Faculty Profiles - KAWAZU Toshiyuki

MISC - KAWAZU Toshiyuki

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A case of multiple neurogenic tumors discovered with buccal mucosa schwannoma

久富美紀, 竹下洋平, 河合穂高, 岡田俊輔, 藤倉満美子, 吉田沙織, 河津俊幸, 長塚仁, 柳文修, 柳文修, 浅海淳一, 浅海淳一

日本口腔腫瘍学会総会・学術大会プログラム・抄録集 41st 2023

口腔顎顔面領域の臨床解剖と画像診断

竹下洋平, 河津俊幸, 久富美紀, 岡田俊輔, 藤倉満美子, 伊原木聰一郎, 岩永譲, 岩永譲, 影山幾男, 松下祐樹, TUBBS R. Shane, 浅海淳一, 浅海淳一, 浅海淳一

日本解剖学会総会・全国学術集会講演プログラム・抄録集 127th (CD-ROM) 2022

鼻咽腔に発生した若年性血管線維腫3例の比較検討

清水雄大, 村上純, 河津俊幸, 久富美紀, 藤田麻里子, 竹下洋平, 岡田俊輔, 難波友里, 柳文修, 浅海淳一, 浅海淳一, 浅海淳一

歯科放射線 59 2019

口腔扁平上皮癌術後の再発検出に対するTSE DWIの有用性

筑井徹, WANNAKAMON Panyarak, 河津俊幸, 山下泰生, 武村濃, 吉浦一紀, 吉浦一紀

歯科放射線 57 2017

下顎歯肉に認められた腺扁平上皮癌の1例

見立英史, 大部一成, 吉賀大午, 河津俊幸, 小林家吉, 川野真太郎, 中村誠司

日本口腔腫瘍学会総会・学術大会プログラム・抄録集 28th 2010

Sonographic diagnosis for Mikulicz disease

Mayumi Shimizu, Masafumi Moriyama, Kazutoshi Okamura, Toshiyuki Kawazu, Toru Chikui, Tazuko K. Goto, Yukiko Ohyama, Seiji Nakamura, Kazunori Yoshiura

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 108 ( 1 ) 105 - 113 2009.7

Language：English Publisher：MOSBY-ELSEVIER

Objective. The aim was to investigate the diagnostic imaging characteristics of Mikulicz disease (MD), especially sonographic ones, and to clarify the differences between them and those in Sjogren syndrome (SS), based on new criteria of MD.
Study design. The sonographic and sialographic images, as well as clinical, histopathologic, and serologic findings of 9 patients satisfying the new criteria of MD were analyzed and compared with those in SS.
Results. All swollen submandibular glands showed bilateral nodal hypoechoic areas with high vascularization on sonograms and a parenchymal defect on sialograms, whereas parotid glands showed normal or slight change on both images. Nodal areas in submandibular gland sonograms were unclear on computerized tomography and on magnetic resonance imaging, but showed accumulation on gallium scintigraphy.
Conclusion. Mikulicz disease showed a high rate of bilateral nodal change in submandibular glands, which was completely different from SS. For detection and follow-up of these changes, sonography may be the best imaging modality. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 105-113)

DOI： 10.1016/j.tripleo.2009.02.032

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Treatment of early tongue carcinoma with brachytherapy: Results over a 25-year period

Yusuke Urashima, Katsumasa Nakamura, Yoshiyuki Shioyama, Satoru Nomoto, Sair Ohga, Takashi Toba, Tadamasa Yoshitake, Toru Chikui, Toshiyuki Kawazu, Kenichi Jingu, Hiromi Terashima, Hiroshi Honda

ANTICANCER RESEARCH 27 ( 5B ) 3519 - 3523 2007.9

Language：English Publisher：INT INST ANTICANCER RESEARCH

Background: Brachytherapy for patients with early tongue cancer is an accepted method of treatment. Patients and Methods: The records of 409 patients with T1/2N0M0 tongue cancer treated with brachytherapy between 1978 and 2004 were reviewed. Results: The overall and disease-free 5-year survival rates were 82.3% and 64.6% for patients with T1 disease, and 72.2% and 56.0% for patients with T2 disease, respectively. The 5-year nodal metastasis-free survival rates for patients treated between 1978 and 1986, 1987 and 1996, and 1997 and 2004 were 64.8%, 74.8% and 81.3% for patients with T1 disease (p = 0.22), and 47.4%, 70.4% and 76.4% for patients with T2 disease (p = 0.0011), respectively. The 5-year local recurrence-free survival rates for patients treated between 1978 and 1986, 1987 and 1996, and 1997 and 2004 were 91.0%, 84.0% and 96.9% for patients with T1 disease (p = 0.31), and 87.6%, 83.3% and 85.8% for patients with T2 disease (p = 0. 90), respectively. Conclusion: The incidence rate of nodal metastasis in patients with early tongue cancer improved over the 25-year period studied, while the local recurrence-free survival rates remained stable.

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Is glossectomy necessary for late nodal metastases without clinical local recurrence after initial brachytherapy for N0 tongue cancer? A retrospective experience in 111 patients who received salvage therapy for cervical failure

Y Urashima, K Nakamura, N Kunitake, Y Shioyama, T Sasaki, S Ooga, Y Kuratomi, T Yamamoto, T Kawazu, T Chikui, K Jingu, H Terashima, H Honda

JAPANESE JOURNAL OF CLINICAL ONCOLOGY 36 ( 1 ) 3 - 6 2006.1

Language：English Publisher：OXFORD UNIV PRESS

Purpose: To assess the efficacy of neck dissection (ND) without glossectomy (GL) for late nodal metastases without local recurrence after brachytherapy for N0 tongue cancer.
Materials and methods: Among 396 patients with N0 tongue cancer treated with brachytherapy, a retrospective analysis was performed in 111 patients who were clinically diagnosed as having nodal metastases without local recurrence and whose neck lymph nodes turned out to be pathologically positive after salvage surgery. One hundred and five patients had undergone only ND (the ND group), six patients had undergone ND with GL (the ND+GL group).
Results: The 5 year disease-free and cause-specific survival rates after salvage therapy for the 111 patients included in this study were 58.1 and 61.9%, respectively. In the ND group, there were only nine patients who had local recurrence after ND. In addition, only six patients (5.7%) had a local recurrence within 2 years in the ND group. Sixty-three patients were free of disease after ND, 31 patients had regional or distant metastases without local recurrence and two patients had progressive disease at ND. In the ND+GL group, four patients were alive without disease and two died from regional or distant metastases. None of the patients in the ND+GL group were found to have malignant tissue in the pathological findings from the excised tongue.
Conclusion: GL should be avoided or suspended when the clinical evaluation had revealed cervical failure without apparent local recurrence in the mobile tongue cancer patients after initial brachytherapy.

DOI： 10.1093/jjco/hyi218

Intraoral sonographic features of tongue cancer after radical radiotherapy

Toru Chikui, Toshiyuki Kawazu, Katsumasa Nakamura, Yuusuke Urashima, Kenji Yuasa, Shigenobu Kanda

European Journal of Radiology 52 ( 3 ) 246 - 256 2004.12

Language：English Publishing type：Book review, literature introduction, etc.

Purpose: The purpose was to illustrate the sonographic changes of tongue cancer after radical radiotherapy. Materials and methods: In 24 patients with tongue cancer treated by interstitial brachytherapy (BRT) (uneventful recovery n=16, recurrence n=5, severe soft tissue complication n=3), follow-up examination were performed and both the margin and the vascular pattern were retrospectively assessed. We basically performed US examination at least once every 3 months after BRT within 1 year during follow-up period. Results: In the healing process, intraoral sonography shows an unclear margin immediately after brachytherapy and a transient increase of the vascularity lasted within 6 months after BRT, followed by a decrease in the vascularity. The large difference in echogenicity between the primary site and the surrounding tissue and the increased difference suggested the possibility of either radiation ulceration or recurrence. Conclusion: Intraoral sonography could depict the sequence changes of the tongue after BRT, and it was thus useful to confirm the clinical findings of either radiation ulcers or recurrence. © 2004 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ejrad.2004.01.012

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Quantitative analysis of radiological changes in alveolar bone around connected osseo-integrated dental implants and natural abutment teeth

TAKASHIMA Akihiro, YOSHIURA Kazunori, TOKUMORI Kenji, KAWAZU Toshiyuki, KANDA Shigenobu

19 ( 1 ) 28 - 37 2003.6

Analysis of different approaches to constructing perceptibility curves

YOSHIURA Kazunori, WELANDER Ulf, LI Gang, SHI Xie-Qi, MCDAVID William D., KAWAZU Toshiyuki, TATSUMI Masato, OKAMURA Kazutoshi, KANDA Shigenobu

Oral Radiol 19 ( 1 ) 38 - 48 2003.6

Perceptibility curves for the Digora system

K Yoshiura, U Welander, WD McDavid, G Li, XQ Shi, T Kawazu, M Tatsumi, T Matsuo, S Kanda

DENTOMAXILLOFACIAL RADIOLOGY 32 ( 3 ) 191 - 197 2003.5

Language：English Publisher：BRITISH INST RADIOLOGY

Objectives: To construct perceptibility curves (PCs) for given calibration settings in order to define psychophysical properties of the Digora storage phosphor system and to evaluate the effects of automatic exposure correction (AEC) on the PCs.
Methods: The Digora system was calibrated at two exposures, 80 muC kg(-1) (high calibration) and 40 RC kg(-1) (low calibration). Since the grey levels displayed in the radiographs are adjusted by AEC, dose-response functions at high calibration were obtained using AEC on and off modes. The dose-response function at low calibration was obtained with AEC off. The PC at each experimental setting was calculated using known physical parameters of the system and the performance of the average observer used in a previous study. In addition, PCs were also constructed using transmitted radiation flux behind the test object calculated from the attenuation coefficient in order to study observer and system performance. PCs obtained under these conditions were compared.
Results: The PC using calculated transmitted radiation flux behind the test object showed a wide plateau at the peak owing to AEC, while the PC obtained by a modified approach showed a higher but narrower peak. There were no differences between the two PCs using AEC on and off modes when the PCs were constructed using a modified approach. There were no differences between the two PCs obtained at high and low calibration settings or between the three PCs obtained with AEC on except for the position along the exposure axis.
Conclusions: Psychophysical properties of the Digora system may be determined if we employ registered exposures from a dose-response function with AEC off under a given calibration setting. Under these circumstances the shape and height of the PCs will be unchanged irrespective of the AEC mode.

DOI： 10.1259/dmfr/25806978

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Value of computed tomography findings in differentiating between intraosseous malignant tumors and osteomyelitis of the mandible affecting the masticator space Reviewed

Y Hariya, K Yuasa, E Nakayama, T Kawazu, K Okamura, S Kanda

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS 95 ( 4 ) 503 - 509 2003.4

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：MOSBY, INC

Objectives. We sought to evaluate the diagnostic efficacy of computed tomography (CT) images in the differentiation between intraosseous malignant tumors and osteomyelitis spreading into the masticator space.
Study design. A retrospective evaluation was carried out by using CT images from 12 patients with intraosseous malignant tumors and 9 patients with osteomyelitis involving the masticator space and accompanying mandibular bone destruction. The following CT observations are discussed: (1) bone destruction pattern subdivided into spotty, gross, or permeative; (2) cortical bone expansion; (3) diffuse osteosclerotic changes; (4) periosteal reaction; (5) masticator muscle involvement; (6) enlargement of the facial muscle; and (7) attenuation in the subcutaneous adipose tissue.
Results. The pattern of permeative bone destruction, cortical bone expansion, and the enlargement of both the masseter and medial pterygoid muscles were all observed in patients with malignant tumors. In contrast, diffuse sclerotic change and a periosteal reaction were significant observations in patients with osteomyelitis.
Conclusion. The efficacy of CT in establishing a differential diagnosis of malignant tumors or osteomyelitis is supported by this study.

DOI： 10.1067/moe.2003.134

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Application of Neural Networks to the Prediction of Lymph node Metastasis in Oral Cancer Reviewed

Toshiyuki Kawazu, Kazuyuki Araki, Kazunori Yoshiura, Eiji Nakayama, Shigenobu Kanda

Oral Radiology 19 ( 2 ) 137 - 142 2003.4

Diagnostic accuracy of CT in detecting the extent of tumor invasion into the surrounding soft tissue by squamous cell carcinoma of the mandibular gingiva

NAKAYAMA Eiji, YUASA Kenji, TABATA Osamu, KAWAZU Toshiyuki, CHIKUI Toru, KANDA Shigenobu, NAKAMURA Seiji, YOSHIKAWA Hiromasa, OOBU Kazunari, IKEBE Tetsuro, OHISHI Masamichi, SHIRASUNA Kanemitsu

Journal of Japanese Society of Oral Oncology 13 ( 4 ) 253 - 256 2001.12

Language：Japanese Publisher：Japanese Society of Oral Oncology

Objective: To clarify the diagnostic accuracy of CT in detecting the extent of tumor invasion into the surrounding soft tissues by squamous cell carcinoma of the mandibular gingiva.<BR>Method: Axial CT scans of 77 patients with carcinoma of the mandibular gingiva were evaluated by three Oral and maxillof acial radiologists for the tumor invasion into the surrounding soft tissues. All patients underwent excision of the tumor in Kyushu University Dental Hospital from 1992 to 1999, and the presence and the extent of tumor invasion were confirmed by the macroscopic or histopahological findings following surgery. The observers rated their level of confidence for the presence of tumor invasion into genioglossus muscle (GGM), mylohyoid muscle (MHM), intrinsic lingual muscles (ILM), internal pterygoid muscle (IPM), masseter muscle (MM), labiobuccal tissues (LBT), and platysma muscle (PM) on the following five-point scale : 1, negative ; 2, probably negative ; 3, unsure ; 4, probably positive; 5, positive. The mean ROC curve area (Az) of each observer for tumor invasion into each tissue was obtained, and used as the index of diagnostic accuracy.<BR>Results : The mean Az values for the detection of tumor invasion on CT was 0.86 for GGM and IPM, 0.82 for MHM, 0.80 for MM, 0.76 for ILM, 0.71 for LBT, and 0.65 for PM.<BR>Conclusion : We should carefully interpret the tumor invasion into ILM, LBT and PM on CT images referring to the various clinical information, including inspection or palpation.

DOI： 10.5843/jsot.13.Suppliment_253

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DIAGNOSIS OF CERVICAL LYMPH NODE METASTASIS USING POWER DOPPLER ULTRASONOGRAPHY

YUASA Kenji, CHIKUI Toru, KAWAZU Toshiyuki, NAKANO Toshiaki, KUNITAKE Naonobu, NAKAMURA Katsumasa, KANDA Shigenobu

27 ( 3 ) 727 - 731 2001.11

Effects of the automatic exposure compensation on the proximal caries diagnosis

YOSHIURA K, KAWAZU T, TATSUMI M, NAKAYAMA E, SHIMIZU M, GOTO TK, CHIKUI T, OKAMURA K, KANDA S

41 24 - 24 2001.9

Computer-Aided Diagnosis for cervical lymph node metastasis

KAWAZU T, ARAKI K, YUASA K, YOSHIURA K, KANDA S

41 45 - 45 2001.9

Newly Contrived Computer-aided Diagnostic System Using Fuzzy Inference Combined with Neural Network Algorism : An Attempt to the Sonographic Diagnosis

TANAKA T, KAWAZU T, KANDA S

41 79 - 79 2001.9

Conventional and predicted Perceptibility Curves for contrast-enhanced direct digital intraoral radiographs

K Yoshiura, U Welander, XQ Shi, G Li, T Kawazu, M Tatsumi, K Okamura, WD McDavid, S Kanda

DENTOMAXILLOFACIAL RADIOLOGY 30 ( 4 ) 219 - 225 2001.7

Language：English Publisher：NATURE PUBLISHING GROUP

Objectives: To construct Perceptibility Curves (PCs) for contrast-enhanced digital intraoral radiographs
Methods: Radiographs of a test object having holes of increasing depths were exposed using three digital systems, the CDR (Schick Technologies, Long Island, NY, USA), the Dixel (J Morita MFG, Kyoto, Japan) and the Sens-A-Ray (Regam Medical Systems, Sundsvall, Sweden). The radiographs were contrast-enhanced and PCs constructed in the conventional way using 10 observers. Predicted PCs were calculated and compared with observer data.
Results: The PCs showed that contrast enhancement is effective for the perception of small contrast details, especially in the low exposure range. Predicted PCs demonstrated excellent agreement with observer data.
Conclusions: Contrast enhancement should be advantageous in digital radiography. The effects of contrast enhancement on PCs may be predicted without previous knowledge of observer performance.

DOI： 10.1038/sj.dmfr.4600607

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