Y. Iwamoto, S. Kokeguchi, A. Kuroe, M. Fukushima, Y. Nakai, Y. Seino

    HORMONE AND METABOLIC RESEARCH   38 ( 8 )   530 - 535   2006年8月

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    記述言語:英語   出版者・発行元:GEORG THIEME VERLAG KG  

    Recent studies have suggested that the periodontal disease, chronic sub-clinical inflammation, is associated with atherosclerosis, although "cause or effect" relationship is still unclear. The aim of this study was to assess the association between the degree of periodontal infection and lipid profiles in diabetic subjects. Additionally, the association of such sub-clinical inflammation with HMG-CoA reductase gene expression was evaluated. One hundred and thirty-one non-obese relatively well-controlled Japanese type 2 diabetic patients were enrolled for the study. Although no significant association was observed between serum triglycerides, HLD-cholesterol and antibody titer to Porphyromonas gingivalis (Pg), the most predominant periodontal pathogen in adults, LDL-cholesterol was significantly associated with antibody titer to Pg. Concomitantly, the same works out to be true for total cholesterol. To understand the possible mechanisms underlying this association, we evaluated 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase gene expression in cultured HepG2 cells stimulated by either bacterial lipopolysaccharide (LPS) or inflammatory cytokines. Although Pg and E. coli LPS had no effect on HMG-CoA reductase gene expression, both tumor necrosis factor-a and interleukin-6 (IL-6), especially IL-6 at low concentration, markedly up-regulated HMG-CoA reductase gene expression. It can be concluded that Pg infection is associated with increased LDL-cholesterol in diabetic subjects, which may be accompanied by increased cholesterol synthesis by inflammatory cytokines.

    DOI: 10.1055/s-2006-949525

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  • 造血器腫瘍を中心とした血液疾患患者における歯周病の重症度とPorphyromonas gingivalisに対する血清IgG抗体価との関連性に関する研究

    曽我賢彦, 岩本義博, 谷本一郎, 浅田薫, 横井彩, 目黒道生, 工藤値英子, 吉澤さゆり, 山部こころ, 外山裕, 園井教裕, 岩田宏隆, 岡田祐佳, 冨山高史, 新井英雄, 西村英紀, 高柴正悟

    日本歯科保存学雑誌   2006年

  • Thiazolidinedione (pioglitazone) blocks P. gingivalis- and F. nucleatum, but not E. coli, lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) production in adipocytes

    Yamaguchi M, Nishimura F, Naruishi H, Soga Y, Kokeguchi S, Takashiba S

    J Dent Res   2005年

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  • Periodontal disease as part of the insulin resistance syndrome in diabetic patients

    Nishimura F, Soga Y, Iwamoto Y, Kudo C, Murayama Y

    J Int Acad Periodontol   7 ( 1 )   16 - 20   2005年

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  • Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth

    Ogino M, Kido J, Bando M, Hayashi N, Wada C, Nagata T, Nishimura F, Soga Y, Takashiba S, Kubota T, Itagaki M, Shimada Y, Tai H, Yoshie H, Yamazaki N, Shinohara Y, Kataoka M

    J Dent Res   2005年

  • Monocytes of distinct clinical types of leprosy are differentially activated by cross-linking class II HLA molecules to secrete IL-12

    H Ohyama, N Kato, K Takeuchi, Y Soga, Y Uemura, F Nishimura, S Matsushita

    APMIS   112 ( 4-5 )   271 - 274   2004年4月

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    記述言語:英語   出版者・発行元:BLACKWELL MUNKSGAARD  

    Leprosy is characterized by a wide spectrum of clinical features depending on the individual differences in Th1-type immunity. The objective of this study was to evaluate whether monocyte activation by stimulus via class II HLA molecules would be correlated with the differences in cellular immune responses among diverse clinical forms of leprosy. IL-1beta and IL-12 productivity in monocyte preparations obtained from PBMCs was estimated in patients with lepromatous- and tuberculoid-type leprosy. We found that monocytes from lepromatous patients produced significantly higher (about 4-fold higher) amounts of IL-12 as compared to in patients with tuberculoid type of leprosy when class II HLA molecules were cross-linked with anti-HLA class II antibodies, whereas almost equal amounts of IL-1beta were produced from each monocyte preparation by stimulus via class II HLA molecules regardless of the clinical form of leprosy. These results suggest that monocyte activation differs between lepromatous and tuberculoid patients in terms of IL-12 secretion, which might be related to individual differences in the cellular immune responses according to the clinical type of leprosy.

    DOI: 10.1111/j.1600-0463.2004.apm11204-0507.x

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  • Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients: Relationship with C-reactive protein and albuminuria

    A Kuroe, A Taniguchi, A Sekiguchi, M Ogura, Y Murayama, F Nishimura, Y Iwamoto, Y Seino, S Nagasaka, M Fukushima, Y Soga, Y Nakai

    HORMONE AND METABOLIC RESEARCH   36 ( 2 )   116 - 118   2004年2月

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    記述言語:英語   出版者・発行元:GEORG THIEME VERLAG KG  

    The aim of the present study was to investigate the relationship between periodontal bacteria infection (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Prevotella intermedius) and C-reactive protein (CRP) and albuminuria in non-obese Japanese type 2 diabetic patients. One hundred and thirty-four non-obese Japanese type 2 diabetic patients without evidence of current acute illness including clinically significant acute infectious disease were enrolled into the study. The degree of periodontal bacterial infection was evaluated using IgG titer against Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, or Prevotella intermedius. The bacterial sonic extracts were used as antigens. High-sensitivity CRP (hCRP), glucose, glycosylated hemoglobin (HbA(1c)), and lipids were also measured after an overnight fast. Urinary albumin excretion rate as a ratio of urinary albumin and urinary creatinine was assessed in a morning spot urine sample using a commercial enzymatic immunoassay. The prevalence of Porphyromonas gingivalis infection was 52.2 % and that of Actinobacillus actinomycetemcomitans and Prevotella intermedius was 7.5 and 14.2 %, respectively. IgG titer against Porphyromonas gingivalis significantly correlated with CRP (r = 0.225, p < 0.001) and albuminuria (r = 0.185, p < 0.05), while IgG titer against Actinobacillus actinomycetemcomitans or Prevotella intermedius was not associated with either parameter. These results suggest that among periodontal bacteria, Porphyromonas gingivalis infection is associated with atherosclerosis in non-obese Japanese type 2 diabetic patients.

    DOI: 10.1055/s-2004-814221

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  • CYP2C polymorphisms, phenytoin metabolism and gingival overgrowth in epileptic subjects

    Y Soga, F Nishimura, Y Ohtsuka, H Araki, Y Iwamoto, H Naruishi, N Shiomi, Y Kobayashi, S Takashiba, K Shimizu, Y Gomita, E Oka

    LIFE SCIENCES   74 ( 7 )   827 - 834   2004年1月

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    記述言語:英語   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Previous studies suggested that the onset of phenytoin-induced gingival overgrowth depended on serum phenytoin concentration. Cytochrome P450 2C (CYP2C) plays an important role in phenytoin metabolism. Recently, single nucleotide polymorphisms in the coding region of CYP 2C influencing phenytoin metabolism were identified. The purpose of the present study was to see if CYP 2C polymorphisms might relate to the onset and severity of phenytoin-induced gingival overgrowth. Twenty-eight epileptic patients taking phenytoin aged 15 to 75 (mean age: 42.2 years old, 20 males and 8 females) and 56 unrelated healthy subjects aged 30 to 48 (mean age: 36.8 years old, 48 males and 8 females) were examined for CYP 2C polymorphisms. All epileptic subjects were examined for the degree of gingival overgrowth, daily phenytoin dose and serum phenytoin concentration. The results indicated about 7% of the subjects including epileptic and healthy subjects examined were positive for CYP 2C9*3. However, the degree of gingival overgrowth did not directly correlate with CYP 2C polymorphisms. Nevertheless, the subjects with severer gingival overgrowth exhibited significantly higher serum phenytoin concentration, indicating that phenytoin metabolism is an important determinant for the severity of the disease. Additionally, CYP 2C9*3 carriers exhibited significantly higher serum drug concentration to drug dose. Therefore, we concluded although the gene analysis is not directly related to diagnose the disease itself, it can be utilized in estimating serum phenytoin concentration from drug dose, which in turn serves to predict the future development and clinical course of the disease. (C) 2003 Elsevier Inc. All rights reserved.

    DOI: 10.1016/j.lfs.2003.07.018

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  • Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis

    Y Iwamoto, F Nishimura, Y Soga, K Takeuchi, M Kurihara, S Takashiba, Y Murayama

    JOURNAL OF PERIODONTOLOGY   74 ( 8 )   1231 - 1236   2003年8月

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    記述言語:英語   出版者・発行元:AMER ACAD PERIODONTOLOGY  

    Background: Elevated levels of C-reactive protein (CRP) and decreased plasma adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent observations suggested that adiponectin and tumor necrosis factor-alpha (TNF-alpha) suppressed each other's production. Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-a levels.
    Methods: Fifteen chronic periodontitis patients with various systemic conditions at high risk for atherosclerosis were enrolled in the study. Patients were non-surgically treated with topical application of antibiotics and mechanical debridement of calculus once a week for 1 month. Before and after therapy, CRP, adiponectin, and TNF-alpha levels were measured.
    Results: Both CRP and TNF-alpha levels were significantly decreased after treatment (P <0.01 and P <0.03, respectively), while adiponectin levels did not change significantly.
    Conclusions: Periodontal treatment is effective in reducing CRP and TNF-alpha, while adiponectin does not appear to be influenced by periodontal treatment. Elevated levels of CRP and TNF-alpha may be associated with increased risk for future development of atherosclerosis in periodontitis patients.

    DOI: 10.1902/jop.2003.74.8.1231

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  • Tumor necrosis factor-alpha gene (TNF-alpha)-1031/-863,-857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese

    Y Soga, F Nishimura, H Ohyama, H Maeda, S Takashiba, Y Murayama

    JOURNAL OF CLINICAL PERIODONTOLOGY   30 ( 6 )   524 - 531   2003年6月

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    記述言語:英語   出版者・発行元:BLACKWELL MUNKSGAARD  

    Objectives: Tumour necrosis factor-alpha (TNF-alpha ) and interleukin-1beta (IL-1beta ) participate in the establishment of inflammatory lesions in periodontitis. High production of these cytokines may relate to the severity of periodontitis. There have already been several studies examining the association between periodontitis and single nucleotide polymorphisms (SNPs) that affect cytokine productivity. Recently, new SNPs of TNF-alpha , -1031, -863 and -857, variants of which are observed in a relatively large proportion in Japanese, have been identified. The variant alleles of these SNPs have been suggested to be related to high TNF-alpha production. For a better understanding of the genetic factors associated with the severity of periodontitis, further analysis including these newly identified SNPs is essential. In addition, previous reports on TNF-alpha or IL-1beta SNPs associated with periodontitis were mainly for Caucasian populations. Therefore, the aim of this study is to examine the association between severe periodontitis in Japanese and the following SNPs: five in the TNF-alpha gene promoter (-1031, -863, -857, -308, -238) and three in the IL-1beta gene (-511, -31, +3953).
    Material and Methods: A total of 128 Japanese individuals were enrolled in this study. They were 64 patients with severe adult periodontitis and 64 healthy subjects. TNF-alpha and IL-1beta SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism for all subjects. TNF-alpha and IL-1beta production from LPS-stimulated monocytes/macrophages was also measured for 15 healthy male subjects.
    Results: TNF-alpha production in TNF-alpha -1031/-863 (linkage disequilibrated) or -857 SNP variant allele carriers tended to be elevated, and the frequency of subjects who carried at least one variant allele in TNF-alpha -1031, -863 or -857 SNPs among severe periodontitis patients was significantly higher than in healthy subjects.
    Conclusion: Since the frequency of subjects who carried at least one variant allele in TNF-alpha -1031, -863 or -857 SNPs was higher in periodontitis patients than in healthy subjects, TNF-alpha -1031, -863 and -857 SNPs appear to be associated with severe adult periodontitis in Japanese populations.

    DOI: 10.1034/j.1600-051X.2003.00287.x

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  • Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients

    A Taniguchi, F Nishimura, Y Murayama, S Nagasaka, M Fukushima, M Sakai, S Yoshii, A Kuroe, H Suzuki, Y Iwamoto, Y Soga, T Okumura, M Ogura, Y Yamada, Y Seino, Y Nakai

    METABOLISM-CLINICAL AND EXPERIMENTAL   52 ( 2 )   142 - 145   2003年2月

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    記述言語:英語   出版者・発行元:W B SAUNDERS CO  

    The aim of the present study was to investigate whether non-obese Japanese type 2 diabetic patients with porphyromonas gingivalis infection have atherosclerotic vascular diseases. A total of 134 non-obese Japanese type 2 diabetic patients (96 men and 38 women, aged 36 to 84 years, body mass index [BMI] 20.1 to 26.9 kg/m(2)) were studied. In conjunction with BMI, glycosylated hemoglobin (HbA(1c)), fasting glucose, and serum lipids (triglycerides, total cholesterol, high-density lipoprotein [HDL] cholesterol, low-density lipoprotein [LDL] cholesterol) were measured. LDL cholesterol was calculated using the Friedewald formula. Using high-resolution B-mode ultrasound scan, we measured intimal medial thickness (IMT) in plaque-free segments of bilateral common carotid arteries, and the mean of IMT in 2 vessels was used for the analysis. Furthermore, we calculated the degree of stenosis in plaque segments of bilateral common carotid arteries. The degree of carotid atherosclerosis was expressed as a percentage ratio between the area of plaque and that of the lumen using the formula (Lumen Area Residual - Lumen Area)/Lumem Area x 100. Both the areas were automatically measured by the system on a frozen transverse scanning plane at the site of maximal narrowing. When 2 or more plaques were present in the vessel, only that causing the greatest degree of stenosis was considered for analysis. Values represent mean+/-SEM unless otherwise stated. Immunoglobulin G (IgG) titer against porphyromonas gingivalis was 245 +/- 65 (mean +/- 2 SD) in nondiabetic healthy subjects. In contrast, there was a wide variation in IgG titer against porphyromonas gingivalis in type 2 diabetic patients studied (range, 16 to 26,800). Thus, we classified our type 2 diabetic patients into 2 subpopulations according to the value of mean +/- 2 SD (= 310) of nondiabetic healthy subjects: one with high IgG titer against porphyromonas gingivalis (>310) (1,422 :t 408) and the other with normal IgG titer against porphyromonas gingivalis (<310) (152 +/- 10, P = .002). The populations did not differ with respect to age, sex, BMI, fasting glucose, HbA(1c) serum triglycerides, total, HDL, and LDL cholesterol levels. Although the mean IMT in plaque-free segments was not different between the 2 groups (0.73 +/-0.03 v 0.68 +/- 0.02 mm, P = .098), the degree of stenosis in plaque segments was significantly higher in the high IgG titer group (12.0% +/- 2.2%) than in normal one (5.5% +/- 1.4%, P = .009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients. Copyright 2003, Elsevier Science (USA). All rights reserved.

    DOI: 10.1053/meta.2003.50001

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  • Periodontal disease and diabetes mellitus: The role of tumor necrosis factor-alpha in a 2-way relationship

    F Nishimura, Y Iwamoto, J Mineshiba, A Shimizu, Y Soga, Y Murayama

    JOURNAL OF PERIODONTOLOGY   74 ( 1 )   97 - 102   2003年1月

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    記述言語:英語   出版者・発行元:AMER ACAD PERIODONTOLOGY  

    It is generally accepted that obesity is associated with many other multiple-risk factor syndromes such as hypertension, hyperlipidemia, type 2 diabetes mellitus, and periodontal disease. The number of obese people is increasing rapidly in both western and eastern countries. Adipocytes in the adipose tissues of obese people produce large quantities of biologically active molecules such as leptin, an important molecule regulating energy expenditure and body weight. Therefore, adipocyte-derived active molecules, named adipocytokines, are candidate molecules accounting for the close association between obesity and other multiple-risk factor syndromes. The proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) is produced by adipocytes, and its blood concentration is elevated in obese patients and declines with weight loss. Studies have demonstrated that TNF-alpha. suppresses insulin action via its specific receptor; hence, it exacerbates insulin resistance. In addition to adipocytes, monocytes/macrophages produce large quantities of TNF-alpha. Thus, TNF-alpha, produced from monocytic cells due to inflammatory diseases, may have an additive influence on insulin sensitivity to adipocyte-derived TNF-alpha. Here, we hypothesized that 1) TNF-alpha produced by the adipose tissues of obese patients acts as a risk factor for periodontal inflammation, and 2) TNF-alpha produced due to periodontal inflammation may be an additional important factor influencing insulin sensitivity in both obese and type 2 diabetic patients. We believe that this interaction is a possible mechanism accounting for a 2-way relationship between type 2 diabetes and periodontal disease.

    DOI: 10.1902/jop.2003.74.1.97

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  • 歯周治療により炎症マーカーが改善したと考察された重度歯周炎を伴うリウマチ患者の症例報告

    工藤値英子, 河野隆幸, 西村英紀, 大山秀樹, 明貝文夫, 成石浩司, 岩本義博, 高橋直樹, 曽我賢彦, 新井英雄, 村山洋二, 高柴正悟

    日本歯科保存学雑誌   46 ( 1 )   110 - 117   2003年

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  • TNF-aおよびIL-1b遺伝子の一塩基多型の研究 -日本人歯周炎の重症化との関連性-

    曽我賢彦

    岡山歯学会雑誌   21 ( 1 )   83 - 91   2002年

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  • Porphyromonas gingivalis infection is associated with elevated C-reactive protein in nonobese Japanese type 2 diabetic subjects

    Nishimura F, Taniguchi A, Iwamoto Y, Soga Y, Fukushima M, Nagasaka S, Nakai Y, Murayama Y

    Diabetes Care   25 ( 10 )   1888   2002年

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▼全件表示

講演・口頭発表等

  • 食道癌DCF療法開始前からの口腔衛生管理による口腔粘膜炎予防の有効性

    日本歯科衛生学会第12回学術大会  2017年 

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  • 歯科医療職としての誇りをもって患者の尊厳を守る―造血細胞移植を受けたがんサバイバーから学ぶこと―

    日本がん口腔支持療法学会 第3回学術集会  2017年 

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  • 大学病院の医療現場を利用した「高度医療支援・周術期口腔機能管理実習」報告

    文部科学省課題解決型高度医療人材養成プログラム選定事業 健康長寿社会を担う歯科医学教育改革ー死生学や地域包括ケアモデルを導入した医科歯科連携教育体制の構築ー 平成29年度連携シンポジウム  2017年 

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  • e-learningシステムの今後の有効活用に向けて

    文部科学省課題解決型高度医療人材養成プログラム選定事業 健康長寿社会を担う歯科医学教育改革ー死生学や地域包括ケアモデルを導入した医科歯科連携教育体制の構築ー 平成29年度連携シンポジウム  2017年 

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  • 初回外来化学療法患者の口腔カンジダ感染量が口腔内の疼痛やQOLに及ぼす影響

    日本歯科衛生学会第12回学術大会  2017年 

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  • 岡山大学病院のチーム医療現場を利用した緩和ケア教育の取り組み

    第36回日本歯科医学教育学会総会および学術大会  2017年 

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  • 口腔衛生管理はなぜ必要か?―口腔内細菌叢および抗菌薬耐性の見地から

    第15回日本臨床腫瘍学会学術大会  2017年 

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  • がん口腔支持療法の担い手の養成―歯学生および研修歯科医を対象としたカリキュラム構築の試みー

    第15回日本臨床腫瘍学会学術大会  2017年 

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  • Replacing zoledronic acid with denosumab increase the risk of ONJ

    MASCC/ISOO 2017 Annual Meeting  2017年 

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  • 周術期患者に対して歯科的治療の意思決定支援を行った一症例

    日本歯科衛生学会第12回学術大会  2017年 

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  • 急性期医療の現場でチーム医療を体験させる多職種連携教育の教育効果

    第36回日本歯科医学教育学会総会および学術大会  2017年 

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  • 周術期患者に対して歯科的治療の意志決定支援を行った一症例

    日本がん口腔支持療法学会 第3回学術集会  2017年 

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  • 定期歯科受診は手術前の歯科治療の必要性を減ずる

    日本がん口腔支持療法学会 第3回学術集会  2017年 

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  • 歯学部新入生を対象としたグループワークが終末期医療への態度意識に与えた影響

    日本がん口腔支持療法学会 第3回学術集会  2017年 

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  • 食道癌DCF療法開始前からの口腔衛生管理による口腔粘膜炎予防の有効性

    日本がん口腔支持療法学会 第3回学術集会  2017年 

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  • 手術実施病院の周術期口腔管理を行う歯科医療者に求められる素養の考察

    日本がん口腔支持療法学会 第3回学術集会  2017年 

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  • The necessity of a systematic curriculum on end-of-life care

    2017 IADR/AADR/CADR General Session & Exhibition  2017年 

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  • ゾレドロン酸からデノスマブへの投与変更はARONJのリスク因子である

    第71回 NPO法人日本口腔科学会学術集会  2017年 

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  • Replacing zoledronic acid with denosumab increases the risk of ONJ

    2017 IADR/AADR/CADR General Session & Exhibition  2017年 

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  • e-learningシステムの概要と岡山大学における運用方法について

    文部科学省課題解決型高度医療人材養成プログラム選定事業 健康長寿社会を担う歯科医学教育改革ー死生学や地域包括ケアモデルを導入した医科歯科連携教育体制の構築ー 平成28年度連携シンポジウム  2016年 

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  • 歯学部1年次生を対象とした終末期医療に関する一講義が学生の態度意識に及ぼした影響

    日本がん口腔支持療法学会 第2会学術集会  2016年 

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  • 多職種連携の基本的な能力及び姿勢を育む演習の構築一大学病院の医療現場を利用した演習の教育効果の検討と今後の課題ー

    文部科学省課題解決型高度医療人材養成プログラム選定事業 健康長寿社会を担う歯科医学教育改革ー死生学や地域包括ケアモデルを導入した医科歯科連携教育体制の構築ー 平成28年度連携シンポジウム  2016年 

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  • 岡山大学病院口腔外科(病態系)において医療支援歯科治療部を介して医科歯科連携を行った口腔外科疾患の調査

    第37回 岡山歯学会総会・学術集会  2016年 

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  • 「MASCC/ISOO がん治療に伴う粘膜障害に対するエビデンスに基づいた臨床診療ガイドライン」について

    第26回日本口腔内科学会/第29回日本口腔診断学会 合同学術大会  2016年 

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  • 歯科衛生士による専門的口腔衛生指導が食道がん術後肺炎予防に及ぼす効果

    日本歯科衛生学会 第11回学術大会  2016年 

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  • 造血幹細胞移植患者へのグリコペプチド系抗菌薬投与と口腔粘膜上細菌叢の変化

    日本がん口腔支持療法学会 第2固学術集会  2016年 

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  • 病院医療に歯科の専門性はどう役立つか?

    第9回 日本総合歯科学会総会・学術大会  2016年 

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  • 岡山大学における在宅・訪問歯科診療実習の実績報告

    第35回日本歯科医学教育学会総会および学術大会  2016年 

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  • 造血細胞移植患者の咽頭痛の発生状況および粘膜障害との関連について

    第38回日本造血細胞移植学会総会  2016年 

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  • 造血幹細胞移植期間中に下唇に発症した深在性真菌症に対する多職種連携による対応と経過―歯科衛生士の立場から

    第38回日本造血細胞移植学会総会  2016年 

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  • 造血幹細胞移植におけるチーム医療―口腔ケア:歯科医の立場から

    第38回日本造血細胞移植学会総会  2016年 

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  • 造血幹細胞移植後に起こる口腔粘膜上細菌叢の変化―PCR-DGGE 法を用いた解析

    第38回日本造血細胞移植学会総会  2016年 

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  • 地域かかりつけ歯科と某腫瘍センターの連携における歯科衛生士によるがん支持療法

    日本歯科衛生学会 第11回学術大会  2016年 

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  • 「MASCC/ISOO がん治療に伴う粘膜障害に対する工ビデンスに基づいた臨床診療ガイドライン」の策定過程と概要

    第14回日本臨床腫瘍学会学術大会  2016年 

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  • 食道外科患者の口腔内の特徴 呼吸器外科、婦人科、乳腺外科、脳外科患者との比較

    日本食道学会学術集会  2016年 

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  • 5年次歯学生を対象とした周術期チーム医療の現場を体験させる演習が多職種連携の認識に及ぼした影響

    第35回日本歯科医学教育学会総会および学術大会  2016年 

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  • Bacterial substitution on the oral mucosa before and after hematopoietic cell transplantation: gene-level analysis by PCR-denaturing gradient gel electrophoresis

    MASCC/ISOO 2016 Annual Meeting  2016年 

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  • 病院医療における口腔内管理のニーズとそれへの対応の実際

    第 7 回 愛媛口腔ケア研究会  2016年 

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  • がん治療に伴う粘膜障害対策の国際的な潮流-MASCC/ISOO粘膜障害対策ガイドライン2013年改訂版

    日本がん口腔支持療法学会 第1回学術大会  2016年 

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  • 食道癌患者の口腔感染管理と咬合回復が周術期の体重変化に影響した可能性のある一症例

    日本食道学会学術集会  2016年 

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  • 在宅歯科医療に対する歯科研修医の意識調査

    第35回日本歯科医学教育学会総会および学術大会  2016年 

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  • 1年次歯学生を対象とした終末期を含めた緩和医療に関する講義がターミナルケア態度に及ぼした影響

    第35回日本歯科医学教育学会総会および学術大会  2016年 

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  • Importance of dental intervention as risk management in patients with severe dementia

    The 10th International Association of Gerontology and Geriatrics (IAGG) Asia / Oceania Congress of Gerontology and Geriatrics 2015 Congress  2015年 

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  • Oral infection in the cancer patient: antimicrobial resistance (2015 MASCC CE course)

    MASCC/ISOO 2015 Annual Meeting  2015年 

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  • 再発/難治性の非ホジキンリンパ腫への自家末梢血造血幹細胞移植の前処置に、Gemcitanbine、Busulfan、Melphalan を使用した10 例

    第37回日本造血細胞移植学会総会  2015年 

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  • Autologous Stem-Cell Transplantation with High-Dose Infusional Gemcitabine, Busulfan and Melphalan for Relapse/Refractory Non-Hodjikin's Lymphoma

    The 37th Annual Meeting of the Japan Society for Hematopoietic Cell Transplantation  2015年 

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  • 造血細胞移植前後の口腔粘膜上細菌叢の変化

    第15回 Okayama Hematology Conference  2015年 

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  • Advancing Hospital Medicine with Dentistry: Activities of Dental Staff, IncludingDental Hygienists, at Okayama University Hospital

    2015 5th Research Week-International Symposium of College of Oral Medicine - Outcomes Research and Translational Medicine in Oral Health Care  2015年 

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  • 病院医療における口腔感染管理の意義と実際

    第85回日本感染症学会西日本地方会学術集会,第58回日本感染症学会中日本地方会学術集会,第63回日本化学療法学会西日本支部総会合同開催  2015年 

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  • 岡山大学病院歯科医師臨床研修における多職種連携診療及び在宅歯科医療研修の現状

    第34回日本歯科医学教育学会総会および学術大会  2015年 

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  • 大学病院を利用した高度医療支援・周術期回腔機能管理実習による緩和ケア教育の効果と課題

    第34回日本歯科医学教育学会総会および学術大会  2015年 

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  • 岡山大学における臨床講師を利用した在宅介護・訪問歯科診療参加型学外臨床実習について

    第34回日本歯科医学教育学会総会および学術大会  2015年 

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  • Bacterial Substitution on the Oral Mucosa before and after Hematopoietic Cell Transplantation: Gene-level Analysis by PCR-denaturing Gradient Gel Electrophoresis

    The 20th annual Congress of Asia-Pacific Blood and Marrow Transplantation Group in Okinawa  2015年 

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  • Patinents who undergo esophageal surgery require more dental treatment than who undergo Cranial nerve surgery, Respiratory Surgery, Gynecological surgery, Brest thyroid surgery

    The 63rd Annual Meeting of Japanese Association for Dental Research  2015年 

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  • 周術期等における口腔内管理の意義と実際

    津山歯科医師会学術講演会  2014年 

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  • 病院医療における口腔感染管理の意義と実際

    第179回ICD講習会  2014年 

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  • 医療連係の場を利用した医療人育成を目的とする歯学教育の推進

    第2回高度医療を支える歯科医療を具体的に考えるシンポジウム  2014年 

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  • Completion of the Japanese translation of the MASCC/ISOO Mucositis Guidelines

    2014 MASCC/ISOO INTERNATIONAL SYMPOSIUM ON SUPPORTIVE CARE IN CANCER  2014年 

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  • 大腸癌化学療法症例における口腔管理の実態の検討

    第100回日本消化器病学会総会  2014年 

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  • がん支持療法の一翼を担う歯周病治療

    日本歯周病学会第3回四国地区臨床研修会  2014年 

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  • 地域医療を担い得る医療人育成を目指した歯学教育の推進

    NPO在宅ケアを支える診療所・市民全国ネットワーク 第20回全国の集いin岡山2014  2014年 

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  • 歯科衛生士が関わるがん治療患者の口腔衛生管理の実際とがん患者の高齢化に向けた今後の課題

    日本歯科衛生学会 第9回学術大会  2014年 

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  • 造血幹細胞移植期における口腔衛生管理中に下口唇の深在性皮膚真菌症を併発した白血病患者の一症例

    第7回 日本口腔検査学会総会・学術大会  2014年 

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  • 大腸癌全身化学療法症例における周術期口腔管理の現状

    第12回日本臨床腫瘍学会学術集会  2014年 

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  • 岡山大学医学部1年次生に対する歯学部早期体験実習の試み

    第33回日本歯科医学教育学会総会および学術大会  2014年 

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  • 慢性歯周炎に罹患した生体腎移植患者の周術期口腔感染管理を病病連携で行った症例

    第57回秋季日本歯周病学会学術大会  2014年 

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  • 周術期管理チーム医療研修が研修歯科医に与えた影響

    第32回日本歯科医学教育学会総会・学術大会  2013年 

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  • 周術期の口腔機能管理の意義と実際

    日本老年歯科医学会 第24回学術大会  2013年 

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  • 周術期の栄養管理に歯科の専門性はどう役立つか?

    第7回周術期栄養療法研究会  2013年 

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  • 造血幹細胞移植後の口腔粘膜障害好発時期における口腔粘膜上細菌の抗生剤感受性

    第35回日本造血細胞移植学会総会  2013年 

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  • Risk factors for oral mucositis in patients after hematopoietic stem cell transplantation under intensive oral care

    2013 Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO) Annual Meeting  2013年 

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  • Successful supports resulted in improving nutritional condition of a neuroleptic malignant syndrome patient by dental intervention -A case report

    The 20th IAGG World Congress of Gerontology and Geriatrics  2013年 

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  • 周術期の口腔機能管理の実施体制 病院医療における口腔内管理の意義と実際 岡山大学病院を例として

    第10回日本口腔ケア学会総会・学術大会  2013年 

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  • 生体腎移植患者の周術期口腔感染管理を病病連携にて行った1例

    第39回尾三因医学会  2013年 

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  • Advancing Hospital Medicine with Dentistry - Research and Education in Okayama University Hospital -

    第3回 岡山医療教育研究国際シンポジウム  2013年 

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  • 某大学病院の外来通院がん治療患者における口腔管理の実態と今後の課題について

    日本歯科衛生学会第8回学術大会  2013年 

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  • 今後求められる地域医療を担い得る医療人育成を目指した歯学教育の推進

    平成25年度文部科学省 先導的大学改革推進委託事業 医療提供体制見直しに対応する医療系教育実施のためのマネジメントの在り方に関する調査研究 医学・看護学・歯学チーム合同シンポジウム  2013年 

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  • 食道癌患者のより良い周術期医療のために歯科はどのような貢献ができるのか?~周術期管理センター(PERIO)歯科部門の取り組み~

    第75回日本臨床外科学会総会  2013年 

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  • 造血細胞移植による口腔粘膜障害のハイリスク因子の検討

    第34回日本造血細胞移植学会総会  2012年 

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  • 慢性歯周炎および全身疾患関連歯周炎・白血病を併発した患者に対する歯周治療の一例

    第55回秋季日本歯周病学会学術大会  2012年 

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  • 岡山大学病院の周術期口腔機能管理の具体的な内容

    周術期における口腔機能管理を具体的に考えるシンポジウム  2012年 

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  • 歯科医師臨床研修におけるチーム医療教育

    第31回日本歯科医学教育学会総会および学術大会  2012年 

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  • 多職種連携医療をいかに教育するか―臨床研修における多職種連携教育の実践例

    第31回日本歯科医学教育学会総会および学術大会  2012年 

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  • 口腔粘膜上細菌と心内膜炎原因菌の同一性を遺伝子レベルで検討した一症例

    第137回日本歯科保存学会2012年度秋季学術大会  2012年 

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  • がん治療患者における歯科医療;歯科衛生士の観点から求められるもの

    第22回日本歯科医学会総会  2012年 

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  • 特定機能病院における医科歯科連携の中で果たす歯科医療の役割

    第22回日本歯科医学会総会  2012年 

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  • 岡山大学病院における「歯科技工士の医療連携について」

    第14回日本口腔顔面技工研究会  2012年 

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  • 医療連携担当歯科衛生士としての活動報告

    日本歯周病学会 第7回中国地区臨床研修会  2012年 

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  • Prevalence of mecA on oral mucosa in patients undergoing hematopoietic stem cell transplantation

    Multinational Association of Supportive Care in Cancer/ International Society of Oral Oncology 2012 International Symposium  2012年 

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  • 岡山大学病院腫瘍センターにおけるビスフォスフォネート使用患者に対する当科の取り組み

    第66回NPO法人日本口腔科学会学術集会  2012年 

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  • 医療連携担当歯科衛生士としての活動

    第33回岡山歯学会総会・学術大会  2012年 

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  • 「チーム医療研修プログラム」の意義の検討

    第33回岡山歯学会総会・学術大会  2012年 

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  • 岡山大学病院歯科系が医科系から受けた院内紹介とそれに対する初動対応―平成22年度を対象とした実態調査―

    第33回岡山歯学会総会・学術大会  2012年 

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  • 周術期医療に歯科の専門性はどう役立つか?

    第33回岡山歯学会総会・学術大会  2012年 

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  • Eosinophil Cationic Protein enhances the formation of stress fibers and production of TIMP-1 in human gingival fibroblasts

    第5回 高度医療都市を創出する未来技術国際シンポジウム  2012年 

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  • 造血幹細胞移植における口腔ケアチームの取り組み―歯科の立場から

    第33回日本造血細胞移植学会総会  2011年 

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  • 医歯看連携による組織的な口腔内管理造血細胞移植患者の口腔粘膜障害を減少させる

    第33回日本造血細胞移植学会総会  2011年 

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  • Eosinophil Cationic Protein Enhances the Growth of Human Gingival Fibroblasts

    第4回 高度医療都市を創出する未来技術国際シンポジウム  2011年 

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  • マウスピース型プロテクターによる気管内挿管時の歯牙損傷予防

    日本臨床麻酔学会第31回大会  2011年 

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  • 多職種協働による口腔ケアがもたらす臨床効果の実態調査

    日本歯科衛生学会第6回学術大会  2011年 

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  • 某大学病院腫瘍センターにおけるゾレドロネート(BP)投与患者の口腔に関する調査

    日本歯科衛生学会第6回学術大会  2011年 

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  • 岡山大学病院における歯科研修医を対象とした医療支援歯科研修プログラム

    第4回総合歯科協議会学術大会  2011年 

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  • 歯科研修医に対する周術期管理チーム医療教育の意義

    第32回岡山歯学会総会・学術集会  2011年 

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  • 血液疾患患者の移植検討期における歯周病感染度検査の実用化のための課題

    第4回日本口腔検査学会総会・学術大会  2011年 

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  • 白血病等の血液悪性疾患患者を対象とした口腔粘膜上における抗菌薬耐性遺伝子の保有状況の調査

    第4回日本口腔検査学会総会・学術大会  2011年 

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  • Antibiotics sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation

    Multinational Association of Supportive Care in Cancer/ International Society of Oral Oncology 2011 International Symposium  2011年 

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  • Loop-mediated isothermal amplification(LAMP)法によるバンコマイシン耐性遺伝子(vanA、vanB)検出法の確立

    第31回岡山歯学会総会・学術大会  2010年 

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  • 周術期管理センター(歯科部門)のニーズと現況について 経口気管挿管時に起こる歯の損傷とその対応

    第37回日本集中治療医学会学術集会  2010年 

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  • 造血幹細胞移植における口腔ケア―エビデンスに基づいたその意義と実際―

    第32回日本造血細胞移植学会総会・看護教育セミナー  2010年 

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  • 口腔粘膜障害に抗葉酸代謝拮抗剤(ロイコボリン)を軟膏様にして使用した一症例

    第32回日本造血細胞移植学会総会  2010年 

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  • チーム医療での医療情報活用のベースとしての電子カルテシステムの改良―既診療部門で行ったチーム医療活動についての時系列での「見える化」への工夫

    平成21年度大学病院情報マネジメント部門連絡会議  2010年 

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  • 病院医療支援を目的とした口腔の管理学および専門診療分野の必要性

    第24回日本顎頭蓋機能学会学術大会  2010年 

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  • 岡山大学病院腫瘍センターにおける歯科衛生士の活動 外来がん化学療法患者への取り組み

    第31回岡山歯学会総会・学術大会  2010年 

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  • 周術期における歯科介入の重要性 岡山大学病院周術期管理センター歯科部門の取り組み

    第7回日本口腔ケア学会総会・学術大会  2010年 

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  • Eosinophil Cationic Protein Enhances the Growth of Human Gingival Fibroblasts

    58th Annual Meeting, Japanese Association for Dental Research  2010年 

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  • 今後求められる歯科衛生士像とは?

    第31回岡山歯学会総会・学術大会  2010年 

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  • 病院医療を支援する歯科医療体制の構築を目指して

    第31回岡山歯学会総会・学術大会  2010年 

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  • Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation

    Multinational Association of Supportive Care in Cancer/ International Society of Oral Oncology 2010 International Symposium  2010年 

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  • 脂肪細胞はマクロファージと共存することでLPS刺激によって急性期タンパクSAAを高産生する

    第53回日本糖尿病学会年次学術集会  2010年 

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  • 脂肪細胞はマクロファージと共存することでLPS刺激によって急性期タンパクSAAを高産生する

    第52回秋季日本歯周病学会学術大会  2009年 

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  • 岡山大学病院周術期管理センター受診患者における手術前プラークフリーの実施状況

    日本歯科衛生学会 第4回学術大会  2009年 

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  • 岡山大学病院小児科で造血幹細胞移植を実施した患者の口腔粘膜障害と口腔内痛の実態について

    第4回日本歯科衛生学会学術大会  2009年 

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  • 肥満が摂食嚥下器官に及ぼす影響 咽頭狭窄が原因と考えられた摂食嚥下障害1症例による検討

    第15回日本摂食・嚥下リハビリテーション学会学術大会  2009年 

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  • 岡山大学病院周術期管理センター(歯科部門)設立後5ヶ月間の活動内容および今後の展開

    日本プライマリケア学会第16回岡山支部学術大会  2009年 

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  • Eosinophil Cationic Proteinがヒト歯肉線維芽細胞の増殖活性に及ぼす影響

    第2回 高度医療都市を創出する未来技術国際シンポジウム  2009年 

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  • マクロファージと共存する脂肪細胞はLPS刺激によってtoll-like receptorを介するシグナルを増強する分子群を産生する

    第52回日本糖尿病学会学術大会  2009年 

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  • ハンセン病後遺症を有する患者の口腔感染管理に対する歯科衛生士を中心としたチームアプローチ

    第52回日本歯周病学会春季学術大会  2009年 

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  • 造血幹細胞移植直前から生着までの期間における口腔粘膜上細菌の変化の調査および血液から検出される細菌との比較検討

    第31回日本造血細胞移植学会総会  2009年 

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  • 周術期における歯科介入の重要性 岡山大学病院周術期管理センター歯科部門の取り組み

    第6回 日本口腔ケア学会総会・学術大会  2009年 

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  • 岡山大学病院周術期管理センター(歯科部門)設立後約1年間の活動内容および今後の課題

    第30回岡山歯学会総会・学術大会  2009年 

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  • 歯周病治療を通じて、2型糖尿病患者の行動変容を促した一症例

    日本糖尿病合併症学会  2009年 

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  • 歯肉増殖をMyeloperoxidaseおよびCD68免疫染色で単球性白血病によるものと証明した一症例

    第2回日本口腔検査学会総会・学術大会  2009年 

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  • molecular analysis of transition of oral bacterial flora in patients receiving bone marrow transplantation

    第2回日本口腔検査学会総会・学術大会  2009年 

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  • 歯科の生き残りではなくさらなる発展を目指して―がん・周術期の病院医療という見過ごされていた「夢(?)舞台」―

    平成21年度(社)日本補綴歯科学会関西支部,中国・四国支部総会ならびに合同学術大会  2009年 

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  • 模擬患者参加型の医療面接を組み合わせたテュートリアル教育の試み

    第29回岡山歯学会総会・学術大会  2008年 

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  • 急性骨髄性白血病の歯周病治療における歯周病細菌の血清IgG抗体価および細菌DNA検査の応用例

    第1回日本口腔検査学会総会・学術大会  2008年 

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  • Cytokine Profile Produced from LPS-stimulated Mcrophage-Adipocyte Co-cultures

    86th International Association for Dental Research  2008年 

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  • Oral Bacterial Microflora Changes in Patients Receiving Bone Marrow Transplantation

    86th International Association for Dental Research  2008年 

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  • 低濃度LPS刺激条件下の脂肪細胞・マクロファージ共培養系における脂肪細胞の網羅的遺伝子発現解析

    第51回日本糖尿病学会年次学術集会  2008年 

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  • 嚥下障害に対して多職種の連携のもと対応した症例―向精神薬を長期間服用していた患者の嚥下障害に対する病態の考察―

    日本歯科衛生学会第3回学術大会  2008年 

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  • Stevens-Johnson症候群の患者の口腔粘膜炎に対応した一例

    日本歯科衛生学会第3回学術大会  2008年 

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  • 病棟での口腔ケア介入に基づき実施した血液検査が類天疱瘡の発見に繋がった一症例

    第1回日本口腔検査学会総会・学術大会  2008年 

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  • 歯周炎症がメタボリックシンドロームの病態に及ぼす影響を判定するための検査指標の確立を目指した基礎研究

    第1回日本口腔検査学会総会・学術大会  2008年 

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  • 不顕性脳血管疾患による嚥下遅延の病態に基づき対応した一症例

    第29回岡山歯学会総会・学術大会  2008年 

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  • 岡山大学病院糖尿病チームにおける歯科衛生士の役割

    第29回岡山歯学会総会・学術大会  2008年 

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  • 入院患者に対する口腔ケアの意義と実際

    第15回倉敷NST研究会  2008年 

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  • 低濃度LPSにより脂肪細胞・マクロファージ共培養系から産生される分子のサイトカインアレイ解析

    第51回春季日本歯周病学会学術大会  2008年 

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  • 口腔内感染症のコントロールによるがん治療への貢献―白血病治療における歯科介入の実例から―

    高度医療都市を創出する未来技術シンポジウム「先端テクノロジーの総合戦略:がんと感染症を考える」  2008年 

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  • IL12RB2転写制御領域の遺伝子多型が侵襲性歯周炎に対する疾患感受性の個体差に及ぼす影響

    日本病理学会  2008年 

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  • 易感染性宿主に対する口腔内ケアへの取り組み

    日本歯科医学会  2008年 

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  • 易感染性患者の敗血症の原因に根尖性歯周炎が関与することを示唆する1例

    第17回日本口腔感染症学会総会  2008年 

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  • Up-regulation of IL-6 production from adipocytes by LPS-stimulated macrophage

    85th International Association for Dental Research  2007年 

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  • 移植種(骨髄破壊的同種移植、骨髄非破壊的同種移植及び自家移植)と口腔粘膜障害の重症度との関連性に関する研究 ―予知性をもった口腔粘膜障害対策のために―

    第29回日本造血細胞移植学会総会  2007年 

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  • 原発性マクログロブリン血症を伴う慢性歯周炎症例

    第50回春季日本歯周病学会学術大会  2007年 

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  • Enhancement of cytokine production from LPS-stimulated monocyte under hyperglycemic condition

    85th International Association for Dental Research  2007年 

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  • 高血糖状態でLPS刺激を受けた単球におけるTNF-αおよびMCP-1の産生亢進にはJNKの活性化が深く関与する

    日本歯周病学会50周年記念大会  2007年 

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  • マクロファージはLPS刺激による脂肪細胞からのIL-6産生を強力に促進する

    第50回日本糖尿病学会年次学術集会  2007年 

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  • この5年間における邑久光明園歯科の変化と今後の課題

    第76回瀬戸内集談会  2007年 

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  • 高糖状態でLPS刺激を受けた単球はJNKを介して炎症性サイトカインを高産生する

    第50回日本糖尿病学会年次学術集会  2007年 

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  • 造血幹細胞移植患者の敗血症に口腔粘膜からの感染が関与する可能性の検討

    第7回Okayama Hematology Conference  2007年 

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  • マイクロサテライトを用いた相関解析による歯周炎感受性遺伝子同定 第19染色体全長の解析

    新潟医学会  2007年 

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  • Bacterial substitution on the oral mucosa during hematopoietic cell transplantation

    The 55th Annual Meeting of Japanese Association for Dental Research  2007年 

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  • 骨髄移植患者の口腔内細菌叢の変化

    日本歯科保存学会平成19年度秋季大会(第127回)  2007年 

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  • 造血幹細胞移植中に抗生剤多剤耐性の日和見感染症起因菌が歯肉に増殖した症例

    日本歯周病学会50周年記念大会  2007年 

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  • 高血糖状態によりLPS刺激単球で活性化されるシグナル伝達分子に関する研究

    日本歯科保存学会2006年春季学会(第124回)  2006年 

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  • 造血器腫瘍を中心とした血液疾患患者における歯周病の重症度とPorphyromonas gingivalisに対する血清IgG抗体価との関連性に関する研究

    第48回秋季日本歯周病学会学術大会  2006年 

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  • 高血糖状態でLPS刺激を受けた単球におけるJNK依存性のサイトカイン産生亢進

    第48回秋季日本歯周病学会学術大会  2006年 

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  • マクロファージはLPS刺激による脂肪細胞からのIL-6産生を強力に促進する

    第48回秋季日本歯周病学会学術大会  2006年 

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  • がん患者の口腔感染管理―造血幹細胞移植を例として―

    岡山大学病院院内感染対策講習会  2006年 

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  • マクロファージはLPS刺激による脂肪細胞からのIL-6産生を強力に促進する

    第54回日本口腔科学会 中国・四国地方部会  2006年 

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  • 急性骨髄性白血病患者の臍帯血移植期に歯肉に日和見菌の異常増殖を呈した症例―易感染期における口腔感染管理の重要性の考察―

    第54回日本口腔科学会 中国・四国地方部会  2006年 

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  • ハンセン病療養所における口腔健康管理および摂食嚥下障害の状況に関する調査

    第79回日本ハンセン病学会学術集会  2006年 

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  • Genome association study of periodontitis using chromosome 19 microsatellite polymorphisms

    84th International Association for Dental Research  2006年 

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  • 移植期中に口腔粘膜上から検出される細菌種に対する口腔内保湿ジェル(オーラルバランス®)の抗菌性の検討

    第28回日本造血細胞移植学会総会  2006年 

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  • マクロファージはLPS刺激による脂肪細胞からのIL-6産生を強力に促進する

    第21回日本糖尿病合併症学会  2006年 

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  • 造血幹細胞移植期中に口腔粘膜上から検出される細菌種に対する口腔内保湿ジェルの抗菌性の検討

    第20回日本顎頭蓋機能学会記念学術大会  2006年 

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  • 歯周感染が肝細胞のHMG-CoA還元酵素遺伝子発現に及ぼす影響

    第49回日本糖尿病学会年次学術集会  2006年 

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  • 歯周感染が肝細胞のコレステロール合成酵素遺伝子発現に及ぼす影響に関する研究

    日本歯科保存学会2005年春季学会(第122回)  2005年 

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  • 2型糖尿病患者におけるPorphyromonas gingivalis感染はLDL-コレステロールと相関する

    第47回春季日本歯周病学会学術大会  2005年 

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  • Porphyromonas gingivalis infection contributes to elevated LDL-cholesterol in diabetic subjects

    83th International Association for Dental Research  2005年 

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  • 口腔内の保湿に注目した口腔ケアへの取り組み-保湿ケア導入時期についての検討-

    平成16年度岡山大学医学部・歯学部附属病院看護部看護研究発表会  2005年 

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  • 口腔内の保湿に注目した口腔ケアへの取り組み―保湿ケア導入時期についての検討―

    第7回岡山Supportive Therapy研究会  2005年 

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  • 邑久光明園入所者の口腔健康管理および摂食嚥下障害に関する調査

    第74回瀬戸内集談会  2005年 

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  • マイクロサテライトを用いた相関解析による歯周病感受性遺伝子同定-第19染色体全長の解析-

    日本歯科保存学会2005年秋季学会(第123回)  2005年 

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受賞

  • 岡山歯学会奨励論文賞

    2009年  

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    受賞国:日本国

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  • 日本歯科保存学会奨励賞

    2005年  

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    受賞国:日本国

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  • 日本歯周病学会奨励賞

    2004年  

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    受賞国:日本国

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担当授業科目

  • 周術期口腔管理演習 (2021年度) 特別  - その他

  • 死生学・認知症 (2021年度) 第2学期  - その他

  • 高度医療支援・周術期口腔機能管理実習 (2021年度) 特別  - その他

  • 周術期口腔管理演習 (2020年度) 特別  - その他

  • 死生学・認知症 (2020年度) 第2学期  - その他

  • 高度医療支援・周術期口腔機能管理実習 (2020年度) 特別  - その他

▼全件表示